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Total : 180 Records
Record No : 1 |
| Instance ID | 10069 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSPSMP | | Bait Uniprot Accession | P30305 | | Bait Uniprot Identifier | MPIP2_HUMAN | | Bait Gene Name | CDC25B | | Sequence Position | 320-325 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence technology; GFP tag; Co-IP; Mutation analysis; Western blot | | Interaction ID | 20069 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20801879 | | Comments | 14-3-3 binding site (pS-323) in the human Dual specificity phosphatase Cdc25B, a key regulator of entry into mitosis, that mediates binding to 14-3-3 protein beta [mitotic phosphorylation of Ser321 enhances the dephosphorylation of Ser(323) to block 14-3-3 binding to this site] |
Record No : 2 |
| Instance ID | 10070 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSPSMP | | Bait Uniprot Accession | P30305 | | Bait Uniprot Identifier | MPIP2_HUMAN | | Bait Gene Name | CDC25B | | Sequence Position | 320-325 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence technology; GFP tag; Co-IP; Mutation analysis; Western blot | | Interaction ID | 20070 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20801879 | | Comments | 14-3-3 binding site (pS-323) in the human Dual specificity phosphatase Cdc25B, a key regulator of entry into mitosis, that mediates binding to 14-3-3 protein epsilon [mitotic phosphorylation of Ser321 enhances the dephosphorylation of Ser(323) to block 14-3-3 binding to this site] |
Record No : 3 |
| Instance ID | 10071 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSPSMP | | Bait Uniprot Accession | P30307 | | Bait Uniprot Identifier | MPIP3_HUMAN | | Bait Gene Name | CDC25C | | Sequence Position | 213-218 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Western blot; Alanine scanning | | Interaction ID | 20071 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9278512 | | Comments | 14-3-3 binding site (pS-216) in the human Dual specificity phosphatase Cdc25C that mediates binding to 14-3-3 protein beta |
Record No : 4 |
| Instance ID | 10072 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSRSCR | | Bait Uniprot Accession | P04233 | | Bait Uniprot Identifier | HG2A_HUMAN | | Bait Gene Name | CD74 | | Sequence Position | 5-10 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20072 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9448284 | | Comments | 14-3-3 binding site (pS-8) in the human HLA class II histocompatibility antigen gamma chain (CD74) that mediates binding to 14-3-3 protein eta |
Record No : 5 |
| Instance ID | 10099 | | Regular Expression | [^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS] | | Motif Instance | KNQFIAGIENFDAKKLKHT | | Bait Uniprot Accession | O97428 | | Bait Uniprot Identifier | O97428_DROME | | Bait Gene Name | cib | | Sequence Position | 91-109 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Subcellular preparation; Cross linking studies; ITC; Structure based prediction; Sequence based prediction; X-ray crystallography | | Interaction ID | 20099 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11030623, 16275905 | | Comments | The WH2 motif (91-109) in Drosophila ciboulot that mediates its interaction with the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 6 |
| Instance ID | 10100 | | Regular Expression | [^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS] | | Motif Instance | QQSIFEGITAFNQNNLKHT | | Bait Uniprot Accession | O97428 | | Bait Uniprot Identifier | O97428_DROME | | Bait Gene Name | cib | | Sequence Position | 53-71 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Subcellular preparation; Cross linking studies; ITC; Structure based prediction; Sequence based prediction; X-ray crystallography | | Interaction ID | 20100 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11030623, 16275905 | | Comments | The WH2 motif (53-71) in Drosophila ciboulot that mediates its interaction with the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 7 |
| Instance ID | 10160 | | Regular Expression | xKENx | | Motif Instance | SKENQ | | Bait Uniprot Accession | Q12834 | | Bait Uniprot Identifier | CDC20_HUMAN | | Bait Gene Name | CDC20 | | Sequence Position | 96-100 | | Critical Residues | P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Mutation analysis | | Interaction ID | 20160 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10733526 | | Comments | APCC-binding Destruction motif comprising a highly conserved KEN sequence (KEN Box) within human CDC20 that is preferentially recognised by the APC/C coactivator Cdh1 for recruitment to the APC/C complex leading to ubiquitination and proteasome-mediated degradation |
Record No : 8 |
| Instance ID | 10161 | | Regular Expression | xKENx | | Motif Instance | KKENG | | Bait Uniprot Accession | Q99741 | | Bait Uniprot Identifier | CDC6_HUMAN | | Bait Gene Name | CDC6 | | Sequence Position | 80-84 | | Critical Residues | P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20161 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10995389 | | Comments | APCC-binding Destruction motif comprising a highly conserved KEN sequence (KEN Box) within human CDC6 that is preferentially recognised by the APC/C coactivator CDH1 for APC-CDH1-dependent proteolysis of CDC6 in early G1 phase and in quiescent cells |
Record No : 9 |
| Instance ID | 10165 | | Regular Expression | xKENx | | Motif Instance | NKENA | | Bait Uniprot Accession | P27895 | | Bait Uniprot Identifier | CIN8_YEAST | | Bait Gene Name | CIN8 | | Sequence Position | 931-935 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20165 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11694576 | | Comments | KEN-box motif in the Saccharomyces cerevisiae kinesin-related motor protein Cin8p that is required for its degradation by the anaphase-promoting complex ubiquitin ligase and its late mitosis regulator Cdh1p |
Record No : 10 |
| Instance ID | 10166 | | Regular Expression | xKENx | | Motif Instance | EKENE | | Bait Uniprot Accession | Q96FF9 | | Bait Uniprot Identifier | CDCA5_HUMAN | | Bait Gene Name | CDCA5 | | Sequence Position | 87-91 | | Critical Residues | P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20166 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15837422 | | Comments | KEN-box motif in human Sororin (CDCA5/p35) that is sufficient for anaphase-promoting complex (APC)-dependent ubiquitination by mediating interaction with the APC/C coactivator fzr (fizzy-related/cdh1/hct1) |
Record No : 11 |
| Instance ID | 10167 | | Regular Expression | xKENx | | Motif Instance | DKENM | | Bait Uniprot Accession | Q8WWK9 | | Bait Uniprot Identifier | CKAP2_HUMAN | | Bait Gene Name | CKAP2 | | Sequence Position | 80-84 | | Critical Residues | P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Ubiquitinase assay | | Interaction ID | 20167 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17376772 | | Comments | KEN-box motif in human CKAP2, a spindle-associated protein, required for ubiquitination and degradation of CKAP2 mediated by the APC/C coactivator Cdh1 |
Record No : 12 |
| Instance ID | 10168 | | Regular Expression | xKENx | | Motif Instance | NKEND | | Bait Uniprot Accession | P30307 | | Bait Uniprot Identifier | MPIP3_HUMAN | | Bait Gene Name | CDC25C | | Sequence Position | 150-154 | | Critical Residues | P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Competition binding | | Interaction ID | 20168 | | Interacting Domain | Unknown | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11842186 | | Comments | KEN-box motif in human Cdc25C that mediates arsenite-induced ubiquitination of Cdc25C that may be involved in the arsenite-induced proteolytic down-regulation of Cdc25C activity causing cell cycle arrest at G(2)/M phase leading to suppression of cell proliferation and reduced cell viability |
Record No : 13 |
| Instance ID | 10180 | | Regular Expression | x[ILM]R$ | | Motif Instance | RIR | | Bait Uniprot Accession | Q9S7I8 | | Bait Uniprot Identifier | CDC22_ARATH | | Bait Gene Name | CDC20-2 | | Sequence Position | 445-447 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 20180 | | Interacting Domain | Tetratricopeptide repeats | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17944809, 21687678 | | Comments | Interaction between Arabidopsis CDC20-2 and one of the Arabidopsis CDC27 subunit in the anaphase-promoting complex (APC/C), HBT/CDC27B, probably mediated by the IR tail of AtCDC20.2 |
Record No : 14 |
| Instance ID | 10181 | | Regular Expression | x[ILM]R$ | | Motif Instance | RIR | | Bait Uniprot Accession | Q9SZA4 | | Bait Uniprot Identifier | CDC21_ARATH | | Bait Gene Name | CDC20-1 | | Sequence Position | 455-457 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 20181 | | Interacting Domain | Tetratricopeptide repeats | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17944809, 21687678 | | Comments | Interaction between Arabidopsis CDC20-1 and one of the Arabidopsis CDC27 subunit in the anaphase-promoting complex (APC/C), HBT/CDC27B, probably mediated by the IR tail of AtCDC20.1 |
Record No : 15 |
| Instance ID | 10182 | | Regular Expression | x[ILM]R$ | | Motif Instance | HIR | | Bait Uniprot Accession | Q3E906 | | Bait Uniprot Identifier | CD205_ARATH | | Bait Gene Name | CDC20-5 | | Sequence Position | 409-411 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 20182 | | Interacting Domain | Tetratricopeptide repeats | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17944809 | | Comments | Interaction between Arabidopsis CDC20-5 and one of the Arabidopsis CDC27 subunit in the anaphase-promoting complex (APC/C), HBT/CDC27B, probably mediated by the IR tail of AtCDC20.5 |
Record No : 16 |
| Instance ID | 10185 | | Regular Expression | x[ILM]R$ | | Motif Instance | GIR | | Bait Uniprot Accession | Q12834 | | Bait Uniprot Identifier | CDC20_HUMAN | | Bait Gene Name | CDC20 | | Sequence Position | 497-499 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Ubiquitinase assay; Peptide binding to perpetrator; Competition binding; Pull down | | Interaction ID | 20185 | | Interacting Domain | Tetratricopeptide repeats | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12956947 | | Comments | Conserved C-terminal motif found in human CDC20 that mediates binding to the TPR domain in APC3 |
Record No : 17 |
| Instance ID | 10186 | | Regular Expression | x[ILM]R$ | | Motif Instance | GIR | | Bait Uniprot Accession | Q960N3 | | Bait Uniprot Identifier | CORT_DROME | | Bait Gene Name | cort | | Sequence Position | 481-483 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Western blot; Knock out; Co-IP | | Interaction ID | 20186 | | Interacting Domain | Tetratricopeptide repeats | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18020708 | | Comments | The C-terminal IR tail motif in Drosophila protein CORT that may be responsible for its physical association with Drosophila Cdc27, a tetratricopeptide repeat core subunit of the APC/C |
Record No : 18 |
| Instance ID | 10188 | | Regular Expression | x[ILM]R$ | | Motif Instance | LIR | | Bait Uniprot Accession | P26309 | | Bait Uniprot Identifier | CDC20_YEAST | | Bait Gene Name | CDC20 | | Sequence Position | 608-610 | | Critical Residues | P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Tandem affinity purification; Mutation disrupting interaction; Mutation analysis; Pull down; Ubiquitinase assay; Alanine scanning; Co-IP; Radiolabel; comigration in non denaturing gel electrophoresis | | Interaction ID | 20188 | | Interacting Domain | Tetratricopeptide repeats | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15916961, 19362536, 21118994, 12574115 | | Comments | The C-terminal IR tail motif in yeast CDC20 that mediates binding to the Tetratricopeptide repeats domain of the APC/C subunit Cdc27 |
Record No : 19 |
| Instance ID | 10189 | | Regular Expression | x[ILM]R$ | | Motif Instance | QIR | | Bait Uniprot Accession | P53197 | | Bait Uniprot Identifier | CDH1_YEAST | | Bait Gene Name | CDH1 | | Sequence Position | 564-566 | | Critical Residues | P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Tandem affinity purification; Mutation disrupting interaction; Mutation analysis; Pull down; Ubiquitinase assay; Alanine scanning; Radiolabel; comigration in non denaturing gel electrophoresis | | Interaction ID | 20189 | | Interacting Domain | Tetratricopeptide repeats | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15916961, 19362536, 12574115 | | Comments | The C-terminal IR tail motif in yeast CDH1 that mediates binding to the Tetratricopeptide repeats domain of the APC/C subunit Cdc27 |
Record No : 20 |
| Instance ID | 10190 | | Regular Expression | [DE]R[YFH][ILFVM][PAG]xR | | Motif Instance | DRYIPHR | | Bait Uniprot Accession | Q12834 | | Bait Uniprot Identifier | CDC20_HUMAN | | Bait Gene Name | CDC20 | | Sequence Position | 77-83 | | Critical Residues | P1; P2; P3; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20190 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19026787 | | Comments | A short, highly conserved motif in human CDC20 that possibly interacts with the catalytic Apc2 subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle |
