Instance ID12215
Regular Expression[ILMV]xxx[ILMVF]xx[ILMVA][ILMVA]x[KR]Rxx[ILMVA]
Motif InstanceLVGALMHVMQKRSRA
Bait Uniprot AccessionP42768
Bait Uniprot IdentifierWASP_HUMAN
Bait Gene NameWAS
Bait OrganismHomo sapiens (Human)
Sequence Position466-480
Critical ResiduesP12
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)NMR; Spectrofluorometric affinity titration assay; GST-affinity assay
Interaction ID22215
Interacting DomainGTPase binding domain
Disease Association(s)X-linked severe congenital neutropenia
Inhibitor(s)Unknown
Reference(s)10724160, 11242115
CommentsThe autoinhibitory intramolecular interaction between the GTPase-binding domain and the carboxy-terminal region of human Wiskott-Aldrich syndrome protein that occlude residues of the C terminus which regulate the Arp2/3 actin-nucleating complex

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)