Total : 28 Records


Record No : 1

Instance ID10599
Regular Expressionxx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x
Motif InstanceSTLNPQAPEFILG
Bait Uniprot AccessionQ14694
Bait Uniprot IdentifierUBP10_HUMAN
Bait Gene NameUSP10
Sequence Position81-93
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)SPR
Interaction ID20599
Interacting DomainMLLE domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16554297
CommentsThe MLLE/PABC domain of human Polyadenylate-binding protein 1 (PABP1/PABPC1/PABPC2) binds to the N-terminal PAM2 motif of human Ubiquitin carboxyl-terminal hydrolase 10 (USP10)

Record No : 2

Instance ID10600
Regular Expressionxx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x
Motif InstanceSTLNPQAPEFILG
Bait Uniprot AccessionQ14694
Bait Uniprot IdentifierUBP10_HUMAN
Bait Gene NameUSP10
Sequence Position81-93
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)ITC
Interaction ID20600
Interacting DomainMLLE domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16554297
CommentsThe MLLE/PABC domain of rat E3 ubiquitin-protein ligase Ubr5 binds to the N-terminal PAM2 motif of human Ubiquitin carboxyl-terminal hydrolase 10 (USP10)

Record No : 3

Instance ID10612
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQKTLYSFFSP
Bait Uniprot AccessionP13051
Bait Uniprot IdentifierUNG_HUMAN
Bait Gene NameUNG
Sequence Position4-13
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)SPOT assay; Y2H; ELISA
Interaction ID20612
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10393198
CommentsThe PCNA binding PIP box motif in human Uracil-DNA glycosylase (UNG) that mediates interaction with human Proliferating cell nuclear antigen (PCNA/Cyclin)

Record No : 4

Instance ID10621
Regular Expression((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx
Motif InstanceQTTIEDFFGT
Bait Uniprot AccessionP12887
Bait Uniprot IdentifierUNG_YEAST
Bait Gene NameUNG1
Sequence Position21-30
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID20621
Interacting DomainPCNA, C-terminal domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12239216
CommentsThe predicted PCNA binding PIP box motif in Saccharomyces cerevisiae Uracil-DNA glycosylase (UNG1) that may mediate interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30)

Record No : 5

Instance ID10642
Regular Expressionxxx[ST]x[ACVILF]$
Motif InstanceLEDTEL
Bait Uniprot AccessionQ495M9
Bait Uniprot IdentifierUSH1G_HUMAN
Bait Gene NameUSH1G
Sequence Position456-461
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; X-ray crystallography; ITC; Pull down(GST tag)
Interaction ID20642
Interacting DomainPDZ domain
Disease Association(s)Usher's Syndrome
Inhibitor(s)Unknown
Reference(s)20142502, 16283141, 12588794
CommentsC-terminal class 1 PDZ-binding motif in human Usher syndrome type-1G protein (USH1G/SANS) that binds to the first PDZ domain of Harmonin (USH1C)

Record No : 6

Instance ID10788
Regular Expression[LI]xCx[DE]
Motif InstanceLVCPE
Bait Uniprot AccessionQ13107
Bait Uniprot IdentifierUBP4_HUMAN
Bait Gene NameUSP4
Sequence Position459-463
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP
Interaction ID20788
Interacting DomainB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11571651
CommentsThe Rb-binding LxCxE motif in the Human UNP/USP4, a ubiquitin-specific protease, that mediates binding to the human retinoblastoma protein (RB)

Record No : 7

Instance ID10796
Regular Expression[LI]xCx[DE]
Motif InstanceLACSD
Bait Uniprot AccessionP06726
Bait Uniprot IdentifierPP71_HCMVA
Bait Gene NameUL82
Sequence Position216-220
Critical ResiduesP3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP; Western blot; Pull down; Mutation analysis
Interaction ID20796
Interacting DomainB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12612064
CommentsThe Rb-binding LxCxE motif in the Human cytomegalovirus pp71 (UL82) that mediates binding to the human retinoblastoma protein (RB) and induces DNA synthesis in quiescent cells