Record No : 21 |
| Instance ID | 10191 | | Regular Expression | [DE]R[YFH][ILFVM][PAG]xR | | Motif Instance | DRFIPNR | | Bait Uniprot Accession | Q8AVG7 | | Bait Uniprot Identifier | Q8AVG7_XENLA | | Bait Gene Name | cdc20 | | Sequence Position | 85-91 | | Critical Residues | P1; P2; P3; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down(GST tag); Mutation analysis | | Interaction ID | 20191 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19026787, 22713866 | | Comments | A short, highly conserved motif in Xenopus Cdc20 protein that possibly interacts with the catalytic Apc2 subunit of the anaphase promoting complex/cyclosome (APC/C) |
Record No : 22 |
| Instance ID | 10193 | | Regular Expression | DR[YFH][ILFVM][PA]xx | | Motif Instance | DRYIPSR | | Bait Uniprot Accession | P53197 | | Bait Uniprot Identifier | CDH1_YEAST | | Bait Gene Name | CDH1 | | Sequence Position | 55-61 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20193 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11566880, 16481473 | | Comments | Motif present in yeast Hct1 (Cdh1) that mediates its interaction with G2/mitotic-specific cyclin-2 |
Record No : 23 |
| Instance ID | 10194 | | Regular Expression | DR[YFH][ILFVM][PA]xx | | Motif Instance | DRYIPIL | | Bait Uniprot Accession | P26309 | | Bait Uniprot Identifier | CDC20_YEAST | | Bait Gene Name | CDC20 | | Sequence Position | 144-150 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20194 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21118994, 16481473 | | Comments | Motif present in yeast CDC20 for mediating its interaction with yeast meiosis-specific activator Ama1p |
Record No : 24 |
| Instance ID | 10202 | | Regular Expression | ^M{0,1}AxPx | | Motif Instance | MAVPF | | Bait Uniprot Accession | O14757 | | Bait Uniprot Identifier | CHK1_HUMAN | | Bait Gene Name | CHEK1 | | Sequence Position | 1-5 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Co-IP | | Interaction ID | 20202 | | Interacting Domain | BIR domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14759516 | | Comments | IAP-binding motif in human Cell cycle checkpoint kinase CHK1 that mediates the interaction between CHK1 and the BIR3 domain of XIAP |
Record No : 25 |
| Instance ID | 10204 | | Regular Expression | DAxPx | | Motif Instance | DAKPD | | Bait Uniprot Accession | P55210 | | Bait Uniprot Identifier | CASP7_HUMAN | | Bait Gene Name | CASP7 | | Sequence Position | 23-27 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20204 | | Interacting Domain | BIR domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15580265, 19258326 | | Comments | BIR domain-binding motif of human Caspase-7 that mediates binding to the BIR domains of Baculoviral IAP repeat-containing protein 2 |
Record No : 26 |
| Instance ID | 10205 | | Regular Expression | DAxPx | | Motif Instance | DATPF | | Bait Uniprot Accession | P55211 | | Bait Uniprot Identifier | CASP9_HUMAN | | Bait Gene Name | CASP9 | | Sequence Position | 315-319 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; X-ray crystallography; SPR | | Interaction ID | 20205 | | Interacting Domain | BIR domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12620238, 19153467 | | Comments | BIR domain-binding motif of human Caspase-9 that mediates binding to the BIR domains of Baculoviral IAP repeat-containing protein 4 (XIAP) |
Record No : 27 |
| Instance ID | 10219 | | Regular Expression | ((SP)|([ED]x{0,1}))[IV]W[IVL]xR | | Motif Instance | EIWVLR | | Bait Uniprot Accession | Q8WXD9 | | Bait Uniprot Identifier | CSKI1_HUMAN | | Bait Gene Name | CASKIN1 | | Sequence Position | 374-379 | | Critical Residues | P2; P3; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Alanine scanning | | Interaction ID | 20219 | | Interacting Domain | CaMK domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21763699 | | Comments | The CASK-CaMK-binding motif in human CASKIN1 that mediates specific binding to the CaMK domain of the CASK protein |
Record No : 28 |
| Instance ID | 10221 | | Regular Expression | ((SP)|([ED]x{0,1}))[IV]W[IVL]xR | | Motif Instance | EIWVLR | | Bait Uniprot Accession | Q8VHK2 | | Bait Uniprot Identifier | CSKI1_RAT | | Bait Gene Name | Caskin1 | | Sequence Position | 374-379 | | Critical Residues | P2; P3; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20221 | | Interacting Domain | CaMK domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12040031 | | Comments | The CASK-CaMK-binding motif in rat Caskin1 that mediates specific binding to the CaMK domain of the rat Peripheral plasma membrane protein CASK |
Record No : 29 |
| Instance ID | 10225 | | Regular Expression | [ED]x{0,2}[ED]x{0,2}[EDQ]x{0,1}[YF]$ | | Motif Instance | DDETF | | Bait Uniprot Accession | P30622 | | Bait Uniprot Identifier | CLIP1_HUMAN | | Bait Gene Name | CLIP1 | | Sequence Position | 1434-1438 | | Critical Residues | P3; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Mutation analysis | | Interaction ID | 20225 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16148041, 17828277 | | Comments | The CLIP1 tail that is essential for complex formation with the CAP-Gly domain of the dynactin subunit p150Glued |
Record No : 30 |
| Instance ID | 10249 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | MRVTDFFSQSKRG | | Bait Uniprot Accession | Q9I9A7 | | Bait Uniprot Identifier | CDT1_XENLA | | Bait Gene Name | cdt1 | | Sequence Position | 4-16 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Co-IP; Ubiquitinase assay; Western blot; Alanine scanning; Mutation analysis | | Interaction ID | 20249 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19595719 | | Comments | Docking of a specialized PIP Box motif of Xenopus DNA replication factor Cdt1 onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2 |
Record No : 31 |
| Instance ID | 10250 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | MRVTDFFSQSKRG | | Bait Uniprot Accession | Q9I9A7 | | Bait Uniprot Identifier | CDT1_XENLA | | Bait Gene Name | cdt1 | | Sequence Position | 4-16 | | Critical Residues | P11 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Co-IP; Ubiquitinase assay; Western blot; Alanine scanning; Mutation analysis | | Interaction ID | 20250 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19595719 | | Comments | Docking of a specialized PIP Box motif of Xenopus DNA replication factor Cdt1 onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt3 |
Record No : 32 |
| Instance ID | 10251 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | PLISDFFAKRKRS | | Bait Uniprot Accession | P49918 | | Bait Uniprot Identifier | CDN1C_HUMAN | | Bait Gene Name | CDKN1C | | Sequence Position | 270-282 | | Critical Residues | P5; P7; P9; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 20251 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | IMAGe syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 22634751 | | Comments | PIP box motif in human Cyclin-dependent kinase inhibitor p57 (CDKN1C) that is required to bind PCNA |
Record No : 33 |
| Instance ID | 10252 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | RRVTDFFARRRP | | Bait Uniprot Accession | Q9H211 | | Bait Uniprot Identifier | CDT1_HUMAN | | Bait Gene Name | CDT1 | | Sequence Position | 4-15 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | RNA interference;Western blot; Co-IP | | Interaction ID | 20252 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16861906 | | Comments | The human homologue of Drosophila L2DTL or fission yeast CDT2 (DTL) interacts with PCNA and regulates human DNA replication factor CDT1 proteolysis in response to DNA damage, through the conserved PIP box motif |
Record No : 34 |
| Instance ID | 10253 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | RRVTDFFARRRP | | Bait Uniprot Accession | Q9H211 | | Bait Uniprot Identifier | CDT1_HUMAN | | Bait Gene Name | CDT1 | | Sequence Position | 4-15 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | RNA interference;Western blot; Co-IP | | Interaction ID | 20253 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16861906 | | Comments | The human homologue of Drosophila L2DTL or fission yeast CDT2 (DTL) interacts with PCNA and regulates human DNA replication factor CDT1 proteolysis in response to DNA damage, through the conserved PIP box motif |
Record No : 35 |
| Instance ID | 10254 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | TSMTDFYHSKRRL | | Bait Uniprot Accession | P38936 | | Bait Uniprot Identifier | CDN1A_HUMAN | | Bait Gene Name | CDKN1A | | Sequence Position | 145-157 | | Critical Residues | P10; P11; P12 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Fluorescence technology; RNA interference; Ubiquitinase assay; Western blot; Co-IP; Alanine scanning; Co-IP | | Interaction ID | 20254 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18703516, 18794347 | | Comments | PCNA binding domain in CDK inhibitor p21 (CDKN1A) that is responsible for degradation of p21 by PCNA-coupled Cul4-DDB1(Cdt2)-dependent proteolysis |
Record No : 36 |
| Instance ID | 10255 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | TSMTDFYHSKRRL | | Bait Uniprot Accession | P38936 | | Bait Uniprot Identifier | CDN1A_HUMAN | | Bait Gene Name | CDKN1A | | Sequence Position | 145-157 | | Critical Residues | P10; P11; P12 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Fluorescence technology; RNA interference; Ubiquitinase assay; Western blot; Co-IP; Alanine scanning; Co-IP | | Interaction ID | 20255 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18703516, 18794347 | | Comments | PCNA binding domain in CDK inhibitor p21 (CDKN1A) that is responsible for degradation of p21 by PCNA-coupled Cul4-DDB1(Cdt2)-dependent proteolysis |
Record No : 37 |
| Instance ID | 10269 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | PIDLR | | Bait Uniprot Accession | Q91647 | | Bait Uniprot Identifier | Q91647_XENLA | | Bait Gene Name | cbx4 | | Sequence Position | 455-459 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 20269 | | Interacting Domain | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9858600 | | Comments | Xenopus homolog of C-terminal binding protein 1 (XCtBP1) interacts with Xenopus Pc (XPc), homolog of the Drosophila PcG protein Pc, through the PxDLS motif |
Record No : 38 |
| Instance ID | 10271 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | PIDLR | | Bait Uniprot Accession | O00257 | | Bait Uniprot Identifier | CBX4_HUMAN | | Bait Gene Name | CBX4 | | Sequence Position | 472-476 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20271 | | Interacting Domain | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9858600 | | Comments | The C-terminal fragment of human Pc 2 (HPC2), homolog of the Drosophila PcG protein Pc, to which human CtBP2 binds |
Record No : 39 |
| Instance ID | 10288 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RRLF | | Bait Uniprot Accession | P38936 | | Bait Uniprot Identifier | CDN1A_HUMAN | | Bait Gene Name | CDKN1A | | Sequence Position | 19-22 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20288 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11438644 | | Comments | The cyclin recognition site (RxL motif) found in human cyclin-dependent kinase inhibitor p21Cip1/Waf1 (CDKN1A) required for p21 interaction with cyclin E/Cdk2 |
Record No : 40 |
| Instance ID | 10289 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RSLF | | Bait Uniprot Accession | P49918 | | Bait Uniprot Identifier | CDN1C_HUMAN | | Bait Gene Name | CDKN1C | | Sequence Position | 31-34 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20289 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10713702 | | Comments | Human Cyclin-dependent kinase inhibitor p57Kip2 associates with itself by using the NH2 terminal domain to form a homodimeric species which interacts with and inhibits the cyclin D1-Cdk4 complexes |
Record No : 41 |
| Instance ID | 10292 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RRLVF | | Bait Uniprot Accession | Q99741 | | Bait Uniprot Identifier | CDC6_HUMAN | | Bait Gene Name | CDC6 | | Sequence Position | 94-98 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Pull down | | Interaction ID | 20292 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16707497, 9889196 | | Comments | Cyclin A/CDK2 binds hCDC6 via the RxL motif in the N‐terminus of hCDC6 |
Record No : 42 |
| Instance ID | 10293 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RNLF | | Bait Uniprot Accession | P46527 | | Bait Uniprot Identifier | CDN1B_HUMAN | | Bait Gene Name | CDKN1B | | Sequence Position | 30-33 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; X-ray crystallography; Mutation analysis | | Interaction ID | 20293 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12501191, 8684460, 9488039 | | Comments | The cyclin recognition site (RxL motif) found in human cyclin-dependent kinase inhibitor p27Kip1 (CDKN1B) required for p21 interaction with cyclin E/Cdk2 |
