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Total : 81 Records
Record No : 1 |
| Instance ID | 10043 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | HSRSIP | | Bait Uniprot Accession | P35568 | | Bait Uniprot Identifier | IRS1_HUMAN | | Bait Gene Name | IRS1 | | Sequence Position | 371-376 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding | | Interaction ID | 20043 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312143 | | Comments | Phosphoserine-containing 14-3-3 binding motif (pS-374) in human Insulin receptor substrate 1 that binds to 14-3-3 protein epsilon, which may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1 |
Record No : 2 |
| Instance ID | 10044 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | HSRSIP | | Bait Uniprot Accession | P35568 | | Bait Uniprot Identifier | IRS1_HUMAN | | Bait Gene Name | IRS1 | | Sequence Position | 371-376 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding | | Interaction ID | 20044 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312143 | | Comments | Phosphoserine-containing 14-3-3 binding motif (pS-374) in human Insulin receptor substrate 1 that binds to 14-3-3 protein zeta, which may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1 |
Record No : 3 |
| Instance ID | 10045 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | KSVSAP | | Bait Uniprot Accession | P35568 | | Bait Uniprot Identifier | IRS1_HUMAN | | Bait Gene Name | IRS1 | | Sequence Position | 638-643 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding | | Interaction ID | 20045 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312143 | | Comments | Phosphoserine-containing 14-3-3 binding motif (pS-641) in human Insulin receptor substrate 1 that binds to 14-3-3 protein epsilon, which may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1 |
Record No : 4 |
| Instance ID | 10046 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | KSVSAP | | Bait Uniprot Accession | P35568 | | Bait Uniprot Identifier | IRS1_HUMAN | | Bait Gene Name | IRS1 | | Sequence Position | 638-643 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding | | Interaction ID | 20046 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312143 | | Comments | Phosphoserine-containing 14-3-3 binding motif (pS-641) in human Insulin receptor substrate 1 that binds to 14-3-3 protein zeta, which may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1 |
Record No : 5 |
| Instance ID | 10047 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSKSQS | | Bait Uniprot Accession | P35568 | | Bait Uniprot Identifier | IRS1_HUMAN | | Bait Gene Name | IRS1 | | Sequence Position | 267-272 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20047 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312143 | | Comments | Phosphoserine-containing 14-3-3 binding motif (pS-270) in human Insulin receptor substrate 1 that binds to 14-3-3 protein epsilon, which may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1 |
Record No : 6 |
| Instance ID | 10048 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSKSQS | | Bait Uniprot Accession | P35568 | | Bait Uniprot Identifier | IRS1_HUMAN | | Bait Gene Name | IRS1 | | Sequence Position | 267-272 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20048 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9312143 | | Comments | Phosphoserine-containing 14-3-3 binding motif (pS-270) in human Insulin receptor substrate 1 that binds to 14-3-3 protein zeta, which may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1 |
Record No : 7 |
| Instance ID | 10061 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | KSATTT | | Bait Uniprot Accession | P05107 | | Bait Uniprot Identifier | ITB2_HUMAN | | Bait Gene Name | ITGB2 | | Sequence Position | 755-760 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; SPR; X-ray crystallography; Pull down | | Interaction ID | 20061 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18550856 | | Comments | Beta2 integrin phosphorylation on cytoplasmic Thr758 acts as a molecular switch to inhibit filamin binding and allow 14-3-3 protein zeta binding to the integrin cytoplasmic domain, thereby modulating T-cell adhesion |
Record No : 8 |
| Instance ID | 10158 | | Regular Expression | xRxxLxx[LIVM]x | | Motif Instance | SRTPLTTLN | | Bait Uniprot Accession | Q02363 | | Bait Uniprot Identifier | ID2_HUMAN | | Bait Gene Name | ID2 | | Sequence Position | 99-107 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20158 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16810178 | | Comments | APCC-binding Destruction motif (DBox) in human DNA-binding protein inhibitor ID-2 recognised by Cdh1, co-activator protein for the anaphase-promoting ubiquitin ligase complex APC/C |
Record No : 9 |
| Instance ID | 10203 | | Regular Expression | DAxPx | | Motif Instance | DAAPV | | Bait Uniprot Accession | Q7K4Z4 | | Bait Uniprot Identifier | Q7K4Z4_DROME | | Bait Gene Name | imd | | Sequence Position | 30-34 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20203 | | Interacting Domain | BIR domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20122400 | | Comments | IAP-binding motif in Drosophila imd protein that preferentially binds to the BIR2 domain of Drosophila Iap2 (dIAP2) |
Record No : 10 |
| Instance ID | 10210 | | Regular Expression | DAxGx | | Motif Instance | DALGS | | Bait Uniprot Accession | O01382 | | Bait Uniprot Identifier | ICE_DROME | | Bait Gene Name | Ice | | Sequence Position | 28-32 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20210 | | Interacting Domain | BIR domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15580265 | | Comments | IAP-binding motif in Drosophila effector caspase drICE that binds to the BIR1 domain of Drosophila IAP1 (dIAP1) |
