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Total : 56 Records
Record No : 1 |
| Instance ID | 10049 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RAQSSP | | Bait Uniprot Accession | P56524 | | Bait Uniprot Identifier | HDAC4_HUMAN | | Bait Gene Name | HDAC4 | | Sequence Position | 629-634 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning | | Interaction ID | 20049 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10869435 | | Comments | Phosphoserine-containing 14-3-3 binding motif (pS-632) in human Histone deacetylase 4 that mediates interaction with 14-3-3 protein epsilon and results in the sequestration of HDAC4 in the cytoplasm, wheras loss of this interaction allows HDAC4 to translocate to the nucleus, interact with HDAC3, and repress gene expression |
Record No : 2 |
| Instance ID | 10050 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RAQSSP | | Bait Uniprot Accession | P56524 | | Bait Uniprot Identifier | HDAC4_HUMAN | | Bait Gene Name | HDAC4 | | Sequence Position | 629-634 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning | | Interaction ID | 20050 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10869435 | | Comments | Phosphoserine-containing 14-3-3 binding motif (pS-632) in human Histone deacetylase 4 that mediates interaction with 14-3-3 protein beta and results in the sequestration of HDAC4 in the cytoplasm, wheras loss of this interaction allows HDAC4 to translocate to the nucleus, interact with HDAC3, and repress gene expression |
Record No : 3 |
| Instance ID | 10171 | | Regular Expression | xKENx | | Motif Instance | NKENE | | Bait Uniprot Accession | P34244 | | Bait Uniprot Identifier | HSL1_YEAST | | Bait Gene Name | HSL1 | | Sequence Position | 774-778 | | Critical Residues | P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 20171 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11562348 | | Comments | KEN box motif in budding yeast Hsl1p that is required for APC-mediated degradation and direct binding to Cdh1p |
Record No : 4 |
| Instance ID | 10218 | | Regular Expression | x(S)xxY$ | | Motif Instance | ASQEY | | Bait Uniprot Accession | P16104 | | Bait Uniprot Identifier | H2AX_HUMAN | | Bait Gene Name | H2AFX | | Sequence Position | 139-143 | | Critical Residues | P2; P5 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; ITC; Pull down; Mutation analysis | | Interaction ID | 20218 | | Interacting Domain | BRCT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16377563 | | Comments | MDC1/NFBD1 directly binds to Histone H2AX (gammaH2AX) by specifically interacting with the phosphoepitope at the gammaH2AX carboxyl terminus through its BRCT repeat domain, this interaction playing a central role in the mammalian response to DNA damage |
Record No : 5 |
| Instance ID | 10237 | | Regular Expression | L[IVLMF]x[IVLMF][DE] | | Motif Instance | LMDMD | | Bait Uniprot Accession | O00291 | | Bait Uniprot Identifier | HIP1_HUMAN | | Bait Gene Name | HIP1 | | Sequence Position | 332-336 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Classical fluorescence spectroscopy; Confocal microscopy | | Interaction ID | 20237 | | Interacting Domain | Clathrin propeller repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11577110, 11517213 | | Comments | Clathrin box motif in human Huntingtin-interacting protein 1 that is sufficient for binding to the amino terminal beta propeller structure of Clathrin heavy chain |
Record No : 6 |
| Instance ID | 10242 | | Regular Expression | [DE][DE]xxxVP[DE] | | Motif Instance | EEIRRVPE | | Bait Uniprot Accession | O24646 | | Bait Uniprot Identifier | HY5_ARATH | | Bait Gene Name | HY5 | | Sequence Position | 38-45 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20242 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9659918 | | Comments | Arabidopsis COP1 negatively regulates HY5, a bZIP protein and a positive regulator of photomorphogenic development, through a consensus COP1 binding motif |
Record No : 7 |
