DRAGdb: Drug Resistance Associated Genes
Number of mutation entries in Staphylococcus species is 78
PROVEAN score threshold is -2.5. Variants with score = or < -2.5 are considered deleterious.Variants with score > -2.5 are considered neutral.
| ORGANISM_NAME | GENE_NAME | ENSEMBL_ID | DRUG_NAME | NUCLEOTIDE_POSITION | NUCLEOTIDE_MUTATION | AMINOACID_POSITION | AMINOACID_MUTATION | PROVEAN_SCORE | SAMPLE_LOCATION |
|---|---|---|---|---|---|---|---|---|---|
| Staphylococcus aureus | gidB / rsmG | CH52_05470 | Streptomycin | 465 | T - G | 155 | Ser - Arg | -4.38 | NA |
| Staphylococcus aureus | gidB / rsmG | CH52_05470 | Streptomycin | 652 | A - Deletion | NA | NA | NA | NA |
| Staphylococcus aureus | gyrA | CH52_05420 | Fluoroquinolone (Ciprofloxacin) | 316 - 318 | NA | 106 | Gly - Asp | -6.748 | Hatay in turkey |
| Staphylococcus aureus | gyrA | CH52_05420 | Fluoroquinolone (Ciprofloxacin) | 251 | TCA - TTA | 84 | Ser - Leu | -4.66 | Hatay in turkey |
| Staphylococcus aureus | gyrA | CH52_05420 | Quinolone | 251 | TCA - TTA | 84 | Ser - Leu | -4.66 | NA |
| Staphylococcus aureus | gyrA | AZ30_00030 | Fluoroquinolone | 251 | T - C | 84 | Leu - Ser | 4.659 | South Texas in United States |
| Staphylococcus aureus | gyrA | CH52_05420 | Fluoroquinolone | 251 | TCA - TTA | 84 | Ser - Leu | -4.66 | NA |
| Staphylococcus aureus | gyrA | CH52_05420 | Quinolone | 253 | TCT - CCT | 85 | Ser - Pro | -2.752 | NA |
| Staphylococcus aureus | gyrA | CH52_05420 | Quinolone | 262 | GAA - AAA | 88 | Glu - Lys | -3.252 | NA |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Novobiocin | 305 | ATT - AGT | 102 | Ile - Ser | -3.588 | NA |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Novobiocin | 305 | ATT - AGT | 102 | Ile - Ser | -3.588 | NA |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Novobiocin | 305 | ATT - ACT | 102 | Ile - Thr | -2.688 | NA |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Novobiocin | 383 | TCA - TTA | 128 | Ser - Leu | -0.838 | NA |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Novobiocin | 431 | AGA - ATA | 144 | Arg - Ile | -5.475 | NA |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Novobiocin | 432 | AGA - AGT | 144 | Arg - Ser | -3.785 | NA |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Novobiocin | 432 | AGA - AGT | 144 | Arg - Ser | -3.785 | NA |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Novobiocin | 432 | AGA - AGT | 144 | Arg - Ser | -3.785 | NA |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Novobiocin | 517 | ACT - GCT | 173 | Thr - Ala | -4.284 | NA |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Fluoroquinolone (Sparfloxacin) | 1213 - 1227 | NA | 405 - 409 | deletion | NA | NA |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Fluoroquinolone | 1497 | T - C | 439 | Ala - Ala | 0 | Egypt |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Fluoroquinolone | 1578 | A - G | 465 | Lys - Lys | NA | Egypt |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Quinolone | 1423 | A - G | 475 | Asn - Asp | -4.292 | NA |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Quinolone | 1431 | A - T | 477 | Glu - Asp | -2.727 | NA |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Non-Fluorinated Quinolones | 1429 - 1431 | NA | 477 | Glu - Val | -6.347 | NA |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Novobiocin | 167 | ATC - AGC | 56 | Ile - Ser | -4.351 | NA |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Novobiocin | 253 | GGT - AGT | 85 | Gly - Ser | -4.356 | NA |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Novobiocin | 266 | GAT - GGT | 89 | Asp - Gly | -1.022 | NA |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Fluoroquinolone (Ciprofloxacin) | 1579 | A - G | NA | NA | NA | NA |
| Staphylococcus aureus | gyrB | CH52_05425 / CH52_12295 | Fluoroquinolone (Ciprofloxacin) | 1579 | A - G | NA | NA | NA | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 3223 - 3225 | NA | 1075 | Phe - Leu | -5.546 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 404 | T - C | 135 | Val - Ala | -3.645 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampin | 1394 | CAA - CGA | 465 | Gln - Arg | -3.388 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1397 | TTA - TCA | 466 | Leu - Ser | -5.378 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Vancomycin | 1397 | T - C | 466 | Leu - Ser | -5.378 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1403 | TCA - TTA | 468 | Gln - Arg | -3.581 