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Total : 38 Records
Record No : 1 |
| Instance ID | 10270 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | PLDLT | | Bait Uniprot Accession | Q96JN0 | | Bait Uniprot Identifier | LCOR_HUMAN | | Bait Gene Name | LCOR | | Sequence Position | 64-68 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20270 | | Interacting Domain | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12535528 | | Comments | Ligand-dependent nuclear receptor corepressor LCoR interacts with the transcriptional corepressor CtBP via the PxDLS motif |
Record No : 2 |
| Instance ID | 10535 | | Regular Expression | FxFP | | Motif Instance | FKFP | | Bait Uniprot Accession | G5EDL0 | | Bait Uniprot Identifier | G5EDL0_CAEEL | | Bait Gene Name | lin-1 | | Sequence Position | 420-423 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Protein kinase assay | | Interaction ID | 20535 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9691039 | | Comments | The FXFP motif in the Caenorhabditis elegans transcription factor LIN-1 that mediates binding to mouse MAP kinase 1 (or ERK-2) |
Record No : 3 |
| Instance ID | 10591 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | TGLNPNAKVWQEI | | Bait Uniprot Accession | Q71RC2 | | Bait Uniprot Identifier | LARP4_HUMAN | | Bait Gene Name | LARP4 | | Sequence Position | 13-25 | | Critical Residues | P3; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Mutation analysis; ITC; X-ray crystallography | | Interaction ID | 20591 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21098120 | | Comments | The PABP-interacting motif 2 (PAM2) in human La-related protein 4 (LARP4) that mediates binding to the MLLE domain of Polyadenylate-binding protein 1 (PABP1/PABPC1/PABPC2) |
Record No : 4 |
| Instance ID | 10592 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | SELNPNAEVWGAP | | Bait Uniprot Accession | Q92615 | | Bait Uniprot Identifier | LAR4B_HUMAN | | Bait Gene Name | LARP4B | | Sequence Position | 54-66 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag) | | Interaction ID | 20592 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20573744 | | Comments | The PABP-interacting motif 2 (PAM2) in human La-related protein 4B (LARP4B) that mediates binding to the MLLE domain of Polyadenylate-binding protein 1 (PABP1/PABPC1/PABPC2) |
Record No : 5 |
| Instance ID | 10614 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | MQRSIMSFFHP | | Bait Uniprot Accession | P18858 | | Bait Uniprot Identifier | DNLI1_HUMAN | | Bait Gene Name | LIG1 | | Sequence Position | 1-11 | | Critical Residues | P8; P9 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; Co-IP; Pull down(GST tag) | | Interaction ID | 20614 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9649448 | | Comments | The PCNA binding PIP box motif in human DNA ligase 1 (LIG1) that mediates interaction with human Proliferating cell nuclear antigen (PCNA/Cyclin) |
Record No : 6 |
| Instance ID | 10659 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | RKRTYL | | Bait Uniprot Accession | P36762 | | Bait Uniprot Identifier | VL2_HPV49 | | Bait Gene Name | L2 | | Sequence Position | 516-521 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Display technology | | Interaction ID | 20659 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18828675 | | Comments | C-terminal class 1 PDZ-binding motif in the Minor capsid protein L2 of Human papillomavirus that binds to the human Scribble (SCRIB) PDZ domain |
Record No : 7 |
| Instance ID | 10720 | | Regular Expression | xP[TS]APx | | Motif Instance | TPTAPQ | | Bait Uniprot Accession | Q6UWE0 | | Bait Uniprot Identifier | LRSM1_HUMAN | | Bait Gene Name | LRSAM1 | | Sequence Position | 648-653 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20720 | | Interacting Domain | UEV domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15256501 | | Comments | Bivalent binding of the UEV domain of human Tumor susceptibility gene 101 protein (TSG101) to the PTAP motif (648-653) of human TAL (TSG101-associated ligase), also known as E3 ubiquitin-protein ligase LRSAM1, is essential for TAL-mediated ubiquitylation of TSG101 |
Record No : 8 |
| Instance ID | 10721 | | Regular Expression | xP[TS]APx | | Motif Instance | RPSAPP | | Bait Uniprot Accession | Q6UWE0 | | Bait Uniprot Identifier | LRSM1_HUMAN | | Bait Gene Name | LRSAM1 | | Sequence Position | 660-665 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20721 | | Interacting Domain | UEV domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15256501 | | Comments | Bivalent binding of the UEV domain of human Tumor susceptibility gene 101 protein (TSG101) to the PTAP motif (660-665) of human TAL (TSG101-associated ligase), also known as E3 ubiquitin-protein ligase LRSAM1, is essential for TAL-mediated ubiquitylation of TSG101 |
