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Total : 226 Records
Record No : 1 |
| Instance ID | 10034 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RKAVSMH | | Bait Uniprot Accession | P32418 | | Bait Uniprot Identifier | NAC1_HUMAN | | Bait Gene Name | SLC8A1 | | Sequence Position | 388-394 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20034 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16679322 | | Comments | 14-3-3 binding site in Sodium/calcium exchange protein 1 that binds to 14-3-3 protein epsilon, which may modulate their calcium extrusion activity |
Record No : 2 |
| Instance ID | 10035 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RKAVSMH | | Bait Uniprot Accession | P32418 | | Bait Uniprot Identifier | NAC1_HUMAN | | Bait Gene Name | SLC8A1 | | Sequence Position | 388-394 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20035 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16679322 | | Comments | 14-3-3 binding site in Sodium/calcium exchange protein 1 that binds to 14-3-3 protein zeta, which may modulate their calcium extrusion activity |
Record No : 3 |
| Instance ID | 10036 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RKAVSMH | | Bait Uniprot Accession | P32418 | | Bait Uniprot Identifier | NAC1_HUMAN | | Bait Gene Name | SLC8A1 | | Sequence Position | 388-394 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20036 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16679322 | | Comments | 14-3-3 binding site in Sodium/calcium exchange protein 1 that binds to 14-3-3 protein beta, which may modulate their calcium extrusion activity |
Record No : 4 |
| Instance ID | 10037 | | Regular Expression | Rxx[^P]([ST])[IVLM]x | | Motif Instance | RKAVSMH | | Bait Uniprot Accession | P32418 | | Bait Uniprot Identifier | NAC1_HUMAN | | Bait Gene Name | SLC8A1 | | Sequence Position | 388-394 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down | | Interaction ID | 20037 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16679322 | | Comments | 14-3-3 binding site in Sodium/calcium exchange protein 1 that binds to 14-3-3 protein theta, which may modulate their calcium extrusion activity |
Record No : 5 |
| Instance ID | 10041 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSNSAI | | Bait Uniprot Accession | Q8IPH9 | | Bait Uniprot Identifier | SLOB_DROME | | Bait Gene Name | Slob | | Sequence Position | 51-56 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20041 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10230800 | | Comments | 14-3-3 binding motif (pS-54) in Drosophila Slowpoke-binding protein (Slob) that binds to 14-3-3 protein zeta |
Record No : 6 |
| Instance ID | 10042 | | Regular Expression | [RHK][STALV]x([ST])x[PESRDIFTQ] | | Motif Instance | RSASSE | | Bait Uniprot Accession | Q8IPH9 | | Bait Uniprot Identifier | SLOB_DROME | | Bait Gene Name | Slob | | Sequence Position | 76-81 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20042 | | Interacting Domain | 14-3-3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10230800 | | Comments | 14-3-3 binding motif (pS-79) in Drosophila Slowpoke-binding protein (Slob) that binds to 14-3-3 protein zeta |
Record No : 7 |
| Instance ID | 10089 | | Regular Expression | [R]xx[ILVMF][ILMVF][^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATI] | | Motif Instance | REQLMESIRKGKELKQI | | Bait Uniprot Accession | Q9U1K1 | | Bait Uniprot Identifier | SPIR_DROME | | Bait Gene Name | spir | | Sequence Position | 464-480 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Sequence based prediction; Affinity chromatography technology; Electron microscopy; Pull down; Alanine scanning; NMR; Classical fluorescence spectroscopy; structure based prediction; Molecular sieving | | Interaction ID | 20089 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10556052, 15674283, 20538977 | | Comments | WH2 motif (464-480) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of Drosophila Actin-5C |
Record No : 8 |
| Instance ID | 10090 | | Regular Expression | [R]xx[ILVMF][ILMVF][^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATI] | | Motif Instance | REQLMESIRKGKELKQI | | Bait Uniprot Accession | Q9U1K1 | | Bait Uniprot Identifier | SPIR_DROME | | Bait Gene Name | spir | | Sequence Position | 464-480 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Sequence based prediction; Affinity chromatography technology; Electron microscopy; Pull down; Alanine scanning; NMR; Classical fluorescence spectroscopy; structure based prediction; Molecular sieving | | Interaction ID | 20090 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10556052, 15674283, 20538977 | | Comments | WH2 motif (464-480) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 9 |
| Instance ID | 10091 | | Regular Expression | [R]xx[ILVMF][ILMVF][^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATI] | | Motif Instance | REQLMESIRKGKELKQI | | Bait Uniprot Accession | Q9U1K1 | | Bait Uniprot Identifier | SPIR_DROME | | Bait Gene Name | spir | | Sequence Position | 464-480 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Sequence based prediction; Affinity chromatography technology; Electron microscopy; Pull down; Alanine scanning; NMR; Classical fluorescence spectroscopy; structure based prediction; Molecular sieving | | Interaction ID | 20091 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10556052, 15674283, 20538977 | | Comments | WH2 motif (464-480) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of chicken Alpha-actin-1 |
Record No : 10 |
| Instance ID | 10092 | | Regular Expression | [R]xx[ILVMF][ILMVF][^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATI] | | Motif Instance | REQLMESIRKGKELKQI | | Bait Uniprot Accession | Q9U1K1 | | Bait Uniprot Identifier | SPIR_DROME | | Bait Gene Name | spir | | Sequence Position | 464-480 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Sequence based prediction; Affinity chromatography technology; Electron microscopy; Pull down; Alanine scanning; NMR; Classical fluorescence spectroscopy; structure based prediction; Molecular sieving | | Interaction ID | 20092 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10556052, 15674283, 20538977 | | Comments | WH2 motif (464-480) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of Acanthamoeba Actin-1 |
Record No : 11 |
| Instance ID | 10102 | | Regular Expression | [^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS] | | Motif Instance | HAMILEFIRSRPPLKKA | | Bait Uniprot Accession | Q9U1K1 | | Bait Uniprot Identifier | SPIR_DROME | | Bait Gene Name | spir | | Sequence Position | 432-448 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Affinity chromatography technology; Mutation analysis; Electron microscopy; Pull down; Alanine scanning | | Interaction ID | 20102 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15674283 | | Comments | WH2 motif (432-448) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of Acanthamoeba Actin-1 |
Record No : 12 |
| Instance ID | 10103 | | Regular Expression | [^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS] | | Motif Instance | YEILMGDIRAKKYQLRKV | | Bait Uniprot Accession | Q9U1K1 | | Bait Uniprot Identifier | SPIR_DROME | | Bait Gene Name | spir | | Sequence Position | 400-417 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Sequence based prediction; Affinity chromatography technology; Electron microscopy; Pull down; Alanine scanning; Classical fluorescence spectroscopy; structure based prediction; Molecular sieving; NMR | | Interaction ID | 20103 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10556052, 15674283, 20538977 | | Comments | WH2 motif (400-417) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of Drosophila Actin-5C |
Record No : 13 |
| Instance ID | 10104 | | Regular Expression | [^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS] | | Motif Instance | YEILMGDIRAKKYQLRKV | | Bait Uniprot Accession | Q9U1K1 | | Bait Uniprot Identifier | SPIR_DROME | | Bait Gene Name | spir | | Sequence Position | 400-417 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Sequence based prediction; Affinity chromatography technology; Electron microscopy; Pull down; Alanine scanning; Classical fluorescence spectroscopy; structure based prediction; Molecular sieving; NMR | | Interaction ID | 20104 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10556052, 15674283, 20538977 | | Comments | WH2 motif (400-417) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 14 |
| Instance ID | 10105 | | Regular Expression | [^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS] | | Motif Instance | YEILMGDIRAKKYQLRKV | | Bait Uniprot Accession | Q9U1K1 | | Bait Uniprot Identifier | SPIR_DROME | | Bait Gene Name | spir | | Sequence Position | 400-417 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Sequence based prediction; Affinity chromatography technology; Electron microscopy; Pull down; Alanine scanning; Classical fluorescence spectroscopy; structure based prediction; Molecular sieving; NMR | | Interaction ID | 20105 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10556052, 15674283, 20538977 | | Comments | WH2 motif (400-417) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of chicken Alpha-actin-1 |
Record No : 15 |
| Instance ID | 10106 | | Regular Expression | [^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS] | | Motif Instance | YEILMGDIRAKKYQLRKV | | Bait Uniprot Accession | Q9U1K1 | | Bait Uniprot Identifier | SPIR_DROME | | Bait Gene Name | spir | | Sequence Position | 400-417 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Sequence based prediction; Affinity chromatography technology; Electron microscopy; Pull down; Alanine scanning; Classical fluorescence spectroscopy; structure based prediction; Molecular sieving; NMR | | Interaction ID | 20106 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10556052, 15674283, 20538977 | | Comments | WH2 motif (400-417) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of Acanthamoeba Actin-1 |
Record No : 16 |
| Instance ID | 10107 | | Regular Expression | [^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS] | | Motif Instance | WVQVIDELRRGVRLKKS | | Bait Uniprot Accession | Q9U1K1 | | Bait Uniprot Identifier | SPIR_DROME | | Bait Gene Name | spir | | Sequence Position | 370-386 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Affinity chromatography technology; Mutation analysis; Electron microscopy; Pull down; Alanine scanning | | Interaction ID | 20107 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15674283 | | Comments | WH2 motif (370-386) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of Acanthamoeba Actin-1 |
Record No : 17 |
| Instance ID | 10108 | | Regular Expression | [^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS] | | Motif Instance | AGDFLHQIRTKQFNLRRV | | Bait Uniprot Accession | Q6AWX6 | | Bait Uniprot Identifier | SCAR1_ARATH | | Bait Gene Name | SCAR1 | | Sequence Position | 757-774 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Western blot; Pull down; Sequence based prediction | | Interaction ID | 20108 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 1529676, 15534215 | | Comments | The WH2 motif in Arabidopsis protein SCAR1 that mediates its interaction with the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 18 |
| Instance ID | 10109 | | Regular Expression | [^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS] | | Motif Instance | KDSLLAQIRNKSVNLKPA | | Bait Uniprot Accession | Q5XPJ9 | | Bait Uniprot Identifier | SCAR2_ARATH | | Bait Gene Name | SCAR2 | | Sequence Position | 1336-1353 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 20109 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15534215 | | Comments | The WH2 motif in Arabidopsis protein SCAR2 that mediates its interaction with the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 19 |
| Instance ID | 10110 | | Regular Expression | [^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS] | | Motif Instance | NDSLLEIIRSKSFNLRPA | | Bait Uniprot Accession | Q5XPJ6 | | Bait Uniprot Identifier | SCAR4_ARATH | | Bait Gene Name | SCAR4 | | Sequence Position | 1106-1123 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Sequence based prediction | | Interaction ID | 20110 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15534215 | | Comments | The WH2 motif in Arabidopsis protein SCAR4 that mediates its interaction with the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 20 |
| Instance ID | 10113 | | Regular Expression | [^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS] | | Motif Instance | TGDFLQQIRTQQFNLRPV | | Bait Uniprot Accession | Q9LP46 | | Bait Uniprot Identifier | SCAR3_ARATH | | Bait Gene Name | SCAR3 | | Sequence Position | 955-972 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Sequence based prediction | | Interaction ID | 20113 | | Interacting Domain | Hydrophobic cleft formed by subdomains 1 and 3 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15534215 | | Comments | The WH2 motif in Arabidopsis protein SCAR3 that mediates its interaction with the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1 |
Record No : 21 |
| Instance ID | 10117 | | Regular Expression | Fxx[FWY][ST][FY] | | Motif Instance | FLGFSY | | Bait Uniprot Accession | O00141 | | Bait Uniprot Identifier | SGK1_HUMAN | | Bait Gene Name | SGK1 | | Sequence Position | 418-423 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Ser-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Protein kinase assay; Competition binding; Mutation analysis; SPR | | Interaction ID | 20117 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11500365 | | Comments | Phosphorylation of the hydrophobic motif of Serine/threonine-protein kinase Sgk1 promotes its interaction with the PIF-binding pocket of PDK1 |
Record No : 22 |
| Instance ID | 10118 | | Regular Expression | Fxx[FWY][ST][FY] | | Motif Instance | FVGFSY | | Bait Uniprot Accession | Q96BR1 | | Bait Uniprot Identifier | SGK3_HUMAN | | Bait Gene Name | SGK3 | | Sequence Position | 482-487 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Ser-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Protein kinase assay; Co-IP; Mutation analysis | | Interaction ID | 20118 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16790420 | | Comments | Phosphorylation of the hydrophobic motif of Serine/threonine-protein kinase Sgk3 promotes its interaction with the PIF-binding pocket of PDK1 |
Record No : 23 |
| Instance ID | 10119 | | Regular Expression | Fxx[FWY][ST][FY] | | Motif Instance | FAGFTF | | Bait Uniprot Accession | P11792 | | Bait Uniprot Identifier | SCH9_YEAST | | Bait Gene Name | SCH9 | | Sequence Position | 733-738 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Thr-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Protein kinase assay; Mutation analysis | | Interaction ID | 20119 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21531713 | | Comments | Interaction of PKH1, the yeast ortholog of mammalian PDK1, with SCH9, the yeast S6K ortholog, depends on the hydrophobic PDK1-interacting fragment (PIF) pocket in PKH1 and requires the complementary hydrophobic motif in SCH9 |
Record No : 24 |
| Instance ID | 10120 | | Regular Expression | Fxx[FWY][ST][FY] | | Motif Instance | FVGFSY | | Bait Uniprot Accession | Q9ERE3 | | Bait Uniprot Identifier | SGK3_MOUSE | | Bait Gene Name | Sgk3 | | Sequence Position | 482-487 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Ser-P5 | | Secondary Structure | Unknown | | Experimental Method(s) | Classical fluorescence spectroscopy; Protein kinase assay; Mutation analysis | | Interaction ID | 20120 | | Interacting Domain | PIF-binding pocket | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14604990 | | Comments | CISK (Sgk3) and PDK-1 interact in a phosphorylation-dependent manner through the hydrophobic motif of Sgk3 and the PIF-binding pocket of PDK1 |
Record No : 25 |
| Instance ID | 10131 | | Regular Expression | FxDxF | | Motif Instance | FGDAF | | Bait Uniprot Accession | Q61548 | | Bait Uniprot Identifier | AP180_MOUSE | | Bait Gene Name | Snap91 | | Sequence Position | 640-644 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Co-IP; Pull down(GST tag) | | Interaction ID | 20131 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10428863, 12057195 | | Comments | The FxDxF motif responsible for the binding of mouse Clathrin coat assembly protein AP180 to the alpha-subunit of adaptor protein AP-2 and its recruitment to the site of clathrin coated vesicle formation |
Record No : 26 |
