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Total : 129 Records
Record No : 1 |
| Instance ID | 10001 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RRWSAP | | Bait Uniprot Accession | P54253 | | Bait Uniprot Identifier | ATX1_HUMAN | | Bait Gene Name | ATXN1 | | Sequence Position | 772-777 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Co-IP; Mutation analysis; Y2H | | Interaction ID | 20001 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Spinocerebellar ataxia type 1 | | Inhibitor(s) | Unknown | | Reference(s) | 20037628, 12757707 | | Comments | 14-3-3 binding motif of Ataxin-1 (Atx1), a member of the polyglutamine (polyQ) expanded protein family, responsible for spinocerebellar ataxia type 1 |
Record No : 2 |
| Instance ID | 10002 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RRWSAP | | Bait Uniprot Accession | P54253 | | Bait Uniprot Identifier | ATX1_HUMAN | | Bait Gene Name | ATXN1 | | Sequence Position | 772-777 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Co-IP; Mutation analysis; Y2H | | Interaction ID | 20002 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Spinocerebellar ataxia type 1 | | Inhibitor(s) | Unknown | | Reference(s) | 20037628, 12757707 | | Comments | 14-3-3 binding motif of Ataxin-1 (Atx1), a member of the polyglutamine (polyQ) expanded protein family, responsible for spinocerebellar ataxia type 1 |
Record No : 3 |
| Instance ID | 10003 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RRWSAP | | Bait Uniprot Accession | P54253 | | Bait Uniprot Identifier | ATX1_HUMAN | | Bait Gene Name | ATXN1 | | Sequence Position | 772-777 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Co-IP; Mutation analysis; Y2H | | Interaction ID | 20003 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Spinocerebellar ataxia type 1 | | Inhibitor(s) | Unknown | | Reference(s) | 20037628, 12757707 | | Comments | 14-3-3 binding motif of Ataxin-1 (Atx1), a member of the polyglutamine (polyQ) expanded protein family, responsible for spinocerebellar ataxia type 1 |
Record No : 4 |
| Instance ID | 10004 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RRWSAP | | Bait Uniprot Accession | P54253 | | Bait Uniprot Identifier | ATX1_HUMAN | | Bait Gene Name | ATXN1 | | Sequence Position | 772-777 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Co-IP; Mutation analysis; Y2H | | Interaction ID | 20004 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Spinocerebellar ataxia type 1 | | Inhibitor(s) | Unknown | | Reference(s) | 20037628, 12757707 | | Comments | 14-3-3 binding motif of Ataxin-1 (Atx1), a member of the polyglutamine (polyQ) expanded protein family, responsible for spinocerebellar ataxia type 1 |
Record No : 5 |
| Instance ID | 10055 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSWQ | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Sequence Position | 831-836 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Western blot; Alanine scanning | | Interaction ID | 20055 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (831-836) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein beta |
Record No : 6 |
| Instance ID | 10056 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSWQ | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Sequence Position | 831-836 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Western blot; Alanine scanning | | Interaction ID | 20056 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (831-836) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein gamma |
Record No : 7 |
| Instance ID | 10057 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSWQ | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Sequence Position | 831-836 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Western blot; Alanine scanning | | Interaction ID | 20057 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (831-836) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein epsilon |
Record No : 8 |
| Instance ID | 10058 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSWQ | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Sequence Position | 831-836 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Western blot; Alanine scanning | | Interaction ID | 20058 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (831-836) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein zeta |
Record No : 9 |
| Instance ID | 10059 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSWQ | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Sequence Position | 831-836 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Western blot; Alanine scanning | | Interaction ID | 20059 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (831-836) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein eta |
Record No : 10 |
| Instance ID | 10060 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSWQ | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Sequence Position | 831-836 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Western blot; Alanine scanning | | Interaction ID | 20060 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (831-836) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein tau |
Record No : 11 |
| Instance ID | 10063 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSTE | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Sequence Position | 854-859 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Pull down; Mutation analysis | | Interaction ID | 20063 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (854-859) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein beta |
Record No : 12 |
| Instance ID | 10064 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSTE | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Sequence Position | 854-859 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Pull down; Mutation analysis | | Interaction ID | 20064 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (854-859) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein gamma |
Record No : 13 |
| Instance ID | 10065 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSTE | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Sequence Position | 854-859 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Pull down; Mutation analysis | | Interaction ID | 20065 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (854-859) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein epsilon |
Record No : 14 |
| Instance ID | 10066 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSTE | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Sequence Position | 854-859 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Pull down; Mutation analysis | | Interaction ID | 20066 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (854-859) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein zeta |
Record No : 15 |
| Instance ID | 10067 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSTE | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Sequence Position | 854-859 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Pull down; Mutation analysis | | Interaction ID | 20067 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (854-859) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein eta |
Record No : 16 |
| Instance ID | 10068 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSTE | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Sequence Position | 854-859 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Pull down; Mutation analysis | | Interaction ID | 20068 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16868027 | | Comments | Phosphoserine consensus motif (854-859) for 14-3-3 binding in human Metalloproteinase-disintegrin ADAM22 that binds to 14-3-3 protein tau |
Record No : 17 |
| Instance ID | 10127 | | Regular Expression | FxxF$ | | Motif Instance | FEFF | | Bait Uniprot Accession | Q5I6E9 | | Bait Uniprot Identifier | Q5I6E9_SOLLC | | Bait Gene Name | Adi3 | | Sequence Position | 697-700 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Co-IP; Mutation analysis | | Interaction ID | 20127 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Bacterial speck disease in tomato | | Inhibitor(s) | Unknown | | Reference(s) | 16362044 | | Comments | "The C-terminal hydrophobic motif in tomato AvrPto-dependent Pto-interacting protein 3 (Adi3), which acts as a ""docking site"" for recruitment of tomato Pdk1, Adi3 thus negatively regulating cell death via Pdk1 phosphorylation" |
Record No : 18 |
| Instance ID | 10132 | | Regular Expression | FxDxF | | Motif Instance | FEDNF | | Bait Uniprot Accession | P49418 | | Bait Uniprot Identifier | AMPH_HUMAN | | Bait Gene Name | AMPH | | Sequence Position | 324-328 | | Critical Residues | P1; P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20132 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12057195 | | Comments | The minimal region of human Amphiphysin I required to associate with the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 19 |
| Instance ID | 10133 | | Regular Expression | FxDxF | | Motif Instance | FEDNF | | Bait Uniprot Accession | O08838 | | Bait Uniprot Identifier | AMPH_RAT | | Bait Gene Name | Amph | | Sequence Position | 324-328 | | Critical Residues | P1; P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; X-ray crystallography; Pull down; Mutation analysis | | Interaction ID | 20133 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17986641 | | Comments | The FXDXF motif in rat Amphiphysin I that is the main determinant for the high affinity interaction with the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 20 |
