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Total : 74 Records
Record No : 1 |
| Instance ID | 10009 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSRSAP | | Bait Uniprot Accession | O35147 | | Bait Uniprot Identifier | BAD_RAT | | Bait Gene Name | Bad | | Sequence Position | 134-139 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20009 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9369453 | | Comments | 14-3-3 binding motif in rat Bcl-xL/Bcl-2-associated death promoter that binds 14-3-3 protein zeta |
Record No : 2 |
| Instance ID | 10025 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RHSSYP | | Bait Uniprot Accession | Q61337 | | Bait Uniprot Identifier | BAD_MOUSE | | Bait Gene Name | Bad | | Sequence Position | 109-114 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20025 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8929531 | | Comments | Phosphorylation of death agonist BAD at Ser-112 in response to survival factor results in binding to 14-3-3 protein tau |
Record No : 3 |
| Instance ID | 10026 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSRSAP | | Bait Uniprot Accession | Q61337 | | Bait Uniprot Identifier | BAD_MOUSE | | Bait Gene Name | Bad | | Sequence Position | 133-138 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20026 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10949026, 8929531 | | Comments | Phosphorylation of the proapoptotic Bcl-2 family member BAD at Ser-136 recruits 14-3-3 protein zeta that then function to increase the accessibility of Ser-155 to survival-promoting kinases |
Record No : 4 |
| Instance ID | 10162 | | Regular Expression | xKENx | | Motif Instance | NKENY | | Bait Uniprot Accession | O43683 | | Bait Uniprot Identifier | BUB1_HUMAN | | Bait Gene Name | BUB1 | | Sequence Position | 534-538 | | Critical Residues | P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Ubiquitinase assay | | Interaction ID | 20162 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17158872 | | Comments | First KEN-box motif (534-538) identified in the central region of human Bub1 that is the major degron involved in the degradation of Bub1 by the APC/C coactivator Cdh1 |
Record No : 5 |
| Instance ID | 10163 | | Regular Expression | xKENx | | Motif Instance | DKENV | | Bait Uniprot Accession | O43683 | | Bait Uniprot Identifier | BUB1_HUMAN | | Bait Gene Name | BUB1 | | Sequence Position | 624-628 | | Critical Residues | P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Ubiquitinase assay | | Interaction ID | 20163 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17158872 | | Comments | Second KEN-box motif (624-628) identified in the central region of human Bub1 that is involved in the degradation of Bub1 by the APC/C coactivator Cdh1 |
Record No : 6 |
| Instance ID | 10173 | | Regular Expression | xKENx | | Motif Instance | AKENE | | Bait Uniprot Accession | O60566 | | Bait Uniprot Identifier | BUB1B_HUMAN | | Bait Gene Name | BUB1B | | Sequence Position | 303-307 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20173 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22193957 | | Comments | Second KEN-box motif (303-307) of human Mitotic checkpoint kinase BUB1 beta, a subunit of the Spindle Assembly Checkpoint (SAC),that binds to the substrate recruitment site of human CDC20, the substrate recognition subunit of the Anaphase Promoting Complex/Cyclosome (APC/C), thereby blocking the recruitment of substrates to the APC/C |
Record No : 7 |
| Instance ID | 10174 | | Regular Expression | xKENx | | Motif Instance | SKENV | | Bait Uniprot Accession | O60566 | | Bait Uniprot Identifier | BUB1B_HUMAN | | Bait Gene Name | BUB1B | | Sequence Position | 25-29 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | 3(10)-helix | | Experimental Method(s) | X-ray crystallography; Mutation analysis | | Interaction ID | 20174 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23091007 | | Comments | Checkpoint inhibition of APC/C(Cdc20) requires the binding of the first BubR1 (BUB1B) KEN box (25-29) to Cdc20 |
Record No : 8 |
| Instance ID | 10212 | | Regular Expression | x(S)xxF | | Motif Instance | TSPTF | | Bait Uniprot Accession | Q9BX63 | | Bait Uniprot Identifier | FANCJ_HUMAN | | Bait Gene Name | BRIP1 | | Sequence Position | 989-993 | | Critical Residues | P2; P3; P5 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Pull down; Mutation analysis | | Interaction ID | 20212 | | Interacting Domain | BRCT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15133502, 14576433 | | Comments | Phosphorylated serine (pS) sequence (989-993) in human BRCA1-Associated Carboxyl-terminal Helicase (BACH1) that mediates specific interaction with the carboxyl-terminal domain (BRCT) of the Breast Cancer Gene 1 (BRCA1) protein, which is cell cycle regulated and is required for DNA damage–induced checkpoint control during the transition from G2 to M phase of the cell cycle |
Record No : 9 |
| Instance ID | 10217 | | Regular Expression | x(S)xxFxK | | Motif Instance | TSPTFNK | | Bait Uniprot Accession | Q9BX63 | | Bait Uniprot Identifier | FANCJ_HUMAN | | Bait Gene Name | BRIP1 | | Sequence Position | 989-995 | | Critical Residues | P2 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Mutation analysis; Pull down; SPR; ITC | | Interaction ID | 20217 | | Interacting Domain | BRCT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15125843, 14576433 | | Comments | Phosphorylated serine (pS) sequence (989-995) in human BRCA1-Associated Carboxyl-terminal Helicase (BACH1) that mediates specific interaction with the carboxyl-terminal domain (BRCT) of the Breast Cancer Gene 1 (BRCA1) protein, which is cell cycle regulated and is required for DNA damage–induced checkpoint control during the transition from G2 to M phase of the cell cycle |