| Instance ID | 10260 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | GLDLSK | | Bait Uniprot Accession | Q14526 | | Bait Uniprot Identifier | HIC1_HUMAN | | Bait Gene Name | HIC1 | | Sequence Position | 241-246 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20260 | | Interacting Domain | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12052894 | | Comments | The human candidate tumor suppressor gene HIC1 recruits CtBP through a conserved GLDLSKK/R motif highly related to the consensus CtBP interaction motif (PXDLSXK/R), except for the replacement of the virtually invariant proline by a glycine |
Record No : 8 |
| Instance ID | 10281 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | PLSLV | | Bait Uniprot Accession | P14003 | | Bait Uniprot Identifier | HAIR_DROME | | Bait Gene Name | h | | Sequence Position | 318-322 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20281 | | Interacting Domain | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9524128 | | Comments | Drosophila CtBP interacts specifically and directly with a C-terminal PxDLS motif of the transcriptional repressor hairy (h) |
Record No : 9 |
| Instance ID | 10297 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RKLEL | | Bait Uniprot Accession | P54198 | | Bait Uniprot Identifier | HIRA_HUMAN | | Bait Gene Name | HIRA | | Sequence Position | 629-633 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding | | Interaction ID | 20297 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11238922 | | Comments | The RXL motif of HIRA, the human homologue of yeast Hir1p and Hir2p, that directs binding to cyclin A |
Record No : 10 |
| Instance ID | 10407 | | Regular Expression | x[FYH]x[IVM][^WFYP][^WFYP][ILM][ILMV]x | | Motif Instance | SYSIHSLLG | | Bait Uniprot Accession | Q02308 | | Bait Uniprot Identifier | HLES_DROME | | Bait Gene Name | H | | Sequence Position | 662-670 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Pull down | | Interaction ID | 20407 | | Interacting Domain | WD domain, G-beta repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16287856, 12154126 | | Comments | The eh1 motif in Drosophila Protein hairless (H) that binds to the WD40 domain of the Groucho corepressor |
Record No : 11 |
| Instance ID | 10455 | | Regular Expression | [DE]HxY | | Motif Instance | DHPY | | Bait Uniprot Accession | Q9NWW0 | | Bait Uniprot Identifier | HPIP_HUMAN | | Bait Gene Name | HCFC1R1 | | Sequence Position | 76-79 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Mutation analysis | | Interaction ID | 20455 | | Interacting Domain | Galactose oxidase, central domain | | Disease Association(s) | Herpes simplex virus (HSV) infection | | Inhibitor(s) | Unknown | | Reference(s) | 12235138 | | Comments | Interaction of human Host cell factor 1 (HCF-1) with a HCF-1 beta-propeller domain binding protein, termed HPIP, mediated by a HCF-binding motif or HBM in HPIP, through which HPIP regulates HCF-1 activity by modulating its subcellular localization |
Record No : 12 |
| Instance ID | 10466 | | Regular Expression | [FY][DEP]WM | | Motif Instance | FDWM | | Bait Uniprot Accession | P14653 | | Bait Uniprot Identifier | HXB1_HUMAN | | Bait Gene Name | HOXB1 | | Sequence Position | 180-183 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20466 | | Interacting Domain | Homeobox domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10052460 | | Comments | The YPWM motif in human Homeobox protein Hox-B1 that confers binding to Homeobox protein PBX1 suggesting the modulation of Hox DNA binding activity by Pbx1 |
Record No : 13 |
| Instance ID | 10571 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | RLCRLLR | | Bait Uniprot Accession | O43593 | | Bait Uniprot Identifier | HAIR_HUMAN | | Bait Gene Name | HR | | Sequence Position | 565-571 | | Critical Residues | P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; Y2H; Co-IP; Pull down(GST tag) | | Interaction ID | 20571 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12215540 | | Comments | The NR box motif (565-571) of human product of the thyroid hormone-regulated mammalian gene hairless (HR) that is necessary for binding the human Nuclear receptor ROR-alpha (RORA) |
Record No : 14 |
