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Total : 59 Records
Record No : 1 |
| Instance ID | 10012 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSCTWP | | Bait Uniprot Accession | P98177 | | Bait Uniprot Identifier | FOXO4_HUMAN | | Bait Gene Name | FOXO4 | | Sequence Position | 29-34 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Molecular sieving; Cosedimentation; Mutation analysis | | Interaction ID | 20012 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14690436 | | Comments | 14-3-3 binding motif in Forkhead box protein O4 that binds 14-3-3 protein zeta |
Record No : 2 |
| Instance ID | 10029 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RRAASMD | | Bait Uniprot Accession | P98177 | | Bait Uniprot Identifier | FOXO4_HUMAN | | Bait Gene Name | FOXO4 | | Sequence Position | 193-199 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 20029 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16114898 | | Comments | 14-3-3 protein zeta interaction with nuclear localization sequence of human forkhead transcription factor FoxO4 could inhibit interaction between FoxO4 and nuclear importing machinery and thus shift the equilibrium of FoxO4 localization toward the cytoplasm |
Record No : 3 |
| Instance ID | 10054 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSCTWP | | Bait Uniprot Accession | O43524 | | Bait Uniprot Identifier | FOXO3_HUMAN | | Bait Gene Name | FOXO3 | | Sequence Position | 29-34 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning | | Interaction ID | 20054 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11864996 | | Comments | 14-3-3 binding site (pT-32) in the human proapoptotic transcription factor FKHRL1 (or FOXO3) that mediates binding to 14-3-3 protein zeta |
Record No : 4 |
| Instance ID | 10062 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RAVSMD | | Bait Uniprot Accession | O43524 | | Bait Uniprot Identifier | FOXO3_HUMAN | | Bait Gene Name | FOXO3 | | Sequence Position | 250-255 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning | | Interaction ID | 20062 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11864996 | | Comments | 14-3-3 binding site (pS-253) in the human proapoptotic transcription factor FKHRL1 (or FOXO3) that mediates binding to 14-3-3 protein zeta |
Record No : 5 |
| Instance ID | 10183 | | Regular Expression | x[ILM]R$ | | Motif Instance | TIR | | Bait Uniprot Accession | Q8L3Z8 | | Bait Uniprot Identifier | FZR2_ARATH | | Bait Gene Name | FZR2 | | Sequence Position | 481-483 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 20183 | | Interacting Domain | Tetratricopeptide repeats | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17944809 | | Comments | Interaction between Arabidopsis Cell cycle switch protein CCS52A1/FZR2/CDH1-2 and one of the Arabidopsis CDC27 subunit in the anaphase-promoting complex (APC/C), HBT/CDC27B, probably mediated by the IR tail of CCS52A1 |
Record No : 6 |
| Instance ID | 10184 | | Regular Expression | x[ILM]R$ | | Motif Instance | QIR | | Bait Uniprot Accession | Q8LPL5 | | Bait Uniprot Identifier | FZR3_ARATH | | Bait Gene Name | FZR3 | | Sequence Position | 479-481 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 20184 | | Interacting Domain | Tetratricopeptide repeats | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17944809 | | Comments | Interaction between Arabidopsis Cell cycle switch protein CCS52B/FZR3/CDH1-3 and one of the Arabidopsis CDC27 subunit in the anaphase-promoting complex (APC/C), HBT/CDC27B, probably mediated by the IR tail of CCS52B |
Record No : 7 |
| Instance ID | 10187 | | Regular Expression | x[ILM]R$ | | Motif Instance | RIR | | Bait Uniprot Accession | Q9UM11 | | Bait Uniprot Identifier | FZR_HUMAN | | Bait Gene Name | FZR1 | | Sequence Position | 494-496 | | Critical Residues | P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation disrupting interaction; Cross linking studies; Mutation analysis; Ubiquitinase assay; Peptide binding to perpetrator; Competition binding; Pull down | | Interaction ID | 20187 | | Interacting Domain | Tetratricopeptide repeats | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15916961, 12956947 | | Comments | Conserved C-terminal motif found in human CDH1 that mediates binding to the TPR domain in APC3 |
Record No : 8 |
| Instance ID | 10214 | | Regular Expression | x(S)xxF | | Motif Instance | RSPTF | | Bait Uniprot Accession | Q6UWZ7 | | Bait Uniprot Identifier | F175A_HUMAN | | Bait Gene Name | FAM175A | | Sequence Position | 405-409 | | Critical Residues | P2 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down | | Interaction ID | 20214 | | Interacting Domain | BRCT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17525340 | | Comments | Phosphorylated serine (pS) sequence in human BRCA1-A complex subunit Abraxas (FAM175A) that directly binds the BRCA1 BRCT repeats |