Record No : 11 |
| Instance ID | 10278 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | PEDLA | | Bait Uniprot Accession | Q9H2S9 | | Bait Uniprot Identifier | IKZF4_HUMAN | | Bait Gene Name | IKZF4 | | Sequence Position | 425-429 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20278 | | Interacting Domain | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12444977 | | Comments | Ikaros family zinc finger protein Eos contains a PXDLS CtBP contact motif within its repression domain for binding to murine CtBP2 |
Record No : 12 |
| Instance ID | 10283 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | PEDLS | | Bait Uniprot Accession | Q13422 | | Bait Uniprot Identifier | IKZF1_HUMAN | | Bait Gene Name | IKZF1 | | Sequence Position | 34-38 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20283 | | Interacting Domain | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10766745 | | Comments | CtBP interacts with human DNA-binding protein Ikaros through a PEDLS motif present at the N terminus of Ikaros |
Record No : 13 |
| Instance ID | 10298 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RSLKL | | Bait Uniprot Accession | Q13352 | | Bait Uniprot Identifier | CENPR_HUMAN | | Bait Gene Name | ITGB3BP | | Sequence Position | 5-9 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20298 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10673397 | | Comments | The cyclin-binding RxL motif in human Beta-3-endonexin or Centromere protein R (Centromere protein R) through which it specifically binds cyclin A |
Record No : 14 |
| Instance ID | 10380 | | Regular Expression | xNPFx | | Motif Instance | PNPFV | | Bait Uniprot Accession | P40559 | | Bait Uniprot Identifier | INP51_YEAST | | Bait Gene Name | INP51 | | Sequence Position | 931-935 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20380 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15265867 | | Comments | INP51 associates with the EH Domain-containing protein TAX4 via its NPF motif in Saccharomyces cerevisiae |
Record No : 15 |
| Instance ID | 10381 | | Regular Expression | xNPFx | | Motif Instance | PNPFV | | Bait Uniprot Accession | P40559 | | Bait Uniprot Identifier | INP51_YEAST | | Bait Gene Name | INP51 | | Sequence Position | 931-935 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20381 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15265867 | | Comments | INP51 associates with the EH Domain-containing protein IRS4 via its NPF motif in Saccharomyces cerevisiae |
Record No : 16 |
| Instance ID | 10421 | | Regular Expression | ([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P) | | Motif Instance | WPPPP | | Bait Uniprot Accession | P51617 | | Bait Uniprot Identifier | IRAK1_HUMAN | | Bait Gene Name | IRAK1 | | Sequence Position | 168-172 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP; Western blot | | Interaction ID | 20421 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20044140 | | Comments | Proline-rich motif within human Interleukin-1 receptor-associated kinase 1 (IRAK-1) that is required for its interaction with VASP |
Record No : 17 |
| Instance ID | 10445 | | Regular Expression | PPxxF | | Motif Instance | PPKKF | | Bait Uniprot Accession | Q14643 | | Bait Uniprot Identifier | ITPR1_HUMAN | | Bait Gene Name | ITPR1 | | Sequence Position | 49-53 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot | | Interaction ID | 20445 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9808459 | | Comments | Proline-rich motif in human IP3 receptor isoform 1 that is recognized by Class II EVH1 domain of Homer1 |
Record No : 18 |
| Instance ID | 10478 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | KDEVVKIQSLARMHQARKRY | | Bait Uniprot Accession | P46940 | | Bait Uniprot Identifier | IQGA1_HUMAN | | Bait Gene Name | IQGAP1 | | Sequence Position | 806-825 | | Critical Residues | P7; P8; P12; P17 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20478 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12446675 | | Comments | Interaction of Calmodulin (CALM1) with the IQ motif (806-825) of human Ras GTPase-activating-like protein IQGAP1 |
Record No : 19 |
| Instance ID | 10479 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | INDIIKIQAFIRANKARDD | | Bait Uniprot Accession | P46940 | | Bait Uniprot Identifier | IQGA1_HUMAN | | Bait Gene Name | IQGAP1 | | Sequence Position | 836-854 | | Critical Residues | P7; P8; P12; P17 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20479 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12446675 | | Comments | Interaction of Calmodulin (CALM1) with the IQ motif (836-854) of human Ras GTPase-activating-like protein IQGAP1 |
Record No : 20 |
| Instance ID | 10499 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | DIAAFKIQAVYKGYKVRKAF | | Bait Uniprot Accession | O89019 | | Bait Uniprot Identifier | INVS_MOUSE | | Bait Gene Name | Invs | | Sequence Position | 556-575 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Far Western blotting | | Interaction ID | 20499 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11737147 | | Comments | The Calmodulin binding IQ motif (IQ1:556-575) of the mouse Inversin that binds to the apo C-domain of mouse Calmodulin (CaM) |
Record No : 21 |
| Instance ID | 10500 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | NKAAAVIQRAWRSYQLRKHL | | Bait Uniprot Accession | O89019 | | Bait Uniprot Identifier | INVS_MOUSE | | Bait Gene Name | Invs | | Sequence Position | 915-934 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; Y2H; Far Western blotting | | Interaction ID | 20500 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11737147 | | Comments | The Calmodulin binding IQ motif (IQ2:915-934) of the mouse Inversin that binds to the apo C-domain of mouse Calmodulin (CaM) |