Record No : 9 |
| Instance ID | 10747 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | NFDNPVYR | | Bait Uniprot Accession | Q14114 | | Bait Uniprot Identifier | LRP8_HUMAN | | Bait Gene Name | LRP8 | | Sequence Position | 860-867 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; Pull down; X-ray crystallography | | Interaction ID | 20747 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12737822 | | Comments | Interaction between the phosphotyrosine binding (PTB) domain of the Mouse adaptor protein Disabled-1 (Dab1) and the NPXY motif of human Reelin, the very low-density lipoprotein receptor, the Apolipoprotein E receptor 2 (APOER2/LRP8) |
Record No : 10 |
| Instance ID | 10749 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | EIGNPTYK | | Bait Uniprot Accession | Q07954 | | Bait Uniprot Identifier | LRP1_HUMAN | | Bait Gene Name | LRP1 | | Sequence Position | 4467-4474 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Mutation analysis; Knock out | | Interaction ID | 20749 | | Interacting Domain | PTB domain | | Disease Association(s) | Alzheimer's disease | | Inhibitor(s) | Unknown | | Reference(s) | 15115822, 16382151 | | Comments | The interaction of the phosphotyrosine-binding (PTB) domain of the human adaptor protein FE65/APBB1 with the NPxY motif (4467-4474) of human Apolipoprotein E receptor LRP1 whereby FE65 acts as a functional linker between APP and LRP |
Record No : 11 |
| Instance ID | 10751 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | NFTNPVYA | | Bait Uniprot Accession | Q07954 | | Bait Uniprot Identifier | LRP1_HUMAN | | Bait Gene Name | LRP1 | | Sequence Position | 4501-4508 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Mutation analysis | | Interaction ID | 20751 | | Interacting Domain | PTB domain | | Disease Association(s) | Alzheimer's disease | | Inhibitor(s) | Unknown | | Reference(s) | 15115822 | | Comments | The interaction of the phosphotyrosine-binding (PTB) domain of the human adaptor protein FE65/APBB1 with the NPxY motif (4501-4508) of human Apolipoprotein E receptor LRP1 whereby FE65 acts as a functional linker between APP and LRP |
Record No : 12 |
| Instance ID | 10752 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | NFDNPVYQ | | Bait Uniprot Accession | P01130 | | Bait Uniprot Identifier | LDLR_HUMAN | | Bait Gene Name | LDLR | | Sequence Position | 822-829 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Y2H | | Interaction ID | 20752 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9837937 | | Comments | Interaction between the phosphotyrosine binding (PTB) domain of the Mouse adaptor protein Disabled-1 (Dab1) and the NPXY motif of human Low-density lipoprotein receptor (LDLR) |
Record No : 13 |
| Instance ID | 10754 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | GLDNPAYV | | Bait Uniprot Accession | Q8TBB1 | | Bait Uniprot Identifier | LNX1_HUMAN | | Bait Gene Name | LNX1 | | Sequence Position | 178-185 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence polarization spectroscopy; Co-IP; Pull down; Y2H; Competition binding | | Interaction ID | 20754 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9846878, 9535908 | | Comments | High-affinity binding of the Drosophila Numb phosphotyrosine-binding (PTB) domain to the NPXY motif of human E3 ubiquitin-protein ligase LNX1 |
Record No : 14 |
| Instance ID | 10842 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGHES | | Bait Uniprot Accession | P03230 | | Bait Uniprot Identifier | LMP1_EBVB9 | | Bait Gene Name | LMP1 | | Sequence Position | 210-215 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20842 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Epstein-Barr Virus (EBV) infection | | Inhibitor(s) | Unknown | | Reference(s) | 14523018 | | Comments | The Epstein-Barr virus latent membrane protein 1 (LMP1) is a pseudo-substrate of the SCF-betaTrCP ubiquitin ligase complex and the interaction between LMP1 and the F-box protein beta-TrCP (BTRC) restricts the extent of LMP1-induced NF-kappaB signaling |
Record No : 15 |
| Instance ID | 10852 | | Regular Expression | (Y)xNx | | Motif Instance | YVNV | | Bait Uniprot Accession | O54957 | | Bait Uniprot Identifier | LAT_MOUSE | | Bait Gene Name | Lat | | Sequence Position | 175-178 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20852 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10811803 | | Comments | Tyrosine-phosphorylated (Y175) mouse 36 kDa phospho-tyrosine adapter protein Lat binds to the SH2 domain of mouse Grb2 adaptor protein |
