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Total : 246 Records
Record No : 1 |
| Instance ID | 10011 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSHSYP | | Bait Uniprot Accession | P03076 | | Bait Uniprot Identifier | MT_POVM3 | | Bait Gene Name | Not Available | | Sequence Position | 254-259 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; SPR | | Interaction ID | 20011 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9428519 | | Comments | 14-3-3 binding motif in Murine polyomavirus Middle T antigen that binds 14-3-3 protein zeta |
Record No : 2 |
| Instance ID | 10098 | | Regular Expression | [^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS] | | Motif Instance | NPELQSAIGQGAALKHA | | Bait Uniprot Accession | P18281 | | Bait Uniprot Identifier | ACTO_ACACA | | Bait Gene Name | Not Available | | Sequence Position | 2-18 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Cross linking studies | | Interaction ID | 20098 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1464307 | | Comments | The actin binding site of Acanthamoeba protein Actobindin that mediates its interaction with the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 3 |
| Instance ID | 10175 | | Regular Expression | x[ILM]R$ | | Motif Instance | GMR | | Bait Uniprot Accession | P51955 | | Bait Uniprot Identifier | NEK2_HUMAN | | Bait Gene Name | NEK2 | | Sequence Position | 443-445 | | Critical Residues | P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Fluorescence microscopy; RNA interference; Mutation disrupting interaction; Co-IP; Mutation analysis; Immunodepleted Co-IP; Ubiquitinase assay;Western blot; Competition binding | | Interaction ID | 20175 | | Interacting Domain | Tetratricopeptide repeats | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23288039, 16648845 | | Comments | Early mitotic degradation of NIMA-related kinase 2A (Nek2A) depends on an exposed carboxy-terminal methionine-arginine (MR) dipeptide tail that binds to the Tetratricopeptide repeats of CDC27 |
Record No : 4 |
| Instance ID | 10245 | | Regular Expression | L[^P]{2,2}[HI]I[^P]{2,2}[IAV][IL] | | Motif Instance | LADHICQII | | Bait Uniprot Accession | O75376 | | Bait Uniprot Identifier | NCOR1_HUMAN | | Bait Gene Name | NCOR1 | | Sequence Position | 2051-2059 | | Critical Residues | P1; P5; P9 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography; Mutation analysis | | Interaction ID | 20245 | | Interacting Domain | AF-2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20581824 | | Comments | The first corepressor nuclear receptor (CORNR) box (2051-2059) found in human Nuclear receptor corepressor 1 that confers binding to the AF-2 domain of Rev-erbA-alpha |
Record No : 5 |
| Instance ID | 10246 | | Regular Expression | L[^P]{2,2}[HI]I[^P]{2,2}[IAV][IL] | | Motif Instance | LEDIIRKAL | | Bait Uniprot Accession | O75376 | | Bait Uniprot Identifier | NCOR1_HUMAN | | Bait Gene Name | NCOR1 | | Sequence Position | 2263-2271 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20246 | | Interacting Domain | AF-2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19913032 | | Comments | The second corepressor nuclear receptor (CORNR) box (2263-2271) found in human Nuclear receptor corepressor 1 that confers binding to the AF-2 domain of human Glucocorticoid receptor |
Record No : 6 |
| Instance ID | 10247 | | Regular Expression | L[^P]{2,2}[HI]I[^P]{2,2}[IAV][IL] | | Motif Instance | LAQHISEVI | | Bait Uniprot Accession | Q9Y618 | | Bait Uniprot Identifier | NCOR2_HUMAN | | Bait Gene Name | NCOR2 | | Sequence Position | 2143-2151 | | Critical Residues | P1; P5; P9 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Alanine scanning | | Interaction ID | 20247 | | Interacting Domain | AF-2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10617569 | | Comments | The first corepressor nuclear receptor (CORNR) box (2143-2151) found in human Nuclear receptor corepressor 2 (or SMRT) that confers binding to the AF-2 domain of PPAR-alpha |
Record No : 7 |
| Instance ID | 10248 | | Regular Expression | L[^P]{2,2}[HI]I[^P]{2,2}[IAV][IL] | | Motif Instance | LEAIIRKAL | | Bait Uniprot Accession | Q9Y618 | | Bait Uniprot Identifier | NCOR2_HUMAN | | Bait Gene Name | NCOR2 | | Sequence Position | 2350-2358 | | Critical Residues | P1; P5; P9 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography; Mutation analysis | | Interaction ID | 20248 | | Interacting Domain | AF-2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11845213 | | Comments | The second corepressor nuclear receptor (CORNR) box (2350-2358) found in human Nuclear receptor corepressor 2 (or SMRT) that confers binding to the AF-2 domain of PPAR-alpha |
Record No : 8 |
| Instance ID | 10266 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | PIDLS | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 440-444 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20266 | | Interacting Domain | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11509661 | | Comments | The PxDLS motif in human Nuclear factor RIP140 that serves as the site for interaction with the transcriptional corepressor CtBP |
Record No : 9 |
| Instance ID | 10284 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | PLDLS | | Bait Uniprot Accession | P03254 | | Bait Uniprot Identifier | E1A_ADE02 | | Bait Gene Name | Not Available | | Sequence Position | 279-283 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Pull down; Co-IP; Mutation analysis | | Interaction ID | 20284 | | Interacting Domain | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 7479821 | | Comments | C-terminal binding protein (CtBP) interacts with a conserved C-terminal motif of adenovirus E1A (exon 2), which may play a critical role in adenovirus replication and oncogenic transformation |
Record No : 10 |
| Instance ID | 10301 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RVLCF | | Bait Uniprot Accession | Q14207 | | Bait Uniprot Identifier | NPAT_HUMAN | | Bait Gene Name | NPAT | | Sequence Position | 1062-1066 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Colocalization | | Interaction ID | 20301 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10995387 | | Comments | The cyclin-binding RxL motif through which p220/NPAT links cyclical cyclin E/Cdk2 kinase activity to replication-dependent histone gene transcription |
Record No : 11 |
| Instance ID | 10325 | | Regular Expression | xNPFx | | Motif Instance | TNPFI | | Bait Uniprot Accession | P16554 | | Bait Uniprot Identifier | NUMB_DROME | | Bait Gene Name | numb | | Sequence Position | 538-542 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20325 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15155807 | | Comments | NPF motif in the carboxy-terminal sequence of Numb from Drosophila that associate with Drosophila EHD or Past1 |
Record No : 12 |
| Instance ID | 10329 | | Regular Expression | xNPFx | | Motif Instance | SNPFS | | Bait Uniprot Accession | Q9Y6R0 | | Bait Uniprot Identifier | NUMBL_HUMAN | | Bait Gene Name | NUMBL | | Sequence Position | 594-598 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20329 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9303539 | | Comments | Asn-Pro-Phe motif in human Numb-like protein that is responsible for the interaction with Eps15 homology (EH) domain of Epidermal growth factor receptor substrate 15 (EPS15) |
Record No : 13 |
| Instance ID | 10333 | | Regular Expression | xNPFx | | Motif Instance | TNPFS | | Bait Uniprot Accession | P49757 | | Bait Uniprot Identifier | NUMB_HUMAN | | Bait Gene Name | NUMB | | Sequence Position | 636-640 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Display technology; Mutation analysis | | Interaction ID | 20333 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9303539 | | Comments | Asn-Pro-Phe motif in human homolog of NUMB that is responsible for the interaction with Eps15 homology (EH) domain of Epidermal growth factor receptor substrate 15 (EPS15) |
Record No : 14 |
| Instance ID | 10481 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | NAAAAKIQASFRGHMARKKI | | Bait Uniprot Accession | P35722 | | Bait Uniprot Identifier | NEUG_BOVIN | | Bait Gene Name | NRGN | | Sequence Position | 27-46 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | NMR | | Interaction ID | 20481 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12689827 | | Comments | Interaction between calcium-free calmodulin and IQ motif of bovine Neurogranin |
Record No : 15 |
| Instance ID | 10491 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | ISAATRIQASFRMHKNRMA | | Bait Uniprot Accession | P05548 | | Bait Uniprot Identifier | CAVPT_BRALA | | Bait Gene Name | Not Available | | Sequence Position | 34-52 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | EMSA | | Interaction ID | 20491 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8900139 | | Comments | Calcium vector protein target (CaVPT) from Amphioxus binds to bovine brain Calmodulin (CaM) through the IQ motif |
Record No : 16 |
| Instance ID | 10501 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | VKKVIKVQSMMRALLARKRV | | Bait Uniprot Accession | P10676 | | Bait Uniprot Identifier | NINAC_DROME | | Bait Gene Name | ninaC | | Sequence Position | 1037-1057 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Co-IP; Classical fluorescence spectroscopy; Mutation analysis | | Interaction ID | 20501 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7556088 | | Comments | The Calmodulin binding IQ motif (1037-1057) of Drosophila NinaC that binds to Drosophila Calmodulin (CaM) |
Record No : 17 |
| Instance ID | 10502 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | DVAASKIQKAFRGFRDRVR | | Bait Uniprot Accession | P10676 | | Bait Uniprot Identifier | NINAC_DROME | | Bait Gene Name | ninaC | | Sequence Position | 1073-1091 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Classical fluorescence spectroscopy; Co-IP; Far Western blotting; Mutation analysis | | Interaction ID | 20502 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7556088 | | Comments | The Calmodulin binding IQ motif (1073-1091) of Drosophila NinaC that binds to Drosophila Calmodulin (CaM) |
Record No : 18 |
| Instance ID | 10541 | | Regular Expression | PxLxP | | Motif Instance | PNLVP | | Bait Uniprot Accession | P03255 | | Bait Uniprot Identifier | E1A_ADE05 | | Bait Gene Name | Not Available | | Sequence Position | 113-117 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation disrupting interaction; Mutation analysis; Co-IP; Pull down(GST tag) | | Interaction ID | 20541 | | Interacting Domain | MYND domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11733528 | | Comments | The conserved Mynd domain of human protein BS69 (ZMYND11) binds the adenoviral E1A oncoprotein through a PxLxP motif |
Record No : 19 |
| Instance ID | 10546 | | Regular Expression | PxLxP | | Motif Instance | PPLIP | | Bait Uniprot Accession | P70670 | | Bait Uniprot Identifier | NACAM_MOUSE | | Bait Gene Name | Naca | | Sequence Position | 1950-1954 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Colocalization; Mutation disrupting interaction; Mutation analysis; Co-IP | | Interaction ID | 20546 | | Interacting Domain | MYND domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12011100 | | Comments | The PxLxP motif in mouse skNAC (Naca) that is required for interaction with mouse Zinc finger protein BOP (Smyd1) |
Record No : 20 |
| Instance ID | 10547 | | Regular Expression | PPxLI | | Motif Instance | PPYLI | | Bait Uniprot Accession | Q9Y618 | | Bait Uniprot Identifier | NCOR2_HUMAN | | Bait Gene Name | NCOR2 | | Sequence Position | 1674-1678 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; Fluorescence polarization spectroscopy | | Interaction ID | 20547 | | Interacting Domain | MYND domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17560331 | | Comments | SMRT(NCOR2) recruitment by the MYND domain of AML1/ETO through the PPxLI motif (1674-1678) of SMRT plays a key role in AML1/ETO's ability to repress proliferation and differentiation of primary bone marrow cells as well as to enhance their self renewal |
Record No : 21 |
| Instance ID | 10548 | | Regular Expression | PPxLI | | Motif Instance | PPPLI | | Bait Uniprot Accession | O75376 | | Bait Uniprot Identifier | NCOR1_HUMAN | | Bait Gene Name | NCOR1 | | Sequence Position | 1033-1037 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; ITC; Fluorescence polarization spectroscopy | | Interaction ID | 20548 | | Interacting Domain | MYND domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 23372760, 17560331 | | Comments | N-CoR (NCOR1) recruitment by the MYND domain of AML1/ETO through the PPxLI motif (1033-1037) of N-CoR plays a key role in AML1/ETO's ability to repress proliferation and differentiation of primary bone marrow cells as well as to enhance their self renewal |
Record No : 22 |
| Instance ID | 10549 | | Regular Expression | PPxLI | | Motif Instance | PPPLI | | Bait Uniprot Accession | O75376 | | Bait Uniprot Identifier | NCOR1_HUMAN | | Bait Gene Name | NCOR1 | | Sequence Position | 1033-1037 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; ITC; Fluorescence polarization spectroscopy | | Interaction ID | 20549 | | Interacting Domain | MYND domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 23372760, 17560331 | | Comments | Human DEAF-1 transcription regulation activity is mediated through its interaction with Nuclear receptor corepressor 1 (NCOR1) via its MYND domain that binds to the PPxLI motif (1033-1037) of N-CoR |
Record No : 23 |
| Instance ID | 10550 | | Regular Expression | PPxLI | | Motif Instance | PPPLI | | Bait Uniprot Accession | Q9Y618 | | Bait Uniprot Identifier | NCOR2_HUMAN | | Bait Gene Name | NCOR2 | | Sequence Position | 1113-1117 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; ITC; Fluorescence polarization spectroscopy | | Interaction ID | 20550 | | Interacting Domain | MYND domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 23372760, 17560331 | | Comments | SMRT(NCOR2) recruitment by the MYND domain of AML1/ETO through the PPxLI motif (1113-1117) of SMRT plays a key role in AML1/ETO's ability to repress proliferation and differentiation of primary bone marrow cells as well as to enhance their self renewal |
Record No : 24 |
| Instance ID | 10551 | | Regular Expression | PPxLI | | Motif Instance | PPPLI | | Bait Uniprot Accession | Q9Y618 | | Bait Uniprot Identifier | NCOR2_HUMAN | | Bait Gene Name | NCOR2 | | Sequence Position | 1113-1117 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; ITC; Fluorescence polarization spectroscopy | | Interaction ID | 20551 | | Interacting Domain | MYND domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 23372760, 17560331 | | Comments | Human DEAF-1 transcription regulation activity is mediated through its interaction with Nuclear receptor corepressor 2 (NCOR2/SMRT) via its MYND domain that binds to the PPxLI motif (1113-1117) of SMRT |
Record No : 25 |
| Instance ID | 10557 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | SLSQLLD | | Bait Uniprot Accession | Q9JL19 | | Bait Uniprot Identifier | NCOA6_MOUSE | | Bait Gene Name | Ncoa6 | | Sequence Position | 1494-1500 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 20557 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12724417 | | Comments | The NR box motif (LXXLL) of mouse Nuclear receptor coactivator 6 (Ncoa6)/Activating signal cointegrator 2 (ASC-2) that interacts with Liver X receptor alpha, enabling ASC-2 to act as a physiologically important transcriptional coactivator of LXRalpha in mice |
Record No : 26 |
| Instance ID | 10559 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | LLASLLQ | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 132-138 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 20559 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902 | | Comments | The NR box motif (132-138) of human Nuclear receptor-interacting protein 1 (NRIP1)/ Nuclear factor RIP140 that is necessary for binding the human Estrogen receptor (ESR) |
Record No : 27 |
| Instance ID | 10560 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | HLKTLLK | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 184-190 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 20560 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902 | | Comments | The NR box motif (184-190) of human Nuclear receptor-interacting protein 1 (NRIP1)/ Nuclear factor RIP140 that is necessary for binding the human Estrogen receptor (ESR) |
Record No : 28 |
| Instance ID | 10561 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | YLEGLLM | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 20-26 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 20561 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902 | | Comments | The NR box motif (20-26) of human Nuclear receptor-interacting protein 1 (NRIP1)/ Nuclear factor RIP140 that is necessary for binding the human Estrogen receptor (ESR) |
Record No : 29 |
