DRAGdb: Drug Resistance Associated Genes
Number of mutation entries of rpsL in Other bacteria is 129
PROVEAN score threshold is -2.5. Variants with score = or < -2.5 are considered deleterious.Variants with score > -2.5 are considered neutral.
| ORGANISM_NAME | GENE_NAME | ENSEMBL_ID | DRUG_NAME | NUCLEOTIDE_POSITION | NUCLEOTIDE_MUTATION | AMINOACID_POSITION | AMINOACID_MUTATION | PROVEAN_SCORE | SAMPLE_LOCATION |
|---|---|---|---|---|---|---|---|---|---|
| Streptomyces viridochromogenes | rpsL | ACM01_34225 | Streptomycin | 263 | NA | 88 | Lys - Arg | -2.511 | NA |
| Streptomyces antibioticus | rpsL | ADK77_42265 | Streptomycin | 262 | A - G | 88 | Lys - Glu | -3.753 | NA |
| Streptomyces antibioticus | rpsL | ADK77_42265 | Streptomycin | 263 | A - G | 88 | Lys - Arg | -2.511 | NA |
| Xanthomonas oryzae | rpsL | ADT27_05630 | Streptomycin | 263 | AAG - AGG | 88 | Lys - Arg | -2.703 | NA |
| Xanthomonas oryzae | rpsL | ADT27_05630 | Streptomycin | 128 | AAG - AGG | 43 | Lys - Arg | -2.643 | NA |
| Veillonella parvula | rpsL | AT982_00625 | Streptomycin | 129 | NA | 43 | Lys - Asn | -4.503 | NA |
| Borrelia burgdorferi | rpsL | BB_0387 | Streptomycin | 262 | A - G | 88 | Lys - Glu | -3.818 | NA |
| Bifidobacterium bifidum | rpsL | BIFI_1788 | Streptomycin | 128 | A - G | 43 | Lys - Arg | -2.681 | NA |
| Streptomyces coelicolor A3(2) | rpsL | CAB81850 | Streptomycin / Paromomycin | 272 | C - T | 91 | Pro - Ser | -7.811 | NA |
| Streptomyces coelicolor | rpsL | CAB81850 | Streptomycin | 257 | G - C | 86 | Arg - Pro | -6.815 | NA |
| Streptomyces coelicolor A3(2) | rpsL | CAB81850 | Streptomycin | 128 | A - C | 43 | Lys - Thr | -5.498 | NA |
| Streptomyces coelicolor A3(2) | rpsL | CAB81850 | Streptomycin | 129 | NA | 43 | Lys - Asn | -4.567 | NA |
| Streptomyces coelicolor | rpsL | CAB81850 | Streptomycin | 262 | A - G | 88 | Lys - Glu | -3.753 | NA |
| Streptomyces coelicolor A3(2) | rpsL | CAB81850 | Streptomycin | 262 | A - G | 88 | Lys - Glu | -3.753 | NA |
| Streptomyces coelicolor A3(2) | rpsL | CAB81850 | Streptomycin | 128 | A - G | 43 | Lys - Arg | -2.657 | NA |
| Streptomyces coelicolor A3(2) | rpsL | CAB81850 | Streptomycin | 263 | A - G | 88 | Lys - Arg | -2.511 | NA |
| Streptomyces coelicolor | rpsL | CAB81850 | Paromomycin | 274 - 276 | NA | 92 | Gly - Insertion | NA | NA |
| Corynebacterium glutamicum | rpsL | CGLAR1_02900 | Streptomycin | 128 | A - G | 43 | Lys - Arg | -2.65 | NA |
| Clostridium saccharoperbutylacetonicum | rpsL | Cspa_c01830 | Streptomycin | 129 | G - A | 43 | Lys - Asn | -4.489 | NA |
| Campylobacter upsaliensis | rpsL | CUP1684 | Streptomycin | 263 | AAA - AGA | 88 | Lys - Arg | NA | NA |
| Salmonella enterica Serovar Typhimurium | rpsL | CY43_17935 | Streptomycin | 125 | A - G | 42 | Lys - Arg | NA | NA |
| Salmonella enterica Serovar Typhimurium | rpsL | CY43_17935 | Streptomycin | 126 | AAA - AAC | 42 | Lys - Asn | NA | NA |
| Salmonella enterica Serovar Typhimurium | rpsL | CY43_17935 | Streptomycin | 126 | NA | 42 | Lys - Asn | NA | NA |
| Salmonella enterica Serovar Typhimurium | rpsL | CY43_17935 | Streptomycin | 125 | AAA - AGA | 42 | Lys - Arg | NA | NA |
| Salmonella enterica Serovar Typhimurium | rpsL | CY43_17935 | Streptomycin | 269 | C - T | 90 | Pro - Ser | NA | NA |
| Salmonella enterica Serovar Typhimurium | rpsL | CY43_17935 | Streptomycin | NA | AAA - AGA | NA | Lys - Arg | NA | NA |
| Salmonella enterica Serovar Typhimurium | rpsL | CY43_17935 | Streptomycin | NA | AAA - AAC | NA | Lys - Asn | NA | NA |
| Salmonella enterica Serovar Typhimurium | rpsL | CY43_17935 | Streptomycin | NA | AAA - ACA | NA | Lys - Thr | NA | NA |