Record No : 22 |
| Instance ID | 10638 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | LEDSVF | | Bait Uniprot Accession | Q01344 | | Bait Uniprot Identifier | IL5RA_HUMAN | | Bait Gene Name | IL5RA | | Sequence Position | 415-420 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | SPR; Co-IP; Y2H; Pull down; Mutation analysis; X-ray crystallography | | Interaction ID | 20638 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11498591, 12842047 | | Comments | Human Syntenin-1 (SDCBP), a protein containing PDZ domains, associates with the class 1 PDZ-binding motif in the cytoplasmic tail of human Interleukin-5 receptor subunit alpha (IL5RA) |
Record No : 23 |
| Instance ID | 10738 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | TGENPIYK | | Bait Uniprot Accession | P05556 | | Bait Uniprot Identifier | ITB1_HUMAN | | Bait Gene Name | ITGB1 | | Sequence Position | 777-784 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20738 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12606711 | | Comments | The NPxY motif (777-784) in human Integrin beta-1 (ITGB1) that mediates its interaction with the phosphotyrosine-binding (PTB) domain of mouse Disabled homolog 1 (Dab1) |
Record No : 24 |
| Instance ID | 10739 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | TGENPIYK | | Bait Uniprot Accession | P05556 | | Bait Uniprot Identifier | ITB1_HUMAN | | Bait Gene Name | ITGB1 | | Sequence Position | 777-784 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20739 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12606711 | | Comments | The NPxY motif (777-784) in human Integrin beta-1 (ITGB1) that mediates its interaction with the phosphotyrosine-binding (PTB) domain of human Epidermal growth factor receptor kinase substrate 8 (EPS8) |
Record No : 25 |
| Instance ID | 10740 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | TGENPIYK | | Bait Uniprot Accession | P05556 | | Bait Uniprot Identifier | ITB1_HUMAN | | Bait Gene Name | ITGB1 | | Sequence Position | 777-784 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20740 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12606711 | | Comments | The NPxY motif (777-784) in human Integrin beta-1 (ITGB1) that mediates its interaction with the phosphotyrosine-binding (PTB) domain of mouse Talin-1 (Tln1) |
Record No : 26 |
| Instance ID | 10741 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | QDSNPLYK | | Bait Uniprot Accession | P26010 | | Bait Uniprot Identifier | ITB7_HUMAN | | Bait Gene Name | ITGB7 | | Sequence Position | 772-779 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20741 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12606711 | | Comments | The NPxY motif (772-779) in human Integrin beta-7 (ITGB7) that mediates its interaction with the phosphotyrosine-binding (PTB) domain of mouse Docking protein 1 (Dok1) |
Record No : 27 |
| Instance ID | 10742 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | QDSNPLYK | | Bait Uniprot Accession | P26010 | | Bait Uniprot Identifier | ITB7_HUMAN | | Bait Gene Name | ITGB7 | | Sequence Position | 772-779 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20742 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12606711 | | Comments | The NPxY motif (772-779) in human Integrin beta-7 (ITGB7) that mediates its interaction with the phosphotyrosine-binding (PTB) domain of human Tensin-like C1 domain-containing phosphatase (TENC1) |
Record No : 28 |
| Instance ID | 10743 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | QDSNPLYK | | Bait Uniprot Accession | P26010 | | Bait Uniprot Identifier | ITB7_HUMAN | | Bait Gene Name | ITGB7 | | Sequence Position | 772-779 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20743 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12606711 | | Comments | The NPxY motif (772-779) in human Integrin beta-7 (ITGB7) that mediates its interaction with the phosphotyrosine-binding (PTB) domain of mouse Talin-1 (Tln1) |
Record No : 29 |
| Instance ID | 10746 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | TVVNPKYE | | Bait Uniprot Accession | P05556 | | Bait Uniprot Identifier | ITB1_HUMAN | | Bait Gene Name | ITGB1 | | Sequence Position | 789-796 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Co-IP; Alanine scanning; Pull down; Y2H | | Interaction ID | 20746 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11741908 | | Comments | Interaction between the phosphotyrosine-binding (PTB) domain of human ICAP1 alpha and the NPXY motif (789-796) of human Integrin beta-1 |
Record No : 30 |
| Instance ID | 10748 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | TANNPLYK | | Bait Uniprot Accession | P05106 | | Bait Uniprot Identifier | ITB3_HUMAN | | Bait Gene Name | ITGB3 | | Sequence Position | 767-774 | | Critical Residues | P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | X-ray crystallography; Mutation analysis; NMR | | Interaction ID | 20748 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12535520, 18156175 | | Comments | The NPxY motif (767-774) in human Integrin beta-1 (ITGB1) that mediates its interaction with the phosphotyrosine-binding (PTB) domain of chicken Talin-1 (TLN1) |
Record No : 31 |
| Instance ID | 10760 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | TANNPLY | | Bait Uniprot Accession | P05106 | | Bait Uniprot Identifier | ITB3_HUMAN | | Bait Gene Name | ITGB3 | | Sequence Position | 767-773 | | Critical Residues | P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | NMR; Alanine scanning; SPR | | Interaction ID | 20760 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18156175, 20739287, 12606711 | | Comments | The phosphotyrosine binding (PTB) domain of human Docking protein 1 (DOK1) binds to tyrosine-phosphorylated NPxY motif of human Integrin beta-3 (ITGB3) |
