DRAGdb: Drug Resistance Associated Genes
Number of mutation entries of rpoB in ESKAPE bacteria is 73
PROVEAN score threshold is -2.5. Variants with score = or < -2.5 are considered deleterious.Variants with score > -2.5 are considered neutral.
| ORGANISM_NAME | GENE_NAME | ENSEMBL_ID | DRUG_NAME | NUCLEOTIDE_POSITION | NUCLEOTIDE_MUTATION | AMINOACID_POSITION | AMINOACID_MUTATION | PROVEAN_SCORE | SAMPLE_LOCATION |
|---|---|---|---|---|---|---|---|---|---|
| Acinetobacter baumannii | rpoB | AO727_11265 | Rifampicin | 1604 | CAT - CTT | 535 | His - Leu | -10.63 | NA |
| Acinetobacter baumannii | rpoB | AO727_11265 | Rifampicin | 1631 | CCT - CTT | 544 | Pro - Leu | -9.687 | NA |
| Acinetobacter baumannii | rpoB | AO727_11265 | Rifampicin | 1573 | GAC - TAC | 525 | Asp - Tyr | -8.616 | NA |
| Acinetobacter baumannii | rpoB | AO727_11265 | Rifampicin | 1574 | GAC - GTC | 525 | Asp - Val | -8.614 | NA |
| Acinetobacter baumannii | rpoB | AO727_11265 | Rifampicin | 1605 | CAT - CAA | 535 | His - Gln | -7.737 | NA |
| Acinetobacter baumannii | rpoB | AO727_11265 | Rifampin | 1742 | ATC - AAC | 581 | Ile - Asn | -6.808 | NA |
| Acinetobacter baumannii | rpoB | AO727_11265 | Rifampicin | 1603 | CAT - AAT | 535 | His - Asn | -6.765 | NA |
| Acinetobacter baumannii | rpoB | AO727_11265 | Rifampicin | 1574 | GAC - GGC | 525 | Asp - Gly | -6.568 | NA |
| Acinetobacter baumannii | rpoB | AO727_11265 | Rifampicin | 1561 | TCT - TTT | 521 | Ser - Phe | -5.824 | NA |
| Acinetobacter baumannii | rpoB | AO727_11265 | Rifampicin | 1619 | TCT - TAT | 540 | Ser - Tyr | -5.811 | NA |
| Acinetobacter baumannii | rpoB | AO727_11265 | Rifampicin | 1573 | GAC - AAC | 525 | Asp - Asn | -4.746 | NA |
| Acinetobacter baumannii | rpoB | AO727_11265 | Rifampicin | 1624 | CTT - TTT | 542 | Leu - Phe | -3.882 | NA |
| Acinetobacter baumannii | rpoB | AO727_11265 | Rifampicin | 1743 | ATC - ATG | 581 | Ile - Met | -2.919 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1556 | C - T | 519 | Pro - Leu | -9.001 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1442 | CAT - CTT | 481 | His - Leu | -8.897 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin / Methicillin | 2900 | A - T | 967 | Asn - Ile | -8.624 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1412 | A - T | 471 | Asp - Val | -8.064 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1441 | CAT - GAT | 481 | His - Asp | -6.833 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 2375 | A - G | 792 | Glu - Gly | -6.508 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Vancomycin | 1535 | G - C | 512 | Arg - Pro | -6.292 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1403 | CAA - CTA | 468 | Gln - Leu | -6.273 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 3223 - 3225 | NA | 1075 | Phe - Leu | -5.546 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1420 - 1422 | NA | 474 | Asn - Lys | -5.386 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1446 | AAA - AAT | 482 | Lys - Asp | -5.385 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1397 | TTA - TCA | 466 | Leu - Ser | -5.378 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Vancomycin | 1397 | T - C | 466 | Leu - Ser | -5.378 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1456 | TCA - TTA | 486 | Ser - Leu | -5.377 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1441 | CAT - TAT | 481 | His - Tyr | -4.956 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampin / Vancomycin | 141 | C - T | 481 | His - Tyr | -4.956 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampin / Vancomycin | 141 | C - T | 481 | His - Tyr | -4.956 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1411 | G - A | 471 | Asp - Asn | -4.479 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1451 | CGT - CAT | 484 | Arg - His | -4.478 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Vancomycin / Daptomycin | 1862 | C - A | 621 | Ala - Glu | -4.05 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 404 | T - C | 135 | Val - Ala | -3.645 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1402 | CAA - AAA | 468 | Gln - Lys | -3.582 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1403 | TCA - TTA | 468 | Gln - Arg | -3.581 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampin | 1394 | CAA - CGA | 465 | Gln - Arg | -3.388 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1430 | GCT - GAT | 477 | Ala - Asp | -3.146 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin / Daptomycin / Vancomycin / And Oxacillin | 1430 | GCT - GAT | 477 | Ala - Asp | -3.146 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1430 | C - T | 477 | Ala - Val | -3.131 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1581 | ATT - ATG | 527 | Ile - Met | -2.711 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1549 | GAA - CAA | 517 | Glu - Gln | -2.698 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1432 - 1434 | NA | 478 | Glu - Asp | -2.491 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1429 | G - T | 477 | Ala - Ser | -0.465 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1417 | G - T | 473 | Ala - Ser | 0.833 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampin | 1576 | C - A | 526 | His - Asn | NA | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampin | 1721 | C - T | 574 | Ser - Leu | NA | NA |
| Pseudomonas aeruginosa | rpoB | DQ20_13455 | Rifampicin | 455 | A - G | 152 | Gln - Arg | NA | NA |
| Pseudomonas aeruginosa | rpoB | DQ20_13455 | Rifampicin | 1550 | C - T | 517 | Ser - Leu | NA | NA |
| Pseudomonas aeruginosa | rpoB | DQ20_13455 | Rifampicin | 1553 | A - G | 518 | Gln - Arg | NA | NA |
| Pseudomonas aeruginosa | rpoB | DQ20_13455 | Rifampicin | 1553 | A - T | 518 | Gln - Leu | NA | NA |
| Pseudomonas aeruginosa | rpoB | DQ20_13455 | Rifampicin | 1563 | C - A | 521 | Asp - Glu | NA | NA |
| Pseudomonas aeruginosa | rpoB | DQ20_13455 | Rifampicin | 1562 | A - G | 521 | Asp - Gly | NA | NA |
| Pseudomonas aeruginosa | rpoB | DQ20_13455 | Rifampicin | 1562 | A - T | 521 | Asp - Val | NA | NA |
| Pseudomonas aeruginosa | rpoB | DQ20_13455 | Rifampicin | 1592 | A - G | 531 | His - Arg | NA | NA |
| Pseudomonas aeruginosa | rpoB | DQ20_13455 | Rifampicin | 1591 | C - G | 531 | His - Asp | NA | NA |
| Pseudomonas aeruginosa | rpoB | DQ20_13455 | Rifampicin | 1593 | C - A | 531 | His - Gln | NA | NA |
| Pseudomonas aeruginosa | rpoB | DQ20_13455 | Rifampicin | 1724 | G - C | 575 | Gly - Ala | NA | NA |
| Pseudomonas aeruginosa | rpoB | DQ20_13455 | Rifampicin | 1736 | C - T | 579 | Ser - Phe | NA | NA |
| Enterococcus faecium | rpoB | LK25_14925 | Rifampicin | 412 | GTT - ATT | 138 | Val - Ile | NA | NA |
| Enterococcus faecium | rpoB | LK25_14925 | Rifampicin | 412 | GTT - TTT | 138 | Val - Phe | NA | NA |
| Enterococcus faecium | rpoB | LK25_14925 | Rifampicin | 1427 | CAG - CGG | 476 | Gln - Arg | NA | NA |
| Enterococcus faecium | rpoB | LK25_14925 | Rifampicin | 1426 | C - A | 476 | Gln - Lys | NA | NA |
| Enterococcus faecium | rpoB | LK25_14925 | Rifampicin | 1435 | G - T | 479 | Asp - Tyr | NA | NA |
| Enterococcus faecium | rpoB | LK25_14925 | Rifampicin | 1436 | A - T | 479 | Asp - Val | NA | NA |
| Enterococcus faecium | rpoB | LK25_14925 | Rifampicin | 1454 | G - A | 485 | Gly - Asp | NA | NA |
| Enterococcus faecium | rpoB | LK25_14925 | Rifampicin | 1454 | G - T | 485 | Gly - Val | NA | NA |
| Enterococcus faecium | rpoB | LK25_14925 | Ceftriaxone / Rifampicin | 1456 | C - T | 486 | His - Tyr | NA | NA |
| Enterococcus faecium | rpoB | LK25_14925 | Rifampicin | 1466 | A - G | 489 | His - Arg | NA | NA |
| Enterococcus faecium | rpoB | LK25_14925 | Rifampicin | 1465 | C - G | 489 | His - Asp | NA | NA |
| Enterococcus faecium | rpoB | LK25_14925 | Rifampicin | 1466 | A - C | 489 | His - Pro | NA | NA |
| Enterococcus faecium | rpoB | LK25_14925 | Rifampicin | 1475 | G - A | 492 | Arg - His | NA | NA |
| Enterococcus faecium | rpoB | LK25_14925 | Rifampicin | 1481 | C - T | 494 | Ser - Leu | NA | NA |