Instance ID12073
Regular Expressionxxx[ST]x[ACVILF]$
Motif InstanceHTSTTL
Bait Uniprot AccessionP25025
Bait Uniprot IdentifierCXCR2_HUMAN
Bait Gene NameCXCR2
Bait OrganismHomo sapiens (Human)
Sequence Position355-360
Critical ResiduesP4; P5; P6
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID22073
Interacting DomainPDZ domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)23544174
CommentsThe C-terminal class 1 PDZ-binding motif in human C-X-C chemokine receptor type 2 (CXCR2) that binds to the PDZ domains of human Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)