Total : 226 Records


Record No : 1

Instance ID10034
Regular ExpressionRxx[^P]([ST])[IVLM]x
Motif InstanceRKAVSMH
Bait Uniprot AccessionP32418
Bait Uniprot IdentifierNAC1_HUMAN
Bait Gene NameSLC8A1
Sequence Position388-394
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down
Interaction ID20034
Interacting Domain14-3-3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16679322
Comments14-3-3 binding site in Sodium/calcium exchange protein 1 that binds to 14-3-3 protein epsilon, which may modulate their calcium extrusion activity

Record No : 2

Instance ID10035
Regular ExpressionRxx[^P]([ST])[IVLM]x
Motif InstanceRKAVSMH
Bait Uniprot AccessionP32418
Bait Uniprot IdentifierNAC1_HUMAN
Bait Gene NameSLC8A1
Sequence Position388-394
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down
Interaction ID20035
Interacting Domain14-3-3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16679322
Comments14-3-3 binding site in Sodium/calcium exchange protein 1 that binds to 14-3-3 protein zeta, which may modulate their calcium extrusion activity

Record No : 3

Instance ID10036
Regular ExpressionRxx[^P]([ST])[IVLM]x
Motif InstanceRKAVSMH
Bait Uniprot AccessionP32418
Bait Uniprot IdentifierNAC1_HUMAN
Bait Gene NameSLC8A1
Sequence Position388-394
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down
Interaction ID20036
Interacting Domain14-3-3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16679322
Comments14-3-3 binding site in Sodium/calcium exchange protein 1 that binds to 14-3-3 protein beta, which may modulate their calcium extrusion activity

Record No : 4

Instance ID10037
Regular ExpressionRxx[^P]([ST])[IVLM]x
Motif InstanceRKAVSMH
Bait Uniprot AccessionP32418
Bait Uniprot IdentifierNAC1_HUMAN
Bait Gene NameSLC8A1
Sequence Position388-394
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down
Interaction ID20037
Interacting Domain14-3-3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16679322
Comments14-3-3 binding site in Sodium/calcium exchange protein 1 that binds to 14-3-3 protein theta, which may modulate their calcium extrusion activity

Record No : 5

Instance ID10041
Regular Expression[RHK][STALV]x([ST])x[PESRDIFTQ]
Motif InstanceRSNSAI
Bait Uniprot AccessionQ8IPH9
Bait Uniprot IdentifierSLOB_DROME
Bait Gene NameSlob
Sequence Position51-56
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Co-IP
Interaction ID20041
Interacting Domain14-3-3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10230800
Comments14-3-3 binding motif (pS-54) in Drosophila Slowpoke-binding protein (Slob) that binds to 14-3-3 protein zeta

Record No : 6

Instance ID10042
Regular Expression[RHK][STALV]x([ST])x[PESRDIFTQ]
Motif InstanceRSASSE
Bait Uniprot AccessionQ8IPH9
Bait Uniprot IdentifierSLOB_DROME
Bait Gene NameSlob
Sequence Position76-81
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Co-IP
Interaction ID20042
Interacting Domain14-3-3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10230800
Comments14-3-3 binding motif (pS-79) in Drosophila Slowpoke-binding protein (Slob) that binds to 14-3-3 protein zeta

Record No : 7

Instance ID10089
Regular Expression[R]xx[ILVMF][ILMVF][^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATI]
Motif InstanceREQLMESIRKGKELKQI
Bait Uniprot AccessionQ9U1K1
Bait Uniprot IdentifierSPIR_DROME
Bait Gene Namespir
Sequence Position464-480
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; Sequence based prediction; Affinity chromatography technology; Electron microscopy; Pull down; Alanine scanning; NMR; Classical fluorescence spectroscopy; structure based prediction; Molecular sieving
Interaction ID20089
Interacting DomainHydrophobic cleft formed by subdomains 1 and 3
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10556052, 15674283, 20538977
CommentsWH2 motif (464-480) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of Drosophila Actin-5C

Record No : 8

Instance ID10090
Regular Expression[R]xx[ILVMF][ILMVF][^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATI]
Motif InstanceREQLMESIRKGKELKQI
Bait Uniprot AccessionQ9U1K1
Bait Uniprot IdentifierSPIR_DROME
Bait Gene Namespir
Sequence Position464-480
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; Sequence based prediction; Affinity chromatography technology; Electron microscopy; Pull down; Alanine scanning; NMR; Classical fluorescence spectroscopy; structure based prediction; Molecular sieving
Interaction ID20090
Interacting DomainHydrophobic cleft formed by subdomains 1 and 3
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10556052, 15674283, 20538977
CommentsWH2 motif (464-480) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1

Record No : 9

Instance ID10091
Regular Expression[R]xx[ILVMF][ILMVF][^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATI]
Motif InstanceREQLMESIRKGKELKQI
Bait Uniprot AccessionQ9U1K1
Bait Uniprot IdentifierSPIR_DROME
Bait Gene Namespir
Sequence Position464-480
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; Sequence based prediction; Affinity chromatography technology; Electron microscopy; Pull down; Alanine scanning; NMR; Classical fluorescence spectroscopy; structure based prediction; Molecular sieving
Interaction ID20091
Interacting DomainHydrophobic cleft formed by subdomains 1 and 3
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10556052, 15674283, 20538977
CommentsWH2 motif (464-480) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of chicken Alpha-actin-1

Record No : 10

Instance ID10092
Regular Expression[R]xx[ILVMF][ILMVF][^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATI]
Motif InstanceREQLMESIRKGKELKQI
Bait Uniprot AccessionQ9U1K1
Bait Uniprot IdentifierSPIR_DROME
Bait Gene Namespir
Sequence Position464-480
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; Sequence based prediction; Affinity chromatography technology; Electron microscopy; Pull down; Alanine scanning; NMR; Classical fluorescence spectroscopy; structure based prediction; Molecular sieving
Interaction ID20092
Interacting DomainHydrophobic cleft formed by subdomains 1 and 3
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10556052, 15674283, 20538977
CommentsWH2 motif (464-480) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of Acanthamoeba Actin-1

Record No : 11

Instance ID10102
Regular Expression[^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS]
Motif InstanceHAMILEFIRSRPPLKKA
Bait Uniprot AccessionQ9U1K1
Bait Uniprot IdentifierSPIR_DROME
Bait Gene Namespir
Sequence Position432-448
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Affinity chromatography technology; Mutation analysis; Electron microscopy; Pull down; Alanine scanning
Interaction ID20102
Interacting DomainHydrophobic cleft formed by subdomains 1 and 3
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15674283
CommentsWH2 motif (432-448) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of Acanthamoeba Actin-1

Record No : 12

Instance ID10103
Regular Expression[^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS]
Motif InstanceYEILMGDIRAKKYQLRKV
Bait Uniprot AccessionQ9U1K1
Bait Uniprot IdentifierSPIR_DROME
Bait Gene Namespir
Sequence Position400-417
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; Sequence based prediction; Affinity chromatography technology; Electron microscopy; Pull down; Alanine scanning; Classical fluorescence spectroscopy; structure based prediction; Molecular sieving; NMR
Interaction ID20103
Interacting DomainHydrophobic cleft formed by subdomains 1 and 3
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10556052, 15674283, 20538977
CommentsWH2 motif (400-417) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of Drosophila Actin-5C

Record No : 13

Instance ID10104
Regular Expression[^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS]
Motif InstanceYEILMGDIRAKKYQLRKV
Bait Uniprot AccessionQ9U1K1
Bait Uniprot IdentifierSPIR_DROME
Bait Gene Namespir
Sequence Position400-417
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; Sequence based prediction; Affinity chromatography technology; Electron microscopy; Pull down; Alanine scanning; Classical fluorescence spectroscopy; structure based prediction; Molecular sieving; NMR
Interaction ID20104
Interacting DomainHydrophobic cleft formed by subdomains 1 and 3
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10556052, 15674283, 20538977
CommentsWH2 motif (400-417) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1

Record No : 14

Instance ID10105
Regular Expression[^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS]
Motif InstanceYEILMGDIRAKKYQLRKV
Bait Uniprot AccessionQ9U1K1
Bait Uniprot IdentifierSPIR_DROME
Bait Gene Namespir
Sequence Position400-417
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; Sequence based prediction; Affinity chromatography technology; Electron microscopy; Pull down; Alanine scanning; Classical fluorescence spectroscopy; structure based prediction; Molecular sieving; NMR
Interaction ID20105
Interacting DomainHydrophobic cleft formed by subdomains 1 and 3
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10556052, 15674283, 20538977
CommentsWH2 motif (400-417) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of chicken Alpha-actin-1

Record No : 15

Instance ID10106
Regular Expression[^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS]
Motif InstanceYEILMGDIRAKKYQLRKV
Bait Uniprot AccessionQ9U1K1
Bait Uniprot IdentifierSPIR_DROME
Bait Gene Namespir
Sequence Position400-417
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; Sequence based prediction; Affinity chromatography technology; Electron microscopy; Pull down; Alanine scanning; Classical fluorescence spectroscopy; structure based prediction; Molecular sieving; NMR
Interaction ID20106
Interacting DomainHydrophobic cleft formed by subdomains 1 and 3
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10556052, 15674283, 20538977
CommentsWH2 motif (400-417) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of Acanthamoeba Actin-1

Record No : 16

Instance ID10107
Regular Expression[^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS]
Motif InstanceWVQVIDELRRGVRLKKS
Bait Uniprot AccessionQ9U1K1
Bait Uniprot IdentifierSPIR_DROME
Bait Gene Namespir
Sequence Position370-386
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Affinity chromatography technology; Mutation analysis; Electron microscopy; Pull down; Alanine scanning
Interaction ID20107
Interacting DomainHydrophobic cleft formed by subdomains 1 and 3
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15674283
CommentsWH2 motif (370-386) in Drosophila protein Spire that binds to the hydrophobic cleft formed by subdomains 1 and 3 of Acanthamoeba Actin-1

Record No : 17

Instance ID10108
Regular Expression[^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS]
Motif InstanceAGDFLHQIRTKQFNLRRV
Bait Uniprot AccessionQ6AWX6
Bait Uniprot IdentifierSCAR1_ARATH
Bait Gene NameSCAR1
Sequence Position757-774
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Western blot; Pull down; Sequence based prediction
Interaction ID20108
Interacting DomainHydrophobic cleft formed by subdomains 1 and 3
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)1529676, 15534215
CommentsThe WH2 motif in Arabidopsis protein SCAR1 that mediates its interaction with the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1

Record No : 18

Instance ID10109
Regular Expression[^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS]
Motif InstanceKDSLLAQIRNKSVNLKPA
Bait Uniprot AccessionQ5XPJ9
Bait Uniprot IdentifierSCAR2_ARATH
Bait Gene NameSCAR2
Sequence Position1336-1353
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Sequence based prediction
Interaction ID20109
Interacting DomainHydrophobic cleft formed by subdomains 1 and 3
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15534215
CommentsThe WH2 motif in Arabidopsis protein SCAR2 that mediates its interaction with the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1

Record No : 19

Instance ID10110
Regular Expression[^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS]
Motif InstanceNDSLLEIIRSKSFNLRPA
Bait Uniprot AccessionQ5XPJ6
Bait Uniprot IdentifierSCAR4_ARATH
Bait Gene NameSCAR4
Sequence Position1106-1123
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Pull down; Sequence based prediction
Interaction ID20110
Interacting DomainHydrophobic cleft formed by subdomains 1 and 3
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15534215
CommentsThe WH2 motif in Arabidopsis protein SCAR4 that mediates its interaction with the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1

Record No : 20

Instance ID10113
Regular Expression[^R]xx((x[ILMVF])|([ILMVF]x))[^P][^P][ILVM]x{4,7}L(([KR]x)|(NK))[VATIGS]
Motif InstanceTGDFLQQIRTQQFNLRPV
Bait Uniprot AccessionQ9LP46
Bait Uniprot IdentifierSCAR3_ARATH
Bait Gene NameSCAR3
Sequence Position955-972
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Pull down; Sequence based prediction
Interaction ID20113
Interacting DomainHydrophobic cleft formed by subdomains 1 and 3
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15534215
CommentsThe WH2 motif in Arabidopsis protein SCAR3 that mediates its interaction with the hydrophobic cleft formed by subdomains 1 and 3 of rabbit Alpha-actin-1

Record No : 21

Instance ID10117
Regular ExpressionFxx[FWY][ST][FY]
Motif InstanceFLGFSY
Bait Uniprot AccessionO00141
Bait Uniprot IdentifierSGK1_HUMAN
Bait Gene NameSGK1
Sequence Position418-423
Critical ResiduesP5
Motif PTM(s)Phosphorylation at Ser-P5
Secondary StructureUnknown
Experimental Method(s)Pull down; Protein kinase assay; Competition binding; Mutation analysis; SPR
Interaction ID20117
Interacting DomainPIF-binding pocket
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11500365
CommentsPhosphorylation of the hydrophobic motif of Serine/threonine-protein kinase Sgk1 promotes its interaction with the PIF-binding pocket of PDK1

Record No : 22

Instance ID10118
Regular ExpressionFxx[FWY][ST][FY]
Motif InstanceFVGFSY
Bait Uniprot AccessionQ96BR1
Bait Uniprot IdentifierSGK3_HUMAN
Bait Gene NameSGK3
Sequence Position482-487
Critical ResiduesP5
Motif PTM(s)Phosphorylation at Ser-P5
Secondary StructureUnknown
Experimental Method(s)Protein kinase assay; Co-IP; Mutation analysis
Interaction ID20118
Interacting DomainPIF-binding pocket
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16790420
CommentsPhosphorylation of the hydrophobic motif of Serine/threonine-protein kinase Sgk3 promotes its interaction with the PIF-binding pocket of PDK1

Record No : 23

Instance ID10119
Regular ExpressionFxx[FWY][ST][FY]
Motif InstanceFAGFTF
Bait Uniprot AccessionP11792
Bait Uniprot IdentifierSCH9_YEAST
Bait Gene NameSCH9
Sequence Position733-738
Critical ResiduesP5
Motif PTM(s)Phosphorylation at Thr-P5
Secondary StructureUnknown
Experimental Method(s)Pull down; Protein kinase assay; Mutation analysis
Interaction ID20119
Interacting DomainPIF-binding pocket
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)21531713
CommentsInteraction of PKH1, the yeast ortholog of mammalian PDK1, with SCH9, the yeast S6K ortholog, depends on the hydrophobic PDK1-interacting fragment (PIF) pocket in PKH1 and requires the complementary hydrophobic motif in SCH9

Record No : 24

Instance ID10120
Regular ExpressionFxx[FWY][ST][FY]
Motif InstanceFVGFSY
Bait Uniprot AccessionQ9ERE3
Bait Uniprot IdentifierSGK3_MOUSE
Bait Gene NameSgk3
Sequence Position482-487
Critical ResiduesP5
Motif PTM(s)Phosphorylation at Ser-P5
Secondary StructureUnknown
Experimental Method(s)Classical fluorescence spectroscopy; Protein kinase assay; Mutation analysis
Interaction ID20120
Interacting DomainPIF-binding pocket
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14604990
CommentsCISK (Sgk3) and PDK-1 interact in a phosphorylation-dependent manner through the hydrophobic motif of Sgk3 and the PIF-binding pocket of PDK1

Record No : 25

Instance ID10131
Regular ExpressionFxDxF
Motif InstanceFGDAF
Bait Uniprot AccessionQ61548
Bait Uniprot IdentifierAP180_MOUSE
Bait Gene NameSnap91
Sequence Position640-644
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Western blot; Co-IP; Pull down(GST tag)
Interaction ID20131
Interacting DomainC-terminal appendage domain of AP-2 subunit alpha-2
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10428863, 12057195
CommentsThe FxDxF motif responsible for the binding of mouse Clathrin coat assembly protein AP180 to the alpha-subunit of adaptor protein AP-2 and its recruitment to the site of clathrin coated vesicle formation