Record No : 16 |
| Instance ID | 10853 | | Regular Expression | (Y)xNx | | Motif Instance | YVNV | | Bait Uniprot Accession | O54957 | | Bait Uniprot Identifier | LAT_MOUSE | | Bait Gene Name | Lat | | Sequence Position | 195-198 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20853 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10811803 | | Comments | Tyrosine-phosphorylated (Y195) mouse 36 kDa phospho-tyrosine adapter protein Lat binds to the SH2 domain of mouse Grb2 adaptor protein |
Record No : 17 |
| Instance ID | 10854 | | Regular Expression | (Y)xNx | | Motif Instance | YENL | | Bait Uniprot Accession | O54957 | | Bait Uniprot Identifier | LAT_MOUSE | | Bait Gene Name | Lat | | Sequence Position | 235-238 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20854 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10811803 | | Comments | Tyrosine-phosphorylated (Y235) mouse 36 kDa phospho-tyrosine adapter protein Lat binds to the SH2 domain of mouse Grb2 adaptor protein |
Record No : 18 |
| Instance ID | 10860 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YEPP | | Bait Uniprot Accession | Q60787 | | Bait Uniprot Identifier | LCP2_MOUSE | | Bait Gene Name | Lcp2 | | Sequence Position | 145-148 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Extended conformation | | Experimental Method(s) | NMR | | Interaction ID | 20860 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16436281 | | Comments | The Src homology 2 (SH2) domain of mouse interleukin-2 tyrosine kinase (Itk) binds to a phosphotyrosine-containing peptide (pY) from mouse Lymphocyte cytosolic protein 2 (Lcp2/Slp-76), a phospholigand binding partner of Itk in T cells |
Record No : 19 |
| Instance ID | 10870 | | Regular Expression | (Y)[VLTFIC]xx | | Motif Instance | YLVV | | Bait Uniprot Accession | O43561 | | Bait Uniprot Identifier | LAT_HUMAN | | Bait Gene Name | LAT | | Sequence Position | 132-135 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Far Western blotting; Pull down; Mutation analysis | | Interaction ID | 20870 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10811803, 11368773 | | Comments | Upon tyrosine phosphorylation (Y132), the integral membrane adaptor protein, human Linker for activation of T-cells (LAT), binds directly to the SH2-domain of the human Phospholipase C-gamma-1 (PLCG1) causing PLC-gamma activation which, in turn, regulates Ras activation |
Record No : 20 |
| Instance ID | 10899 | | Regular Expression | xxx[PV]xxP | | Motif Instance | TPAPALP | | Bait Uniprot Accession | Q12446 | | Bait Uniprot Identifier | LAS17_YEAST | | Bait Gene Name | LAS17 | | Sequence Position | 216-222 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Pull down(GST tag) | | Interaction ID | 20899 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10648568 | | Comments | The COOH-terminal tail of yeast Myosin-3 contains an SH3 domain that interacts with yeast Bee1p (Las17p) |
Record No : 21 |
| Instance ID | 10900 | | Regular Expression | xxx[PV]xxP | | Motif Instance | TPAPALP | | Bait Uniprot Accession | Q12446 | | Bait Uniprot Identifier | LAS17_YEAST | | Bait Gene Name | LAS17 | | Sequence Position | 216-222 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Pull down(GST tag) | | Interaction ID | 20900 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10648568 | | Comments | The COOH-terminal tail of yeast Myosin-5 contains an SH3 domain that interacts with yeast Bee1p (Las17p) |
Record No : 22 |
| Instance ID | 11003 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | YRQSPDGA | | Bait Uniprot Accession | Q9UIQ6 | | Bait Uniprot Identifier | LCAP_HUMAN | | Bait Gene Name | LNPEP | | Sequence Position | 95-102 | | Critical Residues | P2; P5; P6; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag); Alanine scanning; X-ray crystallography | | Interaction ID | 21003 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12080061, 22153077 | | Comments | The N-terminal region of ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif in human Leucyl-cystinyl aminopeptidase (LNPEP) |
Record No : 23 |