| Instance ID | 10141 | | Regular Expression | DP[FW] | | Motif Instance | DPF | | Bait Uniprot Accession | O08838 | | Bait Uniprot Identifier | AMPH_RAT | | Bait Gene Name | Amph | | Sequence Position | 357-359 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis; Competition binding; Classical fluorescence spectroscopy; Far Western blotting | | Interaction ID | 20141 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10380931 | | Comments | The DPF/W motif (357-359) of rat Amphiphysin I that binds the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 21 |
| Instance ID | 10170 | | Regular Expression | xKENx | | Motif Instance | QKENS | | Bait Uniprot Accession | Q96GD4 | | Bait Uniprot Identifier | AURKB_HUMAN | | Bait Gene Name | AURKB | | Sequence Position | 3-7 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20170 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17726374, 15923616 | | Comments | KEN-box motif in human Aurora kinase B, a regulator of chromosome segregation and cytokinesis, for binding to the degradation-targeting protein Cdh1 |
Record No : 22 |
| Instance ID | 10172 | | Regular Expression | xKENx | | Motif Instance | VKENL | | Bait Uniprot Accession | Q08981 | | Bait Uniprot Identifier | ACM1_YEAST | | Bait Gene Name | ACM1 | | Sequence Position | 97-101 | | Critical Residues | P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20172 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18596038 | | Comments | KEN box motif in budding yeast Acm1 protein that is required for high affinity interaction with the substrate receptor site on the WD40 domain of Cdh1 that may serve both to promote APC inhibition and protect Acm1 from destruction |
Record No : 23 |
| Instance ID | 10179 | | Regular Expression | x[ILM]R$ | | Motif Instance | SIR | | Bait Uniprot Accession | Q9UM13 | | Bait Uniprot Identifier | APC10_HUMAN | | Bait Gene Name | ANAPC10 | | Sequence Position | 183-185 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation disrupting interaction; Peptide binding to perpetrator; Co-IP; Mutation analysis; Pull down | | Interaction ID | 20179 | | Interacting Domain | Tetratricopeptide repeats | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11524682 | | Comments | The C-terminus of APC10 that binds to the tetratrico peptide repeats of CDC27/APC3 |
Record No : 24 |
| Instance ID | 10192 | | Regular Expression | DR[YFH][ILFVM][PA]xx | | Motif Instance | DRFIPKS | | Bait Uniprot Accession | P50082 | | Bait Uniprot Identifier | AMA1_YEAST | | Bait Gene Name | AMA1 | | Sequence Position | 29-35 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20192 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21118994 | | Comments | Motif present in yeast Meiosis-specific APC/C activator protein AMA1 for mediating its interaction with yeast CDC20 |
Record No : 25 |
| Instance ID | 10196 | | Regular Expression | [DE][DES][DEGAS]F[SGAD][DEAP][LVIMFD] | | Motif Instance | DDEFGEF | | Bait Uniprot Accession | Q6ULP2 | | Bait Uniprot Identifier | AFTIN_HUMAN | | Bait Gene Name | AFTPH | | Sequence Position | 25-31 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 20196 | | Interacting Domain | Gamma adaptin ear (GAE) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14665628 | | Comments | Putative Gamma-adaptin ear interaction motif (25-31) in human Aftiphilin that interacts with gamma-ear domain of Golgi-localized, gamma ear-containing, ARF-binding protein 1 (GGA1) |
Record No : 26 |
| Instance ID | 10198 | | Regular Expression | [DE][DES][DEGAS]F[SGAD][DEAP][LVIMFD] | | Motif Instance | EDDFGDF | | Bait Uniprot Accession | Q6ULP2 | | Bait Uniprot Identifier | AFTIN_HUMAN | | Bait Gene Name | AFTPH | | Sequence Position | 429-435 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 20198 | | Interacting Domain | Gamma adaptin ear (GAE) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14665628 | | Comments | Putative Gamma-adaptin ear interaction motif (429-435) in human Aftiphilin that interacts with gamma-ear domain of Golgi-localized, gamma ear-containing, ARF-binding protein 1 (GGA1) |
Record No : 27 |
| Instance ID | 10213 | | Regular Expression | x(S)xxF | | Motif Instance | CSPQF | | Bait Uniprot Accession | Q8WXE1 | | Bait Uniprot Identifier | ATRIP_HUMAN | | Bait Gene Name | ATRIP | | Sequence Position | 238-242 | | Critical Residues | P2; P3; P4; P5 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; X-ray crystallography; Co-IP; Pull down | | Interaction ID | 20213 | | Interacting Domain | BRCT domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17616665, 24073851 | | Comments | Phosphorylated serine (pS) sequence in human ATR-interacting protein (ATRIP) that mediates a direct physical interaction with the carboxyl-terminal domain (BRCT) of the Breast Cancer Gene 1 (BRCA1) protein and checkpoint function |
Record No : 28 |
| Instance ID | 10216 | | Regular Expression | x(S)xxF | | Motif Instance | QSPTF | | Bait Uniprot Accession | Q13085 | | Bait Uniprot Identifier | ACACA_HUMAN | | Bait Gene Name | ACACA | | Sequence Position | 1262-1266 | | Critical Residues | P2; P5 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Co-IP; Pull down | | Interaction ID | 20216 | | Interacting Domain | BRCT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18452305, 16698035 | | Comments | Phosphorylated serine (pS) sequence in human Acetyl-CoA carboxylase 1 (ACACA) that mediates specific interaction with the carboxyl-terminal domain (BRCT) of the Breast Cancer Gene 1 (BRCA1) protein |
Record No : 29 |
| Instance ID | 10222 | | Regular Expression | ((SP)|([ED]x{0,1}))[IV]W[IVL]xR | | Motif Instance | EPIWVMR | | Bait Uniprot Accession | Q02410 | | Bait Uniprot Identifier | APBA1_HUMAN | | Bait Gene Name | APBA1 | | Sequence Position | 376-382 | | Critical Residues | P3; P4; P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20222 | | Interacting Domain | CaMK domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9952408, 21763699 | | Comments | The CASK-CaMK-binding motif in human Adapter protein X11alpha (APBA1) that mediates specific binding to the CaMK domain of the CASK protein |
Record No : 30 |
| Instance ID | 10223 | | Regular Expression | ((SP)|([ED]x{0,1}))[IV]W[IVL]xR | | Motif Instance | EPIWVMR | | Bait Uniprot Accession | O35430 | | Bait Uniprot Identifier | APBA1_RAT | | Bait Gene Name | Apba1 | | Sequence Position | 378-384 | | Critical Residues | P3; P4; P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20223 | | Interacting Domain | CaMK domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9753324, 12040031 | | Comments | The CASK-CaMK-binding motif in rat Adapter protein X11alpha (Apba1/Mint1) that mediates specific binding to the CaMK domain of the rat Peripheral plasma membrane protein CASK |
Record No : 31 |
| Instance ID | 10224 | | Regular Expression | ((SP)|([ED]x{0,1}))[IV]W[IVL]xR | | Motif Instance | EPIWVMR | | Bait Uniprot Accession | B2RUJ5 | | Bait Uniprot Identifier | APBA1_MOUSE | | Bait Gene Name | Apba1 | | Sequence Position | 381-387 | | Critical Residues | P3; P4; P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20224 | | Interacting Domain | CaMK domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9952408 | | Comments | The CASK-CaMK-binding motif in mouse Adapter protein X11alpha (Apba1/Mint1) that mediates specific binding to the CaMK domain of the mouse Peripheral plasma membrane protein CASK |
Record No : 32 |
| Instance ID | 10232 | | Regular Expression | L[IVLMF]x[IVLMF][DE] | | Motif Instance | LLDLD | | Bait Uniprot Accession | P49418 | | Bait Uniprot Identifier | AMPH_HUMAN | | Bait Gene Name | AMPH | | Sequence Position | 351-355 | | Critical Residues | P3; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 20232 | | Interacting Domain | Clathrin propeller repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10748223 | | Comments | Clathrin box motif in human Amphiphysin (AMPH) that is sufficient for binding to the amino terminal beta propeller structure of Clathrin heavy chain |
Record No : 33 |
| Instance ID | 10233 | | Regular Expression | L[IVLMF]x[IVLMF][DE] | | Motif Instance | LLDLE | | Bait Uniprot Accession | Q13367 | | Bait Uniprot Identifier | AP3B2_HUMAN | | Bait Gene Name | AP3B2 | | Sequence Position | 808-812 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Western blot; Confocal microscopy; Classical fluorescence spectroscopy; Pull down | | Interaction ID | 20233 | | Interacting Domain | Clathrin propeller repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9545220 | | Comments | Clathrin box motif in human AP-3 complex subunit beta-2 that is sufficient for binding to the amino terminal beta propeller structure of Clathrin heavy chain |
Record No : 34 |
| Instance ID | 10234 | | Regular Expression | L[IVLMF]x[IVLMF][DE] | | Motif Instance | LIEFD | | Bait Uniprot Accession | Q91YI4 | | Bait Uniprot Identifier | ARRB2_MOUSE | | Bait Gene Name | Arrb2 | | Sequence Position | 374-378 | | Critical Residues | P1; P2; P3; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Alanine scanning; Mutation analysis; Pull down | | Interaction ID | 20234 | | Interacting Domain | Clathrin propeller repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9169476 | | Comments | Clathrin box motif in the mouse Arrestin beta-2 that interact with the N-terminal beta-propeller structure of Clathrin heavy chain |
Record No : 35 |
| Instance ID | 10235 | | Regular Expression | L[IVLMF]x[IVLMF][DE] | | Motif Instance | LLDLD | | Bait Uniprot Accession | O00203 | | Bait Uniprot Identifier | AP3B1_HUMAN | | Bait Gene Name | AP3B1 | | Sequence Position | 818-822 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20235 | | Interacting Domain | Clathrin propeller repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10655490 | | Comments | Clathrin box motif in human AP-3 complex subunit beta-1 that is sufficient for binding to the amino terminal beta propeller structure of Clathrin heavy chain |
Record No : 36 |
