Total : 28 Records
Record No : 1 |
Instance ID | 10599 | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | Motif Instance | STLNPQAPEFILG | Bait Uniprot Accession | Q14694 | Bait Uniprot Identifier | UBP10_HUMAN | Bait Gene Name | USP10 | Sequence Position | 81-93 | Critical Residues | Unknown | Motif PTM(s) | Unknown | Secondary Structure | Unknown | Experimental Method(s) | SPR | Interaction ID | 20599 | Interacting Domain | MLLE domain | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 16554297 | Comments | The MLLE/PABC domain of human Polyadenylate-binding protein 1 (PABP1/PABPC1/PABPC2) binds to the N-terminal PAM2 motif of human Ubiquitin carboxyl-terminal hydrolase 10 (USP10) |
Record No : 2 |
Instance ID | 10600 | Regular Expression | xx[LFP][NS][PIVTAFL]xAxx(([FY]x[PYLF])|(Wxx))x | Motif Instance | STLNPQAPEFILG | Bait Uniprot Accession | Q14694 | Bait Uniprot Identifier | UBP10_HUMAN | Bait Gene Name | USP10 | Sequence Position | 81-93 | Critical Residues | Unknown | Motif PTM(s) | Unknown | Secondary Structure | Unknown | Experimental Method(s) | ITC | Interaction ID | 20600 | Interacting Domain | MLLE domain | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 16554297 | Comments | The MLLE/PABC domain of rat E3 ubiquitin-protein ligase Ubr5 binds to the N-terminal PAM2 motif of human Ubiquitin carboxyl-terminal hydrolase 10 (USP10) |
Record No : 3 |
Instance ID | 10612 | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | Motif Instance | QKTLYSFFSP | Bait Uniprot Accession | P13051 | Bait Uniprot Identifier | UNG_HUMAN | Bait Gene Name | UNG | Sequence Position | 4-13 | Critical Residues | Unknown | Motif PTM(s) | Unknown | Secondary Structure | Alpha helix | Experimental Method(s) | SPOT assay; Y2H; ELISA | Interaction ID | 20612 | Interacting Domain | PCNA, C-terminal domain | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 10393198 | Comments | The PCNA binding PIP box motif in human Uracil-DNA glycosylase (UNG) that mediates interaction with human Proliferating cell nuclear antigen (PCNA/Cyclin) |
Record No : 4 |
Instance ID | 10621 | Regular Expression | ((^x{0,3})|(Q))x[^FHWY][ILM][^P][^FHILVWYP][HFM][FMY]xx | Motif Instance | QTTIEDFFGT | Bait Uniprot Accession | P12887 | Bait Uniprot Identifier | UNG_YEAST | Bait Gene Name | UNG1 | Sequence Position | 21-30 | Critical Residues | Unknown | Motif PTM(s) | Unknown | Secondary Structure | Unknown | Experimental Method(s) | Sequence based prediction | Interaction ID | 20621 | Interacting Domain | PCNA, C-terminal domain | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 12239216 | Comments | The predicted PCNA binding PIP box motif in Saccharomyces cerevisiae Uracil-DNA glycosylase (UNG1) that may mediate interactions with the yeast replication clamp proliferating cell nuclear antigen (PCNA/POL30) |
Record No : 5 |
Instance ID | 10642 | Regular Expression | xxx[ST]x[ACVILF]$ | Motif Instance | LEDTEL | Bait Uniprot Accession | Q495M9 | Bait Uniprot Identifier | USH1G_HUMAN | Bait Gene Name | USH1G | Sequence Position | 456-461 | Critical Residues | Unknown | Motif PTM(s) | Unknown | Secondary Structure | Disordered | Experimental Method(s) | Mutation analysis; X-ray crystallography; ITC; Pull down(GST tag) | Interaction ID | 20642 | Interacting Domain | PDZ domain | Disease Association(s) | Usher's Syndrome | Inhibitor(s) | Unknown | Reference(s) | 20142502, 16283141, 12588794 | Comments | C-terminal class 1 PDZ-binding motif in human Usher syndrome type-1G protein (USH1G/SANS) that binds to the first PDZ domain of Harmonin (USH1C) |
Record No : 6 |
Instance ID | 10788 | Regular Expression | [LI]xCx[DE] | Motif Instance | LVCPE | Bait Uniprot Accession | Q13107 | Bait Uniprot Identifier | UBP4_HUMAN | Bait Gene Name | USP4 | Sequence Position | 459-463 | Critical Residues | Unknown | Motif PTM(s) | Unknown | Secondary Structure | Unknown | Experimental Method(s) | Co-IP | Interaction ID | 20788 | Interacting Domain | B domain | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 11571651 | Comments | The Rb-binding LxCxE motif in the Human UNP/USP4, a ubiquitin-specific protease, that mediates binding to the human retinoblastoma protein (RB) |