| Instance ID | 10139 | | Regular Expression | DP[FW] | | Motif Instance | DPF | | Bait Uniprot Accession | Q05140 | | Bait Uniprot Identifier | AP180_RAT | | Bait Gene Name | Snap91 | | Sequence Position | 400-402 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Far Western blotting; Mutation analysis | | Interaction ID | 20139 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10380931, 10944104 | | Comments | The DPF/W motif (400-402) of rat Clathrin coat assembly protein AP180 that binds the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 27 |
| Instance ID | 10140 | | Regular Expression | DP[FW] | | Motif Instance | DPF | | Bait Uniprot Accession | Q05140 | | Bait Uniprot Identifier | AP180_RAT | | Bait Gene Name | Snap91 | | Sequence Position | 474-476 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Far Western blotting; Mutation analysis | | Interaction ID | 20140 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-2 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10380931, 10944104 | | Comments | The DPF/W motif (474-476) of rat Clathrin coat assembly protein AP180 that binds the C-terminal appendage domain of mouse Alpha-adaptin C |
Record No : 28 |
| Instance ID | 10153 | | Regular Expression | DP[FW] | | Motif Instance | DPF | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Sequence Position | 1323-1325 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down(GST tag) | | Interaction ID | 20153 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha-1 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10801423 | | Comments | Characteristic DPF repeat (1323-1325) in the COOH-terminal domain of human Synaptojanin 1 binds specifically to the C-terminal appendage domain of human Alpha-adaptin C |
Record No : 29 |
| Instance ID | 10154 | | Regular Expression | DP[FW] | | Motif Instance | DPF | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Sequence Position | 1555-1557 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down(GST tag) | | Interaction ID | 20154 | | Interacting Domain | C-terminal appendage domain of AP-2 subunit alpha0 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10801423 | | Comments | Characteristic DPF repeat (1555-1557) in the COOH-terminal domain of human Synaptojanin 1 binds specifically to the C-terminal appendage domain of human Alpha-adaptin C |
Record No : 30 |
| Instance ID | 10159 | | Regular Expression | xRxxLxx[LIVM]x | | Motif Instance | HRKHLQEIP | | Bait Uniprot Accession | Q13309 | | Bait Uniprot Identifier | SKP2_HUMAN | | Bait Gene Name | SKP2 | | Sequence Position | 2-10 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Radiolabel; Mutation analysis | | Interaction ID | 20159 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15014503 | | Comments | The APCC-binding Destruction motif (DBox) due to which the human F-box protein Skp2 is polyubiquitinated, and hence earmarked for destruction, by APC(CDH1) |
Record No : 31 |
| Instance ID | 10201 | | Regular Expression | [DE][DES][DEGAS]F[SGAD][DEAP][LVIMFD] | | Motif Instance | DDDFADF | | Bait Uniprot Accession | Q9UMZ2 | | Bait Uniprot Identifier | SYNRG_HUMAN | | Bait Gene Name | SYNRG | | Sequence Position | 773-779 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down; Co-IP; Y2H; Classical fluorescence spectroscopy; Colocalization | | Interaction ID | 20201 | | Interacting Domain | Gamma adaptin ear (GAE) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12483220, 10477754 | | Comments | Gamma-adaptin ear interaction motif in human Gamma-synergin through which it interacts with Gamma-adaptin |
Record No : 32 |
| Instance ID | 10209 | | Regular Expression | ^M{0,1}Ax[AP]x | | Motif Instance | MAIPF | | Bait Uniprot Accession | Q9VVP8 | | Bait Uniprot Identifier | Q9VVP8_DROME | | Bait Gene Name | skl | | Sequence Position | 1-5 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Pull down; Mutation analysis | | Interaction ID | 20209 | | Interacting Domain | BIR domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11818063 | | Comments | IAP-binding motif in Drosophila IAP-inhibitory protein Sickle that binds to the BIR2 domain of Drosophila Iap2 (dIAP2) |
Record No : 33 |
| Instance ID | 10228 | | Regular Expression | xW[RK][DE]GCY$ | | Motif Instance | SWKDGCY | | Bait Uniprot Accession | Q9P270 | | Bait Uniprot Identifier | SLAI2_HUMAN | | Bait Gene Name | SLAIN2 | | Sequence Position | 575-581 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP; ITC; X-ray crystallography | | Interaction ID | 20228 | | Interacting Domain | CAP-Gly domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21646404 | | Comments | The C-Terminal acidic tail of SLAIN2 that is important for the interaction with CLIP-170 in cells |
Record No : 34 |
| Instance ID | 10229 | | Regular Expression | L[IVLMF]x[IVLMF][DE] | | Motif Instance | LLGLD | | Bait Uniprot Accession | Q91VZ6 | | Bait Uniprot Identifier | SMAP1_MOUSE | | Bait Gene Name | Smap1 | | Sequence Position | 192-196 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Mutation analysis; Alanine scanning | | Interaction ID | 20229 | | Interacting Domain | Clathrin propeller repeat | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15659652 | | Comments | Clathrin-box-like sequence in the mouse Smap1 protein that interact with the N-terminal beta-propeller structure of Clathrin heavy chain |
Record No : 35 |
| Instance ID | 10243 | | Regular Expression | [DE][DE]xxxVP[DE] | | Motif Instance | EEHFLVPD | | Bait Uniprot Accession | Q9SID1 | | Bait Uniprot Identifier | STH_ARATH | | Bait Gene Name | STH | | Sequence Position | 229-236 | | Critical Residues | P6; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20243 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11226162 | | Comments | A consensus COP1 binding motif in Arabidopsis Salt tolerance-like protein (STH) that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1 |
Record No : 36 |
| Instance ID | 10256 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | RKLTDFYPVRRS | | Bait Uniprot Accession | Q9NQR1 | | Bait Uniprot Identifier | SETD8_HUMAN | | Bait Gene Name | SETD8 | | Sequence Position | 220-231 | | Critical Residues | P6; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | RNA interference;Western blot; Co-IP; Alanine scanning; Fluorescence technology; Mutation disrupting interaction; Ubiquitinase assay | | Interaction ID | 20256 | | Interacting Domain | PCNA, C-terminal domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20932472, 21220508 | | Comments | CDT2-mediated destruction of the histone methyltransferase SETD8 prevents premature chromatin compaction in S phase |
Record No : 37 |
| Instance ID | 10257 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | RKLTDFYPVRRS | | Bait Uniprot Accession | Q9NQR1 | | Bait Uniprot Identifier | SETD8_HUMAN | | Bait Gene Name | SETD8 | | Sequence Position | 220-231 | | Critical Residues | P6; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | RNA interference;Western blot; Co-IP; Alanine scanning; Fluorescence technology; Mutation disrupting interaction; Ubiquitinase assay | | Interaction ID | 20257 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20932472, 21220508 | | Comments | CDT2-mediated destruction of the histone methyltransferase SETD8 prevents premature chromatin compaction in S phase |
Record No : 38 |
| Instance ID | 10267 | | Regular Expression | ([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR]))) | | Motif Instance | PLNLS | | Bait Uniprot Accession | P35712 | | Bait Uniprot Identifier | SOX6_HUMAN | | Bait Gene Name | SOX6 | | Sequence Position | 424-428 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20267 | | Interacting Domain | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11504872 | | Comments | The PxDLS motif in human transcription factor SOX-6 that serves as the site for interaction with the transcriptional corepressor CtBP |
Record No : 39 |
| Instance ID | 10305 | | Regular Expression | [^P]x[KR]xTQT | | Motif Instance | YTKQTQT | | Bait Uniprot Accession | Q24246 | | Bait Uniprot Identifier | DYIN_DROME | | Bait Gene Name | sw | | Sequence Position | 128-134 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; NMR | | Interaction ID | 20305 | | Interacting Domain | Dynein light chain type 1 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17570393 | | Comments | KxTQT-motif in Drosophila Cytoplasmic dynein 1 intermediate chain/ Protein short wing (sw) that binds to Drosophila LC8 (ctp) |
Record No : 40 |
| Instance ID | 10307 | | Regular Expression | [^P]x[KR]xTQT | | Motif Instance | SAKATQT | | Bait Uniprot Accession | P40688 | | Bait Uniprot Identifier | SWA_DROME | | Bait Gene Name | swa | | Sequence Position | 289-295 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Y2H; Co-IP; Pull down; Western blot; X-ray crystallography; NMR | | Interaction ID | 20307 | | Interacting Domain | Dynein light chain type 1 | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11148209, 10783235, 17570393 | | Comments | KxTQT-motif in Drosophila Protein swallow (swa) that binds to Drosophila LC8 (ctp) |
Record No : 41 |
| Instance ID | 10320 | | Regular Expression | xNPFx | | Motif Instance | ANPFP | | Bait Uniprot Accession | Q62910 | | Bait Uniprot Identifier | SYNJ1_RAT | | Bait Gene Name | Synj1 | | Sequence Position | 1400-1404 | | Critical Residues | P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Pull down; Far Western blotting | | Interaction ID | 20320 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9535728, 9428629 | | Comments | EH domain-dependent interaction between rat Eps15 and the 170 kDa isoform of endocytic protein Synaptojanin 1 mediated by the NPF motif (1400-1404) in the COOH-terminal region of Synaptojanin 1 |
Record No : 42 |
| Instance ID | 10322 | | Regular Expression | xNPFx | | Motif Instance | GNPFR | | Bait Uniprot Accession | Q62910 | | Bait Uniprot Identifier | SYNJ1_RAT | | Bait Gene Name | Synj1 | | Sequence Position | 1420-1424 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Far Western blotting; Competition binding; NMR; Pull down | | Interaction ID | 20322 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9535728, 9428629, 10757979 | | Comments | EH domain-dependent interaction between rat Eps15 and the 170 kDa isoform of endocytic protein Synaptojanin 1 mediated by the NPF motif (1420-1424) in the COOH-terminal region of Synaptojanin 1 |
Record No : 43 |
| Instance ID | 10331 | | Regular Expression | xNPFx | | Motif Instance | RNPFT | | Bait Uniprot Accession | Q62910 | | Bait Uniprot Identifier | SYNJ1_RAT | | Bait Gene Name | Synj1 | | Sequence Position | 1409-1413 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Pull down; Far Western blotting | | Interaction ID | 20331 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9535728, 9428629 | | Comments | EH domain-dependent interaction between rat Eps15 and the 170 kDa isoform of endocytic protein Synaptojanin 1 mediated by the NPF motif (1409-1413) in the COOH-terminal region of Synaptojanin 1 |
Record No : 44 |
| Instance ID | 10342 | | Regular Expression | xNPFx | | Motif Instance | SNPFA | | Bait Uniprot Accession | P56603 | | Bait Uniprot Identifier | SCAM1_RAT | | Bait Gene Name | Scamp1 | | Sequence Position | 6-10 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Y2H | | Interaction ID | 20342 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10777571 | | Comments | N-terminal NPF motif (6-10) of rat Secretory carrier membrane protein 1 (Scamp1) that interact with EH domain of Intersectin-1 |
Record No : 45 |
| Instance ID | 10346 | | Regular Expression | xNPFx | | Motif Instance | NNPFK | | Bait Uniprot Accession | P56603 | | Bait Uniprot Identifier | SCAM1_RAT | | Bait Gene Name | Scamp1 | | Sequence Position | 15-19 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Y2H | | Interaction ID | 20346 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10777571 | | Comments | N-terminal NPF motif (15-19) of rat Secretory carrier membrane protein 1 (Scamp1) that interact with EH domain of Intersectin-1 |
Record No : 46 |
| Instance ID | 10348 | | Regular Expression | xNPFx | | Motif Instance | YNPFS | | Bait Uniprot Accession | P56603 | | Bait Uniprot Identifier | SCAM1_RAT | | Bait Gene Name | Scamp1 | | Sequence Position | 37-41 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Y2H | | Interaction ID | 20348 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10777571 | | Comments | N-terminal NPF motif (37-41) of rat Secretory carrier membrane protein 1 (Scamp1) that interact with EH domain of Intersectin-1 |
Record No : 47 |
| Instance ID | 10351 | | Regular Expression | xNPFx | | Motif Instance | TNPFL | | Bait Uniprot Accession | Q8WXE9 | | Bait Uniprot Identifier | STON2_HUMAN | | Bait Gene Name | STON2 | | Sequence Position | 312-316 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; NMR; Co-IP; Pull down; ITC; Y2H | | Interaction ID | 20351 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11381094, 18200045, 14726597 | | Comments | NPF motif (312-316) of human Stonin-2 (STON2) that interacts with the endocytic machinery protein EPS15 |
Record No : 48 |
| Instance ID | 10352 | | Regular Expression | xNPFx | | Motif Instance | INPFS | | Bait Uniprot Accession | Q8WXE9 | | Bait Uniprot Identifier | STON2_HUMAN | | Bait Gene Name | STON2 | | Sequence Position | 328-332 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; NMR; Co-IP; Pull down; ITC; Y2H | | Interaction ID | 20352 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14726597, 18200045, 11381094 | | Comments | NPF motif (328-332) of human Stonin-2 (STON2) that interacts with the endocytic machinery protein EPS15 |
Record No : 49 |
| Instance ID | 10371 | | Regular Expression | xNPFx | | Motif Instance | YNPFD | | Bait Uniprot Accession | Q9Z2P6 | | Bait Uniprot Identifier | SNP29_RAT | | Bait Gene Name | Snap29 | | Sequence Position | 8-12 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down(His tag); Pull down(GST tag); Co-IP | | Interaction ID | 20371 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15371016 | | Comments | EH domain-containing protein 1 associates with rat Synaptosomal-associated protein 29 (Snap29) via EH domain/NPF interactions through the NPF motif of Snap29 |
Record No : 50 |
| Instance ID | 10394 | | Regular Expression | xNPFx | | Motif Instance | ANPFL | | Bait Uniprot Accession | Q24212 | | Bait Uniprot Identifier | STNB_DROME | | Bait Gene Name | stnB | | Sequence Position | 2-6 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Far Western blotting | | Interaction ID | 20394 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15631619 | | Comments | The NPF motif (2-6) in Drosophila stoned-B protein (stnB) that has been found to be high-affinity binding motif for the EH domain of DAP-160 (intersectin) |
Record No : 51 |
| Instance ID | 10395 | | Regular Expression | xNPFx | | Motif Instance | ANPFL | | Bait Uniprot Accession | Q24212 | | Bait Uniprot Identifier | STNB_DROME | | Bait Gene Name | stnB | | Sequence Position | 18-22 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Far Western blotting | | Interaction ID | 20395 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15631619 | | Comments | The NPF motif (18-22) in Drosophila stoned-B protein (stnB) that has been found to be high-affinity binding motif for the EH domain of DAP-160 (intersectin) |
Record No : 52 |
| Instance ID | 10396 | | Regular Expression | xNPFx | | Motif Instance | DNPFM | | Bait Uniprot Accession | Q24212 | | Bait Uniprot Identifier | STNB_DROME | | Bait Gene Name | stnB | | Sequence Position | 32-36 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Far Western blotting | | Interaction ID | 20396 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15631619 | | Comments | The NPF motif (32-36) in Drosophila stoned-B protein (stnB) that has been found to be high-affinity binding motif for the EH domain of DAP-160 (intersectin) |
Record No : 53 |
| Instance ID | 10397 | | Regular Expression | xNPFx | | Motif Instance | SNPFA | | Bait Uniprot Accession | Q24212 | | Bait Uniprot Identifier | STNB_DROME | | Bait Gene Name | stnB | | Sequence Position | 42-46 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Far Western blotting | | Interaction ID | 20397 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15631619 | | Comments | The NPF motif (42-46) in Drosophila stoned-B protein (stnB) that has been found to be high-affinity binding motif for the EH domain of DAP-160 (intersectin) |
Record No : 54 |
| Instance ID | 10398 | | Regular Expression | xNPFx | | Motif Instance | DNPFA | | Bait Uniprot Accession | Q24212 | | Bait Uniprot Identifier | STNB_DROME | | Bait Gene Name | stnB | | Sequence Position | 209-213 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Far Western blotting | | Interaction ID | 20398 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15631619 | | Comments | The NPF motif (209-213) in Drosophila stoned-B protein (stnB) that has been found to be high-affinity binding motif for the EH domain of DAP-160 (intersectin) |