| Instance ID | 10562 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | QLALLLS | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 265-271 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 20562 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902 | | Comments | The NR box motif (265-271) of human Nuclear receptor-interacting protein 1 (NRIP1)/ Nuclear factor RIP140 that is necessary for binding the human Estrogen receptor (ESR) |
Record No : 30 |
| Instance ID | 10563 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | VLQLLLG | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 712-718 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 20563 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902 | | Comments | The NR box motif (712-718) of human Nuclear receptor-interacting protein 1 (NRIP1)/ Nuclear factor RIP140 that is necessary for binding the human Estrogen receptor (ESR) |
Record No : 31 |
| Instance ID | 10564 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | LLQLLLG | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 500-506 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 20564 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902 | | Comments | The NR box motif (500-506) of human Nuclear receptor-interacting protein 1 (NRIP1)/ Nuclear factor RIP140 that is necessary for binding the human Estrogen receptor (ESR) |
Record No : 32 |
| Instance ID | 10565 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | LLSRLLR | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 818-824 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 20565 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902 | | Comments | The NR box motif (818-824) of human Nuclear receptor-interacting protein 1 (NRIP1)/ Nuclear factor RIP140 that is necessary for binding the human Estrogen receptor (ESR) |
Record No : 33 |
| Instance ID | 10566 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | VLKQLLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 935-941 | | Critical Residues | P2; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20566 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902 | | Comments | The NR box motif (935-941) of human Nuclear receptor-interacting protein 1 (NRIP1)/ Nuclear factor RIP140 that is necessary for binding the human Estrogen receptor (ESR) |
Record No : 34 |
| Instance ID | 10567 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | ILHRLLQ | | Bait Uniprot Accession | Q15596 | | Bait Uniprot Identifier | NCOA2_HUMAN | | Bait Gene Name | NCOA2 | | Sequence Position | 689-695 | | Critical Residues | P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography; Affinity chromatography technology; Mutation analysis | | Interaction ID | 20567 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11937504, 9430642 | | Comments | The NR box motif (689-695) of human Nuclear receptor coactivator 2 (NCOA2)/ Transcriptional intermediary factor 2 (TIF2) that is necessary for binding the human Glucocorticoid receptor (GRL/NR3C1) |
Record No : 35 |
| Instance ID | 10568 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | LLLHLLK | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 379-385 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography; Y2H | | Interaction ID | 20568 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16990259, 9192902 | | Comments | The NR box motif (379-385) of human Nuclear receptor-interacting protein 1 (NRIP1)/ Nuclear factor RIP140 that is necessary for binding the human Estrogen receptor (ESR) |
Record No : 36 |
| Instance ID | 10570 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | LLRYLLD | | Bait Uniprot Accession | Q15596 | | Bait Uniprot Identifier | NCOA2_HUMAN | | Bait Gene Name | NCOA2 | | Sequence Position | 744-750 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20570 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12151000 | | Comments | The NR box motif (744-750) of human Nuclear receptor coactivator 2 (NCOA2)/ Transcriptional intermediary factor 2 (TIF2) that is necessary for binding the human Glucocorticoid receptor (GRL/NR3C1) |
Record No : 37 |
| Instance ID | 10576 | | Regular Expression | [^P]L[^P][^P]LL[^P] | | Motif Instance | KLLQLLT | | Bait Uniprot Accession | Q15596 | | Bait Uniprot Identifier | NCOA2_HUMAN | | Bait Gene Name | NCOA2 | | Sequence Position | 640-646 | | Critical Residues | P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Affinity chromatography technology; Mutation analysis | | Interaction ID | 20576 | | Interacting Domain | Ligand-binding domain of nuclear hormone receptor | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9430642 | | Comments | The NR box motif (640-646) of human Nuclear receptor coactivator 2 (NCOA2)/ Transcriptional intermediary factor 2 (TIF2) that is necessary for binding the human Glucocorticoid receptor (GRL/NR3C1) |
Record No : 38 |
| Instance ID | 10593 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | SKLNPNAPLFIPA | | Bait Uniprot Accession | Q6ELF8 | | Bait Uniprot Identifier | Q6ELF8_CUCSA | | Bait Gene Name | Not Available | | Sequence Position | 10-22 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20593 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15159636 | | Comments | The PABP-interacting motif 2 (PAM2) in cucumber Poly(A)-binding protein C-terminal interacting protein 243 (PCI243) that mediates binding to the MLLE domain of cucumber Poly(A)-binding protein |
Record No : 39 |
| Instance ID | 10597 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | FKFNTDAAEFIPQ | | Bait Uniprot Accession | Q12986 | | Bait Uniprot Identifier | NFX1_HUMAN | | Bait Gene Name | NFX1 | | Sequence Position | 11-23 | | Critical Residues | P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down; Co-IP; Mass spectrometry; Affinity chromatography technology | | Interaction ID | 20597 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17267499 | | Comments | Human cytoplasmic Polyadenylate-binding protein 1 (PABP1/PABPC1/PABPC2) interacts with NFX1-123, a splice variant of Transcriptional repressor NFX1, through its N-terminal PAM2 motif, and this interaction is critical to hTERT regulation in HPV16 E6-expressing epithelial cells |
Record No : 40 |
| Instance ID | 10598 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | FKFNTDAAEFIPQ | | Bait Uniprot Accession | Q12986 | | Bait Uniprot Identifier | NFX1_HUMAN | | Bait Gene Name | NFX1 | | Sequence Position | 11-23 | | Critical Residues | P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down; Co-IP; Mass spectrometry; Affinity chromatography technology | | Interaction ID | 20598 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17267499 | | Comments | Human cytoplasmic Polyadenylate-binding protein 4 (PABP4/PABPC4) interacts with NFX1-123, a splice variant of Transcriptional repressor NFX1, through its N-terminal PAM2 motif, and this interaction is critical to hTERT regulation in HPV16 E6-expressing epithelial cells |
Record No : 41 |
| Instance ID | 10609 | | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | | Motif Instance | SMLNPNAPLFVPM | | Bait Uniprot Accession | Q6ELF9 | | Bait Uniprot Identifier | Q6ELF9_CUCSA | | Bait Gene Name | Not Available | | Sequence Position | 14-26 | | Critical Residues | P3; P10 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20609 | | Interacting Domain | MLLE domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15159636 | | Comments | The PABP-interacting motif 2 (PAM2) in cucumber Poly(A)-binding protein C-terminal interacting protein 6 (PCI6) that mediates binding of proteins to the MLLE domain of cucumber Poly(A)-binding protein |
Record No : 42 |
| Instance ID | 10646 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | SEETQL | | Bait Uniprot Accession | Q7TFX0 | | Bait Uniprot Identifier | Q7TFX0_RHCM6 | | Bait Gene Name | Not Available | | Sequence Position | 141-146 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Display technology | | Interaction ID | 20646 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18828675 | | Comments | C-terminal class 1 PDZ-binding motif in the Rh11 protein of Rhesus cytomegalovirus that binds to the human Scribble (SCRIB) PDZ domain |
Record No : 43 |
| Instance ID | 10682 | | Regular Expression | xxx[VLIFY]x[ACVILF]$ | | Motif Instance | DKEYYV | | Bait Uniprot Accession | Q07310 | | Bait Uniprot Identifier | NRX3A_RAT | | Bait Gene Name | Nrxn3 | | Sequence Position | 1573-1578 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Y2H | | Interaction ID | 20682 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9707552 | | Comments | The C-terminal class 2 PDZ-binding motif of rat Neurexin III-alpha (Nrxn3) that binds to the PDZ domain of rat Af6 (Mllt4) |
Record No : 44 |
| Instance ID | 10685 | | Regular Expression | xxx[VLIFY]x[ACVILF]$ | | Motif Instance | DREYYV | | Bait Uniprot Accession | Q9Y4C0 | | Bait Uniprot Identifier | NRX3A_HUMAN | | Bait Gene Name | NRXN3 | | Sequence Position | 1638-1643 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Y2H | | Interaction ID | 20685 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9707552 | | Comments | The C-terminal class 2 PDZ-binding motif of human Neurexin III-alpha (NRXN3) that binds to the PDZ domain of rat Af6 (Mllt4) |
Record No : 45 |
| Instance ID | 10688 | | Regular Expression | [DEN][DEN]x{2,3}[ILMVA][DEN][DEN]L | | Motif Instance | EESLADDL | | Bait Uniprot Accession | O60934 | | Bait Uniprot Identifier | NBN_HUMAN | | Bait Gene Name | NBN | | Sequence Position | 736-743 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Co-IP; Pull down | | Interaction ID | 20688 | | Interacting Domain | HEAT repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17507690, 15964794, 15758953 | | Comments | The extreme C terminus of human Nibrin/NBS1(NBN) contains an evolutionarily conserved sequence motif that is critical for binding to and activation of Serine-protein kinase ATM in the cellular response to DNA damage induced by ionizing radiation (IR) |
Record No : 46 |
| Instance ID | 10690 | | Regular Expression | [DEN][DEN]x{2,3}[ILMVA][DEN][DEN]L | | Motif Instance | EESLAEDL | | Bait Uniprot Accession | Q6XV80 | | Bait Uniprot Identifier | Q6XV80_XENLA | | Bait Gene Name | nbn | | Sequence Position | 744-751 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Co-IP | | Interaction ID | 20690 | | Interacting Domain | HEAT repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15964794 | | Comments | The C terminus of Xenopus Nibrin (nbn/Nbs1) recruits ATM to damaged DNA and is essential for ATM activation |
Record No : 47 |
| Instance ID | 10709 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | KKKVHFS | | Bait Uniprot Accession | P51955 | | Bait Uniprot Identifier | NEK2_HUMAN | | Bait Gene Name | NEK2 | | Sequence Position | 381-387 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Co-IP; Y2H; Co-IP; Mutation analysis | | Interaction ID | 20709 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10880350 | | Comments | The RVXF motif in the C-terminal region of the cell cycle-regulated protein serine/threonine NIMA-related kinase 2 (NEK2) that mediates binding to the catalytic subunit of protein phosphatase 1 (PPP1CA) |
Record No : 48 |
| Instance ID | 10714 | | Regular Expression | xP[^P]I[^P][IV][^P] | | Motif Instance | SPRIEIT | | Bait Uniprot Accession | O95644 | | Bait Uniprot Identifier | NFAC1_HUMAN | | Bait Gene Name | NFATC1 | | Sequence Position | 117-123 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR | | Interaction ID | 20714 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17502104 | | Comments | The calcineurin docking motif on the human transcription factor NFAT (NFATC1) that mediates the interaction between human Calmodulin-dependent calcineurin A subunit alpha isoform (PPP3CA) and NFAT |
Record No : 49 |
| Instance ID | 10732 | | Regular Expression | xP[TS]APx | | Motif Instance | SPSAPQ | | Bait Uniprot Accession | P27588 | | Bait Uniprot Identifier | NCAP_MABVM | | Bait Gene Name | NP | | Sequence Position | 602-607 | | Critical Residues | P2; P3; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Co-IP; Mutation analysis | | Interaction ID | 20732 | | Interacting Domain | UEV domain | | Disease Association(s) | Marburg virus infection | | Inhibitor(s) | Unknown | | Reference(s) | 20504928 | | Comments | The UEV Domain binding P[TS]AP motif in Nucleocapsid protein of Marburg virus that mediates binding to the UEV domain of human ESCRT-I complex subunit TSG101 |
Record No : 50 |
| Instance ID | 10755 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | GFSNMSFE | | Bait Uniprot Accession | Q9U485 | | Bait Uniprot Identifier | Q9U485_DROME | | Bait Gene Name | Nak | | Sequence Position | 1439-1446 | | Critical Residues | P2; P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Alanine scanning | | Interaction ID | 20755 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10747019 | | Comments | High-affinity binding of the Drosophila Numb phosphotyrosine-binding (PTB) domain to the NPXY motif of Drosophila Numb-associated kinase (Nak) |
Record No : 51 |
| Instance ID | 10757 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | LLSNPTY | | Bait Uniprot Accession | P03077 | | Bait Uniprot Identifier | MT_POVMA | | Bait Gene Name | Not Available | | Sequence Position | 244-250 | | Critical Residues | P2; P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | NMR; Alanine scanning | | Interaction ID | 20757 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7543098 | | Comments | Phosphorylation of Y250 in the PTB-binding NPxY motif of Middle T antigen of Murine polyomavirus induces binding to the PTB domain of human SHC-transforming protein 1 (SHC1) |
Record No : 52 |
| Instance ID | 10758 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | IIENPQY | | Bait Uniprot Accession | P04629 | | Bait Uniprot Identifier | NTRK1_HUMAN | | Bait Gene Name | NTRK1 | | Sequence Position | 490-496 | | Critical Residues | P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | ITC; Mutation analysis; NMR | | Interaction ID | 20758 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8524391 | | Comments | The phosphotyrosine binding (PTB) domain of human SHC-transforming protein 1 (SHC1) binds to tyrosine-phosphorylated NPxY motif of human Neurotrophic tyrosine kinase receptor type 1 (NTRK1) |
Record No : 53 |
| Instance ID | 10793 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LPCAE | | Bait Uniprot Accession | P13889 | | Bait Uniprot Identifier | POLN_RUBVT | | Bait Gene Name | Not Available | | Sequence Position | 1902-1906 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 20793 | | Interacting Domain | B domain | | Disease Association(s) | Rubella | | Inhibitor(s) | Unknown | | Reference(s) | 10073691 | | Comments | The Rb-binding LxCxE motif in the Rubella virus (RV)-encoded protein NSP90 that interacts with the human retinoblastoma protein (RB) and is required for efficient RV replication |
Record No : 54 |
| Instance ID | 10799 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LYCDE | | Bait Uniprot Accession | Q9WKM8 | | Bait Uniprot Identifier | Q9WKM8_BBTV | | Bait Gene Name | Not Available | | Sequence Position | 111-115 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20799 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10640570 | | Comments | The Rb-binding LxCxE motif in the Banana bunchy top virus (BBTV) DNA-5 protein that mediates binding to the human retinoblastoma protein (RB) |
Record No : 55 |
| Instance ID | 10805 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LTCHE | | Bait Uniprot Accession | P03255 | | Bait Uniprot Identifier | E1A_ADE05 | | Bait Gene Name | Not Available | | Sequence Position | 122-126 | | Critical Residues | P1; P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Competition binding | | Interaction ID | 20805 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8084002, 1534854 | | Comments | The Rb-binding LxCxE motif in the Human adenovirus Early E1A 32 kDa protein that mediates binding to the human retinoblastoma protein (RB) |
Record No : 56 |
| Instance ID | 10806 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LFCSE | | Bait Uniprot Accession | P03070 | | Bait Uniprot Identifier | LT_SV40 | | Bait Gene Name | Not Available | | Sequence Position | 103-107 | | Critical Residues | P1; P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis; X-ray crystallography | | Interaction ID | 20806 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 2839300, 11226179 | | Comments | The Rb-binding LxCxE motif in the SV40 large T antigen that mediates binding to the human retinoblastoma protein (RB) |
Record No : 57 |
| Instance ID | 10809 | | Regular Expression | xx[LIMV]xx[LM][FY]Dx | | Motif Instance | PTLHELYDL | | Bait Uniprot Accession | P03255 | | Bait Uniprot Identifier | E1A_ADE05 | | Bait Gene Name | Not Available | | Sequence Position | 41-49 | | Critical Residues | P3; P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; ITC; Pull down(GST tag); X-ray crystallography | | Interaction ID | 20809 | | Interacting Domain | Rb pocket AB groove | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1534854, 17974914 | | Comments | The LxxLFD retinoblastoma (RB)-binding sequence in the amino terminus of Human adenovirus Early E1A 32 kDa protein that mediates binding to the human retinoblastoma protein (RB) |