| Instance ID | 10236 | | Regular Expression | L[IVLMF]x[IVLMF][DE] | | Motif Instance | LIEFE | | Bait Uniprot Accession | P32120 | | Bait Uniprot Identifier | ARRB2_BOVIN | | Bait Gene Name | ARRB2 | | Sequence Position | 384-388 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Peptide binding to perpetrator; X-ray crystallography | | Interaction ID | 20236 | | Interacting Domain | Clathrin propeller repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10655490 | | Comments | Clathrin box motif in the bovine Arrestin beta-2 that interact with the N-terminal beta-propeller structure of Clathrin heavy chain |
Record No : 37 |
| Instance ID | 10239 | | Regular Expression | x[NP]W[DES]xW | | Motif Instance | LPWDLW | | Bait Uniprot Accession | P49418 | | Bait Uniprot Identifier | AMPH_HUMAN | | Bait Gene Name | AMPH | | Sequence Position | 380-385 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Western blot; Mutation analysis; X-ray crystallography; Classical fluorescence spectroscopy | | Interaction ID | 20239 | | Interacting Domain | Clathrin propeller repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11382783, 14981508, 10748223 | | Comments | "Variant clathrin box motif (W box) in human Amphiphysin that are found in tandem arrangement with a ""classical"" clathrin box and cooperate to effect optimal clathrin binding and the formation of sedimentable assemblies" |
Record No : 38 |
| Instance ID | 10291 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | KKLF | | Bait Uniprot Accession | Q9WTQ5 | | Bait Uniprot Identifier | AKA12_MOUSE | | Bait Gene Name | Akap12 | | Sequence Position | 501-504 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20291 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10982843 | | Comments | SSeCKS, a major protein kinase C substrate with tumor suppressor activity, regulates G(1)-->S progression by controlling the expression and cellular compartmentalization of cyclin D through a physical association with cyclin D via its RxL motif |
Record No : 39 |
| Instance ID | 10317 | | Regular Expression | xNPFx | | Motif Instance | TNPFQ | | Bait Uniprot Accession | P52594 | | Bait Uniprot Identifier | AGFG1_HUMAN | | Bait Gene Name | AGFG1 | | Sequence Position | 448-452 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 20317 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9446614 | | Comments | Asn-Pro-Phe motif in human Arf-GAP domain and FG repeat-containing protein 1 that is responsible for the interaction with Eps15 homology (EH) domain of Eps15-related protein (Eps15R or EPS15L1) |
Record No : 40 |
| Instance ID | 10318 | | Regular Expression | xNPFx | | Motif Instance | TNPFL | | Bait Uniprot Accession | P52594 | | Bait Uniprot Identifier | AGFG1_HUMAN | | Bait Gene Name | AGFG1 | | Sequence Position | 558-562 | | Critical Residues | P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Classical fluorescence spectroscopy; Display technology; Pull down; SPR; NMR | | Interaction ID | 20318 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9303539, 9446614, 9721102, 11062555 | | Comments | Asn-Pro-Phe motif (558-562) in human Arf-GAP domain and FG repeat-containing protein 1 that is responsible for the interaction with Eps15 homology (EH) domain of Epidermal growth factor receptor substrate 15 (EPS15) |
Record No : 41 |
| Instance ID | 10319 | | Regular Expression | xNPFx | | Motif Instance | TNPFQ | | Bait Uniprot Accession | O95081 | | Bait Uniprot Identifier | AGFG2_HUMAN | | Bait Gene Name | AGFG2 | | Sequence Position | 380-384 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20319 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9303539 | | Comments | Asn-Pro-Phe motif (380-384) in human Arf-GAP domain and FG repeat-containing protein 2 that is responsible for the interaction with Eps15 homology (EH) domain of Epidermal growth factor receptor substrate 15 (EPS15) |
Record No : 42 |
| Instance ID | 10323 | | Regular Expression | xNPFx | | Motif Instance | SNPFM | | Bait Uniprot Accession | P52594 | | Bait Uniprot Identifier | AGFG1_HUMAN | | Bait Gene Name | AGFG1 | | Sequence Position | 539-543 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down | | Interaction ID | 20323 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9303539, 9446614 | | Comments | Asn-Pro-Phe motif (557-561) in human Arf-GAP domain and FG repeat-containing protein 1 that is responsible for the interaction with Eps15 homology (EH) domain of Epidermal growth factor receptor substrate 15 (EPS15) |
Record No : 43 |
| Instance ID | 10324 | | Regular Expression | xNPFx | | Motif Instance | TNPFL | | Bait Uniprot Accession | Q8K2K6 | | Bait Uniprot Identifier | AGFG1_MOUSE | | Bait Gene Name | Agfg1 | | Sequence Position | 557-561 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR | | Interaction ID | 20324 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10471276 | | Comments | EH domain-dependent interaction between mouse Eps15 and NPF-containing peptide derived from RAB, the cellular cofactor of the HIV Rev protein (Agfg1) |
Record No : 44 |
| Instance ID | 10326 | | Regular Expression | xNPFx | | Motif Instance | TNPFM | | Bait Uniprot Accession | O95081 | | Bait Uniprot Identifier | AGFG2_HUMAN | | Bait Gene Name | AGFG2 | | Sequence Position | 458-462 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20326 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9303539 | | Comments | Asn-Pro-Phe motif (458-462) in human Arf-GAP domain and FG repeat-containing protein 2 that is responsible for the interaction with Eps15 homology (EH) domain of Epidermal growth factor receptor substrate 15 (EPS15) |
Record No : 45 |
| Instance ID | 10327 | | Regular Expression | xNPFx | | Motif Instance | TNPFV | | Bait Uniprot Accession | P52594 | | Bait Uniprot Identifier | AGFG1_HUMAN | | Bait Gene Name | AGFG1 | | Sequence Position | 433-437 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Co-IP | | Interaction ID | 20327 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9303539, 9446614 | | Comments | Asn-Pro-Phe motif (433-437) in human Arf-GAP domain and FG repeat-containing protein 1 that is responsible for the interaction with Eps15 homology (EH) domain of Epidermal growth factor receptor substrate 15 (EPS15) |
Record No : 46 |
| Instance ID | 10328 | | Regular Expression | xNPFx | | Motif Instance | TNPFT | | Bait Uniprot Accession | O95081 | | Bait Uniprot Identifier | AGFG2_HUMAN | | Bait Gene Name | AGFG2 | | Sequence Position | 365-369 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20328 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9303539 | | Comments | Asn-Pro-Phe motif (365-369) in human Arf-GAP domain and FG repeat-containing protein 2 that is responsible for the interaction with Eps15 homology (EH) domain of Epidermal growth factor receptor substrate 15 (EPS15) |
Record No : 47 |
| Instance ID | 10330 | | Regular Expression | xNPFx | | Motif Instance | TNPFL | | Bait Uniprot Accession | O95081 | | Bait Uniprot Identifier | AGFG2_HUMAN | | Bait Gene Name | AGFG2 | | Sequence Position | 477-481 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20330 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9303539 | | Comments | Asn-Pro-Phe motif (477-481) in human Arf-GAP domain and FG repeat-containing protein 2 that is responsible for the interaction with Eps15 homology (EH) domain of Epidermal growth factor receptor substrate 15 (EPS15) |
Record No : 48 |
| Instance ID | 10368 | | Regular Expression | xNPFx | | Motif Instance | ANPFQ | | Bait Uniprot Accession | P34552 | | Bait Uniprot Identifier | ALX1_CAEEL | | Bait Gene Name | alx-1 | | Sequence Position | 878-882 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Pull down; Mutation analysis | | Interaction ID | 20368 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17997305 | | Comments | The interaction of ALX-1 with RME-1 in C. elegans, mediated by RME-1/YPSL and ALX-1/NPF motifs |
Record No : 49 |
| Instance ID | 10430 | | Regular Expression | ([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P) | | Motif Instance | FPPIP | | Bait Uniprot Accession | P33379 | | Bait Uniprot Identifier | ACTA_LISMO | | Bait Gene Name | actA | | Sequence Position | 380-384 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Solid phase binding assay; Blot overlay assay | | Interaction ID | 20430 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312002 | | Comments | Proline-rich motif (380-384) present in ActA of Listeria monocytogenes that is required for its interaction with VASP |
Record No : 50 |
| Instance ID | 10431 | | Regular Expression | ([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P) | | Motif Instance | FPPIP | | Bait Uniprot Accession | P33379 | | Bait Uniprot Identifier | ACTA_LISMO | | Bait Gene Name | actA | | Sequence Position | 380-384 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Solid phase binding assay | | Interaction ID | 20431 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312002 | | Comments | Proline-rich motif (380-384) present in ActA of Listeria monocytogenes that is required for its interaction with ENAH |
Record No : 51 |
| Instance ID | 10432 | | Regular Expression | ([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P) | | Motif Instance | FPPPP | | Bait Uniprot Accession | Q12955 | | Bait Uniprot Identifier | ANK3_HUMAN | | Bait Gene Name | ANK3 | | Sequence Position | 3254-3258 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding to perpetrator | | Interaction ID | 20432 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312002 | | Comments | Proline-rich motif present in human Ankyrin-G that is required for its interaction with VASP |
Record No : 52 |
| Instance ID | 10433 | | Regular Expression | ([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P) | | Motif Instance | FPPPP | | Bait Uniprot Accession | Q12955 | | Bait Uniprot Identifier | ANK3_HUMAN | | Bait Gene Name | ANK3 | | Sequence Position | 3254-3258 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding to perpetrator | | Interaction ID | 20433 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312002 | | Comments | Proline-rich motif present in human Ankyrin-G that is required for its interaction with ENAH |