| Instance ID | 10572 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | SLCELLA | | Bait Uniprot Accession | O43593 | | Bait Uniprot Identifier | HAIR_HUMAN | | Bait Gene Name | HR | | Sequence Position | 757-763 | | Critical Residues | P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; Y2H; Co-IP; Pull down(GST tag) | | Interaction ID | 20572 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12215540 | | Comments | The NR box motif (757-763) of human product of the thyroid hormone-regulated mammalian gene hairless (HR) that is necessary for binding the human Nuclear receptor ROR-alpha (RORA) |
Record No : 15 |
| Instance ID | 10580 | | Regular Expression | [IL]A(P)x{6,8}[FLIVM]x[FLIVM] | | Motif Instance | LAPYIPMDDDFQL | | Bait Uniprot Accession | Q16665 | | Bait Uniprot Identifier | HIF1A_HUMAN | | Bait Gene Name | HIF1A | | Sequence Position | 562-574 | | Critical Residues | P3 | | Motif PTM(s) | Hydroxylation at Pro-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; ITC; SPR | | Interaction ID | 20580 | | Interacting Domain | VHL beta domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12050673, 12004076 | | Comments | In normoxia, human Hypoxia-inducible factor 1-alpha (HIF1A) is hydroxylated at Pro-564 to promote interaction with Von Hippel-Lindau disease tumor suppressor protein (VHL) which leads to ubiquitination and proteasomal degradation |
Record No : 16 |
| Instance ID | 10581 | | Regular Expression | [IL]A(P)x{6,8}[FLIVM]x[FLIVM] | | Motif Instance | LAPAAGDTIISLDF | | Bait Uniprot Accession | Q16665 | | Bait Uniprot Identifier | HIF1A_HUMAN | | Bait Gene Name | HIF1A | | Sequence Position | 400-413 | | Critical Residues | P3 | | Motif PTM(s) | Hydroxylation at Pro-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 20581 | | Interacting Domain | VHL beta domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12050673 | | Comments | In normoxia, human Hypoxia-inducible factor 1-alpha (HIF1A) is hydroxylated at Pro-402 to promote interaction with Von Hippel-Lindau disease tumor suppressor protein (VHL) which leads to ubiquitination and proteasomal degradation |
Record No : 17 |
| Instance ID | 10582 | | Regular Expression | [IL]A(P)x{6,8}[FLIVM]x[FLIVM] | | Motif Instance | LAPYISMDDDFQL | | Bait Uniprot Accession | Q9Y2N7 | | Bait Uniprot Identifier | HIF3A_HUMAN | | Bait Gene Name | HIF3A | | Sequence Position | 490-502 | | Critical Residues | P3 | | Motif PTM(s) | Hydroxylation at Pro-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Sequence based prediction | | Interaction ID | 20582 | | Interacting Domain | VHL beta domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12538644 | | Comments | Human Hypoxia-inducible factor 3-alpha (HIF3A) 1-3 splice variants is targeted for ubiquitylation by the pVHL complex by hydroxylation of Pro-492 to promote interaction with Von Hippel-Lindau disease tumor suppressor protein (VHL) |
Record No : 18 |
| Instance ID | 10664 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | SLESCF | | Bait Uniprot Accession | P97288 | | Bait Uniprot Identifier | 5HT4R_MOUSE | | Bait Gene Name | Htr4 | | Sequence Position | 382-387 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Affinity chromatography technology; Co-IP; Confocal microscopy; Mutation analysis | | Interaction ID | 20664 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15466885 | | Comments | C-terminal class 1 PDZ-binding motif in mouse 5-hydroxytryptamine receptor 4 (Htr4) that binds to the PDZ domain of mouse Sorting nexin-27 (Snx27) |
Record No : 19 |
| Instance ID | 10686 | | Regular Expression | xxx[VLIFY]x[ACVILF]$ | | Motif Instance | NRPVPV | | Bait Uniprot Accession | P97288 | | Bait Uniprot Identifier | 5HT4R_MOUSE | | Bait Gene Name | Htr4 | | Sequence Position | 366-371 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Affinity chromatography technology; Confocal microscopy; Mutation analysis | | Interaction ID | 20686 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15466885 | | Comments | The Class 2 PDZ-binding motif of Isoform 5-HT4(E) of mouse 5-hydroxytryptamine receptor 4 (Htr4) that binds to the PDZ domain of mouse Inadl/Cipp |
Record No : 20 |
