|
Total : 106 Records
Record No : 1 |
| Instance ID | 10010 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSISLP | | Bait Uniprot Accession | Q99683 | | Bait Uniprot Identifier | M3K5_HUMAN | | Bait Gene Name | MAP3K5 | | Sequence Position | 963-968 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20010 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10411906 | | Comments | 14-3-3 binding motif in human ASK1 (or MAP3K5) that binds 14-3-3 protein zeta |
Record No : 2 |
| Instance ID | 10014 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RTISAP | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Sequence Position | 364-369 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20014 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16943424, 16227609 | | Comments | Consensus sequence (pS367) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein epsilon |
Record No : 3 |
| Instance ID | 10015 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RTISAP | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Sequence Position | 364-369 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20015 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16943424, 16227609 | | Comments | Consensus sequence (pS367) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein gamma |
Record No : 4 |
| Instance ID | 10016 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RTISAP | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Sequence Position | 364-369 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20016 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16943424, 16227609 | | Comments | Consensus sequence (pS367) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein theta |
Record No : 5 |
| Instance ID | 10017 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RTISAP | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Sequence Position | 364-369 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20017 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16943424, 16227609 | | Comments | Consensus sequence (pS367) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein beta |
Record No : 6 |
| Instance ID | 10018 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RTISAP | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Sequence Position | 364-369 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20018 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16943424, 16227609 | | Comments | Consensus sequence (pS367) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein zeta |
Record No : 7 |
| Instance ID | 10019 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RTISAP | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Sequence Position | 364-369 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20019 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16943424, 16227609 | | Comments | Consensus sequence (pS367) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein eta |
Record No : 8 |
| Instance ID | 10027 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RTESSP | | Bait Uniprot Accession | P08965 | | Bait Uniprot Identifier | MEI2_SCHPO | | Bait Gene Name | mei2 | | Sequence Position | 435-440 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Competition binding; Mutation analysis | | Interaction ID | 20027 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11818066 | | Comments | Rad24p, a 14-3-3 protein, functions as a negative factor for meiosis by antagonizing the binding of RNA to the phosphorylated form of fission yeast meiotic regulator Mei2p at Ser438 |
Record No : 9 |
| Instance ID | 10038 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RRSLTVG | | Bait Uniprot Accession | P08965 | | Bait Uniprot Identifier | MEI2_SCHPO | | Bait Gene Name | mei2 | | Sequence Position | 523-529 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Thr-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Y2H; Competition binding; Mutation analysis | | Interaction ID | 20038 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11818066 | | Comments | Rad24p, a 14-3-3 protein, functions as a negative factor for meiosis by antagonizing the binding of RNA to the phosphorylated form of fission yeast meiotic regulator Mei2p at Thr527 |
Record No : 10 |
| Instance ID | 10073 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | HSLSTS | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Sequence Position | 339-344 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20073 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16943424 | | Comments | Consensus sequence (pS342) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein epsilon |
Record No : 11 |
| Instance ID | 10074 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | HSLSTS | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Sequence Position | 339-344 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20074 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16943424 | | Comments | Consensus sequence (pS342) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein gamma |
Record No : 12 |
| Instance ID | 10075 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | HSLSTS | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Sequence Position | 339-344 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20075 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16943424 | | Comments | Consensus sequence (pS342) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein theta |
Record No : 13 |
| Instance ID | 10076 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | HSLSTS | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Sequence Position | 339-344 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20076 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16943424 | | Comments | Consensus sequence (pS342) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein beta |
Record No : 14 |
| Instance ID | 10077 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | HSLSTS | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Sequence Position | 339-344 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20077 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16943424 | | Comments | Consensus sequence (pS342) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein zeta |
Record No : 15 |
| Instance ID | 10078 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | HSLSTS | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Sequence Position | 339-344 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Competition binding; Mutation analysis | | Interaction ID | 20078 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16943424 | | Comments | Consensus sequence (pS342) for binding of 14-3-3 proteins in human p53-binding protein Mdm4 that mediates binding to 14-3-3 protein eta |
Record No : 16 |
| Instance ID | 10081 | | Regular Expression | [IL]xx[^P][^P][^P][^P]Rxxxxx[IL]xx[^P][^P][ILV][ILM] | | Motif Instance | LRRKGRNRSDRASLVTMHIL | | Bait Uniprot Accession | Q8VIM5 | | Bait Uniprot Identifier | MYCD_MOUSE | | Bait Gene Name | Myocd | | Sequence Position | 64-83 | | Critical Residues | P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Fluorescence polarization spectroscopy; GFP tag; Pull down; Alanine scanning | | Interaction ID | 20081 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18025109 | | Comments | RPEL motif (64-83) in mouse Myocardin that binds to the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 17 |
| Instance ID | 10082 | | Regular Expression | [IL]xx[^P][^P][^P][^P]Rxxxxx[IL]xx[^P][^P][ILV][ILM] | | Motif Instance | LNEKIAQRPGPMELVEKNIL | | Bait Uniprot Accession | Q9ULH7 | | Bait Uniprot Identifier | MKL2_HUMAN | | Bait Gene Name | MKL2 | | Sequence Position | 130-149 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 20082 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14565952 | | Comments | RPEL motif (130-149) in human Myocardin-related transcription factor MKL2 that binds to the hydrophobic cleft formed by subdomains 1 and 3 of human Alpha-actin-2 |
