DRAGdb: Drug Resistance Associated Genes
Number of mutation entries in other Mycobacterium species is 92
| ORGANISM_NAME | GENE_NAME | DRUG_NAME | NUCLEOTIDE_POSITION | NUCLEOTIDE_MUTATION | AMINOACID_POSITION | AMINOACID_MUTATION | MUTATION_TYPE | SAMPLE_LOCATION |
|---|---|---|---|---|---|---|---|---|
| Mycobacterium abscessus | gyrB | Fluoroquinolone | 1391 | NA | 464 | Ser - Asn | Non - Synonymous | China |
| Mycobacterium abscessus | rpsL | Streptomycin | 128 | A - G | 43 | Lys - Arg | Non - Synonymous | NA |
| Mycobacterium abscessus | rpsL | Streptomycin | 129 | NA | 43 | Lys - Asn | Non - Synonymous | NA |
| Mycobacterium abscessus | rpsL | Streptomycin | 263 | A - G | 88 | Lys - Arg | Non - Synonymous | NA |
| Mycobacterium africanum | KatG | Isoniazid | 944 | AGC - AAC | 315 | Ser - Asn | Non - Synonymous | Sierra Leone |
| Mycobacterium africanum | KatG | Isoniazid | 944 | AGC - ATC | 315 | Ser - Ile | Non - Synonymous | Sierra Leone |
| Mycobacterium africanum | KatG | Isoniazid | 944 | AGC - ACC | 315 | Ser - Thr | Non - Synonymous | Sierra Leone |
| Mycobacterium africanum | KatG | Isoniazid | 944 | AGC - ACC | 315 | Ser - Thr | Non - Synonymous | Uganda |
| Mycobacterium africanum | rpoB | Rifampin | 1552 - 1554 | AAC - Deletion | 518 | Asn - Deletion | Non - Synonymous | Sierra Leone and Uganda |
| Mycobacterium africanum | rpoB | Rifampin | 1577 | CAC - CGC | 526 | His - Arg | Non - Synonymous | Sierra Leone and Uganda |
| Mycobacterium africanum | rpoB | Rifampin | 1576 | CAC - TAC | 526 | His - Tyr | Non - Synonymous | Sierra Leone and Uganda |
| Mycobacterium africanum | rpoB | Rifampicin | 1592 | C - T | 531 | Ser - Leu | Non - Synonymous | Sierra Leone |
| Mycobacterium africanum | rpoB | Rifampin | 1592 | TCG - TTG | 531 | Ser - Leu | Non - Synonymous | Sierra Leone and Uganda |
| Mycobacterium avium | gyrB | Fluoroquinolone | 6416 | CAG - CGG | 2139 | Gln - Arg | Non - Synonymous | China |
| Mycobacterium avium | gyrB | Fluoroquinolone | 6436 | CTC - TTC | 2146 | Leu - Phe | Non - Synonymous | China |
| Mycobacterium avium | gyrB | Fluoroquinolone | 6480 | ATT - ATG | 2160 | Ile - Met | Non - Synonymous | China |
| Mycobacterium avium | gyrB | Fluoroquinolone | 6478 | ATT - GTT | 2160 | Ile - Val | Non - Synonymous | China |
| Mycobacterium avium | gyrB | Fluoroquinolone | 6817 | ATC - CTC | 2273 | Ile - Leu | Non - Synonymous | China |
| Mycobacterium avium | gyrB | Fluoroquinolone | 6820 | ACC - GCC | 2274 | Thr - Ala | Non - Synonymous | China |
| Mycobacterium avium | gyrB | Fluoroquinolone | 6902 | CTG - CGG | 2301 | Leu - Arg | Non - Synonymous | China |
| Mycobacterium avium | rpoB | Rifampicin | 1592 | C - G | 531 | Ser - Trp | Non - Synonymous | Belgium |
| Mycobacterium avium | rpoB | Rifampicin | 1592 | C - T | 531 | Ser - Leu | Non - Synonymous | United States |
| Mycobacterium bovis | rpoB | Rifampin / Rifabutin | 1592 | C - A | 531 | Ser - Tyr | Non - Synonymous | NA |
| Mycobacterium bovis | rpsL | Streptomycin | NA | GCT - GCG | NA | Ala - Ala | Non - Synonymous | NA |
| Mycobacterium bovis BCG | KatG | Isoniazid | 823 | A - C | 275 | Thr - Pro | Non - Synonymous | NA |
| Mycobacterium bovis BCG | KatG | Isoniazid | 944 | G - C | 315 | Ser - Thr | Non - Synonymous | NA |
| Mycobacterium bovis BCG | KatG | Isoniazid | 1142 | A - G | 381 | Asp - Gly | Non - Synonymous | NA |
