DRAGdb: Drug Resistance Associated Genes
Number of mutation entries in Bacillus species is 54
PROVEAN score threshold is -2.5. Variants with score = or < -2.5 are considered deleterious.Variants with score > -2.5 are considered neutral.
| ORGANISM_NAME | GENE_NAME | ENSEMBL_ID | DRUG_NAME | NUCLEOTIDE_POSITION | NUCLEOTIDE_MUTATION | AMINOACID_POSITION | AMINOACID_MUTATION | PROVEAN_SCORE | SAMPLE_LOCATION |
|---|---|---|---|---|---|---|---|---|---|
| Bacillus anthracis | gyrB | HYU01_00030 / HYU01_17875 | Fluoroquinolone | 1408 | AAC - GAC | 470 | Asn - Asp | -4.409 | NA |
| Bacillus subtilis | gidB / rsmG | EF83_13975 | Streptomycin | 313 | C - T | 105 | Arg - Trp | -7.955 | NA |
| Bacillus subtilis | gidB / rsmG | EF83_13975 | Streptomycin | 326 | T - A | 109 | Leu - Stop | NA | NA |
| Bacillus subtilis | gidB / rsmG | EF83_13975 | Streptomycin | 310 | A - AAA Insertion | 110 | Glu - Stop | NA | NA |
| Bacillus subtilis | gidB / rsmG | EF83_13975 | Streptomycin | 360 | T - TT | 126 | Asp - Stop | NA | NA |
| Bacillus subtilis | gidB / rsmG | EF83_13975 | Streptomycin | 499 - 541 | GC - Deletion | 167 | Gly - Stop | NA | NA |
| Bacillus subtilis | gidB / rsmG | EF83_13975 | Streptomycin | 528 - 708 | G to A - Deletion | 177 - 236 | Ala to Pro - Deletion | NA | NA |
| Bacillus subtilis | gidB / rsmG | EF83_13975 | Streptomycin | 606 - 644 | G to T - Deletion | 203 - 215 | Leu Ile - Deletion | -62.363 | NA |
| Bacillus subtilis | gidB / rsmG | EF83_13975 | Streptomycin | 574 | G - Deletion | 214 | Val - Stop | NA | NA |
| Bacillus subtilis | gidB / rsmG | EF83_13975 | Streptomycin | 558 | A - Deletion | 214 | Val - Stop | NA | NA |
| Bacillus subtilis | gidB / rsmG | EF83_13975 | Streptomycin | 125 | C - A | 42 | Thr - Asn | -4.97 | NA |
| Bacillus subtilis | gidB / rsmG | EF83_13975 | Streptomycin | 186 - 187 | TT - A | 70 | Val - Stop | NA | NA |
| Bacillus subtilis | gidB / rsmG | EF83_13975 | Streptomycin | 231 | AGCGGG - Insertion | 77 | Gly Ala - Insertion | NA | NA |
| Bacillus subtilis | gidB / rsmG | EF83_13975 | Streptomycin | 233 | C - A | 78 | Ala - Glu | -4.902 | NA |
| Bacillus subtilis | gidB / rsmG | EF83_13975 | Streptomycin | 231 - 236 | A to G - Deletion | 78 - 79 | Ala Gly - Deletion | -20.841 | NA |
| Bacillus subtilis | gidB / rsmG | EF83_13975 | Streptomycin | 242 | G - T | 81 | Gly - Val | -8.956 | NA |
| Bacillus subtilis | gidB / rsmG | EF83_13975 | Streptomycin | 659 | A - Deletion | NA | NA | NA | NA |
| Bacillus subtilis | rpoB | EF83_19560 | Rifampicin | 1400 | CTT - CCT | 467 | Leu - Pro | -6.273 | NA |
| Bacillus subtilis | rpoB | EF83_19560 | Rifampicin | 1406 | CAA - CTA | 469 | Gln - Leu | -6.27 | NA |
| Bacillus subtilis | rpoB | EF83_19560 | Rifampicin | 1406 | CAA - CGA | 469 | Gln - Arg | -3.58 | NA |
| Bacillus subtilis | rpoB | EF83_19560 | Rifampicin | 1405 | CAA - AAA | 469 | Gln - Lys | -3.58 | NA |
| Bacillus subtilis | rpoB | EF83_19560 | Rifampicin | 1433 | GCT - GTT | 478 | Ala - Val | -3.17 | NA |
| Bacillus subtilis | rpoB | EF83_19560 | Rifampicin | 1433 | GCT - GAT | 478 | Ala - Asn | -2.945 | NA |
