Instance ID12057
Regular Expression[IL]DLPxY
Motif InstanceLDLPPY
Bait Uniprot AccessionQ96PU5
Bait Uniprot IdentifierNED4L_HUMAN
Bait Gene NameNEDD4L
Bait OrganismHomo sapiens (Human)
Sequence Position846-851
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)NMR
Interaction ID22057
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)25295397
CommentsThe PY motif in the HECT domain of human E3 ubiquitin-protein ligase NEDD4L/KIAA0439 binds to the WW3 domain of human E3 ubiquitin-protein ligase NEDD4L/KIAA0439, suggesting a possible auto-ubquitination mechanism using two molecules, a partially unfolded one and a fully functional NEDD4L counterpart

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)