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Total : 153 Records
Record No : 1 |
| Instance ID | 10134 | | Regular Expression | DP[FW] | | Motif Instance | DPW | | Bait Uniprot Accession | O88339 | | Bait Uniprot Identifier | EPN1_RAT | | Bait Gene Name | Epn1 | | Sequence Position | 349-351 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Classical fluorescence spectroscopy; Competition binding; Mutation analysis; Far Western blotting | | Interaction ID | 20134 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10380931, 10944104, 10692452 | | Comments | The DPF/W motif (349-351) of rat Epsin-1 that binds the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 2 |
| Instance ID | 10135 | | Regular Expression | DP[FW] | | Motif Instance | DPW | | Bait Uniprot Accession | O88339 | | Bait Uniprot Identifier | EPN1_RAT | | Bait Gene Name | Epn1 | | Sequence Position | 367-369 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Classical fluorescence spectroscopy; Mutation analysis; Far Western blotting; Competition binding | | Interaction ID | 20135 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10380931, 10944104, 10692452 | | Comments | The DPF/W motif (367-369) of rat Epsin-1 that binds the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 3 |
| Instance ID | 10136 | | Regular Expression | DP[FW] | | Motif Instance | DPW | | Bait Uniprot Accession | O88339 | | Bait Uniprot Identifier | EPN1_RAT | | Bait Gene Name | Epn1 | | Sequence Position | 274-276 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Mutation analysis; Far Western blotting; Competition binding; Classical fluorescence spectroscopy | | Interaction ID | 20136 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10380931, 10944104, 10692452 | | Comments | The DPF/W motif (274-276) of rat Epsin-1 that binds the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 4 |
| Instance ID | 10137 | | Regular Expression | DP[FW] | | Motif Instance | DPW | | Bait Uniprot Accession | O88339 | | Bait Uniprot Identifier | EPN1_RAT | | Bait Gene Name | Epn1 | | Sequence Position | 294-296 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Competition binding; Mutation analysis; Classical fluorescence spectroscopy; Far Western blotting | | Interaction ID | 20137 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10380931, 10944104, 10692452 | | Comments | The DPF/W motif (294-296) of rat Epsin-1 that binds the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 5 |
| Instance ID | 10138 | | Regular Expression | DP[FW] | | Motif Instance | DPW | | Bait Uniprot Accession | O88339 | | Bait Uniprot Identifier | EPN1_RAT | | Bait Gene Name | Epn1 | | Sequence Position | 306-308 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Mutation analysis; Classical fluorescence spectroscopy; Far Western blotting; Competition binding | | Interaction ID | 20138 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10380931, 10944104, 10692452 | | Comments | The DPF/W motif (306-308) of rat Epsin-1 that binds the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 6 |
| Instance ID | 10145 | | Regular Expression | DP[FW] | | Motif Instance | DPW | | Bait Uniprot Accession | O88339 | | Bait Uniprot Identifier | EPN1_RAT | | Bait Gene Name | Epn1 | | Sequence Position | 319-321 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Mutation analysis; Far Western blotting; Classical fluorescence spectroscopy; Competition binding | | Interaction ID | 20145 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10380931, 10944104, 10692452 | | Comments | The DPF/W motif (319-321) of rat Epsin-1 that binds the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 7 |
| Instance ID | 10146 | | Regular Expression | DP[FW] | | Motif Instance | DPW | | Bait Uniprot Accession | O88339 | | Bait Uniprot Identifier | EPN1_RAT | | Bait Gene Name | Epn1 | | Sequence Position | 332-334 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Classical fluorescence spectroscopy; Far Western blotting; Mutation analysis; Competition binding | | Interaction ID | 20146 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10380931, 10944104, 10692452 | | Comments | The DPF/W motif (332-334) of rat Epsin-1 that binds the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 8 |
| Instance ID | 10147 | | Regular Expression | DP[FW] | | Motif Instance | DPF | | Bait Uniprot Accession | P42567 | | Bait Uniprot Identifier | EPS15_MOUSE | | Bait Gene Name | Eps15 | | Sequence Position | 629-631 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20147 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12057195 | | Comments | The DPF motif peptide (629-631) of mouse Eps15 that binds the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 9 |
| Instance ID | 10148 | | Regular Expression | DP[FW] | | Motif Instance | DPW | | Bait Uniprot Accession | O88339 | | Bait Uniprot Identifier | EPN1_RAT | | Bait Gene Name | Epn1 | | Sequence Position | 377-379 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; Pull down; Classical fluorescence spectroscopy; Competition binding; Mutation analysis; Far Western blotting | | Interaction ID | 20148 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12057195, 10380931, 10944104, 10692452 | | Comments | The DPF/W motif (377-379) of rat Epsin-1 that binds the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 10 |
| Instance ID | 10149 | | Regular Expression | DP[FW] | | Motif Instance | DPF | | Bait Uniprot Accession | P42566 | | Bait Uniprot Identifier | EPS15_HUMAN | | Bait Gene Name | EPS15 | | Sequence Position | 672-674 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down; Mutation analysis | | Interaction ID | 20149 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10380931, 10944104, 8662627 | | Comments | Characteristic DPF repeat (672-674) in the COOH-terminal domain of human Eps15 binds specifically to the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 11 |
| Instance ID | 10150 | | Regular Expression | DP[FW] | | Motif Instance | DPF | | Bait Uniprot Accession | P42566 | | Bait Uniprot Identifier | EPS15_HUMAN | | Bait Gene Name | EPS15 | | Sequence Position | 692-694 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down; Mutation analysis | | Interaction ID | 20150 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10944104, 8662627 | | Comments | Characteristic DPF repeat (692-694) in the COOH-terminal domain of human Eps15 binds specifically to the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 12 |
| Instance ID | 10151 | | Regular Expression | DP[FW] | | Motif Instance | DPF | | Bait Uniprot Accession | P42566 | | Bait Uniprot Identifier | EPS15_HUMAN | | Bait Gene Name | EPS15 | | Sequence Position | 709-711 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis; Sequence based prediction | | Interaction ID | 20151 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8662627, 10380931, 10944104 | | Comments | Characteristic DPF repeat (709-711) in the COOH-terminal domain of human Eps15 binds specifically to the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 13 |
| Instance ID | 10152 | | Regular Expression | DP[FW] | | Motif Instance | DPF | | Bait Uniprot Accession | P42566 | | Bait Uniprot Identifier | EPS15_HUMAN | | Bait Gene Name | EPS15 | | Sequence Position | 737-739 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis; Sequence based prediction | | Interaction ID | 20152 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8662627, 10380931, 10944104 | | Comments | Characteristic DPF repeat (737-739) in the COOH-terminal domain of human Eps15 binds specifically to the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 14 |
| Instance ID | 10169 | | Regular Expression | xKENx | | Motif Instance | DKENE | | Bait Uniprot Accession | P03116 | | Bait Uniprot Identifier | VE1_BPV1 | | Bait Gene Name | E1 | | Sequence Position | 27-31 | | Critical Residues | P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20169 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14963168 | | Comments | KEN-box motif in the bovine papillomavirus E1 protein through which it is targeted for degradation by the anaphase-promoting complex (APC) by interaction with Cdh1 |
Record No : 15 |
| Instance ID | 10195 | | Regular Expression | [DE][DES][DEGAS]F[SGAD][DEAP][LVIMFD] | | Motif Instance | DDEFSEF | | Bait Uniprot Accession | P47160 | | Bait Uniprot Identifier | ENT3_YEAST | | Bait Gene Name | ENT3 | | Sequence Position | 269-275 | | Critical Residues | P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Radiolabel; Knock out; Y2H; Pull down; Co-IP; Colocalization; Classical fluorescence spectroscopy; Mutation analysis | | Interaction ID | 20195 | | Interacting Domain | Gamma adaptin ear (GAE) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12483220 | | Comments | The Gamma-ear interaction motif (269-275) of yeast Ent3p that interacts with gamma-ear domain of Gga2p |
Record No : 16 |
| Instance ID | 10197 | | Regular Expression | [DE][DES][DEGAS]F[SGAD][DEAP][LVIMFD] | | Motif Instance | DDEFGEM | | Bait Uniprot Accession | P47160 | | Bait Uniprot Identifier | ENT3_YEAST | | Bait Gene Name | ENT3 | | Sequence Position | 376-382 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis; Classical fluorescence spectroscopy; Colocalization; Co-IP; Pull down; Knock out; Radiolabel | | Interaction ID | 20197 | | Interacting Domain | Gamma adaptin ear (GAE) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12483220 | | Comments | The Gamma-ear interaction motif (376-382) of yeast Ent3p that interacts with gamma-ear domain of Gga2p |
Record No : 17 |
| Instance ID | 10199 | | Regular Expression | [DE][DES][DEGAS]F[SGAD][DEAP][LVIMFD] | | Motif Instance | DDEFDAD | | Bait Uniprot Accession | Q03769 | | Bait Uniprot Identifier | ENT5_YEAST | | Bait Gene Name | ENT5 | | Sequence Position | 219-225 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis; Classical fluorescence spectroscopy; Colocalization; Co-IP; Pull down; Knock out; Radiolabel | | Interaction ID | 20199 | | Interacting Domain | Gamma adaptin ear (GAE) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12483220 | | Comments | The Gamma-ear interaction motif (219-225) of yeast Ent5p that interacts with gamma-ear domain of Gga2p |
Record No : 18 |
| Instance ID | 10200 | | Regular Expression | [DE][DES][DEGAS]F[SGAD][DEAP][LVIMFD] | | Motif Instance | DDEFGDF | | Bait Uniprot Accession | Q03769 | | Bait Uniprot Identifier | ENT5_YEAST | | Bait Gene Name | ENT5 | | Sequence Position | 328-334 | | Critical Residues | P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Radiolabel; Knock out; Y2H; Pull down; Co-IP; Colocalization; Classical fluorescence spectroscopy; Mutation analysis | | Interaction ID | 20200 | | Interacting Domain | Gamma adaptin ear (GAE) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12483220 | | Comments | The Gamma-ear interaction motif (328-334) of yeast Ent5p that interacts with gamma-ear domain of Gga2p |
Record No : 19 |