Record No : 18 |
| Instance ID | 10083 | | Regular Expression | [IL]xx[^P][^P][^P][^P]Rxxxxx[IL]xx[^P][^P][ILV][ILM] | | Motif Instance | LNEKIALRPGPLELVEKNIL | | Bait Uniprot Accession | Q8VIM5 | | Bait Uniprot Identifier | MYCD_MOUSE | | Bait Gene Name | Myocd | | Sequence Position | 108-127 | | Critical Residues | P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Fluorescence polarization spectroscopy; GFP tag; Pull down; Alanine scanning | | Interaction ID | 20083 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18025109 | | Comments | RPEL motif (108-127) in mouse Myocardin that binds to the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 19 |
| Instance ID | 10084 | | Regular Expression | [IL]xx[^P][^P][^P][^P]Rxxxxx[IL]xx[^P][^P][ILV][ILM] | | Motif Instance | LQLKLQQRRTREELVSQGIM | | Bait Uniprot Accession | Q8K4J6 | | Bait Uniprot Identifier | MKL1_MOUSE | | Bait Gene Name | Mkl1 | | Sequence Position | 17-36 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Fluorescence polarization spectroscopy; GFP tag; Pull down; Alanine scanning; structure based prediction; Molecular sieving; circular dichroism; Co-IP; Colocalization; Sequence based prediction | | Interaction ID | 20084 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18025109, 21673315, 17588931, 12732141, 19008859 | | Comments | RPEL motif (17-36) in mouse Myocardin-related transcription factor Mkl1 that binds to the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 20 |
| Instance ID | 10085 | | Regular Expression | [IL]xx[^P][^P][^P][^P]Rxxxxx[IL]xx[^P][^P][ILV][ILM] | | Motif Instance | LKRKIRSRPERAELVRMHIL | | Bait Uniprot Accession | Q8K4J6 | | Bait Uniprot Identifier | MKL1_MOUSE | | Bait Gene Name | Mkl1 | | Sequence Position | 61-80 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Fluorescence polarization spectroscopy; GFP tag; Pull down; Alanine scanning; structure based prediction; Molecular sieving; circular dichroism; Colocalization; Co-IP; Sequence based prediction | | Interaction ID | 20085 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18025109, 21673315, 20818336, 17588931, 12732141, 19008859 | | Comments | RPEL motif (61-80) in mouse Myocardin-related transcription factor Mkl1 that binds to the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 21 |
| Instance ID | 10086 | | Regular Expression | [IL]xx[^P][^P][^P][^P]Rxxxxx[IL]xx[^P][^P][ILV][ILM] | | Motif Instance | LNEKIAQRPGPMELVEKNIL | | Bait Uniprot Accession | Q8K4J6 | | Bait Uniprot Identifier | MKL1_MOUSE | | Bait Gene Name | Mkl1 | | Sequence Position | 105-124 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Fluorescence polarization spectroscopy; GFP tag; Pull down; Alanine scanning; structure based prediction; Molecular sieving; circular dichroism; Co-IP; Colocalization; Sequence based prediction | | Interaction ID | 20086 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18025109, 21673315, 17588931, 12732141, 19008859 | | Comments | RPEL motif (105-124) in mouse Myocardin-related transcription factor Mkl1 that binds to the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 22 |
| Instance ID | 10087 | | Regular Expression | [IL]xx[^P][^P][^P][^P]Rxxxxx[IL]xx[^P][^P][ILV][ILM] | | Motif Instance | LQLRLQQRRTQEQLANQGLI | | Bait Uniprot Accession | Q8VIM5 | | Bait Uniprot Identifier | MYCD_MOUSE | | Bait Gene Name | Myocd | | Sequence Position | 20-39 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Fluorescence polarization spectroscopy; GFP tag; Pull down; Alanine scanning | | Interaction ID | 20087 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18025109 | | Comments | RPEL motif (20-39) in mouse Myocardin that binds to the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 23 |
| Instance ID | 10111 | | Regular Expression | [^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS] | | Motif Instance | GEDMLNAIRRGVKLKKT | | Bait Uniprot Accession | O43312 | | Bait Uniprot Identifier | MTSS1_HUMAN | | Bait Gene Name | MTSS1 | | Sequence Position | 728-744 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Structure based prediction; ITC; Sequence based prediction; X-ray crystallography | | Interaction ID | 20111 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17292833, 16275905 | | Comments | The WH2 motif in human Metastasis suppressor protein 1 that mediates its interaction with the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 24 |
| Instance ID | 10226 | | Regular Expression | [ED]x{0,2}[ED]x{0,2}[EDQ]x{0,1}[YF]$ | | Motif Instance | EEQEEY | | Bait Uniprot Accession | Q15691 | | Bait Uniprot Identifier | MARE1_HUMAN | | Bait Gene Name | MAPRE1 | | Sequence Position | 263-268 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | SPR; Co-IP; Pull down; Mutation analysis; X-ray crystallography; ITC | | Interaction ID | 20226 | | Interacting Domain | CAP-Gly domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16949363, 16148041, 16109370, 16949363 | | Comments | The flexible tail from the carboxy-terminal dimerization domain of human EB1 (MAPRE1) that negatively regulates EB1 activity and binds to the microtubule binding (CAP-Gly) domain of the dynactin subunit p150Glued, an allosteric activator that relieves its auto-inhibited conformation |
Record No : 25 |
| Instance ID | 10279 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | PLDLS | | Bait Uniprot Accession | Q03112 | | Bait Uniprot Identifier | EVI1_HUMAN | | Bait Gene Name | MECOM | | Sequence Position | 584-588 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning | | Interaction ID | 20279 | | Interacting Domain | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | | Disease Association(s) | Chronic myeloid leukemia | | Inhibitor(s) | Unknown | | Reference(s) | 11965542 | | Comments | The t(3;21) fusion product, AML1/Evi-1 blocks AML1-induced transactivation by recruiting CtBP through the PxDLS motif |
Record No : 26 |
| Instance ID | 10475 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | VRVVLFLQKVWRGTLARMR | | Bait Uniprot Accession | Q63357 | | Bait Uniprot Identifier | MYO1D_RAT | | Bait Gene Name | Myo1d | | Sequence Position | 699-717 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Co-IP; Overlay assay | | Interaction ID | 20475 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8034741 | | Comments | The Calmodulin binding IQ motif of the rat Unconventional Myosin heavy chain myr 4 (Myo1d) that binds to the apo C-domain of rat Calmodulin (CaM) |
Record No : 27 |
| Instance ID | 10482 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | TLAAIKIQRTYRGWLLVREC | | Bait Uniprot Accession | P22467 | | Bait Uniprot Identifier | MYOA_DICDI | | Bait Gene Name | myoA | | Sequence Position | 746-765 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | ITC; Cosedimentation; Mutation analysis; Western blot | | Interaction ID | 20482 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21671662 | | Comments | Interaction of Dictyostelium discoideum Calmodulin (CaM) with the IQ motif of Myosin IA heavy chain |
Record No : 28 |
| Instance ID | 10483 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | PRIVTLIQKTWRGYRARSK | | Bait Uniprot Accession | Q03479 | | Bait Uniprot Identifier | MYOE_DICDI | | Bait Gene Name | myoE | | Sequence Position | 697-715 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | ITC; Cosedimentation; Mutation analysis; Western blot | | Interaction ID | 20483 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21671662 | | Comments | Interaction of Dictyostelium discoideum Calmodulin (CaM) with the IQ motif (697-715) of Myosin IE heavy chain |
Record No : 29 |