Record No : 10 |
| Instance ID | 10231 | | Regular Expression | L[IVLMF]x[IVLMF][DE] | | Motif Instance | LLDLD | | Bait Uniprot Accession | O00499 | | Bait Uniprot Identifier | BIN1_HUMAN | | Bait Gene Name | BIN1 | | Sequence Position | 390-394 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Pull down; Western blot | | Interaction ID | 20231 | | Interacting Domain | Clathrin propeller repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9603201 | | Comments | Clathrin box motif in human Amphiphysin II (BIN1) that is sufficient for binding to the amino terminal beta propeller structure of Clathrin heavy chain |
Record No : 11 |
| Instance ID | 10240 | | Regular Expression | x[NP]W[DES]xW | | Motif Instance | IPWDLW | | Bait Uniprot Accession | O00499 | | Bait Uniprot Identifier | BIN1_HUMAN | | Bait Gene Name | BIN1 | | Sequence Position | 415-420 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Western blot; Pull down | | Interaction ID | 20240 | | Interacting Domain | Clathrin propeller repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9603201 | | Comments | "Variant clathrin box motif (W box) in human Amphiphysin II (BIN1) that are found in tandem arrangement with a ""classical"" clathrin box and cooperate to effect optimal clathrin binding and the formation of sedimentable assemblies" |
Record No : 12 |
| Instance ID | 10306 | | Regular Expression | [^P]x[KR]xTQT | | Motif Instance | CDKSTQT | | Bait Uniprot Accession | O43521 | | Bait Uniprot Identifier | B2L11_HUMAN | | Bait Gene Name | BCL2L11 | | Sequence Position | 110-116 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Y2H; Overlapping binding peptide; Pull down | | Interaction ID | 20306 | | Interacting Domain | Dynein light chain type 1 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11178896, 11148209 | | Comments | Dynein (Light Chain) binding KxTQT motif in human Bcl-2-like protein 11 (BCL2L11)/ Bcl2-interacting mediator of cell death (BIM) that binds to DLC-8 |
Record No : 13 |
| Instance ID | 10310 | | Regular Expression | [^P]x[KR]xTQT | | Motif Instance | CDKSTQT | | Bait Uniprot Accession | O43521 | | Bait Uniprot Identifier | B2L11_HUMAN | | Bait Gene Name | BCL2L11 | | Sequence Position | 50-56 | | Critical Residues | P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Co-IP; Mutation analysis | | Interaction ID | 20310 | | Interacting Domain | Dynein light chain type 1 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10198631, 12591950 | | Comments | Dynein (Light Chain) binding KxTQT motif in Isoform Bim(L) of human Bcl-2-like protein 11 (BCL2L11)/ Bcl2-interacting mediator of cell death (BIM) that binds to DLC-8 to neutralize its antiapoptotic activity |
Record No : 14 |
| Instance ID | 10404 | | Regular Expression | x[FYH]x[IVM][^WFYP][^WFYP][ILM][ILMV]x | | Motif Instance | GFSIEDIMR | | Bait Uniprot Accession | Q9VQU9 | | Bait Uniprot Identifier | BOWEL_DROME | | Bait Gene Name | bowl | | Sequence Position | 735-743 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20404 | | Interacting Domain | WD domain, G-beta repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16314497 | | Comments | The eh1 motif in Drosophila Protein Brother of odd with entrails limited (bowl) that binds to the WD40 domain of the Groucho corepressor |
Record No : 15 |
| Instance ID | 10628 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | LFSTEV | | Bait Uniprot Accession | P11274 | | Bait Uniprot Identifier | BCR_HUMAN | | Bait Gene Name | BCR | | Sequence Position | 1266-1271 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | NMR | | Interaction ID | 20628 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17473018 | | Comments | The PDZ domain of human AF-6/MLLT4 binds to the C-terminal PDZ domain-binding motif of human Breakpoint cluster region protein (BCR) efficiently after phosphorylation of AF-6 by the BCR kinase |
Record No : 16 |
| Instance ID | 10667 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | TLVSTV | | Bait Uniprot Accession | Q9UQB8 | | Bait Uniprot Identifier | BAIP2_HUMAN | | Bait Gene Name | BAIAP2 | | Sequence Position | 516-521 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Affinity chromatography technology; Peptide binding to perpetrator; Co-IP; Colocalization | | Interaction ID | 20667 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15255944 | | Comments | Class 1 PDZ domain-binding motif in Isoform BAIAP2-alpha of human Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2)/ Insulin receptor substrate p53 (IRSp53) that mediates binding to the PDZ domain of human SHANK1 |
Record No : 17 |
| Instance ID | 10668 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | TLVSTV | | Bait Uniprot Accession | Q9UQB8 | | Bait Uniprot Identifier | BAIP2_HUMAN | | Bait Gene Name | BAIAP2 | | Sequence Position | 516-521 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Affinity chromatography technology; Peptide binding to perpetrator; Co-IP; Colocalization | | Interaction ID | 20668 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15255944 | | Comments | Class 1 PDZ domain-binding motif in Isoform BAIAP2-alpha of human Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2)/ Insulin receptor substrate p53 (IRSp53) that mediates binding to the PDZ domain of human DLG4/PSD-95/SAP-90 |
Record No : 18 |