| Streptococcus pneumoniae | rpsL | DB40_07780 | Streptomycin | 167 | AAA - ATA | 56 | Lys - Ile | -7.326 | NA |
| Streptococcus pneumoniae | rpsL | DB40_07780 | Streptomycin | 167 | AAA - ACA | 56 | Lys - Thr | -5.474 | NA |
| Streptococcus pneumoniae | rpsL | DB40_07780 | Streptomycin | 167 | AAA - ACA | 56 | Lys - Thr | -5.474 | NA |
| Streptococcus pneumoniae | rpsL | DB40_07780 | Streptomycin | 301 | AAA - GAA | 101 | Lys - Glu | -3.825 | NA |
| Streptococcus pneumoniae | rpsL | DB40_07780 | Streptomycin | 167 | AAA - AGA | 56 | Lys - Arg | -2.645 | NA |
| Streptococcus pneumoniae | rpsL | DB40_07780 | Streptomycin | 150 | GC - AT | NA | NA | NA | NA |
| Streptococcus pneumoniae | rpsL | DB40_07780 | Streptomycin | 405 | GC - AT | NA | NA | NA | NA |
| Pseudomonas putida | rpsL | DW66_0458 | Streptomycin | 263 | A - G | 88 | Lys - Arg | -2.603 | NA |
| Pseudomonas putida | rpsL | DW66_0458 | Streptomycin | 128 | A - G | 43 | Lys - Arg | -2.479 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 167 | AAA - ATA | 56 | Lys - Ile | -7.203 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 167 | AAA - ATA | 56 | Lys - Ile | -7.203 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 64 | C - T | 22 | Pro - Ser | -6.095 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 167 | AAA - ACA | 56 | Lys - Thr | -5.39 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 167 | AAA - ACA | 56 | Lys - Thr | -5.39 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 168 | AAA - AAT | 56 | Lys - Asn | -4.484 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 168 | AAA - AAT | 56 | Lys - Asn | -4.484 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 166 | AAA - CAA | 56 | Lys - Gln | -3.585 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 166 | AAA - CAA | 56 | Lys - Gln | -3.585 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 167 | AAA - AGA | 56 | Lys - Arg | -2.647 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 167 | AAA - AGA | 56 | Lys - Arg | -2.647 | NA |
| Bacillus subtilis | rpsL | EF83_17525 | Streptomycin | 167 | AAA - AGA | 56 | Lys - Arg | -2.647 | NA |
| Lysinibacillus sphaericus | rpsL | EP18_11520 | Streptomycin | 167 | A - G | 56 | Lys - Arg | NA | NA |
| Helicobacter pylori | rpsL | HP2RS_03782 | Streptomycin | 263 | AAG - AGG | 88 | Lys - Arg | -2.609 | NA |
| Helicobacter pylori | rpsL | HP2RS_03782 | Streptomycin | 128 | AAA - AGA | 43 | Lys - Arg | -2.525 | NA |
| Helicobacter pylori | rpsL | HP2RS_03782 | Streptomycin | 128 | AAA - AGA | 43 | Lys - Arg | -2.525 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 269 | CCG - CTG | 91 | Pro - Leu | -9.6 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 269 | CCG - CAG | 91 | Pro - Gln | -7.681 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 126 | NA | 42 | Lys - Ile | -7.465 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 272 | GGT - GAT | 92 | Gly - Asp | -6.71 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 125 | A - C | 42 | Lys - Thr | -5.562 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 125 | AAA - ACA | 42 | Lys - Thr | -5.562 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 125 | AAA - ACA | 42 | Lys - Thr | -5.562 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 125 | AAA - ACA | 42 | Lys - Thr | -5.562 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 126 | NA | 42 | Lys - Asn | -4.612 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 126 | AAA - AAC | 42 | Lys - Asn | -4.612 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 126 | A - C | 42 | Lys - Asn | -4.612 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 264 | A - C | 87 | Lys - Asn | -4.58 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 259 | A - G | 87 | Lys - Glu | -3.688 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 259 | AAA - GAA | 87 | Lys - Glu | -3.688 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 125 | A - G | 42 | Lys - Arg | -2.591 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 125 | AAA - AGA | 42 | Lys - Arg | -2.591 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 260 | AAA - AGA | 87 | Lys - Arg | -2.453 | NA |