Record No : 55 |
| Instance ID | 10399 | | Regular Expression | xNPFx | | Motif Instance | ANPFA | | Bait Uniprot Accession | Q24212 | | Bait Uniprot Identifier | STNB_DROME | | Bait Gene Name | stnB | | Sequence Position | 492-496 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Far Western blotting | | Interaction ID | 20399 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15631619 | | Comments | The NPF motif (492-496) in Drosophila stoned-B protein (stnB) that has been found to be high-affinity binding motif for the EH domain of DAP-160 (intersectin) |
Record No : 56 |
| Instance ID | 10400 | | Regular Expression | xNPFx | | Motif Instance | VNPFE | | Bait Uniprot Accession | Q24212 | | Bait Uniprot Identifier | STNB_DROME | | Bait Gene Name | stnB | | Sequence Position | 672-676 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Far Western blotting | | Interaction ID | 20400 | | Interacting Domain | EH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15631619 | | Comments | The NPF motif (672-676) in Drosophila stoned-B protein (stnB) that has been found to be high-affinity binding motif for the EH domain of DAP-160 (intersectin) |
Record No : 57 |
| Instance ID | 10449 | | Regular Expression | PPxxF | | Motif Instance | PPEEF | | Bait Uniprot Accession | Q9JLU4 | | Bait Uniprot Identifier | SHAN3_RAT | | Bait Gene Name | Shank3 | | Sequence Position | 1385-1389 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Pull down; Co-IP | | Interaction ID | 20449 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10433269 | | Comments | Proline-rich motif (1385-1389) in rat Shank3 that is recognized by Class II EVH1 domain of Homer1 |
Record No : 58 |
| Instance ID | 10450 | | Regular Expression | PPxxF | | Motif Instance | PPPTF | | Bait Uniprot Accession | Q9JLU4 | | Bait Uniprot Identifier | SHAN3_RAT | | Bait Gene Name | Shank3 | | Sequence Position | 908-912 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Pull down; Co-IP | | Interaction ID | 20450 | | Interacting Domain | WH1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10433269 | | Comments | Proline-rich motif (908-912) in rat Shank3 that is recognized by Class II EVH1 domain of Homer1 |
Record No : 59 |
| Instance ID | 10471 | | Regular Expression | P[MVLIRWY]V[MVLIAS][LM] | | Motif Instance | PVVMM | | Bait Uniprot Accession | P20193 | | Bait Uniprot Identifier | SUV37_DROME | | Bait Gene Name | Su(var)3-7 | | Sequence Position | 394-398 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Classical fluorescence spectroscopy | | Interaction ID | 20471 | | Interacting Domain | Chromo shadow domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12163401 | | Comments | The PxVxL HP1-binding motif found in the Drosophila protein Suppressor of variegation 3-7 [Su(var)3-7] that interacts with a chomoshadow domain dimer of the heterochromatin protein 1 (HP1) |
Record No : 60 |
| Instance ID | 10474 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | EVSAIVIQRAYRRYLLKQKV | | Bait Uniprot Accession | P04775 | | Bait Uniprot Identifier | SCN2A_RAT | | Bait Gene Name | Scn2a | | Sequence Position | 1906-1925 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Fluorescence polarization spectroscopy; NMR | | Interaction ID | 20474 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21439835 | | Comments | The Calmodulin binding IQ motif of the rat Na(V)1.2 voltage-dependent sodium channel (Scn2a) that binds to the apo C-domain of Paramecium Calmodulin (CaM) |
Record No : 61 |
| Instance ID | 10494 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | EVSAVVLQRAYRGHLARRGF | | Bait Uniprot Accession | Q9WTU3 | | Bait Uniprot Identifier | SCN8A_MOUSE | | Bait Gene Name | Scn8a | | Sequence Position | 1894-1913 | | Critical Residues | P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 20494 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12967988 | | Comments | Bovine Calmodulin binds to the C terminus of mouse Voltage-gated sodium channel subunit alpha Nav1.6 |
Record No : 62 |
| Instance ID | 10495 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | EVCAIKIQRAYRRHLLQRSV | | Bait Uniprot Accession | P15390 | | Bait Uniprot Identifier | SCN4A_RAT | | Bait Gene Name | Scn4a | | Sequence Position | 1721-1740 | | Critical Residues | P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; Co-IP; Pull down(GST tag) | | Interaction ID | 20495 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12967988 | | Comments | Bovine Calmodulin binds to the C terminus of rat Voltage-gated sodium channel subunit alpha Nav1.4 |
Record No : 63 |
| Instance ID | 10496 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | EVSAMVIQRAFRRHLLQRSL | | Bait Uniprot Accession | Q14524 | | Bait Uniprot Identifier | SCN5A_HUMAN | | Bait Gene Name | SCN5A | | Sequence Position | 1902-1921 | | Critical Residues | P7; P8; P9; P11; P12 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Fluorescence technology; Co-IP; Mutation analysis; NMR; Alanine scanning | | Interaction ID | 20496 | | Interacting Domain | EF hand | | Disease Association(s) | Brugada syndrome; Long QT syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 16505387, 21167176 | | Comments | The ubiquitous calcium sensor protein calmodulin (CaM) binds to the human voltage-gated sodium channel NaV1.5 IQ motif |
Record No : 64 |
| Instance ID | 10508 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | CVILPEIQKPERKIQFKEK | | Bait Uniprot Accession | P38377 | | Bait Uniprot Identifier | S61A1_CANFA | | Bait Gene Name | SEC61A1 | | Sequence Position | 13-31 | | Critical Residues | P12 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Fluorescence correlation spectroscopy; Peptide‐spot binding assay; Alanine scanning | | Interaction ID | 20508 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21102557 | | Comments | The Calmodulin binding IQ motif in the cytosolic N-terminus of Protein transport protein Sec61 alpha-1 of Canis lupus familiaris that bound CaM but not Ca2+-free apocalmodulin with nanomolar affinity and sequence specificity |
Record No : 65 |
| Instance ID | 10509 | | Regular Expression | xxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx | | Motif Instance | EVSAVIIQRAYRRHLLKRTV | | Bait Uniprot Accession | P04774 | | Bait Uniprot Identifier | SCN1A_RAT | | Bait Gene Name | Scn1a | | Sequence Position | 1916-1935 | | Critical Residues | P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Pull down; Co-IP; Mutation analysis | | Interaction ID | 20509 | | Interacting Domain | EF hand | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21726526 | | Comments | The ubiquitous calcium sensor calmodulin (CaM) binds to the IQ Motif of rat brain Voltage-gated sodium channel subunit alpha Nav1.1 |
Record No : 66 |
| Instance ID | 10521 | | Regular Expression | [KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF] | | Motif Instance | RRNLKGLNLNL | | Bait Uniprot Accession | P06784 | | Bait Uniprot Identifier | STE7_YEAST | | Bait Gene Name | STE7 | | Sequence Position | 9-19 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Pull down; Fluorescence polarization spectroscopy | | Interaction ID | 20521 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16364919 | | Comments | Saccharomyces cerevisiae MAPK kinase Ste7 docking motif 1 (9-19) that selectively binds the yeast Mitogen-activated protein kinase FUS3 |
Record No : 67 |
| Instance ID | 10530 | | Regular Expression | [KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF] | | Motif Instance | RRGIKKKLTL | | Bait Uniprot Accession | P06784 | | Bait Uniprot Identifier | STE7_YEAST | | Bait Gene Name | STE7 | | Sequence Position | 62-71 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Competition Fluorescence Polarization Binding Assay | | Interaction ID | 20530 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16364919 | | Comments | Saccharomyces cerevisiae MAPK kinase Ste7 docking motif 2 (62-71) that selectively binds the yeast Mitogen-activated protein kinase FUS3 |
Record No : 68 |
| Instance ID | 10536 | | Regular Expression | FxFP | | Motif Instance | FPFP | | Bait Uniprot Accession | Q9R1Z8 | | Bait Uniprot Identifier | VINEX_MOUSE | | Bait Gene Name | Sorbs3 | | Sequence Position | 630-633 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20536 | | Interacting Domain | Protein kinase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15184391 | | Comments | The FXFP motif in mouse Vinexin (Sorbs3) that mediates binding to mouse MAP kinase 1 (or ERK-2) |
Record No : 69 |
| Instance ID | 10649 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | LMETDV | | Bait Uniprot Accession | Q9Q8T6 | | Bait Uniprot Identifier | Q9Q8T6_RFVKA | | Bait Gene Name | s147R | | Sequence Position | 282-287 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Display technology | | Interaction ID | 20649 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18828675 | | Comments | C-terminal class 1 PDZ-binding motif in the Gp147R protein of Rabbit fibroma virus that binds to the human Scribble (SCRIB) PDZ domain |
Record No : 70 |
| Instance ID | 10661 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | VQQTRV | | Bait Uniprot Accession | Q9QUH6 | | Bait Uniprot Identifier | SYGP1_RAT | | Bait Gene Name | Syngap1 | | Sequence Position | 1303-1308 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Co-IP; Competition binding; Y2H | | Interaction ID | 20661 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9581761 | | Comments | C-terminal class 1 PDZ-binding motif in rat Ras-GTPase activating protein, Syngap1 that binds to the PDZ domain of rat Dlg4 or Psd95 |
Record No : 71 |
| Instance ID | 10662 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | VQQTRV | | Bait Uniprot Accession | Q9QUH6 | | Bait Uniprot Identifier | SYGP1_RAT | | Bait Gene Name | Syngap1 | | Sequence Position | 1303-1308 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Co-IP; Competition binding; Y2H | | Interaction ID | 20662 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9581761 | | Comments | C-terminal class 1 PDZ-binding motif in rat Ras-GTPase activating protein, Syngap1 that binds to the PDZ domain of rat Dlg3 or SAP-102 |
Record No : 72 |
| Instance ID | 10670 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | ASGSSV | | Bait Uniprot Accession | O55207 | | Bait Uniprot Identifier | SYNJ2_RAT | | Bait Gene Name | Synj2 | | Sequence Position | 1288-1293 | | Critical Residues | P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Peptide binding to perpetrator | | Interaction ID | 20670 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10357812 | | Comments | Class 1 PDZ domain-binding motif in Isoform 7.5kb of mouse Synaptojanin-2 (Synj2) that binds to the PDZ domain of mouse Synaptojanin-2-binding protein (Synj2bp)/ Mitochondrial outer membrane protein 25 (Omp25) |
Record No : 73 |
| Instance ID | 10680 | | Regular Expression | xxx[VLIFY]x[ACVILF]$ | | Motif Instance | TNEFYA | | Bait Uniprot Accession | P31431 | | Bait Uniprot Identifier | SDC4_HUMAN | | Bait Gene Name | SDC4 | | Sequence Position | 193-198 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | ITC; X-ray crystallography | | Interaction ID | 20680 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12679023, 16533050, 12842047 | | Comments | The C-terminal class 2 PDZ-binding motif of human Syndecan-4 (SDC4) that binds to the PDZ domain of human Syntenin-1 (SDCBP) |
Record No : 74 |
| Instance ID | 10683 | | Regular Expression | xxx[VLIFY]x[ACVILF]$ | | Motif Instance | QEEFYA | | Bait Uniprot Accession | P18827 | | Bait Uniprot Identifier | SDC1_HUMAN | | Bait Gene Name | SDC1 | | Sequence Position | 305-310 | | Critical Residues | P5 | | Motif PTM(s) | Phosphorylation at Tyr-P5 | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 20683 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19228696 | | Comments | The C-terminal class 2 PDZ-binding motif of human Syndecan-1 (SDC1) that binds to the PDZ domain of human Syntenin-1 (SDCBP) on dephosphorylation of Tyr-309 |
Record No : 75 |
| Instance ID | 10698 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | DQKVDFD | | Bait Uniprot Accession | P34758 | | Bait Uniprot Identifier | SCD5_YEAST | | Bait Gene Name | SCD5 | | Sequence Position | 238-244 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Western blot | | Interaction ID | 20698 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12356757 | | Comments | Scd5p, a protein important for endocytosis and actin organization in yeast, interacts with Glc7p, a yeast Ser/Thr-specific protein phosphatase-1 (PP1), through the potential PP1-binding site at amino acids 238-244 of SCD5 |
Record No : 76 |
| Instance ID | 10699 | | Regular Expression | xx[RK]x{0,1}[VIL][^P][FW]x | | Motif Instance | SKKVRFS | | Bait Uniprot Accession | P34758 | | Bait Uniprot Identifier | SCD5_YEAST | | Bait Gene Name | SCD5 | | Sequence Position | 271-277 | | Critical Residues | P4; P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Western blot | | Interaction ID | 20699 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12356757 | | Comments | Scd5p, a protein important for endocytosis and actin organization in yeast, interacts with Glc7p, a yeast Ser/Thr-specific protein phosphatase-1 (PP1), through the potential PP1-binding site at amino acids 271-277 of SCD5 |
Record No : 77 |
| Instance ID | 10713 | | Regular Expression | xP[^P]I[^P][IV][^P] | | Motif Instance | VPNIYIQ | | Bait Uniprot Accession | P40485 | | Bait Uniprot Identifier | SLM1_YEAST | | Bait Gene Name | SLM1 | | Sequence Position | 672-678 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H; Phosphatase assay | | Interaction ID | 20713 | | Interacting Domain | Calcineurin-like phosphoesterase domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16738335 | | Comments | In Saccharomyces cerevisiae, Ca2+/calmodulin-dependent phosphatase calcineurin dephosphorylates TORC2 effector protein SLM1 and interacts with it through the calcineurin docking motif in SLM1 |
Record No : 78 |
| Instance ID | 10728 | | Regular Expression | xP[TS]APx | | Motif Instance | PPSAPS | | Bait Uniprot Accession | O14828 | | Bait Uniprot Identifier | SCAM3_HUMAN | | Bait Gene Name | SCAMP3 | | Sequence Position | 63-68 | | Critical Residues | P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPR; Mutation analysis | | Interaction ID | 20728 | | Interacting Domain | UEV domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19158374 | | Comments | Human Secretory carrier-associated membrane protein SCAMP3 localizes in part to early endosomes and negatively regulates EGFR degradation through processes that involve its ubiquitylation and interactions with the UEV domain of human ESCRT-I complex subunit TSG101 |
Record No : 79 |
| Instance ID | 10731 | | Regular Expression | xP[TS]APx | | Motif Instance | APSAPM | | Bait Uniprot Accession | P08363 | | Bait Uniprot Identifier | VP8_BTV10 | | Bait Gene Name | S10 | | Sequence Position | 40-45 | | Critical Residues | P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Confocal microscopy; Pull down; Mutation analysis | | Interaction ID | 20731 | | Interacting Domain | UEV domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16352570 | | Comments | The UEV Domain binding P[TS]AP motif in Non-structural protein NS3 of Bluetongue virus 10 that mediates binding to the UEV domain of human ESCRT-I complex subunit TSG101 |
Record No : 80 |
| Instance ID | 10753 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | VFTNAAFD | | Bait Uniprot Accession | P16109 | | Bait Uniprot Identifier | LYAM3_HUMAN | | Bait Gene Name | SELP | | Sequence Position | 820-827 | | Critical Residues | P2; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis; Y2H; SPR | | Interaction ID | 20753 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19138666 | | Comments | The N-terminal phosphotyrosine-binding (PTB) domain of Human Numb3 (NUMB) binds to the cytosolic tail of the leukocyte adhesion receptor P-selectin (SELP) |
Record No : 81 |
| Instance ID | 10756 | | Regular Expression | (x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x) | | Motif Instance | SVPNPVFG | | Bait Uniprot Accession | Q9NY15 | | Bait Uniprot Identifier | STAB1_HUMAN | | Bait Gene Name | STAB1 | | Sequence Position | 2536-2543 | | Critical Residues | P4; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Pull down; Alanine scanning | | Interaction ID | 20756 | | Interacting Domain | PTB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20599701 | | Comments | The PTB domain of human adapter protein GULP is able to specifically interact with the NPxF/Y motif of human phagocytic receptor Stabilin-1 (STAB1) cytoplasmic region thus functioning as an adaptor protein for Stabilin-1-mediated phagocytosis |