Record No : 53 |
| Instance ID | 10434 | | Regular Expression | ([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P) | | Motif Instance | FPPIP | | Bait Uniprot Accession | P33379 | | Bait Uniprot Identifier | ACTA_LISMO | | Bait Gene Name | actA | | Sequence Position | 335-339 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Solid phase binding assay; Blot overlay assay | | Interaction ID | 20434 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312002 | | Comments | Proline-rich motif (335-339) present in ActA of Listeria monocytogenes that is required for its interaction with VASP |
Record No : 54 |
| Instance ID | 10435 | | Regular Expression | ([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P) | | Motif Instance | FPPIP | | Bait Uniprot Accession | P33379 | | Bait Uniprot Identifier | ACTA_LISMO | | Bait Gene Name | actA | | Sequence Position | 335-339 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Solid phase binding assay | | Interaction ID | 20435 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312002 | | Comments | Proline-rich motif (335-339) present in ActA of Listeria monocytogenes that is required for its interaction with ENAH |
Record No : 55 |
| Instance ID | 10436 | | Regular Expression | ([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P) | | Motif Instance | FPPIP | | Bait Uniprot Accession | P33379 | | Bait Uniprot Identifier | ACTA_LISMO | | Bait Gene Name | actA | | Sequence Position | 265-269 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Solid phase binding assay; Blot overlay assay | | Interaction ID | 20436 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312002 | | Comments | Proline-rich motif (265-269) present in ActA of Listeria monocytogenes that is required for its interaction with VASP |
Record No : 56 |
| Instance ID | 10437 | | Regular Expression | ([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P) | | Motif Instance | FPPIP | | Bait Uniprot Accession | P33379 | | Bait Uniprot Identifier | ACTA_LISMO | | Bait Gene Name | actA | | Sequence Position | 265-269 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Solid phase binding assay | | Interaction ID | 20437 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312002 | | Comments | Proline-rich motif (265-269) present in ActA of Listeria monocytogenes that is required for its interaction with ENAH |
Record No : 57 |
| Instance ID | 10438 | | Regular Expression | ([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P) | | Motif Instance | FPPIP | | Bait Uniprot Accession | P33379 | | Bait Uniprot Identifier | ACTA_LISMO | | Bait Gene Name | actA | | Sequence Position | 300-304 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Solid phase binding assay; Blot overlay assay | | Interaction ID | 20438 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312002 | | Comments | Proline-rich motif (300-304) present in ActA of Listeria monocytogenes that is required for its interaction with VASP |
Record No : 58 |
| Instance ID | 10439 | | Regular Expression | ([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P) | | Motif Instance | FPPIP | | Bait Uniprot Accession | P33379 | | Bait Uniprot Identifier | ACTA_LISMO | | Bait Gene Name | actA | | Sequence Position | 300-304 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Solid phase binding assay | | Interaction ID | 20439 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312002 | | Comments | Proline-rich motif (300-304) present in ActA of Listeria monocytogenes that is required for its interaction with ENAH |
Record No : 59 |
| Instance ID | 10467 | | Regular Expression | P[MVLIRWY]V[MVLIAS][LM] | | Motif Instance | PLVVL | | Bait Uniprot Accession | Q9VI63 | | Bait Uniprot Identifier | Q9VI63_DROME | | Bait Gene Name | Alh | | Sequence Position | 1051-1055 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag) | | Interaction ID | 20467 | | Interacting Domain | Chromo shadow domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11266362 | | Comments | The PxVxL HP1-binding motif found in the Drosophila homolog of the human AF10, dAF10, that interacts with a chomoshadow domain dimer of the heterochromatin protein 1 (HP1) |
Record No : 60 |
| Instance ID | 10490 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | AVVLGLVQSLNRQRQKQLL | | Bait Uniprot Accession | P40146 | | Bait Uniprot Identifier | ADCY8_RAT | | Bait Gene Name | Adcy8 | | Sequence Position | 1191-1209 | | Critical Residues | P7; P8; P12; P14 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 20490 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19305019 | | Comments | The Calmodulin binding IQ motif of the rat Ca(2+)/calmodulin-activated Adenylate cyclase type 8 (Adcy8) that binds to the apo C-domain of rat Calmodulin (CaM) |
Record No : 61 |
| Instance ID | 10589 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | STLNPNAKEFNPR | | Bait Uniprot Accession | Q99700 | | Bait Uniprot Identifier | ATX2_HUMAN | | Bait Gene Name | ATXN2 | | Sequence Position | 912-924 | | Critical Residues | P3; P5; P7; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | ITC; NMR; SPR; X-ray crystallography | | Interaction ID | 20589 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16554297, 20181956 | | Comments | The PABP-interacting motif 2 (PAM2) in human Ataxin-2 (ATXN2) that mediates binding to the MLLE domain of Polyadenylate-binding protein 1 (PABP1/PABPC1/PABPC2) |
Record No : 62 |
| Instance ID | 10590 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | HVLNPSAKPFTPR | | Bait Uniprot Accession | Q8SWR8 | | Bait Uniprot Identifier | ATX2_DROME | | Bait Gene Name | Atx2 | | Sequence Position | 857-869 | | Critical Residues | P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 20590 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16835262 | | Comments | The PABP-interacting motif 2 (PAM2) in the Drosophila melanogaster Ataxin-2 homolog (Datx2) that mediates binding to the MLLE domain of Drosophila Polyadenylate-binding protein (pAbp) |
Record No : 63 |
| Instance ID | 10626 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | TNDSLL | | Bait Uniprot Accession | P07550 | | Bait Uniprot Identifier | ADRB2_HUMAN | | Bait Gene Name | ADRB2 | | Sequence Position | 408-413 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Far Western blotting; Mutation analysis; X-ray crystallography | | Interaction ID | 20626 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11882663 | | Comments | The amino-terminal PDZ domain of human Na(+)/H(+) exchange regulatory cofactor NHERF1 (SLC9A3R1), referred to as PDZ1, binds with high affinity to the C-terminal PDZ domain-binding motif of human Beta-2 adrenergic receptor |
Record No : 64 |
| Instance ID | 10640 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | WDETNL | | Bait Uniprot Accession | O55043 | | Bait Uniprot Identifier | ARHG7_RAT | | Bait Gene Name | Arhgef7 | | Sequence Position | 641-646 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20640 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20117114 | | Comments | C-terminal class 1 PDZ-binding motif in rat Beta-Pix/p21-activated kinase interacting exchange factor/Arhgef7 that binds to the rat Shank1 PDZ domain through an extensive beta-sheet interaction |
Record No : 65 |
| Instance ID | 10650 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | DRETDV | | Bait Uniprot Accession | P26672 | | Bait Uniprot Identifier | A46_VACCW | | Bait Gene Name | A46R | | Sequence Position | 235-240 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Display technology | | Interaction ID | 20650 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18828675 | | Comments | C-terminal class 1 PDZ-binding motif in the A46 protein of Vaccinia virus that binds to the human Scribble (SCRIB) PDZ domain |
Record No : 66 |
| Instance ID | 10653 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | YLVTSV | | Bait Uniprot Accession | Q61315 | | Bait Uniprot Identifier | APC_MOUSE | | Bait Gene Name | Apc | | Sequence Position | 2840-2845 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | NMR | | Interaction ID | 20653 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17161370 | | Comments | C-terminal class 1 PDZ-binding motif in mouse Adenomatous polyposis coli protein (Apc) that binds to the PDZ domain of mouse Protein tyrosine phosphatase PTP-BL (Ptpn13) |
Record No : 67 |
| Instance ID | 10665 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | LWETSI | | Bait Uniprot Accession | Q9P0K1 | | Bait Uniprot Identifier | ADA22_HUMAN | | Bait Gene Name | ADAM22 | | Sequence Position | 901-906 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Co-IP; Co-IP; Mutation analysis | | Interaction ID | 20665 | | Interacting Domain | PDZ domain | | Disease Association(s) | Epilepsy | | Inhibitor(s) | Unknown | | Reference(s) | 16990550 | | Comments | C-terminal PDZ domain-binding motif in human Metalloproteinase-disintegrin ADAM22 that mediates binding to the PDZ domain of human Leucine-rich glioma-inactivated protein 1/ Epitempin-1 (LGI1) |
Record No : 68 |
| Instance ID | 10666 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | SLETSL | | Bait Uniprot Accession | Q01814 | | Bait Uniprot Identifier | AT2B2_HUMAN | | Bait Gene Name | ATP2B2 | | Sequence Position | 1238-1243 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Y2H; Pull down; Co-IP; Colocalization | | Interaction ID | 20666 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11786550 | | Comments | C-terminal PDZ domain-binding motif in human Plasma membrane calcium-transporting ATPase 2 (ATP2B2) that mediates binding to the PDZ domain of human Sodium-hydrogen exchanger regulatory cofactor NHERF-2 (SLC9A3R2) |
