Record No:1
| ACCESS NO | D109702 |
| GENE_NAME | IRS2 |
| DESCRIPTION | Insulin receptor substrate 2 |
| ALIASES | IRS-2. |
| NCBI_ENTREZ_NO | 8660 |
| UNIPROT_ACCESS_NO | Q9Y4H2 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | IRS2 was significantly decreased in asthmatics as compared to allergic rhinitis patients. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Insulin receptor binding, protein binding, protein kinase binding, protein phosphatase binding, protein domain specific binding, phosphatidylinositol 3-kinase binding, 14-3-3 protein binding. |
| GO_BIOLOGICAL_PROCESS | MAPK cascade, positive regulation of mesenchymal cell proliferation, negative regulation of B cell apoptotic process, glucose metabolic process, signal transduction, axon guidance, brain development, positive regulation of cell proliferation, insulin receptor signaling pathway, response to glucose, negative regulation of plasma membrane long-chain fatty acid transport, positive regulation of glucose metabolic process, positive regulation of phosphatidylinositol 3-kinase signaling, regulation of lipid metabolic process, positive regulation of cell migration, mammary gland development, positive regulation of B cell proliferation, positive regulation of fatty acid beta-oxidation, positive regulation of insulin secretion, cellular response to insulin stimulus, negative regulation of kinase activity, interleukin-7-mediated signaling pathway, positive regulation of glycogen biosynthetic process, positive regulation of glucose import, positive regulation of Ras protein signal transduction, phosphatidylinositol-mediated signaling, positive regulation of protein kinase B signaling, lipid homeostasis, cellular response to glucose stimulus, cellular response to peptide. |
| BIOGRID_INTERACTION_ID | 114209 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 205405 |
| MONOCLONAL_ANTIBODY | Anti-IRS2 antibody ffor Human, Mouse, Rat; Anti-IRS1 + IRS2 (phospho S1101) antibody for Human. |