DRAGdb: Drug Resistance Associated Genes
Number of mutation entries of gyrA in ESKAPE bacteria is 41
PROVEAN score threshold is -2.5. Variants with score = or < -2.5 are considered deleterious.Variants with score > -2.5 are considered neutral.
| ORGANISM_NAME | GENE_NAME | ENSEMBL_ID | DRUG_NAME | NUCLEOTIDE_POSITION | NUCLEOTIDE_MUTATION | AMINOACID_POSITION | AMINOACID_MUTATION | PROVEAN_SCORE | SAMPLE_LOCATION |
|---|---|---|---|---|---|---|---|---|---|
| Acinetobacter baumannii | gyrA | AO727_01490 | Quinolone | 248 | TCG - TTG | 83 | Ser - Leu | -4.408 | NA |
| Acinetobacter baumannii | gyrA | AO727_01490 | Quinolone | 260 | A - G | 87 | Glu - Gly | -3.412 | NA |
| Staphylococcus aureus | gyrA | AZ30_00030 | Fluoroquinolone | 251 | T - C | 84 | Leu - Ser | 4.659 | South Texas in United States |
| Staphylococcus aureus | gyrA | CH52_05420 | Fluoroquinolone (Ciprofloxacin) | 316 - 318 | NA | 106 | Gly - Asp | -6.748 | Hatay in turkey |
| Staphylococcus aureus | gyrA | CH52_05420 | Fluoroquinolone (Ciprofloxacin) | 251 | TCA - TTA | 84 | Ser - Leu | -4.66 | Hatay in turkey |
| Staphylococcus aureus | gyrA | CH52_05420 | Quinolone | 251 | TCA - TTA | 84 | Ser - Leu | -4.66 | NA |
| Staphylococcus aureus | gyrA | CH52_05420 | Fluoroquinolone | 251 | TCA - TTA | 84 | Ser - Leu | -4.66 | NA |
| Staphylococcus aureus | gyrA | CH52_05420 | Quinolone | 262 | GAA - AAA | 88 | Glu - Lys | -3.252 | NA |
| Staphylococcus aureus | gyrA | CH52_05420 | Quinolone | 253 | TCT - CCT | 85 | Ser - Pro | -2.752 | NA |
| Pseudomonas aeruginosa | gyrA | DQ20_03635 | Fluoroquinolone (Ciprofloxacin) | 259 | GAC - TAC | 87 | Asp - Tyr | -8.411 | Northern of Iran |
| Pseudomonas aeruginosa | gyrA | DQ20_03635 | Fluoroquinolone | 259 | GAC - AAC | 87 | Asp - Asn | -4.647 | Japan |
| Pseudomonas aeruginosa | gyrA | DQ20_03635 | Fluoroquinolone | 248 | ACC - ATC | 83 | Thr - Ile | -3.72 | Australia |
| Pseudomonas aeruginosa | gyrA | DQ20_03635 | Fluoroquinolone | 248 | ACC - ATC | 83 | Thr - Ile | -3.72 | Japan |
| Pseudomonas aeruginosa | gyrA | DQ20_03635 | Fluoroquinolone (Ciprofloxacin) | 248 | ACC - ATC | 83 | Thr - Ile | -3.72 | Northern of Iran |
| Pseudomonas aeruginosa | gyrA | DQ20_03635 | Fluoroquinolone (Ciprofloxacin) | 248 | ACC - ATC | 83 | Thr - Ile | -3.72 | Tunisia |
| Pseudomonas aeruginosa | gyrA | DQ20_03635 | Fluoroquinolone | 248 | ACC - ATC | 83 | Thr - Ile | -3.72 | Vietnam |
| Pseudomonas aeruginosa | gyrA | DQ20_03635 | Fluoroquinolone | 398 | ACG - ATG | 133 | Thr - Met | NA | Vietnam |
| Enterococcus faecium | gyrA | LK25_09795 | Fluoroquinolone | 247 - 249 | NA | 83 | Ser - Arg | NA | Gyeonggi Province in Korea |
| Enterococcus faecium | gyrA | LK25_09795 | Fluoroquinolone | 248 | AGC - ATC | 83 | Ser - Ile | NA | Gyeonggi Province in Korea |
| Enterococcus faecium | gyrA | LK25_09795 | Fluoroquinolone | 248 | C - T | 83 | Ser - Phe | NA | Gyeonggi Province in Korea |
