DRAGdb: Drug Resistance Associated Genes
Number of mutation entries in Helicobacter pylori species is 94
PROVEAN score threshold is -2.5. Variants with score = or < -2.5 are considered deleterious.Variants with score > -2.5 are considered neutral.
| ORGANISM_NAME | GENE_NAME | ENSEMBL_ID | DRUG_NAME | NUCLEOTIDE_POSITION | NUCLEOTIDE_MUTATION | AMINOACID_POSITION | AMINOACID_MUTATION | PROVEAN_SCORE | SAMPLE_LOCATION |
|---|---|---|---|---|---|---|---|---|---|
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 385 | G - A | 129 | Ala - Thr | -2.994 | Indonesia |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 389 | G - A | 130 | Arg - Lys | -2.06 | Kathmandu in Nepal |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 401 | C - T | 134 | Ala - Val | 2.099 | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 419 | G - A | 140 | Arg - Lys | -0.57 | Indonesia |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 433 | G - A | 145 | Asp - Asn | -3.359 | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 445 | T - G | 149 | Phe - Val | -6.445 | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 481 | G - A | 161 | Asp - Asn | -1.475 | Indonesia |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 485 | T - C | 162 | Ile - Thr | -3.229 | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 514 | G - A | 172 | Val - Ile | 0.232 | Kathmandu in Nepal |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 562 | C - T | 188 | Pro - Ser | -7.747 | Kathmandu in Nepal |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 574 | G - A | 192 | Asp - Asn | -0.116 | Indonesia |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 579 | A - T | 193 | Glu - Asp | -2.9 | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 580 | A - T | 194 | Ile - Phe | -3.21 | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 589 - 591 | NA | 197 | Ala - Phe | -4.635 | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 100 | G - A | 34 | Asp - Asn | NA | Indonesia |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 100 | G - T | 34 | Asp - Tyr | NA | Indonesia |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 1303 | G - A | 435 | Asp - Asn | NA | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 1435 - 1437 | NA | 479 | Ser - Gly | NA | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 1435 - 1437 | NA | 479 | Ser - Gly | NA | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 1435 - 1437 | NA | 479 | Ser - Gly | NA | Indonesia |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 173 | A - G | 58 | Glu - Gly | -4.962 | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 187 | T - C | 63 | Ser - Pro | -0.772 | Kathmandu in Nepal |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 224 | G - T | 75 | Gly - Val | -8.823 | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 259 - 261 | NA | 87 | Asn - Ala | -0.011 | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 260 | A - T | 87 | Asn - Ile | -1.116 | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 261 | NA | 87 | Asn - Lys | -0.82 | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 260 | A - C | 87 | Asn - Thr | 2.101 | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone | 261 | C - A | 87 | Asn - Lys | -0.82 | France |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone | 261 | C - G | 87 | Asn - Lys | -0.82 | France |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone | 260 | C - T | 87 | Thr - Ile | NA | France |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 260 | A - T | 87 | Asn - Ile | -1.116 | Indonesia |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 261 | NA | 87 | Asn - Lys | -0.82 | Indonesia |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 259 | A - T | 87 | Asn - Tyr | -1.909 | Indonesia |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 260 | A - T | 87 | Asn - Ile | -1.116 | Kathmandu in Nepal |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 261 | NA | 87 | Asn - Lys | -0.82 | Kathmandu in Nepal |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 260 | A - T | 87 | Asn - Ile | -1.116 | Venezuela |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 260 | A - C | 87 | Asn - Thr | 2.101 | Venezuela |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone | 262 | G - C | 88 | Ala - Pro | -4.55 | France |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 262 | G - C | 88 | Ala - Pro | -4.55 | Kathmandu in Nepal |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 271 | G - A | 91 | Asp - Asn | -3.901 | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 272 | A - G | 91 | Asp - Gly | -5.952 | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 271 | G - T | 91 | Asp - Tyr | -7.358 | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone | 271 | G - A | 91 | Asp - Asn | -3.901 | France |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone | 272 | A - G | 91 | Asp - Gly | -5.952 | France |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone | 271 | G - C | 91 | Asp - His | -5.547 | France |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone | 271 | G - T | 91 | Asp - Tyr | -7.358 | France |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 271 | G - A | 91 | Asp - Asn | -3.901 | Indonesia |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 272 | A - G | 91 | Asp - Gly | -5.952 | Indonesia |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 271 | G - T | 91 | Asp - Tyr | -7.358 | Indonesia |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 271 | G - A | 91 | Asp - Asn | -3.901 | Kathmandu in Nepal |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 272 | A - G | 91 | Asp - Gly | -5.952 | Kathmandu in Nepal |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 271 | G - T | 91 | Asp - Tyr | -7.358 | Kathmandu in Nepal |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 271 | G - A | 91 | Asp - Asn | -3.901 | Venezuela |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 290 | C - T | 97 | Ala - Val | -3.915 | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 293 | A - T | 98 | Gln - Leu | -6.862 | Dominican Republic |
