Instance ID12031
Regular ExpressionQxx[ILM]xx[FHY][FHY]
Motif InstanceQEKITDTF
Bait Uniprot AccessionQ13569
Bait Uniprot IdentifierTDG_HUMAN
Bait Gene NameTDG
Bait OrganismHomo sapiens (Human)
Sequence Position95-102
Critical ResiduesP1; P4; P7; P8
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID22031
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)24962565
CommentsThe eight amino acid PCNA-binding motif in human Thymine-DNA glycosylase (TDG) that mediates its interaction with human Proliferating cell nuclear antigen (PCNA) and leads to targeting of TDG to the CRL4(Cdt2) E3 ubiquitin ligase complex

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)