DRAGdb: Drug Resistance Associated Genes
Number of mutation entries of gyrB in Mycobacterium tuberculosis is 69
PROVEAN score threshold is -2.5. Variants with score = or < -2.5 are considered deleterious.Variants with score > -2.5 are considered neutral.
| ORGANISM_NAME | GENE_NAME | ENSEMBL_ID | DRUG_NAME | NUCLEOTIDE_POSITION | NUCLEOTIDE_MUTATION | AMINOACID_POSITION | AMINOACID_MUTATION | PROVEAN_SCORE | SAMPLE_LOCATION |
|---|---|---|---|---|---|---|---|---|---|
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 1534 | GGG - AGG | 512 | Gly - Arg | -6.87 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 1496 | AAC - ACC | 499 | Asn - Thr | -5.132 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 1495 | AAC - GAC | 499 | Asn - Asp | -4.324 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 873 | ATG - ATC | 291 | Met - Ile | -3.319 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 1510 | GCG - ACG | 504 | Ala - Thr | -2.364 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 730 | CAC - AAC | 244 | His - Asn | -0.151 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 1498 | G - C | 500 | Asp - His | NA | United States |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 1528 | AAC - GAC | 510 | Asn - Asp | NA | Algeria |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 1613 | A - T | 538 | Asn - Ile | NA | United States |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 1616 | C - A | 539 | Thr - Asn | NA | United States |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1415 | GAC - GCC | 472 | Asp - Ala | -6.272 | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1531 | ACC - CCC | 511 | Thr - Pro | -4.899 | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1414 | GAC - CAC | 472 | Asp - His | -4.86 | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1414 | GAC - CAC | 472 | Asp - His | -4.86 | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1414 | GAC - AAC | 472 | Asp - Asn | -2.289 | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1414 | GAC - AAC | 472 | Asp - Asn | -2.289 | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1369 | CGT - TGT | 457 | Arg - Cys | NA | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1373 | TCC - TTC | 458 | Ser - Phe | NA | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1442 | GGT - GCT | 481 | Gly - Ala | NA | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1514 | GAC - GCC | 505 | Asp - Ala | NA | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1514 | GAC - GCC | 505 | Asp - Ala | NA | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1528 | AAC - GAC | 510 | Asn - Asp | NA | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1529 | AAC - ACC | 510 | Asn - Thr | NA | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1530 | AAC - AAA | 510 | Gln - Lys | NA | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 579 | A - T | 512 | Glu - Asp | NA | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1535 | GAA - GTA | 512 | Glu - Val | NA | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1543 | GCG - ACG | 515 | Ala - Thr | NA | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1544 | GCG - GTG | 515 | Ala - Val | NA | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1647 | CAA - CAT | 549 | Gln - His | NA | NA |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Moxifloxacin) | 1534 | GGG - AGG | 512 | Gly - Arg | -6.87 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Moxifloxacin) | 1534 | GGG - AGG | 512 | Gly - Arg | -6.87 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 1534 | GGG - AGG | 512 | Gly - Arg | -6.87 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Moxifloxacin) | 1496 | AAC - ACC | 499 | Asn - Thr | -5.132 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Moxifloxacin) | 1496 | AAC - ACC | 499 | Asn - Thr | -5.132 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 1496 | AAC - ACC | 499 | Asn - Thr | -5.132 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Moxifloxacin) | 1495 | AAC - GAC | 499 | Asn - Asp | -4.324 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Moxifloxacin) | 1495 | AAC - GAC | 499 | Asn - Asp | -4.324 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 1495 | AAC - GAC | 499 | Asn - Asp | -4.324 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Moxifloxacin) | 873 | ATG - ATC | 291 | Met - Ile | -3.319 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Moxifloxacin) | 873 | ATG - ATC | 291 | Met - Ile | -3.319 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 873 | ATG - ATC | 291 | Met - Ile | -3.319 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Moxifloxacin) | 1510 | GCG - ACG | 504 | Ala - Thr | -2.364 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Moxifloxacin) | 1510 | GCG - ACG | 504 | Ala - Thr | -2.364 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 1510 | GCG - ACG | 504 | Ala - Thr | -2.364 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Moxifloxacin) | 730 | CAC - AAC | 244 | His - Asn | -0.151 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Moxifloxacin) | 730 | CAC - AAC | 244 | His - Asn | -0.151 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 730 | CAC - AAC | 244 | His - Asn | -0.151 | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 1498 | G - C | 500 | Asp - His | NA | Tennessee in United States |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 1613 | A - T | 538 | Asn - Ile | NA | Tennessee in United States |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 1616 | C - A | 539 | Thr - Asn | NA | Tennessee in United States |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1414 | GAC - AAC | 472 | Asp - Asn | -2.289 | Thailand |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1415 | GAC - GCC | 472 | Asp - Ala | -6.272 | Vietnam |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1531 | ACC - CCC | 511 | Thr - Pro | -4.899 | Vietnam |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1414 | GAC - CAC | 472 | Asp - His | -4.86 | France |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1414 | GAC - CAC | 472 | Asp - His | -4.86 | Vietnam |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1414 | GAC - AAC | 472 | Asp - Asn | -2.289 | Vietnam |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1369 | CGT - TGT | 457 | Arg - Cys | NA | Uzbekistan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1373 | TCC - TTC | 458 | Ser - Phe | NA | Vietnam |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1442 | GGT - GCT | 481 | Gly - Ala | NA | Vietnam |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1528 | AAC - GAC | 510 | Asn - Asp | NA | France |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1530 | AAC - AAA | 510 | Gln - Lys | NA | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1529 | AAC - ACC | 510 | Asn - Thr | NA | Vietnam |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1536 | NA | 512 | Glu - Asp | NA | Vietnam |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1535 | GAA - GTA | 512 | Glu - Val | NA | Vietnam |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1543 | GCG - ACG | 515 | Ala - Thr | NA | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1544 | GCG - GTG | 515 | Ala - Val | NA | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone | 1647 | CAA - CAT | 549 | Gln - His | NA | Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 1457 | TCC - TTC | 486 | Ser - Phe | NA | northern Taiwan |
| Mycobacterium tuberculosis | gyrB | Rv0005 | Fluoroquinolone (Ofloxacin) | 1457 | TCC - TTC | 486 | Ser - Phe | NA | NA |