Record No : 26

Instance ID10139
Regular ExpressionDP[FW]
Motif InstanceDPF
Bait Uniprot AccessionQ05140
Bait Uniprot IdentifierAP180_RAT
Bait Gene NameSnap91
Sequence Position400-402
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Far Western blotting; Mutation analysis
Interaction ID20139
Interacting DomainC-terminal appendage domain of AP-2 subunit alpha-2
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10380931, 10944104
CommentsThe DPF/W motif (400-402) of rat Clathrin coat assembly protein AP180 that binds the C-terminal appendage domain of mouse Alpha-adaptin C

Record No : 27

Instance ID10140
Regular ExpressionDP[FW]
Motif InstanceDPF
Bait Uniprot AccessionQ05140
Bait Uniprot IdentifierAP180_RAT
Bait Gene NameSnap91
Sequence Position474-476
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Far Western blotting; Mutation analysis
Interaction ID20140
Interacting DomainC-terminal appendage domain of AP-2 subunit alpha-2
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10380931, 10944104
CommentsThe DPF/W motif (474-476) of rat Clathrin coat assembly protein AP180 that binds the C-terminal appendage domain of mouse Alpha-adaptin C

Record No : 28

Instance ID10153
Regular ExpressionDP[FW]
Motif InstanceDPF
Bait Uniprot AccessionO43426
Bait Uniprot IdentifierSYNJ1_HUMAN
Bait Gene NameSYNJ1
Sequence Position1323-1325
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP; Pull down(GST tag)
Interaction ID20153
Interacting DomainC-terminal appendage domain of AP-2 subunit alpha-1
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10801423
CommentsCharacteristic DPF repeat (1323-1325) in the COOH-terminal domain of human Synaptojanin 1 binds specifically to the C-terminal appendage domain of human Alpha-adaptin C

Record No : 29

Instance ID10154
Regular ExpressionDP[FW]
Motif InstanceDPF
Bait Uniprot AccessionO43426
Bait Uniprot IdentifierSYNJ1_HUMAN
Bait Gene NameSYNJ1
Sequence Position1555-1557
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP; Pull down(GST tag)
Interaction ID20154
Interacting DomainC-terminal appendage domain of AP-2 subunit alpha0
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10801423
CommentsCharacteristic DPF repeat (1555-1557) in the COOH-terminal domain of human Synaptojanin 1 binds specifically to the C-terminal appendage domain of human Alpha-adaptin C

Record No : 30

Instance ID10159
Regular ExpressionxRxxLxx[LIVM]x
Motif InstanceHRKHLQEIP
Bait Uniprot AccessionQ13309
Bait Uniprot IdentifierSKP2_HUMAN
Bait Gene NameSKP2
Sequence Position2-10
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP; Pull down; Radiolabel; Mutation analysis
Interaction ID20159
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15014503
CommentsThe APCC-binding Destruction motif (DBox) due to which the human F-box protein Skp2 is polyubiquitinated, and hence earmarked for destruction, by APC(CDH1)

Record No : 31

Instance ID10201
Regular Expression[DE][DES][DEGAS]F[SGAD][DEAP][LVIMFD]
Motif InstanceDDDFADF
Bait Uniprot AccessionQ9UMZ2
Bait Uniprot IdentifierSYNRG_HUMAN
Bait Gene NameSYNRG
Sequence Position773-779
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; Pull down; Co-IP; Y2H; Classical fluorescence spectroscopy; Colocalization
Interaction ID20201
Interacting DomainGamma adaptin ear (GAE) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12483220, 10477754
CommentsGamma-adaptin ear interaction motif in human Gamma-synergin through which it interacts with Gamma-adaptin

Record No : 32

Instance ID10209
Regular Expression^M{0,1}Ax[AP]x
Motif InstanceMAIPF
Bait Uniprot AccessionQ9VVP8
Bait Uniprot IdentifierQ9VVP8_DROME
Bait Gene Nameskl
Sequence Position1-5
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; Pull down; Mutation analysis
Interaction ID20209
Interacting DomainBIR domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11818063
CommentsIAP-binding motif in Drosophila IAP-inhibitory protein Sickle that binds to the BIR2 domain of Drosophila Iap2 (dIAP2)

Record No : 33

Instance ID10228
Regular ExpressionxW[RK][DE]GCY$
Motif InstanceSWKDGCY
Bait Uniprot AccessionQ9P270
Bait Uniprot IdentifierSLAI2_HUMAN
Bait Gene NameSLAIN2
Sequence Position575-581
Critical ResiduesP7
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Co-IP; ITC; X-ray crystallography
Interaction ID20228
Interacting DomainCAP-Gly domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)21646404
CommentsThe C-Terminal acidic tail of SLAIN2 that is important for the interaction with CLIP-170 in cells

Record No : 34

Instance ID10229
Regular ExpressionL[IVLMF]x[IVLMF][DE]
Motif InstanceLLGLD
Bait Uniprot AccessionQ91VZ6
Bait Uniprot IdentifierSMAP1_MOUSE
Bait Gene NameSmap1
Sequence Position192-196
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Pull down; Mutation analysis; Alanine scanning
Interaction ID20229
Interacting DomainClathrin propeller repeat
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15659652
CommentsClathrin-box-like sequence in the mouse Smap1 protein that interact with the N-terminal beta-propeller structure of Clathrin heavy chain

Record No : 35

Instance ID10243
Regular Expression[DE][DE]xxxVP[DE]
Motif InstanceEEHFLVPD
Bait Uniprot AccessionQ9SID1
Bait Uniprot IdentifierSTH_ARATH
Bait Gene NameSTH
Sequence Position229-236
Critical ResiduesP6; P7
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H
Interaction ID20243
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11226162
CommentsA consensus COP1 binding motif in Arabidopsis Salt tolerance-like protein (STH) that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1

Record No : 36

Instance ID10256
Regular Expression[NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE]
Motif InstanceRKLTDFYPVRRS
Bait Uniprot AccessionQ9NQR1
Bait Uniprot IdentifierSETD8_HUMAN
Bait Gene NameSETD8
Sequence Position220-231
Critical ResiduesP6; P7
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)RNA interference;Western blot; Co-IP; Alanine scanning; Fluorescence technology; Mutation disrupting interaction; Ubiquitinase assay
Interaction ID20256
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)20932472, 21220508
CommentsCDT2-mediated destruction of the histone methyltransferase SETD8 prevents premature chromatin compaction in S phase

Record No : 37

Instance ID10257
Regular Expression[NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE]
Motif InstanceRKLTDFYPVRRS
Bait Uniprot AccessionQ9NQR1
Bait Uniprot IdentifierSETD8_HUMAN
Bait Gene NameSETD8
Sequence Position220-231
Critical ResiduesP6; P7
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)RNA interference;Western blot; Co-IP; Alanine scanning; Fluorescence technology; Mutation disrupting interaction; Ubiquitinase assay
Interaction ID20257
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)20932472, 21220508
CommentsCDT2-mediated destruction of the histone methyltransferase SETD8 prevents premature chromatin compaction in S phase

Record No : 38

Instance ID10267
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLNLS
Bait Uniprot AccessionP35712
Bait Uniprot IdentifierSOX6_HUMAN
Bait Gene NameSOX6
Sequence Position424-428
Critical ResiduesP4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H
Interaction ID20267
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11504872
CommentsThe PxDLS motif in human transcription factor SOX-6 that serves as the site for interaction with the transcriptional corepressor CtBP

Record No : 39

Instance ID10305
Regular Expression[^P]x[KR]xTQT
Motif InstanceYTKQTQT
Bait Uniprot AccessionQ24246
Bait Uniprot IdentifierDYIN_DROME
Bait Gene Namesw
Sequence Position128-134
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; NMR
Interaction ID20305
Interacting DomainDynein light chain type 1
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17570393
CommentsKxTQT-motif in Drosophila Cytoplasmic dynein 1 intermediate chain/ Protein short wing (sw) that binds to Drosophila LC8 (ctp)

Record No : 40

Instance ID10307
Regular Expression[^P]x[KR]xTQT
Motif InstanceSAKATQT
Bait Uniprot AccessionP40688
Bait Uniprot IdentifierSWA_DROME
Bait Gene Nameswa
Sequence Position289-295
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; Y2H; Co-IP; Pull down; Western blot; X-ray crystallography; NMR
Interaction ID20307
Interacting DomainDynein light chain type 1
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11148209, 10783235, 17570393
CommentsKxTQT-motif in Drosophila Protein swallow (swa) that binds to Drosophila LC8 (ctp)

Record No : 41

Instance ID10320
Regular ExpressionxNPFx
Motif InstanceANPFP
Bait Uniprot AccessionQ62910
Bait Uniprot IdentifierSYNJ1_RAT
Bait Gene NameSynj1
Sequence Position1400-1404
Critical ResiduesP2; P3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Competition binding; Pull down; Far Western blotting
Interaction ID20320
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9535728, 9428629
CommentsEH domain-dependent interaction between rat Eps15 and the 170 kDa isoform of endocytic protein Synaptojanin 1 mediated by the NPF motif (1400-1404) in the COOH-terminal region of Synaptojanin 1

Record No : 42

Instance ID10322
Regular ExpressionxNPFx
Motif InstanceGNPFR
Bait Uniprot AccessionQ62910
Bait Uniprot IdentifierSYNJ1_RAT
Bait Gene NameSynj1
Sequence Position1420-1424
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Far Western blotting; Competition binding; NMR; Pull down
Interaction ID20322
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9535728, 9428629, 10757979
CommentsEH domain-dependent interaction between rat Eps15 and the 170 kDa isoform of endocytic protein Synaptojanin 1 mediated by the NPF motif (1420-1424) in the COOH-terminal region of Synaptojanin 1

Record No : 43

Instance ID10331
Regular ExpressionxNPFx
Motif InstanceRNPFT
Bait Uniprot AccessionQ62910
Bait Uniprot IdentifierSYNJ1_RAT
Bait Gene NameSynj1
Sequence Position1409-1413
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Competition binding; Pull down; Far Western blotting
Interaction ID20331
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9535728, 9428629
CommentsEH domain-dependent interaction between rat Eps15 and the 170 kDa isoform of endocytic protein Synaptojanin 1 mediated by the NPF motif (1409-1413) in the COOH-terminal region of Synaptojanin 1

Record No : 44

Instance ID10342
Regular ExpressionxNPFx
Motif InstanceSNPFA
Bait Uniprot AccessionP56603
Bait Uniprot IdentifierSCAM1_RAT
Bait Gene NameScamp1
Sequence Position6-10
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Y2H
Interaction ID20342
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10777571
CommentsN-terminal NPF motif (6-10) of rat Secretory carrier membrane protein 1 (Scamp1) that interact with EH domain of Intersectin-1

Record No : 45

Instance ID10346
Regular ExpressionxNPFx
Motif InstanceNNPFK
Bait Uniprot AccessionP56603
Bait Uniprot IdentifierSCAM1_RAT
Bait Gene NameScamp1
Sequence Position15-19
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Y2H
Interaction ID20346
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10777571
CommentsN-terminal NPF motif (15-19) of rat Secretory carrier membrane protein 1 (Scamp1) that interact with EH domain of Intersectin-1

Record No : 46

Instance ID10348
Regular ExpressionxNPFx
Motif InstanceYNPFS
Bait Uniprot AccessionP56603
Bait Uniprot IdentifierSCAM1_RAT
Bait Gene NameScamp1
Sequence Position37-41
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Y2H
Interaction ID20348
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10777571
CommentsN-terminal NPF motif (37-41) of rat Secretory carrier membrane protein 1 (Scamp1) that interact with EH domain of Intersectin-1

Record No : 47

Instance ID10351
Regular ExpressionxNPFx
Motif InstanceTNPFL
Bait Uniprot AccessionQ8WXE9
Bait Uniprot IdentifierSTON2_HUMAN
Bait Gene NameSTON2
Sequence Position312-316
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; NMR; Co-IP; Pull down; ITC; Y2H
Interaction ID20351
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11381094, 18200045, 14726597
CommentsNPF motif (312-316) of human Stonin-2 (STON2) that interacts with the endocytic machinery protein EPS15

Record No : 48

Instance ID10352
Regular ExpressionxNPFx
Motif InstanceINPFS
Bait Uniprot AccessionQ8WXE9
Bait Uniprot IdentifierSTON2_HUMAN
Bait Gene NameSTON2
Sequence Position328-332
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; NMR; Co-IP; Pull down; ITC; Y2H
Interaction ID20352
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14726597, 18200045, 11381094
CommentsNPF motif (328-332) of human Stonin-2 (STON2) that interacts with the endocytic machinery protein EPS15

Record No : 49

Instance ID10371
Regular ExpressionxNPFx
Motif InstanceYNPFD
Bait Uniprot AccessionQ9Z2P6
Bait Uniprot IdentifierSNP29_RAT
Bait Gene NameSnap29
Sequence Position8-12
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down(His tag); Pull down(GST tag); Co-IP
Interaction ID20371
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15371016
CommentsEH domain-containing protein 1 associates with rat Synaptosomal-associated protein 29 (Snap29) via EH domain/NPF interactions through the NPF motif of Snap29

Record No : 50

Instance ID10394
Regular ExpressionxNPFx
Motif InstanceANPFL
Bait Uniprot AccessionQ24212
Bait Uniprot IdentifierSTNB_DROME
Bait Gene NamestnB
Sequence Position2-6
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Far Western blotting
Interaction ID20394
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15631619
CommentsThe NPF motif (2-6) in Drosophila stoned-B protein (stnB) that has been found to be high-affinity binding motif for the EH domain of DAP-160 (intersectin)

Record No : 51

Instance ID10395
Regular ExpressionxNPFx
Motif InstanceANPFL
Bait Uniprot AccessionQ24212
Bait Uniprot IdentifierSTNB_DROME
Bait Gene NamestnB
Sequence Position18-22
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Far Western blotting
Interaction ID20395
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15631619
CommentsThe NPF motif (18-22) in Drosophila stoned-B protein (stnB) that has been found to be high-affinity binding motif for the EH domain of DAP-160 (intersectin)

Record No : 52

Instance ID10396
Regular ExpressionxNPFx
Motif InstanceDNPFM
Bait Uniprot AccessionQ24212
Bait Uniprot IdentifierSTNB_DROME
Bait Gene NamestnB
Sequence Position32-36
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Far Western blotting
Interaction ID20396
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15631619
CommentsThe NPF motif (32-36) in Drosophila stoned-B protein (stnB) that has been found to be high-affinity binding motif for the EH domain of DAP-160 (intersectin)

Record No : 53

Instance ID10397
Regular ExpressionxNPFx
Motif InstanceSNPFA
Bait Uniprot AccessionQ24212
Bait Uniprot IdentifierSTNB_DROME
Bait Gene NamestnB
Sequence Position42-46
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Far Western blotting
Interaction ID20397
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15631619
CommentsThe NPF motif (42-46) in Drosophila stoned-B protein (stnB) that has been found to be high-affinity binding motif for the EH domain of DAP-160 (intersectin)

Record No : 54

Instance ID10398
Regular ExpressionxNPFx
Motif InstanceDNPFA
Bait Uniprot AccessionQ24212
Bait Uniprot IdentifierSTNB_DROME
Bait Gene NamestnB
Sequence Position209-213
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Far Western blotting
Interaction ID20398
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15631619
CommentsThe NPF motif (209-213) in Drosophila stoned-B protein (stnB) that has been found to be high-affinity binding motif for the EH domain of DAP-160 (intersectin)

Record No : 55

Instance ID10399
Regular ExpressionxNPFx
Motif InstanceANPFA
Bait Uniprot AccessionQ24212
Bait Uniprot IdentifierSTNB_DROME
Bait Gene NamestnB
Sequence Position492-496
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Far Western blotting
Interaction ID20399
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15631619
CommentsThe NPF motif (492-496) in Drosophila stoned-B protein (stnB) that has been found to be high-affinity binding motif for the EH domain of DAP-160 (intersectin)