Record No : 43 |
| Instance ID | 10299 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RRLLF | | Bait Uniprot Accession | P30304 | | Bait Uniprot Identifier | MPIP1_HUMAN | | Bait Gene Name | CDC25A | | Sequence Position | 11-15 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20299 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 9234691 | | Comments | The cyclin-binding RxL motif near the N terminus of human Cdc25A that mediates the association of Cdc25A with cyclin E and selectively interferes with the dephosphorylation of cyclin E-cdk2 |
Record No : 44 |
| Instance ID | 10302 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RELFI | | Bait Uniprot Accession | P39880 | | Bait Uniprot Identifier | CUX1_HUMAN | | Bait Gene Name | CUX1 | | Sequence Position | 1301-1305 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down(GST tag) | | Interaction ID | 20302 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11584018 | | Comments | The cyclin-binding RxL motif in human Homeobox protein cux-1 or CCAAT displacement protein (CDP) that is required for its interaction with Cyclin A-Cdk Complex resulting in the phosphorylation of CDP/Cux by cyclin A-Cdk1, which contributes to down-modulate CDP/Cux activity as cells progress into the G(2) phase of the cell cycle |
Record No : 45 |
| Instance ID | 10412 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YTIDELF | | Bait Uniprot Accession | P12962 | | Bait Uniprot Identifier | CAF20_YEAST | | Bait Gene Name | CAF20 | | Sequence Position | 4-10 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag) | | Interaction ID | 20412 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9118949 | | Comments | In the yeast Saccharomyces cerevisiae, Cap-associated protein CAF20 or p20 is a regulator of eIF4E activity which represses cap-dependent initiation of translation by interfering with the interaction of eIF4E with eIF4G |
Record No : 46 |
| Instance ID | 10417 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YTRSRLM | | Bait Uniprot Accession | Q9VMA3 | | Bait Uniprot Identifier | CUP_DROME | | Bait Gene Name | cup | | Sequence Position | 327-333 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 20417 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14685270 | | Comments | The eIF4E binding motif in Drosophila Cup protein that mediates its interaction with eIF4E, which blocks the binding of eIF4G to eIF4E and mediates an indirect interaction between Smaug and eIF4E, resulting in translational repression |
Record No : 47 |
| Instance ID | 10454 | | Regular Expression | [DE]HxY | | Motif Instance | DHDY | | Bait Uniprot Accession | Q9NS37 | | Bait Uniprot Identifier | ZHANG_HUMAN | | Bait Gene Name | CREBZF | | Sequence Position | 303-306 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag); Mammalian two-hybrid assay | | Interaction ID | 20454 | | Interacting Domain | Galactose oxidase, central domain | | Disease Association(s) | Herpes simplex virus (HSV) infection | | Inhibitor(s) | Unknown | | Reference(s) | 15705566, 10871379 | | Comments | Human HCF-binding transcription factor Zhangfei (CREB/ATF bZIP transcription factor or CREBZF) associates with human Host cell factor 1 through a conserved sequence motif |
Record No : 48 |
| Instance ID | 10457 | | Regular Expression | [DE]HxY | | Motif Instance | EHSY | | Bait Uniprot Accession | P29747 | | Bait Uniprot Identifier | CREBA_DROME | | Bait Gene Name | CrebA | | Sequence Position | 64-67 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 20457 | | Interacting Domain | Galactose oxidase, central domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9658067, 9389645 | | Comments | The Drosophila protein dCREB-A contains an HCF-binding motif that has been implicated in its association with human Host Cell Factor (HCF-1) |
Record No : 49 |
| Instance ID | 10465 | | Regular Expression | [DE]HxY | | Motif Instance | DHTY | | Bait Uniprot Accession | O43889 | | Bait Uniprot Identifier | CREB3_HUMAN | | Bait Gene Name | CREB3 | | Sequence Position | 78-81 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag); Mammalian two-hybrid assay; Mutation analysis | | Interaction ID | 20465 | | Interacting Domain | Galactose oxidase, central domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9658067, 9389645 | | Comments | The human basic domain leucine zipper protein, Luman (CREB3/LZIP), interacts with the cellular transcription factor HCF-1 through its HCF-1-binding motif (HBM) |
Record No : 50 |
| Instance ID | 10468 | | Regular Expression | P[MVLIRWY]V[MVLIAS][LM] | | Motif Instance | PVVVL | | Bait Uniprot Accession | Q9QWF0 | | Bait Uniprot Identifier | CAF1A_MOUSE | | Bait Gene Name | Chaf1a | | Sequence Position | 222-226 | | Critical Residues | P1; P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | NMR | | Interaction ID | 20468 | | Interacting Domain | Chromo shadow domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14765118 | | Comments | The chromo shadow domain from mouse HP1 beta (Cbx1) bound to a peptide containing a consensus PXVXL motif found in mouse Chaf1a (CAF‐1) |
Record No : 51 |
| Instance ID | 10476 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | FYATFLIQEYFRKFKKRKEQ | | Bait Uniprot Accession | P15381 | | Bait Uniprot Identifier | CAC1C_RABIT | | Bait Gene Name | CACNA1C | | Sequence Position | 1648-1667 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Fluorescence polarization spectroscopy; NMR | | Interaction ID | 20476 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21757287 | | Comments | The Calmodulin binding IQ motif of the rabbit Voltage-gated calcium channel subunit alpha Cav1.2 (CACNA1C) that binds to the apo C-domain of rat Calmodulin (CaM) |
Record No : 52 |
| Instance ID | 10477 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | FYATFLIQEYFRKFKKRKEQ | | Bait Uniprot Accession | Q13936 | | Bait Uniprot Identifier | CAC1C_HUMAN | | Bait Gene Name | CACNA1C | | Sequence Position | 1666-1685 | | Critical Residues | P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Alanine scanning; X-ray crystallography | | Interaction ID | 20477 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16338416 | | Comments | Human Ca2+-calmodulin binds to the hydrophobic IQ motif of the human cardiac Ca(v)1.2 calcium channel that is required for its Ca2+-dependent inactivation (CDI) and facilitation (CDF) |
Record No : 53 |
| Instance ID | 10504 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | IVAALKIQHAFRNYNRKKAM | | Bait Uniprot Accession | Q2WEL1 | | Bait Uniprot Identifier | Q2WEL1_ORYSA | | Bait Gene Name | CBT | | Sequence Position | 758-777 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Far Western blotting; Mutation analysis; EMSA | | Interaction ID | 20504 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16192280 | | Comments | Calmodulin (CaM) binds to the IQ motif of a calmodulin-binding transcription factor from rice, OsCBT (Oryza sativa CaM-binding transcription factor) |
Record No : 54 |
| Instance ID | 10506 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | FYATFLIQEHFRKFMKRQEE | | Bait Uniprot Accession | Q13698 | | Bait Uniprot Identifier | CAC1S_HUMAN | | Bait Gene Name | CACNA1S | | Sequence Position | 1523-1542 | | Critical Residues | P10; P15; P18 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; SPR; X-ray crystallography | | Interaction ID | 20506 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19473981 | | Comments | Human Calmodulin (CALM1) binds to the IQ motif in the alpha(1) subunit of human Voltage-gated calcium channel subunit alpha Ca(V)1.1 |
Record No : 55 |
| Instance ID | 10520 | | Regular Expression | [KR][IV][LV]xxxxxP | | Motif Instance | KILRLSGKP | | Bait Uniprot Accession | Q12834 | | Bait Uniprot Identifier | CDC20_HUMAN | | Bait Gene Name | CDC20 | | Sequence Position | 129-137 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Fluorescence technology | | Interaction ID | 20520 | | Interacting Domain | HORMA domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11804586 | | Comments | MAD2 binding motif in human Cell division cycle protein 20 homolog that interacts with Mitotic spindle assembly checkpoint protein MAD2A |
Record No : 56 |
| Instance ID | 10574 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | QLVLLLH | | Bait Uniprot Accession | Q92793 | | Bait Uniprot Identifier | CBP_HUMAN | | Bait Gene Name | CREBBP | | Sequence Position | 357-363 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 20574 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902 | | Comments | The NR box motif (357-363) of human CREB-binding protein (CREBBP/CBP) that is necessary for binding the human Estrogen receptor (ESR) |
Record No : 57 |
| Instance ID | 10575 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | QLSELLR | | Bait Uniprot Accession | Q92793 | | Bait Uniprot Identifier | CBP_HUMAN | | Bait Gene Name | CREBBP | | Sequence Position | 69-75 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 20575 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902 | | Comments | The NR box motif (69-75) of human CREB-binding protein (CREBBP/CBP) that is necessary for binding the human Estrogen receptor (ESR) |
Record No : 58 |
| Instance ID | 10617 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QATLARFFTS | | Bait Uniprot Accession | P04819 | | Bait Uniprot Identifier | DNLI1_YEAST | | Bait Gene Name | CDC9 | | Sequence Position | 38-47 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | SPR; Pull down; X-ray crystallography | | Interaction ID | 20617 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17308348 | | Comments | The conserved PCNA interaction motif of Cdc9, yeast DNA ligase I, that mediates interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30) |
Record No : 59 |
| Instance ID | 10620 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QTSMTDFYHS | | Bait Uniprot Accession | P38936 | | Bait Uniprot Identifier | CDN1A_HUMAN | | Bait Gene Name | CDKN1A | | Sequence Position | 144-153 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20620 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8861913 | | Comments | The C-terminal PCNA binding PIP box motif of human Cyclin-dependent kinase inhibitor 1 (CDKN1A/p21/WAF1/CIP1) that mediates interaction with human Proliferating cell nuclear antigen (PCNA/Cyclin) |
Record No : 60 |
| Instance ID | 10622 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QKSIMSFFGK | | Bait Uniprot Accession | P30261 | | Bait Uniprot Identifier | DPOD3_SCHPO | | Bait Gene Name | cdc27 | | Sequence Position | 362-371 | | Critical Residues | P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Co-IP; Pull down(GST tag); Western blot | | Interaction ID | 20622 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10698951 | | Comments | Essential interaction between the fission yeast DNA polymerase delta subunit Cdc27 and Pcn1 (PCNA) mediated through a C-terminal PCNA binding PIP box motif |
Record No : 61 |
| Instance ID | 10629 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | LEITEL | | Bait Uniprot Accession | Q9H251 | | Bait Uniprot Identifier | CAD23_HUMAN | | Bait Gene Name | CDH23 | | Sequence Position | 3349-3354 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | NMR; Pull down(GST tag); Western blot | | Interaction ID | 20629 | | Interacting Domain | PDZ domain | | Disease Association(s) | Usher's Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 19297620 | | Comments | The second PDZ Domain of Harmonin (USH1C) specifically interacts with the C-terminal class 1 PDZ domain-binding motif of human Cadherin-23 |
Record No : 62 |
| Instance ID | 10630 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | WFDTDL | | Bait Uniprot Accession | P35222 | | Bait Uniprot Identifier | CTNB1_HUMAN | | Bait Gene Name | CTNNB1 | | Sequence Position | 776-781 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | ITC; X-ray crystallography | | Interaction ID | 20630 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18835279 | | Comments | C-terminal class 1 PDZ-binding motif in human Beta-catenin that binds to the PDZ domain of mouse Tax-interacting protein-1 (TIP-1)/ Tax1-binding protein 3 (Tax1bp3) |
Record No : 63 |
| Instance ID | 10631 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | YKQTSV | | Bait Uniprot Accession | Q792Q4 | | Bait Uniprot Identifier | CRIPT_RAT | | Bait Gene Name | Cript | | Sequence Position | 96-101 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20631 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8674113 | | Comments | C-terminal class 1 PDZ-binding motif in rat Cysteine-rich PDZ-binding protein (Cript) that binds to the third PDZ domain of rat Dlg4 or Psd95 |
Record No : 64 |
| Instance ID | 10651 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | RRTTPV | | Bait Uniprot Accession | O88602 | | Bait Uniprot Identifier | CCG2_MOUSE | | Bait Gene Name | Cacng2 | | Sequence Position | 318-323 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Disordered | | Experimental Method(s) | Protein kinase assay; Mutation analysis; Western blot | | Interaction ID | 20651 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11805122 | | Comments | C-terminal class 1 PDZ-binding motif in mouse Neuronal voltage-gated calcium channel gamma-2 subunit/ Stargazin (Cacng2) that binds to the PDZ domain of mouse Dlg4/PSD-95/SAP-90 |