| Instance ID | 10258 | | Regular Expression | [NQ]{0,1}xx[ILMV]T[DEN][HMFY][FMY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | NDITNYYKVKRRP | | Bait Uniprot Accession | Q27368 | | Bait Uniprot Identifier | E2F_DROME | | Bait Gene Name | E2f | | Sequence Position | 151-163 | | Critical Residues | P3; P6; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | RNA interference; Mutation disrupting interaction; Fluorescence-activated cell sorting; Co-IP; Alanine scanning | | Interaction ID | 20258 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19081076 | | Comments | S phase-specific destruction of Drosophila E2f1 is mediated by a PCNA-interacting-protein (PIP) motif in E2f1 |
Record No : 20 |
| Instance ID | 10282 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | PLNLS | | Bait Uniprot Accession | P41970 | | Bait Uniprot Identifier | ELK3_HUMAN | | Bait Gene Name | ELK3 | | Sequence Position | 273-277 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20282 | | Interacting Domain | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10369679 | | Comments | mCtBP1 interacts strongly with Net, a negative Ras-switchable ternary complex factor, through its CtBP interaction domain (CID) |
Record No : 21 |
| Instance ID | 10287 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RRLDL | | Bait Uniprot Accession | Q01094 | | Bait Uniprot Identifier | E2F1_HUMAN | | Bait Gene Name | E2F1 | | Sequence Position | 90-94 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; ITC; Pull down | | Interaction ID | 20287 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12501191, 9199321 | | Comments | The human transcription factor E2F-1 interacts stably with cyclin A via a cyclin recognition site (RxL motif) thus being negatively regulated by the cyclin A-dependent kinases |
Record No : 22 |
| Instance ID | 10300 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RRLF | | Bait Uniprot Accession | P06789 | | Bait Uniprot Identifier | VE1_HPV18 | | Bait Gene Name | E1 | | Sequence Position | 127-130 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Pull down; Mutation analysis | | Interaction ID | 20300 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9892642 | | Comments | The cyclin interaction motif (RXL motif) in the human papillomavirus (HPV) DNA replication initiation protein E1 that mediates its interaction with Cyclin E for phosphorylation by Cyclin E/Cdk2 Complex |
Record No : 23 |
| Instance ID | 10321 | | Regular Expression | xNPFx | | Motif Instance | SNPFL | | Bait Uniprot Accession | O88339 | | Bait Uniprot Identifier | EPN1_RAT | | Bait Gene Name | Epn1 | | Sequence Position | 500-504 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Far Western blotting; Co-IP; Pull down; Classical fluorescence spectroscopy | | Interaction ID | 20321 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9723620 | | Comments | EH domain-dependent interaction between rat Eps15 and Epsin-1 mediated by the NPF motif (500-504) in Epsin-1 |
Record No : 24 |
| Instance ID | 10332 | | Regular Expression | xNPFx | | Motif Instance | TNPFQ | | Bait Uniprot Accession | O88339 | | Bait Uniprot Identifier | EPN1_RAT | | Bait Gene Name | Epn1 | | Sequence Position | 516-520 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Far Western blotting; Pull down; Co-IP | | Interaction ID | 20332 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9723620 | | Comments | EH domain-dependent interaction between rat Eps15 and Epsin-1 mediated by the NPF motif (516-520) in Epsin-1 |
Record No : 25 |
| Instance ID | 10334 | | Regular Expression | xNPFx | | Motif Instance | TNPFL | | Bait Uniprot Accession | O88339 | | Bait Uniprot Identifier | EPN1_RAT | | Bait Gene Name | Epn1 | | Sequence Position | 570-574 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Far Western blotting; Pull down; Co-IP | | Interaction ID | 20334 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9723620 | | Comments | EH domain-dependent interaction between rat Eps15 and Epsin-1 mediated by the NPF motif (570-574) in Epsin-1 |
Record No : 26 |
| Instance ID | 10336 | | Regular Expression | xNPFx | | Motif Instance | SNPFL | | Bait Uniprot Accession | Q80VP1 | | Bait Uniprot Identifier | EPN1_MOUSE | | Bait Gene Name | Epn1 | | Sequence Position | 500-504 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 20336 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10064583 | | Comments | EH domain-dependent interaction between mouse Eps15 and Epsin-1 mediated by the NPF motif (500-504) in Epsin-1 |
Record No : 27 |
| Instance ID | 10337 | | Regular Expression | xNPFx | | Motif Instance | TNPFQ | | Bait Uniprot Accession | Q80VP1 | | Bait Uniprot Identifier | EPN1_MOUSE | | Bait Gene Name | Epn1 | | Sequence Position | 516-520 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 20337 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10064583 | | Comments | EH domain-dependent interaction between mouse Eps15 and Epsin-1 mediated by the NPF motif (516-520) in Epsin-1 |
Record No : 28 |
| Instance ID | 10338 | | Regular Expression | xNPFx | | Motif Instance | TNPFL | | Bait Uniprot Accession | Q80VP1 | | Bait Uniprot Identifier | EPN1_MOUSE | | Bait Gene Name | Epn1 | | Sequence Position | 570-574 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 20338 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10064583 | | Comments | EH domain-dependent interaction between mouse Eps15 and Epsin-1 mediated by the NPF motif (570-574) in Epsin-1 |
Record No : 29 |
| Instance ID | 10341 | | Regular Expression | xNPFx | | Motif Instance | LNPFL | | Bait Uniprot Accession | Q8CHU3 | | Bait Uniprot Identifier | EPN2_MOUSE | | Bait Gene Name | Epn2 | | Sequence Position | 493-497 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Y2H | | Interaction ID | 20341 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10336464, 10064583 | | Comments | Intersectin-1 interacts with mouse Ibp2 through its EH domain that binds the NPF motif (493-497) of Ibp2 |
Record No : 30 |
| Instance ID | 10343 | | Regular Expression | xNPFx | | Motif Instance | VNPFQ | | Bait Uniprot Accession | Q8CHU3 | | Bait Uniprot Identifier | EPN2_MOUSE | | Bait Gene Name | Epn2 | | Sequence Position | 507-511 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Y2H | | Interaction ID | 20343 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10336464, 10064583 | | Comments | Intersectin-1 interacts with mouse Ibp2 through its EH domain that binds the NPF motif (507-511) of Ibp2 |
Record No : 31 |
| Instance ID | 10344 | | Regular Expression | xNPFx | | Motif Instance | VNPFQ | | Bait Uniprot Accession | O95208 | | Bait Uniprot Identifier | EPN2_HUMAN | | Bait Gene Name | EPN2 | | Sequence Position | 551-555 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20344 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10567358 | | Comments | Asn-Pro-Phe motif (551-555) in human Epsin-2 that is responsible for the interaction with Eps15 homology (EH) domain of Epidermal growth factor receptor substrate 15 (EPS15) |
Record No : 32 |
| Instance ID | 10345 | | Regular Expression | xNPFx | | Motif Instance | TNPFL | | Bait Uniprot Accession | Q8CHU3 | | Bait Uniprot Identifier | EPN2_MOUSE | | Bait Gene Name | Epn2 | | Sequence Position | 590-594 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Pull down | | Interaction ID | 20345 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10064583, 10336464 | | Comments | Intersectin-1 interacts with mouse Ibp2 through its EH domain that binds the NPF motif (590-594) of Ibp2 |
Record No : 33 |
| Instance ID | 10376 | | Regular Expression | xNPFx | | Motif Instance | NNPFA | | Bait Uniprot Accession | Q12518 | | Bait Uniprot Identifier | ENT1_YEAST | | Bait Gene Name | ENT1 | | Sequence Position | 305-309 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Pull down | | Interaction ID | 20376 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12529323, 9531549 | | Comments | The yeast Epsin Ent1 NPF motif (305-309) interact with the EH domain-containing protein Pan1 |
Record No : 34 |
| Instance ID | 10377 | | Regular Expression | xNPFx | | Motif Instance | HNPFL | | Bait Uniprot Accession | Q12518 | | Bait Uniprot Identifier | ENT1_YEAST | | Bait Gene Name | ENT1 | | Sequence Position | 406-410 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis; Pull down | | Interaction ID | 20377 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12529323, 9531549 | | Comments | The yeast Epsin Ent1 NPF motif (406-410) interact with the EH domain-containing protein Pan1 |
Record No : 35 |
| Instance ID | 10378 | | Regular Expression | xNPFx | | Motif Instance | NNPFS | | Bait Uniprot Accession | Q05785 | | Bait Uniprot Identifier | ENT2_YEAST | | Bait Gene Name | ENT2 | | Sequence Position | 346-350 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20378 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9531549 | | Comments | The yeast Epsin Ent1 NPF motif (346-350) interact with the EH domain-containing protein Pan1 |
Record No : 36 |
| Instance ID | 10379 | | Regular Expression | xNPFx | | Motif Instance | NNPFL | | Bait Uniprot Accession | Q05785 | | Bait Uniprot Identifier | ENT2_YEAST | | Bait Gene Name | ENT2 | | Sequence Position | 490-494 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20379 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9531549 | | Comments | The yeast Epsin Ent1 NPF motif (490-494) interact with the EH domain-containing protein Pan1 |
Record No : 37 |
| Instance ID | 10382 | | Regular Expression | xNPFx | | Motif Instance | LNPFL | | Bait Uniprot Accession | O95208 | | Bait Uniprot Identifier | EPN2_HUMAN | | Bait Gene Name | EPN2 | | Sequence Position | 536-540 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20382 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10567358 | | Comments | Asn-Pro-Phe motif (536-540) in human Epsin-2 that is responsible for the interaction with Eps15 homology (EH) domain of Epidermal growth factor receptor substrate 15 (EPS15) |
Record No : 38 |
| Instance ID | 10383 | | Regular Expression | xNPFx | | Motif Instance | TNPFL | | Bait Uniprot Accession | O95208 | | Bait Uniprot Identifier | EPN2_HUMAN | | Bait Gene Name | EPN2 | | Sequence Position | 636-640 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20383 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10567358 | | Comments | Asn-Pro-Phe motif (636-640) in human Epsin-2 that is responsible for the interaction with Eps15 homology (EH) domain of Epidermal growth factor receptor substrate 15 (EPS15) |
Record No : 39 |
| Instance ID | 10386 | | Regular Expression | xNPFx | | Motif Instance | SNPFD | | Bait Uniprot Accession | Q8NDI1 | | Bait Uniprot Identifier | EHBP1_HUMAN | | Bait Gene Name | EHBP1 | | Sequence Position | 267-271 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20386 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14676205 | | Comments | Human EH domain protein 2 (EHD2) contains a C-terminal EH domain that interacts with the NPF repeat (267-271) in EHD2-binding protein 1 (EHBP1) and thereby links clathrin-mediated endocytosis to the actin cytoskeleton |
Record No : 40 |