Record No : 58 |
| Instance ID | 10812 | | Regular Expression | RGD | | Motif Instance | RGD | | Bait Uniprot Accession | P21404 | | Bait Uniprot Identifier | POLG_CXA9 | | Bait Gene Name | Not Available | | Sequence Position | 858-860 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Solid phase assay; Fluorescence-activated cell sorting | | Interaction ID | 20812 | | Interacting Domain | N-terminal Integrin beta subunit | | Disease Association(s) | Coxsackie virus infection | | Inhibitor(s) | Unknown | | Reference(s) | 15194773 | | Comments | The Integrin binding RGD motif in VP1 capsid protein of Coxsackievirus A9 (CAV9) that mediates binding to the human Integrin beta-6 (ITGB6) |
Record No : 59 |
| Instance ID | 10813 | | Regular Expression | RGD | | Motif Instance | RGD | | Bait Uniprot Accession | Q66578 | | Bait Uniprot Identifier | POLG_HPE1H | | Bait Gene Name | Not Available | | Sequence Position | 764-766 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Peptide blocking assay | | Interaction ID | 20813 | | Interacting Domain | N-terminal Integrin beta subunit | | Disease Association(s) | Human parechovirus (HPEV) infection | | Inhibitor(s) | Unknown | | Reference(s) | 20554778 | | Comments | The C-terminal RGD motif in the Human parechovirus (HPEV) capsid protein VP1 that mediates binding to the human Integrin beta-6 (ITGB6) |
Record No : 60 |
| Instance ID | 10814 | | Regular Expression | RGD | | Motif Instance | RGD | | Bait Uniprot Accession | P03305 | | Bait Uniprot Identifier | POLG_FMDVO | | Bait Gene Name | Not Available | | Sequence Position | 869-871 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding | | Interaction ID | 20814 | | Interacting Domain | N-terminal Integrin beta subunit | | Disease Association(s) | Hand-foot-and-mouth disease (HFMD) | | Inhibitor(s) | Unknown | | Reference(s) | 7533862 | | Comments | The Integrin binding RGD motif in VP1 capsid protein of foot-and-mouth disease virus (FMDV) that mediates binding to the Human Integrin beta-3 (ITGB3) |
Record No : 61 |
| Instance ID | 10825 | | Regular Expression | [LIVMP]x{0,2}(T)PxxE | | Motif Instance | PFLTPSPE | | Bait Uniprot Accession | P46531 | | Bait Uniprot Identifier | NOTC1_HUMAN | | Bait Gene Name | NOTCH1 | | Sequence Position | 2508-2515 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 20825 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11585921, 11461910 | | Comments | The phospho-dependent degron in Human Neurogenic locus notch homolog protein 1 (NOTCH1) that binds the F-box/WD40 repeat protein FBW7 (also called FBXW7, hCdc4 or SEL-10), which leads to an increase in Notch signaling |
Record No : 62 |
| Instance ID | 10826 | | Regular Expression | [LIVMP]x{0,2}(T)PxxE | | Motif Instance | PPTPPPE | | Bait Uniprot Accession | P03070 | | Bait Uniprot Identifier | LT_SV40 | | Bait Gene Name | Not Available | | Sequence Position | 699-705 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Thr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Classical fluorescence spectroscopy; Mutation analysis | | Interaction ID | 20826 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15611062 | | Comments | The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with the F box protein FBW7/FBXW7/hCdc4 |
Record No : 63 |
| Instance ID | 10830 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGLGS | | Bait Uniprot Accession | Q15653 | | Bait Uniprot Identifier | IKBB_HUMAN | | Bait Gene Name | NFKBIB | | Sequence Position | 18-23 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Radiolabel; Co-IP | | Interaction ID | 20830 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10497169 | | Comments | The DSGxxS phospho-dependent degron in human NF-kappa-B inhibitor beta (NFKBIB/IKBB) that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC) of the SCF-betaTrCP1 complex leading to ubiquitination and degradation of IKBB |
Record No : 64 |
| Instance ID | 10831 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGIES | | Bait Uniprot Accession | O00221 | | Bait Uniprot Identifier | IKBE_HUMAN | | Bait Gene Name | NFKBIE | | Sequence Position | 156-161 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Radiolabel; Co-IP | | Interaction ID | 20831 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10497169 | | Comments | The DSGxxS phospho-dependent degron in human NF-kappa-B inhibitor epsilon (NFKBIE/IKBE) that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC) of the SCF-betaTrCP1 complex leading to ubiquitination and degradation of IKBE |
Record No : 65 |
| Instance ID | 10833 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGVETS | | Bait Uniprot Accession | P19838 | | Bait Uniprot Identifier | NFKB1_HUMAN | | Bait Gene Name | NFKB1 | | Sequence Position | 926-932 | | Critical Residues | P2; P7 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P7 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Peptide binding to perpetrator; Protein kinase assay | | Interaction ID | 20833 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12482991 | | Comments | The DSGxxS phospho-dependent degron present in human Nuclear factor NF-kappa-B p105 subunit (NFKB1) that binds to the F-box/WD repeat-containing protein beta-TrCP (BTRC) for beta-TrCP-mediated proteolysis of NF-kappaB1 p105 |
Record No : 66 |
| Instance ID | 10834 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGLDS | | Bait Uniprot Accession | P25963 | | Bait Uniprot Identifier | IKBA_HUMAN | | Bait Gene Name | NFKBIA | | Sequence Position | 31-36 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Radiolabel; Mass spectrometry; Protein kinase assay; Peptide binding to perpetrator; Co-IP | | Interaction ID | 20834 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10497169, 10230406, 9990852 | | Comments | The DSGxxS phospho-dependent degron in human NF-kappa-B inhibitor alpha (NFKBIA/IKBA) that binds to the F-box/WD repeat-containing protein beta-TrCP (BTRC), which recruits IKBA to the SCF ubiquitin ligase complex leading to its ubiquitination and degradation |
Record No : 67 |
| Instance ID | 10859 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YEEI | | Bait Uniprot Accession | P03079 | | Bait Uniprot Identifier | MT_POVHA | | Bait Gene Name | Not Available | | Sequence Position | 324-327 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20859 | | Interacting Domain | SH2 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 8985339 | | Comments | Middle-T antigen of hamster polyomavirus (HamT) associates with the SH2 domain of Proto-oncogene c-Fyn through phosphorylated Tyr-324, which is essential for the oncogenicity of HamT |
Record No : 68 |
| Instance ID | 10861 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YDEV | | Bait Uniprot Accession | O60500 | | Bait Uniprot Identifier | NPHN_HUMAN | | Bait Gene Name | NPHS1 | | Sequence Position | 1176-1179 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20861 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16525419 | | Comments | The cytoplasmic tail of human Renal glomerulus-specific cell adhesion receptor Nephrin selectively binds the mouse Nck adaptor protein, which in turn control the podocyte cytoskeleton |
Record No : 69 |
| Instance ID | 10866 | | Regular Expression | (Y)xxQ | | Motif Instance | YLPQ | | Bait Uniprot Accession | P25049 | | Bait Uniprot Identifier | TIP_SHV24 | | Bait Gene Name | Not Available | | Sequence Position | 72-75 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20866 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10747948 | | Comments | The Tip protein from Herpesvirus saimiri is phosphorylated at Tyr-72 creating a consensus binding site for the DNA binding human transcription factor STAT3 for induction of STAT-dependent transcription during normal T cell activation events |
Record No : 70 |
| Instance ID | 10884 | | Regular Expression | PxxPx[KR] | | Motif Instance | PQVPLR | | Bait Uniprot Accession | P03406 | | Bait Uniprot Identifier | NEF_HV1BR | | Bait Gene Name | nef | | Sequence Position | 72-77 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Alanine scanning; Western blot; X-ray crystallography | | Interaction ID | 20884 | | Interacting Domain | SH3 domain | | Disease Association(s) | Human immunodeficiency virus (HIV) infection | | Inhibitor(s) | Unknown | | Reference(s) | 7859737, 8681387 | | Comments | Proline-rich (PxxP) motif in HIV-1 Nef that binds to the SH3 domain of human Tyrosine-protein kinase Fyn and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4 |
Record No : 71 |
| Instance ID | 10891 | | Regular Expression | PxxPx[KR] | | Motif Instance | PIPPPR | | Bait Uniprot Accession | P26662 | | Bait Uniprot Identifier | POLG_HCVJA | | Bait Gene Name | Not Available | | Sequence Position | 2323-2328 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Mutation analysis; Sequence based prediction; Confocal microscopy; Pull down; Y2H; Co-IP | | Interaction ID | 20891 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19656877, 16530520 | | Comments | The SH3 binding motif of hepatitis C virus (HCV) nonstructural protein 5A (NS5A) interacts with Human BIN1, a tumor suppressor with pro-apoptotic properties, and is important for apoptosis and infectivity as well as may contribute to the pathogenesis of hepatocellular carcinoma |
Record No : 72 |
| Instance ID | 10892 | | Regular Expression | PxxPx[KR] | | Motif Instance | PAVPPR | | Bait Uniprot Accession | P14598 | | Bait Uniprot Identifier | NCF1_HUMAN | | Bait Gene Name | NCF1 | | Sequence Position | 363-368 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography; Pull down | | Interaction ID | 20892 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15657040, 9121467 | | Comments | The polyproline motif in human Neutrophil cytosol factor 1 (NCF1) or p47-phox that can interact with the SH3 domain of human Neutrophil cytosol factor 4 (NCF4) or p40-phox |
Record No : 73 |
| Instance ID | 10904 | | Regular Expression | xxx[PV]xxP | | Motif Instance | PTLPPRP | | Bait Uniprot Accession | P25049 | | Bait Uniprot Identifier | TIP_SHV24 | | Bait Gene Name | Not Available | | Sequence Position | 135-141 | | Critical Residues | P1; P4; P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Mutation analysis; Co-IP; Pull down | | Interaction ID | 20904 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11040125 | | Comments | A proline-rich region in Tip protein of Herpesvirus saimiri strain 484C binds to the SH3 domain and activates the human Proto-oncogene LCK |
Record No : 74 |
| Instance ID | 10905 | | Regular Expression | xxx[PV]xxP | | Motif Instance | SPLPSFP | | Bait Uniprot Accession | P03495 | | Bait Uniprot Identifier | NS1_I72A2 | | Bait Gene Name | NS | | Sequence Position | 161-167 | | Critical Residues | P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Co-IP; Western blot; Pull down; Mutation analysis | | Interaction ID | 20905 | | Interacting Domain | SH3 domain | | Disease Association(s) | Influenza | | Inhibitor(s) | Unknown | | Reference(s) | 17881440 | | Comments | SH3 binding motif 1 in influenza A virus NS1 protein mediate binding to the p85 subunit of Human Phosphatidylinositol 3-kinase (PI3K) and is essential for PI3K/Akt signaling pathway activation |
Record No : 75 |
| Instance ID | 11000 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | PRTQPDGT | | Bait Uniprot Accession | Q14980 | | Bait Uniprot Identifier | NUMA1_HUMAN | | Bait Gene Name | NUMA1 | | Sequence Position | 1742-1749 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Affinity chromatography technology; X-ray crystallography | | Interaction ID | 21000 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12080061, 22153077 | | Comments | The N-terminal region of ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif in human Nuclear mitotic apparatus protein 1 (NUMA1) |
Record No : 76 |
| Instance ID | 11072 | | Regular Expression | xxx([ST])Px | | Motif Instance | EAASPR | | Bait Uniprot Accession | Q80Z64 | | Bait Uniprot Identifier | NANOG_MOUSE | | Bait Gene Name | Nanog | | Sequence Position | 49-54 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Alanine scanning | | Interaction ID | 21072 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20622153 | | Comments | Phosphorylation of Ser-52 promotes the interaction between the mouse Homeobox protein Nanog and the mouse Peptidyl-prolyl cis-trans isomerase Pin1, leading to Nanog stabilization by suppressing its ubiquitination |
Record No : 77 |
| Instance ID | 11073 | | Regular Expression | xxx([ST])Px | | Motif Instance | LQGSPD | | Bait Uniprot Accession | Q80Z64 | | Bait Uniprot Identifier | NANOG_MOUSE | | Bait Gene Name | Nanog | | Sequence Position | 62-67 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Alanine scanning | | Interaction ID | 21073 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20622153 | | Comments | Phosphorylation of Ser-65 promotes the interaction between the mouse Homeobox protein Nanog and the mouse Peptidyl-prolyl cis-trans isomerase Pin1, leading to Nanog stabilization by suppressing its ubiquitination |
Record No : 78 |
| Instance ID | 11089 | | Regular Expression | xxx([ST])Px | | Motif Instance | SAPSPS | | Bait Uniprot Accession | P22736 | | Bait Uniprot Identifier | NR4A1_HUMAN | | Bait Gene Name | NR4A1 | | Sequence Position | 137-142 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Pull down(GST tag) | | Interaction ID | 21089 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 22002310 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 stabilizes and activates human Orphan nuclear receptor TR3 (NR4A1) through its Ser-140-Pro motif to promote mitogenesis and tumor growth |
Record No : 79 |
| Instance ID | 11091 | | Regular Expression | xxx([ST])Px | | Motif Instance | LGGTPT | | Bait Uniprot Accession | P46531 | | Bait Uniprot Identifier | NOTC1_HUMAN | | Bait Gene Name | NOTCH1 | | Sequence Position | 2129-2134 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Pull down; Co-IP; Alanine scanning | | Interaction ID | 21091 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19151708 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Thr-2132-Pro motif of human NOTCH1, thereby enhancing NOTCH1 transcriptional and tumorigenic activity |
Record No : 80 |
| Instance ID | 11093 | | Regular Expression | xxx([ST])Px | | Motif Instance | PPGTPA | | Bait Uniprot Accession | Q99K48 | | Bait Uniprot Identifier | NONO_MOUSE | | Bait Gene Name | Nono | | Sequence Position | 409-414 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Solid phase assay | | Interaction ID | 21093 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15701524 | | Comments | The Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the phosphorylated Thr-412-Pro motif of mouse NonO protein |
Record No : 81 |
| Instance ID | 11094 | | Regular Expression | xxx([ST])Px | | Motif Instance | LGLTPP | | Bait Uniprot Accession | Q99K48 | | Bait Uniprot Identifier | NONO_MOUSE | | Bait Gene Name | Nono | | Sequence Position | 427-432 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Solid phase assay | | Interaction ID | 21094 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15701524 | | Comments | The Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the phosphorylated Thr-430-Pro motif of mouse NonO protein |
Record No : 82 |
| Instance ID | 11095 | | Regular Expression | xxx([ST])Px | | Motif Instance | IGGTPP | | Bait Uniprot Accession | Q99K48 | | Bait Uniprot Identifier | NONO_MOUSE | | Bait Gene Name | Nono | | Sequence Position | 449-454 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Solid phase assay | | Interaction ID | 21095 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15701524 | | Comments | The Mouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the phosphorylated Thr-452-Pro motif of mouse NonO protein |
Record No : 83 |
| Instance ID | 11123 | | Regular Expression | xxx([ST])Px | | Motif Instance | THGTPA | | Bait Uniprot Accession | Q9Y618 | | Bait Uniprot Identifier | NCOR2_HUMAN | | Bait Gene Name | NCOR2 | | Sequence Position | 1238-1243 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down; Y2H; Co-IP | | Interaction ID | 21123 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18838553 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 interacts with the phosphorylated Thr-1241-Pro motif of human Nuclear receptor corepressor 2 (NCOR2)/SMRT |
Record No : 84 |
| Instance ID | 11124 | | Regular Expression | xxx([ST])Px | | Motif Instance | LRHTPE | | Bait Uniprot Accession | Q9Y618 | | Bait Uniprot Identifier | NCOR2_HUMAN | | Bait Gene Name | NCOR2 | | Sequence Position | 1441-1446 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down; Y2H; Co-IP | | Interaction ID | 21124 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18838553 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 interacts with the phosphorylated Thr-1444-Pro motif of human Nuclear receptor corepressor 2 (NCOR2)/SMRT |
Record No : 85 |
