Instance ID12024
Regular ExpressionNPx[FY]
Motif InstanceNPLF
Bait Uniprot AccessionO00522
Bait Uniprot IdentifierKRIT1_HUMAN
Bait Gene NameKRIT1
Bait OrganismHomo sapiens (Human)
Sequence Position231-234
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureBeta turn
Experimental Method(s)X-ray crystallography; Mutational analysis; Peptide pulldown(GST tag)
Interaction ID22024
Interacting DomainFERM domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)25059659
CommentsThe FERM domain of human Sorting nexin-17 (SNX17), a member of the family of cytoplasmic sorting nexin adaptor proteins that regulate endosomal trafficking of cell surface proteins, binds directly to the second NPX(Y/F) motif in the Human Cytoplasmic Adaptor Protein Krev Interaction Trapped 1 (KRIT1)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)