Record No : 9 |
| Instance ID | 10408 | | Regular Expression | x[FYH]x[IVM][^WFYP][^WFYP][ILM][ILMV]x | | Motif Instance | PFSINNLMS | | Bait Uniprot Accession | P55317 | | Bait Uniprot Identifier | FOXA1_HUMAN | | Bait Gene Name | FOXA1 | | Sequence Position | 399-407 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 20408 | | Interacting Domain | WD domain, G-beta repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10748198 | | Comments | The eh1 motif in human Hepatocyte nuclear factor 3-alpha that binds to the WD40 domain of human Transducin-like enhancer protein 1 |
Record No : 10 |
| Instance ID | 10422 | | Regular Expression | ([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P) | | Motif Instance | FPPPP | | Bait Uniprot Accession | O15117 | | Bait Uniprot Identifier | FYB_HUMAN | | Bait Gene Name | FYB | | Sequence Position | 616-620 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Ligand overlay assay; Co-IP; Far Western blotting | | Interaction ID | 20422 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10747096 | | Comments | Proline-rich motif within human FYN-binding protein (FYB/SLAP130) that is required for its interaction with VASP |
Record No : 11 |
| Instance ID | 10553 | | Regular Expression | [LMV]PxLE | | Motif Instance | LPPLE | | Bait Uniprot Accession | Q14318 | | Bait Uniprot Identifier | FKBP8_HUMAN | | Bait Gene Name | FKBP8 | | Sequence Position | 52-56 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | FRET; subcellular preparation; Colocalization; Pull down; Mutation analysis; ITC; Fluorescence polarization spectroscopy; Competition binding; Affinity chromatography technology; protein array; Co-IP; Mass spectrometry | | Interaction ID | 20553 | | Interacting Domain | MYND domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19546213, 23413029 | | Comments | The MYND-type Zinc Finger of human Prolyl hydroxylase domain protein 2 (PHD2/EGLN1) binds a PxLE motif found in human Peptidyl-prolyl cis-trans isomerase FKBP8 (or FKBP38) |
Record No : 12 |
| Instance ID | 10554 | | Regular Expression | FxxA[ILV]xxAxx[ILV] | | Motif Instance | FKDALQRARQI | | Bait Uniprot Accession | Q96AE4 | | Bait Uniprot Identifier | FUBP1_HUMAN | | Bait Gene Name | FUBP1 | | Sequence Position | 31-41 | | Critical Residues | P1; P4; P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20554 | | Interacting Domain | RNP domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 20711187 | | Comments | The Nbox motif of FUSE-binding protein 1 (FUBP1/FBP) that is responsible for recruiting FBP-interacting repressor (FIR) protein to the FUSE DNA sequence |
Record No : 13 |
| Instance ID | 10624 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QGRLDDFFKV | | Bait Uniprot Accession | P39748 | | Bait Uniprot Identifier | FEN1_HUMAN | | Bait Gene Name | FEN1 | | Sequence Position | 337-346 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography; Peptide mapping; Y2H; Co-IP; Competition binding assay | | Interaction ID | 20624 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15576034, 9178907 | | Comments | The PCNA binding PIP box motif in human Flap endonuclease 1 (FEN1)/ DNase IV that mediates interaction with human Proliferating cell nuclear antigen (PCNA/Cyclin) |
Record No : 14 |
| Instance ID | 10635 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | QDGTEV | | Bait Uniprot Accession | Q86XX4 | | Bait Uniprot Identifier | FRAS1_HUMAN | | Bait Gene Name | FRAS1 | | Sequence Position | 4002-4007 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Fluorescence polarization spectroscopy; X-ray crystallography | | Interaction ID | 20635 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18155042 | | Comments | C-terminal class 1 PDZ-binding motif in human Extracellular matrix protein FRAS1 that binds to the rat Grip1 PDZ12 domain |
Record No : 15 |
| Instance ID | 10712 | | Regular Expression | xP[^P]I[^P][IV][^P] | | Motif Instance | LPVIAVN | | Bait Uniprot Accession | Q99332 | | Bait Uniprot Identifier | HPH1_YEAST | | Bait Gene Name | FRT1 | | Sequence Position | 71-77 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20712 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15189990 | | Comments | In Saccharomyces cerevisiae, calcineurin directly dephosphorylates High pH protein 1 (Hph1p) and interacts with it through the calcineurin docking motif in Hph1p |
Record No : 16 |