| Instance ID | 11125 | | Regular Expression | xxx([ST])Px | | Motif Instance | PYASPP | | Bait Uniprot Accession | P33242 | | Bait Uniprot Identifier | STF1_MOUSE | | Bait Gene Name | Nr5a1 | | Sequence Position | 200-205 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 21125 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19995909 | | Comments | Mouse Peptidyl-prolyl cis-trans isomerase Pin1 facilitates the Ser-203 phosphorylation-dependent ubiquitination ubiquitination of mouse Steroidogenic factor 1 (Nr5a1) to regulate gonadotropin beta-subunit gene transcription |
Record No : 86 |
| Instance ID | 11133 | | Regular Expression | xxx([ST])Px | | Motif Instance | GPQSPG | | Bait Uniprot Accession | P14598 | | Bait Uniprot Identifier | NCF1_HUMAN | | Bait Gene Name | NCF1 | | Sequence Position | 342-347 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Far Western blotting; Pull down | | Interaction ID | 21133 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20956805 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to human Neutrophil cytosol factor 1 (NCF1)/p47phox on phosphorylated Ser345, thereby inducing conformational changes that facilitate p47phox phosphorylation on other sites by protein kinase C |
Record No : 87 |
| Instance ID | 11134 | | Regular Expression | xxx([ST])Px | | Motif Instance | AELSPA | | Bait Uniprot Accession | P22736 | | Bait Uniprot Identifier | NR4A1_HUMAN | | Bait Gene Name | NR4A1 | | Sequence Position | 428-433 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Alanine scanning | | Interaction ID | 21134 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 22002310 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 stabilizes and activates human Orphan nuclear receptor TR3 (NR4A1) through its Ser-431-Pro motif to promote mitogenesis and tumor growth |
Record No : 88 |
| Instance ID | 11135 | | Regular Expression | xxx([ST])Px | | Motif Instance | SATSPA | | Bait Uniprot Accession | P22736 | | Bait Uniprot Identifier | NR4A1_HUMAN | | Bait Gene Name | NR4A1 | | Sequence Position | 92-97 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Alanine scanning | | Interaction ID | 21135 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 22002310 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 stabilizes and activates human Orphan nuclear receptor TR3 (NR4A1) through its Ser-95-Pro motif to promote mitogenesis and tumor growth |
Record No : 89 |
| Instance ID | 11141 | | Regular Expression | xxx([ST])Px | | Motif Instance | YYMSPE | | Bait Uniprot Accession | Q9HC98 | | Bait Uniprot Identifier | NEK6_HUMAN | | Bait Gene Name | NEK6 | | Sequence Position | 212-217 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down(GST tag) | | Interaction ID | 21141 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16476580 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the Ser-215-Pro motif of human Serine/threonine-protein kinase NEK6 |
Record No : 90 |
| Instance ID | 11142 | | Regular Expression | xxx([ST])Px | | Motif Instance | ALQSPF | | Bait Uniprot Accession | Q9HC98 | | Bait Uniprot Identifier | NEK6_HUMAN | | Bait Gene Name | NEK6 | | Sequence Position | 242-247 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down(GST tag) | | Interaction ID | 21142 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16476580 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the Ser-245-Pro motif of human Serine/threonine-protein kinase NEK6 |
Record No : 91 |
| Instance ID | 11143 | | Regular Expression | xxx([ST])Px | | Motif Instance | LVRSPQ | | Bait Uniprot Accession | P46531 | | Bait Uniprot Identifier | NOTC1_HUMAN | | Bait Gene Name | NOTCH1 | | Sequence Position | 2118-2123 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Far Western blotting; Western blot; Co-IP; Pull down(GST tag); Alanine scanning | | Interaction ID | 21143 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19151708 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds directly to human NOTCH1 at the Ser-2121-Pro motif and regulates its activity, cooperating with NOTCH1 in tumorigenesis |
Record No : 92 |
| Instance ID | 11145 | | Regular Expression | xxx([ST])Px | | Motif Instance | PTLSPP | | Bait Uniprot Accession | P46531 | | Bait Uniprot Identifier | NOTC1_HUMAN | | Bait Gene Name | NOTCH1 | | Sequence Position | 2133-2138 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Far Western blotting; Western blot; Co-IP; Pull down(GST tag); Alanine scanning | | Interaction ID | 21145 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19151708 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds directly to human NOTCH1 at the Ser-2136-Pro motif and regulates its activity, cooperating with NOTCH1 in tumorigenesis |
Record No : 93 |
| Instance ID | 11157 | | Regular Expression | xxx([ST])Px | | Motif Instance | SPSTPS | | Bait Uniprot Accession | P22736 | | Bait Uniprot Identifier | NR4A1_HUMAN | | Bait Gene Name | NR4A1 | | Sequence Position | 140-145 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Alanine scanning; Pull down(GST tag) | | Interaction ID | 21157 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 22002310 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 stabilizes and activates human Orphan nuclear receptor TR3 (NR4A1) through its phosphorylated Thr-143-Pro motif to promote mitogenesis and tumor growth |
Record No : 94 |
| Instance ID | 11178 | | Regular Expression | [EN][FYLW][NSQ]xEE[ILMVF][^P][LIVMFA] | | Motif Instance | NFSFEELRF | | Bait Uniprot Accession | Q02630 | | Bait Uniprot Identifier | NU116_YEAST | | Bait Gene Name | NUP116 | | Sequence Position | 150-158 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 21178 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9463388 | | Comments | The Gle2-binding-sequence (GLEBS) motif found within yeast Nucleoporin Nup116p is sufficient and necessary to anchor yeast Nucleoporin Gle2p at the nuclear pores |
Record No : 95 |
| Instance ID | 11181 | | Regular Expression | L[^P]{2,2}[HI]I[^P]{2,2}[IAV][IL] | | Motif Instance | LEDIIRKAL | | Bait Uniprot Accession | O75376 | | Bait Uniprot Identifier | NCOR1_HUMAN | | Bait Gene Name | NCOR1 | | Sequence Position | 2263-2271 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 21181 | | Interacting Domain | AF-2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Mifepristone | | Reference(s) | 19913032 | | Comments | The corepressor nuclear receptor (CORNR) box found in the human Nuclear receptor corepressor 1 (NCOR1) that confers binding to the AF-2 domain of human Retinoic acid receptor alpha (RARA) |
Record No : 96 |
| Instance ID | 11182 | | Regular Expression | L[^P]{2,2}[HI]I[^P]{2,2}[IAV][IL] | | Motif Instance | LADHICQII | | Bait Uniprot Accession | O75376 | | Bait Uniprot Identifier | NCOR1_HUMAN | | Bait Gene Name | NCOR1 | | Sequence Position | 2051-2059 | | Critical Residues | P5; P8; P9 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography; Mutation analysis | | Interaction ID | 21182 | | Interacting Domain | AF-2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20581824 | | Comments | The corepressor nuclear receptor (CORNR) box found in the human Nuclear receptor corepressor 1 (NCOR1) that confers binding to the AF-2 domain of human Rev-erbA-alpha (NR1D1) |
Record No : 97 |
| Instance ID | 11183 | | Regular Expression | L[^P]{2,2}[HI]I[^P]{2,2}[IAV][IL] | | Motif Instance | LAQHISEVI | | Bait Uniprot Accession | Q9Y618 | | Bait Uniprot Identifier | NCOR2_HUMAN | | Bait Gene Name | NCOR2 | | Sequence Position | 2143-2151 | | Critical Residues | P1; P5; P9 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Pull down(GST tag); Mammalian two-hybrid assay; Alanine scanning | | Interaction ID | 21183 | | Interacting Domain | AF-2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10617569 | | Comments | The corepressor nuclear receptor (CORNR) box (2143-2151) found in the human Nuclear receptor corepressor 2 (NCOR2)/ SMRT that confers binding to the AF-2 domain of human Peroxisome proliferator-activated receptor alpha (PPARA) |
Record No : 98 |
| Instance ID | 11184 | | Regular Expression | L[^P]{2,2}[HI]I[^P]{2,2}[IAV][IL] | | Motif Instance | LEAIIRKAL | | Bait Uniprot Accession | Q9Y618 | | Bait Uniprot Identifier | NCOR2_HUMAN | | Bait Gene Name | NCOR2 | | Sequence Position | 2350-2358 | | Critical Residues | P1; P5; P9 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography; Mutation analysis | | Interaction ID | 21184 | | Interacting Domain | AF-2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11845213 | | Comments | The corepressor nuclear receptor (CORNR) box (2350-2358) found in the human Nuclear receptor corepressor 2 (NCOR2)/ SMRT that confers binding to the AF-2 domain of human Peroxisome proliferator-activated receptor alpha (PPARA) |
Record No : 99 |
| Instance ID | 11207 | | Regular Expression | WxP | | Motif Instance | WFP | | Bait Uniprot Accession | Q01705 | | Bait Uniprot Identifier | NOTC1_MOUSE | | Bait Gene Name | Notch1 | | Sequence Position | 1758-1760 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; MASLS; Cross-linking experiments; Comigration in gel electrophoresis | | Interaction ID | 21207 | | Interacting Domain | Beta-trefoil domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17070841, 20028974 | | Comments | The conserved WFP sequence motif within the RAM region (the approximately 140 residue polypeptide segment N-terminal to the ANK domain) of mouse Notch1 protein that mediates binding to the beta trefoil domain (or BTD) of human CSL (RBPJ) |
Record No : 100 |
| Instance ID | 11208 | | Regular Expression | WxP | | Motif Instance | WFP | | Bait Uniprot Accession | Q01705 | | Bait Uniprot Identifier | NOTC1_MOUSE | | Bait Gene Name | Notch1 | | Sequence Position | 1758-1760 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21208 | | Interacting Domain | Beta-trefoil domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 8749394, 20028974 | | Comments | The conserved WFP sequence motif within the RAM region of mouse Notch1 protein that mediates binding to the beta trefoil domain (or BTD) of mouse RBP-J kappa |
Record No : 101 |
| Instance ID | 11209 | | Regular Expression | WxP | | Motif Instance | WFP | | Bait Uniprot Accession | Q61982 | | Bait Uniprot Identifier | NOTC3_MOUSE | | Bait Gene Name | Notch3 | | Sequence Position | 1676-1678 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; ITC | | Interaction ID | 21209 | | Interacting Domain | Beta-trefoil domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 8898100, 20028974 | | Comments | The conserved WFP sequence motif within the RAM region of mouse Notch3 protein that mediates binding to the beta trefoil domain (or BTD) of mouse RBP-J kappa |
Record No : 102 |
| Instance ID | 11210 | | Regular Expression | WxP | | Motif Instance | WLP | | Bait Uniprot Accession | O35516 | | Bait Uniprot Identifier | NOTC2_MOUSE | | Bait Gene Name | Notch2 | | Sequence Position | 1706-1708 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; ITC | | Interaction ID | 21210 | | Interacting Domain | Beta-trefoil domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 8898100, 20028974 | | Comments | The conserved WFP sequence motif within the RAM region of mouse Notch2 protein that mediates binding to the beta trefoil domain (or BTD) of mouse RBP-J kappa |
Record No : 103 |
| Instance ID | 11211 | | Regular Expression | WxP | | Motif Instance | WLP | | Bait Uniprot Accession | P31695 | | Bait Uniprot Identifier | NOTC4_MOUSE | | Bait Gene Name | Notch4 | | Sequence Position | 1478-1480 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Mutational analysis; ITC | | Interaction ID | 21211 | | Interacting Domain | Beta-trefoil domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 8898100, 20028974 | | Comments | The conserved WFP sequence motif within the RAM region of mouse Notch4 protein that mediates binding to the beta trefoil domain (or BTD) of mouse RBP-J kappa |
Record No : 104 |
| Instance ID | 11212 | | Regular Expression | WxP | | Motif Instance | WFP | | Bait Uniprot Accession | P07207 | | Bait Uniprot Identifier | NOTCH_DROME | | Bait Gene Name | N | | Sequence Position | 1776-1778 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 21212 | | Interacting Domain | Beta-trefoil domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8749394 | | Comments | The conserved WFP sequence motif in the Drosophila Notch (designated dNotch) protein that mediates binding to the beta trefoil domain (or BTD) of Drosophila Suppressor of hairless protein (Su(H) or dRBP-JK) |
Record No : 105 |
| Instance ID | 11213 | | Regular Expression | WxP | | Motif Instance | WFP | | Bait Uniprot Accession | Q01705 | | Bait Uniprot Identifier | NOTC1_MOUSE | | Bait Gene Name | Notch1 | | Sequence Position | 1758-1760 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 21213 | | Interacting Domain | Beta-trefoil domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8749394 | | Comments | The conserved WFP sequence motif within the RAM region of mouse Notch1 protein that mediates binding to the beta trefoil domain (or BTD) of Drosophila Suppressor of hairless protein (Su(H) or dRBP-JK) |
Record No : 106 |
| Instance ID | 11214 | | Regular Expression | WxP | | Motif Instance | WFP | | Bait Uniprot Accession | P07207 | | Bait Uniprot Identifier | NOTCH_DROME | | Bait Gene Name | N | | Sequence Position | 1776-1778 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H | | Interaction ID | 21214 | | Interacting Domain | Beta-trefoil domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8749394 | | Comments | The conserved WFP sequence motif in the Drosophila Notch (designated dNotch) protein that mediates binding to the beta trefoil domain (or BTD) of mouse RBP-J kappa |
Record No : 107 |
| Instance ID | 11221 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYSVATSL | | Bait Uniprot Accession | Q9NV92 | | Bait Uniprot Identifier | NFIP2_HUMAN | | Bait Gene Name | NDFIP2 | | Sequence Position | 174-183 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21221 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Human E3 ubiquitin-protein ligase ITCH, a group I WW domain protein, and human NEDD4 WW domain-binding protein 5A (NDFIP2) may interact with each other through the WW2 domain and the consensus PPxY or PY motif |
Record No : 108 |
| Instance ID | 11222 | | Regular Expression | PPPYx{4,4}[ST][ILV] | | Motif Instance | PPPYSVATSL | | Bait Uniprot Accession | Q91ZP6 | | Bait Uniprot Identifier | NFIP2_MOUSE | | Bait Gene Name | Ndfip2 | | Sequence Position | 149-158 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21222 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20855944 | | Comments | Mouse E3 ubiquitin-protein ligase Itch, a group I WW domain protein, and mouse NEDD4 WW domain-binding protein 5A (Ndfip2) may interact with each other through the WW2 domain and the consensus PPxY or PY motif |
Record No : 109 |
| Instance ID | 11244 | | Regular Expression | [ILVF]x[ILVF]xx[NC]x[ILV] | | Motif Instance | IKIIENLE | | Bait Uniprot Accession | Q2TFX0 | | Bait Uniprot Identifier | Q2TFX0_PLAFA | | Bait Gene Name | Not Available | | Sequence Position | 30-37 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta-beta-alpha motif | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21244 | | Interacting Domain | Unknown | | Disease Association(s) | Malignant Malaria | | Inhibitor(s) | Unknown | | Reference(s) | 22607144 | | Comments | Leucine Rich Repeat or LRR motif (30-37) in Leucine-rich-repeat protein 1 of Plasmodium falciparum (PfLRR1) that provide site for its interaction with Protein Phosphatase type 1 (PP1) of Plasmodium falciparum |
Record No : 110 |
| Instance ID | 11245 | | Regular Expression | [ILVF]x[ILVF]xx[NC]x[ILV] | | Motif Instance | LYLSSNKI | | Bait Uniprot Accession | Q2TFX0 | | Bait Uniprot Identifier | Q2TFX0_PLAFA | | Bait Gene Name | Not Available | | Sequence Position | 45-52 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta-beta-alpha motif | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21245 | | Interacting Domain | Unknown | | Disease Association(s) | Malignant Malaria | | Inhibitor(s) | Unknown | | Reference(s) | 22607144 | | Comments | Leucine Rich Repeat or LRR motif (45-52) in Leucine-rich-repeat protein 1 of Plasmodium falciparum (PfLRR1) that provide site for its interaction with Protein Phosphatase type 1 (PP1) of Plasmodium falciparum |
Record No : 111 |
| Instance ID | 11246 | | Regular Expression | [ILVF]x[ILVF]xx[NC]x[ILV] | | Motif Instance | LELGYNKI | | Bait Uniprot Accession | Q2TFX0 | | Bait Uniprot Identifier | Q2TFX0_PLAFA | | Bait Gene Name | Not Available | | Sequence Position | 67-74 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta-beta-alpha motif | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21246 | | Interacting Domain | Unknown | | Disease Association(s) | Malignant Malaria | | Inhibitor(s) | Unknown | | Reference(s) | 22607144 | | Comments | Leucine Rich Repeat or LRR motif (67-74) in Leucine-rich-repeat protein 1 of Plasmodium falciparum (PfLRR1) that provide site for its interaction with Protein Phosphatase type 1 (PP1) of Plasmodium falciparum |
Record No : 112 |