Record No : 8

Instance ID10801
Regular Expression[LI]xCx[DE]
Motif InstanceLRCRE
Bait Uniprot AccessionP16788
Bait Uniprot IdentifierUL97_HCMVA
Bait Gene NameUL97
Sequence Position149-153
Critical ResiduesP3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20801
Interacting DomainB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18321963
CommentsThe Rb-binding LxCxE motif (149-153) in the Human cytomegalovirus UL97 kinase that mediates binding to the human retinoblastoma protein (RB)

Record No : 9

Instance ID10802
Regular Expression[LI]xCx[DE]
Motif InstanceLACID
Bait Uniprot AccessionP16788
Bait Uniprot IdentifierUL97_HCMVA
Bait Gene NameUL97
Sequence Position426-430
Critical ResiduesP3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20802
Interacting DomainB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18321963
CommentsThe Rb-binding LxCxE motif (426-430) in the Human cytomegalovirus UL97 kinase that mediates binding to the human retinoblastoma protein (RB)

Record No : 10

Instance ID10820
Regular Expression[LIVMP]x{0,2}(T)Pxx([ST])
Motif InstancePGTPPSS
Bait Uniprot AccessionP13051
Bait Uniprot IdentifierUNG_HUMAN
Bait Gene NameUNG
Sequence Position58-64
Critical ResiduesP3
Motif PTM(s)Phosphorylation at Thr-P3
Secondary StructureDisordered
Experimental Method(s)Mass spectrometry; Mutation analysis
Interaction ID20820
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18079698
CommentsThe TPxxS phospho-dependent degron in Human Uracil-DNA glycosylase (UNG) that binds the F box protein FBW7 (also called FBXW7, hCdc4 or hSel10) of the SCF complex via WD40 beta propeller for subsequent ubiquitin-mediated degradation

Record No : 11

Instance ID10911
Regular ExpressionPxxDY
Motif InstancePPVDY
Bait Uniprot AccessionQ92738
Bait Uniprot IdentifierUS6NL_HUMAN
Bait Gene NameUSP6NL
Sequence Position725-729
Critical ResiduesP1; P4; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Alanine scanning; Far-western blotting; ELISA; Pull down(GST tag)
Interaction ID20911
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10508163
CommentsThe SH3 domain of human Epidermal growth factor receptor kinase substrate 8 (EPS8) binds to the PXXDY consensus motif found in human USP6 N-terminal-like protein (USP6NL) or RN-tre

Record No : 12

Instance ID10929
Regular Expression[FA]x[LA][LV][LVI]xx[AM]
Motif InstanceAAAVLSNM
Bait Uniprot AccessionP39001
Bait Uniprot IdentifierUME6_YEAST
Bait Gene NameUME6
Sequence Position523-530
Critical ResiduesP5; P6; P8
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Mutation analysis
Interaction ID20929
Interacting DomainPAH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11238941
CommentsThe DNA-binding Transcriptional regulatory protein Ume6 of Saccharomyces cerevisiae is required for both repression and activation of meiosis-specific genes, through interaction with the yeast Sin3 corepressor

Record No : 13

Instance ID10962
Regular Expression[ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10}
Motif InstanceIVISDSEEE
Bait Uniprot AccessionP19893
Bait Uniprot IdentifierVIE2_HCMVA
Bait Gene NameUL122
Sequence Position200-208
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureExtended conformation
Experimental Method(s)Y2H; Mutation analysis
Interaction ID20962
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19812159
CommentsThe SUMO-interacting motif (SIM) of major transactivator protein IE2p86 (UL122) of human cytomegalovirus (HCMV) that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1)

Record No : 14

Instance ID10963
Regular Expression[ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10}
Motif InstanceIVISDSEEE
Bait Uniprot AccessionQ6SWV3
Bait Uniprot IdentifierQ6SWV3_HCMV
Bait Gene NameUL122
Sequence Position200-208
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureExtended conformation
Experimental Method(s)Pull down; Alanine scanning
Interaction ID20963
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)20519406
CommentsThe 86-kDa immediate-early 2 (IE2) protein of human cytomegalovirus (HCMV) physically binds to human Small ubiquitin-related modifier 1 (SUMO1) through a SUMO-interacting motif (SIM)