| Instance ID | 10705 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | SPKVTFE | | Bait Uniprot Accession | P38398 | | Bait Uniprot Identifier | BRCA1_HUMAN | | Bait Gene Name | BRCA1 | | Sequence Position | 896-902 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Co-IP; Pull down; Mutation analysis; Western blot | | Interaction ID | 20705 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17603999 | | Comments | The catalytic subunit of human protein phosphatase 1 (PPP1CA) interacts with and dephosphorylates human Breast cancer type 1 susceptibility protein (BRCA1) through the RVXF motif of BRCA1 and may thus serve as a general regulator for BRCA1 phosphorylation |
Record No : 19 |
| Instance ID | 10839 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGYNT | | Bait Uniprot Accession | Q6PGQ7 | | Bait Uniprot Identifier | BORA_HUMAN | | Bait Gene Name | BORA | | Sequence Position | 496-501 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Thr-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Mass spectrometry; Protein kinase assay; Co-IP | | Interaction ID | 20839 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18378770 | | Comments | The DSGxxS phospho-dependent degron in Human aurora borealis (BORA) that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC), a component of the SCF ubiquitin ligase complex leading to BORA degradation, which is required for normal mitotic progression |
Record No : 20 |
| Instance ID | 10875 | | Regular Expression | [RKY]xxPxxP | | Motif Instance | KPLPPTP | | Bait Uniprot Accession | Q06187 | | Bait Uniprot Identifier | BTK_HUMAN | | Bait Gene Name | BTK | | Sequence Position | 186-192 | | Critical Residues | P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Alanine scanning; GPC; NMR | | Interaction ID | 20875 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11707259 | | Comments | Proline-rich SH3-binding sequence (186-192) in the TH region of Bruton tyrosine kinase (BTK) that stabilize intermolecular self-association with the SH3 domain of another BTK molecule |
Record No : 21 |
| Instance ID | 10876 | | Regular Expression | [RKY]xxPxxP | | Motif Instance | KPLPPEP | | Bait Uniprot Accession | Q06187 | | Bait Uniprot Identifier | BTK_HUMAN | | Bait Gene Name | BTK | | Sequence Position | 200-206 | | Critical Residues | P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Alanine scanning; GPC; NMR | | Interaction ID | 20876 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11707259 | | Comments | Proline-rich SH3-binding sequence (200-206) in the TH region of Bruton tyrosine kinase (BTK) that stabilize intermolecular self-association with the SH3 domain of another BTK molecule |
Record No : 22 |
| Instance ID | 10910 | | Regular Expression | xxx[PV]xxP | | Motif Instance | PPVPPPP | | Bait Uniprot Accession | O00499 | | Bait Uniprot Identifier | BIN1_HUMAN | | Bait Gene Name | BIN1 | | Sequence Position | 308-314 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Classical fluorescence spectroscopy; Peptide binding to perpetrator; Y2H; NMR; Competition binding; Mutation analysis | | Interaction ID | 20910 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15992821 | | Comments | Tumor-specific isoforms of human BIN1 are precluded from interaction with c-Myc through an intramolecular polyproline-SH3 domain interaction that inhibits the BIN1 SH3 domain from binding to c-Myc |
Record No : 23 |
| Instance ID | 10995 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | SRSEGEGE | | Bait Uniprot Accession | Q9NWV8 | | Bait Uniprot Identifier | BABA1_HUMAN | | Bait Gene Name | BABAM1 | | Sequence Position | 47-54 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence polarization spectroscopy; Mutation analysis; Co-IP | | Interaction ID | 20995 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22153077 | | Comments | The N-terminal region of ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif (47-54) in human MERIT40/BABAM1 |
Record No : 24 |
| Instance ID | 10999 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | ARPDGEGS | | Bait Uniprot Accession | A9UF02 | | Bait Uniprot Identifier | A9UF02_HUMAN | | Bait Gene Name | BCR/ABL fusion | | Sequence Position | 115-122 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence polarization spectroscopy; Mutation analysis; Co-IP | | Interaction ID | 20999 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22153077 | | Comments | The N-terminal region of ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif in human BCR/ABL fusion protein isoform X9 |
Record No : 25 |
| Instance ID | 11001 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | TRSNPEGA | | Bait Uniprot Accession | Q9NWV8 | | Bait Uniprot Identifier | BABA1_HUMAN | | Bait Gene Name | BABAM1 | | Sequence Position | 27-34 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence polarization spectroscopy; Mutation analysis; Co-IP | | Interaction ID | 21001 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22153077 | | Comments | The N-terminal region of ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif (27-34) in human MERIT40/BABAM1 |
Record No : 26 |
| Instance ID | 11120 | | Regular Expression | xxx([ST])Px | | Motif Instance | KKTSPL | | Bait Uniprot Accession | P35991 | | Bait Uniprot Identifier | BTK_MOUSE | | Bait Gene Name | Btk | | Sequence Position | 18-23 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Alanine scanning | | Interaction ID | 21120 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16644721 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the Ser-21-Pro motif of mouse Tyrosine-protein kinase Btk in a cell cycle-dependent manner, thereby regulating the Btk expression level |
Record No : 27 |