| Instance ID | 10810 | | Regular Expression | RGD | | Motif Instance | RGD | | Bait Uniprot Accession | P02751 | | Bait Uniprot Identifier | FINC_HUMAN | | Bait Gene Name | FN1 | | Sequence Position | 1524-1526 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20810 | | Interacting Domain | FG-GAP repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22451694 | | Comments | Human Integrin alpha-5 is a major cellular receptor for the extracellular matrix protein fibronectin that binds to the RGD motif in Human Fibronectin (FN1) |
Record No : 17 |
| Instance ID | 10838 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGYSS | | Bait Uniprot Accession | Q9UKT4 | | Bait Uniprot Identifier | FBX5_HUMAN | | Bait Gene Name | FBXO5 | | Sequence Position | 144-149 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Protein kinase assay; Knock out; Classical fluorescence spectroscopy | | Interaction ID | 20838 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12791266 | | Comments | The DSGxxS phospho-dependent degron in human F-box only protein 5 (FBXO5) that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC), a component of the SCF ubiquitin ligase complex |
Record No : 18 |
| Instance ID | 10844 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGIDS | | Bait Uniprot Accession | P98174 | | Bait Uniprot Identifier | FGD1_HUMAN | | Bait Gene Name | FGD1 | | Sequence Position | 282-287 | | Critical Residues | P2 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Radiolabel; Alanine scanning | | Interaction ID | 20844 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Faciogenital dysplasia | | Inhibitor(s) | Unknown | | Reference(s) | 15743413 | | Comments | The DSGxxS phospho-dependent degron in human FGD1, the Cdc42 guanine nucleotide exchange factor (GEF) responsible for faciogenital dysplasia, that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC), substrate recognition subunit of the SCF ubiquitin ligase complex |
Record No : 19 |
| Instance ID | 10845 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGIDS | | Bait Uniprot Accession | Q5JSP0 | | Bait Uniprot Identifier | FGD3_HUMAN | | Bait Gene Name | FGD3 | | Sequence Position | 75-80 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Thr-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Classical fluorescence spectroscopy; Western blot; Alanine scanning | | Interaction ID | 20845 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Faciogenital dysplasia | | Inhibitor(s) | Unknown | | Reference(s) | 18363964 | | Comments | The DSGxxS phospho-dependent degron in human FGD3, a putative Cdc42 guanine nucleotide exchange factor (GEF), that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC), substrate recognition subunit of the SCF ubiquitin ligase complex |
Record No : 20 |
| Instance ID | 10959 | | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | | Motif Instance | VILLDEDED | | Bait Uniprot Accession | P40020 | | Bait Uniprot Identifier | FIR1_YEAST | | Bait Gene Name | FIR1 | | Sequence Position | 759-767 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Y2H | | Interaction ID | 20959 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15590687 | | Comments | The potential SUMO-binding motif in Fir1 protein of Saccharomyces cerevisiae that mediates interactions with Ubiquitin-like protein Smt3 in Saccharomyces cerevisiae |
Record No : 21 |
| Instance ID | 10997 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | TRNPADGI | | Bait Uniprot Accession | Q6V0I7 | | Bait Uniprot Identifier | FAT4_HUMAN | | Bait Gene Name | FAT4 | | Sequence Position | 4826-4833 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence polarization spectroscopy; Mutation analysis; Co-IP | | Interaction ID | 20997 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22153077 | | Comments | The N-terminal region of ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif in human Protocadherin FAT4 |
Record No : 22 |
| Instance ID | 11004 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | DRESPDGS | | Bait Uniprot Accession | Q96RU3 | | Bait Uniprot Identifier | FNBP1_HUMAN | | Bait Gene Name | FNBP1 | | Sequence Position | 514-521 | | Critical Residues | P2; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Y2H; Mutation analysis; Co-IP | | Interaction ID | 21004 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22153077, 14596906 | | Comments | The N-terminal region of ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif in human Formin-binding protein 1 (FNBP1) |
Record No : 23 |