Record No : 15

Instance ID10968
Regular Expression[ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10}
Motif InstanceVLIVDSDEEDSS
Bait Uniprot AccessionQ9UBT2
Bait Uniprot IdentifierSAE2_HUMAN
Bait Gene NameUBA2
Sequence Position587-598
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureExtended conformation
Experimental Method(s)Y2H; NMR
Interaction ID20968
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10961991, 15388847
CommentsThe SUMO-interacting motif (SIM) of human SUMO-activating enzyme subunit 2 (SAE2/UBA2) that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1)

Record No : 16

Instance ID10975
Regular Expression[ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10}
Motif InstanceIILSDEDES
Bait Uniprot AccessionQ08562
Bait Uniprot IdentifierULS1_YEAST
Bait Gene NameULS1
Sequence Position372-380
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureExtended conformation
Experimental Method(s)Y2H
Interaction ID20975
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15590687
CommentsThe potential SUMO-binding motif in ATP-dependent helicase Ris1 of Saccharomyces cerevisiae that mediates interactions with Ubiquitin-like protein Smt3 in Saccharomyces cerevisiae

Record No : 17

Instance ID10979
Regular Expression[ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10}
Motif InstanceVIDLT
Bait Uniprot AccessionQ9UHP3
Bait Uniprot IdentifierUBP25_HUMAN
Bait Gene NameUSP25
Sequence Position91-95
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureExtended conformation
Experimental Method(s)Pull down(His tag); Mutation analysis
Interaction ID20979
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18538659
CommentsThe SUMO-interacting motif (SIM) of human Ubiquitin Specific Protease 25 (USP25) that mediates interactions with human Small ubiquitin-related modifier 3 (SUMO3)

Record No : 18

Instance ID11031
Regular ExpressionxxPxExx[FYWHDE]x
Motif InstanceNTPVEDDEM
Bait Uniprot AccessionP10221
Bait Uniprot IdentifierUL37_HHV11
Bait Gene NameUL37
Sequence Position1097-1105
Critical ResiduesP5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Co-IP; Mutation analysis
Interaction ID21031
Interacting DomainMATH domain
Disease Association(s)Herpes simplex virus (HSV) infection
Inhibitor(s)Unknown
Reference(s)18682563
CommentsHerpesvirus Capsid assembly protein UL37 contains a TRAF6 binding site that is required for interaction with human TNF receptor-associated factor 6 (TRAF6) and activation of NF-kappaB

Record No : 19

Instance ID11055
Regular ExpressionPPxY
Motif InstancePPPY
Bait Uniprot AccessionP28282
Bait Uniprot IdentifierUL56_HHV2H
Bait Gene NameUL56
Sequence Position23-26
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Classical fluorescence spectroscopy; Co-IP; Western blot; Y2H; Mutation analysis
Interaction ID21055
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18353951
CommentsThe PY motif (23-26) of the UL56 protein of Herpes simplex virus type 2 that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4 and thereby increased ubiquitinated NEDD4, which was actively degraded in HSV-2 infected cells

Record No : 20

Instance ID11066
Regular ExpressionPPxY
Motif InstancePPPY
Bait Uniprot AccessionP28282
Bait Uniprot IdentifierUL56_HHV2H
Bait Gene NameUL56
Sequence Position49-52
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Classical fluorescence spectroscopy; Co-IP; Western blot; Y2H
Interaction ID21066
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18353951
CommentsThe PY motif (49-52) of the UL56 protein of Herpes simplex virus type 2 that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4 and thereby increased ubiquitinated NEDD4, which was actively degraded in HSV-2 infected cells

Record No : 21

Instance ID11281
Regular Expression[KR]xTQTx
Motif InstanceKSTQTF
Bait Uniprot AccessionL0N469
Bait Uniprot IdentifierL0N469_HHV1
Bait Gene NameUL9
Sequence Position746-751
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Peptide binding assay
Interaction ID21281
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12782328
CommentsThe LC8 dynein light chain binding motif in DNA replication origin-binding helicase UL9 of Herpes simplex virus that binds to the rat 8 kDa Dynein light chain 1 (Dynll1)