| Instance ID | 10387 | | Regular Expression | xNPFx | | Motif Instance | LNPFG | | Bait Uniprot Accession | Q8NDI1 | | Bait Uniprot Identifier | EHBP1_HUMAN | | Bait Gene Name | EHBP1 | | Sequence Position | 278-282 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20387 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14676205 | | Comments | Human EH domain protein 2 (EHD2) contains a C-terminal EH domain that interacts with the NPF repeat (278-282) in EHD2-binding protein 1 (EHBP1) and thereby links clathrin-mediated endocytosis to the actin cytoskeleton |
Record No : 41 |
| Instance ID | 10388 | | Regular Expression | xNPFx | | Motif Instance | YNPFK | | Bait Uniprot Accession | Q8NDI1 | | Bait Uniprot Identifier | EHBP1_HUMAN | | Bait Gene Name | EHBP1 | | Sequence Position | 308-312 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20388 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14676205 | | Comments | Human EH domain protein 2 (EHD2) contains a C-terminal EH domain that interacts with the NPF repeat (308-312) in EHD2-binding protein 1 (EHBP1) and thereby links clathrin-mediated endocytosis to the actin cytoskeleton |
Record No : 42 |
| Instance ID | 10389 | | Regular Expression | xNPFx | | Motif Instance | LNPFD | | Bait Uniprot Accession | Q8NDI1 | | Bait Uniprot Identifier | EHBP1_HUMAN | | Bait Gene Name | EHBP1 | | Sequence Position | 320-324 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20389 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14676205 | | Comments | Human EH domain protein 2 (EHD2) contains a C-terminal EH domain that interacts with the NPF repeat (320-324) in EHD2-binding protein 1 (EHBP1) and thereby links clathrin-mediated endocytosis to the actin cytoskeleton |
Record No : 43 |
| Instance ID | 10390 | | Regular Expression | xNPFx | | Motif Instance | SNPFY | | Bait Uniprot Accession | Q8NDI1 | | Bait Uniprot Identifier | EHBP1_HUMAN | | Bait Gene Name | EHBP1 | | Sequence Position | 369-373 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20390 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14676205 | | Comments | Human EH domain protein 2 (EHD2) contains a C-terminal EH domain that interacts with the NPF repeat (369-373) in EHD2-binding protein 1 (EHBP1) and thereby links clathrin-mediated endocytosis to the actin cytoskeleton |
Record No : 44 |
| Instance ID | 10391 | | Regular Expression | xNPFx | | Motif Instance | SNPFL | | Bait Uniprot Accession | Q9Y6I3 | | Bait Uniprot Identifier | EPN1_HUMAN | | Bait Gene Name | EPN1 | | Sequence Position | 501-505 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Far Western blotting; Competition binding | | Interaction ID | 20391 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10557078 | | Comments | The EH domain of POB1 (or REPS2) interacts directly with the region containing the NPF motif (501-505) of Epsin |
Record No : 45 |
| Instance ID | 10392 | | Regular Expression | xNPFx | | Motif Instance | TNPFQ | | Bait Uniprot Accession | Q9Y6I3 | | Bait Uniprot Identifier | EPN1_HUMAN | | Bait Gene Name | EPN1 | | Sequence Position | 517-521 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Far Western blotting; Competition binding | | Interaction ID | 20392 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10557078 | | Comments | The EH domain of POB1 (or REPS2) interacts directly with the region containing the NPF motif (517-521) of Epsin |
Record No : 46 |
| Instance ID | 10393 | | Regular Expression | xNPFx | | Motif Instance | TNPFL | | Bait Uniprot Accession | Q9Y6I3 | | Bait Uniprot Identifier | EPN1_HUMAN | | Bait Gene Name | EPN1 | | Sequence Position | 571-575 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Far Western blotting; Competition binding | | Interaction ID | 20393 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10557078 | | Comments | The EH domain of POB1 (or REPS2) interacts directly with the region containing the NPF motif (571-575) of Epsin |
Record No : 47 |
| Instance ID | 10401 | | Regular Expression | x[FYH]x[IVM][^WFYP][^WFYP][ILM][ILMV]x | | Motif Instance | AFSISNILS | | Bait Uniprot Accession | P02836 | | Bait Uniprot Identifier | HMEN_DROME | | Bait Gene Name | en | | Sequence Position | 174-182 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20401 | | Interacting Domain | WD domain, G-beta repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8898227, 9367988 | | Comments | The eh1 motif in Drosophila Segmentation polarity homeobox protein engrailed (en) that binds to the WD40 domain of the Groucho corepressor |
Record No : 48 |
| Instance ID | 10411 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YDREQLL | | Bait Uniprot Accession | O61380 | | Bait Uniprot Identifier | O61380_DROME | | Bait Gene Name | eIF4G | | Sequence Position | 621-627 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20411 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10872469 | | Comments | YxxxxL motif in Drosophila Translation initiation factor eIF4G that mediate binding to the dorsal surface of eIF4E, a key regulator of eukaryotic cap-dependent translation, and play a role in translation initiation, via interactions with eIF4G |
Record No : 49 |
| Instance ID | 10413 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YDRKFLL | | Bait Uniprot Accession | O60516 | | Bait Uniprot Identifier | 4EBP3_HUMAN | | Bait Gene Name | EIF4EBP3 | | Sequence Position | 40-46 | | Critical Residues | P1; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20413 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10394359, 9593750 | | Comments | The eIF4E binding motif found in human 4E-BP3, a member of the family of Inhibitors of translation initiation known as eIF4E-binding proteins (4E-BPs), which competitively bind and sequester the available eIF4E thereby preventing eIF4F complex formation |
Record No : 50 |
| Instance ID | 10414 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YDRKFLL | | Bait Uniprot Accession | Q13542 | | Bait Uniprot Identifier | 4EBP2_HUMAN | | Bait Gene Name | EIF4EBP2 | | Sequence Position | 54-60 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Pull down; SPR | | Interaction ID | 20414 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10406811 | | Comments | The eIF4E binding motif found in human 4E-BP2, a member of the family of Inhibitors of translation initiation known as eIF4E-binding proteins (4E-BPs), which competitively bind and sequester the available eIF4E thereby preventing eIF4F complex formation |
Record No : 51 |
| Instance ID | 10415 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YDRKFLM | | Bait Uniprot Accession | Q13541 | | Bait Uniprot Identifier | 4EBP1_HUMAN | | Bait Gene Name | EIF4EBP1 | | Sequence Position | 54-60 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | ITC; X-ray crystallography; Mutation analysis; Colocalization; Y2H | | Interaction ID | 20415 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10394359, 10406811 | | Comments | The eIF4E binding motif found in human 4E-BP1, a member of the family of Inhibitors of translation initiation known as eIF4E-binding proteins (4E-BPs), which competitively bind and sequester the available eIF4E thereby preventing eIF4F complex formation |
Record No : 52 |
| Instance ID | 10418 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YDREFLL | | Bait Uniprot Accession | Q04637 | | Bait Uniprot Identifier | IF4G1_HUMAN | | Bait Gene Name | EIF4G1 | | Sequence Position | 612-618 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Far Western blotting | | Interaction ID | 20418 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7651417 | | Comments | The eIF4E binding motif found in human Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) or p220 that is critical for the interaction with EIF4E |
Record No : 53 |
| Instance ID | 10419 | | Regular Expression | YxxxxL[VILMF] | | Motif Instance | YDREFLL | | Bait Uniprot Accession | O43432 | | Bait Uniprot Identifier | IF4G3_HUMAN | | Bait Gene Name | EIF4G3 | | Sequence Position | 624-630 | | Critical Residues | P1; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | ITC; X-ray crystallography | | Interaction ID | 20419 | | Interacting Domain | Eukaryotic initiation factor 4E | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10394359 | | Comments | The eIF4E binding motif found in human Eukaryotic translation initiation factor 4 gamma 3 (EIF4G3) that is critical for the interaction with EIF4E |
Record No : 54 |
| Instance ID | 10456 | | Regular Expression | [DE]HxY | | Motif Instance | DHDY | | Bait Uniprot Accession | Q16254 | | Bait Uniprot Identifier | E2F4_HUMAN | | Bait Gene Name | E2F4 | | Sequence Position | 389-392 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20456 | | Interacting Domain | Galactose oxidase, central domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16633736 | | Comments | Transcription factor E2F4 specifically and directly interacts with human Host Cell Factor (HCF-1) via a consensus HCF-binding motif (HBM) present in E2F4, suggesting a linkage between E2F4 and HCF-1 cell growth pathways |
Record No : 55 |
| Instance ID | 10461 | | Regular Expression | [DE]HxY | | Motif Instance | DHLY | | Bait Uniprot Accession | P08152 | | Bait Uniprot Identifier | EGR2_MOUSE | | Bait Gene Name | Egr2 | | Sequence Position | 162-165 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20461 | | Interacting Domain | Galactose oxidase, central domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14532282 | | Comments | The HCF-binding motif in murine Zinc finger protein Krox-20 (Egr2) that binds to a six-bladed beta-propeller domain at the N terminus of HCF-1 |
Record No : 56 |
| Instance ID | 10464 | | Regular Expression | [DE]HxY | | Motif Instance | DHQY | | Bait Uniprot Accession | Q01094 | | Bait Uniprot Identifier | E2F1_HUMAN | | Bait Gene Name | E2F1 | | Sequence Position | 97-100 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis; Y2H | | Interaction ID | 20464 | | Interacting Domain | Galactose oxidase, central domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16633736, 17612494 | | Comments | The human G1 phase regulator HCF-1 displays coactivator properties when bound to the E2F1 transcriptional activator, but full-length E2F1 has regions that can inhibit its own interaction with the HCF-1 Kelch domain, suggesting that E2F1 has a latent ability to associate with HCF-1 |
Record No : 57 |
| Instance ID | 10526 | | Regular Expression | [KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF] | | Motif Instance | KGRKPRDLEL | | Bait Uniprot Accession | P19419 | | Bait Uniprot Identifier | ELK1_HUMAN | | Bait Gene Name | ELK1 | | Sequence Position | 312-321 | | Critical Residues | P8; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Protein Kinase Assay | | Interaction ID | 20526 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9925641 | | Comments | MAPK docking motif in human ETS domain-containing protein Elk-1 that mediates binding to mouse MAP kinase 1 (or ERK-2) |
Record No : 58 |
| Instance ID | 10527 | | Regular Expression | [KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF] | | Motif Instance | RSKKPKGLEL | | Bait Uniprot Accession | P28324 | | Bait Uniprot Identifier | ELK4_HUMAN | | Bait Gene Name | ELK4 | | Sequence Position | 318-327 | | Critical Residues | P8; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Protein Kinase Assay | | Interaction ID | 20527 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9925641, 11786537 | | Comments | MAPK docking motif in human ETS domain-containing protein Elk-4 (or SAP-1) that mediates binding to human MAP kinase 1 (or ERK-2) |