| Instance ID | 11247 | | Regular Expression | [ILVF]x[ILVF]xx[NC]x[ILV] | | Motif Instance | LWLGKNKI | | Bait Uniprot Accession | Q2TFX0 | | Bait Uniprot Identifier | Q2TFX0_PLAFA | | Bait Gene Name | Not Available | | Sequence Position | 89-96 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta-beta-alpha motif | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21247 | | Interacting Domain | Unknown | | Disease Association(s) | Malignant Malaria | | Inhibitor(s) | Unknown | | Reference(s) | 22607144 | | Comments | Leucine Rich Repeat or LRR motif (89-96) in Leucine-rich-repeat protein 1 of Plasmodium falciparum (PfLRR1) that provide site for its interaction with Protein Phosphatase type 1 (PP1) of Plasmodium falciparum |
Record No : 113 |
| Instance ID | 11248 | | Regular Expression | [ILVF]x[ILVF]xx[NC]x[ILV] | | Motif Instance | LSVQHNRL | | Bait Uniprot Accession | Q2TFX0 | | Bait Uniprot Identifier | Q2TFX0_PLAFA | | Bait Gene Name | Not Available | | Sequence Position | 110-117 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta-beta-alpha motif | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21248 | | Interacting Domain | Unknown | | Disease Association(s) | Malignant Malaria | | Inhibitor(s) | Unknown | | Reference(s) | 22607144 | | Comments | Leucine Rich Repeat or LRR motif (110-117) in Leucine-rich-repeat protein 1 of Plasmodium falciparum (PfLRR1) that provide site for its interaction with Protein Phosphatase type 1 (PP1) of Plasmodium falciparum |
Record No : 114 |
| Instance ID | 11249 | | Regular Expression | [ILVF]x[ILVF]xx[NC]x[ILV] | | Motif Instance | LYISYNKI | | Bait Uniprot Accession | Q2TFX0 | | Bait Uniprot Identifier | Q2TFX0_PLAFA | | Bait Gene Name | Not Available | | Sequence Position | 134-141 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta-beta-alpha motif | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21249 | | Interacting Domain | Unknown | | Disease Association(s) | Malignant Malaria | | Inhibitor(s) | Unknown | | Reference(s) | 22607144 | | Comments | Leucine Rich Repeat or LRR motif (134-141) in Leucine-rich-repeat protein 1 of Plasmodium falciparum (PfLRR1) that provide site for its interaction with Protein Phosphatase type 1 (PP1) of Plasmodium falciparum |
Record No : 115 |
| Instance ID | 11250 | | Regular Expression | [ILVF]x[ILVF]xx[NC]x[ILV] | | Motif Instance | FDLSYNEI | | Bait Uniprot Accession | Q2TFX0 | | Bait Uniprot Identifier | Q2TFX0_PLAFA | | Bait Gene Name | Not Available | | Sequence Position | 157-164 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta-beta-alpha motif | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21250 | | Interacting Domain | Unknown | | Disease Association(s) | Malignant Malaria | | Inhibitor(s) | Unknown | | Reference(s) | 22607144 | | Comments | Leucine Rich Repeat or LRR motif (157-164) in Leucine-rich-repeat protein 1 of Plasmodium falciparum (PfLRR1) that provide site for its interaction with Protein Phosphatase type 1 (PP1) of Plasmodium falciparum |
Record No : 116 |
| Instance ID | 11251 | | Regular Expression | [ILVF]x[ILVF]xx[NC]x[ILV] | | Motif Instance | LWLNNNNI | | Bait Uniprot Accession | Q2TFX0 | | Bait Uniprot Identifier | Q2TFX0_PLAFA | | Bait Gene Name | Not Available | | Sequence Position | 179-186 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta-beta-alpha motif | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21251 | | Interacting Domain | Unknown | | Disease Association(s) | Malignant Malaria | | Inhibitor(s) | Unknown | | Reference(s) | 22607144 | | Comments | Leucine Rich Repeat or LRR motif (179-186) in Leucine-rich-repeat protein 1 of Plasmodium falciparum (PfLRR1) that provide site for its interaction with Protein Phosphatase type 1 (PP1) of Plasmodium falciparum |
Record No : 117 |
| Instance ID | 11252 | | Regular Expression | [ILVF]x[ILVF]xx[NC]x[ILV] | | Motif Instance | LYLEKNKI | | Bait Uniprot Accession | Q2TFX0 | | Bait Uniprot Identifier | Q2TFX0_PLAFA | | Bait Gene Name | Not Available | | Sequence Position | 204-211 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta-beta-alpha motif | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21252 | | Interacting Domain | Unknown | | Disease Association(s) | Malignant Malaria | | Inhibitor(s) | Unknown | | Reference(s) | 22607144 | | Comments | Leucine Rich Repeat or LRR motif (204-211) in Leucine-rich-repeat protein 1 of Plasmodium falciparum (PfLRR1) that provide site for its interaction with Protein Phosphatase type 1 (PP1) of Plasmodium falciparum |
Record No : 118 |
| Instance ID | 11253 | | Regular Expression | [ILVF]x[ILVF]xx[NC]x[ILV] | | Motif Instance | VSFICNIP | | Bait Uniprot Accession | Q2TFW3 | | Bait Uniprot Identifier | Q2TFW3_PLAFA | | Bait Gene Name | Not Available | | Sequence Position | 28-35 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta-beta-alpha motif | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21253 | | Interacting Domain | Unknown | | Disease Association(s) | Malignant Malaria | | Inhibitor(s) | Unknown | | Reference(s) | 22607144 | | Comments | Leucine Rich Repeat or LRR motif (28-35) in Leucine-rich-repeat protein 7 of Plasmodium falciparum (PfLRR7) that provide site for its interaction with Plasmodium falciparum Actin-1 |
Record No : 119 |
| Instance ID | 11254 | | Regular Expression | [ILVF]x[ILVF]xx[NC]x[ILV] | | Motif Instance | LSLSTNRI | | Bait Uniprot Accession | Q2TFW3 | | Bait Uniprot Identifier | Q2TFW3_PLAFA | | Bait Gene Name | Not Available | | Sequence Position | 53-60 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta-beta-alpha motif | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21254 | | Interacting Domain | Unknown | | Disease Association(s) | Malignant Malaria | | Inhibitor(s) | Unknown | | Reference(s) | 22607144 | | Comments | Leucine Rich Repeat or LRR motif (53-60) in Leucine-rich-repeat protein 7 of Plasmodium falciparum (PfLRR7) that provide site for its interaction with Plasmodium falciparum Actin-1 |
Record No : 120 |
| Instance ID | 11255 | | Regular Expression | [ILVF]x[ILVF]xx[NC]x[ILV] | | Motif Instance | LSLGRNCI | | Bait Uniprot Accession | Q2TFW3 | | Bait Uniprot Identifier | Q2TFW3_PLAFA | | Bait Gene Name | Not Available | | Sequence Position | 75-82 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta-beta-alpha motif | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21255 | | Interacting Domain | Unknown | | Disease Association(s) | Malignant Malaria | | Inhibitor(s) | Unknown | | Reference(s) | 22607144 | | Comments | Leucine Rich Repeat or LRR motif (75-82) in Leucine-rich-repeat protein 7 of Plasmodium falciparum (PfLRR7) that provide site for its interaction with Plasmodium falciparum Actin-1 |
Record No : 121 |
| Instance ID | 11256 | | Regular Expression | [ILVF]x[ILVF]xx[NC]x[ILV] | | Motif Instance | LWLSYNYI | | Bait Uniprot Accession | Q2TFW3 | | Bait Uniprot Identifier | Q2TFW3_PLAFA | | Bait Gene Name | Not Available | | Sequence Position | 98-105 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta-beta-alpha motif | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21256 | | Interacting Domain | Unknown | | Disease Association(s) | Malignant Malaria | | Inhibitor(s) | Unknown | | Reference(s) | 22607144 | | Comments | Leucine Rich Repeat or LRR motif (98-105) in Leucine-rich-repeat protein 7 of Plasmodium falciparum (PfLRR7) that provide site for its interaction with Plasmodium falciparum Actin-1 |
Record No : 122 |
| Instance ID | 11257 | | Regular Expression | [ILVF]x[ILVF]xx[NC]x[ILV] | | Motif Instance | LYIFHNKI | | Bait Uniprot Accession | Q2TFW3 | | Bait Uniprot Identifier | Q2TFW3_PLAFA | | Bait Gene Name | Not Available | | Sequence Position | 120-127 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta-beta-alpha motif | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21257 | | Interacting Domain | Unknown | | Disease Association(s) | Malignant Malaria | | Inhibitor(s) | Unknown | | Reference(s) | 22607144 | | Comments | Leucine Rich Repeat or LRR motif (120-127) in Leucine-rich-repeat protein 7 of Plasmodium falciparum (PfLRR7) that provide site for its interaction with Plasmodium falciparum Actin-1 |
Record No : 123 |
| Instance ID | 11258 | | Regular Expression | [ILVF]x[ILVF]xx[NC]x[ILV] | | Motif Instance | LGLKGNPI | | Bait Uniprot Accession | Q2TFW3 | | Bait Uniprot Identifier | Q2TFW3_PLAFA | | Bait Gene Name | Not Available | | Sequence Position | 145-152 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Beta-beta-alpha motif | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21258 | | Interacting Domain | Unknown | | Disease Association(s) | Malignant Malaria | | Inhibitor(s) | Unknown | | Reference(s) | 22607144 | | Comments | Leucine Rich Repeat or LRR motif (145-152) in Leucine-rich-repeat protein 7 of Plasmodium falciparum (PfLRR7) that provide site for its interaction with Plasmodium falciparum Actin-1 |
Record No : 124 |
| Instance ID | 11262 | | Regular Expression | xG[IV]QVD | | Motif Instance | TGIQVD | | Bait Uniprot Accession | P29476 | | Bait Uniprot Identifier | NOS1_RAT | | Bait Gene Name | Nos1 | | Sequence Position | 231-236 | | Critical Residues | P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; NMR; ITC | | Interaction ID | 21262 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10426949, 20889982, 8864115, 11178896, 9808772 | | Comments | The XG(I/V)QVD motif in rat neuronal nitric oxide synthase (nNOS/Nos1) that interacts with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8) |
Record No : 125 |
| Instance ID | 11263 | | Regular Expression | xG[IV]QVD | | Motif Instance | TGIQVD | | Bait Uniprot Accession | P29476 | | Bait Uniprot Identifier | NOS1_RAT | | Bait Gene Name | Nos1 | | Sequence Position | 231-236 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; SPR; Fluorescence anisotropy; Stopped-flow fluorescence spectroscopy | | Interaction ID | 21263 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20889982 | | Comments | The XG(I/V)QVD motif in rat neuronal nitric oxide synthase (nNOS/Nos1) that interacts with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2) |
Record No : 126 |
| Instance ID | 11269 | | Regular Expression | xG[IV]QVD | | Motif Instance | MGIQVD | | Bait Uniprot Accession | P29475 | | Bait Uniprot Identifier | NOS1_HUMAN | | Bait Gene Name | NOS1 | | Sequence Position | 236-241 | | Critical Residues | P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21269 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11513870, 8864115 | | Comments | The XG(I/V)QVD motif in human Neuronal Nitric oxide synthase (nNOS/NOS1) that interacts with the rat 8 kDa Dynein light chain 1 (Dynll1)/ Protein inhibitor of neuronal nitric oxide synthase (Pin) |
Record No : 127 |
| Instance ID | 11270 | | Regular Expression | xG[IV]QVD | | Motif Instance | TGVQVD | | Bait Uniprot Accession | O19132 | | Bait Uniprot Identifier | NOS1_RABIT | | Bait Gene Name | NOS1 | | Sequence Position | 237-242 | | Critical Residues | P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21270 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11513870, 8864115 | | Comments | The XG(I/V)QVD motif in rabbit Neuronal Nitric oxide synthase (nNOS/NOS1) that interacts with the rat 8 kDa Dynein light chain 1 (Dynll1)/ Protein inhibitor of neuronal nitric oxide synthase (Pin) |
Record No : 128 |
| Instance ID | 11291 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | HGVTQTE | | Bait Uniprot Accession | Q16656 | | Bait Uniprot Identifier | NRF1_HUMAN | | Bait Gene Name | NRF1 | | Sequence Position | 4-10 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Cross linking studies | | Interaction ID | 21291 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11069771, 21533121 | | Comments | The LC8 dynein light chain binding motif in human Nuclear respiratory factor 1 (NRF1) that binds to the mouse 8 kDa Dynein light chain 1 (Dynll1) |
Record No : 129 |
| Instance ID | 11292 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | HGVTQTE | | Bait Uniprot Accession | Q9WU00 | | Bait Uniprot Identifier | NRF1_MOUSE | | Bait Gene Name | Nrf1 | | Sequence Position | 4-10 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Cross linking studies | | Interaction ID | 21292 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11069771, 21533121 | | Comments | The LC8 dynein light chain binding motif in mouse Nuclear respiratory factor 1 (NRF1) that binds to the mouse 8 kDa Dynein light chain 1 (Dynll1) |
Record No : 130 |
| Instance ID | 11294 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | DFDVQTS | | Bait Uniprot Accession | P40477 | | Bait Uniprot Identifier | NU159_YEAST | | Bait Gene Name | NUP159 | | Sequence Position | 1106-1112 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; electron microscopy | | Interaction ID | 21294 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17546040, 21533121 | | Comments | The LC8 dynein light chain binding motif (1106-1112) in Saccharomyces cerevisiae Nuclear pore protein NUP159 that binds to the yeast Dynein light chain 1 (DYN2) |
Record No : 131 |
| Instance ID | 11295 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | ESGIQTD | | Bait Uniprot Accession | P40477 | | Bait Uniprot Identifier | NU159_YEAST | | Bait Gene Name | NUP159 | | Sequence Position | 1119-1125 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; electron microscopy | | Interaction ID | 21295 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17546040, 21533121 | | Comments | The LC8 dynein light chain binding motif (1119-1125) in Saccharomyces cerevisiae Nuclear pore protein NUP159 that binds to the yeast Dynein light chain 1 (DYN2) |
Record No : 132 |
| Instance ID | 11296 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | HNSTQTV | | Bait Uniprot Accession | P40477 | | Bait Uniprot Identifier | NU159_YEAST | | Bait Gene Name | NUP159 | | Sequence Position | 1144-1150 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; electron microscopy | | Interaction ID | 21296 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17546040, 21533121 | | Comments | The LC8 dynein light chain binding motif (1144-1150) in Saccharomyces cerevisiae Nuclear pore protein NUP159 that binds to the yeast Dynein light chain 1 (DYN2) |
Record No : 133 |
| Instance ID | 11297 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | DNGLQTE | | Bait Uniprot Accession | P40477 | | Bait Uniprot Identifier | NU159_YEAST | | Bait Gene Name | NUP159 | | Sequence Position | 1156-1162 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; electron microscopy | | Interaction ID | 21297 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17546040, 21533121 | | Comments | The LC8 dynein light chain binding motif (1156-1162) in Saccharomyces cerevisiae Nuclear pore protein NUP159 that binds to the yeast Dynein light chain 1 (DYN2) |
Record No : 134 |
| Instance ID | 11298 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | NFSVQTF | | Bait Uniprot Accession | P40477 | | Bait Uniprot Identifier | NU159_YEAST | | Bait Gene Name | NUP159 | | Sequence Position | 1168-1174 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; electron microscopy | | Interaction ID | 21298 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17546040, 21533121 | | Comments | The LC8 dynein light chain binding motif (1168-1174) in Saccharomyces cerevisiae Nuclear pore protein NUP159 that binds to the yeast Dynein light chain 1 (DYN2) |
Record No : 135 |
| Instance ID | 11322 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | SKGTQTA | | Bait Uniprot Accession | Q8TD19 | | Bait Uniprot Identifier | NEK9_HUMAN | | Bait Gene Name | NEK9 | | Sequence Position | 944-950 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21322 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in human Serine/threonine-protein kinase NEK9 that interacts with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8) |
Record No : 136 |
| Instance ID | 11323 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | SKGTQTA | | Bait Uniprot Accession | Q8TD19 | | Bait Uniprot Identifier | NEK9_HUMAN | | Bait Gene Name | NEK9 | | Sequence Position | 944-950 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21323 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in human Serine/threonine-protein kinase NEK9 that interacts with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2) |
Record No : 137 |
| Instance ID | 11363 | | Regular Expression | LxxLL | | Motif Instance | LEGLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 21-25 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21363 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box I) in NRIP1 required for the ligand-dependent binding to the oestrogen receptor |
Record No : 138 |
| Instance ID | 11364 | | Regular Expression | LxxLL | | Motif Instance | LEGLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 21-25 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21364 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box I) in NRIP1 required for the ligand-dependent binding to the retinoic acid receptor |
Record No : 139 |
| Instance ID | 11365 | | Regular Expression | LxxLL | | Motif Instance | LEGLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 21-25 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21365 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box I) in NRIP1 required for the ligand-dependent binding to the retinoid X receptor |