| Instance ID | 10484 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | RKAAIKIQLFYRSYRYKKWF | | Bait Uniprot Accession | Q03479 | | Bait Uniprot Identifier | MYOE_DICDI | | Bait Gene Name | myoE | | Sequence Position | 719-738 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | ITC; Cosedimentation; Mutation analysis; Western blot | | Interaction ID | 20484 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21671662 | | Comments | Interaction of Dictyostelium discoideum Calmodulin (CaM) with the IQ motif (719-738) of Myosin IE heavy chain |
Record No : 30 |
| Instance ID | 10485 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | LYCVVIIQKNYRAFLLRRRF | | Bait Uniprot Accession | Q9HD67 | | Bait Uniprot Identifier | MYO10_HUMAN | | Bait Gene Name | MYO10 | | Sequence Position | 766-785 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Comigration in gel electrophoresis; Competition binding | | Interaction ID | 20485 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20731332 | | Comments | Interaction of Calmodulin (CALM1) with the IQ motif (766-785) of human Unconventional myosin-10 |
Record No : 31 |
| Instance ID | 10486 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | KKAAIVFQKQLRGQIARRVY | | Bait Uniprot Accession | Q9HD67 | | Bait Uniprot Identifier | MYO10_HUMAN | | Bait Gene Name | MYO10 | | Sequence Position | 789-808 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Comigration in gel electrophoresis; Competition binding | | Interaction ID | 20486 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20731332 | | Comments | Interaction of Calmodulin (CALM1) with the IQ motif (789-808) of human Unconventional myosin-10 |
Record No : 32 |
| Instance ID | 10487 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | SQAIKYLQNNIKGFIIRQRV | | Bait Uniprot Accession | P19524 | | Bait Uniprot Identifier | MYO2_YEAST | | Bait Gene Name | MYO2 | | Sequence Position | 808-827 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | FRET; X-ray crystallography | | Interaction ID | 20487 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16120677 | | Comments | Calmodulin-like myosin light chain MLC1 binds to the IQ motif (808-827) of Myosin-2, a myosin V from Saccharomyces cerevisiae |
Record No : 33 |
| Instance ID | 10488 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | VNCATLLQAAYRGHSIRAN | | Bait Uniprot Accession | P19524 | | Bait Uniprot Identifier | MYO2_YEAST | | Bait Gene Name | MYO2 | | Sequence Position | 833-851 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | FRET; X-ray crystallography | | Interaction ID | 20488 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16120677 | | Comments | Calmodulin-like myosin light chain MLC1 binds to the IQ motif (833-851) of Myosin-2, a myosin V from Saccharomyces cerevisiae |
Record No : 34 |
| Instance ID | 10493 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | KRSAICIQSWWRGTLGRRKA | | Bait Uniprot Accession | Q9WTI7 | | Bait Uniprot Identifier | MYO1C_MOUSE | | Bait Gene Name | Myo1c | | Sequence Position | 758-777 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | FRET; Fluorescence polarization spectroscopy; Sedimentation Assay | | Interaction ID | 20493 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17910470 | | Comments | The Calmodulin binding IQ motif (758-777) of mouse Unconventional myosin-Ic that binds to chicken Calmodulin (CaM) |
Record No : 35 |
| Instance ID | 10497 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | QSLATKIQAAWRGFHWRQKF | | Bait Uniprot Accession | Q9WTI7 | | Bait Uniprot Identifier | MYO1C_MOUSE | | Bait Gene Name | Myo1c | | Sequence Position | 735-754 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | FRET; Fluorescence polarization spectroscopy | | Interaction ID | 20497 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17910470 | | Comments | The Calmodulin binding IQ motif (735-754) of mouse Unconventional myosin-Ic that binds to chicken Calmodulin (CaM) |
Record No : 36 |
| Instance ID | 10519 | | Regular Expression | [KR][IV][LV]xxxxxP | | Motif Instance | KVLHMSLNP | | Bait Uniprot Accession | Q9Y6D9 | | Bait Uniprot Identifier | MD1L1_HUMAN | | Bait Gene Name | MAD1L1 | | Sequence Position | 541-549 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20519 | | Interacting Domain | HORMA domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12006501 | | Comments | MAD2 binding motif in human Mitotic spindle assembly checkpoint protein MAD1 that interacts with Mitotic spindle assembly checkpoint protein MAD2A |
Record No : 37 |
| Instance ID | 10522 | | Regular Expression | [KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF] | | Motif Instance | RNTKNLSLDI | | Bait Uniprot Accession | P38590 | | Bait Uniprot Identifier | MSG5_YEAST | | Bait Gene Name | MSG5 | | Sequence Position | 29-38 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Fluorescence polarization spectroscopy; X-ray crystallography | | Interaction ID | 20522 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16364919 | | Comments | Saccharomyces cerevisiae Tyrosine-protein phosphatase MSG5 has a docking motif that selectively binds the yeast Mitogen-activated protein kinase FUS3 |
Record No : 38 |
| Instance ID | 10529 | | Regular Expression | [KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF] | | Motif Instance | RKPDLRVVI | | Bait Uniprot Accession | Q02078 | | Bait Uniprot Identifier | MEF2A_HUMAN | | Bait Gene Name | MEF2A | | Sequence Position | 269-277 | | Critical Residues | P9 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Protein Kinase Assay | | Interaction ID | 20529 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15132737, 10330143 | | Comments | Mouse ERK5 is targeted to human myocyte enhancer factor 2A (MEF2A) through a MAPK docking motif |
Record No : 39 |
| Instance ID | 10534 | | Regular Expression | [KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF] | | Motif Instance | KKPTPIQL | | Bait Uniprot Accession | Q02750 | | Bait Uniprot Identifier | MP2K1_HUMAN | | Bait Gene Name | MAP2K1 | | Sequence Position | 4-11 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag) | | Interaction ID | 20534 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11134045 | | Comments | The MAPK-docking site in MAPK/ERK kinase 1 (MEK1/MAP kinase kinase 1) mediates Mitogen-activated protein kinase 3 (MAPK3/ERK1) binding to MEK1 |
Record No : 40 |
| Instance ID | 10544 | | Regular Expression | PxLxP | | Motif Instance | PKLAP | | Bait Uniprot Accession | Q8IWI9 | | Bait Uniprot Identifier | MGAP_HUMAN | | Bait Gene Name | MGA | | Sequence Position | 2948-2952 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation disrupting interaction; Mutation analysis; Y2H | | Interaction ID | 20544 | | Interacting Domain | MYND domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11733528 | | Comments | The conserved Mynd domain of human protein BS69 (ZMYND11) binds the the Myc-related cellular protein MGA through a PxLxP motif (2948-2952) |
Record No : 41 |
| Instance ID | 10545 | | Regular Expression | PxLxP | | Motif Instance | PCLAP | | Bait Uniprot Accession | Q8IWI9 | | Bait Uniprot Identifier | MGAP_HUMAN | | Bait Gene Name | MGA | | Sequence Position | 2973-2977 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation disrupting interaction; Mutation analysis; Y2H | | Interaction ID | 20545 | | Interacting Domain | MYND domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11733528 | | Comments | The conserved Mynd domain of human protein BS69 (ZMYND11) binds the the Myc-related cellular protein MGA through a PxLxP motif (2973-2977) |
Record No : 42 |