Record No : 7 |
Instance ID | 10796 | Regular Expression | [LI]xCx[DE] | Motif Instance | LACSD | Bait Uniprot Accession | P06726 | Bait Uniprot Identifier | PP71_HCMVA | Bait Gene Name | UL82 | Sequence Position | 216-220 | Critical Residues | P3 | Motif PTM(s) | Unknown | Secondary Structure | Unknown | Experimental Method(s) | Co-IP; Western blot; Pull down; Mutation analysis | Interaction ID | 20796 | Interacting Domain | B domain | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 12612064 | Comments | The Rb-binding LxCxE motif in the Human cytomegalovirus pp71 (UL82) that mediates binding to the human retinoblastoma protein (RB) and induces DNA synthesis in quiescent cells |
Record No : 8 |
Instance ID | 10801 | Regular Expression | [LI]xCx[DE] | Motif Instance | LRCRE | Bait Uniprot Accession | P16788 | Bait Uniprot Identifier | UL97_HCMVA | Bait Gene Name | UL97 | Sequence Position | 149-153 | Critical Residues | P3 | Motif PTM(s) | Unknown | Secondary Structure | Unknown | Experimental Method(s) | Mutation analysis | Interaction ID | 20801 | Interacting Domain | B domain | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 18321963 | Comments | The Rb-binding LxCxE motif (149-153) in the Human cytomegalovirus UL97 kinase that mediates binding to the human retinoblastoma protein (RB) |
Record No : 9 |
Instance ID | 10802 | Regular Expression | [LI]xCx[DE] | Motif Instance | LACID | Bait Uniprot Accession | P16788 | Bait Uniprot Identifier | UL97_HCMVA | Bait Gene Name | UL97 | Sequence Position | 426-430 | Critical Residues | P3 | Motif PTM(s) | Unknown | Secondary Structure | Unknown | Experimental Method(s) | Mutation analysis | Interaction ID | 20802 | Interacting Domain | B domain | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 18321963 | Comments | The Rb-binding LxCxE motif (426-430) in the Human cytomegalovirus UL97 kinase that mediates binding to the human retinoblastoma protein (RB) |
Record No : 10 |
Instance ID | 10820 | Regular Expression | [LIVMP]x{0,2}(T)Pxx([ST]) | Motif Instance | PGTPPSS | Bait Uniprot Accession | P13051 | Bait Uniprot Identifier | UNG_HUMAN | Bait Gene Name | UNG | Sequence Position | 58-64 | Critical Residues | P3 | Motif PTM(s) | Phosphorylation at Thr-P3 | Secondary Structure | Disordered | Experimental Method(s) | Mass spectrometry; Mutation analysis | Interaction ID | 20820 | Interacting Domain | WD40 repeat domain | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 18079698 | Comments | The TPxxS phospho-dependent degron in Human Uracil-DNA glycosylase (UNG) that binds the F box protein FBW7 (also called FBXW7, hCdc4 or hSel10) of the SCF complex via WD40 beta propeller for subsequent ubiquitin-mediated degradation |
Record No : 11 |
Instance ID | 10911 | Regular Expression | PxxDY | Motif Instance | PPVDY | Bait Uniprot Accession | Q92738 | Bait Uniprot Identifier | US6NL_HUMAN | Bait Gene Name | USP6NL | Sequence Position | 725-729 | Critical Residues | P1; P4; P5 | Motif PTM(s) | Unknown | Secondary Structure | Unknown | Experimental Method(s) | Alanine scanning; Far-western blotting; ELISA; Pull down(GST tag) | Interaction ID | 20911 | Interacting Domain | SH3 domain | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 10508163 | Comments | The SH3 domain of human Epidermal growth factor receptor kinase substrate 8 (EPS8) binds to the PXXDY consensus motif found in human USP6 N-terminal-like protein (USP6NL) or RN-tre |
Record No : 12 |