| Enterococcus faecium | gyrA | LK25_09795 | Fluoroquinolone | 248 | C - A | 83 | Ser - Tyr | NA | Gyeonggi Province in Korea |
| Enterococcus faecium | gyrA | LK25_09795 | Fluoroquinolone (Levofloxacin) | 250 - 252 | NA | 84 | Ser - Arg | NA | Japan |
| Enterococcus faecium | gyrA | LK25_09795 | Fluoroquinolone (Levofloxacin) | 250 - 252 | NA | 84 | Ser - Ile | NA | Japan |
| Enterococcus faecium | gyrA | LK25_09795 | Fluoroquinolone (Levofloxacin) | 251 | C - A | 84 | Ser - Tyr | NA | Japan |
| Enterococcus faecium | gyrA | LK25_09795 | Fluoroquinolone | 260 | A - G | 87 | Glu - Gly | NA | Gyeonggi Province in Korea |
| Enterococcus faecium | gyrA | LK25_09795 | Fluoroquinolone (Levofloxacin) | 262 | G - C | 88 | Glu - Gln | NA | Japan |
| Enterococcus faecium | gyrA | LK25_09795 | Fluoroquinolone (Levofloxacin) | 263 | A - G | 88 | Glu - Gly | NA | Japan |
| Enterococcus faecium | gyrA | LK25_09795 | Fluoroquinolone (Levofloxacin) | 262 | G - A | 88 | Glu - Lys | NA | Japan |
| Enterobacter cloacae | gyrA | MC57_23210 | Fluoroquinolone (Ciprofloxacin / Levofloxacin) / Nalidixic Acid | 248 | TCC - TTC | 83 | Ser - Phe | NA | Argentina |
| Enterobacter cloacae | gyrA | MC57_23210 | Fluoroquinolone (Ciprofloxacin / Levofloxacin) / Nalidixic Acid | 248 | TCC - TAC | 83 | Ser - Tyr | NA | Argentina |
| Enterobacter cloacae | gyrA | MC57_23210 | Fluoroquinolone (Ciprofloxacin / Levofloxacin) / Nalidixic Acid | 260 | GAC - GCC | 87 | Asp - Ala | NA | Argentina |
| Enterobacter cloacae | gyrA | MC57_23210 | Fluoroquinolone (Ciprofloxacin / Levofloxacin) / Nalidixic Acid | 259 | GAC - AAC | 87 | Asp - Asn | NA | Argentina |
| Enterobacter cloacae | gyrA | MC57_23210 | Fluoroquinolone (Ciprofloxacin / Levofloxacin) / Nalidixic Acid | 260 | GAC - GGC | 87 | Asp - Gly | NA | Argentina |
| Klebsiella pneumoniae | gyrA | UUU_29370 | Fluoroquinolone (Ciprofloxacin / Levofloxacin) / Nalidixic Acid | 260 | NA | 87 | Asp - Ala | -7.171 | Argentina |
| Klebsiella pneumoniae | gyrA | UUU_29370 | Fluoroquinolone (Ciprofloxacin / Levofloxacin) / Nalidixic Acid | 260 | A - G | 87 | Asp - Gly | -6.368 | Argentina |
| Klebsiella pneumoniae | gyrA | UUU_29370 | Fluoroquinolone (Ciprofloxacin / Levofloxacin) / Nalidixic Acid | 248 | C - A | 83 | Ser - Tyr | -4.623 | Argentina |
| Klebsiella pneumoniae | gyrA | UUU_29370 | Fluoroquinolone (Ciprofloxacin / Levofloxacin) / Nalidixic Acid | 248 | C - T | 83 | Ser - Phe | -4.606 | Argentina |
| Klebsiella pneumoniae | gyrA | UUU_29370 | Quinolone | 259 | G - A | 87 | Asp - Asn | -4.46 | West Bengal in India |
| Klebsiella pneumoniae | gyrA | UUU_29370 | Quinolone | 248 | TCG - TTG | 83 | Ser - Leu | -4.3 | West Bengal in India |
| Klebsiella pneumoniae | gyrA | UUU_29370 | Fluoroquinolone (Ciprofloxacin / Levofloxacin) / Nalidixic Acid | 248 | AGC - ATC | 83 | Ser - Ile | -4.26 | Argentina |
| Enterobacter aerogenes | gyrA | NA | Fluoroquinolone (Ciprofloxacin / Levofloxacin) / Nalidixic Acid | 248 | ACC - ATC | 83 | Thr - Ile | NA | Argentina |