Record No : 65 |
| Instance ID | 10656 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | VQDTRL | | Bait Uniprot Accession | P13569 | | Bait Uniprot Identifier | CFTR_HUMAN | | Bait Gene Name | CFTR | | Sequence Position | 1475-1480 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; Far Western blotting; SPR; Pull down; Mutation analysis; Western blot | | Interaction ID | 20656 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11304524, 9677412 | | Comments | C-terminal PDZ domain-binding motif in human Cystic fibrosis transmembrane conductance regulator (CFTR) that mediates binding to the first PDZ domain of the Na+/H+ exchanger regulatory factor (NHERF/EBP50) |
Record No : 66 |
| Instance ID | 10673 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | LNSTTL | | Bait Uniprot Accession | P51790 | | Bait Uniprot Identifier | CLCN3_HUMAN | | Bait Gene Name | CLCN3 | | Sequence Position | 861-866 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down | | Interaction ID | 20673 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11967229 | | Comments | C-terminal class 1 PDZ-binding motif in ClC-3B, a splicing variant of human Chloride transporter ClC-3 (CLCN3) that mediates binding to the PDZ domain of human EBP50/NHERF1/SLC9A3R1 |
Record No : 67 |
| Instance ID | 10675 | | Regular Expression | xxx[VLIFY]x[ACVILF]$ | | Motif Instance | QEELII | | Bait Uniprot Accession | P55284 | | Bait Uniprot Identifier | CADH5_MOUSE | | Bait Gene Name | Cdh5 | | Sequence Position | 779-784 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Fluorescence polarization spectroscopy; NMR | | Interaction ID | 20675 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20047332 | | Comments | The C-terminal class 2 PDZ-binding motif of mouse Vascular endothelial cadherin (VE-Cad)/ Cadherin-5 (Cdh5) that binds to the third PDZ domain of mouse Pard3 (par3-PDZ3) |
Record No : 68 |
| Instance ID | 10711 | | Regular Expression | xP[^P]I[^P][IV][^P] | | Motif Instance | TPIISIQ | | Bait Uniprot Accession | P53968 | | Bait Uniprot Identifier | CRZ1_YEAST | | Bait Gene Name | CRZ1 | | Sequence Position | 330-336 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20711 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11877380 | | Comments | In Saccharomyces cerevisiae, calcineurin positively regulates transcription in response to stress by dephosphorylating the transcription factor Crz1p/Tcn1p involving the calcineurin docking motif in Crz1p |
Record No : 69 |
| Instance ID | 10750 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | EFQNPLYS | | Bait Uniprot Accession | Q9XWD6 | | Bait Uniprot Identifier | CED1_CAEEL | | Bait Gene Name | ced-1 | | Sequence Position | 959-966 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Co-IP | | Interaction ID | 20750 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11729193 | | Comments | The PTB Domain of Cell death protein 6 (ced-6), an adapter protein of Caenorhabditis elegans, binds to the NPXY motif of Cell death abnormality protein 1 (ced-1) |
Record No : 70 |
| Instance ID | 10822 | | Regular Expression | [LIVMP]x{0,2}(T)Pxx([ST]) | | Motif Instance | LLTPPQS | | Bait Uniprot Accession | P24864 | | Bait Uniprot Identifier | CCNE1_HUMAN | | Bait Gene Name | CCNE1 | | Sequence Position | 393-399 | | Critical Residues | P3; P7 | | Motif PTM(s) | Phosphorylation at Thr-P3 & Ser-P7 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; ITC; Mutation analysis | | Interaction ID | 20822 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17434132, 14536078 | | Comments | The TPxxS phospho-dependent degron in Human G1/S-specific cyclin-E1 (CCNE1) that serves as a recognition motif for the SCF(FBW7) ubiquitin ligase, which mediates the degradation of cyclin E within catalytically active cyclin E-Cdk2 complexes and is not involved in the turnover of unbound or unphosphorylated cyclin E |
Record No : 71 |
| Instance ID | 10827 | | Regular Expression | xx[DE]x(T)PxK | | Motif Instance | SVEQTPRK | | Bait Uniprot Accession | P49918 | | Bait Uniprot Identifier | CDN1C_HUMAN | | Bait Gene Name | CDKN1C | | Sequence Position | 306-313 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Thr-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Ubiquitinase assay; Knock out; Co-IP; Alanine scanning | | Interaction ID | 20827 | | Interacting Domain | Leucine-rich repeats (LRR) | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12925736 | | Comments | The phospho-dependent degron in Human Cyclin-dependent kinase inhibitor 1C or p57Kip2 (CDKN1C) is recognised by Human F-box/LRR-repeat protein SKP2, which is responsible for regulating the cellular level of p57Kip2 by targeting it for ubiquitylation and proteolysis |
Record No : 72 |
| Instance ID | 10828 | | Regular Expression | xx[DE]x(T)PxK | | Motif Instance | AVEQTPRK | | Bait Uniprot Accession | P49919 | | Bait Uniprot Identifier | CDN1C_MOUSE | | Bait Gene Name | Cdkn1c | | Sequence Position | 338-345 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Thr-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Ubiquitinase assay; Knock out; Co-IP; Alanine scanning | | Interaction ID | 20828 | | Interacting Domain | Leucine-rich repeats (LRR) | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12925736 | | Comments | The phospho-dependent degron in Mouse Cyclin-dependent kinase inhibitor 1C or p57Kip2 (Cdkn1c) is recognised by Mouse F-box/LRR-repeat protein Skp2, which is responsible for regulating the cellular level of p57Kip2 by targeting it for ubiquitylation and proteolysis |
Record No : 73 |
| Instance ID | 10829 | | Regular Expression | xx[DE]x(T)PxK | | Motif Instance | SVEQTPKK | | Bait Uniprot Accession | P46527 | | Bait Uniprot Identifier | CDN1B_HUMAN | | Bait Gene Name | CDKN1B | | Sequence Position | 183-190 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Thr-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Ubiquitinase assay; Mutation analysis; X-ray crystallography | | Interaction ID | 20829 | | Interacting Domain | Leucine-rich repeats (LRR) | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16209941 | | Comments | The phospho-dependent degron in Human Cyclin-dependent kinase inhibitor 1B or p27Kip1 (CDKN1B) is recognised by Human F-box/LRR-repeat protein SKP2 depending on Thr-187 phosphorylation and causing ubiquitin-mediated proteolysis of the Cdk2 inhibitor p27Kip1 |
Record No : 74 |
| Instance ID | 10832 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGIHS | | Bait Uniprot Accession | P35222 | | Bait Uniprot Identifier | CTNB1_HUMAN | | Bait Gene Name | CTNNB1 | | Sequence Position | 32-37 | | Critical Residues | P1; P2; P3; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Protein kinase assay | | Interaction ID | 20832 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12820959 | | Comments | The DSGxxS phospho-dependent degron present in human Beta-catenin (CTNNB1) that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC), which recruits CTNNB1 to the SCF ubiquitin ligase complex |
Record No : 75 |
| Instance ID | 10835 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGQGS | | Bait Uniprot Accession | Q9HAW4 | | Bait Uniprot Identifier | CLSPN_HUMAN | | Bait Gene Name | CLSPN | | Sequence Position | 29-34 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP; Fluorescence-activated cell sorting | | Interaction ID | 20835 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16885022 | | Comments | The DSGxxS phospho-dependent degron in Human Claspin (CLSPN) that binds to the F-box/WD repeat-containing protein beta-TrCP (BTRC) for SCF-betaTrCP complex-mediated degradation of Claspin, which regulates recovery from the DNA replication checkpoint response |
Record No : 76 |
| Instance ID | 10856 | | Regular Expression | (Y)xNx | | Motif Instance | YGNV | | Bait Uniprot Accession | P15391 | | Bait Uniprot Identifier | CD19_HUMAN | | Bait Gene Name | CD19 | | Sequence Position | 348-351 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 20856 | | Interacting Domain | SH2 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 10706702 | | Comments | The SH2-domain of the human Adapter protein GRB2 binds to the human B-lymphocyte antigen CD19 at phosphorylated Y348 |
Record No : 77 |
| Instance ID | 10863 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YEDA | | Bait Uniprot Accession | Q60598 | | Bait Uniprot Identifier | SRC8_MOUSE | | Bait Gene Name | Cttn | | Sequence Position | 421-424 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Colocalization; SPR; Mutation analysis | | Interaction ID | 20863 | | Interacting Domain | SH2 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17606906 | | Comments | The mouse cytoplasmic adaptor protein Nck1 interacts with Src-phosphorylated cortactin (Cttn) via Tyr 421 to enhance actin assembly |
Record No : 78 |
| Instance ID | 10868 | | Regular Expression | (Y)[VLTFIC]xx | | Motif Instance | YVKM | | Bait Uniprot Accession | P09793 | | Bait Uniprot Identifier | CTLA4_MOUSE | | Bait Gene Name | Ctla4 | | Sequence Position | 201-204 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Peptide binding to perpetrator | | Interaction ID | 20868 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8638161 | | Comments | The phosphotyrosine (Y201) sequence within the cytoplasmic tail of mouse Cytotoxic T-lymphocyte-associated antigen 4 (Ctla4) mediates binding to the SH2 domain of mouse Protein-tyrosine phosphatase SYP (Ptpn11) suggesting that the RAS pathway and T cell activation through the T cell receptor are regulated by Ctla4-associated SYP |
Record No : 79 |
| Instance ID | 10906 | | Regular Expression | xxx[PV]xxP | | Motif Instance | SHRPPPP | | Bait Uniprot Accession | P06729 | | Bait Uniprot Identifier | CD2_HUMAN | | Bait Gene Name | CD2 | | Sequence Position | 294-300 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR; Competition binding | | Interaction ID | 20906 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12426371 | | Comments | Interaction of membrane-proximal proline-rich motif in the human T-cell surface antigen CD2 cytoplasmic tail with the SH3 domain of human Tyrosine-protein kinase FYN |
Record No : 80 |
| Instance ID | 10913 | | Regular Expression | PxxDY | | Motif Instance | PNPDY | | Bait Uniprot Accession | P07766 | | Bait Uniprot Identifier | CD3E_HUMAN | | Bait Gene Name | CD3E | | Sequence Position | 184-188 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Display technology; Co-IP; Mutation analysis | | Interaction ID | 20913 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17617578 | | Comments | The PxxDY motif of human T-cell surface glycoprotein CD3 epsilon (CD3E) mediates binding to the SH3 domain of human Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) |
Record No : 81 |
| Instance ID | 10914 | | Regular Expression | PxxDY | | Motif Instance | PNPDY | | Bait Uniprot Accession | P07766 | | Bait Uniprot Identifier | CD3E_HUMAN | | Bait Gene Name | CD3E | | Sequence Position | 184-188 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Display technology; Co-IP; Mutation analysis | | Interaction ID | 20914 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17617578 | | Comments | The PxxDY motif of human T-cell surface glycoprotein CD3 epsilon (CD3E) mediates binding to the N-terminal SH3 domain of human Cytoplasmic protein NCK1 |
Record No : 82 |
| Instance ID | 10915 | | Regular Expression | PxxDY | | Motif Instance | PNPDY | | Bait Uniprot Accession | P07766 | | Bait Uniprot Identifier | CD3E_HUMAN | | Bait Gene Name | CD3E | | Sequence Position | 184-188 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Display technology; Co-IP; Mutation analysis | | Interaction ID | 20915 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17617578 | | Comments | The PxxDY motif of human T-cell surface glycoprotein CD3 epsilon (CD3E) mediates binding to the N-terminal SH3 domain of human Cytoplasmic protein NCK2 |
Record No : 83 |
| Instance ID | 10920 | | Regular Expression | xPxAxVxP[^P] | | Motif Instance | KPAAVVAPI | | Bait Uniprot Accession | Q9HB71 | | Bait Uniprot Identifier | CYBP_HUMAN | | Bait Gene Name | CACYBP | | Sequence Position | 59-67 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Y2H; Co-IP | | Interaction ID | 20920 | | Interacting Domain | TRAF-like domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16085652, 11389839 | | Comments | The PxAxVxP motif in human Calcyclin-binding protein (CACYBP)/Siah-interacting protein that mediates binding to and degradation by human E3 ubiquitin-protein ligase SIAH1 |
Record No : 84 |