Instance ID | 10929 | Regular Expression | [FA]x[LA][LV][LVI]xx[AM] | Motif Instance | AAAVLSNM | Bait Uniprot Accession | P39001 | Bait Uniprot Identifier | UME6_YEAST | Bait Gene Name | UME6 | Sequence Position | 523-530 | Critical Residues | P5; P6; P8 | Motif PTM(s) | Unknown | Secondary Structure | Alpha helix | Experimental Method(s) | Mutation analysis | Interaction ID | 20929 | Interacting Domain | PAH2 domain | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 11238941 | Comments | The DNA-binding Transcriptional regulatory protein Ume6 of Saccharomyces cerevisiae is required for both repression and activation of meiosis-specific genes, through interaction with the yeast Sin3 corepressor |
Record No : 13 |
Instance ID | 10962 | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | Motif Instance | IVISDSEEE | Bait Uniprot Accession | P19893 | Bait Uniprot Identifier | VIE2_HCMVA | Bait Gene Name | UL122 | Sequence Position | 200-208 | Critical Residues | Unknown | Motif PTM(s) | Unknown | Secondary Structure | Extended conformation | Experimental Method(s) | Y2H; Mutation analysis | Interaction ID | 20962 | Interacting Domain | Unknown | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 19812159 | Comments | The SUMO-interacting motif (SIM) of major transactivator protein IE2p86 (UL122) of human cytomegalovirus (HCMV) that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1) |
Record No : 14 |
Instance ID | 10963 | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | Motif Instance | IVISDSEEE | Bait Uniprot Accession | Q6SWV3 | Bait Uniprot Identifier | Q6SWV3_HCMV | Bait Gene Name | UL122 | Sequence Position | 200-208 | Critical Residues | Unknown | Motif PTM(s) | Unknown | Secondary Structure | Extended conformation | Experimental Method(s) | Pull down; Alanine scanning | Interaction ID | 20963 | Interacting Domain | Unknown | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 20519406 | Comments | The 86-kDa immediate-early 2 (IE2) protein of human cytomegalovirus (HCMV) physically binds to human Small ubiquitin-related modifier 1 (SUMO1) through a SUMO-interacting motif (SIM) |
Record No : 15 |
Instance ID | 10968 | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | Motif Instance | VLIVDSDEEDSS | Bait Uniprot Accession | Q9UBT2 | Bait Uniprot Identifier | SAE2_HUMAN | Bait Gene Name | UBA2 | Sequence Position | 587-598 | Critical Residues | Unknown | Motif PTM(s) | Unknown | Secondary Structure | Extended conformation | Experimental Method(s) | Y2H; NMR | Interaction ID | 20968 | Interacting Domain | Unknown | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 10961991, 15388847 | Comments | The SUMO-interacting motif (SIM) of human SUMO-activating enzyme subunit 2 (SAE2/UBA2) that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1) |
Record No : 16 |
Instance ID | 10975 | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | Motif Instance | IILSDEDES | Bait Uniprot Accession | Q08562 | Bait Uniprot Identifier | ULS1_YEAST | Bait Gene Name | ULS1 | Sequence Position | 372-380 | Critical Residues | Unknown | Motif PTM(s) | Unknown | Secondary Structure | Extended conformation | Experimental Method(s) | Y2H | Interaction ID | 20975 | Interacting Domain | Unknown | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 15590687 | Comments | The potential SUMO-binding motif in ATP-dependent helicase Ris1 of Saccharomyces cerevisiae that mediates interactions with Ubiquitin-like protein Smt3 in Saccharomyces cerevisiae |
Record No : 17 |
Instance ID | 10979 | Regular Expression | [ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10} | Motif Instance | VIDLT | Bait Uniprot Accession | Q9UHP3 | Bait Uniprot Identifier | UBP25_HUMAN | Bait Gene Name | USP25 | Sequence Position | 91-95 | Critical Residues | Unknown | Motif PTM(s) | Unknown | Secondary Structure | Extended conformation | Experimental Method(s) | Pull down(His tag); Mutation analysis | Interaction ID | 20979 | Interacting Domain | Unknown | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 18538659 | Comments | The SUMO-interacting motif (SIM) of human Ubiquitin Specific Protease 25 (USP25) that mediates interactions with human Small ubiquitin-related modifier 3 (SUMO3) |
