DRAGdb: Drug Resistance Associated Genes
Number of mutation entries of gyrA in Mycobacterium tuberculosis is 105
PROVEAN score threshold is -2.5. Variants with score = or < -2.5 are considered deleterious.Variants with score > -2.5 are considered neutral.
| ORGANISM_NAME | GENE_NAME | ENSEMBL_ID | DRUG_NAME | NUCLEOTIDE_POSITION | NUCLEOTIDE_MUTATION | AMINOACID_POSITION | AMINOACID_MUTATION | PROVEAN_SCORE | SAMPLE_LOCATION |
|---|---|---|---|---|---|---|---|---|---|
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Moxifloxacin) | 569 | CCG - CTG | 190 | Pro - Leu | -9.946 | Taiwan |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 262 | GGC - TGC | 88 | Gly - Cys | -8.938 | Taiwan |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Moxifloxacin) | 262 | GGC - TGC | 88 | Gly - Cys | -8.938 | Taiwan |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Moxifloxacin) | 281 | GAC - GTC | 94 | Asp - Val | -8.824 | Taiwan |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 280 | GAC - TAC | 94 | Asp - Tyr | -8.817 | China |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 280 | GAC - TAC | 94 | Asp - Tyr | -8.817 | India |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ciprofloxacin) | 280 | GAC - TAC | 94 | Asp - Tyr | -8.817 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 280 | GAC - TAC | 94 | Asp - Tyr | -8.817 | Taiwan |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Moxifloxacin) | 280 | GAC - TAC | 94 | Asp - Tyr | -8.817 | Taiwan |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 281 | GAC - GCC | 94 | Asp - Ala | -7.811 | China |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 281 | GAC - GCC | 94 | Asp - Ala | -7.811 | India |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 281 | GAC - GCC | 94 | Asp - Ala | -7.811 | India |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ciprofloxacin) | 281 | GAC - GCC | 94 | Asp - Ala | -7.811 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ciprofloxacin / Ofloxacin / Sparfloxacin) | 281 | GAC - GCC | 94 | Asp - Ala | -7.811 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 281 | GAC - GCC | 94 | Asp - Ala | -7.811 | Taiwan |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Moxifloxacin) | 281 | GAC - GCC | 94 | Asp - Ala | -7.811 | Taiwan |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 281 | GAC - GCC | 94 | Asp - Ala | -7.811 | Morocco |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ciprofloxacin) | 280 | GAC - CAC | 94 | Asp - His | -6.839 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Moxifloxacin) | 280 | GAC - CAC | 94 | Asp - His | -6.839 | Taiwan |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 280 | GAC - CAC | 94 | Asp - His | -6.839 | Morocco |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 281 | GAC - GGC | 94 | Asp - Gly | -6.78 | United States |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 281 | GAC - GGC | 94 | Asp - Gly | -6.78 | China |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 281 | GAC - GGC | 94 | Asp - Gly | -6.78 | India |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ciprofloxacin) | 281 | GAC - GGC | 94 | Asp - Gly | -6.78 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 281 | GAC - GGC | 94 | Asp - Gly | -6.78 | Taiwan |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Moxifloxacin) | 281 | GAC - GGC | 94 | Asp - Gly | -6.78 | Taiwan |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 263 | GGC - GCC | 88 | Gly - Ala | -5.957 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 280 | GAC - AAC | 94 | Asp - Asn | -4.87 | United States |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 280 | GAC - AAC | 94 | Asp - Asn | -4.87 | China |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 280 | GAC - AAC | 94 | Asp - Asn | -4.87 | India |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ciprofloxacin) | 280 | GAC - AAC | 94 | Asp - Asn | -4.87 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ciprofloxacin / Ofloxacin / Sparfloxacin) | 280 | GAC - AAC | 94 | Asp - Asn | -4.87 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ciprofloxacin / Ofloxacin / Sparfloxacin) | 280 | GAC - AAC | 94 | Asp - Asn | -4.87 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 280 | GAC - AAC | 94 | Asp - Asn | -4.87 | Taiwan |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Moxifloxacin) | 280 | GAC - AAC | 94 | Asp - Asn | -4.87 | Taiwan |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 280 | GAC - AAC | 94 | Asp - Asn | -4.87 | Morocco |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 1151 | GCA - GTA | 384 | Ala - Val | -3.839 | Taiwan |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Moxifloxacin) | 1151 | GCA - GTA | 384 | Ala - Val | -3.839 | Taiwan |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 271 | TCG - CCG | 91 | Ser - Pro | -2.416 | United States |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 271 | TCG - CCG | 91 | Ser - Pro | -2.416 | China |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 271 | TCG - CCG | 91 | Ser - Pro | -2.416 | India |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ciprofloxacin) | 271 | TCG - CCG | 91 | Ser - Pro | -2.416 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 271 | TCG - CCG | 91 | Ser - Pro | -2.416 | Morocco |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 269 | GCG - GTG | 90 | Ala - Val | -2.409 | United States |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 269 | GCG - GTG | 90 | Ala - Val | -2.409 | China |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 269 | GCG - GTG | 90 | Ala - Val | -2.409 | India |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 269 | GCG - GTG | 90 | Ala - Val | -2.409 | India |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ciprofloxacin) | 269 | GCG - GTG | 90 | Ala - Val | -2.409 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ciprofloxacin / Ofloxacin / Sparfloxacin) | 269 | GCG - GTG | 90 | Ala - Val | -2.409 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 269 | GCG - GTG | 90 | Ala - Val | -2.409 | Morocco |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 269 | GCG - GGG | 90 | Ala - Gly | -1.566 | China |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 394 | GCC - TCC | 132 | Ala - Ser | -0.917 | Taiwan |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Moxifloxacin) | 394 | GCC - TCC | 132 | Ala - Ser | -0.917 | Taiwan |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 268 | GCG - ACG | 90 | Ala - Thr | 0.354 | Morocco |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 281 | GAC - GCC | 94 | Asp - Ala | -7.811 | Italy and Abhkazia |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 281 | GAC - GGC | 94 | Asp - Gly | -6.78 | Italy and Abhkazia |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 280 | GAC - AAC | 94 | Asp - Asn | -4.87 | Italy and Abhkazia |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 271 | TCG - CCG | 91 | Ser - Pro | -2.416 | Italy and Abhkazia |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 271 | TCG - CCG | 91 | Ser - Pro | -2.416 | Italy and Abhkazia |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 269 | GCG - GTG | 90 | Ala - Val | -2.409 | Italy and Abhkazia |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 269 | GCG - GTG | 90 | Ala - Val | -2.409 | Italy and Abhkazia |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 284 | AGC - ACC | 95 | Ser - Thr | 0.509 | Italy and Abhkazia |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 284 | AGC - ACC | 95 | Ser - Thr | 0.509 | Italy and Abhkazia |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 284 | AGC - ACC | 95 | Ser - Thr | 0.509 | Italy and Abhkazia |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 284 | AGC - ACC | 95 | Ser - Thr | 0.509 | Italy and Abhkazia |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 305 | CCC - CAC | 102 | Pro - His | -6.203 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 284 | AGC - ACC | 95 | Ser - Thr | 0.509 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 280 | GAC - TAC | 94 | Asp - Tyr | -8.817 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 281 | GAC - GCC | 94 | Asp - Ala | -7.811 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 280 | GAC - CAC | 94 | Asp - His | -6.839 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 281 | GAC - GGC | 94 | Asp - Gly | -6.78 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 280 | GAC - AAC | 94 | Asp - Asn | -4.87 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 271 | TCG - CCG | 91 | Ser - Pro | -2.416 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 269 | GCG - GTG | 90 | Ala - Val | -2.409 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 281 | GAC - GCC | 94 | Asp - Ala | -7.811 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 281 | GAC - GGC | 94 | Asp - Gly | -6.78 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 263 | GGC - GCC | 88 | Gly - Ala | -5.957 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 280 | GAC - AAC | 94 | Asp - Asn | -4.87 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 271 | TCG - CCG | 91 | Ser - Pro | -2.416 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 269 | GCG - GTG | 90 | Ala - Val | -2.409 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 280 - 281 | GAC - GTC | 94 | Asp - Phe | -8.828 | Philippines |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 281 | GAC - GTC | 94 | Asp - Val | -8.824 | India |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 263 | GGC - GCC | 88 | Gly - Ala | -5.957 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 265 | GAC - AAC | 89 | Asp - Asn | -4.968 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 325 | CTG - GTG | 109 | Leu - Val | -2.82 | India |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 269 | GCG - GGG | 90 | Ala - Gly | -1.566 | France |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 238 | ACC - GCC | 80 | Thr - Ala | -0.705 | France |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone | 220 | GCC - TCC | 74 | Ala - Ser | -0.438 | China |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 281 | GAC - GGC | 94 | Asp - Gly | -6.78 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 281 | GAC - GGC | 94 | Asp - Gly | -6.78 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 281 | GAC - GGC | 94 | Asp - Gly | -6.78 | Thailand |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin / Moxifloxacin / Gatifloxacin / Levofloxacin) | 281 | GAC - GGC | 94 | Asp - Gly | -6.78 | Thailand |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin / Moxifloxacin / Gatifloxacin / Levofloxacin) | 281 | GAC - GGC | 94 | Asp - Gly | -6.78 | Thailand |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 265 | GAC - AAC | 89 | Asp - Asn | -4.968 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 280 | GAC - AAC | 94 | Asp - Asn | -4.87 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin / Levofloxacin) | 280 | GAC - AAC | 94 | Asp - Asn | -4.87 | Thailand |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin / Moxifloxacin / Levofloxacin) | 280 | GAC - AAC | 94 | Asp - Asn | -4.87 | Thailand |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 271 | TCG - CCG | 91 | Ser - Pro | -2.416 | NA |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 269 | GCG - GTG | 90 | Ala - Val | -2.409 | Taiwan |
| Mycobacterium tuberculosis | gyrA | Rv0006 | Fluoroquinolone (Ofloxacin) | 269 | GCG - GTG | 90 | Ala - Val | -2.409 | NA |
| Mycobacterium tuberculosis complex | gyrA | NA | Fluoroquinolone (Ofloxacin) | 281 | GAC - GCC | 94 | Asp - Ala | NA | Nigeria |
| Mycobacterium tuberculosis complex | gyrA | NA | Fluoroquinolone (Ofloxacin) | 281 | GAC - GGC | 94 | Asp - Gly | NA | Nigeria |
| Mycobacterium tuberculosis complex | gyrA | NA | Fluoroquinolone (Ofloxacin) | 281 | GAC - GGC | 94 | Asp - Gly | NA | Nigeria |
| Mycobacterium tuberculosis complex | gyrA | NA | Fluoroquinolone (Ofloxacin) | 281 | GAC - GGC | 94 | Asp - Gly | NA | Nigeria |
| Mycobacterium tuberculosis complex | gyrA | NA | Fluoroquinolone (Ofloxacin) | 281 | GAC - GGC | 94 | Asp - Gly | NA | Nigeria |