| Instance ID | 11020 | | Regular Expression | [PSAT]x[QE]E | | Motif Instance | PHQE | | Bait Uniprot Accession | P36941 | | Bait Uniprot Identifier | TNR3_HUMAN | | Bait Gene Name | LTBR | | Sequence Position | 402-405 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 21020 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14517219 | | Comments | "Structurally adaptive ""hot spots"" in the binding crevice on the surface of human TNF receptor-associated factor 3 (TRAF3) promote molecular interactions with human Lymphotoxin-beta receptor (LTBR)" |
Record No : 24 |
| Instance ID | 11023 | | Regular Expression | PxQxxD | | Motif Instance | PQQATD | | Bait Uniprot Accession | P03230 | | Bait Uniprot Identifier | LMP1_EBVB9 | | Bait Gene Name | LMP1 | | Sequence Position | 204-209 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Mutation analysis | | Interaction ID | 21023 | | Interacting Domain | MATH domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 10518213 | | Comments | TRAF2-binding consensus motif in the Epstein-Barr virus (EBV) oncoprotein Latent membrane protein 1 (LMP1) that binds to human TNF receptor-associated factor 2 (TRAF2) |
Record No : 25 |
| Instance ID | 11052 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | P13285 | | Bait Uniprot Identifier | LMP2_EBVB9 | | Bait Gene Name | LMP2 | | Sequence Position | 57-60 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | ITC; NMR | | Interaction ID | 21052 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17437719 | | Comments | The PY motif of Epstein-Barr virus Latent membrane protein 2 (LMP2) binds to the WW domain of mouse E3 ubiquitin-protein ligase Itch |
Record No : 26 |
| Instance ID | 11053 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | P13285 | | Bait Uniprot Identifier | LMP2_EBVB9 | | Bait Gene Name | LMP2 | | Sequence Position | 98-101 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 21053 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11046148 | | Comments | The PY motif of Epstein-Barr virus Latent membrane protein 2 (LMP2) binds to the WW domain of human E3 ubiquitin-protein ligase ITCH/AIP4 and may thereby regulate B-cell receptor (BCR) signaling |
Record No : 27 |
| Instance ID | 11242 | | Regular Expression | xGxxPG | | Motif Instance | LGTIPG | | Bait Uniprot Accession | P07942 | | Bait Uniprot Identifier | LAMB1_HUMAN | | Bait Gene Name | LAMB1 | | Sequence Position | 463-468 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Type VIII reverse beta-turn | | Experimental Method(s) | Gelatin zymography; ELISA | | Interaction ID | 21242 | | Interacting Domain | Elastin-binding domain of EBP | | Disease Association(s) | Unknown | | Inhibitor(s) | Galactosugars | | Reference(s) | 15148686, 1848864, 2550450, 11723829 | | Comments | The 67-kD human elastin-binding protein (EBP) binds to a hexapeptide motif from human Laminin subunit beta-1 (LAMB1) |
Record No : 28 |
| Instance ID | 11496 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | SDV | | Bait Uniprot Accession | A2ARV4 | | Bait Uniprot Identifier | LRP2_MOUSE | | Bait Gene Name | Lrp2 | | Sequence Position | 4658-4660 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21496 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11274227 | | Comments | Class I PDZ binding motif at the C-terminus of Megalin (Lrp2) that mediates its interaction with the fifth PDZ domain of Magi1 |
Record No : 29 |
| Instance ID | 11497 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | SDV | | Bait Uniprot Accession | A2ARV4 | | Bait Uniprot Identifier | LRP2_MOUSE | | Bait Gene Name | Lrp2 | | Sequence Position | 4658-4660 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21497 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11274227 | | Comments | Class I PDZ binding motif at the C-terminus of Megalin (Lrp2) that mediates its interaction with the fifth PDZ domain in Magi2 |
Record No : 30 |
| Instance ID | 11797 | | Regular Expression | [DE][LI]xCxE | | Motif Instance | DLFCSE | | Bait Uniprot Accession | Q2I7F9 | | Bait Uniprot Identifier | Q2I7F9_SV40 | | Bait Gene Name | large T | | Sequence Position | 101-106 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; Competition binding assay | | Interaction ID | 21797 | | Interacting Domain | B-box portion of the Rb pocket domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 2138977, 2198278, 11226179 | | Comments | The LxCxE motif of SV40 large T antigen that binds to the B-box portion of the pocket domain of the human retinoblastoma suppressor protein (pRb) and is required for inactivation of pRb that leads to tumorigenesis induced by SV40 |
Record No : 31 |