| Instance ID | 11011 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | VRKQPEGN | | Bait Uniprot Accession | Q6V0I7 | | Bait Uniprot Identifier | FAT4_HUMAN | | Bait Gene Name | FAT4 | | Sequence Position | 4571-4578 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence polarization spectroscopy; Mutation analysis; Co-IP | | Interaction ID | 21011 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22153077 | | Comments | The N-terminal region of ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif in human Protocadherin FAT4 |
Record No : 24 |
| Instance ID | 11098 | | Regular Expression | xxx([ST])Px | | Motif Instance | EASTPE | | Bait Uniprot Accession | P01101 | | Bait Uniprot Identifier | FOS_MOUSE | | Bait Gene Name | Fos | | Sequence Position | 229-234 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Pull down | | Interaction ID | 21098 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16123044 | | Comments | The Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the phosphorylated Thr-232-Pro motif of mouse Proto-oncogene c-Fos |
Record No : 25 |
| Instance ID | 11099 | | Regular Expression | xxx([ST])Px | | Motif Instance | PLCTPV | | Bait Uniprot Accession | P01101 | | Bait Uniprot Identifier | FOS_MOUSE | | Bait Gene Name | Fos | | Sequence Position | 322-327 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Pull down | | Interaction ID | 21099 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16123044 | | Comments | The Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the phosphorylated Thr-325-Pro motif of mouse Proto-oncogene c-Fos |
Record No : 26 |
| Instance ID | 11100 | | Regular Expression | xxx([ST])Px | | Motif Instance | VTCTPG | | Bait Uniprot Accession | P01101 | | Bait Uniprot Identifier | FOS_MOUSE | | Bait Gene Name | Fos | | Sequence Position | 328-333 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Pull down | | Interaction ID | 21100 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16123044 | | Comments | The Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the phosphorylated Thr-331-Pro motif of mouse Proto-oncogene c-Fos |
Record No : 27 |
| Instance ID | 11101 | | Regular Expression | xxx([ST])Px | | Motif Instance | SLSSPT | | Bait Uniprot Accession | P01101 | | Bait Uniprot Identifier | FOS_MOUSE | | Bait Gene Name | Fos | | Sequence Position | 371-376 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Pull down | | Interaction ID | 21101 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16123044 | | Comments | The Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the phosphorylated Ser-374-Pro motif of mouse Proto-oncogene c-Fos |
Record No : 28 |
| Instance ID | 11140 | | Regular Expression | xxx([ST])Px | | Motif Instance | SNQSPK | | Bait Uniprot Accession | Q90Z80 | | Bait Uniprot Identifier | FBX5A_XENLA | | Bait Gene Name | fbxo5-a | | Sequence Position | 7-12 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Alanine scanning | | Interaction ID | 21140 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17159919 | | Comments | Early mitotic inhibitor 1-A (Emi1/fbxo5-a) binding to Prolyl isomerase Pin1 of Xenopus laevis depends on the phosphorylation of Ser-10 of Emi1 and on the WW domain of Pin1 |
Record No : 29 |
| Instance ID | 11159 | | Regular Expression | xxx([ST])Px | | Motif Instance | CSATPT | | Bait Uniprot Accession | Q969H0 | | Bait Uniprot Identifier | FBXW7_HUMAN | | Bait Gene Name | FBXW7 | | Sequence Position | 202-207 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Mutation analysis | | Interaction ID | 21159 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 22608923 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Thr-205-Pro motif of human F-box protein FBXW7, the substrate recognition component of the SCF E3 ligase complex, and promotes Fbw7 self-ubiquitination and protein degradation, thereby negatively regulating its tumor suppressor function |
Record No : 30 |
| Instance ID | 11187 | | Regular Expression | NGR | | Motif Instance | NGR | | Bait Uniprot Accession | P11276 | | Bait Uniprot Identifier | FINC_MOUSE | | Bait Gene Name | Fn1 | | Sequence Position | 264-266 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Peptide binding to perpetrator | | Interaction ID | 21187 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18480047 | | Comments | The NGR motif (264-266) within Mouse Fibronectin (Fn1) that directly associates with the beta3 subunit (ITGB3) of human alphavbeta3 integrin |
Record No : 31 |
| Instance ID | 11188 | | Regular Expression | NGR | | Motif Instance | NGR | | Bait Uniprot Accession | P11276 | | Bait Uniprot Identifier | FINC_MOUSE | | Bait Gene Name | Fn1 | | Sequence Position | 501-503 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Peptide binding to perpetrator | | Interaction ID | 21188 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18480047 | | Comments | The NGR motif (501-503) within Mouse Fibronectin (Fn1) that directly associates with the beta3 subunit (ITGB3) of human alphaVbeta3 integrin |