Record No : 59 |
| Instance ID | 10533 | | Regular Expression | [KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF] | | Motif Instance | KGKKPKGLEI | | Bait Uniprot Accession | P41971 | | Bait Uniprot Identifier | ELK3_MOUSE | | Bait Gene Name | Elk3 | | Sequence Position | 292-301 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 20533 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9925641 | | Comments | MAPK docking motif in mouse ETS domain-containing protein Elk-3 (Erp/Net) that mediates binding to mouse MAP kinase 1 (or ERK-2) |
Record No : 60 |
| Instance ID | 10538 | | Regular Expression | FxFP | | Motif Instance | FQFP | | Bait Uniprot Accession | P19419 | | Bait Uniprot Identifier | ELK1_HUMAN | | Bait Gene Name | ELK1 | | Sequence Position | 395-398 | | Critical Residues | P1; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20538 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11371562 | | Comments | The FXFP motif in human ETS domain-containing protein ELK1 that mediates binding to mouse MAP kinase 1 (or ERK-2) |
Record No : 61 |
| Instance ID | 10540 | | Regular Expression | FxFP | | Motif Instance | FQFP | | Bait Uniprot Accession | P28324 | | Bait Uniprot Identifier | ELK4_HUMAN | | Bait Gene Name | ELK4 | | Sequence Position | 398-401 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20540 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11029469 | | Comments | The FXFP motif in human ETS domain-containing protein ELK4 (or SAP1) that mediates binding to human MAP kinase 1 (or ERK-2) |
Record No : 62 |
| Instance ID | 10542 | | Regular Expression | PxLxP | | Motif Instance | PELSP | | Bait Uniprot Accession | P12978 | | Bait Uniprot Identifier | EBNA2_EBVB9 | | Bait Gene Name | EBNA2 | | Sequence Position | 383-387 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation disrupting interaction; Mutation analysis; Co-IP; Y2H | | Interaction ID | 20542 | | Interacting Domain | MYND domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11733528 | | Comments | The conserved Mynd domain of human protein BS69 (ZMYND11) binds the Epstein-Barr virus EBNA2 oncoprotein through a PxLxP motif (383-387) |
Record No : 63 |
| Instance ID | 10543 | | Regular Expression | PxLxP | | Motif Instance | PILFP | | Bait Uniprot Accession | P12978 | | Bait Uniprot Identifier | EBNA2_EBVB9 | | Bait Gene Name | EBNA2 | | Sequence Position | 437-441 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation disrupting interaction; Mutation analysis; Co-IP; Y2H | | Interaction ID | 20543 | | Interacting Domain | MYND domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11733528 | | Comments | The conserved Mynd domain of human protein BS69 (ZMYND11) binds the Epstein-Barr virus EBNA2 oncoprotein through a PxLxP motif (437-441) |
Record No : 64 |
| Instance ID | 10583 | | Regular Expression | [IL]A(P)x{6,8}[FLIVM]x[FLIVM] | | Motif Instance | LAPTPGDAIISLDF | | Bait Uniprot Accession | Q99814 | | Bait Uniprot Identifier | EPAS1_HUMAN | | Bait Gene Name | EPAS1 | | Sequence Position | 403-416 | | Critical Residues | P3 | | Motif PTM(s) | Hydroxylation at Pro-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20583 | | Interacting Domain | VHL beta domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 14691554, 17986458 | | Comments | Human Hypoxia-inducible factor 2-alpha (HIF2A)/ Endothelial PAS domain-containing protein 1 (EPAS1) is targeted for ubiquitylation by the pVHL complex by hydroxylation of Pro-405 to promote interaction with Von Hippel-Lindau disease tumor suppressor protein (VHL) |
Record No : 65 |
| Instance ID | 10584 | | Regular Expression | [IL]A(P)x{6,8}[FLIVM]x[FLIVM] | | Motif Instance | LAPYIPMDGEDFQL | | Bait Uniprot Accession | Q99814 | | Bait Uniprot Identifier | EPAS1_HUMAN | | Bait Gene Name | EPAS1 | | Sequence Position | 529-542 | | Critical Residues | P3 | | Motif PTM(s) | Hydroxylation at Pro-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20584 | | Interacting Domain | VHL beta domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 14691554, 17986458 | | Comments | Human Hypoxia-inducible factor 2-alpha (HIF2A)/ Endothelial PAS domain-containing protein 1 (EPAS1) is targeted for ubiquitylation by the pVHL complex by hydroxylation of Pro-531 to promote interaction with Von Hippel-Lindau disease tumor suppressor protein (VHL) |
Record No : 66 |
| Instance ID | 10594 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | STLNPDAPLFIPA | | Bait Uniprot Accession | Q39096 | | Bait Uniprot Identifier | ERD15_ARATH | | Bait Gene Name | ERD15 | | Sequence Position | 9-21 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20594 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15650869 | | Comments | The PABP-interacting motif 2 (PAM2) in Arabidopsis thaliana PAM2-containing protein CID1 (or ERD15) that mediates binding to the MLLE domain of Arabidopsis Polyadenylate-binding protein 2 (PAB2) |
Record No : 67 |
| Instance ID | 10619 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QLRIDSFFRL | | Bait Uniprot Accession | P28715 | | Bait Uniprot Identifier | ERCC5_HUMAN | | Bait Gene Name | ERCC5 | | Sequence Position | 990-999 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Competition binding assay; Pull down(GST tag) | | Interaction ID | 20619 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9305916 | | Comments | The PCNA binding PIP box motif in human DNA excision repair protein ERCC-5, a structure-specific endonuclease involved in DNA replication, that mediates its interaction with Proliferating cell nuclear antigen (PCNA) |
Record No : 68 |
| Instance ID | 10643 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | KIATLV | | Bait Uniprot Accession | P89079 | | Bait Uniprot Identifier | E4OR1_ADE09 | | Bait Gene Name | E4 | | Sequence Position | 120-125 | | Critical Residues | P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Co-IP; Mutation analysis | | Interaction ID | 20643 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11000240 | | Comments | PDZ domain-binding motif in the Ad9 E4-ORF1 oncoprotein that mediates binding to the PDZ7 and PDZ10 domains of rat Mupp1 (Mpdz) |
Record No : 69 |
| Instance ID | 10644 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | RRETQL | | Bait Uniprot Accession | P03126 | | Bait Uniprot Identifier | VE6_HPV16 | | Bait Gene Name | E6 | | Sequence Position | 153-158 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | NMR; SPR | | Interaction ID | 20644 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 21238461 | | Comments | C-terminal sequences in E6 oncoprotein of Human papillomavirus type 16 carrying the consensus PDZ-binding motif which binds to the second PDZ domain of MAGI-1 (MAGI-1 PDZ1) |
Record No : 70 |
| Instance ID | 10660 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | RRETQV | | Bait Uniprot Accession | P06463 | | Bait Uniprot Identifier | VE6_HPV18 | | Bait Gene Name | E6 | | Sequence Position | 153-158 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; ITC; NMR | | Interaction ID | 20660 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17267502, 17713926 | | Comments | C terminal binding motif of E6 oncoprotein of Human papillomavirus type 18 that binds to all three PDZ domains of DLG and causes a dramatic reduction in the levels of DLG expression by targeting it for proteasome mediated degradation |
Record No : 71 |
| Instance ID | 10676 | | Regular Expression | xxx[VLIFY]x[ACVILF]$ | | Motif Instance | EEGIWA | | Bait Uniprot Accession | Q811U3 | | Bait Uniprot Identifier | RB6I2_RAT | | Bait Gene Name | Erc1 | | Sequence Position | 943-948 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | ITC; NMR | | Interaction ID | 20676 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16095618 | | Comments | The C-terminal class 2 PDZ-binding motif of rat Elks (Erc1) that binds to the PDZ domain of rat Rim1 (Rims1) |
Record No : 72 |
| Instance ID | 10681 | | Regular Expression | xxx[VLIFY]x[ACVILF]$ | | Motif Instance | GLDVPV | | Bait Uniprot Accession | P04626 | | Bait Uniprot Identifier | ERBB2_HUMAN | | Bait Gene Name | ERBB2 | | Sequence Position | 1250-1255 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | ITC; X-ray crystallography | | Interaction ID | 20681 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12444095 | | Comments | The C-terminal class 2 PDZ-binding motif of the human receptor tyrosine kinase ErbB2 (ERBB2) that binds to the PDZ domain of human ERBIN/LAP2 (ERBB2IP) |
Record No : 73 |
| Instance ID | 10762 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | SVQNPVY | | Bait Uniprot Accession | P00533 | | Bait Uniprot Identifier | EGFR_HUMAN | | Bait Gene Name | EGFR | | Sequence Position | 1104-1110 | | Critical Residues | P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Y2H; Mutation analysis; Pull down | | Interaction ID | 20762 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15476828 | | Comments | Phosphotyrosine binding (PTB) domains of the Human adaptor protein DOK1 specifically associates with the tyrosine-phosphorylated NPxY motif (1104-1110) of human Epidermal growth factor receptor (EGFR) |
Record No : 74 |
| Instance ID | 10772 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | SLDNPDY | | Bait Uniprot Accession | P00533 | | Bait Uniprot Identifier | EGFR_HUMAN | | Bait Gene Name | EGFR | | Sequence Position | 1166-1172 | | Critical Residues | P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Y2H; Mutation analysis; Pull down | | Interaction ID | 20772 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15476828 | | Comments | Phosphotyrosine binding (PTB) domains of the Human adaptor protein DOK1 specifically associates with the tyrosine-phosphorylated NPxY motif (1166-1172) of human Epidermal growth factor receptor (EGFR) |
Record No : 75 |
| Instance ID | 10773 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | AFDNPDY | | Bait Uniprot Accession | P21860 | | Bait Uniprot Identifier | ERBB3_HUMAN | | Bait Gene Name | ERBB3 | | Sequence Position | 1322-1328 | | Critical Residues | P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Co-IP; Protein kinase assay; Mutation analysis | | Interaction ID | 20773 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8026468 | | Comments | The phosphotyrosine-binding (PTB) domain of human SHC-transforming protein 1 (SHC1) interacts with the tyrosine-phosphorylated NPxY motif of human Proto-oncogene-like protein c-ErbB-3 (ERBB3) |
Record No : 76 |
| Instance ID | 10774 | | Regular Expression | F[EDQS][MILV][ED][MILV]((x{0,1}[ED])|($)) | | Motif Instance | FEMDI | | Bait Uniprot Accession | Q13541 | | Bait Uniprot Identifier | 4EBP1_HUMAN | | Bait Gene Name | EIF4EBP1 | | Sequence Position | 114-118 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Western blot; Pull down; Mutation analysis | | Interaction ID | 20774 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12912989 | | Comments | The TOS motif in human translational repressor protein EIF4EBP1 (4E-BP1, also termed PHAS-I) acts as a docking site for the human TOR pathway adaptor protein RAPTOR |
