DRAGdb: Drug Resistance Associated Genes
Number of mutation entries in Streptomyces species is 101
PROVEAN score threshold is -2.5. Variants with score = or < -2.5 are considered deleterious.Variants with score > -2.5 are considered neutral.
| ORGANISM_NAME | GENE_NAME | ENSEMBL_ID | DRUG_NAME | NUCLEOTIDE_POSITION | NUCLEOTIDE_MUTATION | AMINOACID_POSITION | AMINOACID_MUTATION | PROVEAN_SCORE | SAMPLE_LOCATION |
|---|---|---|---|---|---|---|---|---|---|
| Streptomyces albogriseolus | rpoB | NA | Rifampin | 1324 | A - T | 442 | Asn - Tyr | NA | NA |
| Streptomyces albus | rpoB | SLNWT_4565 | Rifampicin | 1325 | C - T | 442 | Ser - Phe | -5.9 | NA |
| Streptomyces albus | rpoB | SLNWT_4565 | Rifampicin | 1325 | C - A | 442 | Ser - Tyr | -5.853 | NA |
| Streptomyces albus | rpsL | NA | Streptomycin | 128 | A - G | 43 | Lys - Arg | NA | NA |
| Streptomyces albus | rpsL | NA | Streptomycin | 263 | A - G | 88 | Lys - Arg | NA | NA |
| Streptomyces antibioticus | gidB / rsmG | ADK77_18535 | Streptomycin | 251 | C - G | 84 | Pro - Arg | -6.779 | NA |
| Streptomyces antibioticus | rpsL | ADK77_42265 | Streptomycin | 262 | A - G | 88 | Lys - Glu | -3.753 | NA |
| Streptomyces antibioticus | rpsL | ADK77_42265 | Streptomycin | 263 | A - G | 88 | Lys - Arg | -2.511 | NA |
| Streptomyces avermitilis | gidB / rsmG | SAVERM_4310 | Streptomycin | 316 | A - G | 106 | Glu - Lys | -3.976 | NA |
| Streptomyces avermitilis | gidB / rsmG | SAVERM_4310 | Streptomycin | 344 | T - G | 115 | Leu - Arg | -5.964 | NA |
| Streptomyces avermitilis | gidB / rsmG | SAVERM_4310 | Streptomycin | 553 | A - T | 185 | Lys - Stop | NA | NA |
| Streptomyces avermitilis | gidB / rsmG | SAVERM_4310 | Streptomycin | 429 | C - CC | NA | NA | NA | NA |
| Streptomyces avermitilis | gidB / rsmG | SAVERM_4310 | Streptomycin | 515 | T - TAGAT | NA | NA | NA | NA |
| Streptomyces avermitilis | rpsL | SAVERM_4917 | Streptomycin | 128 | A - C | 43 | Lys - Thr | -5.498 | NA |
| Streptomyces avermitilis | rpsL | SAVERM_4917 | Streptomycin | 129 | G - C | 43 | Lys - Asn | -4.567 | NA |
| Streptomyces avermitilis | rpsL | SAVERM_4917 | Streptomycin | 129 | G - T | 43 | Lys - Asn | -4.567 | NA |
| Streptomyces avermitilis | rpsL | SAVERM_4917 | Streptomycin | 128 | A - G | 43 | Lys - Arg | -2.657 | NA |
| Streptomyces avermitilis | rpsL | SAVERM_4917 | Streptomycin | 128 | A - T | 43 | Lys - Met | -5.502 | NA |
| Streptomyces avermitilis | rpsL | SAVERM_4917 | Streptomycin | 262 | A - G | 88 | Lys - Glu | -3.753 | NA |
| Streptomyces avermitilis | rpsL | SAVERM_4917 | Streptomycin | 263 | A - G | 88 | Lys - Arg | -2.511 | NA |
| Streptomyces avermitilis | rpsL | SAVERM_4917 | Streptomycin | 263 | A - T | 88 | Lys - Met | -5.637 | NA |
| Streptomyces coelicolor | gidB / rsmG | CAB42703 | Streptomycin | 21 | C - CC | 10 | Val - Cys | -1.046 | NA |
| Streptomyces coelicolor | gidB / rsmG | CAB42703 | Streptomycin | 427 | G - A | 143 | Ala - Thr | -4 | NA |
| Streptomyces coelicolor | gidB / rsmG | CAB42703 | Streptomycin | 46 - 48 | NA | 16 | Asp - Stop | NA | NA |
| Streptomyces coelicolor | gidB / rsmG | CAB42703 | Streptomycin | 488 | A - Deletion | 163 | Glu - Gly | -3.426 | NA |
| Streptomyces coelicolor | gidB / rsmG | CAB42703 | Streptomycin | 484 | G - GG | 163 | Glu - Gly | -3.426 | NA |
| Streptomyces coelicolor | gidB / rsmG | CAB42703 | Streptomycin | 503 | A - G | 168 | Gln - Arg | NA | NA |
| Streptomyces coelicolor | gidB / rsmG | CAB42703 | Streptomycin | 526 - 528 | NA | 176 | Leu - Stop | NA | NA |
| Streptomyces coelicolor | gidB / rsmG | CAB42703 | Streptomycin | 568 | C - T | 190 | Gln - Stop | NA | NA |