Record No : 56

Instance ID10400
Regular ExpressionxNPFx
Motif InstanceVNPFE
Bait Uniprot AccessionQ24212
Bait Uniprot IdentifierSTNB_DROME
Bait Gene NamestnB
Sequence Position672-676
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Far Western blotting
Interaction ID20400
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15631619
CommentsThe NPF motif (672-676) in Drosophila stoned-B protein (stnB) that has been found to be high-affinity binding motif for the EH domain of DAP-160 (intersectin)

Record No : 57

Instance ID10449
Regular ExpressionPPxxF
Motif InstancePPEEF
Bait Uniprot AccessionQ9JLU4
Bait Uniprot IdentifierSHAN3_RAT
Bait Gene NameShank3
Sequence Position1385-1389
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Western blot; Pull down; Co-IP
Interaction ID20449
Interacting DomainWH1 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10433269
CommentsProline-rich motif (1385-1389) in rat Shank3 that is recognized by Class II EVH1 domain of Homer1

Record No : 58

Instance ID10450
Regular ExpressionPPxxF
Motif InstancePPPTF
Bait Uniprot AccessionQ9JLU4
Bait Uniprot IdentifierSHAN3_RAT
Bait Gene NameShank3
Sequence Position908-912
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Western blot; Pull down; Co-IP
Interaction ID20450
Interacting DomainWH1 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10433269
CommentsProline-rich motif (908-912) in rat Shank3 that is recognized by Class II EVH1 domain of Homer1

Record No : 59

Instance ID10471
Regular ExpressionP[MVLIRWY]V[MVLIAS][LM]
Motif InstancePVVMM
Bait Uniprot AccessionP20193
Bait Uniprot IdentifierSUV37_DROME
Bait Gene NameSu(var)3-7
Sequence Position394-398
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H; Classical fluorescence spectroscopy
Interaction ID20471
Interacting DomainChromo shadow domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12163401
CommentsThe PxVxL HP1-binding motif found in the Drosophila protein Suppressor of variegation 3-7 [Su(var)3-7] that interacts with a chomoshadow domain dimer of the heterochromatin protein 1 (HP1)

Record No : 60

Instance ID10474
Regular Expressionxxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx
Motif InstanceEVSAIVIQRAYRRYLLKQKV
Bait Uniprot AccessionP04775
Bait Uniprot IdentifierSCN2A_RAT
Bait Gene NameScn2a
Sequence Position1906-1925
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Fluorescence polarization spectroscopy; NMR
Interaction ID20474
Interacting DomainEF hand
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)21439835
CommentsThe Calmodulin binding IQ motif of the rat Na(V)1.2 voltage-dependent sodium channel (Scn2a) that binds to the apo C-domain of Paramecium Calmodulin (CaM)

Record No : 61

Instance ID10494
Regular Expressionxxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx
Motif InstanceEVSAVVLQRAYRGHLARRGF
Bait Uniprot AccessionQ9WTU3
Bait Uniprot IdentifierSCN8A_MOUSE
Bait Gene NameScn8a
Sequence Position1894-1913
Critical ResiduesP7; P8
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID20494
Interacting DomainEF hand
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12967988
CommentsBovine Calmodulin binds to the C terminus of mouse Voltage-gated sodium channel subunit alpha Nav1.6

Record No : 62

Instance ID10495
Regular Expressionxxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx
Motif InstanceEVCAIKIQRAYRRHLLQRSV
Bait Uniprot AccessionP15390
Bait Uniprot IdentifierSCN4A_RAT
Bait Gene NameScn4a
Sequence Position1721-1740
Critical ResiduesP7; P8
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Mutation analysis; Co-IP; Pull down(GST tag)
Interaction ID20495
Interacting DomainEF hand
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12967988
CommentsBovine Calmodulin binds to the C terminus of rat Voltage-gated sodium channel subunit alpha Nav1.4

Record No : 63

Instance ID10496
Regular Expressionxxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx
Motif InstanceEVSAMVIQRAFRRHLLQRSL
Bait Uniprot AccessionQ14524
Bait Uniprot IdentifierSCN5A_HUMAN
Bait Gene NameSCN5A
Sequence Position1902-1921
Critical ResiduesP7; P8; P9; P11; P12
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Fluorescence technology; Co-IP; Mutation analysis; NMR; Alanine scanning
Interaction ID20496
Interacting DomainEF hand
Disease Association(s)Brugada syndrome; Long QT syndrome
Inhibitor(s)Unknown
Reference(s)16505387, 21167176
CommentsThe ubiquitous calcium sensor protein calmodulin (CaM) binds to the human voltage-gated sodium channel NaV1.5 IQ motif

Record No : 64

Instance ID10508
Regular Expressionxxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx
Motif InstanceCVILPEIQKPERKIQFKEK
Bait Uniprot AccessionP38377
Bait Uniprot IdentifierS61A1_CANFA
Bait Gene NameSEC61A1
Sequence Position13-31
Critical ResiduesP12
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Fluorescence correlation spectroscopy; Peptideā€spot binding assay; Alanine scanning
Interaction ID20508
Interacting DomainEF hand
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)21102557
CommentsThe Calmodulin binding IQ motif in the cytosolic N-terminus of Protein transport protein Sec61 alpha-1 of Canis lupus familiaris that bound CaM but not Ca2+-free apocalmodulin with nanomolar affinity and sequence specificity

Record No : 65

Instance ID10509
Regular Expressionxxx[SACLIVTM]xx[ILVMFCT]Qx{3,3}[RK]x{4,5}[RKQ]xx
Motif InstanceEVSAVIIQRAYRRHLLKRTV
Bait Uniprot AccessionP04774
Bait Uniprot IdentifierSCN1A_RAT
Bait Gene NameScn1a
Sequence Position1916-1935
Critical ResiduesP7; P8
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Pull down; Co-IP; Mutation analysis
Interaction ID20509
Interacting DomainEF hand
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)21726526
CommentsThe ubiquitous calcium sensor calmodulin (CaM) binds to the IQ Motif of rat brain Voltage-gated sodium channel subunit alpha Nav1.1

Record No : 66

Instance ID10521
Regular Expression[KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF]
Motif InstanceRRNLKGLNLNL
Bait Uniprot AccessionP06784
Bait Uniprot IdentifierSTE7_YEAST
Bait Gene NameSTE7
Sequence Position9-19
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; Pull down; Fluorescence polarization spectroscopy
Interaction ID20521
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16364919
CommentsSaccharomyces cerevisiae MAPK kinase Ste7 docking motif 1 (9-19) that selectively binds the yeast Mitogen-activated protein kinase FUS3

Record No : 67

Instance ID10530
Regular Expression[KR]{0,2}[KR]x{0,2}[KR]x{2,4}[ILVM]x[ILVF]
Motif InstanceRRGIKKKLTL
Bait Uniprot AccessionP06784
Bait Uniprot IdentifierSTE7_YEAST
Bait Gene NameSTE7
Sequence Position62-71
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Competition Fluorescence Polarization Binding Assay
Interaction ID20530
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16364919
CommentsSaccharomyces cerevisiae MAPK kinase Ste7 docking motif 2 (62-71) that selectively binds the yeast Mitogen-activated protein kinase FUS3

Record No : 68

Instance ID10536
Regular ExpressionFxFP
Motif InstanceFPFP
Bait Uniprot AccessionQ9R1Z8
Bait Uniprot IdentifierVINEX_MOUSE
Bait Gene NameSorbs3
Sequence Position630-633
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20536
Interacting DomainProtein kinase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15184391
CommentsThe FXFP motif in mouse Vinexin (Sorbs3) that mediates binding to mouse MAP kinase 1 (or ERK-2)

Record No : 69

Instance ID10649
Regular Expressionxxx[ST]x[ACVILF]$
Motif InstanceLMETDV
Bait Uniprot AccessionQ9Q8T6
Bait Uniprot IdentifierQ9Q8T6_RFVKA
Bait Gene Names147R
Sequence Position282-287
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Display technology
Interaction ID20649
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18828675
CommentsC-terminal class 1 PDZ-binding motif in the Gp147R protein of Rabbit fibroma virus that binds to the human Scribble (SCRIB) PDZ domain

Record No : 70

Instance ID10661
Regular Expressionxxx[ST]x[ACVILF]$
Motif InstanceVQQTRV
Bait Uniprot AccessionQ9QUH6
Bait Uniprot IdentifierSYGP1_RAT
Bait Gene NameSyngap1
Sequence Position1303-1308
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Pull down; Co-IP; Competition binding; Y2H
Interaction ID20661
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9581761
CommentsC-terminal class 1 PDZ-binding motif in rat Ras-GTPase activating protein, Syngap1 that binds to the PDZ domain of rat Dlg4 or Psd95

Record No : 71

Instance ID10662
Regular Expressionxxx[ST]x[ACVILF]$
Motif InstanceVQQTRV
Bait Uniprot AccessionQ9QUH6
Bait Uniprot IdentifierSYGP1_RAT
Bait Gene NameSyngap1
Sequence Position1303-1308
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Pull down; Co-IP; Competition binding; Y2H
Interaction ID20662
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9581761
CommentsC-terminal class 1 PDZ-binding motif in rat Ras-GTPase activating protein, Syngap1 that binds to the PDZ domain of rat Dlg3 or SAP-102

Record No : 72

Instance ID10670
Regular Expressionxxx[ST]x[ACVILF]$
Motif InstanceASGSSV
Bait Uniprot AccessionO55207
Bait Uniprot IdentifierSYNJ2_RAT
Bait Gene NameSynj2
Sequence Position1288-1293
Critical ResiduesP4; P6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Peptide binding to perpetrator
Interaction ID20670
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10357812
CommentsClass 1 PDZ domain-binding motif in Isoform 7.5kb of mouse Synaptojanin-2 (Synj2) that binds to the PDZ domain of mouse Synaptojanin-2-binding protein (Synj2bp)/ Mitochondrial outer membrane protein 25 (Omp25)

Record No : 73

Instance ID10680
Regular Expressionxxx[VLIFY]x[ACVILF]$
Motif InstanceTNEFYA
Bait Uniprot AccessionP31431
Bait Uniprot IdentifierSDC4_HUMAN
Bait Gene NameSDC4
Sequence Position193-198
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)ITC; X-ray crystallography
Interaction ID20680
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12679023, 16533050, 12842047
CommentsThe C-terminal class 2 PDZ-binding motif of human Syndecan-4 (SDC4) that binds to the PDZ domain of human Syntenin-1 (SDCBP)

Record No : 74

Instance ID10683
Regular Expressionxxx[VLIFY]x[ACVILF]$
Motif InstanceQEEFYA
Bait Uniprot AccessionP18827
Bait Uniprot IdentifierSDC1_HUMAN
Bait Gene NameSDC1
Sequence Position305-310
Critical ResiduesP5
Motif PTM(s)Phosphorylation at Tyr-P5
Secondary StructureDisordered
Experimental Method(s)Pull down; Mutation analysis
Interaction ID20683
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19228696
CommentsThe C-terminal class 2 PDZ-binding motif of human Syndecan-1 (SDC1) that binds to the PDZ domain of human Syntenin-1 (SDCBP) on dephosphorylation of Tyr-309

Record No : 75

Instance ID10698
Regular Expressionxx[RK]x{0,1}[VIL][^P][FW]x
Motif InstanceDQKVDFD
Bait Uniprot AccessionP34758
Bait Uniprot IdentifierSCD5_YEAST
Bait Gene NameSCD5
Sequence Position238-244
Critical ResiduesP4; P5; P6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H; Western blot
Interaction ID20698
Interacting DomainCalcineurin-like phosphoesterase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12356757
CommentsScd5p, a protein important for endocytosis and actin organization in yeast, interacts with Glc7p, a yeast Ser/Thr-specific protein phosphatase-1 (PP1), through the potential PP1-binding site at amino acids 238-244 of SCD5

Record No : 76

Instance ID10699
Regular Expressionxx[RK]x{0,1}[VIL][^P][FW]x
Motif InstanceSKKVRFS
Bait Uniprot AccessionP34758
Bait Uniprot IdentifierSCD5_YEAST
Bait Gene NameSCD5
Sequence Position271-277
Critical ResiduesP4; P5; P6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H; Western blot
Interaction ID20699
Interacting DomainCalcineurin-like phosphoesterase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12356757
CommentsScd5p, a protein important for endocytosis and actin organization in yeast, interacts with Glc7p, a yeast Ser/Thr-specific protein phosphatase-1 (PP1), through the potential PP1-binding site at amino acids 271-277 of SCD5

Record No : 77

Instance ID10713
Regular ExpressionxP[^P]I[^P][IV][^P]
Motif InstanceVPNIYIQ
Bait Uniprot AccessionP40485
Bait Uniprot IdentifierSLM1_YEAST
Bait Gene NameSLM1
Sequence Position672-678
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H; Phosphatase assay
Interaction ID20713
Interacting DomainCalcineurin-like phosphoesterase domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16738335
CommentsIn Saccharomyces cerevisiae, Ca2+/calmodulin-dependent phosphatase calcineurin dephosphorylates TORC2 effector protein SLM1 and interacts with it through the calcineurin docking motif in SLM1

Record No : 78

Instance ID10728
Regular ExpressionxP[TS]APx
Motif InstancePPSAPS
Bait Uniprot AccessionO14828
Bait Uniprot IdentifierSCAM3_HUMAN
Bait Gene NameSCAMP3
Sequence Position63-68
Critical ResiduesP5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)SPR; Mutation analysis
Interaction ID20728
Interacting DomainUEV domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19158374
CommentsHuman Secretory carrier-associated membrane protein SCAMP3 localizes in part to early endosomes and negatively regulates EGFR degradation through processes that involve its ubiquitylation and interactions with the UEV domain of human ESCRT-I complex subunit TSG101

Record No : 79

Instance ID10731
Regular ExpressionxP[TS]APx
Motif InstanceAPSAPM
Bait Uniprot AccessionP08363
Bait Uniprot IdentifierVP8_BTV10
Bait Gene NameS10
Sequence Position40-45
Critical ResiduesP2; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Confocal microscopy; Pull down; Mutation analysis
Interaction ID20731
Interacting DomainUEV domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16352570
CommentsThe UEV Domain binding P[TS]AP motif in Non-structural protein NS3 of Bluetongue virus 10 that mediates binding to the UEV domain of human ESCRT-I complex subunit TSG101

Record No : 80

Instance ID10753
Regular Expression(x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x)
Motif InstanceVFTNAAFD
Bait Uniprot AccessionP16109
Bait Uniprot IdentifierLYAM3_HUMAN
Bait Gene NameSELP
Sequence Position820-827
Critical ResiduesP2; P7
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Site-directed mutagenesis; Y2H; SPR
Interaction ID20753
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19138666
CommentsThe N-terminal phosphotyrosine-binding (PTB) domain of Human Numb3 (NUMB) binds to the cytosolic tail of the leukocyte adhesion receptor P-selectin (SELP)

Record No : 81

Instance ID10756
Regular Expression(x[^P]xNPx[FY]x)|(x[ILVMFY]xNxx[FY]x)
Motif InstanceSVPNPVFG
Bait Uniprot AccessionQ9NY15
Bait Uniprot IdentifierSTAB1_HUMAN
Bait Gene NameSTAB1
Sequence Position2536-2543
Critical ResiduesP4; P7
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Competition binding; Pull down; Alanine scanning
Interaction ID20756
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)20599701
CommentsThe PTB domain of human adapter protein GULP is able to specifically interact with the NPxF/Y motif of human phagocytic receptor Stabilin-1 (STAB1) cytoplasmic region thus functioning as an adaptor protein for Stabilin-1-mediated phagocytosis

