Total : 36 Records


Record No : 1

Instance ID10263
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLDLS
Bait Uniprot AccessionQ64318
Bait Uniprot IdentifierZEB1_MOUSE
Bait Gene NameZeb1
Sequence Position712-716
Critical ResiduesP3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H
Interaction ID20263
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10567582
CommentsThe PxDLS motif in mouse zinc finger-homeodomain factor Delta EF1 that serve as the site for interaction with mouse CtBP1

Record No : 2

Instance ID10264
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLDLS
Bait Uniprot AccessionQ64318
Bait Uniprot IdentifierZEB1_MOUSE
Bait Gene NameZeb1
Sequence Position712-716
Critical ResiduesP3; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H
Interaction ID20264
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10567582
CommentsThe PxDLS motif in mouse zinc finger-homeodomain factor Delta EF1 that serve as the site for interaction with mouse CtBP2

Record No : 3

Instance ID10275
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLDLS
Bait Uniprot AccessionO60315
Bait Uniprot IdentifierZEB2_HUMAN
Bait Gene NameZEB2
Sequence Position815-819
Critical ResiduesP1; P2; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Alanine scanning
Interaction ID20275
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12714599
CommentsInteraction between human Smad-interacting protein-1 (ZEB2) and the corepressor C-terminal binding protein (CTBP1) through conserved PXDLS-like motif (815-819)

Record No : 4

Instance ID10276
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLNLS
Bait Uniprot AccessionO60315
Bait Uniprot IdentifierZEB2_HUMAN
Bait Gene NameZEB2
Sequence Position785-789
Critical ResiduesP1; P2; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Alanine scanning
Interaction ID20276
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12714599
CommentsInteraction between human Smad-interacting protein-1 (ZEB2) and the corepressor C-terminal binding protein (CTBP1) through conserved PXDLS-like motif (785-789)

Record No : 5

Instance ID10277
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLNLT
Bait Uniprot AccessionO60315
Bait Uniprot IdentifierZEB2_HUMAN
Bait Gene NameZEB2
Sequence Position859-863
Critical ResiduesP1; P2; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Alanine scanning
Interaction ID20277
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12714599
CommentsInteraction between human Smad-interacting protein-1 (ZEB2) and the corepressor C-terminal binding protein (CTBP1) through conserved PXDLS-like motif (859-863)

Record No : 6

Instance ID10280
Regular Expression([P][LVIPME][DENS][LM][VASTRG])|([G][LVIPME][DENS][LM][VASTRG]((K)|(x[KR])))
Motif InstancePLDLS
Bait Uniprot AccessionP28166
Bait Uniprot IdentifierZFH1_DROME
Bait Gene Namezfh1
Sequence Position786-790
Critical ResiduesP1; P2; P3; P4; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Y2H
Interaction ID20280
Interacting DomainD-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10359772
CommentsDrosophila Zinc finger protein 1 (zfh-1), homologue of active transcriptional repressor ZEB, interacts with the corepressor CtBP to repress transcription through the PxDLS motif

Record No : 7

Instance ID10303
Regular Expression[^P]x[KR]xTQT
Motif InstanceLHRSTQT
Bait Uniprot AccessionQ15326
Bait Uniprot IdentifierZMY11_HUMAN
Bait Gene NameZMYND11
Sequence Position411-417
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Y2H; Sequence based prediction
Interaction ID20303
Interacting DomainDynein light chain type 1
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11148209
CommentsDynein (Light Chain) binding KxTQT motif in human Zinc finger MYND domain-containing protein BS69 that binds to DLC-8 (highly conserved 8-kDa light chain of Dynein)

Record No : 8

Instance ID10335
Regular ExpressionxNPFx
Motif InstanceLNPFD
Bait Uniprot AccessionQ9H1K0
Bait Uniprot IdentifierRBNS5_HUMAN
Bait Gene NameZFYVE20
Sequence Position625-629
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Classical fluorescence spectroscopy; Y2H
Interaction ID20335
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15020713
CommentsRabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane through the NPF motif (625-629) of Rabenosyn-5

Record No : 9

Instance ID10340
Regular ExpressionxNPFx
Motif InstanceYNPFE
Bait Uniprot AccessionQ9H1K0
Bait Uniprot IdentifierRBNS5_HUMAN
Bait Gene NameZFYVE20
Sequence Position661-665
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Classical fluorescence spectroscopy; Y2H
Interaction ID20340
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15020713
CommentsRabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane through the NPF motif (661-665) of Rabenosyn-5