Record No : 82 |
| Instance ID | 10790 | | Regular Expression | [LI]xCx[DE] | | Motif Instance | LTCEE | | Bait Uniprot Accession | P51531 | | Bait Uniprot Identifier | SMCA2_HUMAN | | Bait Gene Name | SMARCA2 | | Sequence Position | 1294-1298 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20790 | | Interacting Domain | B domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9326598 | | Comments | The Rb-binding LxCxE motif in the Human ATP-dependent helicase SMARCA2 that mediates binding to the human retinoblastoma protein (RB) to repress S-phase-inducing transcription factor E2F1, thereby preventing cells from entering S phase |
Record No : 83 |
| Instance ID | 10816 | | Regular Expression | RGD | | Motif Instance | RGD | | Bait Uniprot Accession | P10451 | | Bait Uniprot Identifier | OSTP_HUMAN | | Bait Gene Name | SPP1 | | Sequence Position | 159-161 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 20816 | | Interacting Domain | N-terminal Integrin beta subunit | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 8910476 | | Comments | Human Osteopontin N-terminal domain contains the RGD motif that mediates binding to Human Integrin beta-1 (ITGB1) |
Record No : 84 |
| Instance ID | 10821 | | Regular Expression | [LIVMP]x{0,2}(T)Pxx([ST]) | | Motif Instance | LTPPPS | | Bait Uniprot Accession | P36956 | | Bait Uniprot Identifier | SRBP1_HUMAN | | Bait Gene Name | SREBF1 | | Sequence Position | 425-430 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Thr-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Protein kinase assay; ChIP; Mutation analysis; Co-IP | | Interaction ID | 20821 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16825193, 16054087 | | Comments | The TPxxS phospho-dependent degron in Human Sterol regulatory element-binding protein 1 (SREBF1) that serves as a recognition motif for the SCF(FBW7) ubiquitin ligase and enhances its ubiquitination and degradation in a manner dependent on the phosphorylation of T426 and S430 |
Record No : 85 |
| Instance ID | 10851 | | Regular Expression | (Y)xNx | | Motif Instance | YVNV | | Bait Uniprot Accession | P29353 | | Bait Uniprot Identifier | SHC1_HUMAN | | Bait Gene Name | SHC1 | | Sequence Position | 427-430 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Beta turn | | Experimental Method(s) | NMR | | Interaction ID | 20851 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10356320, 9710204 | | Comments | Tyrosine-phosphorylated (Y427) Human SHC-transforming protein 1 (SHC1) binds specifically to the SH2-domain of the human Adapter protein GRB2 |
Record No : 86 |
| Instance ID | 10858 | | Regular Expression | (Y)[QDEVAIL][DENPYHI][IPVGAHS] | | Motif Instance | YQPG | | Bait Uniprot Accession | P12931 | | Bait Uniprot Identifier | SRC_HUMAN | | Bait Gene Name | SRC | | Sequence Position | 530-533 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 20858 | | Interacting Domain | SH2 domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 10360179 | | Comments | The human Proto-oncogene tyrosine-protein kinase SRC is maintained in an assembled, inactive conformation by intramolecular interactions of the phosphorylated C-terminal tail (Tyr-527) with the SH2 domain locks the molecule in an inhibited conformation |
Record No : 87 |
| Instance ID | 10880 | | Regular Expression | PxxPx[KR] | | Motif Instance | PPVPPR | | Bait Uniprot Accession | Q07889 | | Bait Uniprot Identifier | SOS1_HUMAN | | Bait Gene Name | SOS1 | | Sequence Position | 1151-1156 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | ITC; Pull down; Co-IP; Competition binding | | Interaction ID | 20880 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8479541, 23334917 | | Comments | The SH3 domains of Adapter protein GRB2 bind to the carboxy-terminal part of hSos1, the human homologue of the Drosophila guanine-nucleotide-releasing factor for Ras, and the GRB2/SOS1 complex couples activated EGF receptor to Ras signalling |
Record No : 88 |
| Instance ID | 10881 | | Regular Expression | PxxPx[KR] | | Motif Instance | PVPPRR | | Bait Uniprot Accession | Q07889 | | Bait Uniprot Identifier | SOS1_HUMAN | | Bait Gene Name | SOS1 | | Sequence Position | 1152-1157 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Co-IP; Pull down | | Interaction ID | 20881 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8479541 | | Comments | The SH3 domains of Adapter protein GRB2 bind to the carboxy-terminal part of hSos1, the human homologue of the Drosophila guanine-nucleotide-releasing factor for Ras, and the GRB2/SOS1 complex couples activated EGF receptor to Ras signalling |
Record No : 89 |
| Instance ID | 10901 | | Regular Expression | xxx[PV]xxP | | Motif Instance | VPPPVPP | | Bait Uniprot Accession | Q62245 | | Bait Uniprot Identifier | SOS1_MOUSE | | Bait Gene Name | Sos1 | | Sequence Position | 1135-1141 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR | | Interaction ID | 20901 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9135122 | | Comments | Interaction between the N-terminal SH3 domain of Mouse growth factor receptor-bound protein 2 (Grb2) with the mouse Son-of-Sevenless (Sos) protein is mediated by a proline-rich peptide of the mouse Sos1 sequence |
Record No : 90 |
| Instance ID | 10924 | | Regular Expression | xPxAxVxP[^P] | | Motif Instance | RPTAAVTPI | | Bait Uniprot Accession | Q7Z6J0 | | Bait Uniprot Identifier | SH3R1_HUMAN | | Bait Gene Name | SH3RF1 | | Sequence Position | 600-608 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Co-IP | | Interaction ID | 20924 | | Interacting Domain | TRAF-like domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16230351 | | Comments | Human E3 ubiquitin-protein ligase SIAH1 is a binding partner for E3 ubiquitin-protein ligase SH3RF1/ POSH (Plenty of SH3s), a scaffold component of the apoptotic JNK pathway, and thus contributes to promotion of apoptotic death by activating the JNK pathway |
Record No : 91 |
| Instance ID | 10932 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFQVH | | Bait Uniprot Accession | P55014 | | Bait Uniprot Identifier | S12A1_MOUSE | | Bait Gene Name | Slc12a1 | | Sequence Position | 16-20 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Alanine scanning | | Interaction ID | 20932 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12386165 | | Comments | Mouse Kidney-specific Na-K-Cl symporter Slc12a1/Nkcc2 interacts with the conserved C-terminal (CCT) domain of mouse stress-related kinase Stk39/Spak through its RFxV docking motif |
Record No : 92 |
| Instance ID | 10944 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFRVN | | Bait Uniprot Accession | P55012 | | Bait Uniprot Identifier | S12A2_MOUSE | | Bait Gene Name | Slc12a2 | | Sequence Position | 133-137 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20944 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14563843, 17595523 | | Comments | Mouse Basolateral Na-K-Cl symporter Slc12a2/Nkcc1 interacts with the conserved C-terminal (CCT) domain of mouse Oxidative stress-responsive 1 protein (Oxsr1) through its RFxV docking motif (133-137) |
Record No : 93 |
| Instance ID | 10945 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFRVN | | Bait Uniprot Accession | P55012 | | Bait Uniprot Identifier | S12A2_MOUSE | | Bait Gene Name | Slc12a2 | | Sequence Position | 133-137 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20945 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14563843, 17595523 | | Comments | Mouse Basolateral Na-K-Cl symporter Slc12a2/Nkcc1 interacts with the conserved C-terminal (CCT) domain of mouse stress-related kinase Stk39/Spak through its RFxV docking motif (133-137) |
Record No : 94 |
| Instance ID | 10946 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFMVT | | Bait Uniprot Accession | Q924N4 | | Bait Uniprot Identifier | S12A6_MOUSE | | Bait Gene Name | Slc12a6 | | Sequence Position | 14-18 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Y2H; Mutation analysis | | Interaction ID | 20946 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12386165 | | Comments | Mouse Electroneutral K-Cl cotransporter 3 (Kcc3/Slc12a6) interacts with the conserved C-terminal (CCT) domain of mouse stress-related kinase Stk39/Spak through its RFxV docking motif |
Record No : 95 |
| Instance ID | 10947 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFTIS | | Bait Uniprot Accession | P55017 | | Bait Uniprot Identifier | S12A3_HUMAN | | Bait Gene Name | SLC12A3 | | Sequence Position | 19-23 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20947 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18270262 | | Comments | Human Na-Cl cotransporter SLC12A3/NCC interacts with the conserved C-terminal (CCT) domain of human Oxidative stress-responsive 1 protein (OXSR1) through its RFXI motif |
Record No : 96 |
| Instance ID | 10948 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFTIS | | Bait Uniprot Accession | P55017 | | Bait Uniprot Identifier | S12A3_HUMAN | | Bait Gene Name | SLC12A3 | | Sequence Position | 19-23 | | Critical Residues | P1 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20948 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18270262 | | Comments | Human Na-Cl cotransporter SLC12A3/NCC interacts with the conserved C-terminal (CCT) domain of human STE20-related kinase STK39/SPAK through its RFXI motif |
Record No : 97 |
| Instance ID | 10949 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFQVD | | Bait Uniprot Accession | P55012 | | Bait Uniprot Identifier | S12A2_MOUSE | | Bait Gene Name | Slc12a2 | | Sequence Position | 77-81 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20949 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14563843, 17595523 | | Comments | Mouse Basolateral Na-K-Cl symporter Slc12a2/Nkcc1 interacts with the conserved C-terminal (CCT) domain of mouse Oxidative stress-responsive 1 protein (Oxsr1) through its RFxV docking motif (77-81) |
Record No : 98 |
| Instance ID | 10950 | | Regular Expression | RF[^P][IV]x | | Motif Instance | RFQVD | | Bait Uniprot Accession | P55012 | | Bait Uniprot Identifier | S12A2_MOUSE | | Bait Gene Name | Slc12a2 | | Sequence Position | 77-81 | | Critical Residues | P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20950 | | Interacting Domain | Conserved C-Terminal (CCT) domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14563843, 17595523 | | Comments | Mouse Basolateral Na-K-Cl symporter Slc12a2/Nkcc1 interacts with the conserved C-terminal (CCT) domain of mouse stress-related kinase Stk39/Spak through its RFxV docking motif (77-81) |
Record No : 99 |
| Instance ID | 10976 | | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | | Motif Instance | LIDLT | | Bait Uniprot Accession | P39955 | | Bait Uniprot Identifier | SAP1_YEAST | | Bait Gene Name | SAP1 | | Sequence Position | 235-239 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Y2H | | Interaction ID | 20976 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15590687 | | Comments | The potential SUMO-binding motif in Sap1 protein of Saccharomyces cerevisiae that mediates interactions with Ubiquitin-like protein Smt3 in Saccharomyces cerevisiae |
Record No : 100 |
| Instance ID | 10977 | | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | | Motif Instance | IIISDSDDDDDE | | Bait Uniprot Accession | Q7Z333 | | Bait Uniprot Identifier | SETX_HUMAN | | Bait Gene Name | SETX | | Sequence Position | 1014-1025 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Y2H; Mutation analysis | | Interaction ID | 20977 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16524884 | | Comments | The SUMO-interacting motif (SIM) of human Senataxin (SETX), a newly identified helicase mutated in patients suffering from ataxia-ocular apraxia 2, that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1) |
Record No : 101 |
| Instance ID | 10978 | | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | | Motif Instance | IIVISSEDSE | | Bait Uniprot Accession | P23497 | | Bait Uniprot Identifier | SP100_HUMAN | | Bait Gene Name | SP100 | | Sequence Position | 323-332 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Extended conformation | | Experimental Method(s) | Mutation analysis; Y2H; Pull down(GST tag) | | Interaction ID | 20978 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16524884 | | Comments | The SUMO-interacting motif (SIM) of human Nuclear autoantigen SP100 that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1) |
Record No : 102 |
| Instance ID | 10991 | | Regular Expression | ([KR][^ED]{0,5}[ST]xIP[^ED]{5,5})|([^ED]{5,5}[ST]xIP[^ED]{0,5}[KR]) | | Motif Instance | QASRNTRIPHLAGKK | | Bait Uniprot Accession | Q13586 | | Bait Uniprot Identifier | STIM1_HUMAN | | Bait Gene Name | STIM1 | | Sequence Position | 637-651 | | Critical Residues | P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Classical fluorescence spectroscopy; Mutation analysis | | Interaction ID | 20991 | | Interacting Domain | EBH domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19632184 | | Comments | The C-terminal EBH domain of human End-binding protein 1 (EB1) or MAPRE1 binds to the SxIP motif of human Stromal interaction molecule 1 (STIM1) |
Record No : 103 |
| Instance ID | 10994 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | QRSPPDGQ | | Bait Uniprot Accession | P78314 | | Bait Uniprot Identifier | 3BP2_HUMAN | | Bait Gene Name | SH3BP2 | | Sequence Position | 414-421 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence polarization spectroscopy; Alanine scanning; Pull down; Co-IP | | Interaction ID | 20994 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Cherubism | | Inhibitor(s) | Unknown | | Reference(s) | 22153077 | | Comments | The N-terminal region of ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif in human SH3 domain-binding protein 2 (SH3BP2) |
Record No : 104 |
| Instance ID | 11010 | | Regular Expression | xRxx[PGAV][DEIP]Gx | | Motif Instance | SRSAGDGT | | Bait Uniprot Accession | O43815 | | Bait Uniprot Identifier | STRN_HUMAN | | Bait Gene Name | STRN | | Sequence Position | 301-308 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence polarization spectroscopy; Mutation analysis; Co-IP | | Interaction ID | 21010 | | Interacting Domain | Ankyrin repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22153077 | | Comments | The N-terminal region of ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif in human Striatin (STRN) |
Record No : 105 |
| Instance ID | 11022 | | Regular Expression | [PSAT]x[QE]E | | Motif Instance | PVQE | | Bait Uniprot Accession | P18347 | | Bait Uniprot Identifier | TSTP_SHV21 | | Bait Gene Name | STP | | Sequence Position | 60-63 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Western blot; Co-IP; Mutation analysis | | Interaction ID | 21022 | | Interacting Domain | MATH domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 10196286 | | Comments | The Transforming STP oncoprotein of the herpesvirus saimiri (HVS) are found to be stably associated with human TNF receptor-associated factor 2 (TRAF2) through its TRAF2-binding consensus motif |
Record No : 106 |
| Instance ID | 11036 | | Regular Expression | [KR]{1,4}[KR]x[KR]Wx | | Motif Instance | KRKSRWD | | Bait Uniprot Accession | O75533 | | Bait Uniprot Identifier | SF3B1_HUMAN | | Bait Gene Name | SF3B1 | | Sequence Position | 333-339 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; NMR; Pull down; Mutation analysis; ITC | | Interaction ID | 21036 | | Interacting Domain | UHM domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17589525, 16376933 | | Comments | Human Splicing factor 45 (SPF45)/ RNA-binding motif protein 17 (RBM17) binds to the UHM-ligand motif (ULM) present in human Splicing factor 3B subunit 1 (SF3B1) for regulating the alternative splicing of apoptosis regulatory gene FAS |
Record No : 107 |
| Instance ID | 11037 | | Regular Expression | [KR]{1,4}[KR]x[KR]Wx | | Motif Instance | KKRKRSRWN | | Bait Uniprot Accession | Q15637 | | Bait Uniprot Identifier | SF01_HUMAN | | Bait Gene Name | SF1 | | Sequence Position | 15-23 | | Critical Residues | P7; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; NMR | | Interaction ID | 21037 | | Interacting Domain | UHM domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12718882 | | Comments | The C-terminal RRM (RRM3) of human Splicing factor U2AF65/U2AF2 binds to the N-terminal UHM ligand motif (ULM) of human Splicing factor 1 (SF1) |
Record No : 108 |
| Instance ID | 11051 | | Regular Expression | PPxY | | Motif Instance | PPRY | | Bait Uniprot Accession | P08363 | | Bait Uniprot Identifier | VP8_BTV10 | | Bait Gene Name | S10 | | Sequence Position | 36-39 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Western blot; Mutation analysis | | Interaction ID | 21051 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16352570 | | Comments | Non-structural protein NS3 (S10) of Bluetongue virus (BTV) harbors a PPXY late-domain motif that allows NS3 to bind Human E3 ubiquitin-protein ligase NEDD4 |
