|
Total : 87 Records
Record No : 1 |
| Instance ID | 10005 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSASEP | | Bait Uniprot Accession | P04049 | | Bait Uniprot Identifier | RAF1_HUMAN | | Bait Gene Name | RAF1 | | Sequence Position | 618-623 | | Critical Residues | P1; P2; P4; P6 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 20005 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer; Noonan Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 8601312, 17603483 | | Comments | 14-3-3 binding motif in RAF1 (pS-Raf-621) that binds 14-3-3 protein zeta |
Record No : 2 |
| Instance ID | 10006 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSASEP | | Bait Uniprot Accession | P04049 | | Bait Uniprot Identifier | RAF1_HUMAN | | Bait Gene Name | RAF1 | | Sequence Position | 618-623 | | Critical Residues | P1; P2; P4; P6 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 20006 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer; Noonan Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 8601312, 17603483 | | Comments | 14-3-3 binding motif in RAF1 (pS-Raf-621) that binds 14-3-3 protein eta |
Record No : 3 |
| Instance ID | 10007 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSASEP | | Bait Uniprot Accession | P04049 | | Bait Uniprot Identifier | RAF1_HUMAN | | Bait Gene Name | RAF1 | | Sequence Position | 618-623 | | Critical Residues | P1; P2; P4; P6 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 20007 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer; Noonan Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 8601312, 17603483 | | Comments | 14-3-3 binding motif in RAF1 (pS-Raf-621) that binds 14-3-3 protein beta |
Record No : 4 |
| Instance ID | 10008 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSASEP | | Bait Uniprot Accession | P04049 | | Bait Uniprot Identifier | RAF1_HUMAN | | Bait Gene Name | RAF1 | | Sequence Position | 618-623 | | Critical Residues | P1; P2; P4; P6 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | SPR | | Interaction ID | 20008 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer; Noonan Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 8601312, 17603483 | | Comments | 14-3-3 binding motif in RAF1 (pS-Raf-621) that binds 14-3-3 protein tau |
Record No : 5 |
| Instance ID | 10020 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSTSTP | | Bait Uniprot Accession | P04049 | | Bait Uniprot Identifier | RAF1_HUMAN | | Bait Gene Name | RAF1 | | Sequence Position | 256-261 | | Critical Residues | P1; P2; P4; P6 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Display technology | | Interaction ID | 20020 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer; Noonan Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 20679480, 8601312, 17603483 | | Comments | 14-3-3 binding motif in RAF1 (pS-Raf-259) that binds 14-3-3 protein zeta |
Record No : 6 |
| Instance ID | 10021 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSTSTP | | Bait Uniprot Accession | P04049 | | Bait Uniprot Identifier | RAF1_HUMAN | | Bait Gene Name | RAF1 | | Sequence Position | 256-261 | | Critical Residues | P1; P2; P4; P6 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Display technology | | Interaction ID | 20021 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer; Noonan Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 20679480, 8601312, 17603483 | | Comments | 14-3-3 binding motif in RAF1 (pS-Raf-259) that binds 14-3-3 protein eta |
Record No : 7 |
| Instance ID | 10022 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSTSTP | | Bait Uniprot Accession | P04049 | | Bait Uniprot Identifier | RAF1_HUMAN | | Bait Gene Name | RAF1 | | Sequence Position | 256-261 | | Critical Residues | P1; P2; P4; P6 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Display technology | | Interaction ID | 20022 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer; Noonan Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 20679480, 8601312, 17603483 | | Comments | 14-3-3 binding motif in RAF1 (pS-Raf-259) that binds 14-3-3 protein beta |
Record No : 8 |
| Instance ID | 10023 | | Regular Expression | Rx[^P]([ST])[^P]P | | Motif Instance | RSTSTP | | Bait Uniprot Accession | P04049 | | Bait Uniprot Identifier | RAF1_HUMAN | | Bait Gene Name | RAF1 | | Sequence Position | 256-261 | | Critical Residues | P1; P2; P4; P6 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Display technology | | Interaction ID | 20023 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Cancer; Noonan Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 20679480, 8601312, 17603483 | | Comments | 14-3-3 binding motif in RAF1 (pS-Raf-259) that binds 14-3-3 protein tau |
Record No : 9 |
| Instance ID | 10033 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RSAGSIP | | Bait Uniprot Accession | Q04206 | | Bait Uniprot Identifier | TF65_HUMAN | | Bait Gene Name | RELA | | Sequence Position | 41-47 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Ser-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20033 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16931600 | | Comments | 14-3-3 binding site in human Transcription factor NF-kappa-B p65 subunit (or RELA) that binds to 14-3-3 protein eta in response to TNFalpha stimulation, which indicates that 14-3-3 proteins facilitate the nuclear export of IkappaBalpha-p65 complexes and are required for the appropriate regulation of NFkappaB signaling |
Record No : 10 |
| Instance ID | 10051 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSSTPP | | Bait Uniprot Accession | P43565 | | Bait Uniprot Identifier | RIM15_YEAST | | Bait Gene Name | RIM15 | | Sequence Position | 1072-1077 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20051 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16308562 | | Comments | Phosphorylation-dependent 14-3-3-binding site in yeast PAS kinase RIM15 (which functions as a key controller of many aspects of the quiescent G0 state) that mediates binding to BMH2 (the 14-3-3 isoform from Saccharomyces cerevisiae) thereby effectively sequestering Rim15 in the cytoplasm (dephosphorylation of the 14-3-3-binding site in Rim15, in turn, enabling nuclear import of Rim15) |
Record No : 11 |
| Instance ID | 10114 | | Regular Expression | Fxx[FWY][ST][FY] | | Motif Instance | FVGFTY | | Bait Uniprot Accession | Q13464 | | Bait Uniprot Identifier | ROCK1_HUMAN | | Bait Gene Name | ROCK1 | | Sequence Position | 394-399 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 20114 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 18204440 | | Comments | PDK1 competes directly with RhoE for binding to human ROCK1 through the AGC Kinase docking motif that interacts with the PIF pocket of PDK1, thus altering the localization of ROCK1 and reducing its ability to drive cortical acto-myosin contraction |