Record No : 140 |
| Instance ID | 11366 | | Regular Expression | LxxLL | | Motif Instance | LASLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 133-137 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21366 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box II) in NRIP1 required for the ligand-dependent binding to the oestrogen receptor |
Record No : 141 |
| Instance ID | 11367 | | Regular Expression | LxxLL | | Motif Instance | LASLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 133-137 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21367 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box II) in NRIP1 required for the ligand-dependent binding to the retinoic acid receptor |
Record No : 142 |
| Instance ID | 11368 | | Regular Expression | LxxLL | | Motif Instance | LASLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 133-137 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21368 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box II) in NRIP1 required for the ligand-dependent binding to the retinoid X receptor |
Record No : 143 |
| Instance ID | 11369 | | Regular Expression | LxxLL | | Motif Instance | LKTLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 185-189 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21369 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box III) in NRIP1 required for the ligand-dependent binding to the oestrogen receptor |
Record No : 144 |
| Instance ID | 11370 | | Regular Expression | LxxLL | | Motif Instance | LKTLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 185-189 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21370 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box III) in NRIP1 required for the ligand-dependent binding to the retinoid X receptor |
Record No : 145 |
| Instance ID | 11371 | | Regular Expression | LxxLL | | Motif Instance | LALLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 266-270 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21371 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box IV) in NRIP1 required for the ligand-dependent binding to the oestrogen receptor |
Record No : 146 |
| Instance ID | 11372 | | Regular Expression | LxxLL | | Motif Instance | LALLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 266-270 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21372 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box IV) in NRIP1 required for the ligand-dependent binding to the retinoic acid receptor |
Record No : 147 |
| Instance ID | 11373 | | Regular Expression | LxxLL | | Motif Instance | LALLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 266-270 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21373 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box IV) in NRIP1 required for the ligand-dependent binding to the retinoid X receptor |
Record No : 148 |
| Instance ID | 11374 | | Regular Expression | LxxLL | | Motif Instance | LLHLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 380-384 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography; Y2H | | Interaction ID | 21374 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741, 16990259 | | Comments | Core LXXLL motif sequence (NR Box V) in NRIP1 required for the ligand-dependent binding to the oestrogen receptor |
Record No : 149 |
| Instance ID | 11375 | | Regular Expression | LxxLL | | Motif Instance | LLHLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 380-384 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography; Y2H | | Interaction ID | 21375 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741, 16990259 | | Comments | Core LXXLL motif sequence (NR Box V) in NRIP1 required for the ligand-dependent binding to the retinoic acid receptor |
Record No : 150 |
| Instance ID | 11376 | | Regular Expression | LxxLL | | Motif Instance | LQLLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 501-505 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21376 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box VI) in NRIP1 required for the ligand-dependent binding to the oestrogen receptor |
Record No : 151 |
| Instance ID | 11377 | | Regular Expression | LxxLL | | Motif Instance | LQLLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 501-505 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21377 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box VI) in NRIP1 required for the ligand-dependent binding to the retinoic acid receptor |
Record No : 152 |
| Instance ID | 11378 | | Regular Expression | LxxLL | | Motif Instance | LQLLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 501-505 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21378 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box VI) in NRIP1 required for the ligand-dependent binding to the retinoid X receptor |
Record No : 153 |
| Instance ID | 11379 | | Regular Expression | LxxLL | | Motif Instance | LQLLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 713-717 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21379 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box VII) in NRIP1 required for the ligand-dependent binding to the oestrogen receptor |
Record No : 154 |
| Instance ID | 11380 | | Regular Expression | LxxLL | | Motif Instance | LQLLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 713-717 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21380 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box VII) in NRIP1 required for the ligand-dependent binding to the retinoic acid receptor |
Record No : 155 |
| Instance ID | 11381 | | Regular Expression | LxxLL | | Motif Instance | LQLLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 713-717 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21381 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box VII) in NRIP1 required for the ligand-dependent binding to the retinoid X receptor |
Record No : 156 |
| Instance ID | 11382 | | Regular Expression | LxxLL | | Motif Instance | LSRLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 819-823 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21382 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box VIII) in NRIP1 required for the ligand-dependent binding to the oestrogen receptor |
Record No : 157 |
| Instance ID | 11383 | | Regular Expression | LxxLL | | Motif Instance | LSRLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 819-823 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21383 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box VIII) in NRIP1 required for the ligand-dependent binding to the retinoic acid receptor |
Record No : 158 |
| Instance ID | 11384 | | Regular Expression | LxxLL | | Motif Instance | LSRLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 819-823 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21384 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box VIII) in NRIP1 required for the ligand-dependent binding to the retinoid X receptor |
Record No : 159 |
| Instance ID | 11385 | | Regular Expression | LxxLL | | Motif Instance | LKQLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 936-940 | | Critical Residues | P1; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21385 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box IX) in NRIP1 required for the ligand-dependent binding to the oestrogen receptor |
Record No : 160 |
| Instance ID | 11386 | | Regular Expression | LxxLL | | Motif Instance | LKQLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 936-940 | | Critical Residues | P1; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21386 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box IX) in NRIP1 required for the ligand-dependent binding to the retinoic acid receptor |
Record No : 161 |
| Instance ID | 11387 | | Regular Expression | LxxLL | | Motif Instance | LKQLL | | Bait Uniprot Accession | P48552 | | Bait Uniprot Identifier | NRIP1_HUMAN | | Bait Gene Name | NRIP1 | | Sequence Position | 936-940 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21387 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 11078741 | | Comments | Core LXXLL motif sequence (NR Box IX) in NRIP1 required for the ligand-dependent binding to the retinoid X receptor |
Record No : 162 |
| Instance ID | 11388 | | Regular Expression | LxxLL | | Motif Instance | LVQLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 633-637 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21388 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box I) in NCOA1 required for the ligand-dependent binding to the Glucocorticoid receptor |
Record No : 163 |
| Instance ID | 11389 | | Regular Expression | LxxLL | | Motif Instance | LVQLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 633-637 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21389 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box I) in NCOA1 required for the ligand-dependent binding to the Estrogen receptor |
Record No : 164 |
| Instance ID | 11390 | | Regular Expression | LxxLL | | Motif Instance | LVQLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 633-637 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21390 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box I) in NCOA1 required for the ligand-dependent binding to the Mineralocorticoid receptor |
Record No : 165 |
| Instance ID | 11391 | | Regular Expression | LxxLL | | Motif Instance | LVQLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 633-637 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21391 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box I) in NCOA1 required for the ligand-dependent binding to the Progesterone receptor |
Record No : 166 |
| Instance ID | 11392 | | Regular Expression | LxxLL | | Motif Instance | LVQLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 633-637 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21392 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box I) in NCOA1 required for the ligand-dependent binding to the Vitamin D3 receptor |
Record No : 167 |
| Instance ID | 11393 | | Regular Expression | LxxLL | | Motif Instance | LVQLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 633-637 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21393 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box I) in NCOA1 required for the ligand-dependent binding to the Retinoic acid receptor |
Record No : 168 |
| Instance ID | 11394 | | Regular Expression | LxxLL | | Motif Instance | LVQLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 633-637 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21394 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box I) in NCOA1 required for the ligand-dependent binding to the Retinoid X receptor |
Record No : 169 |
| Instance ID | 11395 | | Regular Expression | LxxLL | | Motif Instance | LVQLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 633-637 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21395 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box I) in NCOA1 required for the ligand-dependent binding to the Thyroid hormone receptor |
Record No : 170 |
| Instance ID | 11396 | | Regular Expression | LxxLL | | Motif Instance | LHRLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 690-694 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21396 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box II) in NCOA1 required for the ligand-dependent binding to the Glucocorticoid receptor |
Record No : 171 |
| Instance ID | 11397 | | Regular Expression | LxxLL | | Motif Instance | LHRLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 690-694 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21397 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box II) in NCOA1 required for the ligand-dependent binding to the Estrogen receptor |
Record No : 172 |
| Instance ID | 11398 | | Regular Expression | LxxLL | | Motif Instance | LHRLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 690-694 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21398 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box II) in NCOA1 required for the ligand-dependent binding to the Mineralocorticoid receptor |
Record No : 173 |
| Instance ID | 11399 | | Regular Expression | LxxLL | | Motif Instance | LHRLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 690-694 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21399 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box II) in NCOA1 required for the ligand-dependent binding to the Progesterone receptor |
Record No : 174 |
| Instance ID | 11400 | | Regular Expression | LxxLL | | Motif Instance | LHRLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 690-694 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21400 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box II) in NCOA1 required for the ligand-dependent binding to the Vitamin D3 receptor |
Record No : 175 |
| Instance ID | 11401 | | Regular Expression | LxxLL | | Motif Instance | LHRLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 690-694 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21401 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box II) in NCOA1 required for the ligand-dependent binding to the Retinoic acid receptor |
Record No : 176 |
| Instance ID | 11402 | | Regular Expression | LxxLL | | Motif Instance | LHRLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 690-694 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21402 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box II) in NCOA1 required for the ligand-dependent binding to the Retinoid X receptor |
Record No : 177 |
| Instance ID | 11403 | | Regular Expression | LxxLL | | Motif Instance | LHRLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 690-694 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21403 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box II) in NCOA1 required for the ligand-dependent binding to the Thyroid hormone receptor |
Record No : 178 |
| Instance ID | 11404 | | Regular Expression | LxxLL | | Motif Instance | LRYLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 749-753 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21404 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box III) in NCOA1 required for the ligand-dependent binding to the Glucocorticoid receptor |
Record No : 179 |
| Instance ID | 11405 | | Regular Expression | LxxLL | | Motif Instance | LRYLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 749-753 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21405 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box III) in NCOA1 required for the ligand-dependent binding to the Estrogen receptor |
Record No : 180 |
| Instance ID | 11406 | | Regular Expression | LxxLL | | Motif Instance | LRYLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 749-753 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21406 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box III) in NCOA1 required for the ligand-dependent binding to the Mineralocorticoid receptor |
Record No : 181 |
| Instance ID | 11407 | | Regular Expression | LxxLL | | Motif Instance | LRYLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 749-753 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21407 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box III) in NCOA1 required for the ligand-dependent binding to the Progesterone receptor |
Record No : 182 |
| Instance ID | 11408 | | Regular Expression | LxxLL | | Motif Instance | LRYLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 749-753 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21408 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box III) in NCOA1 required for the ligand-dependent binding to the Vitamin D3 receptor |
Record No : 183 |
| Instance ID | 11409 | | Regular Expression | LxxLL | | Motif Instance | LRYLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 749-753 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21409 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box III) in NCOA1 required for the ligand-dependent binding to the Retinoic acid receptor |
Record No : 184 |
| Instance ID | 11410 | | Regular Expression | LxxLL | | Motif Instance | LRYLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 749-753 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21410 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box III) in NCOA1 required for the ligand-dependent binding to the Retinoid X receptor |
Record No : 185 |
| Instance ID | 11411 | | Regular Expression | LxxLL | | Motif Instance | LRYLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 749-753 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21411 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box III) in NCOA1 required for the ligand-dependent binding to the Thyroid hormone receptor |
Record No : 186 |
| Instance ID | 11412 | | Regular Expression | LxxLL | | Motif Instance | LQQLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 1435-1439 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21412 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box IV) in NCOA1 required for the ligand-dependent binding to the Glucocorticoid receptor |