| Instance ID | 11121 | | Regular Expression | xxx([ST])Px | | Motif Instance | YVFSPT | | Bait Uniprot Accession | P35991 | | Bait Uniprot Identifier | BTK_MOUSE | | Bait Gene Name | Btk | | Sequence Position | 112-117 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Alanine scanning | | Interaction ID | 21121 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16644721 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the Ser-115-Pro motif of mouse Tyrosine-protein kinase Btk in a cell cycle-dependent manner, thereby regulating the Btk expression level |
Record No : 28 |
| Instance ID | 11146 | | Regular Expression | xxx([ST])Px | | Motif Instance | GRSSPS | | Bait Uniprot Accession | P78543 | | Bait Uniprot Identifier | BTG2_HUMAN | | Bait Gene Name | BTG2 | | Sequence Position | 144-149 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Mutation analysis | | Interaction ID | 21146 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15788397 | | Comments | Phosphorylation of serine 147 of human NGF-inducible anti-proliferative protein PC3/BTG2 induces binding to human Peptidyl-prolyl cis-trans isomerase PIN1 in cytoplasm and cell death |
Record No : 29 |
| Instance ID | 11176 | | Regular Expression | [EN][FYLW][NSQ]xEE[ILMVF][^P][LIVMFA] | | Motif Instance | EFNTEEILA | | Bait Uniprot Accession | P41695 | | Bait Uniprot Identifier | BUB1_YEAST | | Bait Gene Name | BUB1 | | Sequence Position | 333-341 | | Critical Residues | P1; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | ITC; X-ray crystallography | | Interaction ID | 21176 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17227844 | | Comments | The Gle2-binding-sequence (GLEBS) motif found in yeast Checkpoint serine/threonine-protein kinase BUB1 binds to the WD40 domain of yeast Cell cycle arrest protein BUB3 |
Record No : 30 |
| Instance ID | 11177 | | Regular Expression | [EN][FYLW][NSQ]xEE[ILMVF][^P][LIVMFA] | | Motif Instance | EFSFEELRA | | Bait Uniprot Accession | O43683 | | Bait Uniprot Identifier | BUB1_HUMAN | | Bait Gene Name | BUB1 | | Sequence Position | 248-256 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 21177 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11352911 | | Comments | The Gle2-binding-sequence (GLEBS) motif found in human Mitotic checkpoint serine/threonine-protein kinase BUB1 binds to the WD40 domain of human Mitotic checkpoint protein BUB3 |
Record No : 31 |
| Instance ID | 11259 | | Regular Expression | [KR]xTQTx | | Motif Instance | KSTQTP | | Bait Uniprot Accession | O43521 | | Bait Uniprot Identifier | B2L11_HUMAN | | Bait Gene Name | BCL2L11 | | Sequence Position | 111-117 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Mutational analysis; Y2H | | Interaction ID | 21259 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10198631, 11178896, 14561217 | | Comments | The proapoptotic activity of the human Bcl-2 family member BIM (BCL2L11) is regulated by interaction with the 8 kDa Dynein light chain 1 (DYNLL1/DLC8) through a conserved (K/R)XTQT consensus sequence |
Record No : 32 |
| Instance ID | 11260 | | Regular Expression | [KR]xTQTx | | Motif Instance | KATQTL | | Bait Uniprot Accession | Q96LC9 | | Bait Uniprot Identifier | BMF_HUMAN | | Bait Gene Name | BMF | | Sequence Position | 68-73 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; ITC | | Interaction ID | 21260 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14561217, 20889982 | | Comments | The KXTQTX motif in human Bcl-2-modifying factor (BMF) that interacts with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8) |
Record No : 33 |
| Instance ID | 11261 | | Regular Expression | [KR]xTQTx | | Motif Instance | KATQTL | | Bait Uniprot Accession | Q96LC9 | | Bait Uniprot Identifier | BMF_HUMAN | | Bait Gene Name | BMF | | Sequence Position | 68-73 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Site-directed mutagenesis; ITC; SPR; Fluorescence anisotropy; Stopped-flow fluorescence spectroscopy | | Interaction ID | 21261 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14561217, 20889982, 11546872 | | Comments | The KXTQTX motif in human Bcl-2-modifying factor (BMF) that interacts with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2) |
Record No : 34 |
| Instance ID | 11299 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | NYGSQTE | | Bait Uniprot Accession | O88778 | | Bait Uniprot Identifier | BSN_RAT | | Bait Gene Name | Bsn | | Sequence Position | 1420-1426 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; SPR | | Interaction ID | 21299 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19380881, 21533121 | | Comments | The LC8 dynein light chain binding motif (1420-1426) in rat protein bassoon (Bsn) that binds to the rat 8 kDa Dynein light chain 1 (Dynll1) |
Record No : 35 |
| Instance ID | 11300 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | EFSTQTP | | Bait Uniprot Accession | O88778 | | Bait Uniprot Identifier | BSN_RAT | | Bait Gene Name | Bsn | | Sequence Position | 1496-1502 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; SPR | | Interaction ID | 21300 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19380881, 21533121 | | Comments | The LC8 dynein light chain binding motif (1496-1502) in rat protein bassoon (Bsn) that binds to the rat 8 kDa Dynein light chain 1 (Dynll1) |
Record No : 36 |
| Instance ID | 11301 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | AQGTQTP | | Bait Uniprot Accession | O88778 | | Bait Uniprot Identifier | BSN_RAT | | Bait Gene Name | Bsn | | Sequence Position | 1522-1528 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; SPR | | Interaction ID | 21301 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19380881, 21533121 | | Comments | The LC8 dynein light chain binding motif (1522-1528) in rat protein bassoon (Bsn) that binds to the rat 8 kDa Dynein light chain 1 (Dynll1) |
