Record No:1
| ACCESS NO | D108128 |
| GENE_NAME | RUNX3 |
| DESCRIPTION | RUNX family transcription factor 3 |
| ALIASES | AML2, CBFA3, PEBP2aC. |
| NCBI_ENTREZ_NO | 864 |
| UNIPROT_ACCESS_NO | Q13761 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | CD4 T cells |
| TECHNIQUES | qRT-PCR, Western Blotting |
| OMICS | Genomics, Proteomics |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | RUNX3 expression was significantly decreased in CD4 T cells from asthmatic patients as compared to healthy controls. RUNX3 may be used as biomarker or target in the diagnosis or therapy of asthma. |
| REFERENCE | 27902892 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | RNA polymerase II regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity(RNA polymerase II-specific), DNA binding, DNA-binding transcription factor activity, protein binding, ATP binding. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, chondrocyte differentiation, regulation of DNA-templated transcription, transcription by RNA polymerase II, protein phosphorylation, hemopoiesis, neuron differentiation, negative regulation of CD4-positive (alpha-beta T cell differentiation), positive regulation of CD8-positive (alpha-beta T cell differentiation), negative regulation of cell cycle, positive regulation of DNA-templated transcription, peripheral nervous system neuron development, negative regulation of epithelial cell proliferation, response to transforming growth factor beta. |
| BIOGRID_INTERACTION_ID | 107312 |
| SNP_ID | 300779 |
| DRUG_ID | - |
| STRUCTURE_ID | 204182 |
| MONOCLONAL_ANTIBODY | Anti-RUNX3 antibody for Human, Mouse; Anti-RUNX1 / AML1+RUNX3+RUNX2 antibody for Human, Mouse, Rat. |