Instance ID12210
Regular Expression[SV][CY]GH[LIF][LAST][GAIV]x
Motif InstanceSYGHLSIG
Bait Uniprot AccessionP08151
Bait Uniprot IdentifierGLI1_HUMAN
Bait Gene NameGLI1
Bait OrganismHomo sapiens (Human)
Sequence Position120-127
Critical ResiduesP3; P4; P5
Motif PTM(s)Unknown
Secondary StructureBeta strand
Experimental Method(s)Mutational analysis; X-ray crystallography; ITC; Pull down; Co-IP; Far Western assay; Microscale thermophoresis
Interaction ID22210
Interacting DomainSufu N-terminal binding domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)12426310, 24217340, 24311597
CommentsThe highly conserved ‘SYGHLS’ motif of human Zinc finger protein GLI1 that is critical for its association with human SUFU (Suppressor of fused homolog)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)