Instance ID12205
Regular Expression[ST]x[VL]$
Motif InstanceTRV
Bait Uniprot AccessionQ9Y5I7
Bait Uniprot IdentifierCLD16_HUMAN
Bait Gene NameCLDN16
Bait OrganismHomo sapiens (Human)
Sequence Position303-305
Critical ResiduesP1
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutational analysis; Pull down; Co-IP
Interaction ID22205
Interacting DomainPDZ domain
Disease Association(s)Familial hypomagnesemia with hypercalciuria and ne
Inhibitor(s)Unknown
Reference(s)14628289
CommentsC-terminal putative type 1 PDZ-binding motif in human renal tight junction protein Claudin-16 whose mutation abolishes binding to the human scaffolding protein ZO-1 resulting in its lysosomal mislocalization and is associated with childhood hypercalciuria


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)