Instance ID12068
Regular Expressionxxx[ST]x[ACVILF]$
Motif InstanceEKSTKL
Bait Uniprot AccessionO43572
Bait Uniprot IdentifierAKA10_HUMAN
Bait Gene NameAKAP10
Bait OrganismHomo sapiens (Human)
Sequence Position657-662
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography; Peptide Array Screening
Interaction ID22068
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)25348485
CommentsThe six C-terminal residues of human Dual specificity A kinase-anchoring protein 2 (D-AKAP-2) or AKAP10 represent a C-terminal class 1 PDZ-binding motif that binds to the third and fourth PDZ domains of human Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)