Record No : 37 |
| Instance ID | 11302 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | NYGSQTE | | Bait Uniprot Accession | O88778 | | Bait Uniprot Identifier | BSN_RAT | | Bait Gene Name | Bsn | | Sequence Position | 1420-1426 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; SPR | | Interaction ID | 21302 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19380881, 21533121 | | Comments | The LC8 dynein light chain binding motif (1420-1426) in rat protein bassoon (Bsn) that binds to the rat Dynein light chain LC8-type 2 (Dynll2) |
Record No : 38 |
| Instance ID | 11303 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | EFSTQTP | | Bait Uniprot Accession | O88778 | | Bait Uniprot Identifier | BSN_RAT | | Bait Gene Name | Bsn | | Sequence Position | 1496-1502 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; SPR | | Interaction ID | 21303 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19380881, 21533121 | | Comments | The LC8 dynein light chain binding motif (1496-1502) in rat protein bassoon (Bsn) that binds to the rat Dynein light chain LC8-type 2 (Dynll2) |
Record No : 39 |
| Instance ID | 11304 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | AQGTQTP | | Bait Uniprot Accession | O88778 | | Bait Uniprot Identifier | BSN_RAT | | Bait Gene Name | Bsn | | Sequence Position | 1522-1528 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; SPR | | Interaction ID | 21304 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19380881, 21533121 | | Comments | The LC8 dynein light chain binding motif (1522-1528) in rat protein bassoon (Bsn) that binds to the rat Dynein light chain LC8-type 2 (Dynll2) |
Record No : 40 |
| Instance ID | 11306 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | DAQVQTD | | Bait Uniprot Accession | O75363 | | Bait Uniprot Identifier | BCAS1_HUMAN | | Bait Gene Name | BCAS1 | | Sequence Position | 567-573 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21306 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in human Breast carcinoma-amplified sequence 1 (BCAS1) that interacts with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8) |
Record No : 41 |
| Instance ID | 11307 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | DAQVQTD | | Bait Uniprot Accession | O75363 | | Bait Uniprot Identifier | BCAS1_HUMAN | | Bait Gene Name | BCAS1 | | Sequence Position | 567-573 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21307 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in human Breast carcinoma-amplified sequence 1 (BCAS1) that interacts with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2) |
Record No : 42 |
| Instance ID | 11340 | | Regular Expression | SxxF | | Motif Instance | SPTF | | Bait Uniprot Accession | Q9BX63 | | Bait Uniprot Identifier | FANCJ_HUMAN | | Bait Gene Name | BRIP1 | | Sequence Position | 990-993 | | Critical Residues | P1; P4 | | Motif PTM(s) | Phosphorylation at Ser-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; NMR; Site-directed Mutagenesis; SPR; ITC | | Interaction ID | 21340 | | Interacting Domain | BRCT domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15133503, 15133502, 15242590, 14576433 | | Comments | Motif mediating phosphorylation-dependent BRCA1-BACH1 interaction essential for G2 accumulation checkpoint control of the cell cycle |
Record No : 43 |
| Instance ID | 11343 | | Regular Expression | SxxF | | Motif Instance | SPVF | | Bait Uniprot Accession | Q6PJG6 | | Bait Uniprot Identifier | BRAT1_HUMAN | | Bait Gene Name | BRAT1 | | Sequence Position | 269-272 | | Critical Residues | P1; P4 | | Motif PTM(s) | Phosphorylation at Ser-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; ITC | | Interaction ID | 21343 | | Interacting Domain | BRCT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14578343, 24073851, 16452482 | | Comments | Motif required for BRCA1-BRAT1 interaction involved in DNA damage-induced ATM activation |
Record No : 44 |
| Instance ID | 11466 | | Regular Expression | [RK]Sx[ST]xP | | Motif Instance | RSSSAP | | Bait Uniprot Accession | P15056 | | Bait Uniprot Identifier | BRAF_HUMAN | | Bait Gene Name | BRAF | | Sequence Position | 362-367 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21466 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8601312 | | Comments | 14-3-3 binding motif in BRAF (pS-365) which binds 14-3-3 protein zeta |
Record No : 45 |
| Instance ID | 11467 | | Regular Expression | [RK]Sx[ST]xP | | Motif Instance | RSASEP | | Bait Uniprot Accession | P15056 | | Bait Uniprot Identifier | BRAF_HUMAN | | Bait Gene Name | BRAF | | Sequence Position | 726-731 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21467 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8601312 | | Comments | 14-3-3 binding motif in BRAF (pS-729) which binds 14-3-3 protein zeta |
Record No : 46 |
| Instance ID | 11669 | | Regular Expression | FxFP | | Motif Instance | FGFP | | Bait Uniprot Accession | P53004 | | Bait Uniprot Identifier | BIEA_HUMAN | | Bait Gene Name | BLVRA | | Sequence Position | 162-165 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21669 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18463290 | | Comments | FXFP or C-box sequence in the human Biliverdin reductase A (BLVRA) that provides the specific binding and substrate recognition site for Mitogen-activated protein kinase 3 (MAPK3) [or ERK1] |
Record No : 47 |
