Instance ID12074
Regular ExpressionPPxY
Motif InstancePPRY
Bait Uniprot AccessionQ8WWW0
Bait Uniprot IdentifierRASF5_HUMAN
Bait Gene NameRASSF5
Bait OrganismHomo sapiens (Human)
Sequence Position21-24
Critical ResiduesP4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID22074
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)23538446
CommentsThe PPXY motif of Human Ras association domain-containing protein 5 (RASSF5) that binds to the WW domains of Human E3 ubiquitin-protein ligase Itchy homolog (ITCH) thereby promoting the proteasomal degradation of RASSF5

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)