Record No : 32 |
| Instance ID | 10761 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | TANNPLY | | Bait Uniprot Accession | P05106 | | Bait Uniprot Identifier | ITB3_HUMAN | | Bait Gene Name | ITGB3 | | Sequence Position | 767-773 | | Critical Residues | P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | NMR; Alanine scanning; SPR | | Interaction ID | 20761 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18156175, 20739287, 12606711 | | Comments | The phosphotyrosine binding (PTB) domain of human SHC-transforming protein 1 (SHC1) binds to tyrosine-phosphorylated NPxY motif (767-773) of human Integrin beta-3 (ITGB3) |
Record No : 33 |
| Instance ID | 10763 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | EIINPNY | | Bait Uniprot Accession | Q92835 | | Bait Uniprot Identifier | SHIP1_HUMAN | | Bait Gene Name | INPP5D | | Sequence Position | 909-915 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Pull down; Co-IP | | Interaction ID | 20763 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9083021 | | Comments | The phosphotyrosine binding (PTB) domain of human SHC-transforming protein 1 (SHC1) binds to tyrosine-phosphorylated NPxY motif (909-915) of human SH2-containing inositol phosphatase (SHIP/INPP5D) |
Record No : 34 |
| Instance ID | 10764 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | IAGNPAY | | Bait Uniprot Accession | P24394 | | Bait Uniprot Identifier | IL4RA_HUMAN | | Bait Gene Name | IL4R | | Sequence Position | 491-497 | | Critical Residues | P1; P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Mutation analysis; ITC; NMR | | Interaction ID | 20764 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8599766 | | Comments | The PTB domain of human Insulin receptor substrate 1 (IRS1) can recognize and bind specifically to phosphotyrosine-containing NPxY motif of human Interleukin-4 receptor subunit alpha |
Record No : 35 |
| Instance ID | 10765 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | TFTNITY | | Bait Uniprot Accession | P05106 | | Bait Uniprot Identifier | ITB3_HUMAN | | Bait Gene Name | ITGB3 | | Sequence Position | 779-785 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | NMR; Mutation analysis | | Interaction ID | 20765 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20739287 | | Comments | The phosphotyrosine binding (PTB) domain of human SHC-transforming protein 1 (SHC1) binds to tyrosine-phosphorylated NPxY motif (779-785) of human Integrin beta-3 (ITGB3) |
Record No : 36 |
| Instance ID | 10767 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | CFTNQGY | | Bait Uniprot Accession | P14784 | | Bait Uniprot Identifier | IL2RB_HUMAN | | Bait Gene Name | IL2RB | | Sequence Position | 358-364 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Co-IP; Mutation analysis; Pull down | | Interaction ID | 20767 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8643566 | | Comments | The phosphotyrosine-binding (PTB) domain of human SHC-transforming protein 1 (SHC1) interacts with the tyrosine-phosphorylated NPxY motif of human Interleukin-2 receptor subunit beta (IL2RB) |
Record No : 37 |
| Instance ID | 10768 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | LLPNHSY | | Bait Uniprot Accession | P16144 | | Bait Uniprot Identifier | ITB4_HUMAN | | Bait Gene Name | ITGB4 | | Sequence Position | 1590-1596 | | Critical Residues | P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Co-IP; Mutation analysis; Pull down | | Interaction ID | 20768 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11044453 | | Comments | The phosphotyrosine-binding (PTB) domain of human SHC-transforming protein 1 (SHC1) interacts with the tyrosine-phosphorylated NPxY motif of human Integrin beta-4 (ITGB4) |
Record No : 38 |
| Instance ID | 10769 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | MFENPLY | | Bait Uniprot Accession | Q92835 | | Bait Uniprot Identifier | SHIP1_HUMAN | | Bait Gene Name | INPP5D | | Sequence Position | 1016-1022 | | Critical Residues | P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Co-IP; Pull down; Protein kinase assay; Mutation analysis | | Interaction ID | 20769 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9099679 | | Comments | The phosphotyrosine binding (PTB) domain of human SHC-transforming protein 1 (SHC1) binds to tyrosine-phosphorylated NPxY motif (1016-1022) of human SH2-containing inositol phosphatase (SHIP/INPP5D) |
Record No : 39 |
| Instance ID | 10770 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | ASSNPEY | | Bait Uniprot Accession | P06213 | | Bait Uniprot Identifier | INSR_HUMAN | | Bait Gene Name | INSR | | Sequence Position | 993-999 | | Critical Residues | P4; P5; P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Protein kinase assay; Y2H; Alanine scanning | | Interaction ID | 20770 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8626723 | | Comments | The phosphotyrosine-binding (PTB) domain of human SHC-transforming protein 1 (SHC1) interacts with the tyrosine-phosphorylated NPxY motif of human Insulin receptor (INSR) |
Record No : 40 |
| Instance ID | 10771 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | ASSNPEY | | Bait Uniprot Accession | P06213 | | Bait Uniprot Identifier | INSR_HUMAN | | Bait Gene Name | INSR | | Sequence Position | 993-999 | | Critical Residues | P4; P5; P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20771 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8626723 | | Comments | The phosphotyrosine-binding (PTB) domain of human Insulin receptor substrate 1 (IRS1) interacts with the tyrosine-phosphorylated NPxY motif of human Insulin receptor (INSR) |
Record No : 41 |