Record No : 32 |
| Instance ID | 11189 | | Regular Expression | NGR | | Motif Instance | NGR | | Bait Uniprot Accession | P02751 | | Bait Uniprot Identifier | FINC_HUMAN | | Bait Gene Name | FN1 | | Sequence Position | 263-265 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Affinity chromatography | | Interaction ID | 21189 | | Interacting Domain | Unknown | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 1532572 | | Comments | The NGR motif (263-265) within Human Fibronectin (FN1) that directly associates with the beta6 subunit (ITGB6) of human alphaVbeta6 integrin |
Record No : 33 |
| Instance ID | 11190 | | Regular Expression | NGR | | Motif Instance | NGR | | Bait Uniprot Accession | P02751 | | Bait Uniprot Identifier | FINC_HUMAN | | Bait Gene Name | FN1 | | Sequence Position | 367-369 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Affinity chromatography | | Interaction ID | 21190 | | Interacting Domain | Unknown | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 1532572 | | Comments | The NGR motif (367-369) within Human Fibronectin (FN1) that directly associates with the beta6 subunit (ITGB6) of human alphaVbeta6 integrin |
Record No : 34 |
| Instance ID | 11191 | | Regular Expression | NGR | | Motif Instance | NGR | | Bait Uniprot Accession | P02751 | | Bait Uniprot Identifier | FINC_HUMAN | | Bait Gene Name | FN1 | | Sequence Position | 501-503 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Affinity chromatography | | Interaction ID | 21191 | | Interacting Domain | Unknown | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 1532572 | | Comments | The NGR motif (501-503) within Human Fibronectin (FN1) that directly associates with the beta6 subunit (ITGB6) of human alphaVbeta6 integrin |
Record No : 35 |
| Instance ID | 11192 | | Regular Expression | NGR | | Motif Instance | NGR | | Bait Uniprot Accession | P02751 | | Bait Uniprot Identifier | FINC_HUMAN | | Bait Gene Name | FN1 | | Sequence Position | 1432-1434 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Affinity chromatography | | Interaction ID | 21192 | | Interacting Domain | Unknown | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 1532572 | | Comments | The NGR motif (1432-1434) within Human Fibronectin (FN1) that directly associates with the beta6 subunit (ITGB6) of human alphaVbeta6 integrin |
Record No : 36 |
| Instance ID | 11193 | | Regular Expression | NGR | | Motif Instance | NGR | | Bait Uniprot Accession | P35555 | | Bait Uniprot Identifier | FBN1_HUMAN | | Bait Gene Name | FBN1 | | Sequence Position | 2304-2306 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Solid phase binding assay | | Interaction ID | 21193 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8617364 | | Comments | The NGR motif (2304-2306) within Human Fibrillin-1 (FBN1) that directly associates with the beta3 subunit (ITGB3) of human alphavbeta3 integrin |
Record No : 37 |
| Instance ID | 11194 | | Regular Expression | xF[^P][^P][KRIL]H[^P][^P][YLMFH][^P]xxx | | Motif Instance | PFARLHECYGQEI | | Bait Uniprot Accession | Q8N4B1 | | Bait Uniprot Identifier | SESQ1_HUMAN | | Bait Gene Name | FAM109A | | Sequence Position | 223-235 | | Critical Residues | P2; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation disrupting interaction; X-ray crystallography; ITC; SPR; Y2H; Co-IP; Pull down(GST tag); Colocalization; Competition binding | | Interaction ID | 21194 | | Interacting Domain | ASH-RhoGAP-like domain | | Disease Association(s) | Lowe syndrome; Dent disease type 2 | | Inhibitor(s) | Unknown | | Reference(s) | 21233288, 20133602, 21666675 | | Comments | The conserved F and H motif in human Sesquipedalian-1 (FAM109A/IPIP27A) that binds to the ASH-RhoGAP-like domain of human OCRL1 |
Record No : 38 |
| Instance ID | 11195 | | Regular Expression | xF[^P][^P][KRIL]H[^P][^P][YLMFH][^P]xxx | | Motif Instance | CFSTLHDWYGQEI | | Bait Uniprot Accession | Q6ICB4 | | Bait Uniprot Identifier | SESQ2_HUMAN | | Bait Gene Name | FAM109B | | Sequence Position | 223-235 | | Critical Residues | P2; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation disrupting interaction; Y2H; Co-IP; Pull down(GST tag); ITC; SPR; Colocalization; Competition binding | | Interaction ID | 21195 | | Interacting Domain | ASH-RhoGAP-like domain | | Disease Association(s) | Lowe syndrome; Dent disease type 2 | | Inhibitor(s) | Unknown | | Reference(s) | 21233288, 20133602, 21666675 | | Comments | The conserved F and H motif in human Sesquipedalian-2 (FAM109B/IPIP27B) that binds to the ASH-RhoGAP-like domain of human OCRL1 |