Record No : 82

Instance ID10790
Regular Expression[LI]xCx[DE]
Motif InstanceLTCEE
Bait Uniprot AccessionP51531
Bait Uniprot IdentifierSMCA2_HUMAN
Bait Gene NameSMARCA2
Sequence Position1294-1298
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP
Interaction ID20790
Interacting DomainB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9326598
CommentsThe Rb-binding LxCxE motif in the Human ATP-dependent helicase SMARCA2 that mediates binding to the human retinoblastoma protein (RB) to repress S-phase-inducing transcription factor E2F1, thereby preventing cells from entering S phase

Record No : 83

Instance ID10816
Regular ExpressionRGD
Motif InstanceRGD
Bait Uniprot AccessionP10451
Bait Uniprot IdentifierOSTP_HUMAN
Bait Gene NameSPP1
Sequence Position159-161
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID20816
Interacting DomainN-terminal Integrin beta subunit
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)8910476
CommentsHuman Osteopontin N-terminal domain contains the RGD motif that mediates binding to Human Integrin beta-1 (ITGB1)

Record No : 84

Instance ID10821
Regular Expression[LIVMP]x{0,2}(T)Pxx([ST])
Motif InstanceLTPPPS
Bait Uniprot AccessionP36956
Bait Uniprot IdentifierSRBP1_HUMAN
Bait Gene NameSREBF1
Sequence Position425-430
Critical ResiduesP2; P6
Motif PTM(s)Phosphorylation at Thr-P2 & Ser-P6
Secondary StructureUnknown
Experimental Method(s)Protein kinase assay; ChIP; Mutation analysis; Co-IP
Interaction ID20821
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16825193, 16054087
CommentsThe TPxxS phospho-dependent degron in Human Sterol regulatory element-binding protein 1 (SREBF1) that serves as a recognition motif for the SCF(FBW7) ubiquitin ligase and enhances its ubiquitination and degradation in a manner dependent on the phosphorylation of T426 and S430

Record No : 85

Instance ID10851
Regular Expression(Y)xNx
Motif InstanceYVNV
Bait Uniprot AccessionP29353
Bait Uniprot IdentifierSHC1_HUMAN
Bait Gene NameSHC1
Sequence Position427-430
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureBeta turn
Experimental Method(s)NMR
Interaction ID20851
Interacting DomainSH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10356320, 9710204
CommentsTyrosine-phosphorylated (Y427) Human SHC-transforming protein 1 (SHC1) binds specifically to the SH2-domain of the human Adapter protein GRB2

Record No : 86

Instance ID10858
Regular Expression(Y)[QDEVAIL][DENPYHI][IPVGAHS]
Motif InstanceYQPG
Bait Uniprot AccessionP12931
Bait Uniprot IdentifierSRC_HUMAN
Bait Gene NameSRC
Sequence Position530-533
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography
Interaction ID20858
Interacting DomainSH2 domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)10360179
CommentsThe human Proto-oncogene tyrosine-protein kinase SRC is maintained in an assembled, inactive conformation by intramolecular interactions of the phosphorylated C-terminal tail (Tyr-527) with the SH2 domain locks the molecule in an inhibited conformation

Record No : 87

Instance ID10880
Regular ExpressionPxxPx[KR]
Motif InstancePPVPPR
Bait Uniprot AccessionQ07889
Bait Uniprot IdentifierSOS1_HUMAN
Bait Gene NameSOS1
Sequence Position1151-1156
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)ITC; Pull down; Co-IP; Competition binding
Interaction ID20880
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8479541, 23334917
CommentsThe SH3 domains of Adapter protein GRB2 bind to the carboxy-terminal part of hSos1, the human homologue of the Drosophila guanine-nucleotide-releasing factor for Ras, and the GRB2/SOS1 complex couples activated EGF receptor to Ras signalling

Record No : 88

Instance ID10881
Regular ExpressionPxxPx[KR]
Motif InstancePVPPRR
Bait Uniprot AccessionQ07889
Bait Uniprot IdentifierSOS1_HUMAN
Bait Gene NameSOS1
Sequence Position1152-1157
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)Co-IP; Pull down
Interaction ID20881
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8479541
CommentsThe SH3 domains of Adapter protein GRB2 bind to the carboxy-terminal part of hSos1, the human homologue of the Drosophila guanine-nucleotide-releasing factor for Ras, and the GRB2/SOS1 complex couples activated EGF receptor to Ras signalling

Record No : 89

Instance ID10901
Regular Expressionxxx[PV]xxP
Motif InstanceVPPPVPP
Bait Uniprot AccessionQ62245
Bait Uniprot IdentifierSOS1_MOUSE
Bait Gene NameSos1
Sequence Position1135-1141
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)NMR
Interaction ID20901
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9135122
CommentsInteraction between the N-terminal SH3 domain of Mouse growth factor receptor-bound protein 2 (Grb2) with the mouse Son-of-Sevenless (Sos) protein is mediated by a proline-rich peptide of the mouse Sos1 sequence

Record No : 90

Instance ID10924
Regular ExpressionxPxAxVxP[^P]
Motif InstanceRPTAAVTPI
Bait Uniprot AccessionQ7Z6J0
Bait Uniprot IdentifierSH3R1_HUMAN
Bait Gene NameSH3RF1
Sequence Position600-608
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H; Co-IP
Interaction ID20924
Interacting DomainTRAF-like domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16230351
CommentsHuman E3 ubiquitin-protein ligase SIAH1 is a binding partner for E3 ubiquitin-protein ligase SH3RF1/ POSH (Plenty of SH3s), a scaffold component of the apoptotic JNK pathway, and thus contributes to promotion of apoptotic death by activating the JNK pathway

Record No : 91

Instance ID10932
Regular ExpressionRF[^P][IV]x
Motif InstanceRFQVH
Bait Uniprot AccessionP55014
Bait Uniprot IdentifierS12A1_MOUSE
Bait Gene NameSlc12a1
Sequence Position16-20
Critical ResiduesP1; P2; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H; Alanine scanning
Interaction ID20932
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12386165
CommentsMouse Kidney-specific Na-K-Cl symporter Slc12a1/Nkcc2 interacts with the conserved C-terminal (CCT) domain of mouse stress-related kinase Stk39/Spak through its RFxV docking motif

Record No : 92

Instance ID10944
Regular ExpressionRF[^P][IV]x
Motif InstanceRFRVN
Bait Uniprot AccessionP55012
Bait Uniprot IdentifierS12A2_MOUSE
Bait Gene NameSlc12a2
Sequence Position133-137
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H; Mutation analysis
Interaction ID20944
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14563843, 17595523
CommentsMouse Basolateral Na-K-Cl symporter Slc12a2/Nkcc1 interacts with the conserved C-terminal (CCT) domain of mouse Oxidative stress-responsive 1 protein (Oxsr1) through its RFxV docking motif (133-137)

Record No : 93

Instance ID10945
Regular ExpressionRF[^P][IV]x
Motif InstanceRFRVN
Bait Uniprot AccessionP55012
Bait Uniprot IdentifierS12A2_MOUSE
Bait Gene NameSlc12a2
Sequence Position133-137
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H; Mutation analysis
Interaction ID20945
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14563843, 17595523
CommentsMouse Basolateral Na-K-Cl symporter Slc12a2/Nkcc1 interacts with the conserved C-terminal (CCT) domain of mouse stress-related kinase Stk39/Spak through its RFxV docking motif (133-137)

Record No : 94

Instance ID10946
Regular ExpressionRF[^P][IV]x
Motif InstanceRFMVT
Bait Uniprot AccessionQ924N4
Bait Uniprot IdentifierS12A6_MOUSE
Bait Gene NameSlc12a6
Sequence Position14-18
Critical ResiduesP1; P2; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Y2H; Mutation analysis
Interaction ID20946
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12386165
CommentsMouse Electroneutral K-Cl cotransporter 3 (Kcc3/Slc12a6) interacts with the conserved C-terminal (CCT) domain of mouse stress-related kinase Stk39/Spak through its RFxV docking motif

Record No : 95

Instance ID10947
Regular ExpressionRF[^P][IV]x
Motif InstanceRFTIS
Bait Uniprot AccessionP55017
Bait Uniprot IdentifierS12A3_HUMAN
Bait Gene NameSLC12A3
Sequence Position19-23
Critical ResiduesP1
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20947
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18270262
CommentsHuman Na-Cl cotransporter SLC12A3/NCC interacts with the conserved C-terminal (CCT) domain of human Oxidative stress-responsive 1 protein (OXSR1) through its RFXI motif

Record No : 96

Instance ID10948
Regular ExpressionRF[^P][IV]x
Motif InstanceRFTIS
Bait Uniprot AccessionP55017
Bait Uniprot IdentifierS12A3_HUMAN
Bait Gene NameSLC12A3
Sequence Position19-23
Critical ResiduesP1
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20948
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18270262
CommentsHuman Na-Cl cotransporter SLC12A3/NCC interacts with the conserved C-terminal (CCT) domain of human STE20-related kinase STK39/SPAK through its RFXI motif

Record No : 97

Instance ID10949
Regular ExpressionRF[^P][IV]x
Motif InstanceRFQVD
Bait Uniprot AccessionP55012
Bait Uniprot IdentifierS12A2_MOUSE
Bait Gene NameSlc12a2
Sequence Position77-81
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H; Mutation analysis
Interaction ID20949
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14563843, 17595523
CommentsMouse Basolateral Na-K-Cl symporter Slc12a2/Nkcc1 interacts with the conserved C-terminal (CCT) domain of mouse Oxidative stress-responsive 1 protein (Oxsr1) through its RFxV docking motif (77-81)

Record No : 98

Instance ID10950
Regular ExpressionRF[^P][IV]x
Motif InstanceRFQVD
Bait Uniprot AccessionP55012
Bait Uniprot IdentifierS12A2_MOUSE
Bait Gene NameSlc12a2
Sequence Position77-81
Critical ResiduesP2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H; Mutation analysis
Interaction ID20950
Interacting DomainConserved C-Terminal (CCT) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14563843, 17595523
CommentsMouse Basolateral Na-K-Cl symporter Slc12a2/Nkcc1 interacts with the conserved C-terminal (CCT) domain of mouse stress-related kinase Stk39/Spak through its RFxV docking motif (77-81)

Record No : 99

Instance ID10976
Regular Expression[ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10}
Motif InstanceLIDLT
Bait Uniprot AccessionP39955
Bait Uniprot IdentifierSAP1_YEAST
Bait Gene NameSAP1
Sequence Position235-239
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureExtended conformation
Experimental Method(s)Y2H
Interaction ID20976
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15590687
CommentsThe potential SUMO-binding motif in Sap1 protein of Saccharomyces cerevisiae that mediates interactions with Ubiquitin-like protein Smt3 in Saccharomyces cerevisiae

Record No : 100

Instance ID10977
Regular Expression[ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10}
Motif InstanceIIISDSDDDDDE
Bait Uniprot AccessionQ7Z333
Bait Uniprot IdentifierSETX_HUMAN
Bait Gene NameSETX
Sequence Position1014-1025
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureExtended conformation
Experimental Method(s)Y2H; Mutation analysis
Interaction ID20977
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16524884
CommentsThe SUMO-interacting motif (SIM) of human Senataxin (SETX), a newly identified helicase mutated in patients suffering from ataxia-ocular apraxia 2, that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1)

Record No : 101

Instance ID10978
Regular Expression[ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10}
Motif InstanceIIVISSEDSE
Bait Uniprot AccessionP23497
Bait Uniprot IdentifierSP100_HUMAN
Bait Gene NameSP100
Sequence Position323-332
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureExtended conformation
Experimental Method(s)Mutation analysis; Y2H; Pull down(GST tag)
Interaction ID20978
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16524884
CommentsThe SUMO-interacting motif (SIM) of human Nuclear autoantigen SP100 that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1)

Record No : 102

Instance ID10991
Regular Expression([KR][^ED]{0,5}[ST]xIP[^ED]{5,5})|([^ED]{5,5}[ST]xIP[^ED]{0,5}[KR])
Motif InstanceQASRNTRIPHLAGKK
Bait Uniprot AccessionQ13586
Bait Uniprot IdentifierSTIM1_HUMAN
Bait Gene NameSTIM1
Sequence Position637-651
Critical ResiduesP5; P6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Classical fluorescence spectroscopy; Mutation analysis
Interaction ID20991
Interacting DomainEBH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19632184
CommentsThe C-terminal EBH domain of human End-binding protein 1 (EB1) or MAPRE1 binds to the SxIP motif of human Stromal interaction molecule 1 (STIM1)

Record No : 103

Instance ID10994
Regular ExpressionxRxx[PGAV][DEIP]Gx
Motif InstanceQRSPPDGQ
Bait Uniprot AccessionP78314
Bait Uniprot Identifier3BP2_HUMAN
Bait Gene NameSH3BP2
Sequence Position414-421
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Fluorescence polarization spectroscopy; Alanine scanning; Pull down; Co-IP
Interaction ID20994
Interacting DomainAnkyrin repeat domain
Disease Association(s)Cherubism
Inhibitor(s)Unknown
Reference(s)22153077
CommentsThe N-terminal region of ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif in human SH3 domain-binding protein 2 (SH3BP2)

Record No : 104

Instance ID11010
Regular ExpressionxRxx[PGAV][DEIP]Gx
Motif InstanceSRSAGDGT
Bait Uniprot AccessionO43815
Bait Uniprot IdentifierSTRN_HUMAN
Bait Gene NameSTRN
Sequence Position301-308
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Fluorescence polarization spectroscopy; Mutation analysis; Co-IP
Interaction ID21010
Interacting DomainAnkyrin repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)22153077
CommentsThe N-terminal region of ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif in human Striatin (STRN)

Record No : 105

Instance ID11022
Regular Expression[PSAT]x[QE]E
Motif InstancePVQE
Bait Uniprot AccessionP18347
Bait Uniprot IdentifierTSTP_SHV21
Bait Gene NameSTP
Sequence Position60-63
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Western blot; Co-IP; Mutation analysis
Interaction ID21022
Interacting DomainMATH domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)10196286
CommentsThe Transforming STP oncoprotein of the herpesvirus saimiri (HVS) are found to be stably associated with human TNF receptor-associated factor 2 (TRAF2) through its TRAF2-binding consensus motif

Record No : 106

Instance ID11036
Regular Expression[KR]{1,4}[KR]x[KR]Wx
Motif InstanceKRKSRWD
Bait Uniprot AccessionO75533
Bait Uniprot IdentifierSF3B1_HUMAN
Bait Gene NameSF3B1
Sequence Position333-339
Critical ResiduesP6
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography; NMR; Pull down; Mutation analysis; ITC
Interaction ID21036
Interacting DomainUHM domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17589525, 16376933
CommentsHuman Splicing factor 45 (SPF45)/ RNA-binding motif protein 17 (RBM17) binds to the UHM-ligand motif (ULM) present in human Splicing factor 3B subunit 1 (SF3B1) for regulating the alternative splicing of apoptosis regulatory gene FAS

Record No : 107

Instance ID11037
Regular Expression[KR]{1,4}[KR]x[KR]Wx
Motif InstanceKKRKRSRWN
Bait Uniprot AccessionQ15637
Bait Uniprot IdentifierSF01_HUMAN
Bait Gene NameSF1
Sequence Position15-23
Critical ResiduesP7; P8
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; NMR
Interaction ID21037
Interacting DomainUHM domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12718882
CommentsThe C-terminal RRM (RRM3) of human Splicing factor U2AF65/U2AF2 binds to the N-terminal UHM ligand motif (ULM) of human Splicing factor 1 (SF1)

Record No : 108

Instance ID11051
Regular ExpressionPPxY
Motif InstancePPRY
Bait Uniprot AccessionP08363
Bait Uniprot IdentifierVP8_BTV10
Bait Gene NameS10
Sequence Position36-39
Critical ResiduesP1; P2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Western blot; Mutation analysis
Interaction ID21051
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16352570
CommentsNon-structural protein NS3 (S10) of Bluetongue virus (BTV) harbors a PPXY late-domain motif that allows NS3 to bind Human E3 ubiquitin-protein ligase NEDD4