| Instance ID | 10734 | | Regular Expression | xP[TS]APx | | Motif Instance | TPSAPV | | Bait Uniprot Accession | O14964 | | Bait Uniprot Identifier | HGS_HUMAN | | Bait Gene Name | HGS | | Sequence Position | 347-352 | | Critical Residues | P2; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Mutation analysis | | Interaction ID | 20734 | | Interacting Domain | UEV domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21070952, 12802020 | | Comments | The UEV Domain binding P[TS]AP motif in Human Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/HRS) that mediates binding to the UEV domain of human ESCRT-I complex subunit TSG101 |
Record No : 21 |
| Instance ID | 10961 | | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | | Motif Instance | VSVIT | | Bait Uniprot Accession | Q9H2X6 | | Bait Uniprot Identifier | HIPK2_HUMAN | | Bait Gene Name | HIPK2 | | Sequence Position | 885-889 | | Critical Residues | P1; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Pull down; Co-IP; Mutation analysis | | Interaction ID | 20961 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21192925, 12565818 | | Comments | The SUMO-interacting motif (SIM) of human Homeodomain-interacting protein kinase 2 (HIPK2) that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1) |
Record No : 22 |
| Instance ID | 11013 | | Regular Expression | EEVD | | Motif Instance | EEVD | | Bait Uniprot Accession | P07900 | | Bait Uniprot Identifier | HS90A_HUMAN | | Bait Gene Name | HSP90AA1 | | Sequence Position | 729-732 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | NMR; X-ray crystallography; Alanine scanning; Mutation analysis | | Interaction ID | 21013 | | Interacting Domain | Tetratricopeptide repeat (TPR) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16531226, 10786835, 11877417, 10567422 | | Comments | The C-terminal sequence EEVD in human Heat shock protein HSP 90-alpha (HSP90AA1) that binds to the TPR (tetratricopeptide repeat) domain of human Stress-induced-phosphoprotein 1 (STIP1)/ Hsc70/Hsp90-organizing protein (Hop) |
Record No : 23 |
| Instance ID | 11197 | | Regular Expression | [WFY]RP[WFY]x{0,7}$ | | Motif Instance | WRPWRN | | Bait Uniprot Accession | Q14469 | | Bait Uniprot Identifier | HES1_HUMAN | | Bait Gene Name | HES1 | | Sequence Position | 275-280 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 21197 | | Interacting Domain | WD domain, G-beta repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12972610 | | Comments | The interaction of human Transcription factor HES-1 with the human transcriptional co-repressor Transducin-like enhancer protein 1 (TLE1) is mediated by a WRPW tetrapeptide motif in HES-1 |
Record No : 24 |
| Instance ID | 11234 | | Regular Expression | [ST]x[VL]D | | Motif Instance | TNLD | | Bait Uniprot Accession | O43719 | | Bait Uniprot Identifier | HTSF1_HUMAN | | Bait Gene Name | HTATSF1 | | Sequence Position | 4-7 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21234 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22876914 | | Comments | Novel internal motif identified in human HIV Tat-specific factor 1 (HTATSF1) that is recognized by human Glutaminase-interacting protein (GIP), also known as Tax-interacting protein 1 (TIP1) or Tax1-binding protein 3 (TAX1BP3), composed almost exclusively of a single PDZ domain |
Record No : 25 |
| Instance ID | 11332 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | TKQTQTF | | Bait Uniprot Accession | P63018 | | Bait Uniprot Identifier | HSP7C_RAT | | Bait Gene Name | Hspa8 | | Sequence Position | 422-428 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21332 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in rat Heat shock 70 kDa protein 8 (Hspa8) that interacts with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8) |
Record No : 26 |
| Instance ID | 11333 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | TKQTQTF | | Bait Uniprot Accession | P63018 | | Bait Uniprot Identifier | HSP7C_RAT | | Bait Gene Name | Hspa8 | | Sequence Position | 422-428 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21333 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in rat Heat shock 70 kDa protein 8 (Hspa8) that interacts with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2) |