Record No : 39 |
| Instance ID | 11199 | | Regular Expression | PPLP | | Motif Instance | PPLP | | Bait Uniprot Accession | Q05860 | | Bait Uniprot Identifier | FMN1_MOUSE | | Bait Gene Name | Fmn1 | | Sequence Position | 877-880 | | Critical Residues | P1; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Alanine scanning; Far Western blotting; Pull down(GST tag); Competition binding | | Interaction ID | 21199 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9171351, 8605874 | | Comments | The PPLP motif in mouse Formin-1 (Fmn1) that is recognized by the group II WW domain of mouse Formin-binding protein 11 (Fbp11) |
Record No : 40 |
| Instance ID | 11243 | | Regular Expression | xGxxPG | | Motif Instance | EGFEPG | | Bait Uniprot Accession | P35555 | | Bait Uniprot Identifier | FBN1_HUMAN | | Bait Gene Name | FBN1 | | Sequence Position | 2194-2199 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Type VIII reverse beta-turn | | Experimental Method(s) | Site-directed Mutagenesis; Chemotaxis assay | | Interaction ID | 21243 | | Interacting Domain | Elastin-binding domain of EBP | | Disease Association(s) | Marfan syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 16442122, 17030689 | | Comments | The 67-kD human elastin-binding protein (EBP) binds to a hexapeptide motif from human Fibrillin-1 (FBN1) |
Record No : 41 |
| Instance ID | 11495 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TLV | | Bait Uniprot Accession | O94868 | | Bait Uniprot Identifier | FCSD2_HUMAN | | Bait Gene Name | FCHSD2 | | Sequence Position | 738-740 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Co-IP; Pull down(GST tag) | | Interaction ID | 21495 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14627983 | | Comments | The PDZ-binding motif at the C-terminus of Carom (FCHSD2) which binds to the fifth PDZ domain (PDZ4) of MAGI-1 |
Record No : 42 |
| Instance ID | 11618 | | Regular Expression | [FY]x[VLI]$ | | Motif Instance | FLV | | Bait Uniprot Accession | Q9Y624 | | Bait Uniprot Identifier | JAM1_HUMAN | | Bait Gene Name | F11R | | Sequence Position | 297-299 | | Critical Residues | P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21618 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10877843, 11489913 | | Comments | The COOH-terminal class II PDZ-domain binding motif of human JAM (F11R) that directly interacts with PDZ3 domain of human Tight junction protein ZO-1 (TJP1) for recruitment of endogenous ZO-1 to cell–cell adhesion sites |
Record No : 43 |
| Instance ID | 11619 | | Regular Expression | [FY]x[VLI]$ | | Motif Instance | FLV | | Bait Uniprot Accession | Q9Y624 | | Bait Uniprot Identifier | JAM1_HUMAN | | Bait Gene Name | F11R | | Sequence Position | 297-299 | | Critical Residues | P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21619 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11489913 | | Comments | The COOH-terminal class II PDZ-domain binding motif of human JAM (F11R) that directly interacts with the PDZ domains of PAR-3 (PARD3) for recruitment of PAR-3 to cell–cell adhesion sites |
Record No : 44 |
| Instance ID | 11620 | | Regular Expression | [FY]x[VLI]$ | | Motif Instance | FLV | | Bait Uniprot Accession | O88792 | | Bait Uniprot Identifier | JAM1_MOUSE | | Bait Gene Name | F11r | | Sequence Position | 299-300 | | Critical Residues | P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21620 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11689568 | | Comments | The COOH-terminal class II PDZ-domain binding motif of mouse Jam (F11r) that specifically interacts with PDZ9 of mouse Mupp1 (Mpdz) for recruitment of Mupp1 to the cell-cell adhesion sites |
Record No : 45 |
| Instance ID | 11621 | | Regular Expression | [FY]x[VLI]$ | | Motif Instance | FLV | | Bait Uniprot Accession | O88792 | | Bait Uniprot Identifier | JAM1_MOUSE | | Bait Gene Name | F11r | | Sequence Position | 299-300 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag); Y2H | | Interaction ID | 21621 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10856295 | | Comments | The COOH-terminal class II PDZ-domain binding motif of mouse Jam (F11r) that binds the PDZ domain of mouse ALL1-fused gene from chromosome 6(AF-6) protein/Afadin (Mllt4) |
Record No : 46 |
| Instance ID | 11821 | | Regular Expression | Qxx[ILM]xx[FHY][FHY] | | Motif Instance | QGRLDDFF | | Bait Uniprot Accession | P39748 | | Bait Uniprot Identifier | FEN1_HUMAN | | Bait Gene Name | FEN1 | | Sequence Position | 337-344 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Peptide pulldown; Peptide mapping; Competition binding assay | | Interaction ID | 21821 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9178907, 9305916 | | Comments | The eight amino acid conserved PCNA-binding motif in Flap endonuclease 1 (or DNase IV) for binding the central loop of Proliferating cell nuclear antigen (PCNA) |