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1403 | CAA - CTA | 468 | Gln - Leu | -6.273 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1402 | CAA - AAA | 468 | Gln - Lys | -3.582 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1411 | G - A | 471 | Asp - Asn | -4.479 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1412 | A - T | 471 | Asp - Val | -8.064 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1417 | G - T | 473 | Ala - Ser | 0.833 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1420 - 1422 | NA | 474 | Asn - Lys | -5.386 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1430 | GCT - GAT | 477 | Ala - Asp | -3.146 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin / Daptomycin / Vancomycin / And Oxacillin | 1430 | GCT - GAT | 477 | Ala - Asp | -3.146 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1429 | G - T | 477 | Ala - Ser | -0.465 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1430 | C - T | 477 | Ala - Val | -3.131 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1432 - 1434 | NA | 478 | Glu - Asp | -2.491 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1441 | CAT - GAT | 481 | His - Asp | -6.833 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1442 | CAT - CTT | 481 | His - Leu | -8.897 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1441 | CAT - TAT | 481 | His - Tyr | -4.956 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampin / Vancomycin | 141 | C - T | 481 | His - Tyr | -4.956 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampin / Vancomycin | 141 | C - T | 481 | His - Tyr | -4.956 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1446 | AAA - AAT | 482 | Lys - Asp | -5.385 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1451 | CGT - CAT | 484 | Arg - His | -4.478 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1456 | TCA - TTA | 486 | Ser - Leu | -5.377 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Vancomycin | 1535 | G - C | 512 | Arg - Pro | -6.292 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1549 | GAA - CAA | 517 | Glu - Gln | -2.698 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1556 | C - T | 519 | Pro - Leu | -9.001 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampin | 1576 | C - A | 526 | His - Asn | NA | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 1581 | ATT - ATG | 527 | Ile - Met | -2.711 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampin | 1721 | C - T | 574 | Ser - Leu | NA | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Vancomycin / Daptomycin | 1862 | C - A | 621 | Ala - Glu | -4.05 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin | 2375 | A - G | 792 | Glu - Gly | -6.508 | NA |
| Staphylococcus aureus | rpoB | CH52_03045 | Rifampicin / Methicillin | 2900 | A - T | 967 | Asn - Ile | -8.624 | NA |
| Staphylococcus epidermidis | gyrA | EL82_09050 | Fluoroquinolone | 251 | C - T | 84 | Ser - Phe | -4.996 | NA |
| Staphylococcus epidermidis | gyrA | EL82_09050 | Fluoroquinolone | 251 | C - A | 84 | Ser - Tyr | -5.024 | NA |
| Staphylococcus epidermidis | rpoB | EL82_01845 | Rifampicin | 1378 | G - C | 460 | Glu - Gln | NA | NA |
| Staphylococcus epidermidis | rpoB | EL82_01845 | Rifampicin | 1406 | A - G | 469 | Gln - Arg | NA | NA |
| Staphylococcus epidermidis | rpoB | EL82_01845 | Rifampicin | 1406 | A - T | 469 | Gln - Leu | NA | NA |
| Staphylococcus epidermidis | rpoB | EL82_01845 | Rifampicin | 1405 | C - A | 469 | Gln - Lys | NA | NA |
| Staphylococcus epidermidis | rpoB | EL82_01845 | Rifampicin | 1414 | G - T | 472 | Asp - Tyr | NA | NA |
| Staphylococcus epidermidis | rpoB | EL82_01845 | Rifampicin | 1445 | A - G | 482 | His - Arg | NA | NA |
| Staphylococcus epidermidis | rpoB | EL82_01845 | Rifampicin | 1444 | C - T | 482 | His - Asp | NA | NA |
| Staphylococcus epidermidis | rpoB | EL82_01845 | Rifampicin | 1444 | C - T | 482 | His - Tyr | NA | NA |
| Staphylococcus epidermidis | rpoB | EL82_01845 | Rifampicin | 1454 | G - A | 485 | Arg - His | NA | NA |
| Staphylococcus epidermidis | rpoB | EL82_01845 | Rifampicin | 1459 - 1461 | NA | 487 | Ser - Cys | NA | NA |
| Staphylococcus epidermidis | rpoB | EL82_01845 | Rifampicin | 1460 | C - T | 487 | Ser - Phe | NA | NA |
| Staphylococcus epidermidis | rpoB | EL82_01845 | Rifampicin | 1460 | C - A | 487 | Ser - Tyr | NA | NA |
| Staphylococcus pseudintermedius | gyrA | NO89_11120 | Fluoroquinolone | 251 | C - T | 84 | Ser - Leu | -4.988 | NA |