Record No : 109

Instance ID11058
Regular ExpressionPPxY
Motif InstancePPAY
Bait Uniprot AccessionQ15797
Bait Uniprot IdentifierSMAD1_HUMAN
Bait Gene NameSMAD1
Sequence Position224-227
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)NMR
Interaction ID21058
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)21685363
CommentsThe PY motif of human SMAD1 that binds to the WW domain of human E3 ubiquitin-protein ligase SMURF1

Record No : 110

Instance ID11060
Regular ExpressionPPxY
Motif InstancePPKY
Bait Uniprot AccessionP51170
Bait Uniprot IdentifierSCNNG_HUMAN
Bait Gene NameSCNN1G
Sequence Position624-627
Critical ResiduesP4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP; RNA interference; Ubiquitinase assay; Mutation analysis; Western blot
Interaction ID21060
Interacting DomainWW domain
Disease Association(s)Liddle's Syndrome
Inhibitor(s)Unknown
Reference(s)17502380
CommentsThe PPXY motif of human Epithelial Na(+) channel subunit gamma (SCNN1G) that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4L/Nedd4-2

Record No : 111

Instance ID11061
Regular ExpressionPPxY
Motif InstancePPNY
Bait Uniprot AccessionP51168
Bait Uniprot IdentifierSCNNB_HUMAN
Bait Gene NameSCNN1B
Sequence Position617-620
Critical ResiduesP4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP; RNA interference; Ubiquitinase assay; Mutation analysis; Western blot
Interaction ID21061
Interacting DomainWW domain
Disease Association(s)Liddle's Syndrome
Inhibitor(s)Unknown
Reference(s)17502380
CommentsThe PPXY motif of human Epithelial Na(+) channel subunit beta (SCNN1B) that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4L/Nedd4-2

Record No : 112

Instance ID11062
Regular ExpressionPPxY
Motif InstancePPAY
Bait Uniprot AccessionP37088
Bait Uniprot IdentifierSCNNA_HUMAN
Bait Gene NameSCNN1A
Sequence Position641-644
Critical ResiduesP4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP; RNA interference; Ubiquitinase assay; Mutation analysis; Western blot
Interaction ID21062
Interacting DomainWW domain
Disease Association(s)Liddle's Syndrome
Inhibitor(s)Unknown
Reference(s)17502380
CommentsThe PPXY motif of human Epithelial Na(+) channel subunit alpha (SCNN1A) that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4L/Nedd4-2

Record No : 113

Instance ID11071
Regular Expressionxxx([ST])Px
Motif InstanceCVLSPV
Bait Uniprot AccessionQ9Y6H5
Bait Uniprot IdentifierSNCAP_HUMAN
Bait Gene NameSNCAIP
Sequence Position208-213
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Co-IP; Mutation analysis; Classical fluorescence spectroscopy; Phosphatase assay; Pull down
Interaction ID21071
Interacting DomainWW domain
Disease Association(s)Parkinson disease
Inhibitor(s)Unknown
Reference(s)16365047
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-211-Pro motif of human Synphilin-1 (SNCAIP), an alpha-synuclein partner, and enhances its interaction with alpha-synuclein, thus likely facilitating the formation of alpha-synuclein inclusions

Record No : 114

Instance ID11074
Regular Expressionxxx([ST])Px
Motif InstanceSDSSPS
Bait Uniprot AccessionP35210
Bait Uniprot IdentifierSPT23_YEAST
Bait Gene NameSPT23
Sequence Position651-656
Critical ResiduesP4; P5
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Phosphatase assay; Pull down; Alanine scanning
Interaction ID21074
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19597489
CommentsThe yeast peptidyl-prolyl cis/trans isomerase Pin1 (Ess1) is essential for viability because it controls the NF-kappaB-related Spt23 transcription factor involved in unsaturated fatty-acid synthesis via an interaction with phosphorylated Ser-654 of Spt23

Record No : 115

Instance ID11076
Regular Expressionxxx([ST])Px
Motif InstancePVKSPH
Bait Uniprot AccessionQ9Y6H5
Bait Uniprot IdentifierSNCAP_HUMAN
Bait Gene NameSNCAIP
Sequence Position212-217
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Co-IP; Mutation analysis; Classical fluorescence spectroscopy; Phosphatase assay; Pull down
Interaction ID21076
Interacting DomainWW domain
Disease Association(s)Parkinson disease
Inhibitor(s)Unknown
Reference(s)16365047
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-215-Pro motif of human Synphilin-1 (SNCAIP), an alpha-synuclein partner, and enhances its interaction with alpha-synuclein, thus likely facilitating the formation of alpha-synuclein inclusions

Record No : 116

Instance ID11087
Regular Expressionxxx([ST])Px
Motif InstanceDAGSPN
Bait Uniprot AccessionP84022
Bait Uniprot IdentifierSMAD3_HUMAN
Bait Gene NameSMAD3
Sequence Position201-206
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Co-IP; Pull down; Alanine scanning
Interaction ID21087
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)19122240
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-204-Pro motif of human SMAD3 thereby inducing its degradation

Record No : 117

Instance ID11088
Regular Expressionxxx([ST])Px
Motif InstanceTPSTPG
Bait Uniprot AccessionQ9BR01
Bait Uniprot IdentifierST4A1_HUMAN
Bait Gene NameSULT4A1
Sequence Position8-13
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Thr-P4
Secondary StructureUnknown
Experimental Method(s)Pull down; Y2H; Co-IP; Mutation analysis
Interaction ID21088
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19439498, 20920535
CommentsThe human cytosolic Aryl Sulfotransferase 4A1 interacts with the human Peptidyl-prolyl cis-trans isomerase PIN1 through its Thr-11-Pro motif

Record No : 118

Instance ID11105
Regular Expressionxxx([ST])Px
Motif InstanceIIFSPK
Bait Uniprot AccessionO64645
Bait Uniprot IdentifierSOC1_ARATH
Bait Gene NameSOC1
Sequence Position46-51
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Fluorescence technology; Alanine scanning; Phosphatase assay; NMR; Pull down(GST tag); BiFC assay
Interaction ID21105
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)20129060
CommentsArabidopsis Peptidyl-prolyl cis-trans isomerase Pin1/PIN1At interacts with the phosphorylated Ser-49-Pro motif of Arabidopsis MADS-box protein SOC1 and thereby regulates flowering time in Arabidopsis

Record No : 119

Instance ID11107
Regular Expressionxxx([ST])Px
Motif InstanceEESSPS
Bait Uniprot AccessionO64645
Bait Uniprot IdentifierSOC1_ARATH
Bait Gene NameSOC1
Sequence Position192-197
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Fluorescence technology; Alanine scanning; Phosphatase assay
Interaction ID21107
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)20129060
CommentsArabidopsis Peptidyl-prolyl cis-trans isomerase Pin1/PIN1At interacts with the phosphorylated Ser-195-Pro motif of Arabidopsis MADS-box protein SOC1 and thereby regulates flowering time in Arabidopsis

Record No : 120

Instance ID11114
Regular Expressionxxx([ST])Px
Motif InstanceIPETPP
Bait Uniprot AccessionP84022
Bait Uniprot IdentifierSMAD3_HUMAN
Bait Gene NameSMAD3
Sequence Position176-181
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Thr-P4
Secondary StructureUnknown
Experimental Method(s)NMR; Co-IP; Pull down; Alanine scanning
Interaction ID21114
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)21685363, 19122240
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Thr-179-Pro motif of human SMAD3 thereby inducing its degradation

Record No : 121

Instance ID11115
Regular Expressionxxx([ST])Px
Motif InstanceNPMSPA
Bait Uniprot AccessionP84022
Bait Uniprot IdentifierSMAD3_HUMAN
Bait Gene NameSMAD3
Sequence Position210-215
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Co-IP; Pull down; Alanine scanning
Interaction ID21115
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)19122240
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-213-Pro motif of human SMAD3 thereby inducing its degradation

Record No : 122

Instance ID11116
Regular Expressionxxx([ST])Px
Motif InstancePNLSPN
Bait Uniprot AccessionP84022
Bait Uniprot IdentifierSMAD3_HUMAN
Bait Gene NameSMAD3
Sequence Position205-210
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Co-IP; Pull down; Alanine scanning
Interaction ID21116
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)19122240
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-208-Pro motif of human SMAD3 thereby inducing its degradation

Record No : 123

Instance ID11127
Regular Expressionxxx([ST])Px
Motif InstanceEAETPS
Bait Uniprot AccessionQ9BR01
Bait Uniprot IdentifierST4A1_HUMAN
Bait Gene NameSULT4A1
Sequence Position5-10
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Thr-P4
Secondary StructureUnknown
Experimental Method(s)Pull down; Y2H; Co-IP; Mutation analysis
Interaction ID21127
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19439498, 20920535
CommentsThe human cytosolic Aryl Sulfotransferase 4A1 interacts with the human Peptidyl-prolyl cis-trans isomerase PIN1 through its Thr-8-Pro motif

Record No : 124

Instance ID11136
Regular Expressionxxx([ST])Px
Motif InstanceLPMSPR
Bait Uniprot AccessionP40763
Bait Uniprot IdentifierSTAT3_HUMAN
Bait Gene NameSTAT3
Sequence Position724-729
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Pull down; Co-IP; Alanine scanning
Interaction ID21136
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)17563747
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Ser-727-Pro motif of human Acute-phase response factor STAT3 upon cytokine/growth factor stimulation and promotes STAT3 transcriptional activity

Record No : 125

Instance ID11198
Regular ExpressionPPLP
Motif InstancePPLP
Bait Uniprot AccessionQ64213
Bait Uniprot IdentifierSF01_MOUSE
Bait Gene NameSf1
Sequence Position575-578
Critical ResiduesP1; P2; P3; P4
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Alanine scanning; Far Western blotting; SPR
Interaction ID21198
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9171351
CommentsThe PPLP motif in mouse Splicing factor 1 (Sf1) that is recognized by the group II WW domain of mouse Formin-binding protein 11 (Fbp11)

Record No : 126

Instance ID11267
Regular Expression[KR]xTQTx
Motif InstanceKATQTD
Bait Uniprot AccessionP40688
Bait Uniprot IdentifierSWA_DROME
Bait Gene Nameswa
Sequence Position291-296
Critical ResiduesP1; P3; P4
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography; NMR; Y2H; pull down(GST tag); protection from proteolytic digestion
Interaction ID21267
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15078108, 10783235, 17570393
CommentsAn interaction between Drosophila LC8 (or ctp), the highly conserved light-chain subunit of cytoplasmic dynein, and the Drosophila protein swallow (swa) promotes assembly of the coiled-coil domain of swallow protein

Record No : 127

Instance ID11268
Regular Expression[KR]xTQTx
Motif InstanceKQTQTT
Bait Uniprot AccessionQ24246
Bait Uniprot IdentifierDYIN_DROME
Bait Gene Namesw
Sequence Position130-135
Critical ResiduesP1; P3; P4
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography; NMR; pull down(GST tag); protection from proteolytic digestion; Far-UV CD spectropolarimetry; EMSA; Fluorescence Spectroscopy
Interaction ID21268
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17570393, 15581372
CommentsThe N-terminal domain of Drosophila Cytoplasmic dynein 1 intermediate chain (sw), is highly disordered, but upon binding to Drosophila cytoplasmic dynein light-chain subunit LC8 (or ctp), it undergoes a significant conformational change to a more ordered structure

Record No : 128

Instance ID11338
Regular Expression[DS]Kx[TVI]Q[TV][DE]
Motif InstanceERAIQTD
Bait Uniprot AccessionB5DF41
Bait Uniprot IdentifierSNPH_RAT
Bait Gene NameSnph
Sequence Position311-317
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Peptide binding assay
Interaction ID21338
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)21533121
CommentsThe LC8 dynein light chain binding motif in rat Syntaphilin (Snph) that interacts with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8)

Record No : 129

Instance ID11339
Regular Expression[DS]Kx[TVI]Q[TV][DE]
Motif InstanceERAIQTD
Bait Uniprot AccessionB5DF41
Bait Uniprot IdentifierSNPH_RAT
Bait Gene NameSnph
Sequence Position311-317
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Peptide binding assay
Interaction ID21339
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)21533121
CommentsThe LC8 dynein light chain binding motif in rat Syntaphilin (Snph) that interacts with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2)

Record No : 130

Instance ID11642
Regular ExpressionPPxY
Motif InstancePPTY
Bait Uniprot AccessionQ8N3V7
Bait Uniprot IdentifierSYNPO_HUMAN
Bait Gene NameSYNPO
Sequence Position562-565
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID21642
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12042308
CommentsPPxY motif (562-565) in synaptopodin that mediates its interaction with the second WW domain of MAGI-1

Record No : 131

Instance ID11643
Regular ExpressionPPxY
Motif InstancePPSY
Bait Uniprot AccessionQ8N3V7
Bait Uniprot IdentifierSYNPO_HUMAN
Bait Gene NameSYNPO
Sequence Position581-584
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID21643
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12042308
CommentsPPxY motif (581-584) in synaptopodin that mediates its interaction with the second WW domain of MAGI-1

Record No : 132

Instance ID11644
Regular ExpressionPPxY
Motif InstancePPTY
Bait Uniprot AccessionQ8N3V7
Bait Uniprot IdentifierSYNPO_HUMAN
Bait Gene NameSYNPO
Sequence Position562-565
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis
Interaction ID21644
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18596123
CommentsPPxY motif (562-565) in synaptopodin that mediates its interaction with both WW domains of KIBRA (WWC1)

Record No : 133

Instance ID11645
Regular ExpressionPPxY
Motif InstancePPSY
Bait Uniprot AccessionQ8N3V7
Bait Uniprot IdentifierSYNPO_HUMAN
Bait Gene NameSYNPO
Sequence Position581-584
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis
Interaction ID21645
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18596123
CommentsPPxY motif (581-584) in synaptopodin that mediates its interaction with both WW domains of KIBRA (WWC1)

Record No : 134

Instance ID11658
Regular Expression[YFG][YFHW][WFA]$
Motif InstanceFYA
Bait Uniprot AccessionP18827
Bait Uniprot IdentifierSDC1_HUMAN
Bait Gene NameSDC1
Sequence Position308-310
Critical ResiduesP2; P3
Motif PTM(s)Phosphorylation at Tyr-P2
Secondary StructureDisordered
Experimental Method(s)Sequence based prediction; NMR; Fluorescence anisotropy binding assay
Interaction ID21658
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)20361982
CommentsClass II-type PDZ-binding motif in the C-terminal sequence of human Syndecan-1 that binds to the Tiam1 PDZ domain

Record No : 135

Instance ID11659
Regular Expression[YFG][YFHW][WFA]$
Motif InstanceFYA
Bait Uniprot AccessionP18827
Bait Uniprot IdentifierSDC1_HUMAN
Bait Gene NameSDC1
Sequence Position308-310
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Sequence based prediction; Pull down(GST tag)
Interaction ID21659
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9660868
CommentsCOOH-terminal sequence of human syndecan-1 that binds to the PDZ domain of hCASK

Record No : 136

Instance ID11660
Regular Expression[YFG][YFHW][WFA]$
Motif InstanceFYA
Bait Uniprot AccessionP34741
Bait Uniprot IdentifierSDC2_HUMAN
Bait Gene NameSDC2
Sequence Position199-201
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Sequence based prediction; Pull down(GST tag)
Interaction ID21660
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9660868
CommentsCOOH-terminal sequence of human syndecan-2 that binds to the PDZ domain of hCASK

Record No : 137

Instance ID11661
Regular Expression[YFG][YFHW][WFA]$
Motif InstanceFYA
Bait Uniprot AccessionO75056
Bait Uniprot IdentifierSDC3_HUMAN
Bait Gene NameSDC3
Sequence Position440-442
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Sequence based prediction
Interaction ID21661
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9660868
CommentsCOOH-terminal sequence of human syndecan-3 that may bind to the PDZ domain of hCASK