Record No : 77 |
| Instance ID | 10778 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LGCDE | | Bait Uniprot Accession | Q9Y6B2 | | Bait Uniprot Identifier | EID1_HUMAN | | Bait Gene Name | EID1 | | Sequence Position | 178-182 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20778 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11073990 | | Comments | The Rb-binding LxCxE motif in the Human E1A-like inhibitor of differentiation 1 (EID-1) that mediates binding to a highly conserved shallow groove in the B domain of the human retinoblastoma protein (RB) |
Record No : 78 |
| Instance ID | 10781 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LYCYE | | Bait Uniprot Accession | P03129 | | Bait Uniprot Identifier | VE7_HPV16 | | Bait Gene Name | E7 | | Sequence Position | 22-26 | | Critical Residues | P1; P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20781 | | Interacting Domain | B domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 9495340 | | Comments | The Rb-binding LxCxE motif in the human papilloma virus E7 oncoprotein that mediates binding to a highly conserved shallow groove in the B domain of the human retinoblastoma protein (RB) |
Record No : 79 |
| Instance ID | 10789 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LACVE | | Bait Uniprot Accession | P32519 | | Bait Uniprot Identifier | ELF1_HUMAN | | Bait Gene Name | ELF1 | | Sequence Position | 51-55 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20789 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8493578 | | Comments | The Rb-binding LxCxE motif in the Human ETS-related transcription factor ELF1 that mediates binding to the human retinoblastoma protein (RB) |
Record No : 80 |
| Instance ID | 10807 | | Regular Expression | xx[LIMV]xx[LM][FY]Dx | | Motif Instance | EGIRDLFDC | | Bait Uniprot Accession | Q01094 | | Bait Uniprot Identifier | E2F1_HUMAN | | Bait Gene Name | E2F1 | | Sequence Position | 419-427 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Pull down(GST tag); Competition binding | | Interaction ID | 20807 | | Interacting Domain | Rb pocket AB groove | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8346196, 8413249 | | Comments | Human RB suppresses Transcription factor E2F1-mediated transcriptional activation through direct physical association via the LxxLFD retinoblastoma (RB)-binding sequence |
Record No : 81 |
| Instance ID | 10808 | | Regular Expression | xx[LIMV]xx[LM][FY]Dx | | Motif Instance | EGISDLFDS | | Bait Uniprot Accession | Q14209 | | Bait Uniprot Identifier | E2F2_HUMAN | | Bait Gene Name | E2F2 | | Sequence Position | 420-428 | | Critical Residues | P1; P2; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | 3(10)-helix | | Experimental Method(s) | X-ray crystallography; Mutation analysis; ITC | | Interaction ID | 20808 | | Interacting Domain | Rb pocket AB groove | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12502741 | | Comments | Human RB suppresses Transcription factor E2F2-mediated transcriptional activation through direct physical association via the LxxLFD retinoblastoma (RB)-binding sequence |
Record No : 82 |
| Instance ID | 10849 | | Regular Expression | (Y)xNx | | Motif Instance | YVNQ | | Bait Uniprot Accession | P04626 | | Bait Uniprot Identifier | ERBB2_HUMAN | | Bait Gene Name | ERBB2 | | Sequence Position | 1139-1142 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Beta turn | | Experimental Method(s) | NMR | | Interaction ID | 20849 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12975581, 11500516 | | Comments | Phosphorylation of Tyr-1139 in the Human Receptor tyrosine-protein kinase erbB-2 (ERBB2) creates a docking site for the SH2-domain of the human adapter protein Growth factor receptor-bound protein 7 (GRB7) |
Record No : 83 |
| Instance ID | 10869 | | Regular Expression | (Y)[VLTFIC]xx | | Motif Instance | YTPM | | Bait Uniprot Accession | Q15303 | | Bait Uniprot Identifier | ERBB4_HUMAN | | Bait Gene Name | ERBB4 | | Sequence Position | 1056-1059 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Protein array; Co-IP; Competition binding | | Interaction ID | 20869 | | Interacting Domain | SH2 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18721752, 8617750, 10353604 | | Comments | Tyrosine-phosphorylated (Y1056) Human Proto-oncogene-like protein c-ErbB-4 binds to the N- and C-terminal SH2 domains of Human PI3K regulatory subunit alpha (PIK3R1) |
Record No : 84 |
| Instance ID | 10973 | | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | | Motif Instance | IILSDSEEEE | | Bait Uniprot Accession | Q06265 | | Bait Uniprot Identifier | EXOS9_HUMAN | | Bait Gene Name | EXOSC9 | | Sequence Position | 389-398 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Alanine scanning | | Interaction ID | 20973 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10961991 | | Comments | The SUMO-interacting motif (SIM) of human Exosome component 9 (EXOSC9) that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1) |
Record No : 85 |
| Instance ID | 11048 | | Regular Expression | PxE[^P]xS[^P] | | Motif Instance | PGEGPST | | Bait Uniprot Accession | P03211 | | Bait Uniprot Identifier | EBNA1_EBVB9 | | Bait Gene Name | EBNA1 | | Sequence Position | 442-448 | | Critical Residues | P3; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis; Classical fluorescence spectroscopy; X-ray crystallography | | Interaction ID | 21048 | | Interacting Domain | MATH domain | | Disease Association(s) | Epstein-Barr Virus (EBV) infection | | Inhibitor(s) | Unknown | | Reference(s) | 15808506 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 (also known as HAUSP) binds to a P/AXXS motif in the Epstein-Barr nuclear antigen 1 (EBNA1) protein of Epstein-Barr virus (EBV) and may contribute to the survival of Epstein-Barr virus-infected cells |
Record No : 86 |
| Instance ID | 11059 | | Regular Expression | PPxY | | Motif Instance | PPAY | | Bait Uniprot Accession | Q15303 | | Bait Uniprot Identifier | ERBB4_HUMAN | | Bait Gene Name | ERBB4 | | Sequence Position | 1053-1056 | | Critical Residues | P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Confocal microscopy; Pull down; Mutation analysis | | Interaction ID | 21059 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18334649 | | Comments | The PPXY motif within the CYT-1 isoforms of human Receptor tyrosine-protein kinase ERBB4 provides a binding site for human WW domain-containing E3 ubiquitin-protein ligase ITCH and is necessary both for ubiquitination and endocytosis of CYT-1 isoforms |
Record No : 87 |
| Instance ID | 11200 | | Regular Expression | PPLP | | Motif Instance | PPLP | | Bait Uniprot Accession | Q03173 | | Bait Uniprot Identifier | ENAH_MOUSE | | Bait Gene Name | Enah | | Sequence Position | 602-605 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Peptide array; Far Western blotting; Co-IP; Pull down(GST tag); Competition binding | | Interaction ID | 21200 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9407065 | | Comments | The PPLP motif in mouse Mena (Enah), the mammalian homolog of Drosophila Enabled, that is recognized by the group II WW domain of mouse neural protein Fe65 (Apbb1) |
Record No : 88 |
| Instance ID | 11223 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYRHRNTV | | Bait Uniprot Accession | Q15303 | | Bait Uniprot Identifier | ERBB4_HUMAN | | Bait Gene Name | ERBB4 | | Sequence Position | 1298-1307 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21223 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Human E3 ubiquitin-protein ligase ITCH, a group I WW domain protein, and human Proto-oncogene-like protein c-ErbB-4 (ERBB4) may interact with each other through the WW2 domain and the consensus PPxY or PY motif |
Record No : 89 |
| Instance ID | 11224 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYRHRNTV | | Bait Uniprot Accession | Q62956 | | Bait Uniprot Identifier | ERBB4_RAT | | Bait Gene Name | Erbb4 | | Sequence Position | 1298-1307 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21224 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Rat E3 ubiquitin-protein ligase Itch, a group I WW domain protein, and rat Proto-oncogene-like protein c-ErbB-4 (Erbb4) may interact with each other through the WW2 domain and the consensus PPxY or PY motif |
Record No : 90 |
| Instance ID | 11225 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYRHRNTV | | Bait Uniprot Accession | Q61527 | | Bait Uniprot Identifier | ERBB4_MOUSE | | Bait Gene Name | Erbb4 | | Sequence Position | 1298-1307 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21225 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Mouse E3 ubiquitin-protein ligase Itch, a group I WW domain protein, and mouse Proto-oncogene-like protein c-ErbB-4 (Erbb4) may interact with each other through the WW2 domain and the consensus PPxY or PY motif |
Record No : 91 |
| Instance ID | 11236 | | Regular Expression | xGxxPG | | Motif Instance | PGAIPG | | Bait Uniprot Accession | P15502 | | Bait Uniprot Identifier | ELN_HUMAN | | Bait Gene Name | ELN | | Sequence Position | 30-35 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Type VIII reverse beta-turn | | Experimental Method(s) | Sequence based prediction; Chemotaxis assay; Gelatin zymography; ELISA | | Interaction ID | 21236 | | Interacting Domain | Elastin-binding domain of EBP | | Disease Association(s) | Emphysema; Aneurysm; Cancer | | Inhibitor(s) | Galactosugars | | Reference(s) | 8388074, 8396888, 15148686, 11084020, 1848864, 8034752, 2550450, 11723829 | | Comments | The 67-kD human elastin-binding protein (EBP) binds to a chemokinetic hexapeptide (30-35) from human Tropoelastin and mediates cell adhesion to elastin and elastin fiber assembly |
Record No : 92 |
| Instance ID | 11237 | | Regular Expression | xGxxPG | | Motif Instance | PGAIPG | | Bait Uniprot Accession | P15502 | | Bait Uniprot Identifier | ELN_HUMAN | | Bait Gene Name | ELN | | Sequence Position | 286-291 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Type VIII reverse beta-turn | | Experimental Method(s) | Sequence based prediction; Chemotaxis assay; Gelatin zymography; ELISA | | Interaction ID | 21237 | | Interacting Domain | Elastin-binding domain of EBP | | Disease Association(s) | Emphysema; Aneurysm; Cancer | | Inhibitor(s) | Galactosugars | | Reference(s) | 8388074, 8396888, 15148686, 11084020, 1848864, 8034752, 2550450, 11723829 | | Comments | The 67-kD human elastin-binding protein (EBP) binds to a chemokinetic hexapeptide (286-291) from human Tropoelastin and mediates cell adhesion to elastin and elastin fiber assembly |
Record No : 93 |
| Instance ID | 11238 | | Regular Expression | xGxxPG | | Motif Instance | VGVAPG | | Bait Uniprot Accession | P15502 | | Bait Uniprot Identifier | ELN_HUMAN | | Bait Gene Name | ELN | | Sequence Position | 506-511 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Type VIII reverse beta-turn | | Experimental Method(s) | NMR; CD; Fluorimetric measurements | | Interaction ID | 21238 | | Interacting Domain | Elastin-binding domain of EBP | | Disease Association(s) | Emphysema; Aneurysm; Cancer | | Inhibitor(s) | Galactosugars | | Reference(s) | 15148686, 19241470, 23166321, 1848864, 8034752, 2550450 | | Comments | The 67-kD human elastin-binding protein (EBP) binds to a chemokinetic hexapeptide (506-511) from human Tropoelastin and mediates cell adhesion to elastin and elastin fiber assembly |