Record No : 69 |
| Instance ID | 10674 | | Regular Expression | xxx[VLIFY]x[ACVILF]$ | | Motif Instance | EQPVYI | | Bait Uniprot Accession | Q02410 | | Bait Uniprot Identifier | APBA1_HUMAN | | Bait Gene Name | APBA1 | | Sequence Position | 832-837 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Y2H; NMR; Mutation analysis | | Interaction ID | 20674 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16007100 | | Comments | The highly conserved C-terminal tail of human Adapter protein X11alpha folds back and inserts into the target-binding groove of its first PDZ domain forming an autoinhibited conformation |
Record No : 70 |
| Instance ID | 10689 | | Regular Expression | [DEN][DEN]x{2,3}[ILMVA][DEN][DEN]L | | Motif Instance | EEAALDDL | | Bait Uniprot Accession | Q8WXE1 | | Bait Uniprot Identifier | ATRIP_HUMAN | | Bait Gene Name | ATRIP | | Sequence Position | 769-776 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20689 | | Interacting Domain | HEAT repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15758953 | | Comments | Conserved carboxy-terminal motif in human ATR-interacting protein (ATRIP) that is required for its interaction with human Serine/threonine-protein kinase ATR |
Record No : 71 |
| Instance ID | 10708 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | SPKGVLFS | | Bait Uniprot Accession | Q92667 | | Bait Uniprot Identifier | AKAP1_HUMAN | | Bait Gene Name | AKAP1 | | Sequence Position | 151-158 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Affinity chromatography technology; Far Western blotting; Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20708 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10995432 | | Comments | The RVXF motif of human A-kinase anchoring protein AKAP149 (AKAP1) that mediates binding to the catalytic subunit of protein phosphatase 1 (PPP1CA) whereby AKAP149 recruits PP1 at the nuclear envelope (NE) upon somatic nuclear reformation, a prerequisite for assembly of B-type lamins |
Record No : 72 |
| Instance ID | 10735 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | GYENPTYK | | Bait Uniprot Accession | P05067 | | Bait Uniprot Identifier | A4_HUMAN | | Bait Gene Name | APP | | Sequence Position | 756-763 | | Critical Residues | P2; P3 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Mutation analysis; SPR; X-ray crystallography | | Interaction ID | 20735 | | Interacting Domain | PTB domain | | Disease Association(s) | Alzheimer's disease; Cerebral amyloid angiopathy | | Inhibitor(s) | Unknown | | Reference(s) | 10373567, 9321393, 18833287, 8887653 | | Comments | The phosphotyrosine-binding domain (PTB) of the human adaptor protein X11alpha/MINT1/APBA1 binds to the the NPxY PTB-binding motif of Human amyloid precursor protein (APP) |
Record No : 73 |
| Instance ID | 10736 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | GYENPTYK | | Bait Uniprot Accession | P05067 | | Bait Uniprot Identifier | A4_HUMAN | | Bait Gene Name | APP | | Sequence Position | 756-763 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | NMR; X-ray crystallography; ITC | | Interaction ID | 20736 | | Interacting Domain | PTB domain | | Disease Association(s) | Alzheimer's disease; Cerebral amyloid angiopathy | | Inhibitor(s) | Unknown | | Reference(s) | 10373567, 9321393, 18833287, 8887653 | | Comments | The interaction of the C-terminal phosphotyrosine-binding (PTB) domain of the human adaptor protein FE65/APBB1 with the NPxY PTB-binding motif of human amyloid precursor protein (APP), mediates APP trafficking and signalling, and is thought to regulate APP processing |
Record No : 74 |
| Instance ID | 10737 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | GYENPTYK | | Bait Uniprot Accession | P05067 | | Bait Uniprot Identifier | A4_HUMAN | | Bait Gene Name | APP | | Sequence Position | 756-763 | | Critical Residues | P1; P2; P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Filter binding assay; Fluorescence anisotropy; Y2H | | Interaction ID | 20737 | | Interacting Domain | PTB domain | | Disease Association(s) | Alzheimer's disease; Cerebral amyloid angiopathy | | Inhibitor(s) | Unknown | | Reference(s) | 10373567, 9321393, 18833287, 8887653 | | Comments | The amino-terminal phosphotyrosine-binding (PTB) domain of human Disabled homolog 1 (DAB1) binds specifically to the transmembrane glycoproteins of the human amyloid precursor protein (APP) through the NPXY motif but does not bind to tyrosine-phosphorylated peptide ligands |
Record No : 75 |
| Instance ID | 10744 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | GYENPTYK | | Bait Uniprot Accession | P08592 | | Bait Uniprot Identifier | A4_RAT | | Bait Gene Name | App | | Sequence Position | 756-763 | | Critical Residues | P2; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | X-ray crystallography; Mutation analysis | | Interaction ID | 20744 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12826668 | | Comments | Interaction of the phosphotyrosine-binding (PTB) domain of mouse Disabled homolog 1 (Dab1) with the NPXY motif of the rat amyloid precursor protein (App) |
Record No : 76 |
| Instance ID | 10745 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | GYENPTYK | | Bait Uniprot Accession | P12023 | | Bait Uniprot Identifier | A4_MOUSE | | Bait Gene Name | App | | Sequence Position | 756-763 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | ITC; Mutation analysis; NMR | | Interaction ID | 20745 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18650440 | | Comments | Interaction of the C-terminal phosphotyrosine-binding (PTB) domain of the mouse adaptor protein Fe65L1/Apbb2 with the NPxY PTB-binding motif of mouse amyloid precursor protein (App) |
Record No : 77 |
| Instance ID | 10776 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LYCAE | | Bait Uniprot Accession | P35869 | | Bait Uniprot Identifier | AHR_HUMAN | | Bait Gene Name | AHR | | Sequence Position | 331-335 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20776 | | Interacting Domain | B domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 10644764 | | Comments | The LxCxE motif in the Human dioxin aromatic hydrocarbon receptor (AHR) that mediates binding to a highly conserved shallow groove in the B domain of the human retinoblastoma protein (RB) |
Record No : 78 |
| Instance ID | 10784 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LVCHE | | Bait Uniprot Accession | P29374 | | Bait Uniprot Identifier | ARI4A_HUMAN | | Bait Gene Name | ARID4A | | Sequence Position | 957-961 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding | | Interaction ID | 20784 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8414517 | | Comments | The Rb-binding LxCxE motif in the Human Retinoblastoma-binding protein 1 (RBP1/ARID4A) that mediates binding to the human retinoblastoma protein (RB) |
Record No : 79 |
| Instance ID | 10836 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGICMS | | Bait Uniprot Accession | P18848 | | Bait Uniprot Identifier | ATF4_HUMAN | | Bait Gene Name | ATF4 | | Sequence Position | 218-224 | | Critical Residues | P1; P2 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P7 | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis; Radiolabel; Protein kinase assay | | Interaction ID | 20836 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11238952 | | Comments | Degradation of human cAMP-dependent transcription factor ATF4 relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase via the DSGxxS phospho-dependent degron |
Record No : 80 |
| Instance ID | 10848 | | Regular Expression | (Y)xNx | | Motif Instance | YENP | | Bait Uniprot Accession | P05067 | | Bait Uniprot Identifier | A4_HUMAN | | Bait Gene Name | APP | | Sequence Position | 757-760 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Beta turn | | Experimental Method(s) | SPR; Pull down; Western blot | | Interaction ID | 20848 | | Interacting Domain | SH2 domain | | Disease Association(s) | Alzheimer's disease | | Inhibitor(s) | Unknown | | Reference(s) | 19602287 | | Comments | Phosphorylation of Tyr-757 in the intracellular domain (AID) of Human amyloid beta precursor protein (APP) creates a docking site for the SH2-domain of the human Adapter protein GRB2 |
Record No : 81 |
| Instance ID | 10896 | | Regular Expression | PxxPx[KR] | | Motif Instance | PAPPSR | | Bait Uniprot Accession | Q13444 | | Bait Uniprot Identifier | ADA15_HUMAN | | Bait Gene Name | ADAM15 | | Sequence Position | 767-772 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Peptide array; Solid phase assay; Mutation analysis | | Interaction ID | 20896 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19718658 | | Comments | The consensus class II SH3-binding motif in Human Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15), that interacts with the SH3 domain of Human Proto-oncogene tyrosine-protein kinase Src (SRC) |
Record No : 82 |
| Instance ID | 10912 | | Regular Expression | PxxDY | | Motif Instance | PPVDY | | Bait Uniprot Accession | Q8IZP0 | | Bait Uniprot Identifier | ABI1_HUMAN | | Bait Gene Name | ABI1 | | Sequence Position | 417-421 | | Critical Residues | P1; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Far-western blotting; ELISA; Pull down(GST tag) | | Interaction ID | 20912 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10508163 | | Comments | The SH3 domain of human Epidermal growth factor receptor kinase substrate 8 (EPS8) binds to the PXXDY consensus motif found in human Abl interactor 1 (ABI1) or e3B1 |
Record No : 83 |
| Instance ID | 10919 | | Regular Expression | xPxAxVxP[^P] | | Motif Instance | KPTAYVRPM | | Bait Uniprot Accession | Q9UHB7 | | Bait Uniprot Identifier | AFF4_HUMAN | | Bait Gene Name | AFF4 | | Sequence Position | 252-260 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 20919 | | Interacting Domain | TRAF-like domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15459319 | | Comments | The PxAxVxP motif in human AFF4 that mediates binding to and degradation by human E3 ubiquitin-protein ligase SIAH1 |