| Instance ID | 10956 | | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | | Motif Instance | VICIDD | | Bait Uniprot Accession | Q12873 | | Bait Uniprot Identifier | CHD3_HUMAN | | Bait Gene Name | CHD3 | | Sequence Position | 1995-2000 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Pull down | | Interaction ID | 20956 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21642969 | | Comments | The SUMO-interacting motif (SIM) of human ATP-dependent helicase CHD3 that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1) |
Record No : 85 |
| Instance ID | 10957 | | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | | Motif Instance | ILLDSD | | Bait Uniprot Accession | O00257 | | Bait Uniprot Identifier | CBX4_HUMAN | | Bait Gene Name | CBX4 | | Sequence Position | 463-468 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Mutation analysis; Y2H; Pull down(GST tag); Competition binding | | Interaction ID | 20957 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20176810 | | Comments | The SUMO E3 ligase activity of human E3 SUMO-protein ligase CBX4 is coordinated through a SUMO interaction motif (SIM) that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1) |
Record No : 86 |
| Instance ID | 10989 | | Regular Expression | ([KR][^ED]{0,5}[ST]xIP[^ED]{5,5})|([^ED]{5,5}[ST]xIP[^ED]{0,5}[KR]) | | Motif Instance | KRSKIPRSQGC | | Bait Uniprot Accession | O75122 | | Bait Uniprot Identifier | CLAP2_HUMAN | | Bait Gene Name | CLASP2 | | Sequence Position | 492-502 | | Critical Residues | P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Classical fluorescence spectroscopy | | Interaction ID | 20989 | | Interacting Domain | EBH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19632184 | | Comments | The C-terminal EBH domain of human End-binding protein 1 (EB1) or MAPRE1 binds to the SxIP motif (492-502) in the central part of human CLIP-associating protein 2 (CLASP2) |
Record No : 87 |
| Instance ID | 10990 | | Regular Expression | ([KR][^ED]{0,5}[ST]xIP[^ED]{5,5})|([^ED]{5,5}[ST]xIP[^ED]{0,5}[KR]) | | Motif Instance | RSSRIPRPSVS | | Bait Uniprot Accession | O75122 | | Bait Uniprot Identifier | CLAP2_HUMAN | | Bait Gene Name | CLASP2 | | Sequence Position | 515-525 | | Critical Residues | P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Classical fluorescence spectroscopy; Mutation analysis | | Interaction ID | 20990 | | Interacting Domain | EBH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19632184 | | Comments | The C-terminal EBH domain of human End-binding protein 1 (EB1) or MAPRE1 binds to the SxIP motif (515-525) in the central part of human CLIP-associating protein 2 (CLASP2) |
Record No : 88 |
| Instance ID | 11012 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | ERQSGDGQ | | Bait Uniprot Accession | O15234 | | Bait Uniprot Identifier | CASC3_HUMAN | | Bait Gene Name | CASC3 | | Sequence Position | 145-152 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 21012 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21478859 | | Comments | The Tankyrase-binding motif of human Cancer susceptibility candidate gene 3 protein (CASC3) that mediates its interaction with human ADP-ribosyltransferase Tankyrase-1 (TNKS) |
Record No : 89 |
| Instance ID | 11017 | | Regular Expression | [PSAT]x[QE]E | | Motif Instance | PVQE | | Bait Uniprot Accession | P25942 | | Bait Uniprot Identifier | TNR5_HUMAN | | Bait Gene Name | CD40 | | Sequence Position | 250-253 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography; Peptide Binding Assay | | Interaction ID | 21017 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10518213, 9718306 | | Comments | Human B-cell surface antigen CD40, a TNF receptor superfamily member, associates with the human TNF receptor-associated factor 2 (TRAF2) through a TRAF2 binding site in the CD40 cytoplasmic domain |
Record No : 90 |
| Instance ID | 11028 | | Regular Expression | xxPxExx[FYWHDE]x | | Motif Instance | QEPQEINFP | | Bait Uniprot Accession | P25942 | | Bait Uniprot Identifier | TNR5_HUMAN | | Bait Gene Name | CD40 | | Sequence Position | 231-239 | | Critical Residues | P3; P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Mutation analysis | | Interaction ID | 21028 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10318845 | | Comments | Human TNF receptor-associated factor 6 (TRAF6) interacts with the membrane-proximal TRAF6 binding site in human B-cell surface antigen CD40 |
Record No : 91 |
| Instance ID | 11070 | | Regular Expression | xxx([ST])Px | | Motif Instance | KATSPK | | Bait Uniprot Accession | Q8BT07 | | Bait Uniprot Identifier | CEP55_MOUSE | | Bait Gene Name | Cep55 | | Sequence Position | 420-425 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Alanine scanning; Phosphatase assay | | Interaction ID | 21070 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19638580 | | Comments | The mouse peptidyl-prolyl isomerase Pin1 regulates the final stages of cytokinesis by binding to the Ser-423-Pro motif of mouse Centrosomal protein of 55 kDa (Cep55), an essential component of the midbody ring |
Record No : 92 |
| Instance ID | 11080 | | Regular Expression | xxx([ST])Px | | Motif Instance | VEQTPK | | Bait Uniprot Accession | P46527 | | Bait Uniprot Identifier | CDN1B_HUMAN | | Bait Gene Name | CDKN1B | | Sequence Position | 184-189 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence technology; Co-IP; Mutation analysis | | Interaction ID | 21080 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19584057 | | Comments | The phosphorylation-dependent interaction between the WW domain of human Peptidyl-prolyl cis-trans isomerase PIN1 and Thr(187)-Pro motif in human Cyclin-dependent kinase inhibitor p27 (CDKN1B) catalyzes the cis-trans conformational changes of KIP1 and mediates its stability through the polyubiquitination mechanism |
Record No : 93 |
| Instance ID | 11081 | | Regular Expression | xxx([ST])Px | | Motif Instance | LACTPT | | Bait Uniprot Accession | P25322 | | Bait Uniprot Identifier | CCND1_MOUSE | | Bait Gene Name | Ccnd1 | | Sequence Position | 283-288 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 21081 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11805292 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 directly binds to mouse G1/S-specific cyclin-D1 phosphorylated on Thr-286-Pro, thereby positively regulating cyclin-D1 function at the transcriptional level |
Record No : 94 |
| Instance ID | 11082 | | Regular Expression | xxx([ST])Px | | Motif Instance | MLGSPV | | Bait Uniprot Accession | P35222 | | Bait Uniprot Identifier | CTNB1_HUMAN | | Bait Gene Name | CTNNB1 | | Sequence Position | 243-248 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Co-IP; Pull down; Alanine scanning | | Interaction ID | 21082 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11533658 | | Comments | The phosphorylation-dependent interaction between the WW domain of Mouse Peptidyl-prolyl cis-trans isomerase Pin1 and Ser-246-Pro motif in human Beta-catenin |
Record No : 95 |
| Instance ID | 11106 | | Regular Expression | xxx([ST])Px | | Motif Instance | SPKSPS | | Bait Uniprot Accession | Q8BT07 | | Bait Uniprot Identifier | CEP55_MOUSE | | Bait Gene Name | Cep55 | | Sequence Position | 423-428 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Alanine scanning; Pull down | | Interaction ID | 21106 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19638580 | | Comments | The mouse peptidyl-prolyl isomerase Pin1 regulates the final stages of cytokinesis by binding to the Ser-426-Pro motif of mouse Centrosomal protein of 55 kDa (Cep55), an essential component of the midbody ring |
Record No : 96 |
| Instance ID | 11108 | | Regular Expression | xxx([ST])Px | | Motif Instance | NRISPP | | Bait Uniprot Accession | Q61457 | | Bait Uniprot Identifier | CCNE1_MOUSE | | Bait Gene Name | Ccne1 | | Sequence Position | 382-387 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis; Pull down | | Interaction ID | 21108 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16223725 | | Comments | Prolyl isomerase Pin1 from Xenopus laevis interacts with the Ser-385-Pro motif of mouse G1/S-specific cyclin-E1 (Ccne1) |
Record No : 97 |
| Instance ID | 11144 | | Regular Expression | xxx([ST])Px | | Motif Instance | AYLSPP | | Bait Uniprot Accession | Q3U182 | | Bait Uniprot Identifier | CRTC2_MOUSE | | Bait Gene Name | Crtc2 | | Sequence Position | 133-138 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Co-IP; Alanine scanning | | Interaction ID | 21144 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20675384 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 associates with and induces translocation of mouse CREB-regulated transcription coactivator 2 (Crtc2) to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity |
Record No : 98 |
| Instance ID | 11165 | | Regular Expression | xx(T)xx[ILV]x | | Motif Instance | AYTLKVD | | Bait Uniprot Accession | Q9SYQ8 | | Bait Uniprot Identifier | CLV1_ARATH | | Bait Gene Name | CLV1 | | Sequence Position | 866-872 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Thr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR | | Interaction ID | 21165 | | Interacting Domain | FHA domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16042389 | | Comments | The FHA domain from the Arabidopsis receptor kinase-associated protein phosphatase (KAPP) binds to the phosphothreonine motif in its CLV1 receptor-like kinase partner |
Record No : 99 |
| Instance ID | 11179 | | Regular Expression | [QHR]x{0,1}P[PL]PP[GS]H[RH] | | Motif Instance | HPPPPPGHR | | Bait Uniprot Accession | P06729 | | Bait Uniprot Identifier | CD2_HUMAN | | Bait Gene Name | CD2 | | Sequence Position | 281-289 | | Critical Residues | P7; P8; P9 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Y2H; NMR; Mutation analysis | | Interaction ID | 21179 | | Interacting Domain | GYF domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12426371 | | Comments | The GYF domain of the human CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2) binds to a proline-rich sequence (281-289) in the cytoplasmic tail of human T-cell surface antigen CD2 |
Record No : 100 |
| Instance ID | 11180 | | Regular Expression | [QHR]x{0,1}P[PL]PP[GS]H[RH] | | Motif Instance | HRPPPPGHR | | Bait Uniprot Accession | P06729 | | Bait Uniprot Identifier | CD2_HUMAN | | Bait Gene Name | CD2 | | Sequence Position | 295-303 | | Critical Residues | P7; P8; P9 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Y2H; NMR; Mutation analysis | | Interaction ID | 21180 | | Interacting Domain | GYF domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12426371 | | Comments | The GYF domain of the human CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2) binds to a proline-rich sequence (295-303) in the cytoplasmic tail of human T-cell surface antigen CD2 |
Record No : 101 |
| Instance ID | 11228 | | Regular Expression | [ST]x[VL]D | | Motif Instance | SSVD | | Bait Uniprot Accession | Q9NQC7 | | Bait Uniprot Identifier | CYLD_HUMAN | | Bait Gene Name | CYLD | | Sequence Position | 361-364 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21228 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22876914 | | Comments | Novel internal motif identified in human Ubiquitin carboxyl-terminal hydrolase CYLD that is recognized by human Glutaminase-interacting protein (GIP), also known as Tax-interacting protein 1 (TIP1) or Tax1-binding protein 3 (TAX1BP3), composed almost exclusively of a single PDZ domain |
Record No : 102 |
| Instance ID | 11354 | | Regular Expression | PxAxVxP | | Motif Instance | PAAVVAP | | Bait Uniprot Accession | Q9HB71 | | Bait Uniprot Identifier | CYBP_HUMAN | | Bait Gene Name | CACYBP | | Sequence Position | 60-66 | | Critical Residues | P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Pull down(GST tag) | | Interaction ID | 21354 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11389839, 12626763 | | Comments | Peptide motif that mediates the interaction of SIP (a novel Siah-interacting protein) with SIAH1 |
Record No : 103 |
| Instance ID | 11355 | | Regular Expression | PxAxVxP | | Motif Instance | PAAVVAP | | Bait Uniprot Accession | Q9HB71 | | Bait Uniprot Identifier | CYBP_HUMAN | | Bait Gene Name | CACYBP | | Sequence Position | 60-66 | | Critical Residues | P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Pull down(GST tag) | | Interaction ID | 21355 | | Interacting Domain | Substrate-binding domain(SBD) of SINA/Siah proteins | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11389839, 12626763 | | Comments | Peptide motif that mediates the interaction of SIP (a novel Siah-interacting protein) with SIAH2 |
Record No : 104 |
| Instance ID | 11450 | | Regular Expression | LxxLL | | Motif Instance | LSELL | | Bait Uniprot Accession | P45481 | | Bait Uniprot Identifier | CBP_MOUSE | | Bait Gene Name | Crebbp | | Sequence Position | 69-73 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 21450 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8616895, 9192902 | | Comments | Conserved motif on N-terminal of CBP for interaction with the Retinoic acid receptor |
Record No : 105 |