Record No : 187 |
| Instance ID | 11413 | | Regular Expression | LxxLL | | Motif Instance | LQQLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 1435-1439 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21413 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box IV) in NCOA1 required for the ligand-dependent binding to the Estrogen receptor |
Record No : 188 |
| Instance ID | 11414 | | Regular Expression | LxxLL | | Motif Instance | LQQLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 1435-1439 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21414 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box IV) in NCOA1 required for the ligand-dependent binding to the Androgen receptor |
Record No : 189 |
| Instance ID | 11415 | | Regular Expression | LxxLL | | Motif Instance | LQQLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 1435-1439 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21415 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box IV) in NCOA1 required for the ligand-dependent binding to the Mineralocorticoid receptor |
Record No : 190 |
| Instance ID | 11416 | | Regular Expression | LxxLL | | Motif Instance | LQQLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 1435-1439 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21416 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box IV) in NCOA1 required for the ligand-dependent binding to the Progesterone receptor |
Record No : 191 |
| Instance ID | 11417 | | Regular Expression | LxxLL | | Motif Instance | LQQLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 1435-1439 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21417 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box IV) in NCOA1 required for the ligand-dependent binding to the Vitamin D3 receptor |
Record No : 192 |
| Instance ID | 11418 | | Regular Expression | LxxLL | | Motif Instance | LQQLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 1435-1439 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21418 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box IV) in NCOA1 required for the ligand-dependent binding to the Retinoic acid receptor |
Record No : 193 |
| Instance ID | 11419 | | Regular Expression | LxxLL | | Motif Instance | LQQLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 1435-1439 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21419 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box IV) in NCOA1 required for the ligand-dependent binding to the Retinoid X receptor |
Record No : 194 |
| Instance ID | 11420 | | Regular Expression | LxxLL | | Motif Instance | LQQLL | | Bait Uniprot Accession | Q15788 | | Bait Uniprot Identifier | NCOA1_HUMAN | | Bait Gene Name | NCOA1 | | Sequence Position | 1435-1439 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H | | Interaction ID | 21420 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9192902, 9482670, 11078741 | | Comments | Core LXXLL motif sequence (NR Box IV) in NCOA1 required for the ligand-dependent binding to the Thyroid hormone receptor |
Record No : 195 |
| Instance ID | 11421 | | Regular Expression | LxxLL | | Motif Instance | LLQLL | | Bait Uniprot Accession | Q15596 | | Bait Uniprot Identifier | NCOA2_HUMAN | | Bait Gene Name | NCOA2 | | Sequence Position | 641-645 | | Critical Residues | P1; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | SPR | | Interaction ID | 21421 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11937504 | | Comments | NR Box B1 region (641-645) of human Nuclear receptor coactivator 2 required for the ligand-dependent binding to the AF-2 transcriptional activation domain of human Estrogen receptor |
Record No : 196 |
| Instance ID | 11422 | | Regular Expression | LxxLL | | Motif Instance | LHRLL | | Bait Uniprot Accession | Q15596 | | Bait Uniprot Identifier | NCOA2_HUMAN | | Bait Gene Name | NCOA2 | | Sequence Position | 690-694 | | Critical Residues | P1; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography; SPR; Mutational analysis | | Interaction ID | 21422 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11937504 | | Comments | NR Box B2 region (690-694) of human Nuclear receptor coactivator 2 required for the ligand-dependent binding to the AF-2 transcriptional activation domain of human Estrogen receptor |
Record No : 197 |
| Instance ID | 11423 | | Regular Expression | LxxYL | | Motif Instance | LLRYL | | Bait Uniprot Accession | Q15596 | | Bait Uniprot Identifier | NCOA2_HUMAN | | Bait Gene Name | NCOA2 | | Sequence Position | 744-748 | | Critical Residues | P1; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography; SPR | | Interaction ID | 21423 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11937504 | | Comments | NR Box B3 region (744-748) of human Nuclear receptor coactivator 2 required for the ligand-dependent binding to the AF-2 transcriptional activation domain of human Estrogen receptor |
Record No : 198 |
| Instance ID | 11424 | | Regular Expression | LxxLL | | Motif Instance | LHRLL | | Bait Uniprot Accession | Q61026 | | Bait Uniprot Identifier | NCOA2_MOUSE | | Bait Gene Name | Ncoa2 | | Sequence Position | 690-694 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21424 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482670 | | Comments | Core LXXLL motif sequence (NR Box II) in NCOA2 required for the ligand-dependent binding to the Glucocorticoid receptor |
Record No : 199 |
| Instance ID | 11425 | | Regular Expression | LxxLL | | Motif Instance | LHRLL | | Bait Uniprot Accession | Q61026 | | Bait Uniprot Identifier | NCOA2_MOUSE | | Bait Gene Name | Ncoa2 | | Sequence Position | 690-694 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21425 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482670 | | Comments | Core LXXLL motif sequence (NR Box II) in NCOA2 required for the ligand-dependent binding to the Estrogen receptor |
Record No : 200 |
| Instance ID | 11426 | | Regular Expression | LxxLL | | Motif Instance | LHRLL | | Bait Uniprot Accession | Q61026 | | Bait Uniprot Identifier | NCOA2_MOUSE | | Bait Gene Name | Ncoa2 | | Sequence Position | 690-694 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21426 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482670 | | Comments | Core LXXLL motif sequence (NR Box II) in NCOA2 required for the ligand-dependent binding to the Mineralocorticoid receptor |
Record No : 201 |
| Instance ID | 11427 | | Regular Expression | LxxLL | | Motif Instance | LHRLL | | Bait Uniprot Accession | Q61026 | | Bait Uniprot Identifier | NCOA2_MOUSE | | Bait Gene Name | Ncoa2 | | Sequence Position | 690-694 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21427 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482670 | | Comments | Core LXXLL motif sequence (NR Box II) in NCOA2 required for the ligand-dependent binding to the Progesterone receptor |
Record No : 202 |
| Instance ID | 11428 | | Regular Expression | LxxLL | | Motif Instance | LHRLL | | Bait Uniprot Accession | Q61026 | | Bait Uniprot Identifier | NCOA2_MOUSE | | Bait Gene Name | Ncoa2 | | Sequence Position | 690-694 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21428 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482670 | | Comments | Core LXXLL motif sequence (NR Box II) in NCOA2 required for the ligand-dependent binding to the Vitamin D3 receptor |
Record No : 203 |
| Instance ID | 11429 | | Regular Expression | LxxLL | | Motif Instance | LHRLL | | Bait Uniprot Accession | Q61026 | | Bait Uniprot Identifier | NCOA2_MOUSE | | Bait Gene Name | Ncoa2 | | Sequence Position | 690-694 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21429 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482670 | | Comments | Core LXXLL motif sequence (NR Box II) in NCOA2 required for the ligand-dependent binding to the Retinoic acid receptor |
Record No : 204 |
| Instance ID | 11430 | | Regular Expression | LxxLL | | Motif Instance | LHRLL | | Bait Uniprot Accession | Q61026 | | Bait Uniprot Identifier | NCOA2_MOUSE | | Bait Gene Name | Ncoa2 | | Sequence Position | 690-694 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21430 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482670 | | Comments | Core LXXLL motif sequence (NR Box II) in NCOA2 required for the ligand-dependent binding to the Retinoid X receptor |
Record No : 205 |
| Instance ID | 11431 | | Regular Expression | LxxLL | | Motif Instance | LHRLL | | Bait Uniprot Accession | Q61026 | | Bait Uniprot Identifier | NCOA2_MOUSE | | Bait Gene Name | Ncoa2 | | Sequence Position | 690-694 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21431 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482670 | | Comments | Core LXXLL motif sequence (NR Box II) in NCOA2 required for the ligand-dependent binding to the Thyroid hormone receptor |
Record No : 206 |
| Instance ID | 11432 | | Regular Expression | LxxLL | | Motif Instance | LRYLL | | Bait Uniprot Accession | Q61026 | | Bait Uniprot Identifier | NCOA2_MOUSE | | Bait Gene Name | Ncoa2 | | Sequence Position | 745-749 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21432 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482670 | | Comments | Core LXXLL motif sequence (NR Box III) in NCOA2 required for the ligand-dependent binding to the Glucocorticoid receptor |
Record No : 207 |
| Instance ID | 11433 | | Regular Expression | LxxLL | | Motif Instance | LRYLL | | Bait Uniprot Accession | Q61026 | | Bait Uniprot Identifier | NCOA2_MOUSE | | Bait Gene Name | Ncoa2 | | Sequence Position | 745-749 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21433 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482670 | | Comments | Core LXXLL motif sequence (NR Box III) in NCOA2 required for the ligand-dependent binding to the Estrogen receptor |
Record No : 208 |
| Instance ID | 11434 | | Regular Expression | LxxLL | | Motif Instance | LRYLL | | Bait Uniprot Accession | Q61026 | | Bait Uniprot Identifier | NCOA2_MOUSE | | Bait Gene Name | Ncoa2 | | Sequence Position | 745-749 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21434 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482670 | | Comments | Core LXXLL motif sequence (NR Box III) in NCOA2 required for the ligand-dependent binding to the Androgen receptor |
Record No : 209 |
| Instance ID | 11435 | | Regular Expression | LxxLL | | Motif Instance | LRYLL | | Bait Uniprot Accession | Q61026 | | Bait Uniprot Identifier | NCOA2_MOUSE | | Bait Gene Name | Ncoa2 | | Sequence Position | 745-749 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21435 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482670 | | Comments | Core LXXLL motif sequence (NR Box III) in NCOA2 required for the ligand-dependent binding to the Mineralocorticoid receptor |
Record No : 210 |
| Instance ID | 11436 | | Regular Expression | LxxLL | | Motif Instance | LRYLL | | Bait Uniprot Accession | Q61026 | | Bait Uniprot Identifier | NCOA2_MOUSE | | Bait Gene Name | Ncoa2 | | Sequence Position | 745-749 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21436 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482670 | | Comments | Core LXXLL motif sequence (NR Box III) in NCOA2 required for the ligand-dependent binding to the Progesterone receptor |
Record No : 211 |
| Instance ID | 11437 | | Regular Expression | LxxLL | | Motif Instance | LRYLL | | Bait Uniprot Accession | Q61026 | | Bait Uniprot Identifier | NCOA2_MOUSE | | Bait Gene Name | Ncoa2 | | Sequence Position | 745-749 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21437 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482670 | | Comments | Core LXXLL motif sequence (NR Box III) in NCOA2 required for the ligand-dependent binding to the Vitamin D3 receptor |
Record No : 212 |
| Instance ID | 11438 | | Regular Expression | LxxLL | | Motif Instance | LRYLL | | Bait Uniprot Accession | Q61026 | | Bait Uniprot Identifier | NCOA2_MOUSE | | Bait Gene Name | Ncoa2 | | Sequence Position | 745-749 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21438 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482670 | | Comments | Core LXXLL motif sequence (NR Box III) in NCOA2 required for the ligand-dependent binding to the Retinoic acid receptor |
Record No : 213 |
| Instance ID | 11439 | | Regular Expression | LxxLL | | Motif Instance | LRYLL | | Bait Uniprot Accession | Q61026 | | Bait Uniprot Identifier | NCOA2_MOUSE | | Bait Gene Name | Ncoa2 | | Sequence Position | 745-749 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21439 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482670 | | Comments | Core LXXLL motif sequence (NR Box III) in NCOA2 required for the ligand-dependent binding to the Retinoid X receptor |
Record No : 214 |
| Instance ID | 11440 | | Regular Expression | LxxLL | | Motif Instance | LRYLL | | Bait Uniprot Accession | Q61026 | | Bait Uniprot Identifier | NCOA2_MOUSE | | Bait Gene Name | Ncoa2 | | Sequence Position | 745-749 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Mutational analysis | | Interaction ID | 21440 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9482670 | | Comments | Core LXXLL motif sequence (NR Box III) in NCOA2 required for the ligand-dependent binding to the Thyroid hormone receptor |
Record No : 215 |
| Instance ID | 11441 | | Regular Expression | LxxLL | | Motif Instance | LHKLL | | Bait Uniprot Accession | Q9Y6Q9 | | Bait Uniprot Identifier | NCOA3_HUMAN | | Bait Gene Name | NCOA3 | | Sequence Position | 685-689 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography; Mutational analysis; Competition binding assay; Mammalian two-hybrid assay | | Interaction ID | 21441 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 20086010 | | Comments | Core LXXLL motif sequence (NR Box I) in SRC3/AIB1/NCOA3 required for the ligand-dependent binding to the Androgen receptor(AR) & this functional relationship between AR and SRC3 leads to the development and growth of prostate cancer. |
Record No : 216 |
| Instance ID | 11442 | | Regular Expression | LxxLL | | Motif Instance | LHTLL | | Bait Uniprot Accession | Q9Y6Q9 | | Bait Uniprot Identifier | NCOA3_HUMAN | | Bait Gene Name | NCOA3 | | Sequence Position | 1057-1061 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography; Mutational analysis; Competition binding assay; Mammalian two-hybrid assay | | Interaction ID | 21442 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 20086010 | | Comments | Core LXXLL motif sequence (NR Box III) in SRC3/AIB1/NCOA3 required for the ligand-dependent binding to the Androgen receptor(AR) & this functional relationship between AR and SRC3 leads to the development and growth of prostate cancer. |
Record No : 217 |
| Instance ID | 11443 | | Regular Expression | LxxLL | | Motif Instance | LHKLL | | Bait Uniprot Accession | Q9Y6Q9 | | Bait Uniprot Identifier | NCOA3_HUMAN | | Bait Gene Name | NCOA3 | | Sequence Position | 685-689 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mammalian two-hybrid assay | | Interaction ID | 21443 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 20086010 | | Comments | Core LXXLL motif sequence (NR Box I) in SRC3/AIB1/NCOA3 required for the ligand-dependent binding to the Estrogen receptor(ER-alpha), which may serve as the physical basis for functional coupling of these two proteins for breast cancer development and progression. |
Record No : 218 |
| Instance ID | 11444 | | Regular Expression | LxxLL | | Motif Instance | LRYLL | | Bait Uniprot Accession | Q9Y6Q9 | | Bait Uniprot Identifier | NCOA3_HUMAN | | Bait Gene Name | NCOA3 | | Sequence Position | 738-742 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mammalian two-hybrid assay | | Interaction ID | 21444 | | Interacting Domain | AF-2 transcriptional activation domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 20086010 | | Comments | Core LXXLL motif sequence (NR Box II) in SRC3/AIB1/NCOA3 required for the ligand-dependent binding to the Estrogen receptor(ER-alpha), which may serve as the physical basis for functional coupling of these two proteins for breast cancer development and progression. |
Record No : 219 |
| Instance ID | 11470 | | Regular Expression | [RK]Sx[ST]xP | | Motif Instance | RSHSYP | | Bait Uniprot Accession | P03077 | | Bait Uniprot Identifier | MT_POVMA | | Bait Gene Name | Not Available | | Sequence Position | 254-259 | | Critical Residues | Unknown | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Extended conformation | | Experimental Method(s) | X-ray crystallography; Sequence based prediction | | Interaction ID | 21470 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8601312, 9428519 | | Comments | 14-3-3 binding motif in Polyoma middle T antigen (pS-257) which binds 14-3-3 protein zeta |
Record No : 220 |
| Instance ID | 11493 | | Regular Expression | [ST]x[VL]$ | | Motif Instance | TLV | | Bait Uniprot Accession | Q9Z206 | | Bait Uniprot Identifier | ARHG8_MOUSE | | Bait Gene Name | Net1 | | Sequence Position | 593-595 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Y2H; Co-IP; Pull down(GST tag) | | Interaction ID | 21493 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11350080 | | Comments | Consensus tripeptide for PDZ domain binding at the extreme carboxy-terminus of mNET1 that binds to the first PDZ domain of MAGI-1 |