Record No : 84 |
| Instance ID | 10933 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFTVS | | Bait Uniprot Accession | Q80YE4 | | Bait Uniprot Identifier | LMTK1_MOUSE | | Bait Gene Name | Aatk | | Sequence Position | 1336-1340 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Mutation analysis | | Interaction ID | 20933 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17267545 | | Comments | The regulatory domain of mouse stress-related kinase Stk39/Spak interacts with the regulatory domain of mouse Apoptosis-associated tyrosine kinase (Aatk/AATYK) through the RFxV docking motif (1336-1340) in the extreme COOH-terminus of AATYK |
Record No : 85 |
| Instance ID | 10934 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFSIT | | Bait Uniprot Accession | Q80YE4 | | Bait Uniprot Identifier | LMTK1_MOUSE | | Bait Gene Name | Aatk | | Sequence Position | 1346-1350 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Mutation analysis | | Interaction ID | 20934 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17267545 | | Comments | The regulatory domain of mouse stress-related kinase Stk39/Spak interacts with the regulatory domain of mouse Apoptosis-associated tyrosine kinase (Aatk/AATYK) through the RFxV docking motif (1346-1350) in the extreme COOH-terminus of AATYK |
Record No : 86 |
| Instance ID | 10966 | | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | | Motif Instance | VIDLT | | Bait Uniprot Accession | Q6VMQ6 | | Bait Uniprot Identifier | MCAF1_HUMAN | | Bait Gene Name | ATF7IP | | Sequence Position | 966-970 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Y2H; NMR | | Interaction ID | 20966 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16524884, 18842587 | | Comments | The SUMO-interacting motif (SIM) of human MBD1-containing chromatin-associated factor 1 (MCAF1) or ATF7IP, a transcription repressor, that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1) |
Record No : 87 |
| Instance ID | 10988 | | Regular Expression | ([KR][^ED]{0,5}[ST]xIP[^ED]{5,5})|([^ED]{5,5}[ST]xIP[^ED]{0,5}[KR]) | | Motif Instance | RPSQIPTPVNN | | Bait Uniprot Accession | P25054 | | Bait Uniprot Identifier | APC_HUMAN | | Bait Gene Name | APC | | Sequence Position | 2801-2811 | | Critical Residues | P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | NMR; Pull down; Classical fluorescence spectroscopy; ITC; Mutation analysis | | Interaction ID | 20988 | | Interacting Domain | EBH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15616574 | | Comments | The C-terminal EBH domain of human End-binding protein 1 (EB1) or MAPRE1 binds to the C-terminal SxIP motif of human Adenomatous polyposis coli (APC) tumor suppressor |
Record No : 88 |
| Instance ID | 11005 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | PRPPVPGE | | Bait Uniprot Accession | O15169 | | Bait Uniprot Identifier | AXIN1_HUMAN | | Bait Gene Name | AXIN1 | | Sequence Position | 21-28 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Fluorescence polarization spectroscopy; Alanine scanning | | Interaction ID | 21005 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19759537, 22153077 | | Comments | The ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-1 (TNKS) interacts with the Tankyrase-binding motif in human AXIN1 |
Record No : 89 |
| Instance ID | 11006 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | PRPPVPGE | | Bait Uniprot Accession | O15169 | | Bait Uniprot Identifier | AXIN1_HUMAN | | Bait Gene Name | AXIN1 | | Sequence Position | 21-28 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Fluorescence polarization spectroscopy; Alanine scanning | | Interaction ID | 21006 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19759537, 22153077 | | Comments | The N-terminal region of ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif in human AXIN1 |
Record No : 90 |
| Instance ID | 11035 | | Regular Expression | [KR]{1,4}[KR]x[KR]Wx | | Motif Instance | RKRRWS | | Bait Uniprot Accession | P54253 | | Bait Uniprot Identifier | ATX1_HUMAN | | Bait Gene Name | ATXN1 | | Sequence Position | 770-775 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; ITC; Competition binding | | Interaction ID | 21035 | | Interacting Domain | UHM domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20037628 | | Comments | Human Ataxin-1 (ATXN1), a member of the polyglutamine (polyQ) expanded protein family, interacts with and influences the function of the splicing factor U2AF65 (U2AF2) via its UHM ligand motif (ULM) |
Record No : 91 |
| Instance ID | 11067 | | Regular Expression | PPxY | | Motif Instance | PPEY | | Bait Uniprot Accession | Q4VCS5 | | Bait Uniprot Identifier | AMOT_HUMAN | | Bait Gene Name | AMOT | | Sequence Position | 239-242 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Co-IP; Mutation analysis | | Interaction ID | 21067 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21205866 | | Comments | The PPXY motif of human Angiomotin (AMOT), a component of the Hippo tumor suppressor pathway, that binds to the WW domain of human transcription coactivator Yes-associated protein (YAP1/YAP65), thereby inhibiting YAP oncoprotein through phosphorylation-induced cytoplasmic retention and degradation |
Record No : 92 |
| Instance ID | 11103 | | Regular Expression | xxx([ST])Px | | Motif Instance | HVETPE | | Bait Uniprot Accession | P31749 | | Bait Uniprot Identifier | AKT1_HUMAN | | Bait Gene Name | AKT1 | | Sequence Position | 89-94 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Pull down; Alanine scanning | | Interaction ID | 21103 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19448664 | | Comments | The human oncogenic Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Thr-92-Pro motif of human serine/threonine Protein kinase B alpha (PKB alpha, also known as AKT1/Proto-oncogene c-Akt) to protect Akt from degradation |
Record No : 93 |
| Instance ID | 11104 | | Regular Expression | xxx([ST])Px | | Motif Instance | ITITPP | | Bait Uniprot Accession | P31749 | | Bait Uniprot Identifier | AKT1_HUMAN | | Bait Gene Name | AKT1 | | Sequence Position | 447-452 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Pull down; Alanine scanning | | Interaction ID | 21104 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19448664 | | Comments | The human oncogenic Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Thr-450-Pro motif of human serine/threonine Protein kinase B alpha (PKB alpha, also known as AKT1/Proto-oncogene c-Akt) to protect Akt from degradation |
Record No : 94 |
| Instance ID | 11112 | | Regular Expression | xxx([ST])Px | | Motif Instance | SAKTPG | | Bait Uniprot Accession | Q9NY61 | | Bait Uniprot Identifier | AATF_HUMAN | | Bait Gene Name | AATF | | Sequence Position | 143-148 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Co-IP; Pull down; Alanine scanning | | Interaction ID | 21112 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17468107 | | Comments | In response to apoptotic stimuli, human Peptidyl-prolyl cis-trans isomerase PIN1 binds the phosphorylated Thr-146-Pro motif of human Rb-binding protein CHE1/AATF and affects its stability by increasing its capacity to interact with HDM2 |
Record No : 95 |
| Instance ID | 11119 | | Regular Expression | xxx([ST])Px | | Motif Instance | KPRSPV | | Bait Uniprot Accession | Q99MK8 | | Bait Uniprot Identifier | ARBK1_MOUSE | | Bait Gene Name | Adrbk1 | | Sequence Position | 667-672 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Radiolabel; Alanine scanning; Co-IP; Pull down(GST tag) | | Interaction ID | 21119 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20080565 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the Ser-670-Pro motif of mouse G-protein-coupled receptor kinase 2 (Grk2/Adrbk1) for its subsequent degradation |
Record No : 96 |
| Instance ID | 11147 | | Regular Expression | xxx([ST])Px | | Motif Instance | AAVTPE | | Bait Uniprot Accession | P05067 | | Bait Uniprot Identifier | A4_HUMAN | | Bait Gene Name | APP | | Sequence Position | 740-745 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot | | Interaction ID | 21147 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19602287 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds human Amyloid beta A4 protein (APP) phosphorylated on Thr-743 and regulates APP processing |
Record No : 97 |
| Instance ID | 11151 | | Regular Expression | xxx([ST])Px | | Motif Instance | DSGTPL | | Bait Uniprot Accession | O82794 | | Bait Uniprot Identifier | AGL24_ARATH | | Bait Gene Name | AGL24 | | Sequence Position | 199-204 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence technology; NMR; Alanine scanning; Co-IP; Phosphatase assay; Pull down | | Interaction ID | 21151 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20129060 | | Comments | Arabidopsis Peptidyl-prolyl cis-trans isomerase Pin1/PIN1At interacts with the phosphorylated Thr-202-Pro motif of Arabidopsis MADS-box protein AGL24 and thereby regulates flowering time in Arabidopsis |
Record No : 98 |
| Instance ID | 11196 | | Regular Expression | xF[^P][^P][KRIL]H[^P][^P][YLMFH][^P]xxx | | Motif Instance | SFQQRHESLRPAA | | Bait Uniprot Accession | Q9UKG1 | | Bait Uniprot Identifier | DP13A_HUMAN | | Bait Gene Name | APPL1 | | Sequence Position | 403-415 | | Critical Residues | P2; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation disrupting interaction; Sequence based prediction; Co-IP; Pull down(GST tag); ITC; SPR; Colocalization; Competition binding | | Interaction ID | 21196 | | Interacting Domain | ASH-RhoGAP-like domain | | Disease Association(s) | Lowe syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 21233288, 18307981, 17765681, 20133602, 21666675 | | Comments | The conserved F and H motif in human DCC-interacting protein 13-alpha (DIP13A/APPL1) that binds to the ASH-RhoGAP-like domain of human OCRL1 |