Record No : 47 |
| Instance ID | 11860 | | Regular Expression | NxY[STEQ] | | Motif Instance | NEYT | | Bait Uniprot Accession | P06241 | | Bait Uniprot Identifier | FYN_HUMAN | | Bait Gene Name | FYN | | Sequence Position | 418-421 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Tyr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Sequence based prediction | | Interaction ID | 21860 | | Interacting Domain | TKB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15737992, 10629042 | | Comments | Consensus sequence for phosphotyrosine recognition by the Cbl TKB domain in human Tyrosine-protein kinase Fyn that implicate Cbl as a component in the negative regulation of Fyn |
Record No : 48 |
| Instance ID | 11946 | | Regular Expression | FEWYYQ | | Motif Instance | FEWYYQ | | Bait Uniprot Accession | P21160 | | Bait Uniprot Identifier | A85B_MYCKA | | Bait Gene Name | fbpB | | Sequence Position | 98-103 | | Critical Residues | P1; P3; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutational analysis; Competition binding assay; ELISA; SPR | | Interaction ID | 21946 | | Interacting Domain | Fn14 fragment of Fn | | Disease Association(s) | Mycobacterial infection | | Inhibitor(s) | Unknown | | Reference(s) | 9446601, 22128161 | | Comments | The novel Fn-binding motif of the immunodominant antigen (Ag) alpha-Ag (Ag 85 complex B) of Mycobacterium kansasii for human fibronectin that is unique for mycobacteria |
Record No : 49 |
| Instance ID | 11947 | | Regular Expression | SLLVSWQPPR | | Motif Instance | SLLVSWQPPR | | Bait Uniprot Accession | P02751 | | Bait Uniprot Identifier | FINC_HUMAN | | Bait Gene Name | FN1 | | Sequence Position | 1918-1927 | | Critical Residues | P3; P4; P5; P7; P8; P9; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta sheet | | Experimental Method(s) | Alanine-scanning mutagenesis; Competition binding assay | | Interaction ID | 21947 | | Interacting Domain | Fibronectin-binding motif | | Disease Association(s) | Mycobacterial infection | | Inhibitor(s) | Unknown | | Reference(s) | 9446601, 22128161 | | Comments | The motif on human Fibronectin (Fn14) required for high affinity binding to the immunodominant antigen (Ag) alpha-Ag (Ag 85 complex B) of Mycobacterium |
Record No : 50 |
| Instance ID | 11949 | | Regular Expression | KTxxx[WI] | | Motif Instance | KTCFEW | | Bait Uniprot Accession | O42579 | | Bait Uniprot Identifier | FZD3_XENLA | | Bait Gene Name | fzd3 | | Sequence Position | 501-506 | | Critical Residues | P1; P2; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21949 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10990458 | | Comments | A conserved internal motif sequence in the C-terminal cytoplasmic region of Xenopus membrane-bound receptor Frizzled-3 (Xfz3) that may bind to the conventional peptide binding site in the PDZ domain of the mouse cytoplasmic protein Dishevelled (Dvl) suggesting a role of this conserved motif in the modulation of Wnt signalling |
Record No : 51 |
| Instance ID | 11950 | | Regular Expression | KTxxx[WI] | | Motif Instance | KTLHTW | | Bait Uniprot Accession | Q9PT62 | | Bait Uniprot Identifier | FZD4_XENLA | | Bait Gene Name | fzd4 | | Sequence Position | 485-490 | | Critical Residues | P1; P2; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21950 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10990458 | | Comments | A conserved internal motif sequence in the C-terminal cytoplasmic region of Xenopus membrane-bound receptor Frizzled-4 (Xfz4) that may bind to the conventional peptide binding site in the PDZ domain of the mouse cytoplasmic protein Dishevelled (Dvl) suggesting a role of this conserved motif in the modulation of Wnt signalling |
Record No : 52 |
| Instance ID | 11951 | | Regular Expression | KTxxx[WI] | | Motif Instance | KTLQSW | | Bait Uniprot Accession | Q9PUK8 | | Bait Uniprot Identifier | FZD7A_XENLA | | Bait Gene Name | fzd7-a | | Sequence Position | 527-532 | | Critical Residues | P1; P2; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21951 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10990458 | | Comments | A conserved internal motif sequence in the C-terminal cytoplasmic region of Xenopus membrane-bound receptor Frizzled-7-A (Xfz7-A) that may bind to the conventional peptide binding site in the PDZ domain of the mouse cytoplasmic protein Dishevelled (Dvl) suggesting a role of this conserved motif in the modulation of Wnt signalling |