Record No : 94 |
| Instance ID | 11239 | | Regular Expression | xGxxPG | | Motif Instance | VGVAPG | | Bait Uniprot Accession | P15502 | | Bait Uniprot Identifier | ELN_HUMAN | | Bait Gene Name | ELN | | Sequence Position | 512-517 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Type VIII reverse beta-turn | | Experimental Method(s) | NMR; CD; Fluorimetric measurements | | Interaction ID | 21239 | | Interacting Domain | Elastin-binding domain of EBP | | Disease Association(s) | Emphysema; Aneurysm; Cancer | | Inhibitor(s) | Galactosugars | | Reference(s) | 15148686, 19241470, 23166321, 1848864, 8034752, 2550450 | | Comments | The 67-kD human elastin-binding protein (EBP) binds to a chemokinetic hexapeptide (512-517) from human Tropoelastin and mediates cell adhesion to elastin and elastin fiber assembly |
Record No : 95 |
| Instance ID | 11240 | | Regular Expression | xGxxPG | | Motif Instance | VGVAPG | | Bait Uniprot Accession | P15502 | | Bait Uniprot Identifier | ELN_HUMAN | | Bait Gene Name | ELN | | Sequence Position | 518-523 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Type VIII reverse beta-turn | | Experimental Method(s) | NMR; CD; Fluorimetric measurements | | Interaction ID | 21240 | | Interacting Domain | Elastin-binding domain of EBP | | Disease Association(s) | Emphysema; Aneurysm; Cancer | | Inhibitor(s) | Galactosugars | | Reference(s) | 15148686, 19241470, 23166321, 1848864, 8034752, 2550450 | | Comments | The 67-kD human elastin-binding protein (EBP) binds to a chemokinetic hexapeptide (518-523) from human Tropoelastin and mediates cell adhesion to elastin and elastin fiber assembly |
Record No : 96 |
| Instance ID | 11241 | | Regular Expression | xGxxPG | | Motif Instance | VGVAPG | | Bait Uniprot Accession | P15502 | | Bait Uniprot Identifier | ELN_HUMAN | | Bait Gene Name | ELN | | Sequence Position | 542-547 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Type VIII reverse beta-turn | | Experimental Method(s) | NMR; CD; Fluorimetric measurements | | Interaction ID | 21241 | | Interacting Domain | Elastin-binding domain of EBP | | Disease Association(s) | Emphysema; Aneurysm; Cancer | | Inhibitor(s) | Galactosugars | | Reference(s) | 15148686, 19241470, 23166321, 1848864, 8034752, 2550450 | | Comments | The 67-kD human elastin-binding protein (EBP) binds to a chemokinetic hexapeptide (542-547) from human Tropoelastin and mediates cell adhesion to elastin and elastin fiber assembly |
Record No : 97 |
| Instance ID | 11284 | | Regular Expression | [KR]xTQTx | | Motif Instance | KQTQTP | | Bait Uniprot Accession | P22421 | | Bait Uniprot Identifier | VE4_HPV47 | | Bait Gene Name | E4 | | Sequence Position | 90-95 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21284 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12782328 | | Comments | The LC8 dynein light chain binding motif in Human papillomavirus type 47 protein E4 that binds to the rat 8 kDa Dynein light chain 1 (Dynll1) |
Record No : 98 |
| Instance ID | 11285 | | Regular Expression | [KR]xTQTx | | Motif Instance | KQTQTP | | Bait Uniprot Accession | P06425 | | Bait Uniprot Identifier | VE4_HPV08 | | Bait Gene Name | E4 | | Sequence Position | 23-28 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21285 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12782328 | | Comments | The LC8 dynein light chain binding motif in Human papillomavirus type 8 protein E4 that binds to the rat 8 kDa Dynein light chain 1 (Dynll1) |
Record No : 99 |
| Instance ID | 11286 | | Regular Expression | [KR]xTQTx | | Motif Instance | KQTQTP | | Bait Uniprot Accession | P06924 | | Bait Uniprot Identifier | VE4_HPV05 | | Bait Gene Name | E4 | | Sequence Position | 23-28 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21286 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12782328 | | Comments | The LC8 dynein light chain binding motif in Human papillomavirus type 5 protein E4 that binds to the rat 8 kDa Dynein light chain 1 (Dynll1) |
Record No : 100 |
| Instance ID | 11287 | | Regular Expression | [KR]xTQTx | | Motif Instance | KQTQTP | | Bait Uniprot Accession | P26550 | | Bait Uniprot Identifier | VE4_HPV5B | | Bait Gene Name | E4 | | Sequence Position | 23-28 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21287 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12782328 | | Comments | The LC8 dynein light chain binding motif in Human papillomavirus type 5b protein E4 that binds to the rat 8 kDa Dynein light chain 1 (Dynll1) |
Record No : 101 |
| Instance ID | 11293 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | DYTTQTV | | Bait Uniprot Accession | Q24312 | | Bait Uniprot Identifier | EWG_DROME | | Bait Gene Name | ewg | | Sequence Position | 540-546 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21293 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11069771 | | Comments | The LC8 dynein light chain binding motif in Drosophila DNA-binding protein erect wing (ewg) that binds to the mouse 8 kDa Dynein light chain 1 (Dynll1) |
Record No : 102 |
| Instance ID | 11312 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | DAESQTL | | Bait Uniprot Accession | P92030 | | Bait Uniprot Identifier | P92030_DROME | | Bait Gene Name | egl | | Sequence Position | 951-957 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21312 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in Drosophila Egalitarian protein (egl) that interacts with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8) |
Record No : 103 |
| Instance ID | 11313 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | DAESQTL | | Bait Uniprot Accession | P92030 | | Bait Uniprot Identifier | P92030_DROME | | Bait Gene Name | egl | | Sequence Position | 951-957 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21313 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in Drosophila Egalitarian protein (egl) that interacts with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2) |
Record No : 104 |
| Instance ID | 11460 | | Regular Expression | LxxLL | | Motif Instance | LSELL | | Bait Uniprot Accession | B2RWS6 | | Bait Uniprot Identifier | EP300_MOUSE | | Bait Gene Name | Ep300 | | Sequence Position | 81-85 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21460 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8616895, 9192902 | | Comments | Conserved motif on Ep300 for interaction with the Retinoic acid receptor |
Record No : 105 |
| Instance ID | 11461 | | Regular Expression | LxxLL | | Motif Instance | LSELL | | Bait Uniprot Accession | B2RWS6 | | Bait Uniprot Identifier | EP300_MOUSE | | Bait Gene Name | Ep300 | | Sequence Position | 81-85 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21461 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8616895, 9192902 | | Comments | Conserved motif on Ep300 for interaction with the the Glucocorticoid receptor |
Record No : 106 |
| Instance ID | 11462 | | Regular Expression | LxxLL | | Motif Instance | LVLLL | | Bait Uniprot Accession | B2RWS6 | | Bait Uniprot Identifier | EP300_MOUSE | | Bait Gene Name | Ep300 | | Sequence Position | 343-347 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21462 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8616895, 9192902 | | Comments | Conserved motif on Ep300 for interaction with the Retinoic acid receptor |
Record No : 107 |
| Instance ID | 11463 | | Regular Expression | LxxLL | | Motif Instance | LVLLL | | Bait Uniprot Accession | B2RWS6 | | Bait Uniprot Identifier | EP300_MOUSE | | Bait Gene Name | Ep300 | | Sequence Position | 343-347 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21463 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8616895, 9192902 | | Comments | Conserved motif on Ep300 for interaction with the the Glucocorticoid receptor |
Record No : 108 |
| Instance ID | 11498 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQL | | Bait Uniprot Accession | P03126 | | Bait Uniprot Identifier | VE6_HPV16 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | SPR; Mutational analysis; Pull down(GST tag); In vitro-degradation assay | | Interaction ID | 21498 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 20842623, 11077444 | | Comments | C-terminal sequences in E6 oncoprotein of Human papillomavirus type 16 carrying the consensus PDZ-binding motif which binds to the PDZ1 domain of MAGI-1 (MAGuK inverted protein 1) |
Record No : 109 |
| Instance ID | 11499 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQV | | Bait Uniprot Accession | P06463 | | Bait Uniprot Identifier | VE6_HPV18 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; SPR; Mutational analysis; Pull down(GST tag); In vitro degradation assay | | Interaction ID | 21499 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 20842623, 17267502, 11077444 | | Comments | C-terminal sequences in E6 oncoprotein of Human papillomavirus type 18 carrying the consensus PDZ-binding motif which binds to the PDZ1 domain of MAGI-1 (MAGuK inverted protein 1) |
Record No : 110 |
| Instance ID | 11500 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQV | | Bait Uniprot Accession | P17386 | | Bait Uniprot Identifier | VE6_HPV31 | | Bait Gene Name | E6 | | Sequence Position | 147-149 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | SPR; Mutational analysis | | Interaction ID | 21500 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 20842623 | | Comments | C-terminal sequences in E6 oncoprotein of Human papillomavirus type 31 carrying the consensus PDZ-binding motif which binds to the PDZ1 domain of MAGI-1 (MAGuK inverted protein 1) |
Record No : 111 |
| Instance ID | 11501 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TAL | | Bait Uniprot Accession | P06427 | | Bait Uniprot Identifier | VE6_HPV33 | | Bait Gene Name | E6 | | Sequence Position | 147-149 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | SPR; Mutational analysis | | Interaction ID | 21501 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 20842623 | | Comments | C-terminal sequences in E6 oncoprotein of Human papillomavirus type 33 carrying the consensus PDZ-binding motif which binds to the PDZ1 domain of MAGI-1 (MAGuK inverted protein 1) |
Record No : 112 |
| Instance ID | 11502 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQV | | Bait Uniprot Accession | P21735 | | Bait Uniprot Identifier | VE6_HPV45 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | SPR; Mutational analysis | | Interaction ID | 21502 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 20842623 | | Comments | C-terminal sequences in E6 oncoprotein of Human papillomavirus type 45 carrying the consensus PDZ-binding motif which binds to the PDZ1 domain of MAGI-1 (MAGuK inverted protein 1) |
Record No : 113 |