Record No : 18 |
Instance ID | 11031 | Regular Expression | xxPxExx[FYWHDE]x | Motif Instance | NTPVEDDEM | Bait Uniprot Accession | P10221 | Bait Uniprot Identifier | UL37_HHV11 | Bait Gene Name | UL37 | Sequence Position | 1097-1105 | Critical Residues | P5 | Motif PTM(s) | Unknown | Secondary Structure | Unknown | Experimental Method(s) | Pull down; Co-IP; Mutation analysis | Interaction ID | 21031 | Interacting Domain | MATH domain | Disease Association(s) | Herpes simplex virus (HSV) infection | Inhibitor(s) | Unknown | Reference(s) | 18682563 | Comments | Herpesvirus Capsid assembly protein UL37 contains a TRAF6 binding site that is required for interaction with human TNF receptor-associated factor 6 (TRAF6) and activation of NF-kappaB |
Record No : 19 |
Instance ID | 11055 | Regular Expression | PPxY | Motif Instance | PPPY | Bait Uniprot Accession | P28282 | Bait Uniprot Identifier | UL56_HHV2H | Bait Gene Name | UL56 | Sequence Position | 23-26 | Critical Residues | Unknown | Motif PTM(s) | Unknown | Secondary Structure | Unknown | Experimental Method(s) | Classical fluorescence spectroscopy; Co-IP; Western blot; Y2H; Mutation analysis | Interaction ID | 21055 | Interacting Domain | WW domain | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 18353951 | Comments | The PY motif (23-26) of the UL56 protein of Herpes simplex virus type 2 that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4 and thereby increased ubiquitinated NEDD4, which was actively degraded in HSV-2 infected cells |
Record No : 20 |
Instance ID | 11066 | Regular Expression | PPxY | Motif Instance | PPPY | Bait Uniprot Accession | P28282 | Bait Uniprot Identifier | UL56_HHV2H | Bait Gene Name | UL56 | Sequence Position | 49-52 | Critical Residues | Unknown | Motif PTM(s) | Unknown | Secondary Structure | Unknown | Experimental Method(s) | Mutation analysis; Classical fluorescence spectroscopy; Co-IP; Western blot; Y2H | Interaction ID | 21066 | Interacting Domain | WW domain | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 18353951 | Comments | The PY motif (49-52) of the UL56 protein of Herpes simplex virus type 2 that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4 and thereby increased ubiquitinated NEDD4, which was actively degraded in HSV-2 infected cells |
Record No : 21 |
Instance ID | 11281 | Regular Expression | [KR]xTQTx | Motif Instance | KSTQTF | Bait Uniprot Accession | L0N469 | Bait Uniprot Identifier | L0N469_HHV1 | Bait Gene Name | UL9 | Sequence Position | 746-751 | Critical Residues | Unknown | Motif PTM(s) | Unknown | Secondary Structure | Unknown | Experimental Method(s) | Peptide binding assay | Interaction ID | 21281 | Interacting Domain | Unknown | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 12782328 | Comments | The LC8 dynein light chain binding motif in DNA replication origin-binding helicase UL9 of Herpes simplex virus that binds to the rat 8 kDa Dynein light chain 1 (Dynll1) |
Record No : 22 |
Instance ID | 11282 | Regular Expression | [KR]xTQTx | Motif Instance | RSTQTG | Bait Uniprot Accession | Q77Y85 | Bait Uniprot Identifier | Q77Y85_9BETA | Bait Gene Name | U19 | Sequence Position | 231-236 | Critical Residues | Unknown | Motif PTM(s) | Unknown | Secondary Structure | Unknown | Experimental Method(s) | Peptide binding assay | Interaction ID | 21282 | Interacting Domain | Unknown | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 12782328 | Comments | The LC8 dynein light chain binding motif in Human herpesvirus 7 protein U19 that binds to the rat 8 kDa Dynein light chain 1 (Dynll1) |
Record No : 23 |