Record No : 109 |
| Instance ID | 11058 | | Regular Expression | PPxY | | Motif Instance | PPAY | | Bait Uniprot Accession | Q15797 | | Bait Uniprot Identifier | SMAD1_HUMAN | | Bait Gene Name | SMAD1 | | Sequence Position | 224-227 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | NMR | | Interaction ID | 21058 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21685363 | | Comments | The PY motif of human SMAD1 that binds to the WW domain of human E3 ubiquitin-protein ligase SMURF1 |
Record No : 110 |
| Instance ID | 11060 | | Regular Expression | PPxY | | Motif Instance | PPKY | | Bait Uniprot Accession | P51170 | | Bait Uniprot Identifier | SCNNG_HUMAN | | Bait Gene Name | SCNN1G | | Sequence Position | 624-627 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; RNA interference; Ubiquitinase assay; Mutation analysis; Western blot | | Interaction ID | 21060 | | Interacting Domain | WW domain | | Disease Association(s) | Liddle's Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 17502380 | | Comments | The PPXY motif of human Epithelial Na(+) channel subunit gamma (SCNN1G) that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4L/Nedd4-2 |
Record No : 111 |
| Instance ID | 11061 | | Regular Expression | PPxY | | Motif Instance | PPNY | | Bait Uniprot Accession | P51168 | | Bait Uniprot Identifier | SCNNB_HUMAN | | Bait Gene Name | SCNN1B | | Sequence Position | 617-620 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; RNA interference; Ubiquitinase assay; Mutation analysis; Western blot | | Interaction ID | 21061 | | Interacting Domain | WW domain | | Disease Association(s) | Liddle's Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 17502380 | | Comments | The PPXY motif of human Epithelial Na(+) channel subunit beta (SCNN1B) that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4L/Nedd4-2 |
Record No : 112 |
| Instance ID | 11062 | | Regular Expression | PPxY | | Motif Instance | PPAY | | Bait Uniprot Accession | P37088 | | Bait Uniprot Identifier | SCNNA_HUMAN | | Bait Gene Name | SCNN1A | | Sequence Position | 641-644 | | Critical Residues | P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; RNA interference; Ubiquitinase assay; Mutation analysis; Western blot | | Interaction ID | 21062 | | Interacting Domain | WW domain | | Disease Association(s) | Liddle's Syndrome | | Inhibitor(s) | Unknown | | Reference(s) | 17502380 | | Comments | The PPXY motif of human Epithelial Na(+) channel subunit alpha (SCNN1A) that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4L/Nedd4-2 |
Record No : 113 |
| Instance ID | 11071 | | Regular Expression | xxx([ST])Px | | Motif Instance | CVLSPV | | Bait Uniprot Accession | Q9Y6H5 | | Bait Uniprot Identifier | SNCAP_HUMAN | | Bait Gene Name | SNCAIP | | Sequence Position | 208-213 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis; Classical fluorescence spectroscopy; Phosphatase assay; Pull down | | Interaction ID | 21071 | | Interacting Domain | WW domain | | Disease Association(s) | Parkinson disease | | Inhibitor(s) | Unknown | | Reference(s) | 16365047 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-211-Pro motif of human Synphilin-1 (SNCAIP), an alpha-synuclein partner, and enhances its interaction with alpha-synuclein, thus likely facilitating the formation of alpha-synuclein inclusions |
Record No : 114 |
| Instance ID | 11074 | | Regular Expression | xxx([ST])Px | | Motif Instance | SDSSPS | | Bait Uniprot Accession | P35210 | | Bait Uniprot Identifier | SPT23_YEAST | | Bait Gene Name | SPT23 | | Sequence Position | 651-656 | | Critical Residues | P4; P5 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Phosphatase assay; Pull down; Alanine scanning | | Interaction ID | 21074 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19597489 | | Comments | The yeast peptidyl-prolyl cis/trans isomerase Pin1 (Ess1) is essential for viability because it controls the NF-kappaB-related Spt23 transcription factor involved in unsaturated fatty-acid synthesis via an interaction with phosphorylated Ser-654 of Spt23 |
Record No : 115 |
| Instance ID | 11076 | | Regular Expression | xxx([ST])Px | | Motif Instance | PVKSPH | | Bait Uniprot Accession | Q9Y6H5 | | Bait Uniprot Identifier | SNCAP_HUMAN | | Bait Gene Name | SNCAIP | | Sequence Position | 212-217 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis; Classical fluorescence spectroscopy; Phosphatase assay; Pull down | | Interaction ID | 21076 | | Interacting Domain | WW domain | | Disease Association(s) | Parkinson disease | | Inhibitor(s) | Unknown | | Reference(s) | 16365047 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-215-Pro motif of human Synphilin-1 (SNCAIP), an alpha-synuclein partner, and enhances its interaction with alpha-synuclein, thus likely facilitating the formation of alpha-synuclein inclusions |
Record No : 116 |
| Instance ID | 11087 | | Regular Expression | xxx([ST])Px | | Motif Instance | DAGSPN | | Bait Uniprot Accession | P84022 | | Bait Uniprot Identifier | SMAD3_HUMAN | | Bait Gene Name | SMAD3 | | Sequence Position | 201-206 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Alanine scanning | | Interaction ID | 21087 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19122240 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-204-Pro motif of human SMAD3 thereby inducing its degradation |
Record No : 117 |
| Instance ID | 11088 | | Regular Expression | xxx([ST])Px | | Motif Instance | TPSTPG | | Bait Uniprot Accession | Q9BR01 | | Bait Uniprot Identifier | ST4A1_HUMAN | | Bait Gene Name | SULT4A1 | | Sequence Position | 8-13 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Y2H; Co-IP; Mutation analysis | | Interaction ID | 21088 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19439498, 20920535 | | Comments | The human cytosolic Aryl Sulfotransferase 4A1 interacts with the human Peptidyl-prolyl cis-trans isomerase PIN1 through its Thr-11-Pro motif |
Record No : 118 |
| Instance ID | 11105 | | Regular Expression | xxx([ST])Px | | Motif Instance | IIFSPK | | Bait Uniprot Accession | O64645 | | Bait Uniprot Identifier | SOC1_ARATH | | Bait Gene Name | SOC1 | | Sequence Position | 46-51 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence technology; Alanine scanning; Phosphatase assay; NMR; Pull down(GST tag); BiFC assay | | Interaction ID | 21105 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20129060 | | Comments | Arabidopsis Peptidyl-prolyl cis-trans isomerase Pin1/PIN1At interacts with the phosphorylated Ser-49-Pro motif of Arabidopsis MADS-box protein SOC1 and thereby regulates flowering time in Arabidopsis |
Record No : 119 |
| Instance ID | 11107 | | Regular Expression | xxx([ST])Px | | Motif Instance | EESSPS | | Bait Uniprot Accession | O64645 | | Bait Uniprot Identifier | SOC1_ARATH | | Bait Gene Name | SOC1 | | Sequence Position | 192-197 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Fluorescence technology; Alanine scanning; Phosphatase assay | | Interaction ID | 21107 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20129060 | | Comments | Arabidopsis Peptidyl-prolyl cis-trans isomerase Pin1/PIN1At interacts with the phosphorylated Ser-195-Pro motif of Arabidopsis MADS-box protein SOC1 and thereby regulates flowering time in Arabidopsis |
Record No : 120 |
| Instance ID | 11114 | | Regular Expression | xxx([ST])Px | | Motif Instance | IPETPP | | Bait Uniprot Accession | P84022 | | Bait Uniprot Identifier | SMAD3_HUMAN | | Bait Gene Name | SMAD3 | | Sequence Position | 176-181 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Co-IP; Pull down; Alanine scanning | | Interaction ID | 21114 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 21685363, 19122240 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Thr-179-Pro motif of human SMAD3 thereby inducing its degradation |
Record No : 121 |
| Instance ID | 11115 | | Regular Expression | xxx([ST])Px | | Motif Instance | NPMSPA | | Bait Uniprot Accession | P84022 | | Bait Uniprot Identifier | SMAD3_HUMAN | | Bait Gene Name | SMAD3 | | Sequence Position | 210-215 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Alanine scanning | | Interaction ID | 21115 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19122240 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-213-Pro motif of human SMAD3 thereby inducing its degradation |
Record No : 122 |
| Instance ID | 11116 | | Regular Expression | xxx([ST])Px | | Motif Instance | PNLSPN | | Bait Uniprot Accession | P84022 | | Bait Uniprot Identifier | SMAD3_HUMAN | | Bait Gene Name | SMAD3 | | Sequence Position | 205-210 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Alanine scanning | | Interaction ID | 21116 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 19122240 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-208-Pro motif of human SMAD3 thereby inducing its degradation |
Record No : 123 |
| Instance ID | 11127 | | Regular Expression | xxx([ST])Px | | Motif Instance | EAETPS | | Bait Uniprot Accession | Q9BR01 | | Bait Uniprot Identifier | ST4A1_HUMAN | | Bait Gene Name | SULT4A1 | | Sequence Position | 5-10 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Y2H; Co-IP; Mutation analysis | | Interaction ID | 21127 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19439498, 20920535 | | Comments | The human cytosolic Aryl Sulfotransferase 4A1 interacts with the human Peptidyl-prolyl cis-trans isomerase PIN1 through its Thr-8-Pro motif |
Record No : 124 |
| Instance ID | 11136 | | Regular Expression | xxx([ST])Px | | Motif Instance | LPMSPR | | Bait Uniprot Accession | P40763 | | Bait Uniprot Identifier | STAT3_HUMAN | | Bait Gene Name | STAT3 | | Sequence Position | 724-729 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Ser-P4 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Co-IP; Alanine scanning | | Interaction ID | 21136 | | Interacting Domain | WW domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17563747 | | Comments | The human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Ser-727-Pro motif of human Acute-phase response factor STAT3 upon cytokine/growth factor stimulation and promotes STAT3 transcriptional activity |
Record No : 125 |
| Instance ID | 11198 | | Regular Expression | PPLP | | Motif Instance | PPLP | | Bait Uniprot Accession | Q64213 | | Bait Uniprot Identifier | SF01_MOUSE | | Bait Gene Name | Sf1 | | Sequence Position | 575-578 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Alanine scanning; Far Western blotting; SPR | | Interaction ID | 21198 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9171351 | | Comments | The PPLP motif in mouse Splicing factor 1 (Sf1) that is recognized by the group II WW domain of mouse Formin-binding protein 11 (Fbp11) |
Record No : 126 |
| Instance ID | 11267 | | Regular Expression | [KR]xTQTx | | Motif Instance | KATQTD | | Bait Uniprot Accession | P40688 | | Bait Uniprot Identifier | SWA_DROME | | Bait Gene Name | swa | | Sequence Position | 291-296 | | Critical Residues | P1; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; NMR; Y2H; pull down(GST tag); protection from proteolytic digestion | | Interaction ID | 21267 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15078108, 10783235, 17570393 | | Comments | An interaction between Drosophila LC8 (or ctp), the highly conserved light-chain subunit of cytoplasmic dynein, and the Drosophila protein swallow (swa) promotes assembly of the coiled-coil domain of swallow protein |
Record No : 127 |
| Instance ID | 11268 | | Regular Expression | [KR]xTQTx | | Motif Instance | KQTQTT | | Bait Uniprot Accession | Q24246 | | Bait Uniprot Identifier | DYIN_DROME | | Bait Gene Name | sw | | Sequence Position | 130-135 | | Critical Residues | P1; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography; NMR; pull down(GST tag); protection from proteolytic digestion; Far-UV CD spectropolarimetry; EMSA; Fluorescence Spectroscopy | | Interaction ID | 21268 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17570393, 15581372 | | Comments | The N-terminal domain of Drosophila Cytoplasmic dynein 1 intermediate chain (sw), is highly disordered, but upon binding to Drosophila cytoplasmic dynein light-chain subunit LC8 (or ctp), it undergoes a significant conformational change to a more ordered structure |
Record No : 128 |
| Instance ID | 11338 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | ERAIQTD | | Bait Uniprot Accession | B5DF41 | | Bait Uniprot Identifier | SNPH_RAT | | Bait Gene Name | Snph | | Sequence Position | 311-317 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21338 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in rat Syntaphilin (Snph) that interacts with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8) |
Record No : 129 |
| Instance ID | 11339 | | Regular Expression | [DS]Kx[TVI]Q[TV][DE] | | Motif Instance | ERAIQTD | | Bait Uniprot Accession | B5DF41 | | Bait Uniprot Identifier | SNPH_RAT | | Bait Gene Name | Snph | | Sequence Position | 311-317 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21339 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21533121 | | Comments | The LC8 dynein light chain binding motif in rat Syntaphilin (Snph) that interacts with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2) |
Record No : 130 |
| Instance ID | 11642 | | Regular Expression | PPxY | | Motif Instance | PPTY | | Bait Uniprot Accession | Q8N3V7 | | Bait Uniprot Identifier | SYNPO_HUMAN | | Bait Gene Name | SYNPO | | Sequence Position | 562-565 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21642 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12042308 | | Comments | PPxY motif (562-565) in synaptopodin that mediates its interaction with the second WW domain of MAGI-1 |
Record No : 131 |
| Instance ID | 11643 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | Q8N3V7 | | Bait Uniprot Identifier | SYNPO_HUMAN | | Bait Gene Name | SYNPO | | Sequence Position | 581-584 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21643 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12042308 | | Comments | PPxY motif (581-584) in synaptopodin that mediates its interaction with the second WW domain of MAGI-1 |
Record No : 132 |
| Instance ID | 11644 | | Regular Expression | PPxY | | Motif Instance | PPTY | | Bait Uniprot Accession | Q8N3V7 | | Bait Uniprot Identifier | SYNPO_HUMAN | | Bait Gene Name | SYNPO | | Sequence Position | 562-565 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21644 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18596123 | | Comments | PPxY motif (562-565) in synaptopodin that mediates its interaction with both WW domains of KIBRA (WWC1) |
Record No : 133 |
| Instance ID | 11645 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | Q8N3V7 | | Bait Uniprot Identifier | SYNPO_HUMAN | | Bait Gene Name | SYNPO | | Sequence Position | 581-584 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21645 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18596123 | | Comments | PPxY motif (581-584) in synaptopodin that mediates its interaction with both WW domains of KIBRA (WWC1) |
Record No : 134 |
| Instance ID | 11658 | | Regular Expression | [YFG][YFHW][WFA]$ | | Motif Instance | FYA | | Bait Uniprot Accession | P18827 | | Bait Uniprot Identifier | SDC1_HUMAN | | Bait Gene Name | SDC1 | | Sequence Position | 308-310 | | Critical Residues | P2; P3 | | Motif PTM(s) | Phosphorylation at Tyr-P2 | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; NMR; Fluorescence anisotropy binding assay | | Interaction ID | 21658 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20361982 | | Comments | Class II-type PDZ-binding motif in the C-terminal sequence of human Syndecan-1 that binds to the Tiam1 PDZ domain |
Record No : 135 |
| Instance ID | 11659 | | Regular Expression | [YFG][YFHW][WFA]$ | | Motif Instance | FYA | | Bait Uniprot Accession | P18827 | | Bait Uniprot Identifier | SDC1_HUMAN | | Bait Gene Name | SDC1 | | Sequence Position | 308-310 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21659 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9660868 | | Comments | COOH-terminal sequence of human syndecan-1 that binds to the PDZ domain of hCASK |
Record No : 136 |
| Instance ID | 11660 | | Regular Expression | [YFG][YFHW][WFA]$ | | Motif Instance | FYA | | Bait Uniprot Accession | P34741 | | Bait Uniprot Identifier | SDC2_HUMAN | | Bait Gene Name | SDC2 | | Sequence Position | 199-201 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 21660 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9660868 | | Comments | COOH-terminal sequence of human syndecan-2 that binds to the PDZ domain of hCASK |