Record No : 27 |
| Instance ID | 11565 | | Regular Expression | [ST]x[VLI]$ | | Motif Instance | SSV | | Bait Uniprot Accession | P28335 | | Bait Uniprot Identifier | 5HT2C_HUMAN | | Bait Gene Name | HTR2C | | Sequence Position | 456-458 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 21565 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9537516 | | Comments | C-terminus of the human 5-HT2C receptor that may interact with PDZ domains of human Multi-PDZ domain protein 1 (MUPP1) or MPDZ |
Record No : 28 |
| Instance ID | 11805 | | Regular Expression | [LI]xCxE | | Motif Instance | IACEE | | Bait Uniprot Accession | Q13547 | | Bait Uniprot Identifier | HDAC1_HUMAN | | Bait Gene Name | HDAC1 | | Sequence Position | 414-418 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21805 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9468140 | | Comments | The Rb-binding LXCXE or IXCXE motif of the human Histone deacetylase 1 that binds the A/B pocket of human Retinoblastoma-associated protein (RB1) and is involved in transcriptional repression by Rb |
Record No : 29 |
| Instance ID | 11897 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | FDWMK | | Bait Uniprot Accession | P09022 | | Bait Uniprot Identifier | HXA1_MOUSE | | Bait Gene Name | Hoxa1 | | Sequence Position | 201-205 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21897 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7565734, 8600458 | | Comments | The highly conserved pentapeptide motif in mouse Hoxa1 that is essential for cooperative DNA binding with Pbx1 |
Record No : 30 |
| Instance ID | 11898 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | FDWMK | | Bait Uniprot Accession | P17919 | | Bait Uniprot Identifier | HXB1_MOUSE | | Bait Gene Name | Hoxb1 | | Sequence Position | 176-180 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Mutational analysis | | Interaction ID | 21898 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7565734, 8600458, 10052460 | | Comments | The highly conserved pentapeptide motif in mouse Hoxb1 that is essential for cooperative DNA binding with Pbx1 |
Record No : 31 |
| Instance ID | 11899 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | FEWMK | | Bait Uniprot Accession | Q01822 | | Bait Uniprot Identifier | HXD1_MOUSE | | Bait Gene Name | Hoxd1 | | Sequence Position | 205-209 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21899 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7565734, 8600458 | | Comments | The highly conserved pentapeptide motif in mouse Hoxd1 that is essential for cooperative DNA binding with Pbx1 |
Record No : 32 |
| Instance ID | 11900 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | YPWMK | | Bait Uniprot Accession | P31245 | | Bait Uniprot Identifier | HXA2_MOUSE | | Bait Gene Name | Hoxa2 | | Sequence Position | 97-101 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21900 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7565734, 8600458 | | Comments | The highly conserved pentapeptide motif in mouse Hoxa2 that is essential for cooperative DNA binding with Pbx1 |
Record No : 33 |
| Instance ID | 11901 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | FPWMK | | Bait Uniprot Accession | P0C1T1 | | Bait Uniprot Identifier | HXB2_MOUSE | | Bait Gene Name | Hoxb2 | | Sequence Position | 93-97 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21901 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7565734, 8600458 | | Comments | The highly conserved pentapeptide motif in mouse Hoxb2 that is essential for cooperative DNA binding with Pbx1 |
Record No : 34 |
| Instance ID | 11902 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | FPWMK | | Bait Uniprot Accession | P09026 | | Bait Uniprot Identifier | HXB3_MOUSE | | Bait Gene Name | Hoxb3 | | Sequence Position | 130-134 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21902 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7565734, 8600458 | | Comments | The highly conserved pentapeptide motif in mouse Hoxb3 that is essential for cooperative DNA binding with Pbx1 |
