Instance ID12212
Regular Expression[SV][CY]GH[LIF][LAST][GAIV]x
Motif InstanceSYGHLSAG
Bait Uniprot AccessionQ0VGT2
Bait Uniprot IdentifierGLI2_MOUSE
Bait Gene NameGli2
Bait OrganismMus musculus (Mouse)
Sequence Position268-275
Critical ResiduesP3; P4; P5
Motif PTM(s)Unknown
Secondary StructureBeta strand
Experimental Method(s)Mutational analysis; X-ray crystallography; Co-IP
Interaction ID22212
Interacting DomainSufu N-terminal binding domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)24217340
CommentsThe highly conserved ‘SYGHLS’ motif of mouse Zinc finger protein Gli2 that is critical for its association with human SUFU (Suppressor of fused homolog)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)