Record No : 138

Instance ID11662
Regular Expression[YFG][YFHW][WFA]$
Motif InstanceFYA
Bait Uniprot AccessionP31431
Bait Uniprot IdentifierSDC4_HUMAN
Bait Gene NameSDC4
Sequence Position196-198
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Sequence based prediction
Interaction ID21662
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9660868
CommentsCOOH-terminal sequence of human syndecan-4 that may bind to the PDZ domain of hCASK

Record No : 139

Instance ID11663
Regular Expression[YFG][YFHW][WFA]$
Motif InstanceFYA
Bait Uniprot AccessionP34741
Bait Uniprot IdentifierSDC2_HUMAN
Bait Gene NameSDC2
Sequence Position199-201
Critical ResiduesP1; P2
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)SPR; Mutational analysis; Y2H; Ligand blotting assay
Interaction ID21663
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9391086
CommentsCOOH-terminal sequence of human syndecan-2 that binds to both PDZ domains of human Syntenin-1

Record No : 140

Instance ID11664
Regular Expression[YFG][YFHW][WFA]$
Motif InstanceFYA
Bait Uniprot AccessionP43407
Bait Uniprot IdentifierSDC2_MOUSE
Bait Gene NameSdc2
Sequence Position200-202
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutational analysis; Y2H
Interaction ID21664
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11018053
CommentsThe C-terminal conserved sequence of mouse syndecan-2 cytoplasmic domain that binds to the mouse Synbindin (Trappc4) and causes the clustering of synbindin in dendritic spines

Record No : 141

Instance ID11665
Regular Expression[YFG][YFHW][WFA]$
Motif InstanceFYA
Bait Uniprot AccessionP34901
Bait Uniprot IdentifierSDC4_RAT
Bait Gene NameSdc4
Sequence Position200-202
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutational analysis; Y2H
Interaction ID21665
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10911369
CommentsClass II-type PDZ-binding motif in the C-terminal sequence of rat cytoplasmic domain of syndecan-4 that binds to the mouse synectin (Gipc1) PDZ domain

Record No : 142

Instance ID11691
Regular ExpressionWx{2,3}[FW]
Motif InstanceWVSF
Bait Uniprot AccessionQ8WXE9
Bait Uniprot IdentifierSTON2_HUMAN
Bait Gene NameSTON2
Sequence Position15-18
Critical ResiduesP1; P4
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutational analysis; Pull down(GST tag)
Interaction ID21691
Interacting DomainAlpha-ear domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14565955, 14726597
CommentsAP-2 interaction motif I(15-18) in human Stonin-2 that mediates binding to the alpha-ear domain of AP-2 complex subunit alpha-1 or Alpha1-adaptin

Record No : 143

Instance ID11692
Regular ExpressionWx{2,3}[FW]
Motif InstanceWVQF
Bait Uniprot AccessionQ8WXE9
Bait Uniprot IdentifierSTON2_HUMAN
Bait Gene NameSTON2
Sequence Position102-105
Critical ResiduesP1; P4
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutational analysis; Pull down(GST tag)
Interaction ID21692
Interacting DomainAlpha-ear domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14565955, 14726597
CommentsAP-2 interaction motif II(102-105) in human Stonin-2 that mediates binding to the alpha-ear domain of AP-2 complex subunit alpha-1 or Alpha1-adaptin

Record No : 144

Instance ID11693
Regular ExpressionWx{2,3}[FW]
Motif InstanceWVTF
Bait Uniprot AccessionQ8WXE9
Bait Uniprot IdentifierSTON2_HUMAN
Bait Gene NameSTON2
Sequence Position232-235
Critical ResiduesP1; P4
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutational analysis; Pull down(GST tag)
Interaction ID21693
Interacting DomainAlpha-ear domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14565955, 14726597
CommentsAP-2 interaction motif III(232-235) in human Stonin-2 that mediates binding to the alpha-ear domain of AP-2 complex subunit alpha-1 or Alpha1-adaptin

Record No : 145

Instance ID11694
Regular ExpressionWx{2,3}[FW]
Motif InstanceWVTF
Bait Uniprot AccessionO43426
Bait Uniprot IdentifierSYNJ1_HUMAN
Bait Gene NameSYNJ1
Sequence Position1481-1484
Critical ResiduesP1; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Pull down(GST tag)
Interaction ID21694
Interacting DomainAlpha-ear domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)14565955
CommentsAP-2 interaction motif in the non-neuronal 170-kDa long splice isoform of synaptojanin 1, termed SJ170, that mediates binding to the alpha-ear domain of AP-2 complex subunit alpha-1 or Alpha1-adaptin and is likely to promote efficient targeting of the polyphosphatase to the assembling clathrin lattice in non-neuronal cells

Record No : 146

Instance ID11701
Regular ExpressionP[KR]RPPxPR
Motif InstancePKRPPPPR
Bait Uniprot AccessionO43426
Bait Uniprot IdentifierSYNJ1_HUMAN
Bait Gene NameSYNJ1
Sequence Position1105-1112
Critical ResiduesP2; P4; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay
Interaction ID21701
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10542231, 9341169
CommentsThe SH3 domain-binding P[KR]RPPxPR motif (1105-1112) in human Synaptojanin-1 that binds the SH3 domain of human Endophilin-1 (SH3GL2)

Record No : 147

Instance ID11702
Regular ExpressionP[KR]RPPxPR
Motif InstancePKRPPPPR
Bait Uniprot AccessionO43426
Bait Uniprot IdentifierSYNJ1_HUMAN
Bait Gene NameSYNJ1
Sequence Position1105-1112
Critical ResiduesP2; P4; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay
Interaction ID21702
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10542231, 9341169
CommentsThe SH3 domain-binding P[KR]RPPxPR motif (1105-1112) in human Synaptojanin-1 that binds the SH3 domain of human Endophilin-2 (SH3GL1)

Record No : 148

Instance ID11703
Regular ExpressionP[KR]RPPxPR
Motif InstancePKRPPPPR
Bait Uniprot AccessionO43426
Bait Uniprot IdentifierSYNJ1_HUMAN
Bait Gene NameSYNJ1
Sequence Position1105-1112
Critical ResiduesP4; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay
Interaction ID21703
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10542231, 9341169
CommentsThe SH3 domain-binding P[KR]RPPxPR motif (1105-1112) in human Synaptojanin-1 that binds the SH3 domain of human Endophilin-3 (SH3GL3)

Record No : 149

Instance ID11704
Regular ExpressionPxxPxR
Motif InstancePIRPSR
Bait Uniprot AccessionO43426
Bait Uniprot IdentifierSYNJ1_HUMAN
Bait Gene NameSYNJ1
Sequence Position1065-1070
Critical ResiduesP3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay
Interaction ID21704
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10542231, 9341169
CommentsThe SH3 domain-binding PxxPxR motif I (1065-1070) in human Synaptojanin-1 that binds the SH3 domain of human Endophilin-1 (SH3GL2)

Record No : 150

Instance ID11705
Regular ExpressionPxxPxR
Motif InstancePIRPSR
Bait Uniprot AccessionO43426
Bait Uniprot IdentifierSYNJ1_HUMAN
Bait Gene NameSYNJ1
Sequence Position1065-1070
Critical ResiduesP3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay
Interaction ID21705
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10542231, 9341169
CommentsThe SH3 domain-binding PxxPxR motif I (1065-1070) in human Synaptojanin-1 that binds the SH3 domain of human Endophilin-2 (SH3GL1)

Record No : 151

Instance ID11706
Regular ExpressionPxxPxR
Motif InstancePIRPSR
Bait Uniprot AccessionO43426
Bait Uniprot IdentifierSYNJ1_HUMAN
Bait Gene NameSYNJ1
Sequence Position1065-1070
Critical ResiduesP3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay
Interaction ID21706
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10542231, 9341169
CommentsThe SH3 domain-binding PxxPxR motif I (1065-1070) in human Synaptojanin-1 that binds the SH3 domain of human Endophilin-3 (SH3GL3)

Record No : 152

Instance ID11707
Regular ExpressionPxxPxR
Motif InstancePIRPSR
Bait Uniprot AccessionO43426
Bait Uniprot IdentifierSYNJ1_HUMAN
Bait Gene NameSYNJ1
Sequence Position1065-1070
Critical ResiduesP4; P6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay
Interaction ID21707
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10542231, 9341169
CommentsThe SH3 domain-binding PxxPxR motif I (1065-1070) in human Synaptojanin-1 that binds the SH3 domain of human Amphiphysin

Record No : 153

Instance ID11708
Regular ExpressionPxxPxR
Motif InstancePAPPQR
Bait Uniprot AccessionO43426
Bait Uniprot IdentifierSYNJ1_HUMAN
Bait Gene NameSYNJ1
Sequence Position1120-1125
Critical ResiduesP4; P6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay
Interaction ID21708
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10542231, 9341169
CommentsThe SH3 domain-binding PxxPxR motif II (1120-1125) in human Synaptojanin-1 that binds the SH3 domain of human Amphiphysin

Record No : 154

Instance ID11709
Regular ExpressionPxxPxR
Motif InstancePTIPPR
Bait Uniprot AccessionO43426
Bait Uniprot IdentifierSYNJ1_HUMAN
Bait Gene NameSYNJ1
Sequence Position1196-1201
Critical ResiduesP4; P6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay
Interaction ID21709
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10542231, 9341169
CommentsThe SH3 domain-binding PxxPxR motif III (1196-1201) in human Synaptojanin-1 that binds the SH3 domain of human Amphiphysin

Record No : 155

Instance ID11710
Regular ExpressionPxxPxR
Motif InstancePQPPPR
Bait Uniprot AccessionO43426
Bait Uniprot IdentifierSYNJ1_HUMAN
Bait Gene NameSYNJ1
Sequence Position1284-1289
Critical ResiduesP4; P6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Phage Display; Peptide Scanning; ELISA; Competition binding assay
Interaction ID21710
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10542231, 9341169
CommentsThe SH3 domain-binding PxxPxR motif IV (1284-1289) in human Synaptojanin-1 that binds the SH3 domain of human Amphiphysin

Record No : 156

Instance ID11723
Regular ExpressionPxxPxR
Motif InstancePPVPPR
Bait Uniprot AccessionQ07889
Bait Uniprot IdentifierSOS1_HUMAN
Bait Gene NameSOS1
Sequence Position1151-1156
Critical ResiduesP1; P4; P6
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)Peptide binding assay; SPR; ITC
Interaction ID21723
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18778683, 8493579, 9383403, 7629138
CommentsThe SH3 domain-binding PxxPxR motif 2 (1151-1156) in human hSos1 protein that binds to the SH3 domains of human adapter protein GRB2 for the transduction of signals from receptor tyrosine kinases to Ras

Record No : 157

Instance ID11724
Regular ExpressionPxxPxR
Motif InstancePAIPPR
Bait Uniprot AccessionQ07889
Bait Uniprot IdentifierSOS1_HUMAN
Bait Gene NameSOS1
Sequence Position1180-1185
Critical ResiduesP1; P4; P6
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)Peptide binding assay
Interaction ID21724
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8493579, 9383403, 7629138
CommentsThe SH3 domain-binding PxxPxR motif 3 (1180-1185) in human hSos1 protein that binds to the SH3 domains of human adapter protein GRB2 for the transduction of signals from receptor tyrosine kinases to Ras

Record No : 158

Instance ID11725
Regular ExpressionPxxPxR
Motif InstancePLLPPR
Bait Uniprot AccessionQ07889
Bait Uniprot IdentifierSOS1_HUMAN
Bait Gene NameSOS1
Sequence Position1212-1217
Critical ResiduesP1; P4; P6
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)Peptide binding assay
Interaction ID21725
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8493579, 9383403, 7629138
CommentsThe SH3 domain-binding PxxPxR motif 4 (1212-1217) in human hSos1 protein that binds to the SH3 domains of human adapter protein GRB2 for the transduction of signals from receptor tyrosine kinases to Ras

Record No : 159

Instance ID11726
Regular ExpressionPxxPxR
Motif InstancePPVPPR
Bait Uniprot AccessionQ07889
Bait Uniprot IdentifierSOS1_HUMAN
Bait Gene NameSOS1
Sequence Position1290-1295
Critical ResiduesP1; P4; P6
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)Peptide binding assay
Interaction ID21726
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8493579, 9383403, 7629138
CommentsThe SH3 domain-binding PxxPxR motif 6 (1290-1295) in human hSos1 protein that binds to the SH3 domains of human adapter protein GRB2 for the transduction of signals from receptor tyrosine kinases to Ras

Record No : 160

Instance ID11727
Regular ExpressionPxxPxR
Motif InstancePPLPPR
Bait Uniprot AccessionQ07890
Bait Uniprot IdentifierSOS2_HUMAN
Bait Gene NameSOS2
Sequence Position1147-1152
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID21727
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)7629138
CommentsThe SH3 domain-binding PxxPxR motif I (1147-1152) in human hSos2 protein that binds to the SH3 domains of human adapter protein GRB2

Record No : 161

Instance ID11728
Regular ExpressionPxxPxR
Motif InstancePAIPPR
Bait Uniprot AccessionQ07890
Bait Uniprot IdentifierSOS2_HUMAN
Bait Gene NameSOS2
Sequence Position1173-1178
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID21728
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)7629138
CommentsThe SH3 domain-binding PxxPxR motif II (1173-1178) in human hSos2 protein that binds to the SH3 domains of human adapter protein GRB2

Record No : 162

Instance ID11729
Regular ExpressionPxxPxR
Motif InstancePPPPPR
Bait Uniprot AccessionQ07890
Bait Uniprot IdentifierSOS2_HUMAN
Bait Gene NameSOS2
Sequence Position1204-1209
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID21729
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)7629138
CommentsThe SH3 domain-binding PxxPxR motif III (1204-1209) in human hSos2 protein that binds to the SH3 domains of human adapter protein GRB2

Record No : 163

Instance ID11730
Regular ExpressionPxxPxR
Motif InstancePPVPLR
Bait Uniprot AccessionQ07890
Bait Uniprot IdentifierSOS2_HUMAN
Bait Gene NameSOS2
Sequence Position1217-1222
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID21730
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)7629138
CommentsThe SH3 domain-binding PxxPxR motif IV (1217-1222) in human hSos2 protein that binds to the SH3 domains of human adapter protein GRB2

Record No : 164

Instance ID11731
Regular ExpressionPxxPxR
Motif InstancePPVPPR
Bait Uniprot AccessionQ07890
Bait Uniprot IdentifierSOS2_HUMAN
Bait Gene NameSOS2
Sequence Position1290-1295
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID21731
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)7629138
CommentsThe SH3 domain-binding PxxPxR motif V (1290-1295) in human hSos2 protein that binds to the SH3 domains of human adapter protein GRB2

Record No : 165

Instance ID11739
Regular ExpressionxPxxP
Motif InstancePPQKP
Bait Uniprot AccessionP09951
Bait Uniprot IdentifierSYN1_RAT
Bait Gene NameSyn1
Sequence Position588-592
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; Pull down(GST tag); Competition binding assay
Interaction ID21739
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8022809, 10899172
CommentsThe SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domains of human adapter protein GRB2

Record No : 166

Instance ID11740
Regular ExpressionxPxxP
Motif InstanceGPPHP
Bait Uniprot AccessionP09951
Bait Uniprot IdentifierSYN1_RAT
Bait Gene NameSyn1
Sequence Position653-657
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; Pull down(GST tag); Competition binding assay
Interaction ID21740
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10899172
CommentsThe SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domain of human Amphiphysin I

Record No : 167

Instance ID11741
Regular ExpressionxPxxP
Motif InstanceGPAGP
Bait Uniprot AccessionP09951
Bait Uniprot IdentifierSYN1_RAT
Bait Gene NameSyn1
Sequence Position594-598
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; Pull down(GST tag); Competition binding assay
Interaction ID21741
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10899172
CommentsThe SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domain of human Amphiphysin II