| Instance ID | 11451 | | Regular Expression | LxxLL | | Motif Instance | LSELL | | Bait Uniprot Accession | P45481 | | Bait Uniprot Identifier | CBP_MOUSE | | Bait Gene Name | Crebbp | | Sequence Position | 69-73 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 21451 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8616895, 9192902 | | Comments | Conserved motif on N-terminal of CBP for interaction with the Thyroid hormone receptor |
Record No : 106 |
| Instance ID | 11452 | | Regular Expression | LxxLL | | Motif Instance | LSELL | | Bait Uniprot Accession | P45481 | | Bait Uniprot Identifier | CBP_MOUSE | | Bait Gene Name | Crebbp | | Sequence Position | 69-73 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 21452 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8616895, 9192902 | | Comments | Conserved motif on N-terminal of CBP for interaction with the Retinoid X receptor |
Record No : 107 |
| Instance ID | 11453 | | Regular Expression | LxxLL | | Motif Instance | LSELL | | Bait Uniprot Accession | P45481 | | Bait Uniprot Identifier | CBP_MOUSE | | Bait Gene Name | Crebbp | | Sequence Position | 69-73 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 21453 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8616895, 9192902 | | Comments | Conserved motif on N-terminal of CBP for interaction with the Estrogen receptor |
Record No : 108 |
| Instance ID | 11454 | | Regular Expression | LxxLL | | Motif Instance | LSELL | | Bait Uniprot Accession | P45481 | | Bait Uniprot Identifier | CBP_MOUSE | | Bait Gene Name | Crebbp | | Sequence Position | 69-73 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 21454 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8616895, 9192902 | | Comments | Conserved motif on N-terminal of CBP for interaction with the Glucocorticoid receptor |
Record No : 109 |
| Instance ID | 11455 | | Regular Expression | LxxLL | | Motif Instance | LVLLL | | Bait Uniprot Accession | P45481 | | Bait Uniprot Identifier | CBP_MOUSE | | Bait Gene Name | Crebbp | | Sequence Position | 357-361 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21455 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8616895, 9192902 | | Comments | Conserved motif on CBP for interaction with the Retinoic acid receptor |
Record No : 110 |
| Instance ID | 11456 | | Regular Expression | LxxLL | | Motif Instance | LVLLL | | Bait Uniprot Accession | P45481 | | Bait Uniprot Identifier | CBP_MOUSE | | Bait Gene Name | Crebbp | | Sequence Position | 357-361 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21456 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8616895, 9192902 | | Comments | Conserved motif on CBP for interaction with the Thyroid hormone receptor |
Record No : 111 |
| Instance ID | 11457 | | Regular Expression | LxxLL | | Motif Instance | LVLLL | | Bait Uniprot Accession | P45481 | | Bait Uniprot Identifier | CBP_MOUSE | | Bait Gene Name | Crebbp | | Sequence Position | 357-361 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21457 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8616895, 9192902 | | Comments | Conserved motif on CBP for interaction with the Retinoid X receptor |
Record No : 112 |
| Instance ID | 11458 | | Regular Expression | LxxLL | | Motif Instance | LVLLL | | Bait Uniprot Accession | P45481 | | Bait Uniprot Identifier | CBP_MOUSE | | Bait Gene Name | Crebbp | | Sequence Position | 357-361 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21458 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8616895, 9192902 | | Comments | Conserved motif on CBP for interaction with the the Glucocorticoid receptor |
Record No : 113 |
| Instance ID | 11459 | | Regular Expression | LxxLL | | Motif Instance | LVLLL | | Bait Uniprot Accession | P45481 | | Bait Uniprot Identifier | CBP_MOUSE | | Bait Gene Name | Crebbp | | Sequence Position | 357-361 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21459 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8616895, 9192902 | | Comments | Conserved motif on CBP for interaction with the Estrogen receptor |
Record No : 114 |
| Instance ID | 11468 | | Regular Expression | [RK]Sx[ST]xP | | Motif Instance | RSPSMP | | Bait Uniprot Accession | P30305 | | Bait Uniprot Identifier | MPIP2_HUMAN | | Bait Gene Name | CDC25B | | Sequence Position | 320-325 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21468 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8601312 | | Comments | 14-3-3 binding motif in CDC25B (pS-323) which binds 14-3-3 protein zeta |
Record No : 115 |
| Instance ID | 11491 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TDL | | Bait Uniprot Accession | Q02248 | | Bait Uniprot Identifier | CTNB1_MOUSE | | Bait Gene Name | Ctnnb1 | | Sequence Position | 779-781 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Y2H; Competition binding assay | | Interaction ID | 21491 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10772923, 15629897 | | Comments | The extreme C-terminus of Beta-catenin that contains the consensus sequence for binding the fifth PDZ domain of MAGI-1 |
Record No : 116 |
| Instance ID | 11567 | | Regular Expression | [ST]x[VLI]$ | | Motif Instance | TTL | | Bait Uniprot Accession | P27732 | | Bait Uniprot Identifier | CAC1D_RAT | | Bait Gene Name | Cacna1d | | Sequence Position | 2201-2203 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Y2H | | Interaction ID | 21567 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15689539 | | Comments | The C-terminal type I PDZ binding motif in rat Voltage-gated calcium channel subunit alpha Cav1.3 (Cacna1d) that mediates its specific interaction with the PDZ domain of rat Shank3 |
Record No : 117 |
| Instance ID | 11568 | | Regular Expression | [ST]x[VLI]$ | | Motif Instance | TTL | | Bait Uniprot Accession | P27732 | | Bait Uniprot Identifier | CAC1D_RAT | | Bait Gene Name | Cacna1d | | Sequence Position | 2201-2203 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21568 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15689539 | | Comments | The C-terminal type I PDZ binding motif in rat Voltage-gated calcium channel subunit alpha Cav1.3 (Cacna1d) that mediates its specific interaction with the PDZ domain of rat Shank1 |
Record No : 118 |
| Instance ID | 11569 | | Regular Expression | [ST]x[VLI]$ | | Motif Instance | SNL | | Bait Uniprot Accession | Q01815 | | Bait Uniprot Identifier | CAC1C_MOUSE | | Bait Gene Name | Cacna1c | | Sequence Position | 2137-2139 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21569 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10479680 | | Comments | PDZ domain binding C-terminal motif in the class C alpha1 subunit of a mouse brain calcium channel Cav1.2 (mbC alpha1) that mediates binding to the first PDZ domain of a large neuronal IL-16 precursor, NIL-16 |
Record No : 119 |
| Instance ID | 11592 | | Regular Expression | [DE]x[VLI]$ | | Motif Instance | DYV | | Bait Uniprot Accession | O95832 | | Bait Uniprot Identifier | CLD1_HUMAN | | Bait Gene Name | CLDN1 | | Sequence Position | 209-211 | | Critical Residues | P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21592 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12021270 | | Comments | Claudin-1 carboxyl terminus that interacts with the 8th PDZ domain of PATJ (INADL) |
Record No : 120 |
| Instance ID | 11593 | | Regular Expression | [DE]x[VLI]$ | | Motif Instance | DYV | | Bait Uniprot Accession | O88551 | | Bait Uniprot Identifier | CLD1_MOUSE | | Bait Gene Name | Cldn1 | | Sequence Position | 209-211 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag); Y2H | | Interaction ID | 21593 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11689568 | | Comments | Class III PDZ domain-binding motif of mouse claudin-1 that mediates binding to the PDZ10 of mouse Mupp1 (Mpdz) |
Record No : 121 |
| Instance ID | 11594 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | O88551 | | Bait Uniprot Identifier | CLD1_MOUSE | | Bait Gene Name | Cldn1 | | Sequence Position | 210-211 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21594 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346, 11689568 | | Comments | The COOH-terminal YV sequence of mouse Claudin-1 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-1 (Tjp1) |
Record No : 122 |
| Instance ID | 11595 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | O88551 | | Bait Uniprot Identifier | CLD1_MOUSE | | Bait Gene Name | Cldn1 | | Sequence Position | 210-211 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21595 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-1 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-2 (Tjp2) |
Record No : 123 |
| Instance ID | 11596 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | O88551 | | Bait Uniprot Identifier | CLD1_MOUSE | | Bait Gene Name | Cldn1 | | Sequence Position | 210-211 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21596 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-1 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-3 (Tjp3) |
Record No : 124 |
| Instance ID | 11597 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | O88552 | | Bait Uniprot Identifier | CLD2_MOUSE | | Bait Gene Name | Cldn2 | | Sequence Position | 229-230 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21597 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-2 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-1 (Tjp1) |
Record No : 125 |
| Instance ID | 11598 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | O88552 | | Bait Uniprot Identifier | CLD2_MOUSE | | Bait Gene Name | Cldn2 | | Sequence Position | 229-230 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21598 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-2 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-2 (Tjp2) |
Record No : 126 |
| Instance ID | 11599 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | O88552 | | Bait Uniprot Identifier | CLD2_MOUSE | | Bait Gene Name | Cldn2 | | Sequence Position | 229-230 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21599 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-2 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-3 (Tjp3) |
Record No : 127 |
| Instance ID | 11600 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | Q9Z0G9 | | Bait Uniprot Identifier | CLD3_MOUSE | | Bait Gene Name | Cldn3 | | Sequence Position | 218-219 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21600 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-3 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-1 (Tjp1) |
Record No : 128 |
| Instance ID | 11601 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | Q9Z0G9 | | Bait Uniprot Identifier | CLD3_MOUSE | | Bait Gene Name | Cldn3 | | Sequence Position | 218-219 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21601 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-3 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-2 (Tjp2) |
Record No : 129 |
| Instance ID | 11602 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | Q9Z0G9 | | Bait Uniprot Identifier | CLD3_MOUSE | | Bait Gene Name | Cldn3 | | Sequence Position | 218-219 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21602 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-3 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-3 (Tjp3) |
Record No : 130 |
| Instance ID | 11603 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | O35054 | | Bait Uniprot Identifier | CLD4_MOUSE | | Bait Gene Name | Cldn4 | | Sequence Position | 209-210 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21603 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-4 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-1 (Tjp1) |
Record No : 131 |
| Instance ID | 11604 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | O35054 | | Bait Uniprot Identifier | CLD4_MOUSE | | Bait Gene Name | Cldn4 | | Sequence Position | 209-210 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21604 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-4 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-2 (Tjp2) |
Record No : 132 |
| Instance ID | 11605 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | O35054 | | Bait Uniprot Identifier | CLD4_MOUSE | | Bait Gene Name | Cldn4 | | Sequence Position | 209-210 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21605 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-4 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-3 (Tjp3) |
Record No : 133 |
| Instance ID | 11606 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | O54942 | | Bait Uniprot Identifier | CLD5_MOUSE | | Bait Gene Name | Cldn5 | | Sequence Position | 217-218 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21606 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-5 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-1 (Tjp1) |
Record No : 134 |
| Instance ID | 11607 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | O54942 | | Bait Uniprot Identifier | CLD5_MOUSE | | Bait Gene Name | Cldn5 | | Sequence Position | 217-218 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21607 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-5 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-2 (Tjp2) |
