DRAGdb: Drug Resistance Associated Genes
Number of mutation entries in Clostridium species is 21
PROVEAN score threshold is -2.5. Variants with score = or < -2.5 are considered deleterious.Variants with score > -2.5 are considered neutral.
| ORGANISM_NAME | GENE_NAME | ENSEMBL_ID | DRUG_NAME | NUCLEOTIDE_POSITION | NUCLEOTIDE_MUTATION | AMINOACID_POSITION | AMINOACID_MUTATION | PROVEAN_SCORE | SAMPLE_LOCATION |
|---|---|---|---|---|---|---|---|---|---|
| Clostridium difficile | gyrA | BG47_01785 | Quinolone | 245 | C - T | 82 | Thr - Ile | -2.326 | Taiwan |
| Clostridium difficile | gyrB | BG47_01780 | Fluoroquinolone (Moxifloxacin) | 1096 | T - G | 366 | Ser - Ala | NA | China |
| Clostridium difficile | gyrB | BG47_01780 | Fluoroquinolone | 1096 | TCA - GCA | 366 | Ser - Ala | -0.464 | Shanghai in China |
| Clostridium difficile | gyrB | BG47_01780 | Fluoroquinolone (Moxifloxacin) | 1276 | GAT - AAT | 426 | Asp - Asn | NA | Brazil |
| Clostridium difficile | gyrB | BG47_01780 | Fluoroquinolone (Moxifloxacin) | 1276 | GAT - AAT | 426 | Asp - Asn | -4.341 | China |
| Clostridium difficile | gyrB | BG47_01780 | Fluoroquinolone (Moxifloxacin) | 1276 | GAT - AAT | 426 | Asp - Asn | NA | China |
| Clostridium difficile | gyrB | BG47_01780 | Fluoroquinolone (Moxifloxacin) | 1277 | GAT - GTT | 426 | Asp - Val | -8.564 | China |
| Clostridium difficile | gyrB | BG47_01780 | Fluoroquinolone (Moxifloxacin) | 1277 | GAT - GTT | 426 | Asp - Val | -8.564 | China |
| Clostridium difficile | gyrB | BG47_01780 | Fluoroquinolone (Ciprofloxacin / Moxifloxacin) | 1276 | GAT - AAT | 426 | Asp - Asn | -4.341 | France |
| Clostridium difficile | gyrB | BG47_01780 | Fluoroquinolone | 1277 | GAT - GTT | 426 | Asp - Val | -8.564 | NA |
| Clostridium difficile | gyrB | BG47_01780 | Fluoroquinolone (Moxifloxacin) | 1276 | GAT - AAT | 426 | Asp - Asn | NA | Pittsburgh in United States |
| Clostridium difficile | gyrB | BG47_01780 | Fluoroquinolone | 1276 | GAT - AAT | 426 | Asp - Asn | NA | Shanghai in China |
| Clostridium difficile | gyrB | BG47_01780 | Fluoroquinolone (Ciprofloxacin / Moxifloxacin) | 1340 | CGA - CTA | 447 | Arg - Leu | -6.331 | France |
| Clostridium difficile | gyrB | BG47_01780 | Fluoroquinolone (Moxifloxacin) | 1396 | G - A | 466 | Glu - Lys | -3.238 | Pittsburgh in United States |
| Clostridium difficile | rpoB | BG47_13730 | Rifampin | 1505 | C - A | 502 | His - Asn | -5.197 | NA |
| Clostridium difficile | rpoB | BG47_13730 | Rifampin | 1514 | G - A | 505 | Arg - Lys | -2.904 | NA |
| Clostridium difficile | rpoB | BG47_13730 | Rifampin | 1642 - 1644 | NA | 548 | Ile - Met | -2.897 | NA |
| Clostridium saccharoperbutylacetonicum | rpoB | Cspa_c01810 | Rifampicin | 1310 | A - G | 437 | His - Arg | NA | NA |
| Clostridium saccharoperbutylacetonicum | rpoB | Cspa_c01810 | Rifampicin | 1309 | C - T | 437 | His - Tyr | NA | NA |
| Clostridium saccharoperbutylacetonicum | rpoB | Cspa_c01810 | Rifampicin | 1514 | G - A | 505 | Arg - Lys | -2.879 | NA |
| Clostridium saccharoperbutylacetonicum | rpsL | Cspa_c01830 | Streptomycin | 129 | G - A | 43 | Lys - Asn | -4.489 | NA |