In Escherichia coli, interactions between the Chromosomal replication initiator protein DnaA, the beta subunit of DNA polymerase III (the sliding clamp protein), and the DnaA regulatory inactivator Hda, are required to convert the active ATP-bound form of DnaA to an inactive ADP-bound form through the accelerated hydrolysis of ATP and is mediated by the beta-binding hexapeptide motif in the amino terminus of Hda
