Instance ID12055
Regular Expression[ILFV][ILFV]xxx[DE][DE]xx[DE]
Motif InstanceLLSTSEEQIE
Bait Uniprot AccessionP17181
Bait Uniprot IdentifierINAR1_HUMAN
Bait Gene NameIFNAR1
Bait OrganismHomo sapiens (Human)
Sequence Position491-500
Critical ResiduesP1; P2; P7; P10
Motif PTM(s)Unknown
Secondary StructureCoil
Experimental Method(s)X-ray crystallography; Site-directed mutagenesis; Pull down(GST tag)
Interaction ID22055
Interacting DomainSH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)24704786
CommentsThe peptide motif within the intracellular domain of human Interferon alpha receptor chain 1 (IFNAR1) that is necessary for its interaction with human Tyrosine kinase 2 (TYK2) as well as for TYK2 signaling

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)