| Instance ID | 11670 | | Regular Expression | FxFP | | Motif Instance | FGFP | | Bait Uniprot Accession | P53004 | | Bait Uniprot Identifier | BIEA_HUMAN | | Bait Gene Name | BLVRA | | Sequence Position | 162-165 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21670 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18463290 | | Comments | FXFP or C-box sequence in the human Biliverdin reductase A (BLVRA) that provides the specific binding and substrate recognition site for Mitogen-activated protein kinase 1 (MAPK1) [or ERK2] |
Record No : 48 |
| Instance ID | 11671 | | Regular Expression | [KR][KR][KR]x{1,5}[LI]x[LI] | | Motif Instance | KKRILHCLGL | | Bait Uniprot Accession | P53004 | | Bait Uniprot Identifier | BIEA_HUMAN | | Bait Gene Name | BLVRA | | Sequence Position | 275-284 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21671 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18463290 | | Comments | D-box sequence in the human Biliverdin reductase A (BLVRA) that provides the specific binding and substrate recognition site for Mitogen-activated protein kinase 3 (MAPK3) [or ERK1] |
Record No : 49 |
| Instance ID | 11672 | | Regular Expression | [KR][KR][KR]x{1,5}[LI]x[LI] | | Motif Instance | KKRILHCLGL | | Bait Uniprot Accession | P53004 | | Bait Uniprot Identifier | BIEA_HUMAN | | Bait Gene Name | BLVRA | | Sequence Position | 275-284 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21672 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18463290 | | Comments | D-box sequence in the human Biliverdin reductase A (BLVRA) that provides the specific binding and substrate recognition site for Mitogen-activated protein kinase 1 (MAPK1) [or ERK2] |
Record No : 50 |
| Instance ID | 11673 | | Regular Expression | KKRILHC | | Motif Instance | KKRILHC | | Bait Uniprot Accession | P53004 | | Bait Uniprot Identifier | BIEA_HUMAN | | Bait Gene Name | BLVRA | | Sequence Position | 275-281 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutational analysis; Pull down(GST tag); Competition binding assay | | Interaction ID | 21673 | | Interacting Domain | Unknown | | Disease Association(s) | Goodpasture syndrome (GPS) | | Inhibitor(s) | Unknown | | Reference(s) | 20177069 | | Comments | The human Biliverdin reductase A (BLVRA) D-Box core sequence that interacts with and inhibits Goodpasture antigen-binding protein (COL4A3BP) from interaction with the docking protein(s) required for its translocation to the cell membrane and points of assembly for signaling molecules that include upstream kinases |
Record No : 51 |
| Instance ID | 11674 | | Regular Expression | KRNRYLS | | Motif Instance | KRNRYLS | | Bait Uniprot Accession | P53004 | | Bait Uniprot Identifier | BIEA_HUMAN | | Bait Gene Name | BLVRA | | Sequence Position | 224-230 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Protein kinase assay | | Interaction ID | 21674 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17639074 | | Comments | The human Biliverdin reductase A (BLVRA) peptide that blocks Protein kinase C zeta docking site interaction |
Record No : 52 |
| Instance ID | 11675 | | Regular Expression | KKRILHC | | Motif Instance | KKRILHC | | Bait Uniprot Accession | P53004 | | Bait Uniprot Identifier | BIEA_HUMAN | | Bait Gene Name | BLVRA | | Sequence Position | 275-281 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutational analysis; Protein kinase assay | | Interaction ID | 21675 | | Interacting Domain | C1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17639074 | | Comments | The human Biliverdin reductase A (BLVRA) peptide that disrupts function of the Protein kinase C zeta C1 domain |
Record No : 53 |
| Instance ID | 11676 | | Regular Expression | KYCCSRK | | Motif Instance | KYCCSRK | | Bait Uniprot Accession | P53004 | | Bait Uniprot Identifier | BIEA_HUMAN | | Bait Gene Name | BLVRA | | Sequence Position | 290-296 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutational analysis; Protein kinase assay | | Interaction ID | 21676 | | Interacting Domain | ATP-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17639074 | | Comments | The human Biliverdin reductase A (BLVRA) peptide that alters ATP presentation to the Protein kinase C zeta |
Record No : 54 |
| Instance ID | 11781 | | Regular Expression | PxPxPR | | Motif Instance | PSPLPR | | Bait Uniprot Accession | Q8WV28 | | Bait Uniprot Identifier | BLNK_HUMAN | | Bait Gene Name | BLNK | | Sequence Position | 242-247 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21781 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286 | | Comments | A novel polyproline-arginine motif (PXXXPR) [242-247] in human B-cell linker protein that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA) |
Record No : 55 |
| Instance ID | 11782 | | Regular Expression | PxPxPR | | Motif Instance | PIPLPR | | Bait Uniprot Accession | Q8WV28 | | Bait Uniprot Identifier | BLNK_HUMAN | | Bait Gene Name | BLNK | | Sequence Position | 307-312 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21782 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286 | | Comments | A novel polyproline-arginine motif (PXXXPR) [307-312] in human B-cell linker protein that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA) |
Record No : 56 |
| Instance ID | 11783 | | Regular Expression | PxPxPR | | Motif Instance | PSPLPR | | Bait Uniprot Accession | Q9QUN3 | | Bait Uniprot Identifier | BLNK_MOUSE | | Bait Gene Name | Blnk | | Sequence Position | 243-248 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21783 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286 | | Comments | A novel polyproline-arginine motif (PXXXPR) [243-248] in mouse B-cell linker protein that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA) |