Record No : 12 |
| Instance ID | 10115 | | Regular Expression | Fxx[FWY][ST][FY] | | Motif Instance | FRGFSF | | Bait Uniprot Accession | P18654 | | Bait Uniprot Identifier | KS6A3_MOUSE | | Bait Gene Name | Rps6ka3 | | Sequence Position | 382-387 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Ser-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Protein kinase assay; Co-IP; Mutation analysis | | Interaction ID | 20115 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10856237 | | Comments | Hydrophobic motif of the 90 kDa ribosomal S6 kinase-2 (RSK2), a growth factor-stimulated protein kinase, that acts as a phosphorylation-dependent docking site and activator of PDK1 |
Record No : 13 |
| Instance ID | 10116 | | Regular Expression | Fxx[FWY][ST][FY] | | Motif Instance | FLGFTY | | Bait Uniprot Accession | P67999 | | Bait Uniprot Identifier | KS6B1_RAT | | Bait Gene Name | Rps6kb1 | | Sequence Position | 408-413 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Thr-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Protein kinase assay; Competition binding; Mutation analysis; SPR | | Interaction ID | 20116 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11500365 | | Comments | Phosphorylation of the hydrophobic motif of p70 ribosomal S6 kinase 1 promotes its interaction with the PIF-binding pocket of PDK1 |
Record No : 14 |
| Instance ID | 10208 | | Regular Expression | ^M{0,1}Ax[AP]x | | Motif Instance | MAVAF | | Bait Uniprot Accession | Q24475 | | Bait Uniprot Identifier | RPR_DROME | | Bait Gene Name | rpr | | Sequence Position | 1-5 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20208 | | Interacting Domain | BIR domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15107838 | | Comments | IAP-binding motif in Drosophila Cell death protein rpr that binds to the BIR2 domain of Drosophila Iap2 (dIAP2) |
Record No : 15 |
| Instance ID | 10215 | | Regular Expression | x(S)xxF | | Motif Instance | SSPVF | | Bait Uniprot Accession | Q99708 | | Bait Uniprot Identifier | COM1_HUMAN | | Bait Gene Name | RBBP8 | | Sequence Position | 326-330 | | Critical Residues | P2; P5 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; X-ray crystallography | | Interaction ID | 20215 | | Interacting Domain | BRCT domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16101277 | | Comments | Phosphorylated serine (pS) sequence in human DNA endonuclease RBBP8 or CtIP that mediates specific interaction with the carboxyl-terminal domain (BRCT) of the Breast Cancer Gene 1 (BRCA1) protein, and the side chain of Arg1775 in the cancer-associated BRCA1 mutation M1775R sterically clashes with the phenyl ring of CtIP Phe330, disrupting the BRCA1-CtIP interaction |
Record No : 16 |
| Instance ID | 10262 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | PLDLS | | Bait Uniprot Accession | Q99708 | | Bait Uniprot Identifier | COM1_HUMAN | | Bait Gene Name | RBBP8 | | Sequence Position | 490-494 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Competition binding | | Interaction ID | 20262 | | Interacting Domain | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | | Disease Association(s) | Unknown | | Inhibitor(s) | E1A exon 2 peptide | | Reference(s) | 9535825 | | Comments | Human CtBP was found to specifically interact with human CtIP (CtBP-interacting protein) or DNA endonuclease RBBP8 through a conserved PLDLS motif and the CtBP-CtIP complex is disrupted by E1A resulting in tumorigenesis-restraining activity |
Record No : 17 |
| Instance ID | 10285 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | KKLRF | | Bait Uniprot Accession | P06400 | | Bait Uniprot Identifier | RB_HUMAN | | Bait Gene Name | RB1 | | Sequence Position | 873-877 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; X-ray crystallography; Mutation analysis | | Interaction ID | 20285 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12501191, 9891042 | | Comments | The cyclin recognition site (RxL motif) found in human Retinoblastoma-associated protein that interacts with Cyclin-A2 and thereby increases the specificity of phosphorylation by cyclin/CDK complexes |
Record No : 18 |
| Instance ID | 10290 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RTLF | | Bait Uniprot Accession | P50445 | | Bait Uniprot Identifier | RUX_DROME | | Bait Gene Name | rux | | Sequence Position | 248-251 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20290 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11027291 | | Comments | Drosophila Roughex (Rux) protein acts as a distinct and specialized cell cycle inhibitor for cyclin A-dependent kinase activity through a physical association with cyclin A via its RxL motif |
Record No : 19 |
| Instance ID | 10296 | | Regular Expression | [RK]xLx{0,1}[FYLIVMP] | | Motif Instance | RRLF | | Bait Uniprot Accession | P28749 | | Bait Uniprot Identifier | RBL1_HUMAN | | Bait Gene Name | RBL1 | | Sequence Position | 658-661 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC; X-ray crystallography; Mutation analysis | | Interaction ID | 20296 | | Interacting Domain | Cyclin, N-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12501191, 11884610 | | Comments | The cyclin recognition site found in human Retinoblastoma-like protein 1 (p107) through which it physically associates with cyclin A |
Record No : 20 |
| Instance ID | 10359 | | Regular Expression | xNPFx | | Motif Instance | KNPFE | | Bait Uniprot Accession | Q3I768 | | Bait Uniprot Identifier | Q3I768_HUMAN | | Bait Gene Name | RAB11FIP2 | | Sequence Position | 322-326 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Co-IP; Classical fluorescence spectroscopy; Y2H | | Interaction ID | 20359 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12364336, 16251358 | | Comments | Interaction between EHD1 and Rab11-FIP2 through the NPF motif (322-326) of RAB11FIP2 |
Record No : 21 |
| Instance ID | 10363 | | Regular Expression | xNPFx | | Motif Instance | TNPFT | | Bait Uniprot Accession | Q3I768 | | Bait Uniprot Identifier | Q3I768_HUMAN | | Bait Gene Name | RAB11FIP2 | | Sequence Position | 405-409 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Co-IP; Classical fluorescence spectroscopy; Pull down; Y2H | | Interaction ID | 20363 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11389591, 16251358, 12364336 | | Comments | Interaction between EHD1 and Rab11-FIP2 through the NPF motif (405-409) of RAB11FIP2 |