Record No : 99 |
| Instance ID | 11202 | | Regular Expression | [ED][ED][ED]x[IV]Yx | | Motif Instance | EEENIYS | | Bait Uniprot Accession | Q91YM2 | | Bait Uniprot Identifier | RHG35_MOUSE | | Bait Gene Name | Arhgap35 | | Sequence Position | 1100-1106 | | Critical Residues | P2; P3; P5; P6 | | Motif PTM(s) | Phosphorylation at Tyr-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed Mutagenesis; In-vitro assay using fluorogenic peptide probes | | Interaction ID | 21202 | | Interacting Domain | Catalytic domain of Ptprz | | Disease Association(s) | Impaired hippocampus-dependent contextual fear mem | | Inhibitor(s) | Unknown | | Reference(s) | 21890632 | | Comments | Consensus sequence for association with protein-tyrosine phosphatase receptor type zeta in mouse Rho GTPase-activating protein 35 (Arhgap35) |
Record No : 100 |
| Instance ID | 11226 | | Regular Expression | [ST]x[VL]D | | Motif Instance | SSVD | | Bait Uniprot Accession | Q01484 | | Bait Uniprot Identifier | ANK2_HUMAN | | Bait Gene Name | ANK2 | | Sequence Position | 88-91 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21226 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22876914 | | Comments | Novel internal motif identified in human Ankyrin-2 that is recognized by human Glutaminase-interacting protein (GIP), also known as Tax-interacting protein 1 (TIP1) or Tax1-binding protein 3 (TAX1BP3), composed almost exclusively of a single PDZ domain |
Record No : 101 |
| Instance ID | 11230 | | Regular Expression | [ST]x[VL]D | | Motif Instance | SSVD | | Bait Uniprot Accession | O95352 | | Bait Uniprot Identifier | ATG7_HUMAN | | Bait Gene Name | ATG7 | | Sequence Position | 331-334 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21230 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22876914 | | Comments | Novel internal motif identified in human Ubiquitin-like modifier-activating enzyme ATG7 that is recognized by human Glutaminase-interacting protein (GIP), also known as Tax-interacting protein 1 (TIP1) or Tax1-binding protein 3 (TAX1BP3), composed almost exclusively of a single PDZ domain |
Record No : 102 |
| Instance ID | 11231 | | Regular Expression | [ST]x[VL]D | | Motif Instance | SSVD | | Bait Uniprot Accession | Q9BRR9 | | Bait Uniprot Identifier | RHG09_HUMAN | | Bait Gene Name | ARHGAP9 | | Sequence Position | 381-384 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21231 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22876914 | | Comments | Novel internal motif identified in human Rho GTPase-activating protein 9 (ARHGAP9) that is recognized by human Glutaminase-interacting protein (GIP), also known as Tax-interacting protein 1 (TIP1) or Tax1-binding protein 3 (TAX1BP3), composed almost exclusively of a single PDZ domain |
Record No : 103 |
| Instance ID | 11288 | | Regular Expression | [KR]xTQTx | | Motif Instance | KSTQTC | | Bait Uniprot Accession | Q9EMM2 | | Bait Uniprot Identifier | Q9EMM2_AMEPV | | Bait Gene Name | AMV179 | | Sequence Position | 154-159 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21288 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12782328 | | Comments | The LC8 dynein light chain binding motif in the product of the AMV179 gene of an insect poxvirus that binds to the rat 8 kDa Dynein light chain 1 (Dynll1) |
Record No : 104 |
| Instance ID | 11342 | | Regular Expression | SxxF | | Motif Instance | SPQF | | Bait Uniprot Accession | Q8WXE1 | | Bait Uniprot Identifier | ATRIP_HUMAN | | Bait Gene Name | ATRIP | | Sequence Position | 239-242 | | Critical Residues | P1; P4 | | Motif PTM(s) | Phosphorylation at Ser-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; ITC | | Interaction ID | 21342 | | Interacting Domain | BRCT domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 14578343, 24073851, 17616665 | | Comments | Motif responsible for ATRIP-BRCA1 interaction monitoring DNA replication checkpoint |
Record No : 105 |
| Instance ID | 11464 | | Regular Expression | FxxLF | | Motif Instance | FQNLF | | Bait Uniprot Accession | P10275 | | Bait Uniprot Identifier | ANDR_HUMAN | | Bait Gene Name | AR | | Sequence Position | 23-27 | | Critical Residues | P1; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Mammalian two-hybrid assay; GST interaction assay | | Interaction ID | 21464 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10816582 | | Comments | The FXXLF sequence in the N-terminal domain of Androgen receptor(AR), the predominant androgen-dependent interaction site, that interacts with AF2 and mediates a direct interaction between the N-terminal and C-terminal regions of AR to stabilize the hormone-receptor complex for AR-mediated transcriptional activation |
Record No : 106 |
| Instance ID | 11465 | | Regular Expression | WxxLF | | Motif Instance | WHTLF | | Bait Uniprot Accession | P10275 | | Bait Uniprot Identifier | ANDR_HUMAN | | Bait Gene Name | AR | | Sequence Position | 433-437 | | Critical Residues | P1; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Mammalian two-hybrid assay; GST interaction assay | | Interaction ID | 21465 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10816582 | | Comments | The WXXLF sequence in the N-terminal domain of Androgen receptor(AR), a second androgen-independent interaction site, that probably interacts with a region of the LBD outside of AF2 and mediates a direct interaction between the N-terminal and C-terminal regions of AR |
Record No : 107 |
| Instance ID | 11483 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TSV | | Bait Uniprot Accession | P25054 | | Bait Uniprot Identifier | APC_HUMAN | | Bait Gene Name | APC | | Sequence Position | 2841-2843 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | SPR; Pull down(GST tag) | | Interaction ID | 21483 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11029657 | | Comments | PDZ domain binding C-terminal S/TXV motif in APC that binds to the second PDZ domain (PDZ2) of PSD-95(DLG4) protein |
Record No : 108 |
| Instance ID | 11492 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | SDL | | Bait Uniprot Accession | O43707 | | Bait Uniprot Identifier | ACTN4_HUMAN | | Bait Gene Name | ACTN4 | | Sequence Position | 909-911 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21492 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12042308 | | Comments | Consensus PDZ-binding motif at the extreme C-terminus of Alpha-actinin-4 which interacts with the fifth PDZ domain of MAGI-1 |
Record No : 109 |
| Instance ID | 11667 | | Regular Expression | D[ST]xL$ | | Motif Instance | DSLL | | Bait Uniprot Accession | P07550 | | Bait Uniprot Identifier | ADRB2_HUMAN | | Bait Gene Name | ADRB2 | | Sequence Position | 410-413 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Ligand Overlay Assay | | Interaction ID | 21667 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9560162, 9671706 | | Comments | C-terminal PDZ domain-binding motif in human Beta-2 adrenergic receptor that mediates binding to the first PDZ domain of the Na+/H+ exchanger regulatory factor (NHERF) and may play a role in beta2-adrenergic receptor-mediated regulation of Na+/H+ exchange |
Record No : 110 |
| Instance ID | 11684 | | Regular Expression | Wx{2,3}[FW] | | Motif Instance | WDLW | | Bait Uniprot Accession | P49418 | | Bait Uniprot Identifier | AMPH_HUMAN | | Bait Gene Name | AMPH | | Sequence Position | 382-385 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21684 | | Interacting Domain | Gamma-adaptin ear(GAE) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14973137 | | Comments | GAE-binding motif in Amphiphysin that interacts with the gamma-ear domain of the AP-1 complex subunit gamma-1 or Gamma1-adaptin |
Record No : 111 |
| Instance ID | 11685 | | Regular Expression | Wx{2,3}[FW] | | Motif Instance | WENDF | | Bait Uniprot Accession | Q63HQ0 | | Bait Uniprot Identifier | AP1AR_HUMAN | | Bait Gene Name | AP1AR | | Sequence Position | 260-264 | | Critical Residues | P1; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag); Peptide binding assay | | Interaction ID | 21685 | | Interacting Domain | Gamma-adaptin ear(GAE) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19965873 | | Comments | AP-1-binding motif in AP-1 complex-associated regulatory protein that binds to the gamma-ear domain of the AP-1 complex subunit gamma-1 or Gamma1-adaptin |
Record No : 112 |
| Instance ID | 11695 | | Regular Expression | Wx{2,3}[FW] | | Motif Instance | WNPF | | Bait Uniprot Accession | P0C1X8 | | Bait Uniprot Identifier | AAK1_RAT | | Bait Gene Name | Aak1 | | Sequence Position | 696-699 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21695 | | Interacting Domain | Alpha-ear domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14565955, 11877461 | | Comments | AP-2 interaction motif in rat AP2-associated protein kinase 1 (Aak1) that mediates binding to the alpha-ear domain of rat protein Ap2a1 |
Record No : 113 |
| Instance ID | 11766 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RPPPPPP | | Bait Uniprot Accession | Q9ULH1 | | Bait Uniprot Identifier | ASAP1_HUMAN | | Bait Gene Name | ASAP1 | | Sequence Position | 826-832 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; NMR; Size exclusion chromatography; Dynamic light-scattering analysis | | Interaction ID | 21766 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16636290 | | Comments | The SH3 domain-binding motif in human ASAP1 protein that binds the human cortactin SH3 domain |
Record No : 114 |
