DRAGdb: Drug Resistance Associated Genes
Number of mutation entries in Escherichia coli species is 90
PROVEAN score threshold is -2.5. Variants with score = or < -2.5 are considered deleterious.Variants with score > -2.5 are considered neutral.
| ORGANISM_NAME | GENE_NAME | ENSEMBL_ID | DRUG_NAME | NUCLEOTIDE_POSITION | NUCLEOTIDE_MUTATION | AMINOACID_POSITION | AMINOACID_MUTATION | PROVEAN_SCORE | SAMPLE_LOCATION |
|---|---|---|---|---|---|---|---|---|---|
| Avian-pathogenic Escherichia coli | gyrA | NA | Fluoroquinolone (Ciprofloxacin) | 248 | TCG - TTG | 83 | Ser - Leu | NA | Egypt |
| Avian-pathogenic Escherichia coli | gyrA | NA | Fluoroquinolone (Ciprofloxacin) | 259 | G - A | 87 | Asp - Asn | NA | Egypt |
| Escherichia coli | gidB / rsmG | HUS2011_4511 | Streptomycin | 298 - 300 | NA | 100 | Lys - Ala | -5.985 | NA |
| Escherichia coli | gidB / rsmG | HUS2011_4511 | Streptomycin | 301 - 303 | NA | 101 | Arg - Ala | -5.985 | NA |
| Escherichia coli | gidB / rsmG | HUS2011_4511 | Streptomycin | 415 - 417 | NA | 139 | Arg - Ala | -5.966 | NA |
| Escherichia coli | gidB / rsmG | HUS2011_4511 | Streptomycin | 589 - 591 | NA | 197 | Arg - Ala | -5.953 | NA |
| Escherichia coli | gidB / rsmG | HUS2011_4511 | Streptomycin | 166 | G - A | 56 | Pro - Tyr | NA | NA |
| Escherichia coli | gidB / rsmG | HUS2011_4511 | Streptomycin | 167 | NA | 56 | Asp - Ala | -7.97 | NA |
| Escherichia coli | gidB / rsmG | HUS2011_4511 | Streptomycin | 212 | NA | 71 | Asp - Ala | -7.977 | NA |
| Escherichia coli | gidB / rsmG | HUS2011_4511 | Streptomycin | 224 | NA | 75 | Gly - Ala | -5.983 | NA |
| Escherichia coli | gidB / rsmG | HUS2011_4511 | Streptomycin | 230 | NA | 77 | Gly - Ala | -5.983 | NA |
| Escherichia coli | gidB / rsmG | HUS2011_4511 | Streptomycin | 235 | NA | 79 | Pro - Ala | -7.977 | NA |
| Escherichia coli | gidB / rsmG | HUS2011_4511 | Streptomycin | 259 - 261 | NA | 87 | Lys - Arg | NA | NA |
| Escherichia coli | gidB / rsmG | HUS2011_4511 | Streptomycin | 287 | NA | 96 | Asp - Ala | -7.98 | NA |
| Escherichia coli | gidB / rsmG | HUS2011_4511 | Streptomycin | 457 | A - Insertion | NA | NA | NA | NA |
| Escherichia coli | gidB / rsmG | HUS2011_4511 | Streptomycin | 448 - 472 | Deletion | NA | NA | NA | NA |
| Escherichia coli | gyrA | b2231 | Fluoroquinolone | 149 | A - G | 50 | Tyr - Cys | -5.587 | Mangalore in India |
| Escherichia coli | gyrA | b2231 | Fluoroquinolone (Ciprofloxacin / Levofloxacin) / Nalidixic Acid | 247 | TCG - GCG | 83 | Ser - Ala | -2.112 | Argentina |
| Escherichia coli | gyrA | b2231 | Fluoroquinolone (Ciprofloxacin / Levofloxacin) / Nalidixic Acid | 248 | TCG - TTG | 83 | Ser - Leu | -4.203 | Argentina |
| Escherichia coli | gyrA | b2231 | Quinolone | 248 | TCG - TTG | 83 | Ser - Leu | -4.203 | China |
| Escherichia coli | gyrA | b2231 | Fluoroquinolone | 248 | TCG - TTG | 83 | Ser - Leu | -4.203 | Mangalore in India |
| Escherichia coli | gyrA | b2231 | Fluoroquinolone (Ciprofloxacin) | 248 | TCG - TTG | 83 | Ser - Leu | -4.203 | NA |
| Escherichia coli | gyrA | b2231 | Fluoroquinolone (Ciprofloxacin) | 248 | TCG - TTG | 83 | Ser - Leu | -4.203 | NA |
| Escherichia coli | gyrA | b2231 | Nalidixic Acid / Fluoroquinolone (Ciprofloxacin) / Triclosan | 248 | C - T | 83 | Ser - Phe | -4.559 | NA |
| Escherichia coli | gyrA | b2231 | Nalidixic Acid | 247 | TCG - GCG | 83 | Ser - Ala | -2.112 | Taiwan |
| Escherichia coli | gyrA | b2231 | Nalidixic Acid | 248 | TCG - TTG | 83 | Ser - Leu | -4.203 | Taiwan |