Record No : 22 |
| Instance ID | 10364 | | Regular Expression | xNPFx | | Motif Instance | SNPFD | | Bait Uniprot Accession | Q3I768 | | Bait Uniprot Identifier | Q3I768_HUMAN | | Bait Gene Name | RAB11FIP2 | | Sequence Position | 459-463 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR | | Interaction ID | 20364 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12364336 | | Comments | Interaction between EHD1 and Rab11-FIP2 through the NPF motif (459-463) of RAB11FIP2 |
Record No : 23 |
| Instance ID | 10369 | | Regular Expression | xNPFx | | Motif Instance | NNPFQ | | Bait Uniprot Accession | Q04206 | | Bait Uniprot Identifier | TF65_HUMAN | | Bait Gene Name | RELA | | Sequence Position | 138-142 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20369 | | Interacting Domain | EH domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15184881 | | Comments | The NPF-motif in human Transcription factor p65 (NF-kappaB subunit p65 or RELA) that acts as binding site for the EH domain in REPS2 |
Record No : 24 |
| Instance ID | 10448 | | Regular Expression | PPxxF | | Motif Instance | PPHHF | | Bait Uniprot Accession | P21817 | | Bait Uniprot Identifier | RYR1_HUMAN | | Bait Gene Name | RYR1 | | Sequence Position | 1773-1777 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Pull down; Co-IP | | Interaction ID | 20448 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12223488 | | Comments | Proline-rich motif in human Ryanodine receptor 1 that is recognized by Class II EVH1 domain of Homer1 by which Homer directly modulates the function of its target protein RyR1 and excitation-contraction coupling in skeletal myotubes |
Record No : 25 |
| Instance ID | 10480 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | IRAAIFIQKWYRRHQARREM | | Bait Uniprot Accession | P40421 | | Bait Uniprot Identifier | RDGC_DROME | | Bait Gene Name | rdgC | | Sequence Position | 6-25 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Western blot; Mutation analysis; Far Western blotting | | Interaction ID | 20480 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11754840 | | Comments | Retinal degeneration C protein or rhodopsin phosphatase encoded by the rdgC locus of Drosophila binds to Calmodulin (CaM) via its IQ motif |
Record No : 26 |
| Instance ID | 10492 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | IKKIKKVQSFMRGWLCRRKW | | Bait Uniprot Accession | P70392 | | Bait Uniprot Identifier | RGRF2_MOUSE | | Bait Gene Name | Rasgrf2 | | Sequence Position | 206-225 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 20492 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9032266 | | Comments | The Calmodulin binding IQ motif of mouse Ras guanine nucleotide exchange factor 2 (Ras-GRF2) that is required for its apparent constitutive association with calmodulin in epithelial cells ectopically expressing Ras-GRF2 |
Record No : 27 |
| Instance ID | 10615 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QGRLDGFFQV | | Bait Uniprot Accession | P26793 | | Bait Uniprot Identifier | FEN1_YEAST | | Bait Gene Name | RAD27 | | Sequence Position | 340-349 | | Critical Residues | P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20615 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10409728 | | Comments | The PCNA binding PIP box motif in Saccharomyces cerevisiae Flap endonuclease 1 (Fen1/Rad27) that mediates interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30) |
Record No : 28 |
| Instance ID | 10616 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QQTLSSFFMG | | Bait Uniprot Accession | P38766 | | Bait Uniprot Identifier | RRM3_YEAST | | Bait Gene Name | RRM3 | | Sequence Position | 35-44 | | Critical Residues | P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Y2H; Pull down | | Interaction ID | 20616 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12239216 | | Comments | The PCNA binding PIP box motif in Saccharomyces cerevisiae ATP-dependent DNA helicase RRM3 that mediates interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30) |
Record No : 29 |
| Instance ID | 10625 | | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | | Motif Instance | QKRINEFFPR | | Bait Uniprot Accession | P07276 | | Bait Uniprot Identifier | RAD2_YEAST | | Bait Gene Name | RAD2 | | Sequence Position | 995-1004 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 20625 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11545742 | | Comments | The predicted PCNA binding PIP box motif in Saccharomyces cerevisiae DNA polymerase (Pol) eta/ DNA repair protein RAD2 that may mediate interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30), which is essential for the in vivo function of Poleta |
Record No : 30 |
| Instance ID | 10641 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | EQVSAV | | Bait Uniprot Accession | Q8TEU7 | | Bait Uniprot Identifier | RPGF6_HUMAN | | Bait Gene Name | RAPGEF6 | | Sequence Position | 1596-1601 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; Competition binding; NMR | | Interaction ID | 20641 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20430886, 12095257 | | Comments | C-terminal class 1 PDZ-binding motif in human Rap guanine nucleotide exchange factor 6 (RAPGEF6) that binds to the PDZ domain of human Tyrosine-protein phosphatase non-receptor type 13 (PTPN13) |
Record No : 31 |
| Instance ID | 10647 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | TRETSL | | Bait Uniprot Accession | Q9DWF6 | | Bait Uniprot Identifier | Q9DWF6_RCMVM | | Bait Gene Name | R35 | | Sequence Position | 516-521 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Display technology | | Interaction ID | 20647 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18828675 | | Comments | C-terminal class 1 PDZ-binding motif in the R35 protein of Rat cytomegalovirus that binds to the human Scribble (SCRIB) PDZ domain |
Record No : 32 |
| Instance ID | 10692 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | LKKLRFD | | Bait Uniprot Accession | P06400 | | Bait Uniprot Identifier | RB_HUMAN | | Bait Gene Name | RB1 | | Sequence Position | 872-878 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Phosphatase assay; ITC; Mutation analysis; X-ray crystallography | | Interaction ID | 20692 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 20694007 | | Comments | An enzyme docking site in the human Retinoblastoma-associated protein (RB1/Rb) C-terminal domain that is required for association of Rb with the catalytic subunit of protein phosphatase 1 (PP1c) and efficient PP1c activity toward Rb |
Record No : 33 |