Record No : 22

Instance ID11282
Regular Expression[KR]xTQTx
Motif InstanceRSTQTG
Bait Uniprot AccessionQ77Y85
Bait Uniprot IdentifierQ77Y85_9BETA
Bait Gene NameU19
Sequence Position231-236
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Peptide binding assay
Interaction ID21282
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12782328
CommentsThe LC8 dynein light chain binding motif in Human herpesvirus 7 protein U19 that binds to the rat 8 kDa Dynein light chain 1 (Dynll1)

Record No : 23

Instance ID11283
Regular Expression[KR]xTQTx
Motif InstanceRSTQTG
Bait Uniprot AccessionQ69501
Bait Uniprot IdentifierQ69501_HHV7J
Bait Gene NameU19
Sequence Position231-236
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Peptide binding assay
Interaction ID21283
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12782328
CommentsThe LC8 dynein light chain binding motif in Human herpesvirus 7 (strain JI) U19 protein that binds to the rat 8 kDa Dynein light chain 1 (Dynll1)

Record No : 24

Instance ID11636
Regular ExpressionL[EQ]E[FL]LG[DE]
Motif InstanceLQELLGE
Bait Uniprot AccessionQ05086
Bait Uniprot IdentifierUBE3A_HUMAN
Bait Gene NameUBE3A
Sequence Position409-415
Critical ResiduesP1; P4; P5
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)NMR; Mutational analysis; Pull down(GST tag)
Interaction ID21636
Interacting DomainUnknown
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)8393140, 9472622, 11170455
CommentsConsensus E6-binding sequence in E6AP ubiquitin-protein ligase (UBE3A) for binding to E6 oncoprotein of Human papillomavirus type 16

Record No : 25

Instance ID11637
Regular ExpressionL[EQ]E[FL]LG[DE]
Motif InstanceLQELLGE
Bait Uniprot AccessionQ05086
Bait Uniprot IdentifierUBE3A_HUMAN
Bait Gene NameUBE3A
Sequence Position409-415
Critical ResiduesP1; P4; P5
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Site-directed mutagenesis
Interaction ID21637
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11170455
CommentsConsensus E6-binding sequence in E6AP ubiquitin-protein ligase (UBE3A) for binding to E6 oncoprotein of Bovine Papillomavirus Type 1

Record No : 26

Instance ID11917
Regular Expression[FY]PWM[KR]
Motif InstanceYPWMA
Bait Uniprot AccessionP83949
Bait Uniprot IdentifierUBX_DROME
Bait Gene NameUbx
Sequence Position240-244
Critical ResiduesP3
Motif PTM(s)Unknown
Secondary StructureType I reverse turn
Experimental Method(s)X-ray crystallography
Interaction ID21917
Interacting DomainHomeodomain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10067897
CommentsThe highly conserved pentapeptide motif in Drosophila homeotic protein Ultrabithorax that forms a reverse turn and inserts into a hydrophobic pocket on the Drosophila Homeobox protein Extradenticle homeodomain surface to form a cooperative heterodimer and gain affinity and specificity

Record No : 27

Instance ID11964
Regular ExpressionPxxxRxxKP
Motif InstancePQVDRTKKP
Bait Uniprot AccessionQ80U87
Bait Uniprot IdentifierUBP8_MOUSE
Bait Gene NameUsp8
Sequence Position405-413
Critical ResiduesP5; P8
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)SPOT Analysis
Interaction ID21964
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12176364
CommentsThe high-affinity atypical R-X-X-K binding motif 1 (405-413) in mouse Ubiquitin isopeptidase Y for binding the Gads SH3 Domain

Record No : 28

Instance ID11965
Regular ExpressionPxxxRxxKP
Motif InstancePMVNRENKP
Bait Uniprot AccessionQ80U87
Bait Uniprot IdentifierUBP8_MOUSE
Bait Gene NameUsp8
Sequence Position700-708
Critical ResiduesP5; P8
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)SPOT Analysis
Interaction ID21965
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12176364
CommentsThe high-affinity atypical R-X-X-K binding motif 2 (700-708) in mouse Ubiquitin isopeptidase Y for binding the Gads SH3 Domain



© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)