Record No : 168

Instance ID11742
Regular ExpressionxPxxP
Motif InstanceRPSGP
Bait Uniprot AccessionP09951
Bait Uniprot IdentifierSYN1_RAT
Bait Gene NameSyn1
Sequence Position620-624
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; Pull down(GST tag); Competition binding assay
Interaction ID21742
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10899172
CommentsThe SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domain of human Amphiphysin II

Record No : 169

Instance ID11743
Regular ExpressionxPxxP
Motif InstanceRPTKP
Bait Uniprot AccessionP09951
Bait Uniprot IdentifierSYN1_RAT
Bait Gene NameSyn1
Sequence Position629-633
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; Pull down(GST tag); Competition binding assay
Interaction ID21743
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10899172
CommentsThe SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domain of human Amphiphysin II

Record No : 170

Instance ID11744
Regular ExpressionxPxxP
Motif InstancePPQKP
Bait Uniprot AccessionP09951
Bait Uniprot IdentifierSYN1_RAT
Bait Gene NameSyn1
Sequence Position588-592
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; Pull down(GST tag); Competition binding assay
Interaction ID21744
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10899172
CommentsThe SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domain of chicken c-Src

Record No : 171

Instance ID11745
Regular ExpressionxPxxP
Motif InstanceGPGAP
Bait Uniprot AccessionP09951
Bait Uniprot IdentifierSYN1_RAT
Bait Gene NameSyn1
Sequence Position537-541
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; Pull down(GST tag); Competition binding assay
Interaction ID21745
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10899172
CommentsThe SH3 domain-binding xPxxP motif in rat Synapsin I that may bind the SH3 domain of human Phospholipase C-gamma-1

Record No : 172

Instance ID11746
Regular ExpressionxPxxP
Motif InstancePPQKP
Bait Uniprot AccessionP17599
Bait Uniprot IdentifierSYN1_BOVIN
Bait Gene NameSYN1
Sequence Position590-594
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID21746
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10899172
CommentsThe SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domains of human adapter protein GRB2

Record No : 173

Instance ID11747
Regular ExpressionxPxxP
Motif InstanceGPPHP
Bait Uniprot AccessionP17599
Bait Uniprot IdentifierSYN1_BOVIN
Bait Gene NameSYN1
Sequence Position655-659
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID21747
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10899172
CommentsThe SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domain of human Amphiphysin I

Record No : 174

Instance ID11748
Regular ExpressionxPxxP
Motif InstanceGPAGP
Bait Uniprot AccessionP17599
Bait Uniprot IdentifierSYN1_BOVIN
Bait Gene NameSYN1
Sequence Position596-600
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID21748
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10899172
CommentsThe SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domain of human Amphiphysin II

Record No : 175

Instance ID11749
Regular ExpressionxPxxP
Motif InstanceRPSGP
Bait Uniprot AccessionP17599
Bait Uniprot IdentifierSYN1_BOVIN
Bait Gene NameSYN1
Sequence Position622-626
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID21749
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10899172
CommentsThe SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domain of human Amphiphysin II

Record No : 176

Instance ID11750
Regular ExpressionxPxxP
Motif InstanceRPTKP
Bait Uniprot AccessionP17599
Bait Uniprot IdentifierSYN1_BOVIN
Bait Gene NameSYN1
Sequence Position631-635
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID21750
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10899172
CommentsThe SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domain of human Amphiphysin II

Record No : 177

Instance ID11751
Regular ExpressionxPxxP
Motif InstancePPQKP
Bait Uniprot AccessionP17599
Bait Uniprot IdentifierSYN1_BOVIN
Bait Gene NameSYN1
Sequence Position590-594
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID21751
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10899172
CommentsThe SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domain of chicken c-Src

Record No : 178

Instance ID11752
Regular ExpressionxPxxP
Motif InstanceGPGAP
Bait Uniprot AccessionP17599
Bait Uniprot IdentifierSYN1_BOVIN
Bait Gene NameSYN1
Sequence Position539-543
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID21752
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10899172
CommentsThe SH3 domain-binding xPxxP motif in bovine Synapsin I that may bind the SH3 domain of human Phospholipase C-gamma-1

Record No : 179

Instance ID11767
Regular ExpressionPPxPxKxK
Motif InstancePPVPPKPK
Bait Uniprot AccessionQ9UPX8
Bait Uniprot IdentifierSHAN2_HUMAN
Bait Gene NameSHANK2
Sequence Position1165-1172
Critical ResiduesP8
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)NMR; CD; ITC
Interaction ID21767
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19921743
CommentsThe SH3 domain-binding motif in human SHANK2 that binds the murine cortactin SH3 domain

Record No : 180

Instance ID11778
Regular ExpressionPxPxPR
Motif InstancePSPSPR
Bait Uniprot AccessionQ8TBC3
Bait Uniprot IdentifierSHKB1_HUMAN
Bait Gene NameSHKBP1
Sequence Position621-626
Critical ResiduesP6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Site-directed mutagenesis
Interaction ID21778
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12874286, 11152963
CommentsA novel polyproline-arginine motif (PXXXPR) in human SH3KBP1-binding protein 1 that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA)

Record No : 181

Instance ID11779
Regular ExpressionPxPxPR
Motif InstancePSPSPR
Bait Uniprot AccessionQ6P7W2
Bait Uniprot IdentifierSHKB1_MOUSE
Bait Gene NameShkbp1
Sequence Position618-623
Critical ResiduesP6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Site-directed mutagenesis
Interaction ID21779
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12874286, 11152963
CommentsA novel polyproline-arginine motif (PXXXPR) [618-623] in mouse SETA-binding protein 1 that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA)

Record No : 182

Instance ID11780
Regular ExpressionPxPxPR
Motif InstancePTPAPR
Bait Uniprot AccessionQ6P7W2
Bait Uniprot IdentifierSHKB1_MOUSE
Bait Gene NameShkbp1
Sequence Position678-683
Critical ResiduesP6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Site-directed mutagenesis
Interaction ID21780
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12874286, 11152963
CommentsA novel polyproline-arginine motif (PXXXPR) [678-683] in mouse SETA-binding protein 1 that may be specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85 or SETA)

Record No : 183

Instance ID11803
Regular Expression[LI]xCxE
Motif InstanceLTCEE
Bait Uniprot AccessionQ3TKT4
Bait Uniprot IdentifierSMCA4_MOUSE
Bait Gene NameSmarca4
Sequence Position1324-1328
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis
Interaction ID21803
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)7923370
CommentsThe Rb-binding LXCXE motif of the mouse Transcription activator BRG1 that is necessary for binding to the mouse Retinoblastoma-associated protein (Rb1)

Record No : 184

Instance ID11804
Regular Expression[LI]xCxE
Motif InstanceLTCEE
Bait Uniprot AccessionP51532
Bait Uniprot IdentifierSMCA4_HUMAN
Bait Gene NameSMARCA4
Sequence Position1357-1361
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis
Interaction ID21804
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8657132, 7923370
CommentsThe Rb-binding LXCXE motif of the human Transcription activator BRG1 that is necessary for binding to the human Retinoblastoma-associated protein (RB1)

Record No : 185

Instance ID11823
Regular ExpressionNITVK
Motif InstanceNITVK
Bait Uniprot AccessionP16952
Bait Uniprot IdentifierSSP5_STRGN
Bait Gene Namessp5
Sequence Position1182-1186
Critical ResiduesP1; P4
Motif PTM(s)Unknown
Secondary StructureBeta sheet
Experimental Method(s)Site-directed mutagenesis
Interaction ID21823
Interacting DomainUnknown
Disease Association(s)Periodontitis
Inhibitor(s)Unknown
Reference(s)11500450, 15972485
CommentsNITVK motif of the cell surface protein SspB of Streptococcus gordonii that is required for binding the Mfa1 major structural subunit protein of the short fimbriae of Porphyromonas gingivalisis for coadhesion and biofilm development between these organisms

Record No : 186

Instance ID11824
Regular ExpressionVxxLL
Motif InstanceVQDLL
Bait Uniprot AccessionP16952
Bait Uniprot IdentifierSSP5_STRGN
Bait Gene Namessp5
Sequence Position1174-1178
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Competitive inhibition of P. gingivalis adherence and biofilm formation by synthetic peptide
Interaction ID21824
Interacting DomainUnknown
Disease Association(s)Periodontitis
Inhibitor(s)Unknown
Reference(s)18474648, 15972485
CommentsThe VxxLL region of the cell surface protein SspB of Streptococcus gordonii that contributes to its interaction with the Mfa1 major structural subunit protein of the short fimbriae of Porphyromonas gingivalisis for coadhesion and biofilm development between these organisms

Record No : 187

Instance ID11831
Regular ExpressionR[ST][ST]SL
Motif InstanceRTSSL
Bait Uniprot AccessionC7GQJ8
Bait Uniprot IdentifierC7GQJ8_YEAS2
Bait Gene NameSTE5
Sequence Position117-121
Critical ResiduesP1; P2; P4; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Peptide binding assay; Mutational analysis
Interaction ID21831
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18280496
CommentsThe consensus R[ST][ST]SL motif in Ste5p of Saccharomyces cerevisiae (strain JAY291) that is necessary, but not sufficient for binding to the Fus1p SH3 domain

Record No : 188

Instance ID11838
Regular ExpressionISxPx{2,4}FxHxxHVGxD
Motif InstanceISTPYNAKHIHHVGVD
Bait Uniprot AccessionQ03497
Bait Uniprot IdentifierSTE20_YEAST
Bait Gene NameSTE20
Sequence Position337-352
Critical ResiduesP2; P9; P12
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis
Interaction ID21838
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11940652, 12586692, 9601050, 7493928
CommentsThe Cdc42/Rac interactive binding (CRIB) motif in the Saccharomyces cerevisiae kinase Ste20 that forms a minimal consensus for functionally interacting with Cdc42 in a GTP-dependent manner

Record No : 189

Instance ID11842
Regular ExpressionPPGx[RK]
Motif InstancePPGMR
Bait Uniprot AccessionP14678
Bait Uniprot IdentifierRSMB_HUMAN
Bait Gene NameSNRPB
Sequence Position192-196
Critical ResiduesP1; P2; P3
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)NMR shift mapping; SPOT Analysis
Interaction ID21842
Interacting DomainGYF domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15105431, 16000308
CommentsProline-rich sequences (192-196) in human Small nuclear ribonucleoprotein-associated proteins B and B' that serves as a recognition motif for the GYF domain of the cellular adapter protein CD2BP2

Record No : 190

Instance ID11843
Regular ExpressionPPGx[RK]
Motif InstancePPGMR
Bait Uniprot AccessionP14678
Bait Uniprot IdentifierRSMB_HUMAN
Bait Gene NameSNRPB
Sequence Position217-221
Critical ResiduesP1; P2; P3
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)NMR shift mapping; SPOT Analysis
Interaction ID21843
Interacting DomainGYF domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15105431, 16000308
CommentsProline-rich sequences (217-221) in human Small nuclear ribonucleoprotein-associated proteins B and B' that serves as a recognition motif for the GYF domain of the cellular adapter protein CD2BP2

Record No : 191

Instance ID11844
Regular ExpressionPPGx[RK]
Motif InstancePPGMR
Bait Uniprot AccessionP14678
Bait Uniprot IdentifierRSMB_HUMAN
Bait Gene NameSNRPB
Sequence Position224-228
Critical ResiduesP1; P2; P3
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)NMR shift mapping; SPOT Analysis
Interaction ID21844
Interacting DomainGYF domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15105431, 16000308
CommentsProline-rich sequences (224-228) in human Small nuclear ribonucleoprotein-associated proteins B and B' that serves as a recognition motif for the GYF domain of the cellular adapter protein CD2BP2

Record No : 192

Instance ID11849
Regular ExpressionFGPxL
Motif InstanceFGPAL
Bait Uniprot AccessionQ96FS4
Bait Uniprot IdentifierSIPA1_HUMAN
Bait Gene NameSIPA1
Sequence Position486-490
Critical ResiduesP1; P2; P3
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)Phage Display; SPOT Analysis
Interaction ID21849
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15845542
CommentsThe consensus motif in human Signal-induced proliferation-associated protein 1 that represent putative target sites for binding of Cyclophilin A, a peptidyl-prolyl cis/trans-isomerase that is involved in multiple signaling events of eukaryotic cells

Record No : 193

Instance ID11858
Regular Expression[ND]xY[ST]xxP
Motif InstanceNEYTEGP
Bait Uniprot AccessionO43597
Bait Uniprot IdentifierSPY2_HUMAN
Bait Gene NameSPRY2
Sequence Position53-59
Critical ResiduesP1; P3; P7
Motif PTM(s)Phosphorylation at Tyr-P3
Secondary StructureUnknown
Experimental Method(s)Mutational analysis
Interaction ID21858
Interacting DomainTKB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12815057
CommentsConsensus sequence for phosphotyrosine recognition by the c-Cbl TKB domain in human protein Sprouty homolog 2 and this high affinity interaction is critical for its physiological function in a signal-specific context

Record No : 194

Instance ID11859
Regular ExpressionNxY[STEQ]
Motif InstanceNEYT
Bait Uniprot AccessionP12931
Bait Uniprot IdentifierSRC_HUMAN
Bait Gene NameSRC
Sequence Position417-420
Critical ResiduesP3
Motif PTM(s)Phosphorylation at Tyr-P3
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Sequence based prediction
Interaction ID21859
Interacting DomainTKB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15737992, 11448952
CommentsConsensus sequence for phosphotyrosine recognition by the Cbl TKB domain in human Proto-oncogene tyrosine-protein kinase Src where c-Cbl acts as a ubiquitin ligase thus down-regulating Src

Record No : 195

Instance ID11861
Regular ExpressionNxY[STEQ]
Motif InstanceNPYE
Bait Uniprot AccessionP43405
Bait Uniprot IdentifierKSYK_HUMAN
Bait Gene NameSYK
Sequence Position321-324
Critical ResiduesP3
Motif PTM(s)Phosphorylation at Tyr-P3
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Competition binding assay
Interaction ID21861
Interacting DomainTKB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15737992, 9857068
CommentsConsensus sequence for phosphotyrosine recognition by the Cbl TKB domain in human Tyrosine-protein kinase SYK that plays a critical role in the recruitment of Cbl to Syk and in Cbl-mediated negative regulation of Syk

Record No : 196

Instance ID11863
Regular ExpressionRA[VI]xNQY[ST]
Motif InstanceRAVENQYS
Bait Uniprot AccessionO14492
Bait Uniprot IdentifierSH2B2_HUMAN
Bait Gene NameSH2B2
Sequence Position623-630
Critical ResiduesP1; P2; P3; P5; P7
Motif PTM(s)Phosphorylation at Tyr-P7
Secondary StructureExtended conformation
Experimental Method(s)X-ray crystallography; Site-directed mutagenesis; ITC
Interaction ID21863
Interacting DomainTKB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15737992
CommentsNovel Cbl phosphotyrosine recognition motif in SH2B adapter protein 2 (APS) that serves as a binding site for the Cbl TKB domain and allows Cbl ito be recruited to and phosphorylated by the insulin receptor in adipose cells through the adapter protein APS

Record No : 197

Instance ID11943
Regular ExpressionY[VI]N
Motif InstanceYVN
Bait Uniprot AccessionP29353
Bait Uniprot IdentifierSHC1_HUMAN
Bait Gene NameSHC1
Sequence Position427-429
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureUnknown
Experimental Method(s)Peptide binding assay
Interaction ID21943
Interacting DomainSH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8491186
CommentsThe short sequence motif present in SHC-transforming protein 1 that specifically binds the SH2 domain of Growth factor receptor-bound protein 2 with high affinity