| Escherichia coli | gyrA | b2231 | Fluoroquinolone | 248 | TCG - TTG | 83 | Ser - Leu | -4.203 | Korea |
| Escherichia coli | gyrA | b2231 | Fluoroquinolone (Ciprofloxacin / Levofloxacin) / Nalidixic Acid | 259 | G - A | 87 | Asp - Asn | -4.544 | Argentina |
| Escherichia coli | gyrA | b2231 | Fluoroquinolone (Ciprofloxacin / Levofloxacin) / Nalidixic Acid | 260 | A - G | 87 | Asp - Gly | -6.486 | Argentina |
| Escherichia coli | gyrA | b2231 | Fluoroquinolone (Ciprofloxacin / Levofloxacin) / Nalidixic Acid | 259 | G - T | 87 | Asp - Tyr | -8.258 | Argentina |
| Escherichia coli | gyrA | b2231 | Quinolone | 259 | G - A | 87 | Asp - Asn | -4.544 | China |
| Escherichia coli | gyrA | b2231 | Fluoroquinolone | 259 | G - A | 87 | Asp - Asn | -4.544 | Mangalore in India |
| Escherichia coli | gyrA | b2231 | Fluoroquinolone (Ciprofloxacin) | 259 | G - A | 87 | Asp - Asn | -4.544 | NA |
| Escherichia coli | gyrA | b2231 | Fluoroquinolone (Ciprofloxacin) | 260 | A - G | 87 | Asp - Gly | -6.486 | NA |
| Escherichia coli | gyrA | b2231 | Nalidixic Acid / Fluoroquinolone (Ciprofloxacin) / Triclosan | 260 | A - G | 87 | Asp - Gly | -6.486 | NA |
| Escherichia coli | gyrA | b2231 | Fluoroquinolone (Ciprofloxacin) | 259 | G - C | 87 | Asp - His | -6.331 | NA |
| Escherichia coli | gyrA | b2231 | Nalidixic Acid | 259 | G - A | 87 | Asp - Asn | -4.544 | Taiwan |
| Escherichia coli | gyrA | b2231 | Nalidixic Acid | 260 | NA | 87 | Asp - Gly | -6.486 | Taiwan |
| Escherichia coli | gyrA | b2231 | Nalidixic Acid | 259 | G - T | 87 | Asp - Tyr | -8.258 | Taiwan |
| Escherichia coli | gyrA | b2231 | Fluoroquinolone | 259 | G - A | 87 | Asp - Asn | -4.544 | Korea |
| Escherichia coli | gyrA | b2231 | Fluoroquinolone | 260 | A - G | 87 | Asp - Gly | -6.486 | Korea |
| Escherichia coli | gyrA | b2231 | Fluoroquinolone | 259 | G - C | 87 | Asp - His | -6.331 | Korea |
| Escherichia coli | gyrA | b2231 | Fluoroquinolone | 259 | G - T | 87 | Asp - Tyr | -8.258 | Korea |
| Escherichia coli | gyrB | HUS2011_4464 | Fluoroquinolone | 1276 | GAT - AAT | 426 | Asp - Asn | -3.588 | NA |
| Escherichia coli | gyrB | HUS2011_4464 | Fluoroquinolone (Ciprofloxacin) | 1306 | T - C | 431 | Ser - Pro | -3.546 | NA |
| Escherichia coli | gyrB | HUS2011_4464 | Fluoroquinolone | 1339 | A - G | 447 | Lys - Glu | -2.866 | NA |
| Escherichia coli | gyrB | HUS2011_4464 | Fluoroquinolone (Ciprofloxacin) | 1339 | A - G | 447 | Lys - Glu | -2.866 | Barcelona in Spain |
| Escherichia coli | gyrB | HUS2011_4464 | Nalidixic Acid | 1339 | A - G | 447 | Lys - Glu | -2.866 | NA |
| Escherichia coli | gyrB | HUS2011_4464 | Fluoroquinolone | 1372 | NA | 458 | Phe - Val | -4.932 | China |
| Escherichia coli | gyrB | HUS2011_4464 | Fluoroquinolone (Ciprofloxacin) | 1391 | C - T | 464 | Ser - Phe | -4.209 | NA |
| Escherichia coli | gyrB | HUS2011_4464 | Fluoroquinolone (Ciprofloxacin) | 1391 | C - A | 464 | Ser - Tyr | -4.21 | NA |
| Escherichia coli | gyrB | HUS2011_4464 | Fluoroquinolone (Moxifloxacin) | 1396 - 1398 | NA | 466 | Glu - Insertion | NA | NA |
| Escherichia coli | gyrB | HUS2011_4464 | Fluoroquinolone (Ciprofloxacin) | 1398 | A - T | 466 | Glu - Asp | -2.109 | Seoul in South Korea |
| Escherichia coli | gyrB | HUS2011_4464 | Fluoroquinolone | 1402 | G - C | 468 | Ala - Pro | -2.031 | China |
| Escherichia coli | gyrB | HUS2011_4464 | Nalidixic Acid / Fluoroquinolone (Ciprofloxacin) | 1475 | G - A | 492 | Ser - Asn | 0.469 | Korea |