Record No : 57 |
| Instance ID | 11784 | | Regular Expression | PxPxPR | | Motif Instance | PVPLPR | | Bait Uniprot Accession | Q9QUN3 | | Bait Uniprot Identifier | BLNK_MOUSE | | Bait Gene Name | Blnk | | Sequence Position | 308-313 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21784 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286 | | Comments | A novel polyproline-arginine motif (PXXXPR) [308-313] in mouse B-cell linker protein that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA) |
Record No : 58 |
| Instance ID | 11806 | | Regular Expression | [RK]x{0,1}[VIL][^P][FW] | | Motif Instance | RVQF | | Bait Uniprot Accession | Q962F2 | | Bait Uniprot Identifier | Q962F2_DROME | | Bait Gene Name | bif | | Sequence Position | 993-996 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Competition binding assay | | Interaction ID | 21806 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11238949 | | Comments | The consensus PP1-binding motif of Drosophila Protein phosphatase 1-binding protein Bifocal that is essential for its interaction with the major form of D. melanogaster PP1 encoded at locus 87B (Pp1-87B) |
Record No : 59 |
| Instance ID | 11807 | | Regular Expression | [RK]x{0,1}[VIL][^P][FW] | | Motif Instance | RVQF | | Bait Uniprot Accession | Q962F2 | | Bait Uniprot Identifier | Q962F2_DROME | | Bait Gene Name | bif | | Sequence Position | 993-996 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21807 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11238949 | | Comments | The consensus PP1-binding motif of Drosophila Protein phosphatase 1-binding protein Bifocal that could bind the human PP1-gamma catalytic subunit |
Record No : 60 |
| Instance ID | 11825 | | Regular Expression | R[ST][ST]SL | | Motif Instance | RSTSL | | Bait Uniprot Accession | P40450 | | Bait Uniprot Identifier | BNR1_YEAST | | Bait Gene Name | BNR1 | | Sequence Position | 645-649 | | Critical Residues | P1; P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Mutational analysis | | Interaction ID | 21825 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18280496 | | Comments | The consensus R[ST][ST]SL motif in Bnr1p of Saccharomyces cerevisiae (strain ATCC 204508 / S288c) that is necessary, but not sufficient for binding to the Fus1p SH3 domain |
Record No : 61 |
| Instance ID | 11830 | | Regular Expression | R[ST][ST]SL | | Motif Instance | RSTSL | | Bait Uniprot Accession | C7GUS5 | | Bait Uniprot Identifier | C7GUS5_YEAS2 | | Bait Gene Name | BNR1 | | Sequence Position | 645-649 | | Critical Residues | P1; P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Mutational analysis | | Interaction ID | 21830 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18280496 | | Comments | The consensus R[ST][ST]SL motif in Bnr1p of Saccharomyces cerevisiae (strain JAY291) that is necessary, but not sufficient for binding to the Fus1p SH3 domain |
Record No : 62 |
| Instance ID | 11967 | | Regular Expression | PxxxRxxKP | | Motif Instance | PMVNRSTKP | | Bait Uniprot Accession | Q9QUN3 | | Bait Uniprot Identifier | BLNK_MOUSE | | Bait Gene Name | Blnk | | Sequence Position | 204-212 | | Critical Residues | P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPOT Analysis | | Interaction ID | 21967 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12176364 | | Comments | The high-affinity atypical R-X-X-K binding motif in mouse B-cell linker protein for binding the Gads SH3 Domain |
Record No : 63 |
| Instance ID | 12032 | | Regular Expression | LxLxL | | Motif Instance | LELTL | | Bait Uniprot Accession | Q8S307 | | Bait Uniprot Identifier | BZR1_ARATH | | Bait Gene Name | BZR1 | | Sequence Position | 325-329 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Co-IP | | Interaction ID | 22032 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24938363 | | Comments | The Arabidopsis thaliana transcription factor BRASSINAZOLE-RESISTANT 1 (BZR1) interacts with the transcriptional corepressor TOPLESS (TPL) through the conserved ERF-associated amphiphilic repression (EAR) motif at the carboxy terminus of BZR1 whose deletion or mutation abolishes the ability of BZR1 to regulate gene expression and cell elongation |
Record No : 64 |
| Instance ID | 12155 | | Regular Expression | [ILVFYM]xxx[ILVFYM][KR]xx[GAS][DE]x[ILVFYM] | | Motif Instance | LSRRLKVTGDLF | | Bait Uniprot Accession | Q14457 | | Bait Uniprot Identifier | BECN1_HUMAN | | Bait Gene Name | BECN1 | | Sequence Position | 112-123 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; NMR | | Interaction ID | 22155 | | Interacting Domain | Bcl-XL Delta-loop | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24115198 | | Comments | The conserved sequence motif in the C-terminal half of the intrinsically disordered BCL2 homology 3 domain of human Beclin-1 (BECN1) that adopts an alpha-helical conformation upon binding to human Bcl-2-like protein 1 (BCL2L1) |
Record No : 65 |
| Instance ID | 12156 | | Regular Expression | [GD]DIWK | | Motif Instance | GDIWK | | Bait Uniprot Accession | G0WVJ8 | | Bait Uniprot Identifier | G0WVJ8_MACMU | | Bait Gene Name | BST2 | | Sequence Position | 14-18 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 22156 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24109238, 19436700 | | Comments | The (G/D)DIWK motif in the cytoplasmic domain of Bone marrow stromal cell antigen 2 (BST2) of Macaca mulatta (Rhesus macaque) that represents the cytoplasmic component responsible for the interaction with HIV-1 VPU protein |
Record No : 66 |