| Instance ID | 10787 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LVCGE | | Bait Uniprot Accession | P15092 | | Bait Uniprot Identifier | IFI4_MOUSE | | Bait Gene Name | Ifi204 | | Sequence Position | 423-427 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down(GST tag) | | Interaction ID | 20787 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10951565 | | Comments | The Rb-binding LxCxE motif in the mouse Interferon-inducible protein p204 (Ifi204) that mediates binding to the mouse retinoblastoma protein (Rb) |
Record No : 42 |
| Instance ID | 10803 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LVCFE | | Bait Uniprot Accession | Q9R002 | | Bait Uniprot Identifier | IFI2_MOUSE | | Bait Gene Name | Ifi202 | | Sequence Position | 416-420 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag); Mutation analysis | | Interaction ID | 20803 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7890747 | | Comments | The Rb-binding LxCxE motif in the murine Interferon-inducible protein p202 that mediates binding to the mouse retinoblastoma protein (Rb) |
Record No : 43 |
| Instance ID | 10815 | | Regular Expression | RGD | | Motif Instance | RGD | | Bait Uniprot Accession | P21815 | | Bait Uniprot Identifier | SIAL_HUMAN | | Bait Gene Name | IBSP | | Sequence Position | 286-288 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20815 | | Interacting Domain | N-terminal Integrin beta subunit | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 10785511 | | Comments | The Integrin binding RGD motif in Human Integrin-binding Bone sialoprotein (BSP) that mediates binding to the Human Integrin beta-3 (ITGB3) |
Record No : 44 |
| Instance ID | 10846 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGNYS | | Bait Uniprot Accession | P17181 | | Bait Uniprot Identifier | INAR1_HUMAN | | Bait Gene Name | IFNAR1 | | Sequence Position | 534-539 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Thr-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Radiolabel; Ubiquitinase assay; Protein kinase assay; Co-IP; Mutation analysis; Pull down | | Interaction ID | 20846 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15337770, 14532120 | | Comments | Ubiquitination, endocytosis, and lysosomal degradation of the IFNAR1 (interferon alpha receptor 1) subunit of the type I interferon (IFN) receptor is mediated by the SCF ubiquitin ligase complex through a phosphorylation-dependent interaction with F-box and WD repeats protein beta-TrCP2 (FBXW11) |
Record No : 45 |
| Instance ID | 10847 | | Regular Expression | (Y)xNx | | Motif Instance | YVNI | | Bait Uniprot Accession | P35570 | | Bait Uniprot Identifier | IRS1_RAT | | Bait Gene Name | Irs1 | | Sequence Position | 895-898 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Beta turn | | Experimental Method(s) | Pull down; Protein kinase assay | | Interaction ID | 20847 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7504175 | | Comments | Tyrosine-phosphorylated (Y895) rat Insulin receptor substrate 1 (Irs1) binds specifically to the Src homology 2 (SH2) domain of rat Growth factor receptor-bound protein 2 |
Record No : 46 |
| Instance ID | 10857 | | Regular Expression | (Y)[IV]x[VILP] | | Motif Instance | YIDL | | Bait Uniprot Accession | P35570 | | Bait Uniprot Identifier | IRS1_RAT | | Bait Gene Name | Irs1 | | Sequence Position | 1172-1175 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down(GST tag) | | Interaction ID | 20857 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11572799 | | Comments | Tyrosine-phosphorylated (Y1172) rat Insulin receptor substrate 1 (Irs1) binds to the SH2 domain of the rat tyrosine phosphatase Shp2/Ptpn11 |
Record No : 47 |
| Instance ID | 10867 | | Regular Expression | (Y)[VLTFIC]xx | | Motif Instance | YTHM | | Bait Uniprot Accession | P06213 | | Bait Uniprot Identifier | INSR_HUMAN | | Bait Gene Name | INSR | | Sequence Position | 1361-1364 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20867 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7983060 | | Comments | The phosphorylated YHTM motif in the COOH terminus of the human Insulin receptor (INSR) has the ability to bind to the human PI3-kinase subunit p85-alpha, thereby activating the enzyme and mediating the effect of insulin to activate PI 3-kinase |
Record No : 48 |
| Instance ID | 10874 | | Regular Expression | G(Y)[KQ]xF | | Motif Instance | GYKAF | | Bait Uniprot Accession | P24394 | | Bait Uniprot Identifier | IL4RA_HUMAN | | Bait Gene Name | IL4R | | Sequence Position | 602-606 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; EMSA | | Interaction ID | 20874 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9712048 | | Comments | Human Interleukin-4 receptor subunit alpha (IL4R) gene regulation domain contains a tyrosine-based sequence that are essential for the proper activation of Human STAT6 and can function as a mobile STAT6 activation cassette |
Record No : 49 |
| Instance ID | 11024 | | Regular Expression | xxPxExx[FYWHDE]x | | Motif Instance | QGPEESDEF | | Bait Uniprot Accession | P51617 | | Bait Uniprot Identifier | IRAK1_HUMAN | | Bait Gene Name | IRAK1 | | Sequence Position | 702-710 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Mutation analysis | | Interaction ID | 21024 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12140561 | | Comments | The C-terminal TRAF domain of human TNF receptor-associated factor 6 (TRAF6) interacts with human Interleukin-1 receptor-associated kinase 1 (IRAK1) through the TRAF6 binding site (702-710) of IRAK1 |
Record No : 50 |
| Instance ID | 11025 | | Regular Expression | xxPxExx[FYWHDE]x | | Motif Instance | NQPVESDES | | Bait Uniprot Accession | P51617 | | Bait Uniprot Identifier | IRAK1_HUMAN | | Bait Gene Name | IRAK1 | | Sequence Position | 583-591 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Mutation analysis | | Interaction ID | 21025 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12140561 | | Comments | The C-terminal TRAF domain of human TNF receptor-associated factor 6 (TRAF6) interacts with human Interleukin-1 receptor-associated kinase 1 (IRAK1) through the TRAF6 binding site (583-591) of IRAK1 |
