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Total : 8 Records
Record No : 1 |
| Instance ID | 10241 | | Regular Expression | [DE][DE]xxxVP[DE] | | Motif Instance | EEPQTVPE | | Bait Uniprot Accession | P05412 | | Bait Uniprot Identifier | JUN_HUMAN | | Bait Gene Name | JUN | | Sequence Position | 227-234 | | Critical Residues | P6; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 20241 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12615916 | | Comments | A consensus motif in human Transcription factor AP-1 (JUN) whose integrity is essential for the interaction with human E3 ubiquitin-protein ligase RFWD2 (or human COP1) causing suppression of AP-1-dependent transcription |
Record No : 2 |
| Instance ID | 10244 | | Regular Expression | [DE][DE]xxxVP[DE] | | Motif Instance | DEPQTVPD | | Bait Uniprot Accession | P17535 | | Bait Uniprot Identifier | JUND_HUMAN | | Bait Gene Name | JUND | | Sequence Position | 241-248 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20244 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12615916 | | Comments | A consensus motif in human Transcription factor jun-D whose integrity is essential for the interaction with human E3 ubiquitin-protein ligase RFWD2 (or human COP1) |
Record No : 3 |
| Instance ID | 10528 | | Regular Expression | [KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF] | | Motif Instance | KILKQSMTLNL | | Bait Uniprot Accession | P05412 | | Bait Uniprot Identifier | JUN_HUMAN | | Bait Gene Name | JUN | | Sequence Position | 32-42 | | Critical Residues | P9; P11 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20528 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9925641, 8945519 | | Comments | MAPK docking motif in human Transcription factor AP-1 (or Proto-oncogene c-Jun) that mediates binding to human Stress-activated protein kinase JNK2 (or MAP kinase 9) |
Record No : 4 |
| Instance ID | 10824 | | Regular Expression | [LIVMP]x{0,2}(T)Pxx([ST]) | | Motif Instance | PGETPPLS | | Bait Uniprot Accession | P05412 | | Bait Uniprot Identifier | JUN_HUMAN | | Bait Gene Name | JUN | | Sequence Position | 236-243 | | Critical Residues | P8 | | Motif PTM(s) | Phosphorylation at Ser-P8 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding to perpetrator; Mutation disrupting interaction; Competition binding | | Interaction ID | 20824 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16023596 | | Comments | Phosphorylation of Human c-Jun by GSK3 at Ser-243 creates a high-affinity binding site for the E3 ligase FBW7, which targets c-Jun for polyubiquitination and proteasomal degradation |
Record No : 5 |
| Instance ID | 11068 | | Regular Expression | PPxY | | Motif Instance | PPVY | | Bait Uniprot Accession | P05627 | | Bait Uniprot Identifier | JUN_MOUSE | | Bait Gene Name | Jun | | Sequence Position | 167-170 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Ubiquitinase assay; Co-IP; Colocalization; Mutation analysis | | Interaction ID | 21068 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16901904, 15469925, 11828324 | | Comments | The PPXY motif of mouse Proto-oncogene c-Jun that binds to the WW domain of mouse E3 ubiquitin-protein ligase Itch which targets Jun for lysosomal degradation |
Record No : 6 |
| Instance ID | 11069 | | Regular Expression | PPxY | | Motif Instance | PPVY | | Bait Uniprot Accession | P09450 | | Bait Uniprot Identifier | JUNB_MOUSE | | Bait Gene Name | Junb | | Sequence Position | 176-179 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Ubiquitinase assay; Co-IP; Pull down; Mutation analysis | | Interaction ID | 21069 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11828324 | | Comments | The PPXY motif of mouse Transcription factor Jun-b that binds to the WW domain of mouse E3 ubiquitin-protein ligase Itch and induces ubiquitination of Jun-b |
Record No : 7 |
| Instance ID | 11083 | | Regular Expression | xxx([ST])Px | | Motif Instance | LLTSPD | | Bait Uniprot Accession | P05412 | | Bait Uniprot Identifier | JUN_HUMAN | | Bait Gene Name | JUN | | Sequence Position | 60-65 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Alanine scanning; EMSA | | Interaction ID | 21083 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11432833 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser63-Pro motif of human Proto-oncogene c-Jun |
Record No : 8 |
| Instance ID | 11092 | | Regular Expression | xxx([ST])Px | | Motif Instance | KLASPE | | Bait Uniprot Accession | P05412 | | Bait Uniprot Identifier | JUN_HUMAN | | Bait Gene Name | JUN | | Sequence Position | 70-75 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Alanine scanning; EMSA | | Interaction ID | 21092 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11432833 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser73-Pro motif of human Proto-oncogene c-Jun |
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