| Instance ID | 12157 | | Regular Expression | [GD]DIWK | | Motif Instance | DDIWK | | Bait Uniprot Accession | D7RVC2 | | Bait Uniprot Identifier | D7RVC2_PANTR | | Bait Gene Name | BST2 | | Sequence Position | 14-18 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 22157 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24109238, 19436700 | | Comments | The (G/D)DIWK motif in the cytoplasmic domain of Bone marrow stromal cell antigen 2 (BST2) of Pan troglodytes (Chimpanzee) that represents the cytoplasmic component responsible for the interaction with HIV-1 VPU protein |
Record No : 67 |
| Instance ID | 12158 | | Regular Expression | [GD]DIWK | | Motif Instance | GDIWK | | Bait Uniprot Accession | G0WVJ8 | | Bait Uniprot Identifier | G0WVJ8_MACMU | | Bait Gene Name | BST2 | | Sequence Position | 14-18 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 22158 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19436700 | | Comments | The (G/D)DIWK motif in the cytoplasmic domain of Bone marrow stromal cell antigen 2 (BST2) of Macaca mulatta (Rhesus macaque) that represents the cytoplasmic component responsible for the interaction with the Nef protein of Simian immunodeficiency virus (isolate mac239) |
Record No : 68 |
| Instance ID | 12171 | | Regular Expression | x(S)xxF | | Motif Instance | RSPVF | | Bait Uniprot Accession | Q6PJG6 | | Bait Uniprot Identifier | BRAT1_HUMAN | | Bait Gene Name | BRAT1 | | Sequence Position | 268-272 | | Critical Residues | P2; P3; P4; P5 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; X-ray crystallography | | Interaction ID | 22171 | | Interacting Domain | BRCT domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 24073851 | | Comments | Phosphorylated serine (pS) sequence in human BRCA1-associated ATM activator 1 (BRAT1/BAAT1) that mediates a direct physical interaction with the carboxyl-terminal domain (BRCT) of the human Breast Cancer Gene 1 (BRCA1) protein |
Record No : 69 |
| Instance ID | 12185 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | DLQTEV | | Bait Uniprot Accession | O14514 | | Bait Uniprot Identifier | BAI1_HUMAN | | Bait Gene Name | BAI1 | | Sequence Position | 1579-1584 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | PDZ Domain Proteomic Array | | Interaction ID | 22185 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23782696 | | Comments | C-terminal class 1 PDZ-binding motif in human Brain-specific angiogenesis inhibitor 1 (BAI1) that binds to the PDZ1 and PDZ2 domains of human Disks large homolog 4 (DLG4/PSD95) |
Record No : 70 |
| Instance ID | 12186 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | DLQTEV | | Bait Uniprot Accession | O14514 | | Bait Uniprot Identifier | BAI1_HUMAN | | Bait Gene Name | BAI1 | | Sequence Position | 1579-1584 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | PDZ Domain Proteomic Array | | Interaction ID | 22186 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23782696 | | Comments | C-terminal class 1 PDZ-binding motif in human Brain-specific angiogenesis inhibitor 1 (BAI1) that binds to the PDZ4 and PDZ5 domains of human Membrane-associated guanylate kinase inverted 1 (MAGI-1) |
Record No : 71 |
| Instance ID | 12187 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | DLQTEV | | Bait Uniprot Accession | O14514 | | Bait Uniprot Identifier | BAI1_HUMAN | | Bait Gene Name | BAI1 | | Sequence Position | 1579-1584 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Pull down(GST tag); PDZ Domain Proteomic Array | | Interaction ID | 22187 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23782696 | | Comments | C-terminal class 1 PDZ-binding motif in human Brain-specific angiogenesis inhibitor 1 (BAI1) that binds to the PDZ domain of human Membrane-associated guanylate kinase inverted 2 (MAGI2) |
Record No : 72 |
| Instance ID | 12188 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | DLQTEV | | Bait Uniprot Accession | O14514 | | Bait Uniprot Identifier | BAI1_HUMAN | | Bait Gene Name | BAI1 | | Sequence Position | 1579-1584 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | PDZ Domain Proteomic Array | | Interaction ID | 22188 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23782696 | | Comments | C-terminal class 1 PDZ-binding motif in human Brain-specific angiogenesis inhibitor 1 (BAI1) that binds to the PDZ domain of human Membrane-associated guanylate kinase inverted 3 (MAGI3) |
Record No : 73 |
| Instance ID | 12189 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | DLQTEV | | Bait Uniprot Accession | O14514 | | Bait Uniprot Identifier | BAI1_HUMAN | | Bait Gene Name | BAI1 | | Sequence Position | 1579-1584 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | PDZ Domain Proteomic Array | | Interaction ID | 22189 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23782696 | | Comments | C-terminal class 1 PDZ-binding motif in human Brain-specific angiogenesis inhibitor 1 (BAI1) that binds to the PDZ domain of human InaD-like protein (INADL) |
Record No : 74 |
| Instance ID | 12190 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | DLQTEV | | Bait Uniprot Accession | O14514 | | Bait Uniprot Identifier | BAI1_HUMAN | | Bait Gene Name | BAI1 | | Sequence Position | 1579-1584 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | PDZ Domain Proteomic Array | | Interaction ID | 22190 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23782696 | | Comments | C-terminal class 1 PDZ-binding motif in human Brain-specific angiogenesis inhibitor 1 (BAI1) that binds to the PDZ domain of human Disks large homolog 1 (DLG1/SAP97) |
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