Record No : 51 |
| Instance ID | 11026 | | Regular Expression | xxPxExx[FYWHDE]x | | Motif Instance | PSPQENSYV | | Bait Uniprot Accession | P51617 | | Bait Uniprot Identifier | IRAK1_HUMAN | | Bait Gene Name | IRAK1 | | Sequence Position | 540-548 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Mutation analysis | | Interaction ID | 21026 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12140561 | | Comments | The C-terminal TRAF domain of human TNF receptor-associated factor 6 (TRAF6) interacts with human Interleukin-1 receptor-associated kinase 1 (IRAK1) through the TRAF6 binding site (540-548) of IRAK1 |
Record No : 52 |
| Instance ID | 11122 | | Regular Expression | xxx([ST])Px | | Motif Instance | SGRSPR | | Bait Uniprot Accession | Q14653 | | Bait Uniprot Identifier | IRF3_HUMAN | | Bait Gene Name | IRF3 | | Sequence Position | 336-341 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Pull down; Western blot; Co-IP; Mutation analysis | | Interaction ID | 21122 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16699525 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 interacts with the phosphorylated Ser339-Pro340 motif of human Interferon regulatory factor 3 (IRF3) |
Record No : 53 |
| Instance ID | 11131 | | Regular Expression | xxx([ST])Px | | Motif Instance | YGSSPC | | Bait Uniprot Accession | P35568 | | Bait Uniprot Identifier | IRS1_HUMAN | | Bait Gene Name | IRS1 | | Sequence Position | 431-436 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Co-IP; Alanine scanning; Mutation analysis | | Interaction ID | 21131 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21454638 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphoserine 434-containing motif in human Insulin receptor substrate 1 (IRS1) through its WW domain and enhances insulin actions and adipogenesis |
Record No : 54 |
| Instance ID | 11494 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TLV | | Bait Uniprot Accession | Q7TSN7 | | Bait Uniprot Identifier | IGSF5_MOUSE | | Bait Gene Name | Igsf5 | | Sequence Position | 368-370 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Mutational analysis; Co-IP; Pull down(GST tag) | | Interaction ID | 21494 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12773569 | | Comments | PDZ-binding motif in JAM4 (Igsf5) which binds to PDZ1 and PDZ4 of MAGI-1 |
Record No : 55 |
| Instance ID | 11630 | | Regular Expression | SDA$ | | Motif Instance | SDA | | Bait Uniprot Accession | P11688 | | Bait Uniprot Identifier | ITA5_MOUSE | | Bait Gene Name | Itga5 | | Sequence Position | 1051-1053 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 21630 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11852236 | | Comments | C-terminal PDZ domain-binding motif in mouse Integrin alpha-5 that mediates its interaction with SEMCAP-1, the mouse homologue of TIP-2/GIPC |
Record No : 56 |
| Instance ID | 11631 | | Regular Expression | SDA$ | | Motif Instance | SDA | | Bait Uniprot Accession | Q61739 | | Bait Uniprot Identifier | ITA6_MOUSE | | Bait Gene Name | Itga6 (Isoform Alpha | | Sequence Position | 1071-1073 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21631 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11852236 | | Comments | C-terminal PDZ domain-binding motif in mouse Integrin alpha-6 (Isoform Alpha-6X1A) that mediates its interaction with SEMCAP-1, the mouse homologue of TIP-2/GIPC |
Record No : 57 |
| Instance ID | 11632 | | Regular Expression | SYS$ | | Motif Instance | SYS | | Bait Uniprot Accession | Q61739 | | Bait Uniprot Identifier | ITA6_MOUSE | | Bait Gene Name | Itga6 (Isoform Alpha | | Sequence Position | 1088-1091 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 21632 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11852236 | | Comments | C-terminal PDZ domain-binding motif in mouse Integrin alpha-6 (Isoform Alpha-6X1B) that mediates its interaction with SEMCAP-1, the mouse homologue of TIP-2/GIPC |
Record No : 58 |
| Instance ID | 11640 | | Regular Expression | L[EQ]E[FL]LG[DE] | | Motif Instance | LDELLGN | | Bait Uniprot Accession | Q14653 | | Bait Uniprot Identifier | IRF3_HUMAN | | Bait Gene Name | IRF3 | | Sequence Position | 140-146 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21640 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9649509 | | Comments | Consensus E6-binding sequence in human Interferon regulatory factor 3 for binding to E6 oncoprotein of Human papillomavirus type 16 |
Record No : 59 |
| Instance ID | 11678 | | Regular Expression | KVGFFKR | | Motif Instance | KVGFFKR | | Bait Uniprot Accession | P08514 | | Bait Uniprot Identifier | ITA2B_HUMAN | | Bait Gene Name | ITGA2B | | Sequence Position | 1020-1026 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide-affinity chromatography; Dot-blots | | Interaction ID | 21678 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20034469, 9030514 | | Comments | The highly conserved motif in the cytoplasmic tail of Integrin alpha-IIb which acts as a recognition site for the binding of Calcium and integrin-binding protein 1 |
Record No : 60 |
| Instance ID | 11679 | | Regular Expression | KVGFFKR | | Motif Instance | KVGFFKR | | Bait Uniprot Accession | P08514 | | Bait Uniprot Identifier | ITA2B_HUMAN | | Bait Gene Name | ITGA2B | | Sequence Position | 1020-1026 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Peptide-affinity chromatography; Dot-blots | | Interaction ID | 21679 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20034469, 15205468 | | Comments | The highly conserved motif in the cytoplasmic tail of Integrin alpha-IIb which acts as a recognition site for the binding of the catalytic subunit of protein phosphatase 1 (PPP1CA) |