| Instance ID | 10573 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | ILTSLLQ | | Bait Uniprot Accession | Q15648 | | Bait Uniprot Identifier | MED1_HUMAN | | Bait Gene Name | MED1 | | Sequence Position | 603-609 | | Critical Residues | P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20573 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12556447 | | Comments | The NR box motif (603-609) of human Mediator complex subunit 1 (MED1/TRAP220) that is necessary for binding the human Peroxisome proliferator-activated receptor gamma (PPARG) |
Record No : 43 |
| Instance ID | 10577 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | MLMNLLK | | Bait Uniprot Accession | Q15648 | | Bait Uniprot Identifier | MED1_HUMAN | | Bait Gene Name | MED1 | | Sequence Position | 644-650 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20577 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15065852 | | Comments | The NR box motif (644-650) of human Mediator complex subunit 1 (MED1/TRAP220) that is necessary for binding the rat Vitamin D3 receptor (Vdr) |
Record No : 44 |
| Instance ID | 10603 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | SQLNPNAVAFVPG | | Bait Uniprot Accession | P23226 | | Bait Uniprot Identifier | MA205_DROME | | Bait Gene Name | Map205 | | Sequence Position | 234-246 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 20603 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16554297 | | Comments | The MLLE/PABC domain of human Polyadenylate-binding protein 1 (PABP1/PABPC1/PABPC2) binds to the N-terminal PAM2 motif of Drosophila microtubule-associated protein Map205 |
Record No : 45 |
| Instance ID | 10604 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | SQLNPNAVAFVPG | | Bait Uniprot Accession | P23226 | | Bait Uniprot Identifier | MA205_DROME | | Bait Gene Name | Map205 | | Sequence Position | 234-246 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; ITC | | Interaction ID | 20604 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16554297 | | Comments | The MLLE/PABC domain of rat E3 ubiquitin-protein ligase Ubr5 binds to the N-terminal PAM2 motif of Drosophila microtubule-associated protein Map205 |
Record No : 46 |
| Instance ID | 10623 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QSSLLSFFSK | | Bait Uniprot Accession | Q03834 | | Bait Uniprot Identifier | MSH6_YEAST | | Bait Gene Name | MSH6 | | Sequence Position | 27-36 | | Critical Residues | P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 20623 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11062484 | | Comments | The N-terminal PCNA binding PIP box motif of Saccharomyces cerevisiae DNA mismatch repair protein MSH6 that mediates interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30) |
Record No : 47 |
| Instance ID | 10648 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | LLETDV | | Bait Uniprot Accession | Q9Q8F7 | | Bait Uniprot Identifier | Q9Q8F7_MYXVL | | Bait Gene Name | m147R | | Sequence Position | 283-288 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Display technology | | Interaction ID | 20648 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18828675 | | Comments | C-terminal class 1 PDZ-binding motif in the M147R protein of Myxoma virus that binds to the human Scribble (SCRIB) PDZ domain |
Record No : 48 |
| Instance ID | 10687 | | Regular Expression | xxx[DE]x[ACVILF]$ | | Motif Instance | VKVDSV | | Bait Uniprot Accession | P48039 | | Bait Uniprot Identifier | MTR1A_HUMAN | | Bait Gene Name | MTNR1A | | Sequence Position | 345-350 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | NMR | | Interaction ID | 20687 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10331866 | | Comments | The Class 2 PDZ-binding motif of human Melatonin receptor type 1A (MTNR1A) that binds to rat nNOS PDZ domain |
Record No : 49 |
| Instance ID | 10722 | | Regular Expression | xP[TS]APx | | Motif Instance | IPSAPL | | Bait Uniprot Accession | O60291 | | Bait Uniprot Identifier | MGRN1_HUMAN | | Bait Gene Name | MGRN1 | | Sequence Position | 405-410 | | Critical Residues | P2; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down; Co-IP; Classical fluorescence spectroscopy; Y2H | | Interaction ID | 20722 | | Interacting Domain | UEV domain | | Disease Association(s) | Spongiform Neurodegeneration | | Inhibitor(s) | Unknown | | Reference(s) | 17229889 | | Comments | Spongiform neurodegeneration-associated E3 ubiquitin-protein ligase Mahogunin (MGRN1) ubiquitylates human Tumor susceptibility gene 101 protein (TSG101) and thereby regulates endosomal trafficking |
Record No : 50 |
| Instance ID | 10759 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | LHPNPMY | | Bait Uniprot Accession | Q61006 | | Bait Uniprot Identifier | MUSK_MOUSE | | Bait Gene Name | Musk | | Sequence Position | 547-553 | | Critical Residues | P1; P2; P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | Protein kinase assay; X-ray crystallography | | Interaction ID | 20759 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20603078 | | Comments | The mouse cytoplasmic adaptor protein Dok7 activates the mouse Muscle-specific tyrosine-protein kinase receptor Musk via interaction of its phosphotyrosine-binding (PTB) domain with a phosphopeptide motif in Musk |
Record No : 51 |
| Instance ID | 10782 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LKCFE | | Bait Uniprot Accession | Q99683 | | Bait Uniprot Identifier | M3K5_HUMAN | | Bait Gene Name | MAP3K5 | | Sequence Position | 916-920 | | Critical Residues | P1; P2; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag) | | Interaction ID | 20782 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15210709 | | Comments | The Rb-binding LxCxE motif in the Human apoptosis signal-regulating kinase ASK1 (MAP3K5) that mediates binding to the human retinoblastoma protein (RB) |
Record No : 52 |
| Instance ID | 10794 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LACSE | | Bait Uniprot Accession | Q98178 | | Bait Uniprot Identifier | Q98178_MCV1 | | Bait Gene Name | MC007L | | Sequence Position | 178-182 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20794 | | Interacting Domain | B domain | | Disease Association(s) | Molluscum contagiosum | | Inhibitor(s) | Unknown | | Reference(s) | 18701596 | | Comments | The MC007L protein of Molluscum contagiosum virus (MCV) targets human retinoblastoma protein (RB) via a conserved LxCxE motif |
Record No : 53 |
| Instance ID | 10823 | | Regular Expression | [LIVMP]x{0,2}(T)Pxx([ST]) | | Motif Instance | LLPTPPLS | | Bait Uniprot Accession | P01106 | | Bait Uniprot Identifier | MYC_HUMAN | | Bait Gene Name | MYC | | Sequence Position | 55-62 | | Critical Residues | P4; P8 | | Motif PTM(s) | Phosphorylation at Thr-P4 & Ser-P8 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Competition binding; Co-IP; Ubiquitinase assay | | Interaction ID | 20823 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15992821, 15103331 | | Comments | Phosphorylation-dependent degradation of Human c-Myc is mediated by the F-box protein F box protein FBXW7 of the SCF complex in a manner dependent on the phosphorylation of threonine-58 and serine-62 |
Record No : 54 |
| Instance ID | 10850 | | Regular Expression | (Y)xNx | | Motif Instance | YVNV | | Bait Uniprot Accession | P08581 | | Bait Uniprot Identifier | MET_HUMAN | | Bait Gene Name | MET | | Sequence Position | 1356-1359 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Beta turn | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20850 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11063574, 12475979 | | Comments | Phosphorylation of Tyr-1356 in Human Proto-oncogene c-Met creates a docking site for the SH2-domain of the human Adapter protein GRB2 |
Record No : 55 |