| Streptomyces coelicolor | gidB / rsmG | CAB42703 | Streptomycin | 627 | A - TA | 210 | Val - Ser | -3.213 | NA |
| Streptomyces coelicolor | gidB / rsmG | CAB42703 | Streptomycin | 21 | C - Deletion | 37 | Val - Stop | NA | NA |
| Streptomyces coelicolor | gidB / rsmG | CAB42703 | Streptomycin | 160 | C - A | 54 | His - Asn | -6.958 | NA |
| Streptomyces coelicolor | gidB / rsmG | CAB42703 | Streptomycin | 160 | C - T | 54 | His - Tyr | -5.964 | NA |
| Streptomyces coelicolor | gidB / rsmG | CAB42703 | Streptomycin | 21 | C - CC | NA | NA | NA | NA |
| Streptomyces coelicolor | rpsL | CAB81850 | Streptomycin | 257 | G - C | 86 | Arg - Pro | -6.815 | NA |
| Streptomyces coelicolor | rpsL | CAB81850 | Streptomycin | 262 | A - G | 88 | Lys - Glu | -3.753 | NA |
| Streptomyces coelicolor | rpsL | CAB81850 | Paromomycin | 274 - 276 | NA | 92 | Gly - Insertion | NA | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 995 | T - C | 332 | Leu - Arg | NA | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1011 | C - A | 337 | Asp - Glu | NA | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1010 | A - G | 337 | Asp - Gly | NA | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1028 | C - T | 343 | Ser - Leu | NA | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1040 | A - G | 347 | His - Arg | NA | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1039 | C - T | 347 | His - Tyr | NA | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1041 | C - A | 347 | His - Gln | NA | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1049 | G - A | 350 | Arg - His | NA | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1049 | G - T | 350 | Arg - Phe | NA | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1048 | C - T | 350 | Arg - Cys | NA | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1154 | C - T | 385 | Pro - Leu | NA | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1179 | C - G | 393 | Ile - Met | NA | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1265 | T - C | 422 | Leu - Pro | -6.996 | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1268 | C - A | 423 | Ser -Tyr | -5.999 | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1271 | A - T | 424 | Gln - Leu | -6.999 | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1278 | G - A | 426 | Met - Ile | -3.983 | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1280 | A - G | 427 | Asp - Gly | -6.981 | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1280 | A - T | 427 | Asp - Val | -8.984 | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1297 | T - C | 433 | Ser - Pro | -2.758 | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1310 | A - G | 437 | His - Arg | -7.487 | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1311 | C - A | 437 | His - Gln | -7.487 | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1318 | C - G | 440 | Arg - Gly | -6.999 | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1318 | C - T | 440 | Arg - Cys | -7.999 | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1319 | G - A | 440 | Arg - His | -4.999 | NA |
| Streptomyces coelicolor A3(2) | rpoB | CAB77428 | Rifampin | 1319 | G - T | 440 | Arg - Leu | -6.999 | NA |
| Streptomyces coelicolor A3(2) | rpsL | CAB81850 | Streptomycin | 129 | NA | 43 | Lys - Asn | -4.567 | NA |
| Streptomyces coelicolor A3(2) | rpsL | CAB81850 | Streptomycin | 128 | A - C | 43 | Lys - Thr | -5.498 | NA |
| Streptomyces coelicolor A3(2) | rpsL | CAB81850 | Streptomycin | 128 | A - G | 43 | Lys - Arg | -2.657 | NA |
| Streptomyces coelicolor A3(2) | rpsL | CAB81850 | Streptomycin | 262 | A - G | 88 | Lys - Glu | -3.753 | NA |
| Streptomyces coelicolor A3(2) | rpsL | CAB81850 | Streptomycin | 263 | A - G | 88 | Lys - Arg | -2.511 | NA |