Record No : 35 |
| Instance ID | 11903 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | FPWMK | | Bait Uniprot Accession | P09027 | | Bait Uniprot Identifier | HXD3_MOUSE | | Bait Gene Name | Hoxd3 | | Sequence Position | 162-166 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21903 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7565734, 8600458 | | Comments | The highly conserved pentapeptide motif in mouse Hoxd3 that is essential for cooperative DNA binding with Pbx1 |
Record No : 36 |
| Instance ID | 11904 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | YPWMK | | Bait Uniprot Accession | P06798 | | Bait Uniprot Identifier | HXA4_MOUSE | | Bait Gene Name | Hoxa4 | | Sequence Position | 160-164 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21904 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7565734, 8600458 | | Comments | The highly conserved pentapeptide motif in mouse Hoxa4 that is essential for cooperative DNA binding with Pbx1 |
Record No : 37 |
| Instance ID | 11905 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | YPWMR | | Bait Uniprot Accession | P10284 | | Bait Uniprot Identifier | HXB4_MOUSE | | Bait Gene Name | Hoxb4 | | Sequence Position | 141-145 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21905 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7565734, 8600458 | | Comments | The highly conserved pentapeptide motif in mouse Hoxb4 that is essential for cooperative DNA binding with Pbx1 |
Record No : 38 |
| Instance ID | 11906 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | YPWMK | | Bait Uniprot Accession | Q08624 | | Bait Uniprot Identifier | HXC4_MOUSE | | Bait Gene Name | Hoxc4 | | Sequence Position | 136-140 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21906 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7565734, 8600458 | | Comments | The highly conserved pentapeptide motif in mouse Hoxc4 that is essential for cooperative DNA binding with Pbx1 |
Record No : 39 |
| Instance ID | 11907 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | YPWMK | | Bait Uniprot Accession | P10628 | | Bait Uniprot Identifier | HXD4_MOUSE | | Bait Gene Name | Hoxd4 | | Sequence Position | 132-136 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21907 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7565734, 8600458 | | Comments | The highly conserved pentapeptide motif in mouse Hoxd4 that is essential for cooperative DNA binding with Pbx1 |
Record No : 40 |
| Instance ID | 11908 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | YPWMR | | Bait Uniprot Accession | P09021 | | Bait Uniprot Identifier | HXA5_MOUSE | | Bait Gene Name | Hoxa5 | | Sequence Position | 177-181 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21908 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7565734, 8600458 | | Comments | The highly conserved pentapeptide motif in mouse Hoxa5 that is essential for cooperative DNA binding with Pbx1 |
Record No : 41 |
| Instance ID | 11909 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | FPWMR | | Bait Uniprot Accession | P09079 | | Bait Uniprot Identifier | HXB5_MOUSE | | Bait Gene Name | Hoxb5 | | Sequence Position | 177-181 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21909 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7565734, 8600458 | | Comments | The highly conserved pentapeptide motif in mouse Hoxb5 that is essential for cooperative DNA binding with Pbx1 |
Record No : 42 |
| Instance ID | 11910 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | YPWMR | | Bait Uniprot Accession | P02830 | | Bait Uniprot Identifier | HXA7_MOUSE | | Bait Gene Name | Hoxa7 | | Sequence Position | 119-123 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21910 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7565734, 8600458 | | Comments | The highly conserved pentapeptide motif in mouse Hoxa7 that is essential for cooperative DNA binding with Pbx1 |
Record No : 43 |