| Instance ID | 10879 | | Regular Expression | [RKY]xxPxxP | | Motif Instance | RTPPKSP | | Bait Uniprot Accession | P10636 | | Bait Uniprot Identifier | TAU_HUMAN | | Bait Gene Name | MAPT | | Sequence Position | 547-553 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20879 | | Interacting Domain | SH3 domain | | Disease Association(s) | Alzheimer's disease | | Inhibitor(s) | Unknown | | Reference(s) | 9763511 | | Comments | Proline-rich SH3-binding sequence in the amino terminus of human Microtubule-associated protein tau (MAPT) that interacts with the SH3 domain of human Tyrosine-protein kinase Fyn and may have a role in neuropathogenesis |
Record No : 56 |
| Instance ID | 10893 | | Regular Expression | PxxPx[KR] | | Motif Instance | PLSPSR | | Bait Uniprot Accession | P01106 | | Bait Uniprot Identifier | MYC_HUMAN | | Bait Gene Name | MYC | | Sequence Position | 60-65 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR; Y2H | | Interaction ID | 20893 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15992821 | | Comments | The consensus class II SH3-binding motif in the N terminus of the Human c-Myc oncoprotein interacts with the C-terminal SH3 domain of human BIN1, a ubiquitously expressed nucleocytoplasmic protein with features of a tumor suppressor |
Record No : 57 |
| Instance ID | 10925 | | Regular Expression | [LIV]xx[LM]LxAAx[FY][LI] | | Motif Instance | IQMLLEAADYL | | Bait Uniprot Accession | Q05195 | | Bait Uniprot Identifier | MAD1_HUMAN | | Bait Gene Name | MXD1 | | Sequence Position | 9-19 | | Critical Residues | P2; P6; P9 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | NMR; Mutation analysis | | Interaction ID | 20925 | | Interacting Domain | PAH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15235594, 11101889 | | Comments | The N-terminal region of human Max dimerization protein 1 (MXD1) binds the second paired amphipathic helix (PAH) domain (PAH2) of mouse Transcriptional corepressor Sin3a through a novel helical fold |
Record No : 58 |
| Instance ID | 10967 | | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | | Motif Instance | IVIED | | Bait Uniprot Accession | Q13330 | | Bait Uniprot Identifier | MTA1_HUMAN | | Bait Gene Name | MTA1 | | Sequence Position | 711-715 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Pull down(GST tag); Alanine scanning | | Interaction ID | 20967 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21965678 | | Comments | The SUMO-interacting motif (SIM) of human Metastasis-associated protein MTA1 that mediates interactions with human Small ubiquitin-related modifier 2 (SUMO2) |
Record No : 59 |
| Instance ID | 11002 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | ARPPPIGA | | Bait Uniprot Accession | Q07820 | | Bait Uniprot Identifier | MCL1_HUMAN | | Bait Gene Name | MCL1 | | Sequence Position | 77-84 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 21002 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22153077 | | Comments | The N-terminal region of ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif in human Induced myeloid leukemia cell differentiation protein MCL1 |
Record No : 60 |
| Instance ID | 11038 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | PSSSH | | Bait Uniprot Accession | Q00987 | | Bait Uniprot Identifier | MDM2_HUMAN | | Bait Gene Name | MDM2 | | Sequence Position | 147-151 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; Mutation analysis; Pull down; Classical fluorescence spectroscopy | | Interaction ID | 21038 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16474402 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (147-151) in human E3 ubiquitin-protein ligase MDM2 |
Record No : 61 |
| Instance ID | 11039 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | AGVSE | | Bait Uniprot Accession | Q00987 | | Bait Uniprot Identifier | MDM2_HUMAN | | Bait Gene Name | MDM2 | | Sequence Position | 226-230 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; ITC | | Interaction ID | 21039 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16402859 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (226-230) in human E3 ubiquitin-protein ligase MDM2 |
Record No : 62 |
| Instance ID | 11042 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | AQCST | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Sequence Position | 8-12 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Classical fluorescence spectroscopy; Pull down; Mutation analysis | | Interaction ID | 21042 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20713061 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (8-12) in human P53-binding protein MDM4/MDMX |
Record No : 63 |
| Instance ID | 11043 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | AHSSE | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Sequence Position | 398-402 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Classical fluorescence spectroscopy; Pull down; Mutation analysis; X-ray crystallography | | Interaction ID | 21043 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20713061 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (398-402) in human P53-binding protein MDM4/MDMX |
Record No : 64 |
| Instance ID | 11044 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | PSTSS | | Bait Uniprot Accession | Q00987 | | Bait Uniprot Identifier | MDM2_HUMAN | | Bait Gene Name | MDM2 | | Sequence Position | 397-401 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Classical fluorescence spectroscopy; Mutation analysis; X-ray crystallography | | Interaction ID | 21044 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20713061 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (397-401) in human E3 ubiquitin-protein ligase MDM2 |
Record No : 65 |
| Instance ID | 11045 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | ASQSQ | | Bait Uniprot Accession | Q00987 | | Bait Uniprot Identifier | MDM2_HUMAN | | Bait Gene Name | MDM2 | | Sequence Position | 385-389 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Classical fluorescence spectroscopy | | Interaction ID | 21045 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20713061 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (385-389) in human E3 ubiquitin-protein ligase MDM2 |
Record No : 66 |
| Instance ID | 11046 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | PCNSV | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Sequence Position | 388-392 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Classical fluorescence spectroscopy | | Interaction ID | 21046 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20713061 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (388-392) in human P53-binding protein MDM4/MDMX |
Record No : 67 |
| Instance ID | 11047 | | Regular Expression | [PA][^P][^FYWIL]S[^P] | | Motif Instance | AGASC | | Bait Uniprot Accession | O15151 | | Bait Uniprot Identifier | MDM4_HUMAN | | Bait Gene Name | MDM4 | | Sequence Position | 470-474 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Classical fluorescence spectroscopy | | Interaction ID | 21047 | | Interacting Domain | MATH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20713061 | | Comments | The N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (470-474) in human P53-binding protein MDM4/MDMX |
Record No : 68 |
| Instance ID | 11084 | | Regular Expression | xxx([ST])Px | | Motif Instance | LLPTPP | | Bait Uniprot Accession | P01106 | | Bait Uniprot Identifier | MYC_HUMAN | | Bait Gene Name | MYC | | Sequence Position | 55-60 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Western blot; Alanine scanning | | Interaction ID | 21084 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15048125 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Thr-58-Pro motif of human MYC proto-oncogene protein |
Record No : 69 |