Instance ID | 11283 | Regular Expression | [KR]xTQTx | Motif Instance | RSTQTG | Bait Uniprot Accession | Q69501 | Bait Uniprot Identifier | Q69501_HHV7J | Bait Gene Name | U19 | Sequence Position | 231-236 | Critical Residues | Unknown | Motif PTM(s) | Unknown | Secondary Structure | Unknown | Experimental Method(s) | Peptide binding assay | Interaction ID | 21283 | Interacting Domain | Unknown | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 12782328 | Comments | The LC8 dynein light chain binding motif in Human herpesvirus 7 (strain JI) U19 protein that binds to the rat 8 kDa Dynein light chain 1 (Dynll1) |
Record No : 24 |
Instance ID | 11636 | Regular Expression | L[EQ]E[FL]LG[DE] | Motif Instance | LQELLGE | Bait Uniprot Accession | Q05086 | Bait Uniprot Identifier | UBE3A_HUMAN | Bait Gene Name | UBE3A | Sequence Position | 409-415 | Critical Residues | P1; P4; P5 | Motif PTM(s) | Unknown | Secondary Structure | Alpha helix | Experimental Method(s) | NMR; Mutational analysis; Pull down(GST tag) | Interaction ID | 21636 | Interacting Domain | Unknown | Disease Association(s) | Cancer | Inhibitor(s) | Unknown | Reference(s) | 8393140, 9472622, 11170455 | Comments | Consensus E6-binding sequence in E6AP ubiquitin-protein ligase (UBE3A) for binding to E6 oncoprotein of Human papillomavirus type 16 |
Record No : 25 |
Instance ID | 11637 | Regular Expression | L[EQ]E[FL]LG[DE] | Motif Instance | LQELLGE | Bait Uniprot Accession | Q05086 | Bait Uniprot Identifier | UBE3A_HUMAN | Bait Gene Name | UBE3A | Sequence Position | 409-415 | Critical Residues | P1; P4; P5 | Motif PTM(s) | Unknown | Secondary Structure | Alpha helix | Experimental Method(s) | Site-directed mutagenesis | Interaction ID | 21637 | Interacting Domain | Unknown | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 11170455 | Comments | Consensus E6-binding sequence in E6AP ubiquitin-protein ligase (UBE3A) for binding to E6 oncoprotein of Bovine Papillomavirus Type 1 |
Record No : 26 |
Instance ID | 11917 | Regular Expression | [FY]PWM[KR] | Motif Instance | YPWMA | Bait Uniprot Accession | P83949 | Bait Uniprot Identifier | UBX_DROME | Bait Gene Name | Ubx | Sequence Position | 240-244 | Critical Residues | P3 | Motif PTM(s) | Unknown | Secondary Structure | Type I reverse turn | Experimental Method(s) | X-ray crystallography | Interaction ID | 21917 | Interacting Domain | Homeodomain | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 10067897 | Comments | The highly conserved pentapeptide motif in Drosophila homeotic protein Ultrabithorax that forms a reverse turn and inserts into a hydrophobic pocket on the Drosophila Homeobox protein Extradenticle homeodomain surface to form a cooperative heterodimer and gain affinity and specificity |
Record No : 27 |
Instance ID | 11964 | Regular Expression | PxxxRxxKP | Motif Instance | PQVDRTKKP | Bait Uniprot Accession | Q80U87 | Bait Uniprot Identifier | UBP8_MOUSE | Bait Gene Name | Usp8 | Sequence Position | 405-413 | Critical Residues | P5; P8 | Motif PTM(s) | Unknown | Secondary Structure | Unknown | Experimental Method(s) | SPOT Analysis | Interaction ID | 21964 | Interacting Domain | SH3 domain | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 12176364 | Comments | The high-affinity atypical R-X-X-K binding motif 1 (405-413) in mouse Ubiquitin isopeptidase Y for binding the Gads SH3 Domain |
Record No : 28 |
Instance ID | 11965 | Regular Expression | PxxxRxxKP | Motif Instance | PMVNRENKP | Bait Uniprot Accession | Q80U87 | Bait Uniprot Identifier | UBP8_MOUSE | Bait Gene Name | Usp8 | Sequence Position | 700-708 | Critical Residues | P5; P8 | Motif PTM(s) | Unknown | Secondary Structure | Unknown | Experimental Method(s) | SPOT Analysis | Interaction ID | 21965 | Interacting Domain | SH3 domain | Disease Association(s) | Unknown | Inhibitor(s) | Unknown | Reference(s) | 12176364 | Comments | The high-affinity atypical R-X-X-K binding motif 2 (700-708) in mouse Ubiquitin isopeptidase Y for binding the Gads SH3 Domain |
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