Instance ID12071
Regular ExpressionNPx[FY]
Motif InstanceNPKY
Bait Uniprot AccessionP09055
Bait Uniprot IdentifierITB1_MOUSE
Bait Gene NameItgb1
Bait OrganismMus musculus (Mouse)
Sequence Position792-795
Critical ResiduesP4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID22071
Interacting DomainFERM domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)22561348
CommentsThe FERM domain of mouse Sorting nexin-17 (Snx17) binds to the NPX(Y/F) motif in the cytoplasmic domain of mouse Integrin beta-1 (Itgb1) to stabilize beta-1 integrins, resulting in their recycling to the cell surface where they can be reused

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)