Record No:1
| ACCESS NO | D109374 |
| GENE_NAME | REL |
| DESCRIPTION | REL proto-oncogene, NF-kB subunit |
| ALIASES | C-Rel. |
| NCBI_ENTREZ_NO | 5966 |
| UNIPROT_ACCESS_NO | Q04864 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | REL was decreased in asthmatic patients as compared to allergic rhinitis patients and healthy controls. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding, DNA-binding transcription factor activity (RNA polymerase II-specific), DNA-binding transcription activator activity (RNA polymerase II-specific), DNA binding, chromatin binding, DNA-binding transcription factor activity, protein binding, sequence-specific DNA binding. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, inflammatory response, I-kappaB kinase/NF-kappaB signaling, negative regulation of gene expression, negative regulation of interferon-beta production, response to cytokine, NIK/NF-kappaB signaling, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, negative regulation of neuron death. |
| BIOGRID_INTERACTION_ID | 111898 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 205870 |
| MONOCLONAL_ANTIBODY | Anti-c-Rel antibody for Human. |