Record No : 137 |
| Instance ID | 11661 | | Regular Expression | [YFG][YFHW][WFA]$ | | Motif Instance | FYA | | Bait Uniprot Accession | O75056 | | Bait Uniprot Identifier | SDC3_HUMAN | | Bait Gene Name | SDC3 | | Sequence Position | 440-442 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21661 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9660868 | | Comments | COOH-terminal sequence of human syndecan-3 that may bind to the PDZ domain of hCASK |
Record No : 138 |
| Instance ID | 11662 | | Regular Expression | [YFG][YFHW][WFA]$ | | Motif Instance | FYA | | Bait Uniprot Accession | P31431 | | Bait Uniprot Identifier | SDC4_HUMAN | | Bait Gene Name | SDC4 | | Sequence Position | 196-198 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21662 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9660868 | | Comments | COOH-terminal sequence of human syndecan-4 that may bind to the PDZ domain of hCASK |
Record No : 139 |
| Instance ID | 11663 | | Regular Expression | [YFG][YFHW][WFA]$ | | Motif Instance | FYA | | Bait Uniprot Accession | P34741 | | Bait Uniprot Identifier | SDC2_HUMAN | | Bait Gene Name | SDC2 | | Sequence Position | 199-201 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | SPR; Mutational analysis; Y2H; Ligand blotting assay | | Interaction ID | 21663 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9391086 | | Comments | COOH-terminal sequence of human syndecan-2 that binds to both PDZ domains of human Syntenin-1 |
Record No : 140 |
| Instance ID | 11664 | | Regular Expression | [YFG][YFHW][WFA]$ | | Motif Instance | FYA | | Bait Uniprot Accession | P43407 | | Bait Uniprot Identifier | SDC2_MOUSE | | Bait Gene Name | Sdc2 | | Sequence Position | 200-202 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Y2H | | Interaction ID | 21664 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11018053 | | Comments | The C-terminal conserved sequence of mouse syndecan-2 cytoplasmic domain that binds to the mouse Synbindin (Trappc4) and causes the clustering of synbindin in dendritic spines |
Record No : 141 |
| Instance ID | 11665 | | Regular Expression | [YFG][YFHW][WFA]$ | | Motif Instance | FYA | | Bait Uniprot Accession | P34901 | | Bait Uniprot Identifier | SDC4_RAT | | Bait Gene Name | Sdc4 | | Sequence Position | 200-202 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Y2H | | Interaction ID | 21665 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10911369 | | Comments | Class II-type PDZ-binding motif in the C-terminal sequence of rat cytoplasmic domain of syndecan-4 that binds to the mouse synectin (Gipc1) PDZ domain |
Record No : 142 |
| Instance ID | 11691 | | Regular Expression | Wx{2,3}[FW] | | Motif Instance | WVSF | | Bait Uniprot Accession | Q8WXE9 | | Bait Uniprot Identifier | STON2_HUMAN | | Bait Gene Name | STON2 | | Sequence Position | 15-18 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21691 | | Interacting Domain | Alpha-ear domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14565955, 14726597 | | Comments | AP-2 interaction motif I(15-18) in human Stonin-2 that mediates binding to the alpha-ear domain of AP-2 complex subunit alpha-1 or Alpha1-adaptin |
Record No : 143 |
| Instance ID | 11692 | | Regular Expression | Wx{2,3}[FW] | | Motif Instance | WVQF | | Bait Uniprot Accession | Q8WXE9 | | Bait Uniprot Identifier | STON2_HUMAN | | Bait Gene Name | STON2 | | Sequence Position | 102-105 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21692 | | Interacting Domain | Alpha-ear domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14565955, 14726597 | | Comments | AP-2 interaction motif II(102-105) in human Stonin-2 that mediates binding to the alpha-ear domain of AP-2 complex subunit alpha-1 or Alpha1-adaptin |
Record No : 144 |
| Instance ID | 11693 | | Regular Expression | Wx{2,3}[FW] | | Motif Instance | WVTF | | Bait Uniprot Accession | Q8WXE9 | | Bait Uniprot Identifier | STON2_HUMAN | | Bait Gene Name | STON2 | | Sequence Position | 232-235 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21693 | | Interacting Domain | Alpha-ear domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14565955, 14726597 | | Comments | AP-2 interaction motif III(232-235) in human Stonin-2 that mediates binding to the alpha-ear domain of AP-2 complex subunit alpha-1 or Alpha1-adaptin |
Record No : 145 |
| Instance ID | 11694 | | Regular Expression | Wx{2,3}[FW] | | Motif Instance | WVTF | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Sequence Position | 1481-1484 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Pull down(GST tag) | | Interaction ID | 21694 | | Interacting Domain | Alpha-ear domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 14565955 | | Comments | AP-2 interaction motif in the non-neuronal 170-kDa long splice isoform of synaptojanin 1, termed SJ170, that mediates binding to the alpha-ear domain of AP-2 complex subunit alpha-1 or Alpha1-adaptin and is likely to promote efficient targeting of the polyphosphatase to the assembling clathrin lattice in non-neuronal cells |
Record No : 146 |
| Instance ID | 11701 | | Regular Expression | P[KR]RPPxPR | | Motif Instance | PKRPPPPR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Sequence Position | 1105-1112 | | Critical Residues | P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21701 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding P[KR]RPPxPR motif (1105-1112) in human Synaptojanin-1 that binds the SH3 domain of human Endophilin-1 (SH3GL2) |
Record No : 147 |
| Instance ID | 11702 | | Regular Expression | P[KR]RPPxPR | | Motif Instance | PKRPPPPR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Sequence Position | 1105-1112 | | Critical Residues | P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21702 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding P[KR]RPPxPR motif (1105-1112) in human Synaptojanin-1 that binds the SH3 domain of human Endophilin-2 (SH3GL1) |
Record No : 148 |
| Instance ID | 11703 | | Regular Expression | P[KR]RPPxPR | | Motif Instance | PKRPPPPR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Sequence Position | 1105-1112 | | Critical Residues | P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21703 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding P[KR]RPPxPR motif (1105-1112) in human Synaptojanin-1 that binds the SH3 domain of human Endophilin-3 (SH3GL3) |
Record No : 149 |
| Instance ID | 11704 | | Regular Expression | PxxPxR | | Motif Instance | PIRPSR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Sequence Position | 1065-1070 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21704 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding PxxPxR motif I (1065-1070) in human Synaptojanin-1 that binds the SH3 domain of human Endophilin-1 (SH3GL2) |
Record No : 150 |
| Instance ID | 11705 | | Regular Expression | PxxPxR | | Motif Instance | PIRPSR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Sequence Position | 1065-1070 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21705 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding PxxPxR motif I (1065-1070) in human Synaptojanin-1 that binds the SH3 domain of human Endophilin-2 (SH3GL1) |
Record No : 151 |
| Instance ID | 11706 | | Regular Expression | PxxPxR | | Motif Instance | PIRPSR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Sequence Position | 1065-1070 | | Critical Residues | P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21706 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding PxxPxR motif I (1065-1070) in human Synaptojanin-1 that binds the SH3 domain of human Endophilin-3 (SH3GL3) |
Record No : 152 |
| Instance ID | 11707 | | Regular Expression | PxxPxR | | Motif Instance | PIRPSR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Sequence Position | 1065-1070 | | Critical Residues | P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21707 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding PxxPxR motif I (1065-1070) in human Synaptojanin-1 that binds the SH3 domain of human Amphiphysin |
Record No : 153 |
| Instance ID | 11708 | | Regular Expression | PxxPxR | | Motif Instance | PAPPQR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Sequence Position | 1120-1125 | | Critical Residues | P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21708 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding PxxPxR motif II (1120-1125) in human Synaptojanin-1 that binds the SH3 domain of human Amphiphysin |
Record No : 154 |
| Instance ID | 11709 | | Regular Expression | PxxPxR | | Motif Instance | PTIPPR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Sequence Position | 1196-1201 | | Critical Residues | P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21709 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding PxxPxR motif III (1196-1201) in human Synaptojanin-1 that binds the SH3 domain of human Amphiphysin |
Record No : 155 |
| Instance ID | 11710 | | Regular Expression | PxxPxR | | Motif Instance | PQPPPR | | Bait Uniprot Accession | O43426 | | Bait Uniprot Identifier | SYNJ1_HUMAN | | Bait Gene Name | SYNJ1 | | Sequence Position | 1284-1289 | | Critical Residues | P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay | | Interaction ID | 21710 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10542231, 9341169 | | Comments | The SH3 domain-binding PxxPxR motif IV (1284-1289) in human Synaptojanin-1 that binds the SH3 domain of human Amphiphysin |
Record No : 156 |
| Instance ID | 11723 | | Regular Expression | PxxPxR | | Motif Instance | PPVPPR | | Bait Uniprot Accession | Q07889 | | Bait Uniprot Identifier | SOS1_HUMAN | | Bait Gene Name | SOS1 | | Sequence Position | 1151-1156 | | Critical Residues | P1; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Peptide binding assay; SPR; ITC | | Interaction ID | 21723 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18778683, 8493579, 9383403, 7629138 | | Comments | The SH3 domain-binding PxxPxR motif 2 (1151-1156) in human hSos1 protein that binds to the SH3 domains of human adapter protein GRB2 for the transduction of signals from receptor tyrosine kinases to Ras |
Record No : 157 |
| Instance ID | 11724 | | Regular Expression | PxxPxR | | Motif Instance | PAIPPR | | Bait Uniprot Accession | Q07889 | | Bait Uniprot Identifier | SOS1_HUMAN | | Bait Gene Name | SOS1 | | Sequence Position | 1180-1185 | | Critical Residues | P1; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21724 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8493579, 9383403, 7629138 | | Comments | The SH3 domain-binding PxxPxR motif 3 (1180-1185) in human hSos1 protein that binds to the SH3 domains of human adapter protein GRB2 for the transduction of signals from receptor tyrosine kinases to Ras |
Record No : 158 |
| Instance ID | 11725 | | Regular Expression | PxxPxR | | Motif Instance | PLLPPR | | Bait Uniprot Accession | Q07889 | | Bait Uniprot Identifier | SOS1_HUMAN | | Bait Gene Name | SOS1 | | Sequence Position | 1212-1217 | | Critical Residues | P1; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21725 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8493579, 9383403, 7629138 | | Comments | The SH3 domain-binding PxxPxR motif 4 (1212-1217) in human hSos1 protein that binds to the SH3 domains of human adapter protein GRB2 for the transduction of signals from receptor tyrosine kinases to Ras |
Record No : 159 |
| Instance ID | 11726 | | Regular Expression | PxxPxR | | Motif Instance | PPVPPR | | Bait Uniprot Accession | Q07889 | | Bait Uniprot Identifier | SOS1_HUMAN | | Bait Gene Name | SOS1 | | Sequence Position | 1290-1295 | | Critical Residues | P1; P4; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21726 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8493579, 9383403, 7629138 | | Comments | The SH3 domain-binding PxxPxR motif 6 (1290-1295) in human hSos1 protein that binds to the SH3 domains of human adapter protein GRB2 for the transduction of signals from receptor tyrosine kinases to Ras |
Record No : 160 |
| Instance ID | 11727 | | Regular Expression | PxxPxR | | Motif Instance | PPLPPR | | Bait Uniprot Accession | Q07890 | | Bait Uniprot Identifier | SOS2_HUMAN | | Bait Gene Name | SOS2 | | Sequence Position | 1147-1152 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21727 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7629138 | | Comments | The SH3 domain-binding PxxPxR motif I (1147-1152) in human hSos2 protein that binds to the SH3 domains of human adapter protein GRB2 |
Record No : 161 |
| Instance ID | 11728 | | Regular Expression | PxxPxR | | Motif Instance | PAIPPR | | Bait Uniprot Accession | Q07890 | | Bait Uniprot Identifier | SOS2_HUMAN | | Bait Gene Name | SOS2 | | Sequence Position | 1173-1178 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21728 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7629138 | | Comments | The SH3 domain-binding PxxPxR motif II (1173-1178) in human hSos2 protein that binds to the SH3 domains of human adapter protein GRB2 |
Record No : 162 |
| Instance ID | 11729 | | Regular Expression | PxxPxR | | Motif Instance | PPPPPR | | Bait Uniprot Accession | Q07890 | | Bait Uniprot Identifier | SOS2_HUMAN | | Bait Gene Name | SOS2 | | Sequence Position | 1204-1209 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21729 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7629138 | | Comments | The SH3 domain-binding PxxPxR motif III (1204-1209) in human hSos2 protein that binds to the SH3 domains of human adapter protein GRB2 |
Record No : 163 |
| Instance ID | 11730 | | Regular Expression | PxxPxR | | Motif Instance | PPVPLR | | Bait Uniprot Accession | Q07890 | | Bait Uniprot Identifier | SOS2_HUMAN | | Bait Gene Name | SOS2 | | Sequence Position | 1217-1222 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21730 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7629138 | | Comments | The SH3 domain-binding PxxPxR motif IV (1217-1222) in human hSos2 protein that binds to the SH3 domains of human adapter protein GRB2 |
Record No : 164 |
| Instance ID | 11731 | | Regular Expression | PxxPxR | | Motif Instance | PPVPPR | | Bait Uniprot Accession | Q07890 | | Bait Uniprot Identifier | SOS2_HUMAN | | Bait Gene Name | SOS2 | | Sequence Position | 1290-1295 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21731 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7629138 | | Comments | The SH3 domain-binding PxxPxR motif V (1290-1295) in human hSos2 protein that binds to the SH3 domains of human adapter protein GRB2 |
Record No : 165 |
| Instance ID | 11739 | | Regular Expression | xPxxP | | Motif Instance | PPQKP | | Bait Uniprot Accession | P09951 | | Bait Uniprot Identifier | SYN1_RAT | | Bait Gene Name | Syn1 | | Sequence Position | 588-592 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); Competition binding assay | | Interaction ID | 21739 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8022809, 10899172 | | Comments | The SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domains of human adapter protein GRB2 |
Record No : 166 |
| Instance ID | 11740 | | Regular Expression | xPxxP | | Motif Instance | GPPHP | | Bait Uniprot Accession | P09951 | | Bait Uniprot Identifier | SYN1_RAT | | Bait Gene Name | Syn1 | | Sequence Position | 653-657 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); Competition binding assay | | Interaction ID | 21740 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domain of human Amphiphysin I |
Record No : 167 |
| Instance ID | 11741 | | Regular Expression | xPxxP | | Motif Instance | GPAGP | | Bait Uniprot Accession | P09951 | | Bait Uniprot Identifier | SYN1_RAT | | Bait Gene Name | Syn1 | | Sequence Position | 594-598 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); Competition binding assay | | Interaction ID | 21741 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domain of human Amphiphysin II |
Record No : 168 |
| Instance ID | 11742 | | Regular Expression | xPxxP | | Motif Instance | RPSGP | | Bait Uniprot Accession | P09951 | | Bait Uniprot Identifier | SYN1_RAT | | Bait Gene Name | Syn1 | | Sequence Position | 620-624 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); Competition binding assay | | Interaction ID | 21742 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domain of human Amphiphysin II |
Record No : 169 |
| Instance ID | 11743 | | Regular Expression | xPxxP | | Motif Instance | RPTKP | | Bait Uniprot Accession | P09951 | | Bait Uniprot Identifier | SYN1_RAT | | Bait Gene Name | Syn1 | | Sequence Position | 629-633 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); Competition binding assay | | Interaction ID | 21743 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domain of human Amphiphysin II |
Record No : 170 |