| Escherichia coli | gyrB | HUS2011_4464 | Quinolone | 1475 | G - A | 492 | Ser - Asn | 0.469 | China |
| Escherichia coli | rpoB | HUS2011_4752 | Bicyclomycin | NA | NA | 1244 | His - Gln | -7.536 | NA |
| Escherichia coli | rpoB | HUS2011_4752 | Fluoroquinolone (Ciprofloxacin) | 3830 | C - T | 1277 | Ala - Val | -3.752 | NA |
| Escherichia coli | rpoB | HUS2011_4752 | Rifampicin | 436 | G - T | 146 | Val - Phe | -4.405 | NA |
| Escherichia coli | rpoB | HUS2011_4752 | Fluoroquinolone (Ciprofloxacin) | 1324 - 1335 | NA | 442 - 445 | Val Asp Asp Ile - Deletion | -30.61 | NA |
| Escherichia coli | rpoB | HUS2011_4752 | Fluoroquinolone (Ciprofloxacin) | 1363 - 1365 | NA | 455 | Ser - Duplication | -9.42 | NA |
| Escherichia coli | rpoB | HUS2011_4752 | Rifampicin | 1538 | A - T | 513 | Gln - Leu | -6.621 | NA |
| Escherichia coli | rpoB | HUS2011_4752 | Rifampicin | 1546 | G - A | 516 | Asp - Asn | -4.697 | NA |
| Escherichia coli | rpoB | HUS2011_4752 | Rifampin | 1547 | A - G | 516 | Asp - Gly | -6.558 | NA |
| Escherichia coli | rpoB | HUS2011_4752 | Rifampicin | 1551 | G - C | 517 | Gln - His | -4.738 | NA |
| Escherichia coli | rpoB | HUS2011_4752 | Rifampin | 1565 | C - T | 522 | Ser - Phe | -5.558 | NA |
| Escherichia coli | rpoB | HUS2011_4752 | Rifampicin | 1576 | C - T | 526 | His - Tyr | -5.684 | NA |
| Escherichia coli | rpoB | HUS2011_4752 | Rifampin | 1583 | G - A | 529 | Arg - His | -4.749 | NA |
| Escherichia coli | rpoB | HUS2011_4752 | Streptolydigin | 1631 | G - A | 544 | Gly - Asp | -6.655 | NA |
| Escherichia coli | rpoB | HUS2011_4752 | Streptolydigin | 1634 | T - C | 545 | Phe - Ser | -7.606 | NA |
| Escherichia coli | rpoB | HUS2011_4752 | Rifampicin | 1692 | C - T | 564 | Pro - Leu | -9.503 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 125 | A - C | 42 | Lys - Thr | -5.562 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 126 | NA | 42 | Lys - Ile | -7.465 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 125 | A - G | 42 | Lys - Arg | -2.591 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 126 | NA | 42 | Lys - Asn | -4.612 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 125 | AAA - AGA | 42 | Lys - Arg | -2.591 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 126 | AAA - AAC | 42 | Lys - Asn | -4.612 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 125 | AAA - ACA | 42 | Lys - Thr | -5.562 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 125 | AAA - ACA | 42 | Lys - Thr | -5.562 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 126 | A - C | 42 | Lys - Asn | -4.612 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 125 | AAA - ACA | 42 | Lys - Thr | -5.562 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 260 | AAA - AGA | 87 | Lys - Arg | -2.453 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 263 | AAA - AGA | 87 | Lys - Arg | -2.453 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 259 | A - G | 87 | Lys - Glu | -3.688 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 264 | A - C | 87 | Lys - Asn | -4.58 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 259 | AAA - GAA | 87 | Lys - Glu | -3.688 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 269 | CCG - CAG | 91 | Pro - Gln | -7.681 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 269 | CCG - CTG | 91 | Pro - Leu | -9.6 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 272 | GGT - GAT | 92 | Gly - Asp | -6.71 | NA |
| Escherichia coli | rrs | NA | Spectinomycin | 1192 | C - G | NA | NA | NA | NA |