| Instance ID | 11911 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | YPWMR | | Bait Uniprot Accession | P09024 | | Bait Uniprot Identifier | HXB7_MOUSE | | Bait Gene Name | Hoxb7 | | Sequence Position | 127-131 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21911 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7565734, 8600458 | | Comments | The highly conserved pentapeptide motif in mouse Hoxb7 that is essential for cooperative DNA binding with Pbx1 |
Record No : 44 |
| Instance ID | 11912 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | FPWMR | | Bait Uniprot Accession | P09632 | | Bait Uniprot Identifier | HXB8_MOUSE | | Bait Gene Name | Hoxb8 | | Sequence Position | 135-139 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21912 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7565734, 8600458 | | Comments | The highly conserved pentapeptide motif in mouse Hoxb8 that is essential for cooperative DNA binding with Pbx1 |
Record No : 45 |
| Instance ID | 11913 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | FPWMR | | Bait Uniprot Accession | P09025 | | Bait Uniprot Identifier | HXC8_MOUSE | | Bait Gene Name | Hoxc8 | | Sequence Position | 139-143 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21913 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7565734, 8600458 | | Comments | The highly conserved pentapeptide motif in mouse Hoxc8 that is essential for cooperative DNA binding with Pbx1 |
Record No : 46 |
| Instance ID | 11914 | | Regular Expression | [FY]PWM[KR] | | Motif Instance | FPWMR | | Bait Uniprot Accession | P23463 | | Bait Uniprot Identifier | HXD8_MOUSE | | Bait Gene Name | Hoxd8 | | Sequence Position | 184-188 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21914 | | Interacting Domain | Homeodomain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7565734, 8600458 | | Comments | The highly conserved pentapeptide motif in mouse Hoxd8 that is essential for cooperative DNA binding with Pbx1 |
Record No : 47 |
| Instance ID | 11955 | | Regular Expression | PxLPx[IL] | | Motif Instance | PSLPNI | | Bait Uniprot Accession | P56524 | | Bait Uniprot Identifier | HDAC4_HUMAN | | Bait Gene Name | HDAC4 | | Sequence Position | 349-354 | | Critical Residues | P1; P3; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Peptide array binding assay; Mutational analysis; ITC | | Interaction ID | 21955 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22649097, 15964851 | | Comments | The PxLPxI/L motif of human Histone deacetylase 4 recognized by Ankyrin repeat family A protein 2 (ANKRA2) for signal-dependent binding to the ankyrin repeat domain |
Record No : 48 |
| Instance ID | 11956 | | Regular Expression | PxLPx[IL] | | Motif Instance | PSLPNI | | Bait Uniprot Accession | Q9UQL6 | | Bait Uniprot Identifier | HDAC5_HUMAN | | Bait Gene Name | HDAC5 | | Sequence Position | 367-372 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21956 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22649097, 15964851 | | Comments | The PxLPxI/L motif of human Histone deacetylase 5 recognized by Ankyrin repeat family A protein 2 (ANKRA2) for signal-dependent binding to the ankyrin repeat domain |
Record No : 49 |
| Instance ID | 11960 | | Regular Expression | PxLPx[IL] | | Motif Instance | PSLPNI | | Bait Uniprot Accession | P56524 | | Bait Uniprot Identifier | HDAC4_HUMAN | | Bait Gene Name | HDAC4 | | Sequence Position | 349-354 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; ITC | | Interaction ID | 21960 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22649097, 15964851 | | Comments | The PxLPxI/L motif of human Histone deacetylase 4 recognized by Regulatory factor X-associated ankyrin-containing protein (RFXANK, also known as ANKRA1 and RFX-B) for binding to the ankyrin repeat domain |
Record No : 50 |
| Instance ID | 11961 | | Regular Expression | PxLPx[IL] | | Motif Instance | PSLPNI | | Bait Uniprot Accession | Q9UQL6 | | Bait Uniprot Identifier | HDAC5_HUMAN | | Bait Gene Name | HDAC5 | | Sequence Position | 367-372 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21961 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22649097, 15964851 | | Comments | The PxLPxI/L motif of human Histone deacetylase 5 recognized by Regulatory factor X-associated ankyrin-containing protein (RFXANK, also known as ANKRA1 and RFX-B) for binding to the ankyrin repeat domain |