| Helicobacter pylori | gyrA | HP2RS_00240 / HP2RS_00245 | Fluoroquinolone (Levofloxacin) | 296 | A - T | 99 | Asp - Val | -7.389 | Kathmandu in Nepal |
| Helicobacter pylori | gyrB | HP2RS_04012 | Fluoroquinolone (Norfloxacin / Levofloxacin) | 481 | G - A | 161 | Ala - Thr | 1.251 | Japan |
| Helicobacter pylori | gyrB | HP2RS_04012 | Quinolone | 1189 - 1191 | NA | 397 | Ser - Gly | -2.29 | Beijing in China |
| Helicobacter pylori | gyrB | HP2RS_04012 | Fluoroquinolone (Levofloxacin) | 1303 | G - A | 435 | Asp - Asn | -3.651 | Kobe in Japan |
| Helicobacter pylori | gyrB | HP2RS_04012 | Fluoroquinolone | 1369 | T - G | 457 | Ser - Ala | -1.601 | Peking in China |
| Helicobacter pylori | gyrB | HP2RS_04012 | Fluoroquinolone (Norfloxacin / Levofloxacin) | 1387 | G - A | 463 | Glu - Lys | -1.878 | Japan |
| Helicobacter pylori | gyrB | HP2RS_04012 | Fluoroquinolone (Levofloxacin) | 1388 | A - G | 463 | Glu - Gly | -4.076 | Kobe in Japan |
| Helicobacter pylori | gyrB | HP2RS_04012 | Fluoroquinolone (Levofloxacin) | 1435 - 1437 | NA | 479 | Ser - Gly | -1.152 | Venezuela |
| Helicobacter pylori | gyrB | HP2RS_04012 | Fluoroquinolone (Levofloxacin) | 1435 - 1437 | NA | 479 | Ser - Gly | -1.152 | Indonesia |
| Helicobacter pylori | gyrB | HP2RS_04012 | Fluoroquinolone | 1443 | NA | 481 | Asp - Glu | -2.802 | Korea |
| Helicobacter pylori | gyrB | HP2RS_04012 | Fluoroquinolone (Levofloxacin) | 1446 | NA | 482 | Ile - Met | -0.787 | Kobe in Japan |
| Helicobacter pylori | gyrB | HP2RS_04012 | Fluoroquinolone (Levofloxacin) | 1447 | G - A | 483 | Glu - Lys | -1.791 | Nepal |
| Helicobacter pylori | gyrB | HP2RS_04012 | Fluoroquinolone (Levofloxacin) | 1451 | G - A | 484 | Arg - Lys | 2.18 | Indonesia |
| Helicobacter pylori | gyrB | HP2RS_04012 | Fluoroquinolone | 1451 | G - A | 484 | Arg - Lys | 2.18 | Korea |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifabutin | 445 | GTC - TTC | 149 | Val - Phe | -4.79 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampicin | 1573 - 1575 | NA | 525 | Leu - Ile | -1.943 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampicin / Rifabutin | 1573 - 1575 | NA | 525 | Leu - Ile | -1.943 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampicin | 1574 | T - C | 525 | Leu - Pro | -6.799 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampicin | 1577 | C - T | 526 | Ser - Leu | -5.826 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampicin | 1580 | A - G | 527 | Gln - Arg | -3.875 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampicin | 1579 | C - A | 527 | Gln - Lys | -3.877 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampin / Rifabutin | 1589 | A - G | 530 | Asp - Gly | -6.711 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampin / Rifabutin | 1590 | T - A | 530 | Asp - Glu | -3.828 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampin / Rifabutin | 1588 | G - A | 530 | Asp - Asn | -4.802 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampin / Rifabutin | 1588 | G - T | 530 | Asp - Tyr | -8.67 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampicin | 1588 | G - A | 530 | Asp - Asn | -4.802 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampicin | 1589 | A - G | 530 | Asp - Gly | -6.711 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampicin | 1588 | G - T | 530 | Asp - Tyr | -8.67 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampicin | 1589 | A - T | 530 | Asp - Val | -8.67 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampin / Rifabutin | 1618 | C - A | 540 | His - Asn | -6.686 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampicin | 1619 | A - G | 540 | His - Arg | -7.652 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampicin | 1618 | C - A | 540 | His - Asn | -6.686 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampicin | 1618 | C - T | 540 | His - Tyr | -5.739 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampin / Rifabutin | 1634 | C - T | 545 | Ser - Leu | -5.76 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampicin | 1757 | T - A | 586 | Ile - Asn | -6.691 | NA |
| Helicobacter pylori | rpoB | HP2RS_03753 | Rifampicin | 1756 - 1758 | NA | 586 | Ile - Pro | -6.658 | NA |
| Helicobacter pylori | rpsL | HP2RS_03782 | Streptomycin | 128 | AAA - AGA | 43 | Lys - Arg | -2.525 | NA |
| Helicobacter pylori | rpsL | HP2RS_03782 | Streptomycin | 128 | AAA - AGA | 43 | Lys - Arg | -2.525 | NA |
| Helicobacter pylori | rpsL | HP2RS_03782 | Streptomycin | 263 | AAG - AGG | 88 | Lys - Arg | -2.609 | NA |