| Instance ID | 11503 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQV | | Bait Uniprot Accession | P36814 | | Bait Uniprot Identifier | VE6_HPV52 | | Bait Gene Name | E6 | | Sequence Position | 146-148 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | SPR; Mutational analysis | | Interaction ID | 21503 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 20842623 | | Comments | C-terminal sequences in E6 oncoprotein of Human papillomavirus type 52 carrying the consensus PDZ-binding motif which binds to the PDZ1 domain of MAGI-1 (MAGuK inverted protein 1) |
Record No : 114 |
| Instance ID | 11504 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQV | | Bait Uniprot Accession | P26555 | | Bait Uniprot Identifier | VE6_HPV58 | | Bait Gene Name | E6 | | Sequence Position | 147-149 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | SPR; Mutational analysis | | Interaction ID | 21504 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 20842623 | | Comments | C-terminal sequences in E6 oncoprotein of Human papillomavirus type 58 carrying the consensus PDZ-binding motif which binds to the PDZ1 domain of MAGI-1 (MAGuK inverted protein 1) |
Record No : 115 |
| Instance ID | 11505 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TLV | | Bait Uniprot Accession | P89079 | | Bait Uniprot Identifier | E4OR1_ADE09 | | Bait Gene Name | E4 | | Sequence Position | 123-125 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | SPR; Mutational analysis | | Interaction ID | 21505 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 20842623, 11077444 | | Comments | C-terminal PDZ domain-binding motif in the Ad9 E4-ORF1 oncoprotein which bind to PDZ1 and PDZ3 of MAGI-1 and inhibit its function in cells by aberrantly sequestering it to the cytoplasm |
Record No : 116 |
| Instance ID | 11512 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQL | | Bait Uniprot Accession | P03126 | | Bait Uniprot Identifier | VE6_HPV16 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down; Co-IP | | Interaction ID | 21512 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 9326658, 10523825 | | Comments | C terminal binding motif of E6 oncoprotein of Human papillomavirus type 16 that binds to the second PDZ domain of DLG and causes a dramatic reduction in the levels of DLG expression by targeting it for proteasome mediated degradation |
Record No : 117 |
| Instance ID | 11513 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TLV | | Bait Uniprot Accession | P89079 | | Bait Uniprot Identifier | E4OR1_ADE09 | | Bait Gene Name | E4 | | Sequence Position | 123-125 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21513 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 9192623 | | Comments | C-terminal PDZ domain-binding motif in the Ad9 E4-ORF1 oncoprotein that mediates its binding to hDLG/SAP97, the mammalian homolog for the Drosophila discs large tumor suppressor protein Dlg-A |
Record No : 118 |
| Instance ID | 11517 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQL | | Bait Uniprot Accession | P03126 | | Bait Uniprot Identifier | VE6_HPV16 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down | | Interaction ID | 21517 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17121805 | | Comments | Class I PDZ-domain binding motif in E6 oncoprotein of Human papillomavirus type 16 for binding and degradation of DLG4/PSD95 |
Record No : 119 |
| Instance ID | 11518 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQV | | Bait Uniprot Accession | P06463 | | Bait Uniprot Identifier | VE6_HPV18 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down | | Interaction ID | 21518 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17121805 | | Comments | Class I PDZ-domain binding motif in E6 oncoprotein of Human papillomavirus type 18 for binding and degradation of DLG4/PSD95 |
Record No : 120 |
| Instance ID | 11519 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQL | | Bait Uniprot Accession | P03126 | | Bait Uniprot Identifier | VE6_HPV16 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21519 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12140759 | | Comments | PDZ binding motif in E6 oncoprotein of Human papillomavirus type 16 for binding to MAGI-2 |
Record No : 121 |
| Instance ID | 11520 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQV | | Bait Uniprot Accession | P06463 | | Bait Uniprot Identifier | VE6_HPV18 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21520 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12140759 | | Comments | PDZ binding motif in E6 oncoprotein of Human papillomavirus type 18 for binding to MAGI-2 |
Record No : 122 |
| Instance ID | 11521 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQL | | Bait Uniprot Accession | P03126 | | Bait Uniprot Identifier | VE6_HPV16 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21521 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12140759 | | Comments | PDZ binding motif in E6 oncoprotein of Human papillomavirus type 16 for binding to the PDZ1 domain of MAGI-3 |
Record No : 123 |
| Instance ID | 11522 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQV | | Bait Uniprot Accession | P06463 | | Bait Uniprot Identifier | VE6_HPV18 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21522 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12140759 | | Comments | PDZ binding motif in E6 oncoprotein of Human papillomavirus type 18 for binding to the PDZ1 domain of MAGI-3 |
Record No : 124 |
| Instance ID | 11523 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQL | | Bait Uniprot Accession | P03126 | | Bait Uniprot Identifier | VE6_HPV16 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21523 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11027293 | | Comments | PDZ binding epitope of E6 oncoprotein of Human papillomavirus type 16 that mediates its binding to the human homolog of the Drosophila PDZ domain-containing tumor suppressor protein Scribble, hScrib, which is associated with cell junction complexes |
Record No : 125 |
| Instance ID | 11524 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQV | | Bait Uniprot Accession | P24835 | | Bait Uniprot Identifier | VE6_HPV39 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21524 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11027293 | | Comments | PDZ binding epitope of E6 oncoprotein of Human papillomavirus type 39 that mediates its binding to the human homolog of the Drosophila PDZ domain-containing tumor suppressor protein Scribble, hScrib, which is associated with cell junction complexes |
Record No : 126 |
| Instance ID | 11525 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQV | | Bait Uniprot Accession | P06463 | | Bait Uniprot Identifier | VE6_HPV18 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21525 | | Interacting Domain | PDZ domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11000240 | | Comments | PDZ domain-binding motif in E6 oncoprotein of Human papillomavirus type 18 that mediates binding to the PDZ7 and PDZ10 domains of rat Mupp1 (Mpdz) |
Record No : 127 |
| Instance ID | 11526 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQL | | Bait Uniprot Accession | P03126 | | Bait Uniprot Identifier | VE6_HPV16 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21526 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16878151 | | Comments | PDZ binding motif in E6 oncoprotein of Human papillomavirus type 16 that binds to and promotes the degradation of CAL (GOPC) through the ubiquitin-proteasome pathway |
Record No : 128 |
| Instance ID | 11527 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQV | | Bait Uniprot Accession | P06463 | | Bait Uniprot Identifier | VE6_HPV18 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21527 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16878151 | | Comments | PDZ binding motif in E6 oncoprotein of Human papillomavirus type 18 that binds to and promotes the degradation of CAL (GOPC) through the ubiquitin-proteasome pathway |
Record No : 129 |
| Instance ID | 11528 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQL | | Bait Uniprot Accession | P03126 | | Bait Uniprot Identifier | VE6_HPV16 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21528 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17166906, 15492812 | | Comments | PDZ binding motif in E6 oncoprotein of Human papillomavirus type 16 which mediates the binding and degradation of the protein tyrosine phosphatase PTPN3 (PTPH1) |
Record No : 130 |
| Instance ID | 11529 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQV | | Bait Uniprot Accession | P06463 | | Bait Uniprot Identifier | VE6_HPV18 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Mutational analysis | | Interaction ID | 21529 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17166906, 15492812 | | Comments | PDZ binding motif in E6 oncoprotein of Human papillomavirus type 18 which mediates the binding and degradation of the protein tyrosine phosphatase PTPN3 (PTPH1) |
Record No : 131 |
| Instance ID | 11530 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQL | | Bait Uniprot Accession | P03126 | | Bait Uniprot Identifier | VE6_HPV16 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21530 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18160445 | | Comments | PDZ binding motif in E6 oncoprotein of Human papillomavirus type 16 that interacts with and induces loss of human PTPN13 |
Record No : 132 |
| Instance ID | 11531 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQL | | Bait Uniprot Accession | P03126 | | Bait Uniprot Identifier | VE6_HPV16 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21531 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18160445 | | Comments | PDZ binding motif in E6 oncoprotein of Human papillomavirus type 16 that interacts with and induces loss of mouse PTPN13 |
Record No : 133 |
| Instance ID | 11532 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQL | | Bait Uniprot Accession | P03126 | | Bait Uniprot Identifier | VE6_HPV16 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21532 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15492812 | | Comments | PDZ binding motif in E6 oncoprotein of Human papillomavirus type 16 for binding to Tax interacting protein 1 (Tip-1) [also known as Tax1-binding protein 3 (TAX1BP3)] |
Record No : 134 |
| Instance ID | 11545 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQV | | Bait Uniprot Accession | P06463 | | Bait Uniprot Identifier | VE6_HPV18 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21545 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15767424 | | Comments | PDZ binding motif in E6 oncoprotein of Human papillomavirus type 18 which mediates the binding and degradation of human TIP-2/GIPC1 |
Record No : 135 |
| Instance ID | 11546 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQV | | Bait Uniprot Accession | P06463 | | Bait Uniprot Identifier | VE6_HPV18 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21546 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17287269 | | Comments | PDZ binding motif in E6 oncoprotein of Human papillomavirus type 18 that binds to PDZ 4 and 5 and mediates the degradation of the tight junction-associated multi-PDZ protein PATJ (INADL) |
Record No : 136 |