Record No : 51 |
| Instance ID | 11990 | | Regular Expression | EEVD | | Motif Instance | EEVD | | Bait Uniprot Accession | P11142 | | Bait Uniprot Identifier | HSP7C_HUMAN | | Bait Gene Name | HSPA8 | | Sequence Position | 643-646 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; ITC; SPR; Competition binding | | Interaction ID | 21990 | | Interacting Domain | Tetratricopeptide repeat (TPR) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11877417, 19586912 | | Comments | The C-terminal sequence EEVD in human Heat shock cognate 71 kDa protein (HSPA8/HSC70) that binds to the TPR2A domain of human Stress-induced-phosphoprotein 1 (STIP1)/ Hsc70/Hsp90-organizing protein (Hop) |
Record No : 52 |
| Instance ID | 12023 | | Regular Expression | HPD | | Motif Instance | HPD | | Bait Uniprot Accession | P0A6L9 | | Bait Uniprot Identifier | HSCB_ECOLI | | Bait Gene Name | hscB | | Sequence Position | 32-34 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; NMR | | Interaction ID | 22023 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25080945 | | Comments | ATP-/ADP-dependent interactions between Escherichia coli HscA and HscB, the specialized Hsp70/Hsp40 molecular chaperones that mediate iron-sulfur cluster transfer, involve the HPD motif in the J-domain of HscB that directly interacts with ATP-bound HscA |
Record No : 53 |
| Instance ID | 12028 | | Regular Expression | x[DEKR]x[ACVILFM]$ | | Motif Instance | GRRF | | Bait Uniprot Accession | P09651 | | Bait Uniprot Identifier | ROA1_HUMAN | | Bait Gene Name | HNRNPA1 | | Sequence Position | 369-372 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | ELISA; Pull down | | Interaction ID | 22028 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25009770 | | Comments | The carboxy-terminal PDZ binding motif of human Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) that interacts with the human 26S proteasome non-ATPase regulatory subunit 9 (PSMD9) |
Record No : 54 |
| Instance ID | 12182 | | Regular Expression | Q[LVIF]xLPL | | Motif Instance | QLSLPL | | Bait Uniprot Accession | P69931 | | Bait Uniprot Identifier | HDA_ECOLI | | Bait Gene Name | hda | | Sequence Position | 6-11 | | Critical Residues | P2; P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Pull down | | Interaction ID | 22182 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15150238 | | Comments | In Escherichia coli, interactions between the Chromosomal replication initiator protein DnaA, the beta subunit of DNA polymerase III (the sliding clamp protein), and the DnaA regulatory inactivator Hda, are required to convert the active ATP-bound form of DnaA to an inactive ADP-bound form through the accelerated hydrolysis of ATP and is mediated by the beta-binding hexapeptide motif in the amino terminus of Hda |
Record No : 55 |
| Instance ID | 12183 | | Regular Expression | Q[LVIF]xLPL | | Motif Instance | QFKLPL | | Bait Uniprot Accession | B8GW56 | | Bait Uniprot Identifier | B8GW56_CAUCN | | Bait Gene Name | hdaA | | Sequence Position | 4-9 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; FRET | | Interaction ID | 22183 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23974073 | | Comments | The beta-binding hexapeptide motif in the N-terminal region of the Chromosome replication regulator protein HdaA of Caulobacter crescentus that interacts with the DNA polymerase III subunit beta (DnaN) |
Record No : 56 |
| Instance ID | 12199 | | Regular Expression | EEVD | | Motif Instance | EEVD | | Bait Uniprot Accession | P08107 | | Bait Uniprot Identifier | HSP71_HUMAN | | Bait Gene Name | HSPA1A | | Sequence Position | 638-641 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22199 | | Interacting Domain | Ankyrin repeat-containing domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24338975 | | Comments | The EEVD sequence of Heat shock 70 kDa protein 1A/1B (HSPA1A) that binds to the Ankyrin repeat-containing domain of human Gankyrin/ 26S proteasome non-ATPase regulatory subunit 10 (PSMD10) |
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