Record No : 135 |
| Instance ID | 11608 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | O54942 | | Bait Uniprot Identifier | CLD5_MOUSE | | Bait Gene Name | Cldn5 | | Sequence Position | 217-218 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21608 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-5 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-3 (Tjp3) |
Record No : 136 |
| Instance ID | 11609 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | Q9Z262 | | Bait Uniprot Identifier | CLD6_MOUSE | | Bait Gene Name | Cldn6 | | Sequence Position | 218-219 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21609 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-6 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-1 (Tjp1) |
Record No : 137 |
| Instance ID | 11610 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | Q9Z262 | | Bait Uniprot Identifier | CLD6_MOUSE | | Bait Gene Name | Cldn6 | | Sequence Position | 218-219 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21610 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-6 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-2 (Tjp2) |
Record No : 138 |
| Instance ID | 11611 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | Q9Z262 | | Bait Uniprot Identifier | CLD6_MOUSE | | Bait Gene Name | Cldn6 | | Sequence Position | 218-219 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21611 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-6 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-3 (Tjp3) |
Record No : 139 |
| Instance ID | 11612 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | Q9Z261 | | Bait Uniprot Identifier | CLD7_MOUSE | | Bait Gene Name | Cldn7 | | Sequence Position | 210-211 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21612 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-7 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-1 (Tjp1) |
Record No : 140 |
| Instance ID | 11613 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | Q9Z261 | | Bait Uniprot Identifier | CLD7_MOUSE | | Bait Gene Name | Cldn7 | | Sequence Position | 210-211 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21613 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-7 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-2 (Tjp2) |
Record No : 141 |
| Instance ID | 11614 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | Q9Z261 | | Bait Uniprot Identifier | CLD7_MOUSE | | Bait Gene Name | Cldn7 | | Sequence Position | 210-211 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21614 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-7 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-3 (Tjp3) |
Record No : 142 |
| Instance ID | 11615 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | Q9Z260 | | Bait Uniprot Identifier | CLD8_MOUSE | | Bait Gene Name | Cldn8 | | Sequence Position | 224-225 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21615 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-8 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-1 (Tjp1) |
Record No : 143 |
| Instance ID | 11616 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | Q9Z260 | | Bait Uniprot Identifier | CLD8_MOUSE | | Bait Gene Name | Cldn8 | | Sequence Position | 224-225 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21616 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-8 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-2 (Tjp2) |
Record No : 144 |
| Instance ID | 11617 | | Regular Expression | YV$ | | Motif Instance | YV | | Bait Uniprot Accession | Q9Z260 | | Bait Uniprot Identifier | CLD8_MOUSE | | Bait Gene Name | Cldn8 | | Sequence Position | 224-225 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21617 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10601346 | | Comments | The COOH-terminal YV sequence of mouse Claudin-8 which mediates binding to the PDZ1 domain of mouse Tight junction protein ZO-3 (Tjp3) |
Record No : 145 |
| Instance ID | 11666 | | Regular Expression | [YFG][YFHW][WFA]$ | | Motif Instance | YFF | | Bait Uniprot Accession | Q9C0A0 | | Bait Uniprot Identifier | CNTP4_HUMAN | | Bait Gene Name | CNTNAP4 | | Sequence Position | 1306-1308 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; NMR; Fluorescence anisotropy binding assay | | Interaction ID | 21666 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20361982 | | Comments | Class II-type PDZ-binding motif in the C-terminal sequence of human Cell recognition molecule Caspr4 (CNTNAP4) that binds to the Tiam1 PDZ domain |
Record No : 146 |
| Instance ID | 11677 | | Regular Expression | YYKSLRR | | Motif Instance | YYKSLRR | | Bait Uniprot Accession | Q92496 | | Bait Uniprot Identifier | FHR4_HUMAN | | Bait Gene Name | CFHR4 | | Sequence Position | 35-41 | | Critical Residues | P1; P2; P3; P6; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Hypervariable loop | | Experimental Method(s) | Mutational analysis; Microtiter plate binding assay; Peptide array; Competition binding assay | | Interaction ID | 21677 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20042240, 19084272 | | Comments | C-reactive protein (CRP) binding motif found at the solvent-exposed hypervariable loop located between two beta-strands (denoted b2 and b3) of the first short consensus repeat (SCR1) domain surface of human complement factor H-related protein 4 (CFHR4) |
Record No : 147 |
| Instance ID | 11732 | | Regular Expression | PxxPxR | | Motif Instance | PPVPPR | | Bait Uniprot Accession | P22681 | | Bait Uniprot Identifier | CBL_HUMAN | | Bait Gene Name | CBL | | Sequence Position | 494-499 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Competition binding assay | | Interaction ID | 21732 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7592693, 7791764 | | Comments | The SH3 domain-binding PxxPxR motif in human proto-oncogene c-Cbl that binds the SH3 domains of human adapter protein GRB2 |
Record No : 148 |
| Instance ID | 11758 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RQLPQTP | | Bait Uniprot Accession | Q02294 | | Bait Uniprot Identifier | CAC1B_RAT | | Bait Gene Name | Cacna1b | | Sequence Position | 2185-2191 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21758 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11988172 | | Comments | The SH3 domain-binding motif in rat Voltage-gated calcium channel subunit alpha Cav2.2 (Cacna1b) that binds the SH3 domains of chicken RIMS-binding protein 2 (RBP2) |
Record No : 149 |
| Instance ID | 11759 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RLLPPTP | | Bait Uniprot Accession | O73700 | | Bait Uniprot Identifier | CAC1D_CHICK | | Bait Gene Name | CACNA1D | | Sequence Position | 1938-1944 | | Critical Residues | P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag); Y2H; Competition binding assay | | Interaction ID | 21759 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11988172 | | Comments | The SH3 domain-binding motif in chicken Voltage-gated calcium channel subunit alpha Cav1.3 (CACNA1D) that binds the SH3 domains of chicken RIMS-binding protein 2 (RBP2) |
Record No : 150 |
| Instance ID | 11760 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RLLPPTP | | Bait Uniprot Accession | O73700 | | Bait Uniprot Identifier | CAC1D_CHICK | | Bait Gene Name | CACNA1D | | Sequence Position | 1938-1944 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21760 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11988172 | | Comments | The SH3 domain-binding motif in chicken Voltage-gated calcium channel subunit alpha Cav1.3 (CACNA1D) that binds the SH3 domains of human RIMS-binding protein 1 (RBP1) |
Record No : 151 |
| Instance ID | 11761 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RLLPPTP | | Bait Uniprot Accession | O73700 | | Bait Uniprot Identifier | CAC1D_CHICK | | Bait Gene Name | CACNA1D | | Sequence Position | 1938-1944 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21761 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11988172 | | Comments | The SH3 domain-binding motif in chicken Voltage-gated calcium channel subunit alpha Cav1.3 (CACNA1D) that binds the SH3 domains of human RIMS-binding protein 2 (RBP2) |
Record No : 152 |
| Instance ID | 11770 | | Regular Expression | PxPxPR | | Motif Instance | PKPRPR | | Bait Uniprot Accession | Q13191 | | Bait Uniprot Identifier | CBLB_HUMAN | | Bait Gene Name | CBLB | | Sequence Position | 906-911 | | Critical Residues | P1; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography; Site-directed mutagenesis; ITC; Peptide binding assay; Competition binding assay | | Interaction ID | 21770 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286, 16228008 | | Comments | A novel polyproline-arginine motif (PXXXPR) in human E3 ubiquitin-protein ligase CBL-B specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85) |
Record No : 153 |
| Instance ID | 11771 | | Regular Expression | PxPxPR | | Motif Instance | PKPRPR | | Bait Uniprot Accession | Q13191 | | Bait Uniprot Identifier | CBLB_HUMAN | | Bait Gene Name | CBLB | | Sequence Position | 906-911 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21771 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286 | | Comments | A novel polyproline-arginine motif (PXXXPR) in human E3 ubiquitin-protein ligase CBL-B specifically recognized by the SH3 domains of CD2-associated protein (CMS/CD2AP) |
Record No : 154 |
| Instance ID | 11772 | | Regular Expression | PxPxPR | | Motif Instance | PKPRPR | | Bait Uniprot Accession | Q13191 | | Bait Uniprot Identifier | CBLB_HUMAN | | Bait Gene Name | CBLB | | Sequence Position | 906-911 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 21772 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286, 16228008 | | Comments | A novel polyproline-arginine motif (PXXXPR) in human E3 ubiquitin-protein ligase CBL-B specifically recognized by the SH3 domains of Rho guanine nucleotide exchange factor 7 (Beta-Pix) |
Record No : 155 |
| Instance ID | 11773 | | Regular Expression | PxPxPR | | Motif Instance | PKPFPR | | Bait Uniprot Accession | P22681 | | Bait Uniprot Identifier | CBL_HUMAN | | Bait Gene Name | CBL | | Sequence Position | 824-829 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; ITC; Peptide binding assay; Competition binding assay | | Interaction ID | 21773 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286, 16228008 | | Comments | A novel polyproline-arginine motif (PXXXPR) in human E3 ubiquitin-protein ligase CBL specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85) |
Record No : 156 |
| Instance ID | 11774 | | Regular Expression | PxPxPR | | Motif Instance | PKPFPR | | Bait Uniprot Accession | P22681 | | Bait Uniprot Identifier | CBL_HUMAN | | Bait Gene Name | CBL | | Sequence Position | 824-829 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21774 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286 | | Comments | A novel polyproline-arginine motif (PXXXPR) in human E3 ubiquitin-protein ligase CBL specifically recognized by the SH3 domains of CD2-associated protein (CMS/CD2AP) |
Record No : 157 |
| Instance ID | 11775 | | Regular Expression | PxPxPR | | Motif Instance | PLPRPR | | Bait Uniprot Accession | P06729 | | Bait Uniprot Identifier | CD2_HUMAN | | Bait Gene Name | CD2 | | Sequence Position | 327-332 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21775 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286, 11152963 | | Comments | A novel polyproline-arginine motif (PXXXPR) in human T-cell surface antigen CD2 that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA) |
Record No : 158 |
| Instance ID | 11776 | | Regular Expression | PxPxPR | | Motif Instance | PLPRPR | | Bait Uniprot Accession | P06729 | | Bait Uniprot Identifier | CD2_HUMAN | | Bait Gene Name | CD2 | | Sequence Position | 327-332 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; SPR | | Interaction ID | 21776 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9741631 | | Comments | A novel polyproline-arginine motif (PXXXPR) in human T-cell surface antigen CD2 that may be specifically recognized by the first SH3 Domain of CD2-associated protein (CMS/CD2AP) |
Record No : 159 |
| Instance ID | 11820 | | Regular Expression | Qxx[ILM]xx[FHY][FHY] | | Motif Instance | QTSMTDFY | | Bait Uniprot Accession | P38936 | | Bait Uniprot Identifier | CDN1A_HUMAN | | Bait Gene Name | CDKN1A | | Sequence Position | 144-151 | | Critical Residues | P1; P4; P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide pulldown; Peptide mapping; Mutational analysis | | Interaction ID | 21820 | | Interacting Domain | Unknown | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 7780738 | | Comments | An eight amino acid motif from the carboxyl terminus of the human cell-cycle regulator p21WAF1 (CDKN1A) that is required to bind the central loop of Proliferating cell nuclear antigen (PCNA) |
Record No : 160 |