| Instance ID | 11126 | | Regular Expression | xxx([ST])Px | | Motif Instance | GCDSPD | | Bait Uniprot Accession | Q8CFN5 | | Bait Uniprot Identifier | MEF2C_MOUSE | | Bait Gene Name | Mef2c | | Sequence Position | 95-100 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Mutation analysis; Western blot; Co-IP; Alanine scanning; Pull down | | Interaction ID | 21126 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20801874 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 interacts selectively with the phosphorylated Ser-98-Pro motif of mouse Myocyte-specific enhancer factor 2C (Mef2c) in skeletal muscle cells and acts as a regulator of muscle terminal differentiation |
Record No : 70 |
| Instance ID | 11128 | | Regular Expression | xxx([ST])Px | | Motif Instance | VGHSPE | | Bait Uniprot Accession | Q8CFN5 | | Bait Uniprot Identifier | MEF2C_MOUSE | | Bait Gene Name | Mef2c | | Sequence Position | 107-112 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Mutation analysis; Western blot; Co-IP; Alanine scanning; Pull down | | Interaction ID | 21128 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20801874 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 interacts selectively with the phosphorylated Ser-110-Pro motif of mouse Myocyte-specific enhancer factor 2C (Mef2c) in skeletal muscle cells and acts as a regulator of muscle terminal differentiation |
Record No : 71 |
| Instance ID | 11132 | | Regular Expression | xxx([ST])Px | | Motif Instance | EVESPT | | Bait Uniprot Accession | P06876 | | Bait Uniprot Identifier | MYB_MOUSE | | Bait Gene Name | Myb | | Sequence Position | 525-530 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Co-IP; Mutation analysis | | Interaction ID | 21132 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18359295 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Ser-528-Pro motif in mouse Transcriptional activator Myb |
Record No : 72 |
| Instance ID | 11152 | | Regular Expression | xxx([ST])Px | | Motif Instance | PPLSPS | | Bait Uniprot Accession | P01106 | | Bait Uniprot Identifier | MYC_HUMAN | | Bait Gene Name | MYC | | Sequence Position | 59-64 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Western blot; Alanine scanning | | Interaction ID | 21152 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15048125 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-62-Pro motif of human MYC proto-oncogene protein |
Record No : 73 |
| Instance ID | 11155 | | Regular Expression | xxx([ST])Px | | Motif Instance | VVRTPP | | Bait Uniprot Accession | P10636 | | Bait Uniprot Identifier | TAU_HUMAN | | Bait Gene Name | MAPT | | Sequence Position | 228-233 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | ELISA; Alanine scanning; Pull down | | Interaction ID | 21155 | | Interacting Domain | WW domain | | Disease Association(s) | Alzheimer's disease | | Inhibitor(s) | Unknown | | Reference(s) | 10391244 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 exhibits specific and high-affinity binding to the phosphorylated Thr-231-Pro motif of Isoform Tau-F (Tau-4) of human Microtubule-associated protein tau (MAPT) |
Record No : 74 |
| Instance ID | 11170 | | Regular Expression | xx(T)xx[DE]x | | Motif Instance | VPTQLDS | | Bait Uniprot Accession | Q9P7T4 | | Bait Uniprot Identifier | MRC1_SCHPO | | Bait Gene Name | mrc1 | | Sequence Position | 643-649 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Thr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 21170 | | Interacting Domain | FHA domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14585996 | | Comments | Phosphorylation of a threonine residue (T645) in DNA replication checkpoint mediator mrc1 mediates its association with Checkpoint kinase cds1 in fission yeast |
Record No : 75 |
| Instance ID | 11175 | | Regular Expression | [EN][FYLW][NSQ]xEE[ILMVF][^P][LIVMFA] | | Motif Instance | EFSLEEVLA | | Bait Uniprot Accession | P47074 | | Bait Uniprot Identifier | MAD3_YEAST | | Bait Gene Name | MAD3 | | Sequence Position | 378-386 | | Critical Residues | P1; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography; Pull down; Co-IP; Y2H; Mutation analysis | | Interaction ID | 21175 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17227844 | | Comments | The Gle2-binding-sequence (GLEBS) motif found in yeast Spindle assembly checkpoint component MAD3 protein binds to the WD40 domain of yeast Cell cycle arrest protein BUB3 |
Record No : 76 |
| Instance ID | 11203 | | Regular Expression | [ED][ED][ED]x[IV]Yx | | Motif Instance | IEDPVYG | | Bait Uniprot Accession | Q6RHR9 | | Bait Uniprot Identifier | MAGI1_MOUSE | | Bait Gene Name | Magi1 | | Sequence Position | 368-374 | | Critical Residues | P2; P3; P5; P6 | | Motif PTM(s) | Phosphorylation at Tyr-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed Mutagenesis; In-vitro assay using fluorogenic peptide probes | | Interaction ID | 21203 | | Interacting Domain | Catalytic domain of Ptprz | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21890632 | | Comments | Consensus sequence (368-374) for association with protein-tyrosine phosphatase receptor type zeta in mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Magi1) |
Record No : 77 |
| Instance ID | 11204 | | Regular Expression | [ED][ED][ED]x[IV]Yx | | Motif Instance | PGEPIYI | | Bait Uniprot Accession | Q6RHR9 | | Bait Uniprot Identifier | MAGI1_MOUSE | | Bait Gene Name | Magi1 | | Sequence Position | 853-859 | | Critical Residues | P2; P3; P5; P6 | | Motif PTM(s) | Phosphorylation at Tyr-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed Mutagenesis; In-vitro assay using fluorogenic peptide probes | | Interaction ID | 21204 | | Interacting Domain | Catalytic domain of Ptprz | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21890632 | | Comments | Consensus sequence (853-859) for association with protein-tyrosine phosphatase receptor type zeta in mouse Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Magi1) |
Record No : 78 |
| Instance ID | 11227 | | Regular Expression | [ST]x[VL]D | | Motif Instance | SSVD | | Bait Uniprot Accession | Q15648 | | Bait Uniprot Identifier | MED1_HUMAN | | Bait Gene Name | MED1 | | Sequence Position | 1370-1373 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21227 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22876914 | | Comments | Novel internal motif identified in human Mediator complex subunit 1 (MED1) that is recognized by human Glutaminase-interacting protein (GIP), also known as Tax-interacting protein 1 (TIP1) or Tax1-binding protein 3 (TAX1BP3), composed almost exclusively of a single PDZ domain |
Record No : 79 |
| Instance ID | 11229 | | Regular Expression | [ST]x[VL]D | | Motif Instance | SSVD | | Bait Uniprot Accession | Q8IUG5 | | Bait Uniprot Identifier | MY18B_HUMAN | | Bait Gene Name | MYO18B | | Sequence Position | 2389-2392 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21229 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22876914 | | Comments | Novel internal motif identified in human Unconventional myosin-XVIIIb (MYO18B) that is recognized by human Glutaminase-interacting protein (GIP), also known as Tax-interacting protein 1 (TIP1) or Tax1-binding protein 3 (TAX1BP3), composed almost exclusively of a single PDZ domain |
Record No : 80 |
| Instance ID | 11266 | | Regular Expression | KNTMTD | | Motif Instance | KNTMTD | | Bait Uniprot Accession | Q9Y4I1 | | Bait Uniprot Identifier | MYO5A_HUMAN | | Bait Gene Name | MYO5A | | Sequence Position | 1286-1291 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Peptide Competition Assay; NMR; ITC; SPR; Fluorescence anisotropy; Stopped-flow fluorescence spectroscopy | | Interaction ID | 21266 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17029413, 20889982 | | Comments | Noncanonical motif in human Unconventional myosin-Va (MYO5A) that may mediate its interaction with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2) |
Record No : 81 |
