DRAGdb: Drug Resistance Associated Genes
Number of mutation entries in Shigella species is 19
PROVEAN score threshold is -2.5. Variants with score = or < -2.5 are considered deleterious.Variants with score > -2.5 are considered neutral.
| ORGANISM_NAME | GENE_NAME | ENSEMBL_ID | DRUG_NAME | NUCLEOTIDE_POSITION | NUCLEOTIDE_MUTATION | AMINOACID_POSITION | AMINOACID_MUTATION | PROVEAN_SCORE | SAMPLE_LOCATION |
|---|---|---|---|---|---|---|---|---|---|
| Shigella flexneri | gyrA | DP20_4113 | Nalidixic Acid / Fluoroquinolone (Norfloxacin) | 631 | CAC - TAC | 211 | His - Tyr | 1.544 | Jiangsu Province of China |
| Shigella flexneri | gyrA | DP20_4113 | Nalidixic Acid / Fluoroquinolone (Norfloxacin) | 171 | AAT - AAA | 57 | Asn - Lys | -5.764 | Jiangsu Province of China |
| Shigella flexneri | gyrA | DP20_4113 | Nalidixic Acid / Fluoroquinolone (Norfloxacin) | 239 | CAT - CCT | 80 | His - Pro | -9.651 | Jiangsu Province of China |
| Shigella flexneri | gyrA | DP20_4113 | Nalidixic Acid / Fluoroquinolone (Norfloxacin) | 248 | TCG - TTG | 83 | Ser - Leu | -4.203 | Jiangsu Province of China |
| Shigella flexneri | gyrA | DP20_4113 | Nalidixic Acid / Fluoroquinolone (Norfloxacin) | 260 | GAC - GCC | 87 | Asp - Ala | -7.306 | Jiangsu Province of China |
| Shigella flexneri | gyrA | DP20_4113 | Nalidixic Acid / Fluoroquinolone (Norfloxacin) | 259 | GAC - AAC | 87 | Asp - Asn | -4.544 | Jiangsu Province of China |
| Shigella flexneri | gyrA | DP20_4113 | Nalidixic Acid / Fluoroquinolone (Norfloxacin) | 260 | GAC - GGC | 87 | Asp - Gly | -6.486 | Jiangsu Province of China |
| Shigella flexneri | gyrA | DP20_4113 | Nalidixic Acid / Fluoroquinolone (Norfloxacin) | 259 | GAC - TAC | 87 | Asp - Tyr | -8.258 | Jiangsu Province of China |
| Shigella flexneri | gyrA | DP20_4113 | Nalidixic Acid / Fluoroquinolone (Norfloxacin) | 260 | GAC - GTC | 87 | Asp - Val | -8.27 | Jiangsu Province of China |
| Shigella flexneri 2a | gyrA | ERS574920_03941 | Fluoroquinolone | 248 | TCG - TTG | 83 | Ser - Leu | -4.203 | Northwest China |
| Shigella flexneri 2a | gyrA | ERS574920_03941 | Fluoroquinolone | 259 | G - A | 87 | Asp - Asn | -4.544 | Northwest China |
| Shigella flexneri 2a | gyrA | ERS574920_03941 | Fluoroquinolone | 259 | G - T | 87 | Asp - Tyr | -8.258 | Northwest China |
| Shigella sonnei | gyrA | ERS127223_04184 | Fluoroquinolone | 248 | TCG - TTG | 83 | Ser - Leu | -4.203 | Jiangsu Province of China |
| Shigella sonnei | gyrA | ERS127223_04184 | Fluoroquinolone | 259 | GAC - AAC | 87 | Asp - Asn | -4.544 | Jiangsu Province of China |
| Shigella sonnei | gyrA | ERS127223_04184 | Fluoroquinolone | 260 | GAC - GCC | 87 | Asp - Gly | -6.486 | Jiangsu Province of China |
| Shigella sps. | gyrA | NA | Quinolone | 247 | TCG - GCG | 83 | Ser - Ala | NA | Tehran in Iran |
| Shigella sps. | gyrA | NA | Quinolone | 248 | TCG - TTG | 83 | Ser - Leu | NA | Tehran in Iran |
| Shigella sps. | gyrA | NA | Quinolone | 260 | GAC - GGC | 87 | Asp - Gly | NA | Tehran in Iran |
| Shigella sps. | gyrA | NA | Quinolone | 259 | GAC - TAC | 87 | Asp - Tyr | NA | Tehran in Iran |