| Instance ID | 11840 | | Regular Expression | PPGx[RK] | | Motif Instance | PPGHR | | Bait Uniprot Accession | P06729 | | Bait Uniprot Identifier | CD2_HUMAN | | Bait Gene Name | CD2 | | Sequence Position | 285-289 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Phage Display; SPOT Analysis; NMR Titration | | Interaction ID | 21840 | | Interacting Domain | GYF domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16000308 | | Comments | Proline-rich sequences (285-289) in human T-cell surface antigen CD2 that serves as a recognition motif for the GYF domain of the cellular adapter protein CD2BP2 |
Record No : 161 |
| Instance ID | 11841 | | Regular Expression | PPGx[RK] | | Motif Instance | PPGHR | | Bait Uniprot Accession | P06729 | | Bait Uniprot Identifier | CD2_HUMAN | | Bait Gene Name | CD2 | | Sequence Position | 299-303 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Phage Display; SPOT Analysis; NMR Titration | | Interaction ID | 21841 | | Interacting Domain | GYF domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16000308 | | Comments | Proline-rich sequences (299-303) in human T-cell surface antigen CD2 that serves as a recognition motif for the GYF domain of the cellular adapter protein CD2BP2 |
Record No : 162 |
| Instance ID | 11852 | | Regular Expression | FGPxL | | Motif Instance | FGPIL | | Bait Uniprot Accession | Q9UNU6 | | Bait Uniprot Identifier | CP8B1_HUMAN | | Bait Gene Name | CYP8B1 | | Sequence Position | 86-90 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Phage Display; SPOT Analysis | | Interaction ID | 21852 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15845542 | | Comments | The consensus motif in human Cytochrome P450 8B1 that represent putative target sites for binding of Cyclophilin A, a peptidyl-prolyl cis/trans-isomerase that is involved in multiple signaling events of eukaryotic cells |
Record No : 163 |
| Instance ID | 11862 | | Regular Expression | NxY[STEQ] | | Motif Instance | NNYQ | | Bait Uniprot Accession | P07333 | | Bait Uniprot Identifier | CSF1R_HUMAN | | Bait Gene Name | CSF1R | | Sequence Position | 967-970 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Tyr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Sequence based prediction | | Interaction ID | 21862 | | Interacting Domain | TKB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15737992, 11847211 | | Comments | Consensus sequence for phosphotyrosine recognition by the Cbl TKB domain in human Macrophage colony-stimulating factor 1 receptor (CSF1R) that promotes Cbl-dependent ubiquitination of CSF1R |
Record No : 164 |
| Instance ID | 11892 | | Regular Expression | YxxM | | Motif Instance | YVKM | | Bait Uniprot Accession | P16410 | | Bait Uniprot Identifier | CTLA4_HUMAN | | Bait Gene Name | CTLA4 | | Sequence Position | 201-204 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Mutational analysis; SPR | | Interaction ID | 21892 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11583591 | | Comments | The medium chain mu 2 subunit (AP50) of the clathrin-associated adapter protein complex 2 (AP-2) interacts specifically with Cytotoxic T-lymphocyte-associated antigen 4 through the consensus sequence YXXPhi (where X can be any residue and Phi is a large hydrophobic residue) |
Record No : 165 |
| Instance ID | 11929 | | Regular Expression | [DE][DE]x{1,2}[WF] | | Motif Instance | EDGNW | | Bait Uniprot Accession | P04040 | | Bait Uniprot Identifier | CATA_HUMAN | | Bait Gene Name | CAT | | Sequence Position | 139-143 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine-scanning mutagenesis; SPOT Analysis | | Interaction ID | 21929 | | Interacting Domain | Alpha M I domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12824186 | | Comments | A negatively charged peptide motif within the catalytic domain of Catalase that mediates binding to Integrin alpha-M of leukocytes |
Record No : 166 |
| Instance ID | 11930 | | Regular Expression | YEHI | | Motif Instance | YEHI | | Bait Uniprot Accession | P32927 | | Bait Uniprot Identifier | IL3RB_HUMAN | | Bait Gene Name | CSF2RB | | Sequence Position | 365-368 | | Critical Residues | P1; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine-scanning mutagenesis; Binding assay | | Interaction ID | 21930 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7957082 | | Comments | Residues in the Cytokine receptor common subunit beta that are essential for GM-CSF high affinity binding |
Record No : 167 |
| Instance ID | 11931 | | Regular Expression | YEHI | | Motif Instance | YEHI | | Bait Uniprot Accession | P32927 | | Bait Uniprot Identifier | IL3RB_HUMAN | | Bait Gene Name | CSF2RB | | Sequence Position | 365-368 | | Critical Residues | P1; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine-scanning mutagenesis; Binding assay | | Interaction ID | 21931 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7957082 | | Comments | Residues in the Cytokine receptor common subunit beta that are essential for IL-5 high affinity binding |
Record No : 168 |
| Instance ID | 11932 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | HSRSLP | | Bait Uniprot Accession | P32927 | | Bait Uniprot Identifier | IL3RB_HUMAN | | Bait Gene Name | CSF2RB | | Sequence Position | 598-603 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21932 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10477722 | | Comments | A phosphoserine motif in the cytoplasmic domain of Cytokine receptor common subunit beta that interacts with the adaptor protein 14-3-3 zeta |
Record No : 169 |
| Instance ID | 11948 | | Regular Expression | KTxxx[WI] | | Motif Instance | KTGHQI | | Bait Uniprot Accession | Q9EQC9 | | Bait Uniprot Identifier | CXXC4_RAT | | Bait Gene Name | Cxxc4 | | Sequence Position | 161-166 | | Critical Residues | P1; P2; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR | | Interaction ID | 21948 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer; Alzheimer's disease | | Inhibitor(s) | Unknown | | Reference(s) | 15313210 | | Comments | Minimum region of Idax required for binding to PDZ domain of Dishevelled |
Record No : 170 |
| Instance ID | 11976 | | Regular Expression | RxxL | | Motif Instance | RRPL | | Bait Uniprot Accession | P61024 | | Bait Uniprot Identifier | CKS1_HUMAN | | Bait Gene Name | CKS1B | | Sequence Position | 70-73 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21976 | | Interacting Domain | Unknown | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15014502 | | Comments | The minimal RxxL motif at the carboxy terminus of Cks1 that serves as a recognition site for APC/C activator protein Cdh1 and is thus required for Cdh1-mediated degradation of Cks1, which represents a principal mechanism to maintain the G1 state and to avoid premature entry into S phase, a potential cause of genetic instability |
Record No : 171 |
| Instance ID | 11996 | | Regular Expression | xxx([ST])Px | | Motif Instance | MLGSPV | | Bait Uniprot Accession | Q02248 | | Bait Uniprot Identifier | CTNB1_MOUSE | | Bait Gene Name | Ctnnb1 | | Sequence Position | 243-248 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 21996 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11533658 | | Comments | The phosphorylation-dependent interaction between the WW domain of Mouse Peptidyl-prolyl cis-trans isomerase Pin1 and Ser-246-Pro motif in mouse Beta-catenin (Ctnnb1) |
Record No : 172 |
| Instance ID | 12008 | | Regular Expression | LxHxTxxRPKx{6,6}P | | Motif Instance | LLHLTANRPKMPGRRLP | | Bait Uniprot Accession | Q9Y5K6 | | Bait Uniprot Identifier | CD2AP_HUMAN | | Bait Gene Name | CD2AP | | Sequence Position | 486-502 | | Critical Residues | P1; P8; P17 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; SPR | | Interaction ID | 22008 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16707503, 12690097 | | Comments | The motif present in human CD2-associated protein (CD2AP)/Adapter protein CMS that is sufficient for binding to human F-actin-capping protein subunit alpha-1 (CapZ alpha-1) |
Record No : 173 |
| Instance ID | 12009 | | Regular Expression | LxHxTxxRPKx{6,6}P | | Motif Instance | LLHLTANRPKMPGRRLP | | Bait Uniprot Accession | Q9Y5K6 | | Bait Uniprot Identifier | CD2AP_HUMAN | | Bait Gene Name | CD2AP | | Sequence Position | 486-502 | | Critical Residues | P1; P8; P17 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; SPR | | Interaction ID | 22009 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16707503, 12690097 | | Comments | The motif present in human CD2-associated protein (CD2AP)/Adapter protein CMS that is sufficient for binding to human F-actin-capping protein subunit alpha-2 (CapZ alpha-2) |
Record No : 174 |
| Instance ID | 12010 | | Regular Expression | LxHxTxxRPKx{6,6}P | | Motif Instance | LLHLTANRPKMPGRRLP | | Bait Uniprot Accession | Q9Y5K6 | | Bait Uniprot Identifier | CD2AP_HUMAN | | Bait Gene Name | CD2AP | | Sequence Position | 486-502 | | Critical Residues | P1; P8; P17 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; SPR | | Interaction ID | 22010 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16707503, 12690097 | | Comments | The motif present in human CD2-associated protein (CD2AP)/Adapter protein CMS that is sufficient for binding to human F-actin-capping protein subunit beta (CapZ beta) |
Record No : 175 |
| Instance ID | 12029 | | Regular Expression | x[DEKR]x[ACVILFM]$ | | Motif Instance | SCGF | | Bait Uniprot Accession | P0DML2 | | Bait Uniprot Identifier | CSH1_HUMAN | | Bait Gene Name | CSH1 | | Sequence Position | 214-217 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | ELISA; Pull down | | Interaction ID | 22029 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25009770 | | Comments | The carboxy-terminal PDZ binding motif of human Chorionic somatomammotropin hormone 1 (CSH1) that interacts with the human 26S proteasome non-ATPase regulatory subunit 9 (PSMD9) |
Record No : 176 |
| Instance ID | 12056 | | Regular Expression | [ILFVYM][ILFVYM]PPPPxxP | | Motif Instance | YIPPPPAEP | | Bait Uniprot Accession | Q8WXI2 | | Bait Uniprot Identifier | CNKR2_HUMAN | | Bait Gene Name | CNKSR2 | | Sequence Position | 352-360 | | Critical Residues | P3; P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22056 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24656827 | | Comments | Human CNK homolog protein 2 (CNK2)/ Connector enhancer of KSR 2 (CNKSR2) interacts with the N-terminal region of human Rho GTPase-activating protein 39 (ARHGAP39) through a short proline-rich WW domain-binding motif and thereby modulates Rac cycling during spine morphogenesis in hippocampal neurons |
Record No : 177 |
| Instance ID | 12073 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | HTSTTL | | Bait Uniprot Accession | P25025 | | Bait Uniprot Identifier | CXCR2_HUMAN | | Bait Gene Name | CXCR2 | | Sequence Position | 355-360 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22073 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 23544174 | | Comments | The C-terminal class 1 PDZ-binding motif in human C-X-C chemokine receptor type 2 (CXCR2) that binds to the PDZ domains of human Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) |
Record No : 178 |
| Instance ID | 12198 | | Regular Expression | EEVD | | Motif Instance | EEVD | | Bait Uniprot Accession | O00299 | | Bait Uniprot Identifier | CLIC1_HUMAN | | Bait Gene Name | CLIC1 | | Sequence Position | 150-153 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag); Competition binding | | Interaction ID | 22198 | | Interacting Domain | Ankyrin repeat-containing domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24338975 | | Comments | The EEVD sequence of Chloride intracellular channel protein 1 (CLIC1) that binds to the Ankyrin repeat-containing domain of human Gankyrin/ 26S proteasome non-ATPase regulatory subunit 10 (PSMD10) |
Record No : 179 |
| Instance ID | 12205 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TRV | | Bait Uniprot Accession | Q9Y5I7 | | Bait Uniprot Identifier | CLD16_HUMAN | | Bait Gene Name | CLDN16 | | Sequence Position | 303-305 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down; Co-IP | | Interaction ID | 22205 | | Interacting Domain | PDZ domain | | Disease Association(s) | Familial hypomagnesemia with hypercalciuria and ne | | Inhibitor(s) | Unknown | | Reference(s) | 14628289 | | Comments | C-terminal putative type 1 PDZ-binding motif in human renal tight junction protein Claudin-16 whose mutation abolishes binding to the human scaffolding protein ZO-1 resulting in its lysosomal mislocalization and is associated with childhood hypercalciuria |
Record No : 180 |
| Instance ID | 12213 | | Regular Expression | [SV][CY]GH[LIF][LAST][GAIV]x | | Motif Instance | SYGHISAT | | Bait Uniprot Accession | P19538 | | Bait Uniprot Identifier | CI_DROME | | Bait Gene Name | ci | | Sequence Position | 255-262 | | Critical Residues | P3; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; ITC | | Interaction ID | 22213 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9601642, 24217340 | | Comments | The motif in Gli transcription factor Cubitus interruptus (Ci) that mediates its interaction with Suppressor of fused homolog or Su(fu) in Drosophila |
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