| Instance ID | 10701 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | KNRHIHFN | | Bait Uniprot Accession | Q00816 | | Bait Uniprot Identifier | REG1_YEAST | | Bait Gene Name | REG1 | | Sequence Position | 462-469 | | Critical Residues | P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20701 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10454550 | | Comments | In Saccharomyces cerevisiae, the protein phosphatase type 1 (PP1)-binding protein Reg1 interacts with the yeast PP1 homologue Glc7 through its PP1-binding site |
Record No : 34 |
| Instance ID | 10707 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | PARVRFS | | Bait Uniprot Accession | P08353 | | Bait Uniprot Identifier | ICP34_HHV1F | | Bait Gene Name | RL1 | | Sequence Position | 190-196 | | Critical Residues | P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Competition binding; Mutation analysis | | Interaction ID | 20707 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9694816 | | Comments | The PP1-binding motif in the carboxyl-terminal domain of gamma134.5 protein of herpes simplex virus 1 may bind to the catalytic subunit of protein phosphatase 1 (PPP1CA) |
Record No : 35 |
| Instance ID | 10766 | | Regular Expression | (x[^P]xNPx(Y))|(x[ILVMFY]xNxx(Y)) | | Motif Instance | WIENKLY | | Bait Uniprot Accession | P35546 | | Bait Uniprot Identifier | RET_MOUSE | | Bait Gene Name | Ret | | Sequence Position | 1057-1063 | | Critical Residues | P1; P6; P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Beta turn | | Experimental Method(s) | SPR; X-ray crystallography | | Interaction ID | 20766 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14607833 | | Comments | The N-terminal phosphotyrosine binding (PTB) domain of Mouse Dok1 can recognize and bind specifically to phosphotyrosine-containing NPxY motif of Mouse Proto-oncogene tyrosine-protein kinase receptor Ret |
Record No : 36 |
| Instance ID | 10775 | | Regular Expression | F[EDQS][MILV][ED][MILV]((x{0,1}[ED])|($)) | | Motif Instance | FDIDLD | | Bait Uniprot Accession | P23443 | | Bait Uniprot Identifier | KS6B1_HUMAN | | Bait Gene Name | RPS6KB1 | | Sequence Position | 28-33 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 20775 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11967149, 12912989 | | Comments | The TOS motif in human Ribosomal protein S6 kinase beta-1 (RPS6KB1) acts as a docking site for the human TOR pathway adaptor protein RAPTOR |
Record No : 37 |
| Instance ID | 10777 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LHCDE | | Bait Uniprot Accession | O75884 | | Bait Uniprot Identifier | RBBP9_HUMAN | | Bait Gene Name | RBBP9 | | Sequence Position | 63-67 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Co-IP | | Interaction ID | 20777 | | Interacting Domain | B domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 9697699 | | Comments | The Rb-binding LxCxE motif in the Human RBBP9/BOG that mediates binding to a highly conserved shallow groove in the B domain of the human retinoblastoma protein (RB) |
Record No : 38 |
| Instance ID | 10783 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LECEE | | Bait Uniprot Accession | Q99708 | | Bait Uniprot Identifier | COM1_HUMAN | | Bait Gene Name | RBBP8 | | Sequence Position | 153-157 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20783 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10449734 | | Comments | The Rb-binding LxCxE motif in the Human CtBP-interacting protein (CTIP)/ DNA endonuclease RBBP8 that mediates binding to a highly conserved shallow groove in the B domain of the human retinoblastoma protein (RB) |
Record No : 39 |
| Instance ID | 10786 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LVCQE | | Bait Uniprot Accession | P35251 | | Bait Uniprot Identifier | RFC1_HUMAN | | Bait Gene Name | RFC1 | | Sequence Position | 663-667 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20786 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11336696 | | Comments | The Rb-binding LxCxE motif in the Human Replication factor C large subunit (RFC1) that mediates binding to the human retinoblastoma protein (RB) and thereby promotes cell survival after DNA damage |
Record No : 40 |
| Instance ID | 10795 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LICHE | | Bait Uniprot Accession | Q8UYK9 | | Bait Uniprot Identifier | Q8UYK9_9GEMI | | Bait Gene Name | repA | | Sequence Position | 194-198 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 20795 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8623550 | | Comments | The Rb-binding LxCxE motif in the Replication-associated protein A (repA) of Wheat dwarf virus (WDV) that mediates binding to the human retinoblastoma protein (RB) |
Record No : 41 |
| Instance ID | 10804 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LRCHE | | Bait Uniprot Accession | O75150 | | Bait Uniprot Identifier | BRE1B_HUMAN | | Bait Gene Name | RNF40 | | Sequence Position | 109-113 | | Critical Residues | P1; P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20804 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10944455 | | Comments | The Rb-binding LxCxE motif in the Human E3 ubiquitin-protein ligase BRE1B/RBP95/RNF40, a novel leucine zipper protein, that mediates binding to the human retinoblastoma protein (RB) |
Record No : 42 |
| Instance ID | 10817 | | Regular Expression | x[ILVM]LGxxPx | | Motif Instance | SLLGEPPK | | Bait Uniprot Accession | Q9CW46 | | Bait Uniprot Identifier | RAVR1_MOUSE | | Bait Gene Name | Raver1 | | Sequence Position | 499-506 | | Critical Residues | P1; P2; P3; P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down; NMR | | Interaction ID | 20817 | | Interacting Domain | RRM domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16936729 | | Comments | The peptide motif (499-506) in mouse Raver1 that mediates splicing repression by interaction with the RRM2 domain of mouse Polypyrimidine tract-binding protein 2 (Ptbp2) |
Record No : 43 |
| Instance ID | 10818 | | Regular Expression | x[ILVM]LGxxPx | | Motif Instance | GLLGAPPA | | Bait Uniprot Accession | Q9CW46 | | Bait Uniprot Identifier | RAVR1_MOUSE | | Bait Gene Name | Raver1 | | Sequence Position | 360-367 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag); FRET | | Interaction ID | 20818 | | Interacting Domain | RRM domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16936729 | | Comments | The peptide motif (360-367) in mouse Raver1 that mediates splicing repression by interaction with the RRM2 domain of mouse Polypyrimidine tract-binding protein 2 (Ptbp2) |
Record No : 44 |