| Mycobacterium caprae | rpsL | Streptomycin | NA | GCT - GCG | NA | Ala - Ala | Non - Synonymous | NA |
| Mycobacterium fortuitum | gyrA | Fluoroquinolone (Moxifloxacin) | 272 | TCG - TTG | 91 | Ser - Leu | Non - Synonymous | China |
| Mycobacterium fortuitum | gyrA | Fluoroquinolone (Moxifloxacin) | 272 | C - T | 91 | Ser - Leu | Non - Synonymous | Guangzhou in China |
| Mycobacterium fortuitum | gyrA | Fluoroquinolone (Moxifloxacin) | 283 | AGC - GGC | 95 | Ser - Gly | Non - Synonymous | China |
| Mycobacterium fortuitum | gyrA | Fluoroquinolone (Moxifloxacin) | 284 | A - G | 95 | Asp - Gly | Non - Synonymous | Guangzhou in China |
| Mycobacterium leprae | gyrA | Quinolone | 271 | G - A | 91 | Ala - Thr | Non - Synonymous | eastern Uttar Pradesh in India |
| Mycobacterium leprae | gyrA | Quinolone | 272 | GCA - GTA | 91 | Ala - Val | Non - Synonymous | eastern Uttar Pradesh in India |
| Mycobacterium leprae | gyrA | Fluoroquinolone (Ofloxacin) | 272 | C - T | 91 | Ala - Val | Non - Synonymous | NA |
| Mycobacterium leprae | gyrA | Quinolone | 274 | T - G | 92 | Ser - Ala | Non - Synonymous | eastern Uttar Pradesh in India |
| Mycobacterium leprae | rpoB | Rifampicin | 1271 | T - G | 424 | Val - Gly | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampicin | 1274 | C - T | 425 | Ser - Leu | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampin | 1274 | TCG - TTG | 425 | Ser - Leu | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampicin | 1276 | G - A | 426 | Ala - Thr | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampicin | 1294 | G - A | 432 | Gly - Ser | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampicin | 1298 | C - T | 433 | Thr - Ile | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampicin | 1312 - 1214 | NA | 438 | Gln - Val | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampicin | 1321 | G - T | 441 | Asp - Tyr | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampicin | 1351 | C - G | 451 | His - Asp | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampicin | 1351 | C - T | 451 | His - Tyr | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampicin | 1367 | C - T | 456 | Ser - Leu | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampicin | 1367 | C - T | 456 | Ser - Leu | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampicin | 1366 - 1368 | NA | 456 | Ser - Met | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampicin | 1367 | C - T | 456 | Ser - Phe | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampicin | 1372 - 1374 | NA | 458 | Leu - Val | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampicin | 1373 - 1374 | NA | 458 | Ser - Met | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampicin | 1513 - 1515 | NA | 505 | Arg - Trp | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampin | 1592 | C - T | 531 | Ser - Leu | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampin | 1591 - 1593 | TCG - ATG | 531 | Ser - Met | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampin | 1591 - 1593 | TCG - TTC | 531 | Ser - Phe | Non - Synonymous | NA |
| Mycobacterium leprae | rpoB | Rifampicin | 1592 | C - T | 531 | Ser - Leu | Non - Synonymous | Philippines |
| Mycobacterium leprae | rpoB | Rifampicin | 1592 | C - T | 531 | Ser - Leu | Non - Synonymous | Thailand |
| Mycobacterium leprae | rpoB | Rifampicin | 1592 | C - T | 531 | Ser - Leu | Non - Synonymous | United States |
