Instance ID12211
Regular Expression[SV][CY]GH[LIF][LAST][GAIV]x
Motif InstanceSYGHLSAS
Bait Uniprot AccessionP10071
Bait Uniprot IdentifierGLI3_HUMAN
Bait Gene NameGLI3
Bait OrganismHomo sapiens (Human)
Sequence Position333-340
Critical ResiduesP3; P4; P5
Motif PTM(s)Unknown
Secondary StructureBeta strand
Experimental Method(s)X-ray crystallography; Far Western assay
Interaction ID22211
Interacting DomainSufu N-terminal binding domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)12426310, 24311597
CommentsThe highly conserved ‘SYGHLS’ motif of human Transcriptional activator GLI3 that is critical for its association with human SUFU (Suppressor of fused homolog)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)