| Instance ID | 10819 | | Regular Expression | x[ILVM]LGxxPx | | Motif Instance | GILGDSPL | | Bait Uniprot Accession | Q9CW46 | | Bait Uniprot Identifier | RAVR1_MOUSE | | Bait Gene Name | Raver1 | | Sequence Position | 400-407 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(GST tag); FRET | | Interaction ID | 20819 | | Interacting Domain | RRM domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16936729 | | Comments | The peptide motif (400-407) in mouse Raver1 that mediates splicing repression by interaction with the RRM2 domain of mouse Polypyrimidine tract-binding protein 2 (Ptbp2) |
Record No : 45 |
| Instance ID | 10877 | | Regular Expression | [RKY]xxPxxP | | Motif Instance | YDSPCLP | | Bait Uniprot Accession | Q06609 | | Bait Uniprot Identifier | RAD51_HUMAN | | Bait Gene Name | RAD51 | | Sequence Position | 315-321 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 20877 | | Interacting Domain | SH3 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 21653319 | | Comments | Human BCR-ABL1 SH3 domain interacts with the proline-rich SH3-binding sequence of human DNA repair protein RAD51, resulting in direct phosphorylation of RAD51 on Y315, which migrates to the nucleus, and enhances formation of the nuclear foci indicative of recombination sites |
Record No : 46 |
| Instance ID | 10886 | | Regular Expression | PxxPx[KR] | | Motif Instance | PALPPK | | Bait Uniprot Accession | Q13905 | | Bait Uniprot Identifier | RPGF1_HUMAN | | Bait Gene Name | RAPGEF1 | | Sequence Position | 284-289 | | Critical Residues | P1; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20886 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7735837 | | Comments | The SH3 domain of Proto-oncogene c-Crk engages in an unusual lysine-specific interaction to bind the lysine-containing proline-rich peptide from the guanine nucleotide exchange factor C3G with high affinity |
Record No : 47 |
| Instance ID | 10969 | | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | | Motif Instance | VIDLTED | | Bait Uniprot Accession | Q9UT72 | | Bait Uniprot Identifier | RFP2_SCHPO | | Bait Gene Name | rfp2 | | Sequence Position | 19-25 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Y2H; Mutation analysis; Pull down | | Interaction ID | 20969 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17762865, 17762864 | | Comments | The N‐terminal SUMO-interacting motif (19-25) of Schizosaccharomyces pombe (Fission yeast) protein Rfp2 that mediates interactions with Pmt3, the fission yeast version of SUMO |
Record No : 48 |
| Instance ID | 10974 | | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | | Motif Instance | LLDLT | | Bait Uniprot Accession | Q9UT72 | | Bait Uniprot Identifier | RFP2_SCHPO | | Bait Gene Name | rfp2 | | Sequence Position | 38-42 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20974 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17762865 | | Comments | The N‐terminal SUMO-interacting motif (38-42) of Schizosaccharomyces pombe (Fission yeast) protein Rfp2 that mediates interactions with Pmt3, the fission yeast version of SUMO |
Record No : 49 |
| Instance ID | 10985 | | Regular Expression | [STDE]{1,10}[ILV](x[ILV]|[ILV]|[ILV]x)[ILV] | | Motif Instance | SVIDL | | Bait Uniprot Accession | O13826 | | Bait Uniprot Identifier | RFP1_SCHPO | | Bait Gene Name | rfp1 | | Sequence Position | 13-17 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Y2H; Mutation analysis; Pull down | | Interaction ID | 20985 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17762865, 17762864 | | Comments | Inverted version of the N‐terminal SUMO-interacting motif (13-17) of Schizosaccharomyces pombe (Fission yeast) protein Rfp1 that mediates interactions with Pmt3, the fission yeast version of SUMO |
Record No : 50 |
| Instance ID | 10986 | | Regular Expression | [STDE]{1,10}[ILV](x[ILV]|[ILV]|[ILV]x)[ILV] | | Motif Instance | DDDVLIV | | Bait Uniprot Accession | P49792 | | Bait Uniprot Identifier | RBP2_HUMAN | | Bait Gene Name | RANBP2 | | Sequence Position | 2629-2635 | | Critical Residues | P4; P6; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Y2H; X-ray crystallography; Pull down; Mutation analysis | | Interaction ID | 20986 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16524884, 15931224, 15388847 | | Comments | Inverted version of the SUMO-interacting motif (SIM) of human E3 SUMO-protein ligase RANBP2 that mediates specific interaction with sumoylated human Ran GTPase-activating protein 1 (RANGAP1) |
Record No : 51 |
| Instance ID | 10998 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | IRPPPDGS | | Bait Uniprot Accession | Q92698 | | Bait Uniprot Identifier | RAD54_HUMAN | | Bait Gene Name | RAD54L | | Sequence Position | 690-697 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence polarization spectroscopy; Mutation analysis; Co-IP | | Interaction ID | 20998 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22153077 | | Comments | The N-terminal region of ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif in human DNA repair and recombination protein RAD54L |
Record No : 52 |
| Instance ID | 11109 | | Regular Expression | xxx([ST])Px | | Motif Instance | SPPSPP | | Bait Uniprot Accession | P10276 | | Bait Uniprot Identifier | RARA_HUMAN | | Bait Gene Name | RARA | | Sequence Position | 74-79 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Mutation analysis; Pull down | | Interaction ID | 21109 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15670742 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Ser-77-Pro motif of human Retinoic acid receptor alpha and induces its degradation |
Record No : 53 |
| Instance ID | 11149 | | Regular Expression | xxx([ST])Px | | Motif Instance | VFRTPP | | Bait Uniprot Accession | Q04206 | | Bait Uniprot Identifier | TF65_HUMAN | | Bait Gene Name | RELA | | Sequence Position | 251-256 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Alanine scanning | | Interaction ID | 21149 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 14690596 | | Comments | Upon cytokine treatment, human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Thr-254-Pro motif in human Nuclear factor NF-kappa-B p65 subunit (RELA) and inhibits p65 binding to I-kappa-B-alpha, resulting in increased nuclear accumulation and protein stability of p65 and enhanced NF-kappa-B activity |
Record No : 54 |
| Instance ID | 11166 | | Regular Expression | xx(T)xx[ILV]x | | Motif Instance | ELTQELP | | Bait Uniprot Accession | P14737 | | Bait Uniprot Identifier | RAD9_YEAST | | Bait Gene Name | RAD9 | | Sequence Position | 601-607 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Thr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | SPR; NMR | | Interaction ID | 21166 | | Interacting Domain | FHA domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11846568 | | Comments | The FHA domain of yeast Serine/threonine-protein kinase RAD53 binds to the phosphothreonine motif from the yeast DNA repair protein RAD9 |