Record No : 61 |
| Instance ID | 11680 | | Regular Expression | KVGFFKR | | Motif Instance | KVGFFKR | | Bait Uniprot Accession | P08514 | | Bait Uniprot Identifier | ITA2B_HUMAN | | Bait Gene Name | ITGA2B | | Sequence Position | 1020-1026 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide Screening of High Density Protein Arrays; Dot-blot assay | | Interaction ID | 21680 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20034469, 15075326 | | Comments | The highly conserved motif in the cytoplasmic tail of Integrin alpha-IIb which acts as a recognition site for the binding of Chloride conductance regulatory protein ICln |
Record No : 62 |
| Instance ID | 11681 | | Regular Expression | KVGFFKR | | Motif Instance | KVGFFKR | | Bait Uniprot Accession | P08514 | | Bait Uniprot Identifier | ITA2B_HUMAN | | Bait Gene Name | ITGA2B | | Sequence Position | 1020-1026 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide-affinity chromatography; Dot-blots | | Interaction ID | 21681 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20034469 | | Comments | The highly conserved motif in the cytoplasmic tail of Integrin alpha-IIb which acts as a recognition site for the binding of E3 ubiquitin-protein ligase RNF181 |
Record No : 63 |
| Instance ID | 11879 | | Regular Expression | GFFKR | | Motif Instance | GFFKR | | Bait Uniprot Accession | P26006 | | Bait Uniprot Identifier | ITA3_HUMAN | | Bait Gene Name | ITGA3 | | Sequence Position | 1017-1021 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21879 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1911778 | | Comments | The conserved membrane proximal binding site of the cytoplasmic domain of human Integrin alpha-3 subunit that interacts with human Calreticulin |
Record No : 64 |
| Instance ID | 11880 | | Regular Expression | GFFKR | | Motif Instance | GFFKR | | Bait Uniprot Accession | P26006 | | Bait Uniprot Identifier | ITA3_HUMAN | | Bait Gene Name | ITGA3 | | Sequence Position | 1017-1021 | | Critical Residues | P2; P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Y2H | | Interaction ID | 21880 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10094488 | | Comments | The conserved membrane proximal binding site of the cytoplasmic domain of human Integrin alpha-3 subunit that interacts with human Guanine nucleotide exchange factor MSS4 |
Record No : 65 |
| Instance ID | 11881 | | Regular Expression | GFFKR | | Motif Instance | GFFKR | | Bait Uniprot Accession | P26006 | | Bait Uniprot Identifier | ITA3_HUMAN | | Bait Gene Name | ITGA3 | | Sequence Position | 1017-1021 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Y2H | | Interaction ID | 21881 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10094488 | | Comments | The conserved membrane proximal binding site of the cytoplasmic domain of human Integrin alpha-3 subunit that interacts with human Bridging integrator protein-1 (BIN1) |
Record No : 66 |
| Instance ID | 11882 | | Regular Expression | YxxM | | Motif Instance | YICM | | Bait Uniprot Accession | P35570 | | Bait Uniprot Identifier | IRS1_RAT | | Bait Gene Name | Irs1 | | Sequence Position | 460-463 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21882 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif 1 (460-463) in rat Insulin receptor substrate 1 that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 67 |
| Instance ID | 11883 | | Regular Expression | YxxM | | Motif Instance | YTEM | | Bait Uniprot Accession | P35570 | | Bait Uniprot Identifier | IRS1_RAT | | Bait Gene Name | Irs1 | | Sequence Position | 546-549 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21883 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif 2 (546-549) in rat Insulin receptor substrate 1 that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 68 |
| Instance ID | 11884 | | Regular Expression | YxxM | | Motif Instance | YMPM | | Bait Uniprot Accession | P35570 | | Bait Uniprot Identifier | IRS1_RAT | | Bait Gene Name | Irs1 | | Sequence Position | 608-611 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21884 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif 3 (608-611) in rat Insulin receptor substrate 1 that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 69 |
| Instance ID | 11885 | | Regular Expression | YxxM | | Motif Instance | YMPM | | Bait Uniprot Accession | P35570 | | Bait Uniprot Identifier | IRS1_RAT | | Bait Gene Name | Irs1 | | Sequence Position | 628-631 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21885 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif 4 (628-631) in rat Insulin receptor substrate 1 that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 70 |
| Instance ID | 11886 | | Regular Expression | YxxM | | Motif Instance | YMMM | | Bait Uniprot Accession | P35570 | | Bait Uniprot Identifier | IRS1_RAT | | Bait Gene Name | Irs1 | | Sequence Position | 658-661 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21886 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif 5 (658-661) in rat Insulin receptor substrate 1 that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 71 |
| Instance ID | 11887 | | Regular Expression | YxxM | | Motif Instance | YMNM | | Bait Uniprot Accession | P35570 | | Bait Uniprot Identifier | IRS1_RAT | | Bait Gene Name | Irs1 | | Sequence Position | 727-730 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21887 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif 6 (727-730) in rat Insulin receptor substrate 1 that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 72 |