Record No : 10

Instance ID10347
Regular ExpressionxNPFx
Motif InstanceGNPFI
Bait Uniprot AccessionQ9H1K0
Bait Uniprot IdentifierRBNS5_HUMAN
Bait Gene NameZFYVE20
Sequence Position676-680
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H
Interaction ID20347
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15020713
CommentsRabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane through the NPF motif (676-680) of Rabenosyn-5

Record No : 11

Instance ID10350
Regular ExpressionxNPFx
Motif InstancePNPFS
Bait Uniprot AccessionQ9H1K0
Bait Uniprot IdentifierRBNS5_HUMAN
Bait Gene NameZFYVE20
Sequence Position687-691
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H
Interaction ID20350
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15020713
CommentsRabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane through the NPF motif (687-691) of Rabenosyn-5

Record No : 12

Instance ID10353
Regular ExpressionxNPFx
Motif InstanceGNPFE
Bait Uniprot AccessionQ9H1K0
Bait Uniprot IdentifierRBNS5_HUMAN
Bait Gene NameZFYVE20
Sequence Position708-712
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H
Interaction ID20353
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15020713
CommentsRabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane through the NPF motif (708-712) of Rabenosyn-5

Record No : 13

Instance ID10356
Regular ExpressionxNPFx
Motif InstanceINPFE
Bait Uniprot AccessionQ9H1K0
Bait Uniprot IdentifierRBNS5_HUMAN
Bait Gene NameZFYVE20
Sequence Position717-721
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Y2H
Interaction ID20356
Interacting DomainEH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15020713
CommentsRabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane through the NPF motif (717-721) of Rabenosyn-5

Record No : 14

Instance ID10423
Regular Expression([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P)
Motif InstanceFPPPP
Bait Uniprot AccessionQ15942
Bait Uniprot IdentifierZYX_HUMAN
Bait Gene NameZYX
Sequence Position93-97
Critical ResiduesP1
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20423
Interacting DomainWH1 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10801818
CommentsProline-rich motif (93-97) within human Zyxin that is required for its interaction with ENAH

Record No : 15

Instance ID10424
Regular Expression([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P)
Motif InstanceFPSPP
Bait Uniprot AccessionQ15942
Bait Uniprot IdentifierZYX_HUMAN
Bait Gene NameZYX
Sequence Position114-118
Critical ResiduesP1
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20424
Interacting DomainWH1 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10801818
CommentsProline-rich motif (114-118) within human Zyxin that is required for its interaction with ENAH

Record No : 16

Instance ID10425
Regular Expression([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P)
Motif InstanceFPPAP
Bait Uniprot AccessionQ15942
Bait Uniprot IdentifierZYX_HUMAN
Bait Gene NameZYX
Sequence Position104-108
Critical ResiduesP1
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20425
Interacting DomainWH1 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10801818
CommentsProline-rich motif (104-108) within human Zyxin that is required for its interaction with ENAH

Record No : 17

Instance ID10426
Regular Expression([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P)
Motif InstanceFPSPP
Bait Uniprot AccessionQ04584
Bait Uniprot IdentifierZYX_CHICK
Bait Gene NameZYX
Sequence Position121-125
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Western blot; Pull down(GST tag)
Interaction ID20426
Interacting DomainWH1 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9693373
CommentsProline-rich motif (121-125) within chicken zyxin that is required for its interaction with ENAH

Record No : 18

Instance ID10427
Regular Expression([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P)
Motif InstanceFPPAP
Bait Uniprot AccessionQ04584
Bait Uniprot IdentifierZYX_CHICK
Bait Gene NameZYX
Sequence Position113-117
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Western blot; Pull down(GST tag)
Interaction ID20427
Interacting DomainWH1 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9693373
CommentsProline-rich motif (113-117) within chicken zyxin that is required for its interaction with ENAH

Record No : 19

Instance ID10428
Regular Expression([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P)
Motif InstanceFPPPP
Bait Uniprot AccessionQ04584
Bait Uniprot IdentifierZYX_CHICK
Bait Gene NameZYX
Sequence Position102-106
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Western blot; Pull down(GST tag)
Interaction ID20428
Interacting DomainWH1 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9693373
CommentsProline-rich motif (102-106) within chicken zyxin that is required for its interaction with ENAH

Record No : 20

Instance ID10440
Regular Expression([FYWL]PxPP)|([FYWL]PP[ALIVTFY]P)
Motif InstanceFPLPP
Bait Uniprot AccessionQ15942
Bait Uniprot IdentifierZYX_HUMAN
Bait Gene NameZYX
Sequence Position71-75
Critical ResiduesP1
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis
Interaction ID20440
Interacting DomainWH1 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10801818
CommentsProline-rich motif (71-75) within human Zyxin that is required for its interaction with ENAH