Record No : 55 |
| Instance ID | 11172 | | Regular Expression | xx(T)xx[DE]x | | Motif Instance | FQTPTDP | | Bait Uniprot Accession | P14737 | | Bait Uniprot Identifier | RAD9_YEAST | | Bait Gene Name | RAD9 | | Sequence Position | 153-159 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Thr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; SPR | | Interaction ID | 21172 | | Interacting Domain | FHA domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11846567 | | Comments | The FHA domain of yeast Serine/threonine-protein kinase RAD53 binds to the phosphothreonine motif (153-159) from the yeast DNA repair protein RAD9 |
Record No : 56 |
| Instance ID | 11173 | | Regular Expression | xx(T)xx[DE]x | | Motif Instance | EVTEADA | | Bait Uniprot Accession | P14737 | | Bait Uniprot Identifier | RAD9_YEAST | | Bait Gene Name | RAD9 | | Sequence Position | 190-196 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Thr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; SPR | | Interaction ID | 21173 | | Interacting Domain | FHA domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11846567 | | Comments | The FHA domain of yeast Serine/threonine-protein kinase RAD53 binds to the phosphothreonine motif (190-196) from the yeast DNA repair protein RAD9 |
Record No : 57 |
| Instance ID | 11233 | | Regular Expression | [ST]x[VL]D | | Motif Instance | TSLD | | Bait Uniprot Accession | Q96T23 | | Bait Uniprot Identifier | RSF1_HUMAN | | Bait Gene Name | RSF1 | | Sequence Position | 539-542 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21233 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22876914 | | Comments | Novel internal motif identified in human Remodeling and spacing factor 1 (RSF1) that is recognized by human Glutaminase-interacting protein (GIP), also known as Tax-interacting protein 1 (TIP1) or Tax1-binding protein 3 (TAX1BP3), composed almost exclusively of a single PDZ domain |
Record No : 58 |
| Instance ID | 11318 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | SQATQTE | | Bait Uniprot Accession | Q8IV61 | | Bait Uniprot Identifier | GRP3_HUMAN | | Bait Gene Name | RASGRP3 | | Sequence Position | 611-617 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21318 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in human Ras guanyl-releasing protein 3 (RASGRP3) that interacts with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8) |
Record No : 59 |
| Instance ID | 11319 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | SQATQTE | | Bait Uniprot Accession | Q8IV61 | | Bait Uniprot Identifier | GRP3_HUMAN | | Bait Gene Name | RASGRP3 | | Sequence Position | 611-617 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21319 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in human Ras guanyl-releasing protein 3 (RASGRP3) that interacts with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2) |
Record No : 60 |
| Instance ID | 11341 | | Regular Expression | SxxF | | Motif Instance | SPVF | | Bait Uniprot Accession | Q99708 | | Bait Uniprot Identifier | COM1_HUMAN | | Bait Gene Name | RBBP8 | | Sequence Position | 327-330 | | Critical Residues | P1; P4 | | Motif PTM(s) | Phosphorylation at Ser-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Mutational analysis; Sequence based prediction; ITC | | Interaction ID | 21341 | | Interacting Domain | BRCT domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16101277, 15485915, 14578343 | | Comments | Motif mediating phosphorylation-dependent BRCA1-CtIP interaction essential for G2/M transition checkpoint control of the cell cycle |
Record No : 61 |
| Instance ID | 11638 | | Regular Expression | L[EQ]E[FL]LG[DE] | | Motif Instance | LEEFLGD | | Bait Uniprot Accession | Q14257 | | Bait Uniprot Identifier | RCN2_HUMAN | | Bait Gene Name | RCN2 | | Sequence Position | 208-214 | | Critical Residues | P1; P4; P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21638 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9593689, 9472622 | | Comments | Consensus E6-binding sequence in E6BP or Calcium-binding protein ERC-55 (RCN2) for binding to E6 oncoprotein of Human papillomavirus type 16 |
Record No : 62 |
| Instance ID | 11639 | | Regular Expression | L[EQ]E[FL]LG[DE] | | Motif Instance | LEEFLGD | | Bait Uniprot Accession | Q14257 | | Bait Uniprot Identifier | RCN2_HUMAN | | Bait Gene Name | RCN2 | | Sequence Position | 208-214 | | Critical Residues | P1; P4; P5; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21639 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9593689 | | Comments | Consensus E6-binding sequence in E6BP or Calcium-binding protein ERC-55 (RCN2) for binding to E6 oncoprotein of Bovine Papillomavirus Type 1 |
Record No : 63 |
| Instance ID | 11653 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | Q01196 | | Bait Uniprot Identifier | RUNX1_HUMAN | | Bait Gene Name | RUNX1 | | Sequence Position | 355-358 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21653 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10228168 | | Comments | The PY motif (PPxY) in the subregion of the transcription activation domain of the DNA-binding subunit of human Runt-related transcription factor 1 (or PEBP2alpha) that mediates binding to the WW domain of human Yes-associated protein (YAP) |
Record No : 64 |
| Instance ID | 11654 | | Regular Expression | PPxY | | Motif Instance | PPPY | | Bait Uniprot Accession | Q03347 | | Bait Uniprot Identifier | RUNX1_MOUSE | | Bait Gene Name | Runx1 | | Sequence Position | 354-357 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Y2H | | Interaction ID | 21654 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11118213 | | Comments | The PPxY motif of mouse Runt-related transcription factor 1 (or PEBP2alpha) that mediates binding to the WW domain of mouse WW domain-containing transcription regulator protein 1 (or Taz) |
Record No : 65 |
| Instance ID | 11696 | | Regular Expression | [SG][IL]LGxxP | | Motif Instance | GLLGAPP | | Bait Uniprot Accession | Q9CW46 | | Bait Uniprot Identifier | RAVR1_MOUSE | | Bait Gene Name | Raver1 | | Sequence Position | 360-366 | | Critical Residues | P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag); Minigene reporter assay | | Interaction ID | 21696 | | Interacting Domain | RRM2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16936729, 19962980 | | Comments | PTB binding motif in mouse Raver1 that interacts with Polypyrimidine tract-binding protein 1 (PTB) RRM2 |