Record No : 198

Instance ID11966
Regular ExpressionPxxxRxxKP
Motif InstancePVVDRSLKP
Bait Uniprot AccessionQ9CQ26
Bait Uniprot IdentifierSTABP_MOUSE
Bait Gene NameStambp
Sequence Position231-239
Critical ResiduesP5; P8
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)SPOT Analysis
Interaction ID21966
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12176364
CommentsThe high-affinity atypical R-X-X-K binding motif in mouse STAM-binding protein for binding the Gads SH3 Domain

Record No : 199

Instance ID11974
Regular ExpressionNxI
Motif InstanceNAI
Bait Uniprot AccessionQ9BQB4
Bait Uniprot IdentifierSOST_HUMAN
Bait Gene NameSOST
Sequence Position117-119
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; Mutational analysis; Competition binding assay; BLI; ELISA
Interaction ID21974
Interacting DomainE1 domain
Disease Association(s)Bone dysplasia
Inhibitor(s)Unknown
Reference(s)21944579
CommentsThe NxI peptide motif in the Wnt pathway inhibitor Sclerostin (SOST) that is important for binding to the E1 propeller domain of Wnt coreceptor LRP6 and for inhibitory function

Record No : 200

Instance ID11975
Regular ExpressionNxI
Motif InstanceNWI
Bait Uniprot AccessionQ6X4U4
Bait Uniprot IdentifierSOSD1_HUMAN
Bait Gene NameSOSTDC1
Sequence Position112-114
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; ELISA
Interaction ID21975
Interacting DomainE1 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)21944579, 12900447
CommentsThe NxI peptide motif in the Wnt pathway inhibitor WISE (SOSTDC1) that is important for binding to the E1 propeller domain of Wnt coreceptor LRP6

Record No : 201

Instance ID11993
Regular ExpressionPPxY
Motif InstancePPRY
Bait Uniprot AccessionP08363
Bait Uniprot IdentifierVP8_BTV10
Bait Gene NameS10
Sequence Position36-39
Critical ResiduesP1; P2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID21993
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16352570
CommentsNon-structural protein NS3 (S10) of Bluetongue virus (BTV) harbors a PPXY late-domain motif that allows NS3 to bind Human NEDD4-like E3 ubiquitin-protein ligase WWP1

Record No : 202

Instance ID11994
Regular ExpressionPPxY
Motif InstancePPRY
Bait Uniprot AccessionP08363
Bait Uniprot IdentifierVP8_BTV10
Bait Gene NameS10
Sequence Position36-39
Critical ResiduesP1; P2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID21994
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16352570
CommentsNon-structural protein NS3 (S10) of Bluetongue virus (BTV) harbors a PPXY late-domain motif that allows NS3 to bind Human E3 ubiquitin-protein ligase Itchy homolog (ITCH)

Record No : 203

Instance ID12011
Regular ExpressionLxHxTxxRPKx{6,6}P
Motif InstanceLSHPTTSRPKATGRRPP
Bait Uniprot AccessionQ96B97
Bait Uniprot IdentifierSH3K1_HUMAN
Bait Gene NameSH3KBP1
Sequence Position476-492
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; Competition binding
Interaction ID22011
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16707503, 12690097
CommentsThe motif present in human CIN85/SH3KBP1 that is sufficient for binding to human F-actin-capping protein subunit alpha-1 (CapZ alpha-1)

Record No : 204

Instance ID12012
Regular ExpressionLxHxTxxRPKx{6,6}P
Motif InstanceLSHPTTSRPKATGRRPP
Bait Uniprot AccessionQ96B97
Bait Uniprot IdentifierSH3K1_HUMAN
Bait Gene NameSH3KBP1
Sequence Position476-492
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; Competition binding
Interaction ID22012
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16707503, 12690097
CommentsThe motif present in human CIN85/SH3KBP1 that is sufficient for binding to human F-actin-capping protein subunit alpha-2 (CapZ alpha-2)

Record No : 205

Instance ID12013
Regular ExpressionLxHxTxxRPKx{6,6}P
Motif InstanceLSHPTTSRPKATGRRPP
Bait Uniprot AccessionQ96B97
Bait Uniprot IdentifierSH3K1_HUMAN
Bait Gene NameSH3KBP1
Sequence Position476-492
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; Competition binding
Interaction ID22013
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16707503, 12690097
CommentsThe motif present in human CIN85/SH3KBP1 that is sufficient for binding to human F-actin-capping protein subunit beta (CapZ beta)

Record No : 206

Instance ID12043
Regular ExpressionFxxxVQxLTG
Motif InstanceFRELVQELTG
Bait Uniprot AccessionQ9LDH1
Bait Uniprot IdentifierSIB1_ARATH
Bait Gene NameSIB1
Sequence Position58-67
Critical ResiduesP5; P6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H
Interaction ID22043
Interacting DomainWRKY domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)22535423, 21990940
CommentsThe VQ-motif in Sigma factor binding protein 1 (SIB1) of Arabidopsis thaliana that interacts specifically with the C-terminal WRKY domain of Arabidopsis WRKY transcription factor 33 (WRKY33)

Record No : 207

Instance ID12044
Regular ExpressionFxxxVQxLTG
Motif InstanceFRELVQELTG
Bait Uniprot AccessionO80669
Bait Uniprot IdentifierSIB2_ARATH
Bait Gene NameSIB2
Sequence Position55-64
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H
Interaction ID22044
Interacting DomainWRKY domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)22535423, 21990940
CommentsThe VQ-motif in Sigma factor binding protein 2 (SIB2) of Arabidopsis thaliana that interacts specifically with the C-terminal WRKY domain of Arabidopsis WRKY transcription factor 33 (WRKY33)

Record No : 208

Instance ID12058
Regular Expressionxxx[ST]x[ACVILF]$
Motif InstanceSKEAYI
Bait Uniprot AccessionP31648
Bait Uniprot IdentifierSC6A1_MOUSE
Bait Gene NameSlc6a1
Sequence Position594-599
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Pull down
Interaction ID22058
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)25305483
CommentsC-terminal class 1 PDZ-binding motif in mouse Sodium- and chloride-dependent GABA transporter 1 (Slc6a1) that binds to the PDZ domains of mouse Multiple PDZ domain protein (Mpdz)

Record No : 209

Instance ID12059
Regular Expressionxxx[ST]x[ACVILF]$
Motif InstanceEKETHL
Bait Uniprot AccessionP31651
Bait Uniprot IdentifierS6A12_MOUSE
Bait Gene NameSlc6a12
Sequence Position609-614
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Pull down
Interaction ID22059
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)25305483
CommentsC-terminal class 1 PDZ-binding motif in mouse Sodium- and chloride-dependent GABA transporter 2 (Slc6a12) that binds to the PDZ domains of mouse Multiple PDZ domain protein (Mpdz)

Record No : 210

Instance ID12060
Regular Expressionxxx[ST]x[ACVILF]$
Motif InstanceEKETHF
Bait Uniprot AccessionP31650
Bait Uniprot IdentifierS6A11_MOUSE
Bait Gene NameSlc6a11
Sequence Position622-627
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Pull down
Interaction ID22060
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)25305483
CommentsC-terminal class 1 PDZ-binding motif in mouse Sodium- and chloride-dependent GABA transporter 3 (Slc6a11) that binds to the PDZ domains of mouse Multiple PDZ domain protein (Mpdz)

Record No : 211

Instance ID12061
Regular Expressionxxx[ST]x[ACVILF]$
Motif InstanceFQDSRI
Bait Uniprot AccessionP28571
Bait Uniprot IdentifierSC6A9_MOUSE
Bait Gene NameSlc6a9
Sequence Position687-692
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Pull down
Interaction ID22061
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)25305483
CommentsC-terminal class 1 PDZ-binding motif in mouse Sodium- and chloride-dependent glycine transporter 1 (Slc6a9) that binds to the PDZ domains of mouse Multiple PDZ domain protein (Mpdz)

Record No : 212

Instance ID12062
Regular Expressionxxx[ST]x[ACVILF]$
Motif InstanceELGTQC
Bait Uniprot AccessionQ761V0
Bait Uniprot IdentifierSC6A5_MOUSE
Bait Gene NameSlc6a5
Sequence Position794-799
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Pull down
Interaction ID22062
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)25305483
CommentsC-terminal class 1 PDZ-binding motif in mouse Sodium- and chloride-dependent glycine transporter 2 (Slc6a5) that binds to the PDZ domains of mouse Multiple PDZ domain protein (Mpdz)

Record No : 213

Instance ID12063
Regular ExpressionPxxPx[KR]
Motif InstancePPPPVR
Bait Uniprot AccessionQ62634
Bait Uniprot IdentifierVGLU1_RAT
Bait Gene NameSlc17a7
Sequence Position553-558
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID22063
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)25334008
CommentsThe second SH3 domain of Rat actin cytoskeletal adaptor protein Nck1 binds to a proline-rich sequence present in the C terminus of Rat Vesicular glutamate transporter 1 (VGluT1) or Slc17a7

Record No : 214

Instance ID12064
Regular ExpressionPxxPx[KR]
Motif InstancePPPPVR
Bait Uniprot AccessionQ62634
Bait Uniprot IdentifierVGLU1_RAT
Bait Gene NameSlc17a7
Sequence Position553-558
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID22064
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)25334008
CommentsThe SH3 domain of Rat Sorbin and SH3 domain-containing protein 1 (Sorbs1) or Ponsin binds to a proline-rich sequence present in the C terminus of Rat Vesicular glutamate transporter 1 (VGluT1) or Slc17a7

Record No : 215

Instance ID12065
Regular ExpressionPxxPx[KR]
Motif InstancePPPPVR
Bait Uniprot AccessionQ62634
Bait Uniprot IdentifierVGLU1_RAT
Bait Gene NameSlc17a7
Sequence Position553-558
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID22065
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)25334008
CommentsThe SH3 domain of Rat Tyrosine-protein kinase Lyn binds to a proline-rich sequence present in the C terminus of Rat Vesicular glutamate transporter 1 (VGluT1) or Slc17a7

Record No : 216

Instance ID12066
Regular ExpressionPPxY
Motif InstancePPSY
Bait Uniprot AccessionQ62634
Bait Uniprot IdentifierVGLU1_RAT
Bait Gene NameSlc17a7
Sequence Position538-541
Critical ResiduesP2; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID22066
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)25334008
CommentsThe PPXY motif of Rat Vesicular glutamate transporter 1 (VGluT1) or Slc17a7 that binds to the WW domain of Rat HECT domain E3 ubiquitin ligase Atrophin Interacting Protein AIP4/Itch

Record No : 217

Instance ID12067
Regular ExpressionPPxY
Motif InstancePPSY
Bait Uniprot AccessionQ62634
Bait Uniprot IdentifierVGLU1_RAT
Bait Gene NameSlc17a7
Sequence Position538-541
Critical ResiduesP2; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID22067
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)25334008
CommentsThe PPXY motif of Rat Vesicular glutamate transporter 1 (VGluT1) or Slc17a7 that binds to the WW domain of Rat E3 ubiquitin-protein ligase Nedd4

Record No : 218

Instance ID12142
Regular Expression[KRHN][SVIL]x[FXY]
Motif InstanceKLDY
Bait Uniprot AccessionQ14160
Bait Uniprot IdentifierSCRIB_HUMAN
Bait Gene NameSCRIB
Sequence Position1265-1268
Critical ResiduesP2; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID22142
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)23359326
CommentsPP1-binding motif of human Protein Scribble (SCRIB) that binds to human protein phosphatase PP1-gamma catalytic subunit (PPP1CC)

Record No : 219

Instance ID12146
Regular ExpressionGxxxxGK[TS]
Motif InstanceGPVRTGKS
Bait Uniprot AccessionQ182W3
Bait Uniprot IdentifierSP4A_PEPD6
Bait Gene NamespoIVA
Sequence Position23-30
Critical ResiduesP7
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Affinity purification
Interaction ID22146
Interacting DomainLysM domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)23292781
CommentsThe Walker A ATP-binding motif in Stage IV sporulation protein A (SpoIVA) of Clostridium difficile interacts with the LysM domain of Spore coat protein SipL

Record No : 220

Instance ID12159
Regular ExpressionGS[QR]TPx[YQ]
Motif InstanceGSRTPMY
Bait Uniprot AccessionO00267
Bait Uniprot IdentifierSPT5H_HUMAN
Bait Gene NameSUPT5H
Sequence Position781-787
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Thr-P4
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography
Interaction ID22159
Interacting DomainPlus3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)24101474
CommentsThe Plus3 domain of human RNA polymerase-associated protein RTF1 recognizes and binds to the C-terminal repeat (CTR) motif of human Transcription elongation factor SPT5

Record No : 221

Instance ID12160
Regular ExpressionFYSPPE
Motif InstanceFYSPPE
Bait Uniprot AccessionQ14849
Bait Uniprot IdentifierSTAR3_HUMAN
Bait Gene NameSTARD3
Sequence Position207-212
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID22160
Interacting DomainMSP domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)24105263
CommentsFFAT-like motif in human StAR-related lipid transfer protein 3 (STARD3) that allows it to interact directly with the MSP domain of human Vesicle-associated membrane protein-associated protein A (VAPA)

Record No : 222

Instance ID12161
Regular ExpressionFYSPPE
Motif InstanceFYSPPE
Bait Uniprot AccessionQ14849
Bait Uniprot IdentifierSTAR3_HUMAN
Bait Gene NameSTARD3
Sequence Position207-212
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID22161
Interacting DomainMSP domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)24105263
CommentsFFAT-like motif in human StAR-related lipid transfer protein 3 (STARD3) that allows it to interact directly with the MSP domain of human Vesicle-associated membrane protein-associated protein B/C (VAPB)

Record No : 223

Instance ID12162
Regular ExpressionFYSPPE
Motif InstanceFYSPPE
Bait Uniprot AccessionO95772
Bait Uniprot IdentifierMENTO_HUMAN
Bait Gene NameSTARD3NL
Sequence Position208-213
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID22162
Interacting DomainMSP domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)24105263
CommentsFFAT-like motif in human STARD3 N-terminal-like protein/MLN64 N-terminal domain homolog (STARD3NL/MENTHO) that allows it to interact directly with the MSP domain of human Vesicle-associated membrane protein-associated protein A (VAPA)

Record No : 224

Instance ID12164
Regular Expression[LIVY]R[KRW][RKL]Rxxx[FKLY]
Motif InstanceLRRRRLQKL
Bait Uniprot AccessionQ86TM6
Bait Uniprot IdentifierSYVN1_HUMAN
Bait Gene NameSYVN1
Sequence Position603-611
Critical ResiduesP2; P5
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Mutation analysis; Co-IP; Pull down(GST tag); NMR; ITC
Interaction ID22164
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)24100225
CommentsThe VCP-binding motif (VBM) in Human E3 ubiquitin-protein ligase synoviolin (SYVN1) that is critical for binding to human Transitional endoplasmic reticulum ATPase VCP

Record No : 225

Instance ID12165
Regular ExpressionRx{0,3}AxAAxxR
Motif InstanceRAKLAEAAERR
Bait Uniprot AccessionP0C0A9
Bait Uniprot IdentifierSVIP_RAT
Bait Gene NameSvip
Sequence Position22-32
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureCoil
Experimental Method(s)Sequence based prediction; Pull down(GST tag)
Interaction ID22165
Interacting DomainND1 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12529442
CommentsThe VCP-interacting motif (VIM) in rat Small VCP/p97-interacting protein (Svip) that mediates interaction with rat Transitional endoplasmic reticulum ATPase (Vcp)

Record No : 226

Instance ID12194
Regular ExpressionKKKK
Motif InstanceKKKK
Bait Uniprot AccessionP21707
Bait Uniprot IdentifierSYT1_RAT
Bait Gene NameSyt1
Sequence Position324-327
Critical ResiduesP1; P2; P3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID22194
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)24472545
CommentsThe polylysine KKKK motif in rat Synaptotagmin I (Syt1) that is responsible for interaction with rat Ras-related protein Rab3a



© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)