Record No : 21

Instance ID10980
Regular Expression[ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10}
Motif InstanceIVLSDSE
Bait Uniprot AccessionQ8N3Z6
Bait Uniprot IdentifierZCHC7_HUMAN
Bait Gene NameZCCHC7
Sequence Position75-81
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureExtended conformation
Experimental Method(s)Y2H
Interaction ID20980
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16524884
CommentsThe SUMO-interacting motif (SIM) of the zinc finger-containing human RNA-binding factor ZCCHC7 that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1)

Record No : 22

Instance ID10981
Regular Expression[ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10}
Motif InstanceIIEVSSSEEEEST
Bait Uniprot AccessionQ8N3Z6
Bait Uniprot IdentifierZCHC7_HUMAN
Bait Gene NameZCCHC7
Sequence Position154-166
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureExtended conformation
Experimental Method(s)Y2H
Interaction ID20981
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16524884
CommentsThe SUMO-interacting motif (SIM) of the zinc finger-containing human RNA-binding factor ZCCHC7 that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1)

Record No : 23

Instance ID10982
Regular Expression[ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10}
Motif InstanceIIIDSSDETTES
Bait Uniprot AccessionQ9UKY1
Bait Uniprot IdentifierZHX1_HUMAN
Bait Gene NameZHX1
Sequence Position538-549
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureExtended conformation
Experimental Method(s)Y2H
Interaction ID20982
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16524884
CommentsThe SUMO-interacting motif (SIM) of the human Zinc fingers and homeoboxes protein 1 (ZHX1) that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1)

Record No : 24

Instance ID10983
Regular Expression[ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10}
Motif InstanceIVIDDEED
Bait Uniprot AccessionQ9UJ78
Bait Uniprot IdentifierZMYM5_HUMAN
Bait Gene NameZMYM5
Sequence Position117-124
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureExtended conformation
Experimental Method(s)Y2H
Interaction ID20983
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16524884
CommentsThe SUMO-interacting motif (SIM) of the human Zinc finger MYM-type protein 5 (ZMYM5) that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1)

Record No : 25

Instance ID10984
Regular Expression[ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10}
Motif InstanceIDLVSSDDEE
Bait Uniprot AccessionQ9Y4E5
Bait Uniprot IdentifierZN451_HUMAN
Bait Gene NameZNF451
Sequence Position46-55
Critical ResiduesP3; P4
Motif PTM(s)Unknown
Secondary StructureExtended conformation
Experimental Method(s)Pull down; Mutation analysis
Interaction ID20984
Interacting DomainUnknown
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)18656483
CommentsThe SUMO-interacting motif (SIM) of the human Zinc finger protein 451 (ZNF451) that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1)

Record No : 26

Instance ID10987
Regular Expression[STDE]{1,10}[ILV](x[ILV]|[ILV]|[ILV]x)[ILV]
Motif InstanceDDDDVVFI
Bait Uniprot AccessionQ9UJ78
Bait Uniprot IdentifierZMYM5_HUMAN
Bait Gene NameZMYM5
Sequence Position56-63
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureExtended conformation
Experimental Method(s)Y2H
Interaction ID20987
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16524884
CommentsInverted version of the SUMO-interacting motif (SIM) of the human Zinc finger MYM-type protein 5 (ZMYM5) that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1)

Record No : 27

Instance ID11271
Regular Expression[KR]xTQTx
Motif InstanceKSTQTQ
Bait Uniprot AccessionQ02975
Bait Uniprot IdentifierZ354A_RAT
Bait Gene NameZnf354a
Sequence Position96-101
Critical ResiduesP1; P4; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Peptide binding assay
Interaction ID21271
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11513870
CommentsThe LC8 dynein light chain binding motif in rat Renal transcription factor Kid-1 (Znf354a) that binds to the rat 8 kDa Dynein light chain 1 (Dynll1)

Record No : 28

Instance ID11272
Regular Expression[KR]xTQTx
Motif InstanceKSTQTQ
Bait Uniprot AccessionQ61751
Bait Uniprot IdentifierZ354A_MOUSE
Bait Gene NameZnf354a
Sequence Position95-100
Critical ResiduesP1; P4; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Peptide binding assay
Interaction ID21272
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11513870
CommentsThe LC8 dynein light chain binding motif in mouse Renal transcription factor Kid-1 (Znf354a) that binds to the rat 8 kDa Dynein light chain 1 (Dynll1)