Record No : 66 |
| Instance ID | 11697 | | Regular Expression | [SG][IL]LGxxP | | Motif Instance | GILGDSP | | Bait Uniprot Accession | Q9CW46 | | Bait Uniprot Identifier | RAVR1_MOUSE | | Bait Gene Name | Raver1 | | Sequence Position | 400-406 | | Critical Residues | P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag); Minigene reporter assay | | Interaction ID | 21697 | | Interacting Domain | RRM2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16936729, 19962980 | | Comments | PTB binding motif in mouse Raver1 that interacts with Polypyrimidine tract-binding protein 1 (PTB) RRM2 |
Record No : 67 |
| Instance ID | 11698 | | Regular Expression | [SG][IL]LGxxP | | Motif Instance | SLLGEPP | | Bait Uniprot Accession | Q9CW46 | | Bait Uniprot Identifier | RAVR1_MOUSE | | Bait Gene Name | Raver1 | | Sequence Position | 499-505 | | Critical Residues | P1; P2; P3; P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | NMR; Mutational analysis; Pull down(GST tag); Minigene reporter assay | | Interaction ID | 21698 | | Interacting Domain | RRM2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16936729, 19962980 | | Comments | PTB binding motif in mouse Raver1 that interacts with Polypyrimidine tract-binding protein 1 (PTB) RRM2 |
Record No : 68 |
| Instance ID | 11699 | | Regular Expression | [SG][IL]LGxxP | | Motif Instance | GLLGEPP | | Bait Uniprot Accession | Q7TPD6 | | Bait Uniprot Identifier | RAVR2_MOUSE | | Bait Gene Name | Raver2 | | Sequence Position | 423-429 | | Critical Residues | P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21699 | | Interacting Domain | RRM2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19962980 | | Comments | PTB binding motif in mouse Raver2 that interacts with Polypyrimidine tract-binding protein 1 (PTB) RRM2 |
Record No : 69 |
| Instance ID | 11700 | | Regular Expression | [SG][IL]LGxxP | | Motif Instance | SLLGEPP | | Bait Uniprot Accession | Q7TPD6 | | Bait Uniprot Identifier | RAVR2_MOUSE | | Bait Gene Name | Raver2 | | Sequence Position | 501-507 | | Critical Residues | P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21700 | | Interacting Domain | RRM2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19962980 | | Comments | PTB binding motif in mouse Raver2 that interacts with Polypyrimidine tract-binding protein 1 (PTB) RRM2 |
Record No : 70 |
| Instance ID | 11762 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RQLPQVP | | Bait Uniprot Accession | Q86UR5 | | Bait Uniprot Identifier | RIMS1_HUMAN | | Bait Gene Name | RIMS1 | | Sequence Position | 1269-1275 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21762 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11988172, 10748113 | | Comments | The SH3 domain-binding motif in human Rab-3-interacting molecule 1 (RIMS1) that binds the SH3 domains of human RIMS-binding protein 1 (RBP1) |
Record No : 71 |
| Instance ID | 11763 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RQLPQVP | | Bait Uniprot Accession | Q86UR5 | | Bait Uniprot Identifier | RIMS1_HUMAN | | Bait Gene Name | RIMS1 | | Sequence Position | 1269-1275 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21763 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11988172, 10748113 | | Comments | The SH3 domain-binding motif in human Rab-3-interacting molecule 1 (RIMS1) that binds the SH3 domains of human RIMS-binding protein 2 (RBP2) |
Record No : 72 |
| Instance ID | 11764 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RQLPQLP | | Bait Uniprot Accession | Q9UQ26 | | Bait Uniprot Identifier | RIMS2_HUMAN | | Bait Gene Name | RIMS2 | | Sequence Position | 1160-1166 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); Competition binding assay | | Interaction ID | 21764 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11988172, 10748113 | | Comments | The SH3 domain-binding motif in human Rab-3-interacting molecule 2 (RIMS2) that binds the SH3 domains of human RIMS-binding protein 1 (RBP1) |
Record No : 73 |
| Instance ID | 11765 | | Regular Expression | [RK]xxPxxP | | Motif Instance | RQLPQLP | | Bait Uniprot Accession | Q9UQ26 | | Bait Uniprot Identifier | RIMS2_HUMAN | | Bait Gene Name | RIMS2 | | Sequence Position | 1160-1166 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); Competition binding assay | | Interaction ID | 21765 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11988172, 10748113 | | Comments | The SH3 domain-binding motif in human Rab-3-interacting molecule 2 (RIMS2) that binds the SH3 domains of human RIMS-binding protein 2 (RBP2) |
Record No : 74 |
| Instance ID | 11816 | | Regular Expression | [RK]x{0,1}[VIL][^P][FW] | | Motif Instance | RHIHF | | Bait Uniprot Accession | Q00816 | | Bait Uniprot Identifier | REG1_YEAST | | Bait Gene Name | REG1 | | Sequence Position | 464-468 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21816 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20170726 | | Comments | The RVxF motif in Reg1 protein of Saccharomyces cerevisiae that is essential for interaction with the PP1 phosphatase Glc7 |
Record No : 75 |
| Instance ID | 11817 | | Regular Expression | [RK]x{0,1}[VIL][^P][FW] | | Motif Instance | RHIHF | | Bait Uniprot Accession | Q00816 | | Bait Uniprot Identifier | REG1_YEAST | | Bait Gene Name | REG1 | | Sequence Position | 464-468 | | Critical Residues | P3; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21817 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20170726 | | Comments | The RVxF motif in Reg1 protein of Saccharomyces cerevisiae that is required for binding to the Snf1 protein kinase |
Record No : 76 |
| Instance ID | 11854 | | Regular Expression | FGPxL | | Motif Instance | FGPAL | | Bait Uniprot Accession | Q15413 | | Bait Uniprot Identifier | RYR3_HUMAN | | Bait Gene Name | RYR3 | | Sequence Position | 2228-2232 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Phage Display; SPOT Analysis | | Interaction ID | 21854 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15845542 | | Comments | The consensus motif in human Ryanodine receptor 3 that represent putative target sites for binding of Cyclophilin A, a peptidyl-prolyl cis/trans-isomerase that is involved in multiple signaling events of eukaryotic cells |
Record No : 77 |