| Instance ID | 11888 | | Regular Expression | YxxM | | Motif Instance | YMNM | | Bait Uniprot Accession | P35570 | | Bait Uniprot Identifier | IRS1_RAT | | Bait Gene Name | Irs1 | | Sequence Position | 939-942 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21888 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif 7 (939-942) in rat Insulin receptor substrate 1 that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 73 |
| Instance ID | 11933 | | Regular Expression | NPxY | | Motif Instance | NPAY | | Bait Uniprot Accession | P24394 | | Bait Uniprot Identifier | IL4RA_HUMAN | | Bait Gene Name | IL4R | | Sequence Position | 494-497 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR | | Interaction ID | 21933 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8599766, 7537849 | | Comments | The tyrosine-phosphorylated NPXY motif of Interleukin-4 receptor subunit alpha that mediates its interaction with the PTB domain of Insulin receptor substrate 1 (IRS-1) |
Record No : 74 |
| Instance ID | 11934 | | Regular Expression | NPxY | | Motif Instance | NPEY | | Bait Uniprot Accession | P08069 | | Bait Uniprot Identifier | IGF1R_HUMAN | | Bait Gene Name | IGF1R | | Sequence Position | 977-980 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21934 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7541045, 7537849 | | Comments | The tyrosine-phosphorylated NPXY motif of Insulin-like growth factor 1 receptor (IGF1R) that mediates its interaction with the PTB domain of Insulin receptor substrate 1 (IRS-1) |
Record No : 75 |
| Instance ID | 11935 | | Regular Expression | NPxY | | Motif Instance | NPEY | | Bait Uniprot Accession | P06213 | | Bait Uniprot Identifier | INSR_HUMAN | | Bait Gene Name | INSR | | Sequence Position | 996-999 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Y2H | | Interaction ID | 21935 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7537849, 7935368 | | Comments | The tyrosine-phosphorylated NPXY motif of Insulin receptor that mediates its interaction with the PTB domain of Insulin receptor substrate 1 (IRS-1) |
Record No : 76 |
| Instance ID | 11936 | | Regular Expression | NPxY | | Motif Instance | NPEY | | Bait Uniprot Accession | P06213 | | Bait Uniprot Identifier | INSR_HUMAN | | Bait Gene Name | INSR | | Sequence Position | 996-999 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Y2H | | Interaction ID | 21936 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7537849 | | Comments | The tyrosine-phosphorylated NPXY motif of Insulin receptor that mediates its interaction with the PTB domain of SHC-transforming protein 1 |
Record No : 77 |
| Instance ID | 11938 | | Regular Expression | NPxY | | Motif Instance | NPEY | | Bait Uniprot Accession | P08069 | | Bait Uniprot Identifier | IGF1R_HUMAN | | Bait Gene Name | IGF1R | | Sequence Position | 977-980 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21938 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7541045, 7537849 | | Comments | The tyrosine-phosphorylated NPXY motif of Insulin-like growth factor 1 receptor (IGF1R) that mediates its interaction with the PTB domain of SHC-transforming protein 1 |
Record No : 78 |
| Instance ID | 11942 | | Regular Expression | Y[VI]N | | Motif Instance | YVN | | Bait Uniprot Accession | P35568 | | Bait Uniprot Identifier | IRS1_HUMAN | | Bait Gene Name | IRS1 | | Sequence Position | 896-898 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21942 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8491186 | | Comments | The short sequence motif present in Insulin receptor substrate 1 that specifically binds the SH2 domain of Growth factor receptor-bound protein 2 with high affinity |
Record No : 79 |
| Instance ID | 12047 | | Regular Expression | FxxxVQxLTG | | Motif Instance | FRSIVQQLTG | | Bait Uniprot Accession | O82170 | | Bait Uniprot Identifier | O82170_ARATH | | Bait Gene Name | IKU1 | | Sequence Position | 55-64 | | Critical Residues | P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 22047 | | Interacting Domain | WRKY domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22535423, 20545893 | | Comments | The VQ-motif in IKU1 of Arabidopsis thaliana that interacts with the WRKY domain of Arabidopsis WRKY transcription factor 10 (WRKY10) and regulates endosperm growth and seed size in Arabidopsis |
Record No : 80 |
| Instance ID | 12055 | | Regular Expression | [ILFV][ILFV]xxx[DE][DE]xx[DE] | | Motif Instance | LLSTSEEQIE | | Bait Uniprot Accession | P17181 | | Bait Uniprot Identifier | INAR1_HUMAN | | Bait Gene Name | IFNAR1 | | Sequence Position | 491-500 | | Critical Residues | P1; P2; P7; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Coil | | Experimental Method(s) | X-ray crystallography; Site-directed mutagenesis; Pull down(GST tag) | | Interaction ID | 22055 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24704786 | | Comments | The peptide motif within the intracellular domain of human Interferon alpha receptor chain 1 (IFNAR1) that is necessary for its interaction with human Tyrosine kinase 2 (TYK2) as well as for TYK2 signaling |
Record No : 81 |
| Instance ID | 12071 | | Regular Expression | NPx[FY] | | Motif Instance | NPKY | | Bait Uniprot Accession | P09055 | | Bait Uniprot Identifier | ITB1_MOUSE | | Bait Gene Name | Itgb1 | | Sequence Position | 792-795 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22071 | | Interacting Domain | FERM domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22561348 | | Comments | The FERM domain of mouse Sorting nexin-17 (Snx17) binds to the NPX(Y/F) motif in the cytoplasmic domain of mouse Integrin beta-1 (Itgb1) to stabilize beta-1 integrins, resulting in their recycling to the cell surface where they can be reused |
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