Record No : 221 |
| Instance ID | 11683 | | Regular Expression | Wx{2,3}[FW] | | Motif Instance | WGDF | | Bait Uniprot Accession | Q8NC96 | | Bait Uniprot Identifier | NECP1_HUMAN | | Bait Gene Name | NECAP1 | | Sequence Position | 252-255 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21683 | | Interacting Domain | Gamma-adaptin ear(GAE) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14973137 | | Comments | GAE-binding motif in Adaptin ear-binding coat-associated protein 1 (NECAP1) that interacts with the gamma-ear domain of the AP-1 complex subunit gamma-1 or Gamma1-adaptin |
Record No : 222 |
| Instance ID | 11689 | | Regular Expression | Wx{2,3}[FW] | | Motif Instance | WVQF | | Bait Uniprot Accession | Q8NC96 | | Bait Uniprot Identifier | NECP1_HUMAN | | Bait Gene Name | NECAP1 | | Sequence Position | 272-275 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | NMR; Mutational analysis | | Interaction ID | 21689 | | Interacting Domain | Alpha-ear domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15359277 | | Comments | The C-terminal WXXF motif of Adaptin ear-binding coat-associated protein 1 (NECAP1) that mediates binding to the alpha-ear domain of AP-2 complex subunit alpha-1 or Alpha1-adaptin |
Record No : 223 |
| Instance ID | 11690 | | Regular Expression | Wx{2,3}[FW] | | Motif Instance | WVQF | | Bait Uniprot Accession | Q9NVZ3 | | Bait Uniprot Identifier | NECP2_HUMAN | | Bait Gene Name | NECAP2 | | Sequence Position | 260-263 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | NMR; Mutational analysis | | Interaction ID | 21690 | | Interacting Domain | Alpha-ear domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15359277 | | Comments | The C-terminal WXXF motif of Adaptin ear-binding coat-associated protein 2 (NECAP2) that mediates binding to the alpha-ear domain of AP-2 complex subunit alpha-1 or Alpha1-adaptin |
Record No : 224 |
| Instance ID | 11753 | | Regular Expression | xPxxP | | Motif Instance | RPQVP | | Bait Uniprot Accession | P03407 | | Bait Uniprot Identifier | NEF_HV1A2 | | Bait Gene Name | nef | | Sequence Position | 75-79 | | Critical Residues | P2; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21753 | | Interacting Domain | SH3 domain | | Disease Association(s) | HIV-1 pathogenicity | | Inhibitor(s) | Unknown | | Reference(s) | 7588629 | | Comments | The SH3 domain-binding proline-rich (xPxxP) motif in HIV-1 Nef protein that is necessary for its interaction with human Hck SH3, leading to aberrant activation of HCK, which enhances HIV-1 replication and contributes to HIV-1 pathogenicity |
Record No : 225 |
| Instance ID | 11798 | | Regular Expression | [DE][LI]xCxE | | Motif Instance | DLTCHE | | Bait Uniprot Accession | P03255 | | Bait Uniprot Identifier | E1A_ADE05 | | Bait Gene Name | Not Available | | Sequence Position | 121-126 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Competition binding assay | | Interaction ID | 21798 | | Interacting Domain | B-box portion of the Rb pocket domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 2138977, 2198278 | | Comments | The LxCxE motif of adenovirus E1A protein that binds to the human retinoblastoma suppressor protein (pRb) and is required for transformation |
Record No : 226 |
| Instance ID | 11809 | | Regular Expression | [RK]x{0,1}[VIL][^P][FW] | | Motif Instance | RVRF | | Bait Uniprot Accession | Q15233 | | Bait Uniprot Identifier | NONO_HUMAN | | Bait Gene Name | NONO | | Sequence Position | 140-143 | | Critical Residues | P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Pull down(GST tag) | | Interaction ID | 21809 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21566083 | | Comments | The RVXF motif in non-POU-domain-containing, octamer binding protein (p54nrb) that mediates its binding to protein phosphatase PP1-alpha catalytic subunit (PPP1CA) |
Record No : 227 |
| Instance ID | 11853 | | Regular Expression | FGPxL | | Motif Instance | FGPSL | | Bait Uniprot Accession | Q8NEY1 | | Bait Uniprot Identifier | NAV1_HUMAN | | Bait Gene Name | NAV1 | | Sequence Position | 1395-1399 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Phage Display; SPOT Analysis | | Interaction ID | 21853 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15845542 | | Comments | The consensus motif in human Neuron navigator 1 that represent putative target sites for binding of Cyclophilin A, a peptidyl-prolyl cis/trans-isomerase that is involved in multiple signaling events of eukaryotic cells |
Record No : 228 |
| Instance ID | 11855 | | Regular Expression | [ND]xY[ST]xxP | | Motif Instance | NLYSSLP | | Bait Uniprot Accession | P07174 | | Bait Uniprot Identifier | TNR16_RAT | | Bait Gene Name | Ngfr | | Sequence Position | 335-341 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Tyr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Sequence based prediction | | Interaction ID | 21855 | | Interacting Domain | TKB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15737992, 15337528 | | Comments | Consensus sequence for phosphotyrosine recognition by the c-Cbl TKB domain in rat p75 neurotrophin receptor, suggesting a c-Cbl-dependent ubiquitination of p75NTR involved in the regulation of p75NTR signalling |
Record No : 229 |
| Instance ID | 11891 | | Regular Expression | YxxM | | Motif Instance | YMPM | | Bait Uniprot Accession | P03077 | | Bait Uniprot Identifier | MT_POVMA | | Bait Gene Name | Not Available | | Sequence Position | 315-318 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Competition binding assay | | Interaction ID | 21891 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1380456 | | Comments | Phosphorylated YXXM motif (315-318) in Middle T antigen of Murine polyomavirus that may mediate binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase |
Record No : 230 |
| Instance ID | 11918 | | Regular Expression | HLETTF | | Motif Instance | HLETTF | | Bait Uniprot Accession | P29476 | | Bait Uniprot Identifier | NOS1_RAT | | Bait Gene Name | Nos1 | | Sequence Position | 106-111 | | Critical Residues | P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta-hairpin finger | | Experimental Method(s) | X-ray crystallography; Mutational analysis; Fluorescence-based binding assay; Competition binding assay | | Interaction ID | 21918 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Becker’s muscular dystrophy | | Reference(s) | 11352727, 10221915 | | Comments | The PDZ protein interaction domain of rat neuronal nitric oxide synthase (nNOS) that binds to the syntrophin PDZ domain |
Record No : 231 |
| Instance ID | 11919 | | Regular Expression | HLETTF | | Motif Instance | HLETTF | | Bait Uniprot Accession | P29476 | | Bait Uniprot Identifier | NOS1_RAT | | Bait Gene Name | Nos1 | | Sequence Position | 106-111 | | Critical Residues | P3; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta-hairpin finger | | Experimental Method(s) | Mutational analysis; Y2H; Pull down(GST tag) | | Interaction ID | 21919 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Becker’s muscular dystrophy | | Reference(s) | 10488080 | | Comments | "An internal motif adjacent to the rat nNOS (Nos1) PDZ domain, a structured ""pseudo-peptide"" extension of the nNOS PDZ, that interacts with the peptide-binding pocket of rat PSD-95 (Dlg4) PDZ2 domain by a novel PDZ-PDZ interaction" |
Record No : 232 |
| Instance ID | 11937 | | Regular Expression | NPxY | | Motif Instance | NPQY | | Bait Uniprot Accession | P04629 | | Bait Uniprot Identifier | NTRK1_HUMAN | | Bait Gene Name | NTRK1 | | Sequence Position | 493-496 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Competition binding assay | | Interaction ID | 21937 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8226808, 7537849 | | Comments | The tyrosine-phosphorylated NPXY motif of High affinity nerve growth factor receptor (NTRK1) that mediates its interaction with the PTB domain of SHC-transforming protein 1 |
Record No : 233 |
| Instance ID | 11940 | | Regular Expression | NPxY | | Motif Instance | NPTY | | Bait Uniprot Accession | P03077 | | Bait Uniprot Identifier | MT_POVMA | | Bait Gene Name | Not Available | | Sequence Position | 247-250 | | Critical Residues | P2; P4 | | Motif PTM(s) | Phosphorylation at Tyr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21940 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8022784, 7537849 | | Comments | The tyrosine-phosphorylated NPXY motif of Middle T antigen of Murine polyomavirus that mediates its interaction with the PTB domain of SHC-transforming protein 1 |
Record No : 234 |
| Instance ID | 11984 | | Regular Expression | [DEN][DEN]x{2,3}[ILMVA][DEN][DEN]L | | Motif Instance | DEDDEFNDL | | Bait Uniprot Accession | O43070 | | Bait Uniprot Identifier | NBS1_SCHPO | | Bait Gene Name | nbs1 | | Sequence Position | 601-609 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21984 | | Interacting Domain | HEAT repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15964794 | | Comments | Two pairs of HEAT repeats in fission yeast ATM (Tel1) interact with an acidic patch at the C terminus of Nbs1 |
Record No : 235 |
| Instance ID | 11985 | | Regular Expression | PxLx[IL]T | | Motif Instance | PSLPIT | | Bait Uniprot Accession | P0C215 | | Bait Uniprot Identifier | P12I_HTL1A | | Bait Gene Name | Not Available | | Sequence Position | 70-75 | | Critical Residues | P1; P3; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21985 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12601010 | | Comments | The conserved calcineurin-binding motif in human T lymphotropic virus type 1 Accessory protein p12I that mediates its interaction with human Calmodulin-dependent calcineurin A subunit alpha isoform (PPP3CA) and modulates NFAT activation to promote early virus infection of T lymphocytes, providing a novel mechanism for retrovirus-mediated cell activation |
Record No : 236 |
| Instance ID | 11987 | | Regular Expression | TPxx[SE] | | Motif Instance | TPSPE | | Bait Uniprot Accession | Q01705 | | Bait Uniprot Identifier | NOTC1_MOUSE | | Bait Gene Name | Notch1 | | Sequence Position | 2487-2491 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21987 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11461910 | | Comments | The mouse Neurogenic locus notch homolog protein 1 (Notch1) intracellular domain is ubiquitinated and negatively regulated by the mouse F-box/WD repeat-containing protein 7 (Fbxw7) through a phosphodegron motif recognized by WD40 beta propeller |
Record No : 237 |
| Instance ID | 11999 | | Regular Expression | ETGE | | Motif Instance | ETGE | | Bait Uniprot Accession | Q60795 | | Bait Uniprot Identifier | NF2L2_MOUSE | | Bait Gene Name | Nfe2l2 | | Sequence Position | 79-82 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta turn | | Experimental Method(s) | Mutation analysis; Co-IP; X-ray crystallography; ITC | | Interaction ID | 21999 | | Interacting Domain | DGR domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16507366 | | Comments | The ETGE motif within the N-terminal Neh2 domain of mouse Nrf2, a basic region-leucine zipper (bZIP) transcription factor, binds the DGR domain in the beta propeller of mouse Keap1, which is essential to suppress Nrf2 activity |
Record No : 238 |
| Instance ID | 12007 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | PPSLS | | Bait Uniprot Accession | P20393 | | Bait Uniprot Identifier | NR1D1_HUMAN | | Bait Gene Name | NR1D1 | | Sequence Position | 72-76 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22007 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25260595 | | Comments | The PxDLS linear motif in human Rev-erbA-alpha (Nuclear receptor subfamily 1 group D member 1 or NR1D1) that participates in its interaction with the Basic-helix-loop-helix-PAS protein ARNTL or BMAL1 and thus plays an important role in circadian rhythmicity |
Record No : 239 |
| Instance ID | 12049 | | Regular Expression | FxxWxDYxxL | | Motif Instance | FSSWNDYLGL | | Bait Uniprot Accession | Q8WY41 | | Bait Uniprot Identifier | NANO1_HUMAN | | Bait Gene Name | NANOS1 | | Sequence Position | 40-49 | | Critical Residues | P1; P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography; Mutational analysis; Pull down(SBP tag) | | Interaction ID | 22049 | | Interacting Domain | NOT1 superfamily homology domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24736845 | | Comments | Human Nanos homolog 1 (NANOS1) interacts with the human CCR4-NOT transcription complex subunit 1 (CNOT1) SHD directly through the conserved CNOT1-interacting motif (NIM) |
Record No : 240 |
| Instance ID | 12050 | | Regular Expression | FxxWxDYxxL | | Motif Instance | FDMWKDYFNL | | Bait Uniprot Accession | P60321 | | Bait Uniprot Identifier | NANO2_HUMAN | | Bait Gene Name | NANOS2 | | Sequence Position | 6-15 | | Critical Residues | P1; P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(SBP tag) | | Interaction ID | 22050 | | Interacting Domain | NOT1 superfamily homology domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24736845 | | Comments | Human Nanos homolog 2 (NANOS2) interacts with the human CCR4-NOT transcription complex subunit 1 (CNOT1) SHD directly through the conserved CNOT1-interacting motif (NIM) |
Record No : 241 |
| Instance ID | 12051 | | Regular Expression | FxxWxDYxxL | | Motif Instance | FDLWTDYLGL | | Bait Uniprot Accession | P60323 | | Bait Uniprot Identifier | NANO3_HUMAN | | Bait Gene Name | NANOS3 | | Sequence Position | 4-13 | | Critical Residues | P1; P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(SBP tag) | | Interaction ID | 22051 | | Interacting Domain | NOT1 superfamily homology domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24736845 | | Comments | Human Nanos homolog 3 (NANOS3) interacts with the human CCR4-NOT transcription complex subunit 1 (CNOT1) SHD directly through the conserved CNOT1-interacting motif (NIM) |
Record No : 242 |
| Instance ID | 12057 | | Regular Expression | [IL]DLPxY | | Motif Instance | LDLPPY | | Bait Uniprot Accession | Q96PU5 | | Bait Uniprot Identifier | NED4L_HUMAN | | Bait Gene Name | NEDD4L | | Sequence Position | 846-851 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | NMR | | Interaction ID | 22057 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25295397 | | Comments | The PY motif in the HECT domain of human E3 ubiquitin-protein ligase NEDD4L/KIAA0439 binds to the WW3 domain of human E3 ubiquitin-protein ligase NEDD4L/KIAA0439, suggesting a possible auto-ubquitination mechanism using two molecules, a partially unfolded one and a fully functional NEDD4L counterpart |
Record No : 243 |
| Instance ID | 12143 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LLCAE | | Bait Uniprot Accession | Q99AM3 | | Bait Uniprot Identifier | Q99AM3_HHV8 | | Bait Gene Name | Not Available | | Sequence Position | 109-113 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22143 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23318443 | | Comments | The LxCxE motif in the B-cell specific latent nuclear protein LANA2 of Human herpesvirus 8 (HHV-8)/ Kaposi's sarcoma herpesvirus (KSHV) that binds to the B-box portion of the pocket domain of the human Retinoblastoma-like protein 1 (p107/RBL1) |
Record No : 244 |
| Instance ID | 12144 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LLCAE | | Bait Uniprot Accession | Q99AM3 | | Bait Uniprot Identifier | Q99AM3_HHV8 | | Bait Gene Name | Not Available | | Sequence Position | 109-113 | | Critical Residues | P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22144 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23318443 | | Comments | The LxCxE motif in the B-cell specific latent nuclear protein LANA2 of Human herpesvirus 8 (HHV-8)/ Kaposi's sarcoma herpesvirus (KSHV) that binds to the B-box portion of the pocket domain of the human Retinoblastoma-like protein 2 (p130/RBL2) |
Record No : 245 |
| Instance ID | 12169 | | Regular Expression | Rx{0,3}AxAAxxR | | Motif Instance | RKEEKEKKRRR | | Bait Uniprot Accession | Q9Y5A7 | | Bait Uniprot Identifier | NUB1_HUMAN | | Bait Gene Name | NUB1 | | Sequence Position | 422-432 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); NMR | | Interaction ID | 22169 | | Interacting Domain | ND1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24100225 | | Comments | The VCP-interacting motif (VIM) in Human NEDD8 ultimate buster 1 (NUB1) that mediates binding to human Transitional endoplasmic reticulum ATPase VCP |
Record No : 246 |
| Instance ID | 12200 | | Regular Expression | EEVD | | Motif Instance | EEVD | | Bait Uniprot Accession | O43639 | | Bait Uniprot Identifier | NCK2_HUMAN | | Bait Gene Name | NCK2 | | Sequence Position | 167-170 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22200 | | Interacting Domain | Ankyrin repeat-containing domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24338975 | | Comments | The EEVD sequence of Cytoplasmic protein NCK2 that binds to the Ankyrin repeat-containing domain of human Gankyrin/ 26S proteasome non-ATPase regulatory subunit 10 (PSMD10) |
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