| Instance ID | 11851 | | Regular Expression | FGPxL | | Motif Instance | FGPAL | | Bait Uniprot Accession | Q9Y250 | | Bait Uniprot Identifier | LZTS1_HUMAN | | Bait Gene Name | LZTS1 | | Sequence Position | 373-377 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Phage Display; SPOT Analysis | | Interaction ID | 21851 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15845542 | | Comments | The consensus motif in human FEZ1 that represent putative target sites for binding of Cyclophilin A, a peptidyl-prolyl cis/trans-isomerase that is involved in multiple signaling events of eukaryotic cells |
Record No : 32 |
| Instance ID | 11957 | | Regular Expression | PxLPx[IL] | | Motif Instance | PTLPKL | | Bait Uniprot Accession | P98164 | | Bait Uniprot Identifier | LRP2_HUMAN | | Bait Gene Name | LRP2 | | Sequence Position | 4458-4463 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; Y2H; Pull down(GST tag) | | Interaction ID | 21957 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22649097, 11095640 | | Comments | The PxLPxI/L motif (4458-4463) of human Low-density lipoprotein receptor-related protein 2 (Megalin) recognized by Ankyrin repeat family A protein 2 (ANKRA2) for binding to the ankyrin repeat domain |
Record No : 33 |
| Instance ID | 11958 | | Regular Expression | PxLPx[IL] | | Motif Instance | PKLPSL | | Bait Uniprot Accession | P98164 | | Bait Uniprot Identifier | LRP2_HUMAN | | Bait Gene Name | LRP2 | | Sequence Position | 4461-4466 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; Y2H; Pull down(GST tag) | | Interaction ID | 21958 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22649097, 11095640 | | Comments | The PxLPxI/L motif (4461-4466) of human Low-density lipoprotein receptor-related protein 2 (Megalin) recognized by Ankyrin repeat family A protein 2 (ANKRA2) for binding to the ankyrin repeat domain |
Record No : 34 |
| Instance ID | 11963 | | Regular Expression | PxxxRxxKP | | Motif Instance | PSIDRSTKP | | Bait Uniprot Accession | Q60787 | | Bait Uniprot Identifier | LCP2_MOUSE | | Bait Gene Name | Lcp2 | | Sequence Position | 233-241 | | Critical Residues | P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Alanine-scanning mutagenesis; SPOT Analysis | | Interaction ID | 21963 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12176364, 12620234 | | Comments | The high-affinity atypical R-X-X-K binding motif in mouse SLP-76 tyrosine phosphoprotein for binding the Gads SH3 Domain |
Record No : 35 |
| Instance ID | 11986 | | Regular Expression | NPx[FY] | | Motif Instance | NPAY | | Bait Uniprot Accession | O70263 | | Bait Uniprot Identifier | LNX1_MOUSE | | Bait Gene Name | Lnx1 | | Sequence Position | 185-188 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 21986 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9535908 | | Comments | High-affinity binding of the Mouse Numb phosphotyrosine-binding (PTB) domain to the NPXY motif of mouse E3 ubiquitin-protein ligase Lnx1 |
Record No : 36 |
| Instance ID | 11995 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | P13285 | | Bait Uniprot Identifier | LMP2_EBVB9 | | Bait Gene Name | LMP2 | | Sequence Position | 98-101 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 21995 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11046148 | | Comments | The PY motif of Epstein-Barr virus Latent membrane protein 2 (LMP2) binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4L/KIAA0439 and may thereby regulate B-cell receptor (BCR) signaling |
Record No : 37 |
| Instance ID | 12202 | | Regular Expression | PRPxxR | | Motif Instance | PRPAAR | | Bait Uniprot Accession | P16636 | | Bait Uniprot Identifier | LYOX_RAT | | Bait Gene Name | Lox | | Sequence Position | 111-116 | | Critical Residues | P1; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag); Competition binding | | Interaction ID | 22202 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 24167568 | | Comments | Atypical SH3 domain binding motif in rat Protein-lysine 6-oxidase (Lox) that binds the SH3-B domain of rat SH3 domain-containing kinase-binding protein 1 (Sh3kbp1) |
Record No : 38 |
| Instance ID | 12203 | | Regular Expression | PRPxxR | | Motif Instance | PRPTAR | | Bait Uniprot Accession | P28300 | | Bait Uniprot Identifier | LYOX_HUMAN | | Bait Gene Name | LOX | | Sequence Position | 117-122 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 22203 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 24167568 | | Comments | Atypical SH3 domain binding motif in human Protein-lysine 6-oxidase (LOX) that binds the SH3-B domain of human SH3 domain-containing kinase-binding protein 1 (SH3KBP1/CIN85) |
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