DRAGdb: Drug Resistance Associated Genes
Number of mutation entries in Streptococcus species is 82
PROVEAN score threshold is -2.5. Variants with score = or < -2.5 are considered deleterious.Variants with score > -2.5 are considered neutral.
| ORGANISM_NAME | GENE_NAME | ENSEMBL_ID | DRUG_NAME | NUCLEOTIDE_POSITION | NUCLEOTIDE_MUTATION | AMINOACID_POSITION | AMINOACID_MUTATION | PROVEAN_SCORE | SAMPLE_LOCATION |
|---|---|---|---|---|---|---|---|---|---|
| Streptococcus agalactiae (group B streptococcus [GBS]) | gyrB | GBS222_0521 | Fluoroquinolone (Levofloxacin) | 928 - 930 | NA | 310 | Lys - Arg | -1.473 | Italy |
| Streptococcus agalactiae (group B streptococcus [GBS]) | gyrB | GBS222_0521 | Fluoroquinolone (Levofloxacin) | 1382 | T - A | 461 | Ile - Asn | -6.306 | Italy |
| Streptococcus agalactiae (group B streptococcus [GBS]) | gyrB | GBS222_0521 | Fluoroquinolone (Levofloxacin) | 1451 | C - T | 484 | Ala - Val | -3.587 | Italy |
| Streptococcus agalactiae (group B streptococcus [GBS]) | gyrB | GBS222_0521 | Fluoroquinolone (Levofloxacin) | 1476 | NA | 492 | Asp - Glu | -1.215 | Italy |
| Streptococcus agalactiae (group B streptococcus [GBS]) | gyrB | GBS222_0521 | Fluoroquinolone (Levofloxacin) | 1487 | C - T | 496 | Ser - Leu | -3.938 | Italy |
| Streptococcus agalactiae (group B streptococcus [GBS]) | gyrB | GBS222_0521 | Fluoroquinolone (Levofloxacin) | 1493 | T - C | 498 | Val - Ala | NA | Italy |
| Streptococcus agalactiae (group B streptococcus [GBS]) | gyrB | GBS222_0521 | Fluoroquinolone (Levofloxacin) | 1492 - 1494 | NA | 498 | Val - Cys | NA | Italy |
| Streptococcus agalactiae (group B streptococcus [GBS]) | gyrB | GBS222_0521 | Fluoroquinolone (Levofloxacin) | 1448 - 1500 | NA | 500 | Tyr - Gln | -7.072 | Italy |
| Streptococcus agalactiae (group B streptococcus [GBS]) | gyrB | GBS222_0521 | Fluoroquinolone (Levofloxacin) | 1503 | NA | 501 | Phe - Lys | NA | Italy |
| Streptococcus iniae | gyrB | DQ08_05990 / DQ08_04155 | Novobiocin | 1905 | AGA - AGC | 635 | Arg - Ser | -4.044 | Israel |
| Streptococcus mitis | gyrB | SK608_0821 | Fluoroquinolone (Ciprofloxacin) | 1480 - 1482 | NA | 494 | Ser - Thr | -1.52 | Barcelona in Spain |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin / Moxifloxacin) | 340 - 342 | NA | 114 | Ser - Gly | 2.033 | Netherlands |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin / Moxifloxacin) | 340 - 342 | NA | 114 | Ser - Gly | 2.033 | Spain |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin / Moxifloxacin) | 98 | C - A | 33 | Pro - His | -8.38 | Colombia |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin) | 242 | C - T | 81 | Ser - Phe | -5.583 | Aachen in Germany |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin) | 242 | C - A | 81 | Ser - Tyr | -5.588 | Aachen in Germany |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin / Moxifloxacin) | 242 | C - T | 81 | Ser - Phe | -5.583 | Colombia |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin / Moxifloxacin) | 242 | C - G | 81 | Ser - Trp | -6.553 | Netherlands |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin / Moxifloxacin) | 242 | C - T | 81 | Ser - Phe | -5.583 | Spain |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin / Moxifloxacin) | 242 | C - A | 81 | Ser - Tyr | -5.588 | Spain |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin / Moxifloxacin) | 242 | C - T | 81 | Ser - Phe | -5.583 | Sweden |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin / Moxifloxacin) | 242 | C - T | 81 | Ser - Phe | -5.583 | Taiwan |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin / Moxifloxacin) | 242 | C - A | 81 | Ser - Tyr | -5.588 | Taiwan |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin / Sitafloxacin / Tosufloxacin / Garenoxacin) | 242 | C - T | 81 | Ser - Phe | -5.583 | Tohoku area in Japan |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin / Sitafloxacin / Tosufloxacin / Garenoxacin) | 242 | C - A | 81 | Ser - Tyr | -5.588 | Tohoku area in Japan |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin) | 254 | A - C | 85 | Glu - Ala | -5.175 | Aachen in Germany |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin) | 254 | A - G | 85 | Glu - Gly | -5.862 | Aachen in Germany |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin) | 253 | G - A | 85 | Glu - Lys | -3.517 | Aachen in Germany |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin / Moxifloxacin) | 253 | G - A | 85 | Glu - Lys | -3.517 | Colombia |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin / Moxifloxacin) | 253 | G - A | 85 | Glu - Lys | -3.517 | Spain |
| Streptococcus pneumoniae | gyrA | DB40_02095 | Fluoroquinolone (Levofloxacin / Sitafloxacin / Tosufloxacin / Garenoxacin) | 253 | G - A | 85 | Glu - Lys | -3.517 | Tohoku area in Japan |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone (Levofloxacin) | 889 | G - T | 297 | Ala - Ser | -2.547 | NA |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone (Levofloxacin) | 1136 | G - T | 379 | Arg - Leu | -1.342 | NA |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone | 1169 | C - T | 390 | Ala - Val | -3.607 | Philippines |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone (Trovafloxacin / Clinafloxacin) | 1216 | G - A | 406 | Gly - Ser | -1.634 | NA |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone (Moxifloxacin) | 1685 - 1695 | CTTCCAGGGAA - Deletion | 412 - 414 | Leu Pro Gly - Deletion | -27.035 | NA |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone | 1268 | A - C | 423 | Asn - Thr | -2.338 | Philippines |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone (Gemifloxacin) | 1276 | G - A | 426 | Glu - Lys | -0.806 | NA |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone (Levofloxacin) | 1305 | NA | 435 | Asp - Glu | -3.656 | Germany |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone (Ciprofloxacin) | 1303 | G - A | 435 | Asp - Asn | -4.37 | London in United Kingdom |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone (Levofloxacin) | 1304 | A - T | 435 | Asp - Val | -8.28 | NA |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone | 1305 | NA | 435 | Asp - Glu | -3.656 | Singapore |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone (Levofloxacin / Moxifloxacin) | 1306 | C - A | 436 | Leu - Ile | NA | NA |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone (Ciprofloxacin) | 1330 | G - A | 444 | Gly - Ser | -5.445 | NA |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone (Ciprofloxacin) | 1335 | NA | 445 | Arg - Ser | -5.442 | NA |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone (Levofloxacin) | 1339 | C - T | 447 | Arg - Cys | -6.297 | Germany |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone (Moxifloxacin) | 1360 | C - T | 454 | Pro - Ser | -7.269 | NA |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone (Gemifloxacin / Gatifloxacin / Moxifloxacin) | 1420 | G - A | 474 | Glu - Lys | -2.059 | Canada |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone (Levofloxacin) | 1420 | G - A | 474 | Glu - Lys | -2.059 | Germany |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Quinolone | 1420 | G - A | 474 | Glu - Lys | -2.059 | NA |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone (Gatifloxacin) | 1420 | G - A | 474 | Glu - Lys | -2.059 | United States |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone (Levofloxacin) | 1456 - 1458 | NA | 486 | Gly - Glu | -6.724 | Germany |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone (Levofloxacin) | 1457 | A - G | 486 | Glu - Gly | NA | NA |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone | 1152 | A - G | NA | NA | NA | NA |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone | 1158 | G - A | NA | NA | NA | NA |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone | 1356 | C - T | NA | NA | NA | NA |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone | 1383 | C - T | NA | NA | NA | NA |
| Streptococcus pneumoniae | gyrB | DB40_05905 / DB40_10290 | Fluoroquinolone | 1416 | G - A | NA | NA | NA | NA |
| Streptococcus pneumoniae | rpoB | DB40_06660 | Rifampin | 1444 | TCA - CCA | 482 | Ser - Pro | -2.665 | NA |
| Streptococcus pneumoniae | rpoB | DB40_06660 | Rifampin | 1449 | CAG - CAC | 483 | Gln - His | NA | NA |
| Streptococcus pneumoniae | rpoB | DB40_06660 | Rifampin | 1456 | CAG - AAG | 486 | Gln - Lys | NA | NA |
| Streptococcus pneumoniae | rpoB | DB40_06660 | Rifampin | 1457 | CAG - CTG | 486 | Gln - Leu | NA | NA |
| Streptococcus pneumoniae | rpoB | DB40_06660 | Rifampin | 1465 | GAC - TAC | 489 | Asp - Tyr | NA | NA |
| Streptococcus pneumoniae | rpoB | DB40_06660 | Rifampin | 1466 | GAC - GTC | 489 | Asp - Val | NA | NA |
| Streptococcus pneumoniae | rpoB | DB40_06660 | Rifampin | 1484 | TCT - TTT | 495 | Ser - Phe | NA | NA |
| Streptococcus pneumoniae | rpoB | DB40_06660 | Rifampin | 1495 | CAC - GAC | 499 | His - Asp | NA | NA |
| Streptococcus pneumoniae | rpoB | DB40_06660 | Rifampicin | 1495 | C - A | 499 | His - Asn | NA | NA |
| Streptococcus pneumoniae | rpoB | DB40_06660 | Rifampicin | 1495 | C - T | 499 | His - Tyr | NA | NA |
| Streptococcus pneumoniae | rpoB | DB40_06660 | Rifampin | 1495 | CAC - TAC | 499 | His - Tyr | NA | NA |
| Streptococcus pneumoniae | rpoB | DB40_06660 | Rifampin | 1496 | CAC - CTC | 499 | His - Leu | NA | NA |
| Streptococcus pneumoniae | rpoB | DB40_06660 | Rifampin | 1505 | CGT - CAT | 502 | Arg - His | -4.582 | NA |
| Streptococcus pneumoniae | rpoB | DB40_06660 | Rifampin | 1504 | CGT - TGT | 502 | Arg - Cys | -7.331 | NA |
| Streptococcus pneumoniae | rpoB | DB40_06660 | Rifampin | 1635 | AAC - AAA | 545 | Asn - Lys | NA | NA |
| Streptococcus pneumoniae | rpoB | DB40_06660 | Rifampicin | 1766 | A - T | 589 | Tyr - Phe | NA | NA |
| Streptococcus pneumoniae | rpsL | DB40_07780 | Streptomycin | 301 | AAA - GAA | 101 | Lys - Glu | -3.825 | NA |
| Streptococcus pneumoniae | rpsL | DB40_07780 | Streptomycin | 167 | AAA - ACA | 56 | Lys - Thr | -5.474 | NA |
| Streptococcus pneumoniae | rpsL | DB40_07780 | Streptomycin | 167 | AAA - ATA | 56 | Lys - Ile | -7.326 | NA |
| Streptococcus pneumoniae | rpsL | DB40_07780 | Streptomycin | 167 | AAA - AGA | 56 | Lys - Arg | -2.645 | NA |
| Streptococcus pneumoniae | rpsL | DB40_07780 | Streptomycin | 167 | AAA - ACA | 56 | Lys - Thr | -5.474 | NA |
| Streptococcus pneumoniae | rpsL | DB40_07780 | Streptomycin | 150 | GC - AT | NA | NA | NA | NA |
| Streptococcus pneumoniae | rpsL | DB40_07780 | Streptomycin | 405 | GC - AT | NA | NA | NA | NA |
| Streptococcus pyogenes | rpoB | DP15_1166 | Rifampin | 1565 | C - T | 522 | Ser - Leu | NA | NA |