| Streptomyces coelicolor A3(2) | rpsL | CAB81850 | Streptomycin / Paromomycin | 272 | C - T | 91 | Pro - Ser | -7.811 | NA |
| Streptomyces erythraea | gidB / rsmG | NA | Streptomycin | 56 | A - T | 19 | Glu - Val | NA | NA |
| Streptomyces erythraea | gidB / rsmG | NA | Streptomycin | 8 | G - A | 3 | Gly - Asp | NA | NA |
| Streptomyces erythraea | gidB / rsmG | NA | Streptomycin | 200 | T - C | 67 | Ala - Val | NA | NA |
| Streptomyces erythraea | gidB / rsmG | NA | Streptomycin | 38 - 48 | T to C - Deletion | NA | NA | NA | NA |
| Streptomyces globisporus | rpsL | WQO_21330 | Streptomycin | 128 | A - G | 43 | Lys - Arg | -2.657 | NA |
| Streptomyces incarnatus | rpoB | ABB07_15720 | Rifampicin | 1340 | A - G | 447 | Asp - Gly | NA | NA |
| Streptomyces lividans | gidB / rsmG | SLI_4142 | Streptomycin | 21 | C - CC | 10 | Val - Cys | -1.295 | NA |
| Streptomyces lividans | gidB / rsmG | SLI_4142 | Streptomycin | 377 | C - Deletion | 127 | Glu - Lys | NA | NA |
| Streptomyces lividans | gidB / rsmG | SLI_4142 | Streptomycin | 368 | G - Deletion | 134 | Gly - Ala | NA | NA |
| Streptomyces lividans | gidB / rsmG | SLI_4142 | Streptomycin | 415 - 417 | NA | 139 | Val - Stop | NA | NA |
| Streptomyces lividans | gidB / rsmG | SLI_4142 | Streptomycin | 434 - 439 | Deletion | 145 - 147 | Ala Pro Leu Val - Deletion | NA | NA |
| Streptomyces lividans | gidB / rsmG | SLI_4142 | Streptomycin | 440 | T - C | 147 | Leu - Pro | NA | NA |
| Streptomyces lividans | gidB / rsmG | SLI_4142 | Streptomycin | 46 - 48 | NA | 16 | Asp - Stop | NA | NA |
| Streptomyces lividans | gidB / rsmG | SLI_4142 | Streptomycin | 616 | A - AA | 206 | Thr - Asn | NA | NA |
| Streptomyces lividans | gidB / rsmG | SLI_4142 | Streptomycin | 127 | G - T | 43 | Gly - Cys | NA | NA |
| Streptomyces lividans | gidB / rsmG | SLI_4142 | Streptomycin | 218 | A - G | 73 | Asp - Gly | NA | NA |
| Streptomyces lividans | rpoB | SLI_4926 | Rifampicin | 1280 | A - C | 427 | Asp - Ala | -7.984 | NA |
| Streptomyces lividans | rpoB | SLI_4926 | Rifampicin | 1279 | G - A | 427 | Asp - Asn | -4.989 | NA |
| Streptomyces lividans | rpoB | SLI_4926 | Rifampicin | 1309 | C - T | 437 | His - Tyr | -5.78 | NA |
| Streptomyces lividans | rpoB | SLI_4926 | Rifampicin | 1310 | A - G | 437 | His - Arg | -7.487 | NA |
| Streptomyces lividans | rpoB | SLI_4926 | Rifampicin | 1318 | C - T | 440 | Arg - Cys | -7.999 | NA |
| Streptomyces lividans | rpoB | SLI_4926 | Rifampicin | 1318 | C - T | 440 | Arg - Cys | -7.999 | NA |
| Streptomyces lividans | rpsL | NA | Streptomycin | 128 | A - G | 43 | Lys - Arg | NA | NA |
| Streptomyces lividans 66 | rpsL | NA | Streptomycin | 262 | A - G | 88 | Lys - Glu | NA | NA |
| Streptomyces parvulus | gidB / rsmG | Spa2297_16550 | Streptomycin | 233 | C - T | 78 | Ala - Val | -3.976 | NA |
| Streptomyces parvulus | gidB / rsmG | Spa2297_16550 | Streptomycin | 239 | T - C | 80 | Leu - Pro | -6.858 | NA |
| Streptomyces parvulus | rpsL | Spa2297_19665 | Streptomycin | 128 | A - G | 43 | Lys - Arg | -2.657 | NA |
| Streptomyces parvulus | rpsL | Spa2297_19665 | Streptomycin | 263 | A - G | 88 | Lys - Arg | -2.511 | NA |
| Streptomyces spectabilis | rpoB | NA | Rifampin | 1327 | G - T | 443 | Ala - Ser | NA | NA |
| Streptomyces vinaceus | rpoB | NA | Rifampin | 1309 | C - T | 437 | His - Tyr | NA | NA |
| Streptomyces viridochromogenes | rpsL | ACM01_34225 | Streptomycin | 263 | NA | 88 | Lys - Arg | -2.511 | NA |
| Streptomyces xiamenensis | rpsL | SXIM_21040 | Streptomycin | 262 | A - G | 88 | Lys - Glu | NA | NA |
| Streptomyces xiamenensis | rpsL | SXIM_21040 | Streptomycin | 268 | CT - AA | 90 | Leu - Lys | NA | NA |