| Instance ID | 11795 | | Regular Expression | LA[HQN]GLLQLG[HQN]GL | | Motif Instance | LANGLLQLGHGL | | Bait Uniprot Accession | Q9Y5C1 | | Bait Uniprot Identifier | ANGL3_HUMAN | | Bait Gene Name | ANGPTL3 | | Sequence Position | 46-57 | | Critical Residues | P3; P7; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Coiled-coil | | Experimental Method(s) | Mutational analysis; Sequence based prediction | | Interaction ID | 21795 | | Interacting Domain | Unknown | | Disease Association(s) | Dyslipidemia | | Inhibitor(s) | Unknown | | Reference(s) | 19246456 | | Comments | The highly conserved 12-amino acid consensus motif involved in Angptl3-mediated LPL inhibition in humans |
Record No : 115 |
| Instance ID | 11796 | | Regular Expression | LA[HQN]GLLQLG[HQN]GL | | Motif Instance | LAHGLLQLGQGL | | Bait Uniprot Accession | Q9BY76 | | Bait Uniprot Identifier | ANGL4_HUMAN | | Bait Gene Name | ANGPTL4 | | Sequence Position | 44-55 | | Critical Residues | P3; P7; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Coiled-coil | | Experimental Method(s) | Mutational analysis; Sequence based prediction | | Interaction ID | 21796 | | Interacting Domain | Unknown | | Disease Association(s) | Dyslipidemia | | Inhibitor(s) | Unknown | | Reference(s) | 19246456 | | Comments | The highly conserved 12-amino acid consensus motif involved in Angptl4-mediated LPL inhibition in humans |
Record No : 116 |
| Instance ID | 11815 | | Regular Expression | [RK]x{0,1}[VIL][^P][FW] | | Motif Instance | KGVLF | | Bait Uniprot Accession | Q92667 | | Bait Uniprot Identifier | AKAP1_HUMAN | | Bait Gene Name | AKAP1 | | Sequence Position | 153-157 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21815 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10995432 | | Comments | PP1-binding motif of human A-kinase anchor protein 1 that mediates interaction with human protein phosphatase PP1 |
Record No : 117 |
| Instance ID | 11971 | | Regular Expression | Fxx[RK]x[RK] | | Motif Instance | FKRRKK | | Bait Uniprot Accession | P24588 | | Bait Uniprot Identifier | AKAP5_HUMAN | | Bait Gene Name | AKAP5 | | Sequence Position | 37-42 | | Critical Residues | P1; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down; Peptide Binding assay; Competition binding assay; SPR | | Interaction ID | 21971 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21561082 | | Comments | Consensus PP1 targeting motif in the neuronally expressed anchoring protein AKAP79 that mediates a high-affinity interaction between AKAP79 and PP1-alpha catalytic subunit, which may direct PP1 activity toward specific targets |
Record No : 118 |
| Instance ID | 12033 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | CAGTQTD | | Bait Uniprot Accession | Q9XZ31 | | Bait Uniprot Identifier | Q9XZ31_DROME | | Bait Gene Name | ana2 | | Sequence Position | 161-167 | | Critical Residues | P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Mutational analysis; ITC | | Interaction ID | 22033 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24920673 | | Comments | The signature TQT motif (LC8-binding site 1) in Drosophila Anastral spindle 2 (ana2) that binds to the Drosophila LC8 (or ctp) for proper spindle positioning |
Record No : 119 |
| Instance ID | 12034 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | STTGTQCD | | Bait Uniprot Accession | Q9XZ31 | | Bait Uniprot Identifier | Q9XZ31_DROME | | Bait Gene Name | ana2 | | Sequence Position | 238-245 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; ITC | | Interaction ID | 22034 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24920673 | | Comments | The signature TQT motif (LC8-binding site 2) in Drosophila Anastral spindle 2 (ana2) that binds to the Drosophila LC8 (or ctp) for proper spindle positioning |
Record No : 120 |
| Instance ID | 12038 | | Regular Expression | [DE][DE]FEDAx[DE] | | Motif Instance | EEFEDAPD | | Bait Uniprot Accession | O43681 | | Bait Uniprot Identifier | ASNA_HUMAN | | Bait Gene Name | ASNA1 | | Sequence Position | 13-20 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22038 | | Interacting Domain | MSP domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24885147 | | Comments | FFAT-like motif in human ATPase ASNA1 that allows it to interact directly with the MSP domain of human Vesicle-associated membrane protein-associated protein B/C (VAPB) |
Record No : 121 |
| Instance ID | 12068 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | EKSTKL | | Bait Uniprot Accession | O43572 | | Bait Uniprot Identifier | AKA10_HUMAN | | Bait Gene Name | AKAP10 | | Sequence Position | 657-662 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; Peptide Array Screening | | Interaction ID | 22068 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25348485 | | Comments | The six C-terminal residues of human Dual specificity A kinase-anchoring protein 2 (D-AKAP-2) or AKAP10 represent a C-terminal class 1 PDZ-binding motif that binds to the third and fourth PDZ domains of human Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1) |
Record No : 122 |
| Instance ID | 12069 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | EKSTKL | | Bait Uniprot Accession | O43572 | | Bait Uniprot Identifier | AKA10_HUMAN | | Bait Gene Name | AKAP10 | | Sequence Position | 657-662 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Peptide Array Screening | | Interaction ID | 22069 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25348485 | | Comments | The six C-terminal residues of human Dual specificity A kinase-anchoring protein 2 (D-AKAP-2) or AKAP10 represent a C-terminal class 1 PDZ-binding motif that binds to the third and fourth PDZ domains of human Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) |
Record No : 123 |
| Instance ID | 12070 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | EKSTKL | | Bait Uniprot Accession | O43572 | | Bait Uniprot Identifier | AKA10_HUMAN | | Bait Gene Name | AKAP10 | | Sequence Position | 657-662 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Peptide Array Screening | | Interaction ID | 22070 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25348485 | | Comments | The six C-terminal residues of human Dual specificity A kinase-anchoring protein 2 (D-AKAP-2) or AKAP10 represent a C-terminal class 1 PDZ-binding motif that binds to the third and fourth PDZ domains of human Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (SLC9A3R2) |
Record No : 124 |
| Instance ID | 12163 | | Regular Expression | [LIVY]R[KRW][RKL]Rxxx[FKLY] | | Motif Instance | LRKRREAYF | | Bait Uniprot Accession | P54252 | | Bait Uniprot Identifier | ATX3_HUMAN | | Bait Gene Name | ATXN3 | | Sequence Position | 281-289 | | Critical Residues | P2; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag); Competition binding; Peptide Array Screening | | Interaction ID | 22163 | | Interacting Domain | Unknown | | Disease Association(s) | Spinocerebellar ataxia type 3 | | Inhibitor(s) | Unknown | | Reference(s) | 16525503 | | Comments | The VCP-binding motif (VBM) in Human Ataxin-3 (ATXN3) that is critical for binding to human Transitional endoplasmic reticulum ATPase VCP |
Record No : 125 |
| Instance ID | 12166 | | Regular Expression | Rx{0,3}AxAAxxR | | Motif Instance | RRMLAAAAERR | | Bait Uniprot Accession | Q9R049 | | Bait Uniprot Identifier | AMFR_MOUSE | | Bait Gene Name | Amfr | | Sequence Position | 626-636 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22166 | | Interacting Domain | ND1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16987818 | | Comments | The VCP-interacting motif (VIM) in mouse E3 ubiquitin-protein ligase Amfr (gp78) that mediates interaction with mouse Transitional endoplasmic reticulum ATPase (TER ATPase) Vcp |
Record No : 126 |
| Instance ID | 12168 | | Regular Expression | Rx{0,3}AxAAxxR | | Motif Instance | RALAAERR | | Bait Uniprot Accession | Q80UU1 | | Bait Uniprot Identifier | ANKZ1_MOUSE | | Bait Gene Name | Ankzf1 | | Sequence Position | 680-687 | | Critical Residues | P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22168 | | Interacting Domain | ND1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21070972 | | Comments | The VCP-interacting motif (VIM) in mouse Ankyrin repeat and zinc finger domain-containing protein 1 (Ankzf1/vms-1) that mediates interaction with mouse Transitional endoplasmic reticulum ATPase (TER ATPase) Vcp |
Record No : 127 |
| Instance ID | 12184 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YGRDFLL | | Bait Uniprot Accession | Q9UNK9 | | Bait Uniprot Identifier | ANGE1_HUMAN | | Bait Gene Name | ANGEL1 | | Sequence Position | 507-513 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Affinity purification | | Interaction ID | 22184 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23814182 | | Comments | The eIF4E binding YxxxxL motif found in human protein angel homolog 1 (ANGEL1) that mediates binding to the Eukaryotic translation initiation factor 4E (EIF4E) |
Record No : 128 |
| Instance ID | 12195 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | Q96B67 | | Bait Uniprot Identifier | ARRD3_HUMAN | | Bait Gene Name | ARRDC3 | | Sequence Position | 346-349 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography; ITC | | Interaction ID | 22195 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24379409 | | Comments | The PPXY motif (346-349) of human Arrestin domain-containing protein 3 (ARRDC3) that binds to the WW domains of human E3 ubiquitin-protein ligase NEDD4 |
Record No : 129 |
| Instance ID | 12196 | | Regular Expression | PPxY | | Motif Instance | PPLY | | Bait Uniprot Accession | Q96B67 | | Bait Uniprot Identifier | ARRD3_HUMAN | | Bait Gene Name | ARRDC3 | | Sequence Position | 391-394 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Sequence based prediction; ITC | | Interaction ID | 22196 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24379409 | | Comments | The PPXY motif (391-394) of human Arrestin domain-containing protein 3 (ARRDC3) that binds to the WW domains of human E3 ubiquitin-protein ligase NEDD4 |
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