| Instance ID | 11744 | | Regular Expression | xPxxP | | Motif Instance | PPQKP | | Bait Uniprot Accession | P09951 | | Bait Uniprot Identifier | SYN1_RAT | | Bait Gene Name | Syn1 | | Sequence Position | 588-592 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); Competition binding assay | | Interaction ID | 21744 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domain of chicken c-Src |
Record No : 171 |
| Instance ID | 11745 | | Regular Expression | xPxxP | | Motif Instance | GPGAP | | Bait Uniprot Accession | P09951 | | Bait Uniprot Identifier | SYN1_RAT | | Bait Gene Name | Syn1 | | Sequence Position | 537-541 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag); Competition binding assay | | Interaction ID | 21745 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domain of human Phospholipase C-gamma-1 |
Record No : 172 |
| Instance ID | 11746 | | Regular Expression | xPxxP | | Motif Instance | PPQKP | | Bait Uniprot Accession | P17599 | | Bait Uniprot Identifier | SYN1_BOVIN | | Bait Gene Name | SYN1 | | Sequence Position | 590-594 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21746 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domains of human adapter protein GRB2 |
Record No : 173 |
| Instance ID | 11747 | | Regular Expression | xPxxP | | Motif Instance | GPPHP | | Bait Uniprot Accession | P17599 | | Bait Uniprot Identifier | SYN1_BOVIN | | Bait Gene Name | SYN1 | | Sequence Position | 655-659 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21747 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domain of human Amphiphysin I |
Record No : 174 |
| Instance ID | 11748 | | Regular Expression | xPxxP | | Motif Instance | GPAGP | | Bait Uniprot Accession | P17599 | | Bait Uniprot Identifier | SYN1_BOVIN | | Bait Gene Name | SYN1 | | Sequence Position | 596-600 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21748 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domain of human Amphiphysin II |
Record No : 175 |
| Instance ID | 11749 | | Regular Expression | xPxxP | | Motif Instance | RPSGP | | Bait Uniprot Accession | P17599 | | Bait Uniprot Identifier | SYN1_BOVIN | | Bait Gene Name | SYN1 | | Sequence Position | 622-626 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21749 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domain of human Amphiphysin II |
Record No : 176 |
| Instance ID | 11750 | | Regular Expression | xPxxP | | Motif Instance | RPTKP | | Bait Uniprot Accession | P17599 | | Bait Uniprot Identifier | SYN1_BOVIN | | Bait Gene Name | SYN1 | | Sequence Position | 631-635 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21750 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domain of human Amphiphysin II |
Record No : 177 |
| Instance ID | 11751 | | Regular Expression | xPxxP | | Motif Instance | PPQKP | | Bait Uniprot Accession | P17599 | | Bait Uniprot Identifier | SYN1_BOVIN | | Bait Gene Name | SYN1 | | Sequence Position | 590-594 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21751 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domain of chicken c-Src |
Record No : 178 |
| Instance ID | 11752 | | Regular Expression | xPxxP | | Motif Instance | GPGAP | | Bait Uniprot Accession | P17599 | | Bait Uniprot Identifier | SYN1_BOVIN | | Bait Gene Name | SYN1 | | Sequence Position | 539-543 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21752 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10899172 | | Comments | The SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domain of human Phospholipase C-gamma-1 |
Record No : 179 |
| Instance ID | 11767 | | Regular Expression | PPxPxKxK | | Motif Instance | PPVPPKPK | | Bait Uniprot Accession | Q9UPX8 | | Bait Uniprot Identifier | SHAN2_HUMAN | | Bait Gene Name | SHANK2 | | Sequence Position | 1165-1172 | | Critical Residues | P8 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR; CD; ITC | | Interaction ID | 21767 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19921743 | | Comments | The SH3 domain-binding motif in human SHANK2 that binds the murine cortactin SH3 domain |
Record No : 180 |
| Instance ID | 11778 | | Regular Expression | PxPxPR | | Motif Instance | PSPSPR | | Bait Uniprot Accession | Q8TBC3 | | Bait Uniprot Identifier | SHKB1_HUMAN | | Bait Gene Name | SHKBP1 | | Sequence Position | 621-626 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21778 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286, 11152963 | | Comments | A novel polyproline-arginine motif (PXXXPR) in human SH3KBP1-binding protein 1 that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA) |
Record No : 181 |
| Instance ID | 11779 | | Regular Expression | PxPxPR | | Motif Instance | PSPSPR | | Bait Uniprot Accession | Q6P7W2 | | Bait Uniprot Identifier | SHKB1_MOUSE | | Bait Gene Name | Shkbp1 | | Sequence Position | 618-623 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21779 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286, 11152963 | | Comments | A novel polyproline-arginine motif (PXXXPR) [618-623] in mouse SETA-binding protein 1 that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA) |
Record No : 182 |
| Instance ID | 11780 | | Regular Expression | PxPxPR | | Motif Instance | PTPAPR | | Bait Uniprot Accession | Q6P7W2 | | Bait Uniprot Identifier | SHKB1_MOUSE | | Bait Gene Name | Shkbp1 | | Sequence Position | 678-683 | | Critical Residues | P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21780 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12874286, 11152963 | | Comments | A novel polyproline-arginine motif (PXXXPR) [678-683] in mouse SETA-binding protein 1 that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA) |
Record No : 183 |
| Instance ID | 11803 | | Regular Expression | [LI]xCxE | | Motif Instance | LTCEE | | Bait Uniprot Accession | Q3TKT4 | | Bait Uniprot Identifier | SMCA4_MOUSE | | Bait Gene Name | Smarca4 | | Sequence Position | 1324-1328 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21803 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 7923370 | | Comments | The Rb-binding LXCXE motif of the mouse Transcription activator BRG1 that is necessary for binding to the mouse Retinoblastoma-associated protein (Rb1) |
Record No : 184 |
| Instance ID | 11804 | | Regular Expression | [LI]xCxE | | Motif Instance | LTCEE | | Bait Uniprot Accession | P51532 | | Bait Uniprot Identifier | SMCA4_HUMAN | | Bait Gene Name | SMARCA4 | | Sequence Position | 1357-1361 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21804 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8657132, 7923370 | | Comments | The Rb-binding LXCXE motif of the human Transcription activator BRG1 that is necessary for binding to the human Retinoblastoma-associated protein (RB1) |
Record No : 185 |
| Instance ID | 11823 | | Regular Expression | NITVK | | Motif Instance | NITVK | | Bait Uniprot Accession | P16952 | | Bait Uniprot Identifier | SSP5_STRGN | | Bait Gene Name | ssp5 | | Sequence Position | 1182-1186 | | Critical Residues | P1; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Beta sheet | | Experimental Method(s) | Site-directed mutagenesis | | Interaction ID | 21823 | | Interacting Domain | Unknown | | Disease Association(s) | Periodontitis | | Inhibitor(s) | Unknown | | Reference(s) | 11500450, 15972485 | | Comments | NITVK motif of the cell surface protein SspB of Streptococcus gordonii that is required for binding the Mfa1 major structural subunit protein of the short fimbriae of Porphyromonas gingivalisis for coadhesion and biofilm development between these organisms |
Record No : 186 |
| Instance ID | 11824 | | Regular Expression | VxxLL | | Motif Instance | VQDLL | | Bait Uniprot Accession | P16952 | | Bait Uniprot Identifier | SSP5_STRGN | | Bait Gene Name | ssp5 | | Sequence Position | 1174-1178 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Competitive inhibition of P. gingivalis adherence and biofilm formation by synthetic peptide | | Interaction ID | 21824 | | Interacting Domain | Unknown | | Disease Association(s) | Periodontitis | | Inhibitor(s) | Unknown | | Reference(s) | 18474648, 15972485 | | Comments | The VxxLL region of the cell surface protein SspB of Streptococcus gordonii that contributes to its interaction with the Mfa1 major structural subunit protein of the short fimbriae of Porphyromonas gingivalisis for coadhesion and biofilm development between these organisms |
Record No : 187 |
| Instance ID | 11831 | | Regular Expression | R[ST][ST]SL | | Motif Instance | RTSSL | | Bait Uniprot Accession | C7GQJ8 | | Bait Uniprot Identifier | C7GQJ8_YEAS2 | | Bait Gene Name | STE5 | | Sequence Position | 117-121 | | Critical Residues | P1; P2; P4; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay; Mutational analysis | | Interaction ID | 21831 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18280496 | | Comments | The consensus R[ST][ST]SL motif in Ste5p of Saccharomyces cerevisiae (strain JAY291) that is necessary, but not sufficient for binding to the Fus1p SH3 domain |
Record No : 188 |
| Instance ID | 11838 | | Regular Expression | ISxPx{2,4}FxHxxHVGxD | | Motif Instance | ISTPYNAKHIHHVGVD | | Bait Uniprot Accession | Q03497 | | Bait Uniprot Identifier | STE20_YEAST | | Bait Gene Name | STE20 | | Sequence Position | 337-352 | | Critical Residues | P2; P9; P12 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21838 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11940652, 12586692, 9601050, 7493928 | | Comments | The Cdc42/Rac interactive binding (CRIB) motif in the Saccharomyces cerevisiae kinase Ste20 that forms a minimal consensus for functionally interacting with Cdc42 in a GTP-dependent manner |
Record No : 189 |
| Instance ID | 11842 | | Regular Expression | PPGx[RK] | | Motif Instance | PPGMR | | Bait Uniprot Accession | P14678 | | Bait Uniprot Identifier | RSMB_HUMAN | | Bait Gene Name | SNRPB | | Sequence Position | 192-196 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR shift mapping; SPOT Analysis | | Interaction ID | 21842 | | Interacting Domain | GYF domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15105431, 16000308 | | Comments | Proline-rich sequences (192-196) in human Small nuclear ribonucleoprotein-associated proteins B and B' that serves as a recognition motif for the GYF domain of the cellular adapter protein CD2BP2 |
Record No : 190 |
| Instance ID | 11843 | | Regular Expression | PPGx[RK] | | Motif Instance | PPGMR | | Bait Uniprot Accession | P14678 | | Bait Uniprot Identifier | RSMB_HUMAN | | Bait Gene Name | SNRPB | | Sequence Position | 217-221 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR shift mapping; SPOT Analysis | | Interaction ID | 21843 | | Interacting Domain | GYF domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15105431, 16000308 | | Comments | Proline-rich sequences (217-221) in human Small nuclear ribonucleoprotein-associated proteins B and B' that serves as a recognition motif for the GYF domain of the cellular adapter protein CD2BP2 |
Record No : 191 |
| Instance ID | 11844 | | Regular Expression | PPGx[RK] | | Motif Instance | PPGMR | | Bait Uniprot Accession | P14678 | | Bait Uniprot Identifier | RSMB_HUMAN | | Bait Gene Name | SNRPB | | Sequence Position | 224-228 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | NMR shift mapping; SPOT Analysis | | Interaction ID | 21844 | | Interacting Domain | GYF domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15105431, 16000308 | | Comments | Proline-rich sequences (224-228) in human Small nuclear ribonucleoprotein-associated proteins B and B' that serves as a recognition motif for the GYF domain of the cellular adapter protein CD2BP2 |
Record No : 192 |
| Instance ID | 11849 | | Regular Expression | FGPxL | | Motif Instance | FGPAL | | Bait Uniprot Accession | Q96FS4 | | Bait Uniprot Identifier | SIPA1_HUMAN | | Bait Gene Name | SIPA1 | | Sequence Position | 486-490 | | Critical Residues | P1; P2; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | PPII helix | | Experimental Method(s) | Phage Display; SPOT Analysis | | Interaction ID | 21849 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15845542 | | Comments | The consensus motif in human Signal-induced proliferation-associated protein 1 that represent putative target sites for binding of Cyclophilin A, a peptidyl-prolyl cis/trans-isomerase that is involved in multiple signaling events of eukaryotic cells |
Record No : 193 |
| Instance ID | 11858 | | Regular Expression | [ND]xY[ST]xxP | | Motif Instance | NEYTEGP | | Bait Uniprot Accession | O43597 | | Bait Uniprot Identifier | SPY2_HUMAN | | Bait Gene Name | SPRY2 | | Sequence Position | 53-59 | | Critical Residues | P1; P3; P7 | | Motif PTM(s) | Phosphorylation at Tyr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis | | Interaction ID | 21858 | | Interacting Domain | TKB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12815057 | | Comments | Consensus sequence for phosphotyrosine recognition by the c-Cbl TKB domain in human protein Sprouty homolog 2 and this high affinity interaction is critical for its physiological function in a signal-specific context |
Record No : 194 |
| Instance ID | 11859 | | Regular Expression | NxY[STEQ] | | Motif Instance | NEYT | | Bait Uniprot Accession | P12931 | | Bait Uniprot Identifier | SRC_HUMAN | | Bait Gene Name | SRC | | Sequence Position | 417-420 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Tyr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Sequence based prediction | | Interaction ID | 21859 | | Interacting Domain | TKB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15737992, 11448952 | | Comments | Consensus sequence for phosphotyrosine recognition by the Cbl TKB domain in human Proto-oncogene tyrosine-protein kinase Src where c-Cbl acts as a ubiquitin ligase thus down-regulating Src |
Record No : 195 |
| Instance ID | 11861 | | Regular Expression | NxY[STEQ] | | Motif Instance | NPYE | | Bait Uniprot Accession | P43405 | | Bait Uniprot Identifier | KSYK_HUMAN | | Bait Gene Name | SYK | | Sequence Position | 321-324 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Tyr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutational analysis; Competition binding assay | | Interaction ID | 21861 | | Interacting Domain | TKB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15737992, 9857068 | | Comments | Consensus sequence for phosphotyrosine recognition by the Cbl TKB domain in human Tyrosine-protein kinase SYK that plays a critical role in the recruitment of Cbl to Syk and in Cbl-mediated negative regulation of Syk |
Record No : 196 |
| Instance ID | 11863 | | Regular Expression | RA[VI]xNQY[ST] | | Motif Instance | RAVENQYS | | Bait Uniprot Accession | O14492 | | Bait Uniprot Identifier | SH2B2_HUMAN | | Bait Gene Name | SH2B2 | | Sequence Position | 623-630 | | Critical Residues | P1; P2; P3; P5; P7 | | Motif PTM(s) | Phosphorylation at Tyr-P7 | | Secondary Structure | Extended conformation | | Experimental Method(s) | X-ray crystallography; Site-directed mutagenesis; ITC | | Interaction ID | 21863 | | Interacting Domain | TKB domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15737992 | | Comments | Novel Cbl phosphotyrosine recognition motif in SH2B adapter protein 2 (APS) that serves as a binding site for the Cbl TKB domain and allows Cbl ito be recruited to and phosphorylated by the insulin receptor in adipose cells through the adapter protein APS |
Record No : 197 |
| Instance ID | 11943 | | Regular Expression | Y[VI]N | | Motif Instance | YVN | | Bait Uniprot Accession | P29353 | | Bait Uniprot Identifier | SHC1_HUMAN | | Bait Gene Name | SHC1 | | Sequence Position | 427-429 | | Critical Residues | P1 | | Motif PTM(s) | Phosphorylation at Tyr-P1 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding assay | | Interaction ID | 21943 | | Interacting Domain | SH2 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 8491186 | | Comments | The short sequence motif present in SHC-transforming protein 1 that specifically binds the SH2 domain of Growth factor receptor-bound protein 2 with high affinity |
Record No : 198 |
| Instance ID | 11966 | | Regular Expression | PxxxRxxKP | | Motif Instance | PVVDRSLKP | | Bait Uniprot Accession | Q9CQ26 | | Bait Uniprot Identifier | STABP_MOUSE | | Bait Gene Name | Stambp | | Sequence Position | 231-239 | | Critical Residues | P5; P8 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | SPOT Analysis | | Interaction ID | 21966 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12176364 | | Comments | The high-affinity atypical R-X-X-K binding motif in mouse STAM-binding protein for binding the Gads SH3 Domain |
Record No : 199 |