| Mycobacterium leprae | rpoB | Rifampin | 1639 | G - A | 547 | Val - Ile | Non - Synonymous | NA |
| Mycobacterium smegmatis | gidB | Streptomycin | 437 | C - T | 146 | Ala - Val | Non - Synonymous | NA |
| Mycobacterium smegmatis | gidB | Streptomycin | 125 | G - A | 42 | Gly - Glu | Non - Synonymous | NA |
| Mycobacterium smegmatis | gidB | Streptomycin | 142 | G - A | 48 | Glu - Lys | Non - Synonymous | NA |
| Mycobacterium smegmatis | gidB | Streptomycin | 158 | G - A | 53 | Trp - Stop | Frameshift | NA |
| Mycobacterium smegmatis | gidB | Streptomycin | 157 | T - C | 53 | Trp - Arg | Non - Synonymous | NA |
| Mycobacterium smegmatis | gidB | Streptomycin | 163 | C - T | 55 | Arg - Trp | Non - Synonymous | NA |
| Mycobacterium smegmatis | gidB | Streptomycin | 205 | C - T | 69 | Pro - Ser | Non - Synonymous | NA |
| Mycobacterium smegmatis | gidB | Streptomycin | 233 | G - A | 78 | Ser - Asn | Non - Synonymous | NA |
| Mycobacterium smegmatis | gidB | Streptomycin | 248 | C - T | 83 | Pro - Leu | Non - Synonymous | NA |
| Mycobacterium smegmatis | gidB | Streptomycin | 301 | C - Deletion | NA | NA | Frameshift | NA |
| Mycobacterium smegmatis | gidB | Streptomycin | 205 | C - Deletion | NA | NA | Frameshift | NA |
| Mycobacterium smegmatis | gidB | Streptomycin | 208 | G - Insertion | NA | NA | Frameshift | NA |
| Mycobacterium smegmatis | gidB | Streptomycin | 103 | GCCGGC - Insertion | NA | Ala Gly - Insertion | Insertion | NA |
| Mycobacterium smegmatis | rpsL | Streptomycin | 128 | A - G | 43 | Lys - Arg | Non - Synonymous | NA |
| Mycobacterium smegmatis | rpsL | Streptomycin | 262 | A - G | 88 | Lys - Glu | Non - Synonymous | NA |
| Mycobacterium smegmatis | rpsL | Streptomycin | 272 | C - A | 91 | Pro - His | Non - Synonymous | NA |
| Mycobacterium smegmatis | rpsL | Streptomycin | NA | AAG - AGG | NA | Lys - Arg | Non - Synonymous | NA |
| Mycobacterium smegmatis | rpsL | Streptomycin | NA | AAG - AAC | NA | Lys - Asn | Non - Synonymous | NA |
| Mycobacterium smegmatis | rpsL | Streptomycin | NA | AAG - AAT | NA | Lys - Asn | Non - Synonymous | NA |
| Mycobacterium smegmatis | rpsL | Streptomycin | NA | AAG - ACG | NA | Lys - Thr | Non - Synonymous | NA |
| Mycobacterium smegmatis | rrs | Streptomycin | 522 | C - T | NA | NA | NA | NA |
| Mycobacterium smegmatis | rrs | Streptomycin | 523 | A - C | NA | NA | NA | NA |
| Mycobacterium smegmatis | rrs | Streptomycin | 524 | G - C | NA | NA | NA | NA |
| Mycobacterium smegmatis | rrs | Streptomycin | 526 | C - T | NA | NA | NA | NA |
| Mycobacterium smegmatis | rrs | Clarithromycin / Kanamycin / Gentamicin / Amikacin / Spectinomycin | 1192 | A - G | NA | NA | NA | NA |
| Mycobacterium smegmatis | rrs | Viomycin / Kanamycin | 1389 | A - G | NA | NA | NA | NA |
| Mycobacterium smegmatis | rrs | Clarithromycin / Kanamycin / Gentamicin / Amikacin / Spectinomycin | 1401 | A - G | NA | NA | NA | NA |
| Mycobacterium smegmatis | rrs | Viomycin / Kanamycin | 1473 | G - A | NA | NA | NA | NA |
| Mycobacterium ulcerans | KatG | Isoniazid | 944 | AGC - ACC | 315 | Ser - Thr | Non - Synonymous | Kazakhstan |
| Mycobacterium ulcerans | KatG | Isoniazid | 945 | AGC - ACC | 316 | Ser - Thr | Non - Synonymous | Germany |
| Mycobacterium ulcerans | KatG | Isoniazid | 1291 - 1293 | NA | 431 | Arg - Gly | Non - Synonymous | NA |
| Mycobacterium ulcerans | rpoB | Rifampicin | 1248 | TCC - GCC | 416 | Ser - Ala | Non - Synonymous | NA |