| Instance ID | 11314 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | SKSTQTV | | Bait Uniprot Accession | P27816 | | Bait Uniprot Identifier | MAP4_HUMAN | | Bait Gene Name | MAP4 | | Sequence Position | 801-807 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21314 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in human Microtubule-associated protein 4 (MAP4) that interacts with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8) |
Record No : 82 |
| Instance ID | 11315 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | SKSTQTV | | Bait Uniprot Accession | P27816 | | Bait Uniprot Identifier | MAP4_HUMAN | | Bait Gene Name | MAP4 | | Sequence Position | 801-807 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21315 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in human Microtubule-associated protein 4 (MAP4) that interacts with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2) |
Record No : 83 |
| Instance ID | 11316 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | QASTQTR | | Bait Uniprot Accession | P58340 | | Bait Uniprot Identifier | MLF1_HUMAN | | Bait Gene Name | MLF1 | | Sequence Position | 125-131 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21316 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in human Myeloid leukemia factor 1 (MLF1) that interacts with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8) |
Record No : 84 |
| Instance ID | 11317 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | QASTQTR | | Bait Uniprot Accession | P58340 | | Bait Uniprot Identifier | MLF1_HUMAN | | Bait Gene Name | MLF1 | | Sequence Position | 125-131 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21317 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in human Myeloid leukemia factor 1 (MLF1) that interacts with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2) |
Record No : 85 |
| Instance ID | 11755 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RTPPKSP | | Bait Uniprot Accession | P11137 | | Bait Uniprot Identifier | MTAP2_HUMAN | | Bait Gene Name | MAP2 | | Sequence Position | 1648-1654 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Thr-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; ELISA | | Interaction ID | 21755 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11546790 | | Comments | The SH3 domain-binding motif in human Microtubule-associated protein 2 [isoform MAP-2c (residues 292-298)] that binds the SH3 domain of human proto-oncogene c-Fyn [Phosphorylation of MAP-2c at this motif by ERK2 abolishes its interaction with Fyn] |
Record No : 86 |
| Instance ID | 11768 | | Regular Expression | PPxPxKxK | | Motif Instance | PPLPPKPK | | Bait Uniprot Accession | Q92918 | | Bait Uniprot Identifier | M4K1_HUMAN | | Bait Gene Name | MAP4K1 | | Sequence Position | 395-402 | | Critical Residues | P8 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR; CD; ITC | | Interaction ID | 21768 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19921743 | | Comments | The SH3 domain-binding motif in human HPK1 that binds the murine cortactin SH3 domain |
Record No : 87 |
| Instance ID | 11769 | | Regular Expression | PPxPxKxK | | Motif Instance | PPLPPKPK | | Bait Uniprot Accession | Q92918 | | Bait Uniprot Identifier | M4K1_HUMAN | | Bait Gene Name | MAP4K1 | | Sequence Position | 395-402 | | Critical Residues | P8 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | CD; GST-SH3 titration | | Interaction ID | 21769 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21287358, 10233887 | | Comments | The SH3 domain-binding motif in human HPK1 that binds the human HS1 SH3 domain |
Record No : 88 |
| Instance ID | 11792 | | Regular Expression | KYxLxP | | Motif Instance | KYRLSP | | Bait Uniprot Accession | Q8NEM0 | | Bait Uniprot Identifier | MCPH1_HUMAN | | Bait Gene Name | MCPH1 | | Sequence Position | 329-334 | | Critical Residues | P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Peptide binding assay (Fluorescence polarization); BiFC assay | | Interaction ID | 21792 | | Interacting Domain | TRF2-TRFH domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19287395 | | Comments | The TRF2-TRFH binding motif in human MCPH1 (Microcephalin) that interacts with the TRFH domain of human Telomeric repeat-binding factor 2 (TRF2) |
Record No : 89 |
| Instance ID | 11802 | | Regular Expression | [DE][LI]xCxE | | Motif Instance | DLYCHE | | Bait Uniprot Accession | Q98178 | | Bait Uniprot Identifier | Q98178_MCV1 | | Bait Gene Name | MC007L | | Sequence Position | 140-145 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 21802 | | Interacting Domain | B domain | | Disease Association(s) | Molluscum contagiosum | | Inhibitor(s) | Unknown | | Reference(s) | 18701596 | | Comments | The MC007L protein of Molluscum contagiosum virus (MCV) targets human retinoblastoma protein (RB) via a conserved LxCxE motif (140-145) |
Record No : 90 |
| Instance ID | 11920 | | Regular Expression | [DE][DE][GL]W | | Motif Instance | DELW | | Bait Uniprot Accession | P14780 | | Bait Uniprot Identifier | MMP9_HUMAN | | Bait Gene Name | MMP9 | | Sequence Position | 207-210 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine-scanning mutagenesis; SPOT Analysis | | Interaction ID | 21920 | | Interacting Domain | Alpha M I domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12824186 | | Comments | A negatively charged peptide motif within the catalytic domain of Matrix metalloproteinase-9 that mediates binding to Integrin alpha-M of leukocytes |
Record No : 91 |
| Instance ID | 11921 | | Regular Expression | [DE][DE][GL]W | | Motif Instance | DELW | | Bait Uniprot Accession | P08253 | | Bait Uniprot Identifier | MMP2_HUMAN | | Bait Gene Name | MMP2 | | Sequence Position | 210-213 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine-scanning mutagenesis; SPOT Analysis | | Interaction ID | 21921 | | Interacting Domain | Alpha M I domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12824186 | | Comments | A negatively charged peptide motif within the catalytic domain of Matrix metalloproteinase-2 that mediates binding to Integrin alpha-M of leukocytes |
Record No : 92 |
| Instance ID | 11923 | | Regular Expression | [DE][DE]x{1,2}[WF] | | Motif Instance | DERW | | Bait Uniprot Accession | P03956 | | Bait Uniprot Identifier | MMP1_HUMAN | | Bait Gene Name | MMP1 | | Sequence Position | 200-203 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine-scanning mutagenesis; SPOT Analysis | | Interaction ID | 21923 | | Interacting Domain | Alpha M I domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12824186 | | Comments | A negatively charged peptide motif within the catalytic domain of Matrix metalloproteinase-1 that mediates binding to Integrin alpha-M of leukocytes |
Record No : 93 |
| Instance ID | 11924 | | Regular Expression | [DE][DE]x{1,2}[WF] | | Motif Instance | DEQW | | Bait Uniprot Accession | P08254 | | Bait Uniprot Identifier | MMP3_HUMAN | | Bait Gene Name | MMP3 | | Sequence Position | 200-203 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine-scanning mutagenesis; SPOT Analysis | | Interaction ID | 21924 | | Interacting Domain | Alpha M I domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12824186 | | Comments | A negatively charged peptide motif within the catalytic domain of Matrix metalloproteinase-3 that mediates binding to Integrin alpha-M of leukocytes |
Record No : 94 |
| Instance ID | 11925 | | Regular Expression | [DE][DE]x{1,2}[WF] | | Motif Instance | DERW | | Bait Uniprot Accession | P09237 | | Bait Uniprot Identifier | MMP7_HUMAN | | Bait Gene Name | MMP7 | | Sequence Position | 195-198 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine-scanning mutagenesis; SPOT Analysis | | Interaction ID | 21925 | | Interacting Domain | Alpha M I domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12824186 | | Comments | A negatively charged peptide motif within the catalytic domain of Matrix metalloproteinase-7 that mediates binding to Integrin alpha-M of leukocytes |