| Bacillus subtilis | rpoB | EF83_19560 | Rifampicin | 1444 | CAC - TAC | 482 | His - Tyr | -5.124 | NA |
| Bacillus subtilis | rpoB | EF83_19560 | Rifampicin | 1445 | CAC - CCC | 482 | His - Pro | -8.4 | NA |
| Bacillus subtilis | rpoB | EF83_19560 | Rifampicin | 1445 | CAC - CGC | 482 | His - Arg | -6.606 | NA |
| Bacillus subtilis | rpoB | EF83_19560 | Rifampicin | 1444 | CAC - GAC | 482 | His - Asp | -7.343 | NA |
| Bacillus subtilis | rpoB | EF83_19560 | Rifampicin | 1444 | CAC - TAC | 482 | His - Tyr | -5.124 | NA |
| Bacillus subtilis | rpoB | EF83_19560 | Rifampicin | 1451 | CGT - CCT | 484 | Arg - Pro | -6.279 | NA |
| Bacillus subtilis | rpoB | EF83_19560 | Rifampicin | 1460 | TCA - TTA | 487 | Ser - Leu | -5.375 | NA |
| Bacillus subtilis | rpoB | EF83_19560 | Rifampicin | 1460 | TCA - TTA | 487 | Ser - Leu | -5.375 | NA |
| Bacillus subtilis | rpoB | EF83_19560 | Rifampicin | 1460 | TCA - TTA | 487 | Ser - Leu | -5.375 | NA |
| Bacillus subtilis | rpoB | EF83_19560 | Rifampicin | 1462 | GCA - CCA | 488 | Ala - Pro | -4.452 | NA |
| Bacillus subtilis | rpoB | EF83_19560 | Rifampicin | 1520 | CAC - CGC | 507 | His - Arg | -7.177 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 64 | C - T | 22 | Pro - Ser | -6.095 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 167 | AAA - ATA | 56 | Lys - Ile | -7.203 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 167 | AAA - ATA | 56 | Lys - Ile | -7.203 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 168 | AAA - AAT | 56 | Lys - Asn | -4.484 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 168 | AAA - AAT | 56 | Lys - Asn | -4.484 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 167 | AAA - AGA | 56 | Lys - Arg | -2.647 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 167 | AAA - AGA | 56 | Lys - Arg | -2.647 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 167 | AAA - ACA | 56 | Lys - Thr | -5.39 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 166 | AAA - CAA | 56 | Lys - Gln | -3.585 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 167 | AAA - AGA | 56 | Lys - Arg | -2.647 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 167 | AAA - ACA | 56 | Lys - Thr | -5.39 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 166 | AAA - CAA | 56 | Lys - Gln | -3.585 | NA |
| Bacillus velezensis | rpoB | NG74_00131 | Rifampicin | 1415 | A - G | 472 | Gln - Arg | NA | NA |
| Bacillus velezensis | rpoB | NG74_00131 | Rifampicin | 1453 | C - T | 485 | His - Tyr | NA | NA |
| Bacillus velezensis | rpoB | NG74_00131 | Rifampicin | 1453 - 1454 | CA - TG | 485 | His - Cys | NA | NA |
| Bacillus velezensis | rpoB | NG74_00131 | Rifampicin | 1454 | A - G | 485 | His - Arg | NA | NA |
| Bacillus velezensis | rpoB | NG74_00131 | Rifampicin | 1453 | C - G | 485 | His - Asp | NA | NA |
| Bacillus velezensis | rpoB | NG74_00131 | Rifampicin | 1469 | C - T | 490 | Ser - Leu | NA | NA |
| Bacillus velezensis | rpoB | NG74_00131 | Rifampicin | 1850 | C - T | 617 | Ser - Phe | NA | NA |
| Lysinibacillus sphaericus | rpsL | EP18_11520 | Streptomycin | 167 | A - G | 56 | Lys - Arg | NA | NA |