Instance ID12056
Regular Expression[ILFVYM][ILFVYM]PPPPxxP
Motif InstanceYIPPPPAEP
Bait Uniprot AccessionQ8WXI2
Bait Uniprot IdentifierCNKR2_HUMAN
Bait Gene NameCNKSR2
Bait OrganismHomo sapiens (Human)
Sequence Position352-360
Critical ResiduesP3; P4; P5; P6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Co-IP
Interaction ID22056
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)24656827
CommentsHuman CNK homolog protein 2 (CNK2)/ Connector enhancer of KSR 2 (CNKSR2) interacts with the N-terminal region of human Rho GTPase-activating protein 39 (ARHGAP39) through a short proline-rich WW domain-binding motif and thereby modulates Rac cycling during spine morphogenesis in hippocampal neurons

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)