Record No : 29

Instance ID11273
Regular Expression[KR]xTQTx
Motif InstanceKSTQTQ
Bait Uniprot AccessionO60765
Bait Uniprot IdentifierZ354A_HUMAN
Bait Gene NameZNF354A
Sequence Position95-100
Critical ResiduesP1; P4; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Peptide binding assay
Interaction ID21273
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11513870
CommentsThe LC8 dynein light chain binding motif in human Zinc finger protein 354A (ZNF354A)/ Transcription factor 17 (TCF17)/ Zinc finger protein EZNF that binds to the rat 8 kDa Dynein light chain 1 (Dynll1)

Record No : 30

Instance ID11324
Regular Expression[DS]Kx[TVI]Q[TV][DE]
Motif InstanceHRSTQTT
Bait Uniprot AccessionQ15326
Bait Uniprot IdentifierZMY11_HUMAN
Bait Gene NameZMYND11
Sequence Position452-458
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Peptide binding assay
Interaction ID21324
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)21533121
CommentsThe LC8 dynein light chain binding motif in human Zinc finger MYND domain-containing protein 11 (ZMYND11) that interacts with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8)

Record No : 31

Instance ID11325
Regular Expression[DS]Kx[TVI]Q[TV][DE]
Motif InstanceHRSTQTT
Bait Uniprot AccessionQ15326
Bait Uniprot IdentifierZMY11_HUMAN
Bait Gene NameZMYND11
Sequence Position452-458
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Peptide binding assay
Interaction ID21325
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)21533121
CommentsThe LC8 dynein light chain binding motif in human Zinc finger MYND domain-containing protein 11 (ZMYND11) that interacts with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2)

Record No : 32

Instance ID11326
Regular Expression[DS]Kx[TVI]Q[TV][DE]
Motif InstanceTKSTQTQ
Bait Uniprot AccessionQ02975
Bait Uniprot IdentifierZ354A_RAT
Bait Gene NameZnf354a
Sequence Position95-101
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Peptide binding assay
Interaction ID21326
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)21533121
CommentsThe LC8 dynein light chain binding motif in rat Renal transcription factor Kid-1/ Zinc finger protein 354A (Znf354a) that interacts with the human 8 kDa Dynein light chain 1 (DYNLL1/DLC8)

Record No : 33

Instance ID11327
Regular Expression[DS]Kx[TVI]Q[TV][DE]
Motif InstanceTKSTQTQ
Bait Uniprot AccessionQ02975
Bait Uniprot IdentifierZ354A_RAT
Bait Gene NameZnf354a
Sequence Position95-101
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Peptide binding assay
Interaction ID21327
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)21533121
CommentsThe LC8 dynein light chain binding motif in rat Renal transcription factor Kid-1/ Zinc finger protein 354A (Znf354a) that interacts with the human 8 kDa Dynein light chain 2 (DYNLL2/DLC2)

Record No : 34

Instance ID11856
Regular Expression[ND]xY[ST]xxP
Motif InstanceDGYTPEP
Bait Uniprot AccessionP43403
Bait Uniprot IdentifierZAP70_HUMAN
Bait Gene NameZAP70
Sequence Position290-296
Critical ResiduesP1; P3; P7
Motif PTM(s)Phosphorylation at Tyr-P3
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; Site-directed mutagenesis
Interaction ID21856
Interacting DomainTKB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9407100, 15737992, 10078535
CommentsConsensus sequence for phosphotyrosine recognition by the Cbl TKB domain in Tyrosine-protein kinase ZAP-70 that has been demonstrated to be an important in vivo negative regulatory site for ZAP-70 by Cbl

Record No : 35

Instance ID11981
Regular ExpressionAPKPKVNPF
Motif InstanceAPKPKVNPF
Bait Uniprot AccessionQ15942
Bait Uniprot IdentifierZYX_HUMAN
Bait Gene NameZYX
Sequence Position31-39
Critical ResiduesP1; P3; P9
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Site-directed mutagenesis
Interaction ID21981
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15004028
CommentsLinear binding motif in human Zyxin that is crucial for its interaction with the SH3 Domain of LIM-nebulette (LNEBL) and thus may play an important role in the organization of focal adhesions

Record No : 36

Instance ID11982
Regular ExpressionAPKPKVNPF
Motif InstanceAPKPKVNPF
Bait Uniprot AccessionQ15942
Bait Uniprot IdentifierZYX_HUMAN
Bait Gene NameZYX
Sequence Position31-39
Critical ResiduesP1; P3; P9
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Site-directed mutagenesis
Interaction ID21982
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15004028
CommentsLinear binding motif in human Zyxin that is crucial for its interaction with the SH3 Domain of LASP1 and thus may play an important role in the organization of focal adhesions



© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)