| Instance ID | 11547 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TQL | | Bait Uniprot Accession | P03126 | | Bait Uniprot Identifier | VE6_HPV16 | | Bait Gene Name | E6 | | Sequence Position | 156-158 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21547 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17287269 | | Comments | PDZ binding motif in E6 oncoprotein of Human papillomavirus type 16 that binds to and mediates the degradation of the tight junction-associated multi-PDZ protein PATJ (INADL) |
Record No : 137 |
| Instance ID | 11785 | | Regular Expression | [AET]xYLxxLN | | Motif Instance | ARYLQKLN | | Bait Uniprot Accession | Q19KW5 | | Bait Uniprot Identifier | Q19KW5_STREQ | | Bait Gene Name | emm | | Sequence Position | 81-88 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; SPR | | Interaction ID | 21785 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17452321, 16278217 | | Comments | The octapeptide collagen-binding motif in the M protein of Streptococcus dysgalactiae subsp. equisimilis that helps to bind the Collagen alpha-1(I) chain |
Record No : 138 |
| Instance ID | 11786 | | Regular Expression | [AET]xYLxxLN | | Motif Instance | ARYLQKLN | | Bait Uniprot Accession | Q19KW5 | | Bait Uniprot Identifier | Q19KW5_STREQ | | Bait Gene Name | emm | | Sequence Position | 81-88 | | Critical Residues | P1; P3; P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; SPR; Peptide binding assay | | Interaction ID | 21786 | | Interacting Domain | CB3 region | | Disease Association(s) | Rheumatic fever | | Inhibitor(s) | Unknown | | Reference(s) | 17452321, 19520603 | | Comments | The octapeptide collagen-binding motif known as “Peptide Associated with Rheumatic Fever” (PARF) in the M protein of Streptococcus dysgalactiae subsp. equisimilis that helps to bind the CB3-region of human Collagen alpha-4(IV) chain |
Record No : 139 |
| Instance ID | 11787 | | Regular Expression | [AET]xYLxxLN | | Motif Instance | AWYLKELN | | Bait Uniprot Accession | O85813 | | Bait Uniprot Identifier | O85813_STRSG | | Bait Gene Name | emm | | Sequence Position | 83-90 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21787 | | Interacting Domain | CB3 region | | Disease Association(s) | Rheumatic fever | | Inhibitor(s) | Unknown | | Reference(s) | 19520603 | | Comments | The octapeptide collagen-binding motif known as “Peptide Associated with Rheumatic Fever” (PARF) in the M protein of Streptococcus sp. group G that helps to bind the CB3-region of human Collagen alpha-4(IV) chain |
Record No : 140 |
| Instance ID | 11788 | | Regular Expression | [AET]xYLxxLN | | Motif Instance | TQYLKRLN | | Bait Uniprot Accession | Q1KQ03 | | Bait Uniprot Identifier | Q1KQ03_STREQ | | Bait Gene Name | emm | | Sequence Position | 79-86 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21788 | | Interacting Domain | CB3 region | | Disease Association(s) | Rheumatic fever | | Inhibitor(s) | Unknown | | Reference(s) | 19520603 | | Comments | The octapeptide collagen-binding motif known as “Peptide Associated with Rheumatic Fever” (PARF) in the M protein of Streptococcus dysgalactiae subsp. equisimilis that helps to bind the CB3-region of human Collagen alpha-4(IV) chain |
Record No : 141 |
| Instance ID | 11789 | | Regular Expression | [AET]xYLxxLN | | Motif Instance | AEYLKGLN | | Bait Uniprot Accession | Q54835 | | Bait Uniprot Identifier | Q54835_STRPY | | Bait Gene Name | emm3 | | Sequence Position | 94-101 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 21789 | | Interacting Domain | CB3 region | | Disease Association(s) | Rheumatic fever | | Inhibitor(s) | Unknown | | Reference(s) | 19520603 | | Comments | The octapeptide collagen-binding motif known as “Peptide Associated with Rheumatic Fever” (PARF) in the M3 protein of Streptococcus pyogenes that helps to bind the CB3-region of human Collagen alpha-4(IV) chain |
Record No : 142 |
| Instance ID | 11799 | | Regular Expression | [DE][LI]xCxE | | Motif Instance | DLYCYE | | Bait Uniprot Accession | P03129 | | Bait Uniprot Identifier | VE7_HPV16 | | Bait Gene Name | E7 | | Sequence Position | 21-26 | | Critical Residues | P1; P3; P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | X-ray crystallography; Mutational analysis; ITC; Competition binding assay | | Interaction ID | 21799 | | Interacting Domain | B-box portion of the Rb pocket domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 2198278, 9495340 | | Comments | The LxCxE motif of the human papilloma virus type-16 E7 protein (HPV-16 E7) that binds a highly conserved groove on the B-box portion of the pocket domain of the human retinoblastoma suppressor protein (pRb) and is believed to be important in the process of cellular transformation that leads to cervical carcinoma |
Record No : 143 |
| Instance ID | 11857 | | Regular Expression | [ND]xY[ST]xxP | | Motif Instance | QRYSSDP | | Bait Uniprot Accession | P00533 | | Bait Uniprot Identifier | EGFR_HUMAN | | Bait Gene Name | EGFR | | Sequence Position | 1067-1073 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Tyr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Sequence based prediction | | Interaction ID | 21857 | | Interacting Domain | TKB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15737992, 10635327 | | Comments | Consensus sequence for phosphotyrosine recognition by the Cbl TKB domain in human Epidermal growth factor receptor, which indicates that Cbl adaptor proteins directly control downregulation of the receptor for the epidermal growth factor (EGFR) by recruiting ubiquitin-activating and -conjugating enzymes |
Record No : 144 |
| Instance ID | 11874 | | Regular Expression | DALDL | | Motif Instance | DALDL | | Bait Uniprot Accession | Q51451 | | Bait Uniprot Identifier | Q51451_PSEAI | | Bait Gene Name | exoS | | Sequence Position | 424-428 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21874 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10213629, 16420486 | | Comments | A non-phosphorylated motif on ADP-ribosyltransferase toxin exoenzyme S (exoS) of Pseudomonas aeruginosa which is responsible for its specific interaction with 14-3-3 protein zeta |
Record No : 145 |
| Instance ID | 11875 | | Regular Expression | DALDL | | Motif Instance | DALDL | | Bait Uniprot Accession | Q51451 | | Bait Uniprot Identifier | Q51451_PSEAI | | Bait Gene Name | exoS | | Sequence Position | 424-428 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21875 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16420486 | | Comments | A non-phosphorylated motif on ADP-ribosyltransferase toxin exoenzyme S (exoS) of Pseudomonas aeruginosa which is responsible for its specific interaction with 14-3-3 protein beta |
Record No : 146 |
| Instance ID | 11876 | | Regular Expression | DALDL | | Motif Instance | DALDL | | Bait Uniprot Accession | Q51451 | | Bait Uniprot Identifier | Q51451_PSEAI | | Bait Gene Name | exoS | | Sequence Position | 424-428 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21876 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16420486 | | Comments | A non-phosphorylated motif on ADP-ribosyltransferase toxin exoenzyme S (exoS) of Pseudomonas aeruginosa which is responsible for its specific interaction with 14-3-3 protein epsilon |
Record No : 147 |
| Instance ID | 11877 | | Regular Expression | DALDL | | Motif Instance | DALDL | | Bait Uniprot Accession | Q51451 | | Bait Uniprot Identifier | Q51451_PSEAI | | Bait Gene Name | exoS | | Sequence Position | 424-428 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21877 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16420486 | | Comments | A non-phosphorylated motif on ADP-ribosyltransferase toxin exoenzyme S (exoS) of Pseudomonas aeruginosa which is responsible for its specific interaction with 14-3-3 protein gamma |
Record No : 148 |
| Instance ID | 11878 | | Regular Expression | DALDL | | Motif Instance | DALDL | | Bait Uniprot Accession | Q51451 | | Bait Uniprot Identifier | Q51451_PSEAI | | Bait Gene Name | exoS | | Sequence Position | 424-428 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21878 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16420486 | | Comments | A non-phosphorylated motif on ADP-ribosyltransferase toxin exoenzyme S (exoS) of Pseudomonas aeruginosa which is responsible for its specific interaction with 14-3-3 protein eta |
Record No : 149 |
| Instance ID | 11939 | | Regular Expression | NPxY | | Motif Instance | NPDY | | Bait Uniprot Accession | P21860 | | Bait Uniprot Identifier | ERBB3_HUMAN | | Bait Gene Name | ERBB3 | | Sequence Position | 1325-1328 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Competition binding assay | | Interaction ID | 21939 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8026468, 7537849 | | Comments | The tyrosine-phosphorylated NPXY motif of Receptor tyrosine-protein kinase erbB-3 that mediates its interaction with the PTB domain of SHC-transforming protein 1 |
Record No : 150 |
| Instance ID | 11941 | | Regular Expression | NPxY | | Motif Instance | NPDY | | Bait Uniprot Accession | P00533 | | Bait Uniprot Identifier | EGFR_HUMAN | | Bait Gene Name | EGFR | | Sequence Position | 1169-1172 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Competition binding assay; Dephosphorylation protection assay | | Interaction ID | 21941 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7542744, 7537849 | | Comments | The tyrosine-phosphorylated NPXY motif of Epidermal growth factor receptor that mediates its interaction with the PTB domain of SHC-transforming protein 1 |
Record No : 151 |
| Instance ID | 11944 | | Regular Expression | Y[VI]N | | Motif Instance | YIN | | Bait Uniprot Accession | P00533 | | Bait Uniprot Identifier | EGFR_HUMAN | | Bait Gene Name | EGFR | | Sequence Position | 1092-1094 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Competition binding assay; SPR; Dephosphorylation protection assay | | Interaction ID | 21944 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8491186, 7518560 | | Comments | The short sequence motif present in Epidermal growth factor receptor that specifically binds the SH2 domain of Growth factor receptor-bound protein 2 with high affinity |
Record No : 152 |
| Instance ID | 12147 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RHYSDS | | Bait Uniprot Accession | P06463 | | Bait Uniprot Identifier | VE6_HPV18 | | Bait Gene Name | E6 | | Sequence Position | 79-84 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 22147 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 23175360 | | Comments | Phosphoserine-containing 14-3-3 binding motif (pS82) of E6 oncoprotein of Human papillomavirus type 18 that binds to 14-3-3 protein zeta |
Record No : 153 |
| Instance ID | 12153 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RRLL | | Bait Uniprot Accession | P06791 | | Bait Uniprot Identifier | VE4_HPV18 | | Bait Gene Name | E4 | | Sequence Position | 43-46 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag); Competition binding | | Interaction ID | 22153 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23065011 | | Comments | The cyclin interaction motif (RXL motif) in the human papilloma virus E4 protein that directs binding to cyclin A |
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