Record No : 53 |
| Instance ID | 11952 | | Regular Expression | KTxxx[WI] | | Motif Instance | KTLQSW | | Bait Uniprot Accession | Q8AVJ9 | | Bait Uniprot Identifier | FZD7B_XENLA | | Bait Gene Name | fzd7-b | | Sequence Position | 526-531 | | Critical Residues | P1; P2; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; NMR | | Interaction ID | 21952 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10990458, 14636582 | | Comments | A conserved internal motif sequence in the C-terminal cytoplasmic region of Xenopus membrane-bound receptor Frizzled-7-B (Xfz7-B) that binds to the conventional peptide binding site in the PDZ domain of the mouse cytoplasmic protein Dishevelled (Dvl) suggesting a role of this conserved motif in the modulation of Wnt signalling |
Record No : 54 |
| Instance ID | 11953 | | Regular Expression | KTxxx[WI] | | Motif Instance | KTMVSW | | Bait Uniprot Accession | P18537 | | Bait Uniprot Identifier | FRIZ_DROME | | Bait Gene Name | fz | | Sequence Position | 556-561 | | Critical Residues | P1; P2; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21953 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10990458, 19234454 | | Comments | A conserved internal motif sequence in the C-terminal cytoplasmic region of Drosophila membrane-bound receptor Frizzled-1 (dFz1) that may bind to the conventional peptide binding site in the PDZ domain of the cytoplasmic protein Dishevelled (Dvl) suggesting a role of this conserved motif in the modulation of Wnt signalling |
Record No : 55 |
| Instance ID | 11954 | | Regular Expression | KTxxx[WI] | | Motif Instance | KTLESW | | Bait Uniprot Accession | Q9VVX3 | | Bait Uniprot Identifier | FRIZ2_DROME | | Bait Gene Name | fz2 | | Sequence Position | 608-613 | | Critical Residues | P1; P2; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21954 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10990458, 14636582 | | Comments | A conserved internal motif sequence in the C-terminal cytoplasmic region of Drosophila membrane-bound receptor Frizzled-2 (dFz2) that may bind to the conventional peptide binding site in the PDZ domain of the cytoplasmic protein Dishevelled (Dvl) suggesting a role of this conserved motif in the modulation of Wnt signalling |
Record No : 56 |
| Instance ID | 11970 | | Regular Expression | PxxxRxxKP | | Motif Instance | SLPPRNIKP | | Bait Uniprot Accession | O35601 | | Bait Uniprot Identifier | FYB_MOUSE | | Bait Gene Name | Fyb | | Sequence Position | 406-414 | | Critical Residues | P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPOT Analysis | | Interaction ID | 21970 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12176364 | | Comments | The high-affinity atypical R-X-X-K binding motif in mouse FYN-binding protein/SLAP-130 for binding the Gads SH3 Domain |
Record No : 57 |
| Instance ID | 12037 | | Regular Expression | [DE][DE]FEDAx[DE] | | Motif Instance | DDFEDATE | | Bait Uniprot Accession | Q9UNN5 | | Bait Uniprot Identifier | FAF1_HUMAN | | Bait Gene Name | FAF1 | | Sequence Position | 294-301 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22037 | | Interacting Domain | MSP domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24885147 | | Comments | FFAT-like motif in human FAS-associated factor 1 (FAF1) that allows it to interact directly with the MSP domain of human Vesicle-associated membrane protein-associated protein B/C (VAPB) |
Record No : 58 |
| Instance ID | 12192 | | Regular Expression | C[^DENQ][LIVM]x$ | | Motif Instance | CVIL | | Bait Uniprot Accession | Q9UKC9 | | Bait Uniprot Identifier | FBXL2_HUMAN | | Bait Gene Name | FBXL2 | | Sequence Position | 420-423 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22192 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23604317 | | Comments | The C-terminal CaaX motif in human F-box/LRR-repeat protein 2 (FBXL2) that mediates its interaction with human Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) or PI3-kinase subunit p85-alpha |
Record No : 59 |
| Instance ID | 12193 | | Regular Expression | C[^DENQ][LIVM]x$ | | Motif Instance | CVIL | | Bait Uniprot Accession | Q9UKC9 | | Bait Uniprot Identifier | FBXL2_HUMAN | | Bait Gene Name | FBXL2 | | Sequence Position | 420-423 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22193 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23604317 | | Comments | The C-terminal CaaX motif in human F-box/LRR-repeat protein 2 (FBXL2) that mediates its interaction with human Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) or PI3-kinase subunit p85-beta |
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