Record No : 95 |
| Instance ID | 11926 | | Regular Expression | [DE][DE]x{1,2}[WF] | | Motif Instance | EETW | | Bait Uniprot Accession | P22894 | | Bait Uniprot Identifier | MMP8_HUMAN | | Bait Gene Name | MMP8 | | Sequence Position | 199-202 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine-scanning mutagenesis; SPOT Analysis | | Interaction ID | 21926 | | Interacting Domain | Alpha M I domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12824186 | | Comments | A negatively charged peptide motif within the catalytic domain of Matrix metalloproteinase-8 that mediates binding to Integrin alpha-M of leukocytes |
Record No : 96 |
| Instance ID | 11927 | | Regular Expression | [DE][DE]x{1,2}[WF] | | Motif Instance | DETW | | Bait Uniprot Accession | P45452 | | Bait Uniprot Identifier | MMP13_HUMAN | | Bait Gene Name | MMP13 | | Sequence Position | 204-207 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine-scanning mutagenesis; SPOT Analysis | | Interaction ID | 21927 | | Interacting Domain | Alpha M I domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12824186 | | Comments | A negatively charged peptide motif within the catalytic domain of Matrix metalloproteinase-13 that mediates binding to Integrin alpha-M of leukocytes |
Record No : 97 |
| Instance ID | 11928 | | Regular Expression | [DE][DE]x{1,2}[WF] | | Motif Instance | EDGF | | Bait Uniprot Accession | P05164 | | Bait Uniprot Identifier | PERM_HUMAN | | Bait Gene Name | MPO | | Sequence Position | 204-207 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine-scanning mutagenesis; SPOT Analysis | | Interaction ID | 21928 | | Interacting Domain | Alpha M I domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12824186 | | Comments | A negatively charged peptide motif within the catalytic domain of Myeloperoxidase that mediates binding to Integrin alpha-M of leukocytes |
Record No : 98 |
| Instance ID | 11945 | | Regular Expression | YxN | | Motif Instance | YSN | | Bait Uniprot Accession | P11137 | | Bait Uniprot Identifier | MTAP2_HUMAN | | Bait Gene Name | MAP2 | | Sequence Position | 67-69 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Ligand Overlay Assay; ELISA | | Interaction ID | 21945 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15536091 | | Comments | The phosphorylated YxN motif present in human Microtubule-associated protein 2 that specifically binds the SH2 domain of Growth factor receptor-bound protein 2 |
Record No : 99 |
| Instance ID | 11979 | | Regular Expression | [YF]xLxP | | Motif Instance | YRLSP | | Bait Uniprot Accession | Q8NEM0 | | Bait Uniprot Identifier | MCPH1_HUMAN | | Bait Gene Name | MCPH1 | | Sequence Position | 330-334 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21979 | | Interacting Domain | TRFH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19287395 | | Comments | The telomeric repeat binding factor (TRF) homology (TRFH) domain of human Telomeric repeat-binding factor 2 (TERF2/TRF2) recognizes and directly interacts with the [Y/F]XL motif in human Microcephalin (MCPH1) and regulates telomere maintenance |
Record No : 100 |
| Instance ID | 11989 | | Regular Expression | [LIV]xx[LM]LxAAx[FY][LI] | | Motif Instance | IETLLEAARFL | | Bait Uniprot Accession | O08789 | | Bait Uniprot Identifier | MNT_MOUSE | | Bait Gene Name | Mnt | | Sequence Position | 3-13 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21989 | | Interacting Domain | PAH2 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 9000049 | | Comments | The amino-terminal region of mouse Max-binding protein Mnt mediates interaction with mouse Transcriptional corepressor Sin3a and its deletion converts Mnt from a repressor to an activator |
Record No : 101 |
| Instance ID | 11997 | | Regular Expression | DYR | | Motif Instance | DYR | | Bait Uniprot Accession | P08581 | | Bait Uniprot Identifier | MET_HUMAN | | Bait Gene Name | MET | | Sequence Position | 1002-1004 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Phosphorylation at Tyr-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine-scanning mutagenesis; Co-IP; Far Western blotting; Competition binding | | Interaction ID | 21997 | | Interacting Domain | TKB Domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15123609 | | Comments | The ubiquitination of human Proto-oncogene c-Met by human Proto-oncogene c-Cbl requires the direct interaction of the c-Cbl Tyrosine Kinase binding (TKB) domain with conserved DpY(1003)R motif in the Met juxtamembrane domain leading to suppression of oncogenic activation |
Record No : 102 |
| Instance ID | 11998 | | Regular Expression | DYR | | Motif Instance | DYR | | Bait Uniprot Accession | P08581 | | Bait Uniprot Identifier | MET_HUMAN | | Bait Gene Name | MET | | Sequence Position | 1002-1004 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Phosphorylation at Tyr-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine-scanning mutagenesis; Pull down(GST tag) | | Interaction ID | 21998 | | Interacting Domain | TKB Domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15123609 | | Comments | The TKB domain of human E3 ubiquitin-protein ligase CBL-B binds to human Hepatocyte growth factor receptor (MET) via the conserved DpY(1003)R motif in the MET juxtamembrane domain |
Record No : 103 |
| Instance ID | 12006 | | Regular Expression | LVFNVVT | | Motif Instance | LVFNVVT | | Bait Uniprot Accession | P0CY08 | | Bait Uniprot Identifier | MTAL2_YEAST | | Bait Gene Name | MATALPHA2 | | Sequence Position | 114-120 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta strand | | Experimental Method(s) | Mutation analysis; Co-IP; Y2H | | Interaction ID | 22006 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8628280 | | Comments | The patch of predominantly hydrophobic residues within a region preceding the homeodomain of yeast Alpha-2 repressor (MATALPHA2) that specifies direct interaction with yeast transcription factor Mcm1 and is required for cooperative DNA binding with Mcm1 in vitro and for transcriptional repression in vivo |
Record No : 104 |
| Instance ID | 12025 | | Regular Expression | [RK]x{0,1}[VIL][^P][FWY] | | Motif Instance | RVSF | | Bait Uniprot Accession | P46013 | | Bait Uniprot Identifier | KI67_HUMAN | | Bait Gene Name | MKI67 | | Sequence Position | 505-508 | | Critical Residues | P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22025 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25012651 | | Comments | The RVxF motif in Antigen KI-67 (MKI67) that mediates its binding to protein phosphatase PP1-gamma catalytic subunit (PPP1CC) |
Record No : 105 |
| Instance ID | 12045 | | Regular Expression | FxxxVQxLTG | | Motif Instance | FMNVVQRLTG | | Bait Uniprot Accession | Q8LGD5 | | Bait Uniprot Identifier | MKS1_ARATH | | Bait Gene Name | MKS1 | | Sequence Position | 83-92 | | Critical Residues | P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 22045 | | Interacting Domain | WRKY domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22535423, 15990873 | | Comments | The VQ-motif in MAP kinase 4 substrate 1 (MKS1) of Arabidopsis thaliana that interacts specifically with the WRKY domain of Arabidopsis WRKY transcription factor 33 (WRKY33) |
Record No : 106 |
| Instance ID | 12046 | | Regular Expression | FxxxVQxLTG | | Motif Instance | FMNVVQRLTG | | Bait Uniprot Accession | Q8LGD5 | | Bait Uniprot Identifier | MKS1_ARATH | | Bait Gene Name | MKS1 | | Sequence Position | 83-92 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 22046 | | Interacting Domain | WRKY domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22535423, 15990873 | | Comments | The VQ-motif in MAP kinase 4 substrate 1 (MKS1) of Arabidopsis thaliana that interacts specifically with the WRKY domain of Arabidopsis WRKY transcription factor 25 (WRKY25) |
|