| Instance ID | 11974 | | Regular Expression | NxI | | Motif Instance | NAI | | Bait Uniprot Accession | Q9BQB4 | | Bait Uniprot Identifier | SOST_HUMAN | | Bait Gene Name | SOST | | Sequence Position | 117-119 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Mutational analysis; Competition binding assay; BLI; ELISA | | Interaction ID | 21974 | | Interacting Domain | E1 domain | | Disease Association(s) | Bone dysplasia | | Inhibitor(s) | Unknown | | Reference(s) | 21944579 | | Comments | The NxI peptide motif in the Wnt pathway inhibitor Sclerostin (SOST) that is important for binding to the E1 propeller domain of Wnt coreceptor LRP6 and for inhibitory function |
Record No : 200 |
| Instance ID | 11975 | | Regular Expression | NxI | | Motif Instance | NWI | | Bait Uniprot Accession | Q6X4U4 | | Bait Uniprot Identifier | SOSD1_HUMAN | | Bait Gene Name | SOSTDC1 | | Sequence Position | 112-114 | | Critical Residues | P1; P3 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; ELISA | | Interaction ID | 21975 | | Interacting Domain | E1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 21944579, 12900447 | | Comments | The NxI peptide motif in the Wnt pathway inhibitor WISE (SOSTDC1) that is important for binding to the E1 propeller domain of Wnt coreceptor LRP6 |
Record No : 201 |
| Instance ID | 11993 | | Regular Expression | PPxY | | Motif Instance | PPRY | | Bait Uniprot Accession | P08363 | | Bait Uniprot Identifier | VP8_BTV10 | | Bait Gene Name | S10 | | Sequence Position | 36-39 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 21993 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16352570 | | Comments | Non-structural protein NS3 (S10) of Bluetongue virus (BTV) harbors a PPXY late-domain motif that allows NS3 to bind Human NEDD4-like E3 ubiquitin-protein ligase WWP1 |
Record No : 202 |
| Instance ID | 11994 | | Regular Expression | PPxY | | Motif Instance | PPRY | | Bait Uniprot Accession | P08363 | | Bait Uniprot Identifier | VP8_BTV10 | | Bait Gene Name | S10 | | Sequence Position | 36-39 | | Critical Residues | P1; P2 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 21994 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16352570 | | Comments | Non-structural protein NS3 (S10) of Bluetongue virus (BTV) harbors a PPXY late-domain motif that allows NS3 to bind Human E3 ubiquitin-protein ligase Itchy homolog (ITCH) |
Record No : 203 |
| Instance ID | 12011 | | Regular Expression | LxHxTxxRPKx{6,6}P | | Motif Instance | LSHPTTSRPKATGRRPP | | Bait Uniprot Accession | Q96B97 | | Bait Uniprot Identifier | SH3K1_HUMAN | | Bait Gene Name | SH3KBP1 | | Sequence Position | 476-492 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Competition binding | | Interaction ID | 22011 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16707503, 12690097 | | Comments | The motif present in human CIN85/SH3KBP1 that is sufficient for binding to human F-actin-capping protein subunit alpha-1 (CapZ alpha-1) |
Record No : 204 |
| Instance ID | 12012 | | Regular Expression | LxHxTxxRPKx{6,6}P | | Motif Instance | LSHPTTSRPKATGRRPP | | Bait Uniprot Accession | Q96B97 | | Bait Uniprot Identifier | SH3K1_HUMAN | | Bait Gene Name | SH3KBP1 | | Sequence Position | 476-492 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Competition binding | | Interaction ID | 22012 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16707503, 12690097 | | Comments | The motif present in human CIN85/SH3KBP1 that is sufficient for binding to human F-actin-capping protein subunit alpha-2 (CapZ alpha-2) |
Record No : 205 |
| Instance ID | 12013 | | Regular Expression | LxHxTxxRPKx{6,6}P | | Motif Instance | LSHPTTSRPKATGRRPP | | Bait Uniprot Accession | Q96B97 | | Bait Uniprot Identifier | SH3K1_HUMAN | | Bait Gene Name | SH3KBP1 | | Sequence Position | 476-492 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction; Competition binding | | Interaction ID | 22013 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16707503, 12690097 | | Comments | The motif present in human CIN85/SH3KBP1 that is sufficient for binding to human F-actin-capping protein subunit beta (CapZ beta) |
Record No : 206 |
| Instance ID | 12043 | | Regular Expression | FxxxVQxLTG | | Motif Instance | FRELVQELTG | | Bait Uniprot Accession | Q9LDH1 | | Bait Uniprot Identifier | SIB1_ARATH | | Bait Gene Name | SIB1 | | Sequence Position | 58-67 | | Critical Residues | P5; P6 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 22043 | | Interacting Domain | WRKY domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22535423, 21990940 | | Comments | The VQ-motif in Sigma factor binding protein 1 (SIB1) of Arabidopsis thaliana that interacts specifically with the C-terminal WRKY domain of Arabidopsis WRKY transcription factor 33 (WRKY33) |
Record No : 207 |
| Instance ID | 12044 | | Regular Expression | FxxxVQxLTG | | Motif Instance | FRELVQELTG | | Bait Uniprot Accession | O80669 | | Bait Uniprot Identifier | SIB2_ARATH | | Bait Gene Name | SIB2 | | Sequence Position | 55-64 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H | | Interaction ID | 22044 | | Interacting Domain | WRKY domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22535423, 21990940 | | Comments | The VQ-motif in Sigma factor binding protein 2 (SIB2) of Arabidopsis thaliana that interacts specifically with the C-terminal WRKY domain of Arabidopsis WRKY transcription factor 33 (WRKY33) |
Record No : 208 |
| Instance ID | 12058 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | SKEAYI | | Bait Uniprot Accession | P31648 | | Bait Uniprot Identifier | SC6A1_MOUSE | | Bait Gene Name | Slc6a1 | | Sequence Position | 594-599 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down | | Interaction ID | 22058 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25305483 | | Comments | C-terminal class 1 PDZ-binding motif in mouse Sodium- and chloride-dependent GABA transporter 1 (Slc6a1) that binds to the PDZ domains of mouse Multiple PDZ domain protein (Mpdz) |
Record No : 209 |
| Instance ID | 12059 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | EKETHL | | Bait Uniprot Accession | P31651 | | Bait Uniprot Identifier | S6A12_MOUSE | | Bait Gene Name | Slc6a12 | | Sequence Position | 609-614 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down | | Interaction ID | 22059 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25305483 | | Comments | C-terminal class 1 PDZ-binding motif in mouse Sodium- and chloride-dependent GABA transporter 2 (Slc6a12) that binds to the PDZ domains of mouse Multiple PDZ domain protein (Mpdz) |
Record No : 210 |
| Instance ID | 12060 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | EKETHF | | Bait Uniprot Accession | P31650 | | Bait Uniprot Identifier | S6A11_MOUSE | | Bait Gene Name | Slc6a11 | | Sequence Position | 622-627 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down | | Interaction ID | 22060 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25305483 | | Comments | C-terminal class 1 PDZ-binding motif in mouse Sodium- and chloride-dependent GABA transporter 3 (Slc6a11) that binds to the PDZ domains of mouse Multiple PDZ domain protein (Mpdz) |
Record No : 211 |
| Instance ID | 12061 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | FQDSRI | | Bait Uniprot Accession | P28571 | | Bait Uniprot Identifier | SC6A9_MOUSE | | Bait Gene Name | Slc6a9 | | Sequence Position | 687-692 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down | | Interaction ID | 22061 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25305483 | | Comments | C-terminal class 1 PDZ-binding motif in mouse Sodium- and chloride-dependent glycine transporter 1 (Slc6a9) that binds to the PDZ domains of mouse Multiple PDZ domain protein (Mpdz) |
Record No : 212 |
| Instance ID | 12062 | | Regular Expression | xxx[ST]x[ACVILF]$ | | Motif Instance | ELGTQC | | Bait Uniprot Accession | Q761V0 | | Bait Uniprot Identifier | SC6A5_MOUSE | | Bait Gene Name | Slc6a5 | | Sequence Position | 794-799 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Pull down | | Interaction ID | 22062 | | Interacting Domain | PDZ domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25305483 | | Comments | C-terminal class 1 PDZ-binding motif in mouse Sodium- and chloride-dependent glycine transporter 2 (Slc6a5) that binds to the PDZ domains of mouse Multiple PDZ domain protein (Mpdz) |
Record No : 213 |
| Instance ID | 12063 | | Regular Expression | PxxPx[KR] | | Motif Instance | PPPPVR | | Bait Uniprot Accession | Q62634 | | Bait Uniprot Identifier | VGLU1_RAT | | Bait Gene Name | Slc17a7 | | Sequence Position | 553-558 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22063 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25334008 | | Comments | The second SH3 domain of Rat actin cytoskeletal adaptor protein Nck1 binds to a proline-rich sequence present in the C terminus of Rat Vesicular glutamate transporter 1 (VGluT1) or Slc17a7 |
Record No : 214 |
| Instance ID | 12064 | | Regular Expression | PxxPx[KR] | | Motif Instance | PPPPVR | | Bait Uniprot Accession | Q62634 | | Bait Uniprot Identifier | VGLU1_RAT | | Bait Gene Name | Slc17a7 | | Sequence Position | 553-558 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22064 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25334008 | | Comments | The SH3 domain of Rat Sorbin and SH3 domain-containing protein 1 (Sorbs1) or Ponsin binds to a proline-rich sequence present in the C terminus of Rat Vesicular glutamate transporter 1 (VGluT1) or Slc17a7 |
Record No : 215 |
| Instance ID | 12065 | | Regular Expression | PxxPx[KR] | | Motif Instance | PPPPVR | | Bait Uniprot Accession | Q62634 | | Bait Uniprot Identifier | VGLU1_RAT | | Bait Gene Name | Slc17a7 | | Sequence Position | 553-558 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Disordered | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22065 | | Interacting Domain | SH3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25334008 | | Comments | The SH3 domain of Rat Tyrosine-protein kinase Lyn binds to a proline-rich sequence present in the C terminus of Rat Vesicular glutamate transporter 1 (VGluT1) or Slc17a7 |
Record No : 216 |
| Instance ID | 12066 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | Q62634 | | Bait Uniprot Identifier | VGLU1_RAT | | Bait Gene Name | Slc17a7 | | Sequence Position | 538-541 | | Critical Residues | P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22066 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25334008 | | Comments | The PPXY motif of Rat Vesicular glutamate transporter 1 (VGluT1) or Slc17a7 that binds to the WW domain of Rat HECT domain E3 ubiquitin ligase Atrophin Interacting Protein AIP4/Itch |
Record No : 217 |
| Instance ID | 12067 | | Regular Expression | PPxY | | Motif Instance | PPSY | | Bait Uniprot Accession | Q62634 | | Bait Uniprot Identifier | VGLU1_RAT | | Bait Gene Name | Slc17a7 | | Sequence Position | 538-541 | | Critical Residues | P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22067 | | Interacting Domain | WW domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 25334008 | | Comments | The PPXY motif of Rat Vesicular glutamate transporter 1 (VGluT1) or Slc17a7 that binds to the WW domain of Rat E3 ubiquitin-protein ligase Nedd4 |
Record No : 218 |
| Instance ID | 12142 | | Regular Expression | [KRHN][SVIL]x[FXY] | | Motif Instance | KLDY | | Bait Uniprot Accession | Q14160 | | Bait Uniprot Identifier | SCRIB_HUMAN | | Bait Gene Name | SCRIB | | Sequence Position | 1265-1268 | | Critical Residues | P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22142 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23359326 | | Comments | PP1-binding motif of human Protein Scribble (SCRIB) that binds to human protein phosphatase PP1-gamma catalytic subunit (PPP1CC) |
Record No : 219 |
| Instance ID | 12146 | | Regular Expression | GxxxxGK[TS] | | Motif Instance | GPVRTGKS | | Bait Uniprot Accession | Q182W3 | | Bait Uniprot Identifier | SP4A_PEPD6 | | Bait Gene Name | spoIVA | | Sequence Position | 23-30 | | Critical Residues | P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Affinity purification | | Interaction ID | 22146 | | Interacting Domain | LysM domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23292781 | | Comments | The Walker A ATP-binding motif in Stage IV sporulation protein A (SpoIVA) of Clostridium difficile interacts with the LysM domain of Spore coat protein SipL |
Record No : 220 |
| Instance ID | 12159 | | Regular Expression | GS[QR]TPx[YQ] | | Motif Instance | GSRTPMY | | Bait Uniprot Accession | O00267 | | Bait Uniprot Identifier | SPT5H_HUMAN | | Bait Gene Name | SUPT5H | | Sequence Position | 781-787 | | Critical Residues | P4 | | Motif PTM(s) | Phosphorylation at Thr-P4 | | Secondary Structure | Disordered | | Experimental Method(s) | X-ray crystallography | | Interaction ID | 22159 | | Interacting Domain | Plus3 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24101474 | | Comments | The Plus3 domain of human RNA polymerase-associated protein RTF1 recognizes and binds to the C-terminal repeat (CTR) motif of human Transcription elongation factor SPT5 |
Record No : 221 |
| Instance ID | 12160 | | Regular Expression | FYSPPE | | Motif Instance | FYSPPE | | Bait Uniprot Accession | Q14849 | | Bait Uniprot Identifier | STAR3_HUMAN | | Bait Gene Name | STARD3 | | Sequence Position | 207-212 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 22160 | | Interacting Domain | MSP domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24105263 | | Comments | FFAT-like motif in human StAR-related lipid transfer protein 3 (STARD3) that allows it to interact directly with the MSP domain of human Vesicle-associated membrane protein-associated protein A (VAPA) |
Record No : 222 |
| Instance ID | 12161 | | Regular Expression | FYSPPE | | Motif Instance | FYSPPE | | Bait Uniprot Accession | Q14849 | | Bait Uniprot Identifier | STAR3_HUMAN | | Bait Gene Name | STARD3 | | Sequence Position | 207-212 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 22161 | | Interacting Domain | MSP domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24105263 | | Comments | FFAT-like motif in human StAR-related lipid transfer protein 3 (STARD3) that allows it to interact directly with the MSP domain of human Vesicle-associated membrane protein-associated protein B/C (VAPB) |
Record No : 223 |
| Instance ID | 12162 | | Regular Expression | FYSPPE | | Motif Instance | FYSPPE | | Bait Uniprot Accession | O95772 | | Bait Uniprot Identifier | MENTO_HUMAN | | Bait Gene Name | STARD3NL | | Sequence Position | 208-213 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 22162 | | Interacting Domain | MSP domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24105263 | | Comments | FFAT-like motif in human STARD3 N-terminal-like protein/MLN64 N-terminal domain homolog (STARD3NL/MENTHO) that allows it to interact directly with the MSP domain of human Vesicle-associated membrane protein-associated protein A (VAPA) |
Record No : 224 |
| Instance ID | 12164 | | Regular Expression | [LIVY]R[KRW][RKL]Rxxx[FKLY] | | Motif Instance | LRRRRLQKL | | Bait Uniprot Accession | Q86TM6 | | Bait Uniprot Identifier | SYVN1_HUMAN | | Bait Gene Name | SYVN1 | | Sequence Position | 603-611 | | Critical Residues | P2; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Mutation analysis; Co-IP; Pull down(GST tag); NMR; ITC | | Interaction ID | 22164 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24100225 | | Comments | The VCP-binding motif (VBM) in Human E3 ubiquitin-protein ligase synoviolin (SYVN1) that is critical for binding to human Transitional endoplasmic reticulum ATPase VCP |
Record No : 225 |
| Instance ID | 12165 | | Regular Expression | Rx{0,3}AxAAxxR | | Motif Instance | RAKLAEAAERR | | Bait Uniprot Accession | P0C0A9 | | Bait Uniprot Identifier | SVIP_RAT | | Bait Gene Name | Svip | | Sequence Position | 22-32 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Coil | | Experimental Method(s) | Sequence based prediction; Pull down(GST tag) | | Interaction ID | 22165 | | Interacting Domain | ND1 domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12529442 | | Comments | The VCP-interacting motif (VIM) in rat Small VCP/p97-interacting protein (Svip) that mediates interaction with rat Transitional endoplasmic reticulum ATPase (Vcp) |
Record No : 226 |
| Instance ID | 12194 | | Regular Expression | KKKK | | Motif Instance | KKKK | | Bait Uniprot Accession | P21707 | | Bait Uniprot Identifier | SYT1_RAT | | Bait Gene Name | Syt1 | | Sequence Position | 324-327 | | Critical Residues | P1; P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Pull down(GST tag) | | Interaction ID | 22194 | | Interacting Domain | Unknown | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 24472545 | | Comments | The polylysine KKKK motif in rat Synaptotagmin I (Syt1) that is responsible for interaction with rat Ras-related protein Rab3a |
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