| Instance ID | 11864 | | Regular Expression | HxPR | | Motif Instance | HFPR | | Bait Uniprot Accession | Q13127 | | Bait Uniprot Identifier | REST_HUMAN | | Bait Gene Name | REST | | Sequence Position | 270-273 | | Critical Residues | P1; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21864 | | Interacting Domain | Carboxyl-flanking region of the SPXX region | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15720400 | | Comments | CP2-binding HXPR motif of RE1-silencing transcription factor (REST) that is involved in interactions with the transcriptional factor CP2 |
Record No : 78 |
| Instance ID | 11959 | | Regular Expression | PxLPx[IL] | | Motif Instance | PPLPGL | | Bait Uniprot Accession | P48382 | | Bait Uniprot Identifier | RFX5_HUMAN | | Bait Gene Name | RFX5 | | Sequence Position | 173-178 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | ITC | | Interaction ID | 21959 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22649097 | | Comments | The PxLPxI/L motif of human DNA-binding protein RFX5 recognized by Ankyrin repeat family A protein 2 (ANKRA2) for binding to the ankyrin repeat domain |
Record No : 79 |
| Instance ID | 11962 | | Regular Expression | PxLPx[IL] | | Motif Instance | PPLPGL | | Bait Uniprot Accession | P48382 | | Bait Uniprot Identifier | RFX5_HUMAN | | Bait Gene Name | RFX5 | | Sequence Position | 173-178 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; ITC | | Interaction ID | 21962 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22649097 | | Comments | The PxLPxI/L motif of human DNA-binding protein RFX5 recognized by Regulatory factor X-associated ankyrin-containing protein (RFXANK, also known as ANKRA1 and RFX-B) for binding to the ankyrin repeat domain |
Record No : 80 |
| Instance ID | 12001 | | Regular Expression | [RK]xK[ST]Cxxx$ | | Motif Instance | KAKSCTVM | | Bait Uniprot Accession | P61587 | | Bait Uniprot Identifier | RND3_HUMAN | | Bait Gene Name | RND3 | | Sequence Position | 237-244 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4; Farnesylation at Cys-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; ITC; BLI | | Interaction ID | 22001 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23622247 | | Comments | C-terminal hybrid III/IV 14-3-3-binding motif in human Rho family GTPase 3 (RND3) that interacts with human 14-3-3 protein zeta on being phosphorylated at Ser-240 by ROCK1 |
Record No : 81 |
| Instance ID | 12002 | | Regular Expression | [RK]xK[ST]Cxxx$ | | Motif Instance | KAKSCTVM | | Bait Uniprot Accession | P61587 | | Bait Uniprot Identifier | RND3_HUMAN | | Bait Gene Name | RND3 | | Sequence Position | 237-244 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4; Farnesylation at Cys-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide Pull-Down Assay; Co-IP; Pull down(GST tag) | | Interaction ID | 22002 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23622247 | | Comments | C-terminal hybrid III/IV 14-3-3-binding motif in human Rho family GTPase 3 (RND3) that interacts with human 14-3-3 protein beta on being phosphorylated at Ser-240 by ROCK1 |
Record No : 82 |
| Instance ID | 12003 | | Regular Expression | [RK]xK[ST]Cxxx$ | | Motif Instance | KAKSCSIM | | Bait Uniprot Accession | Q92730 | | Bait Uniprot Identifier | RND1_HUMAN | | Bait Gene Name | RND1 | | Sequence Position | 225-232 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4; Farnesylation at Cys-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22003 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23622247 | | Comments | C-terminal hybrid III/IV 14-3-3-binding motif in human Rho family GTPase 1 (RND1) that interacts with human 14-3-3 protein beta on being phosphorylated at Ser-228 |
Record No : 83 |
| Instance ID | 12004 | | Regular Expression | [RK]xK[ST]Cxxx$ | | Motif Instance | RAKSCNLM | | Bait Uniprot Accession | P52198 | | Bait Uniprot Identifier | RND2_HUMAN | | Bait Gene Name | RND2 | | Sequence Position | 220-227 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4; Farnesylation at Cys-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 22004 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23622247 | | Comments | C-terminal hybrid III/IV 14-3-3-binding motif in human Rho family GTPase 2 (RND2) that interacts with human 14-3-3 protein beta on being phosphorylated at Ser-223 |
Record No : 84 |
| Instance ID | 12005 | | Regular Expression | [RK]xK[ST]Cxxx$ | | Motif Instance | KKKSCLLL | | Bait Uniprot Accession | P62834 | | Bait Uniprot Identifier | RAP1A_HUMAN | | Bait Gene Name | RAP1A | | Sequence Position | 177-184 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4; Farnesylation at Cys-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | BLI | | Interaction ID | 22005 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23622247 | | Comments | C-terminal hybrid III/IV 14-3-3-binding motif in human Ras-related protein RAP1A that interacts with human 14-3-3 protein zeta on being phosphorylated at Ser-180 |
Record No : 85 |
| Instance ID | 12041 | | Regular Expression | ExxxD | | Motif Instance | ENALD | | Bait Uniprot Accession | Q9NSD7 | | Bait Uniprot Identifier | RL3R1_HUMAN | | Bait Gene Name | RXFP3 | | Sequence Position | 141-145 | | Critical Residues | P1; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 22041 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24615237 | | Comments | The conserved negatively charged ExxxD motif in the in the extracellular domain of human Relaxin-3 receptor 1 (RXFP3) that is essential for its activation by human Relaxin-3 (RLN3) through an interaction with the highly conserved positively charged arginine residues of RLN3 |
Record No : 86 |
| Instance ID | 12042 | | Regular Expression | ExxxD | | Motif Instance | ESALD | | Bait Uniprot Accession | Q8TDU9 | | Bait Uniprot Identifier | RL3R2_HUMAN | | Bait Gene Name | RXFP4 | | Sequence Position | 100-104 | | Critical Residues | P1; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 22042 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24802387 | | Comments | The conserved negatively charged extracellular ExxxD motif of human Relaxin-3 receptor 2 (RXFP4) that is essential for its activation by human Relaxin-3 (RLN3) |
Record No : 87 |
| Instance ID | 12074 | | Regular Expression | PPxY | | Motif Instance | PPRY | | Bait Uniprot Accession | Q8WWW0 | | Bait Uniprot Identifier | RASF5_HUMAN | | Bait Gene Name | RASSF5 | | Sequence Position | 21-24 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22074 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 23538446 | | Comments | The PPXY motif of Human Ras association domain-containing protein 5 (RASSF5) that binds to the WW domains of Human E3 ubiquitin-protein ligase Itchy homolog (ITCH) thereby promoting the proteasomal degradation of RASSF5 |
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