| Escherichia coli | rpsL | HUS2011_3971 | Streptomycin | 263 | AAA - AGA | 87 | Lys - Arg | -2.453 | NA |
| Erwinia amylovora | rpsL | LA635_3088 | Streptomycin | 128 | A - G | 43 | Lys - Arg | NA | NA |
| Erwinia amylovora | rpsL | LA635_3088 | Streptomycin | 128 | A - G | 43 | Lys - Arg | NA | NA |
| Legionella pneumophila | rpsL | lpbnt_00433 | Streptomycin | 129 | NA | 43 | Lys - Asn | -4.565 | NA |
| Legionella pneumophila | rpsL | lpbnt_00433 | Streptomycin | 263 | AAA - AGA | 88 | Lys - Arg | -2.703 | NA |
| Mycobacterium abscessus | rpsL | MAB_3851c | Streptomycin | 129 | NA | 43 | Lys - Asn | -4.577 | NA |
| Mycobacterium abscessus | rpsL | MAB_3851c | Streptomycin | 128 | A - G | 43 | Lys - Arg | -2.653 | NA |
| Mycobacterium abscessus | rpsL | MAB_3851c | Streptomycin | 263 | A - G | 88 | Lys - Arg | -2.503 | NA |
| Mycobacterium bovis | rpsL | Mb0701 | Streptomycin | NA | GCT - GCG | NA | Ala - Ala | NA | NA |
| Mycobacterium caprae | rpsL | MBO_200929 | Streptomycin | NA | GCT - GCG | NA | Ala - Ala | NA | NA |
| Mycobacterium smegmatis | rpsL | MSMEG_1398 | Streptomycin | 272 | C - A | 91 | Pro - His | -8.812 | NA |
| Mycobacterium smegmatis | rpsL | MSMEG_1398 | Streptomycin | 262 | A - G | 88 | Lys - Glu | -3.761 | NA |
| Mycobacterium smegmatis | rpsL | MSMEG_1398 | Streptomycin | 128 | A - G | 43 | Lys - Arg | -2.65 | NA |
| Mycobacterium smegmatis | rpsL | MSMEG_1398 | Streptomycin | NA | AAG - AGG | NA | Lys - Arg | NA | NA |
| Mycobacterium smegmatis | rpsL | MSMEG_1398 | Streptomycin | NA | AAG - AAC | NA | Lys - Asn | NA | NA |
| Mycobacterium smegmatis | rpsL | MSMEG_1398 | Streptomycin | NA | AAG - AAT | NA | Lys - Asn | NA | NA |
| Mycobacterium smegmatis | rpsL | MSMEG_1398 | Streptomycin | NA | AAG - ACG | NA | Lys - Thr | NA | NA |
| Saccharopolyspora erythraea | rpsL | SACE_6841 | Streptomycin | 272 | C - A | 91 | Pro - His | -8.812 | NA |
| Saccharopolyspora erythraea | rpsL | SACE_6841 | Streptomycin | 274 | G - C | 92 | Gly - Arg | -7.821 | NA |
| Saccharopolyspora erythraea | rpsL | SACE_6841 | Streptomycin | 256 | C - T | 86 | Arg - Cys | -7.82 | NA |
| Saccharopolyspora erythraea | rpsL | SACE_6841 | Streptomycin | 124 | C - G | 42 | Pro - Ala | -7.481 | NA |
| Saccharopolyspora erythraea | rpsL | SACE_6841 | Streptomycin | 128 | A - T | 43 | Lys - Met | -5.516 | NA |
| Saccharopolyspora erythraea | rpsL | SACE_6841 | Streptomycin | 122 | C - T | 41 | Thr - Ile | -5.476 | NA |
| Saccharopolyspora erythraea | rpsL | SACE_6841 | Streptomycin | 132 | G - C | 44 | Lys - Asn | -4.657 | NA |
| Saccharopolyspora erythraea | rpsL | SACE_6841 | Streptomycin | 129 | G - T | 43 | Lys - Asn | -4.582 | NA |
| Saccharopolyspora erythraea | rpsL | SACE_6841 | Streptomycin | 128 | A - G | 43 | Lys - Arg | -2.663 | NA |
| Saccharopolyspora erythraea | rpsL | SACE_6841 | Streptomycin | 263 | A - G | 88 | Lys - Arg | -2.508 | NA |
| Streptomyces avermitilis | rpsL | SAVERM_4917 | Streptomycin | 263 | A - T | 88 | Lys - Met | -5.637 | NA |
| Streptomyces avermitilis | rpsL | SAVERM_4917 | Streptomycin | 128 | A - T | 43 | Lys - Met | -5.502 | NA |
| Streptomyces avermitilis | rpsL | SAVERM_4917 | Streptomycin | 128 | A - C | 43 | Lys - Thr | -5.498 | NA |
| Streptomyces avermitilis | rpsL | SAVERM_4917 | Streptomycin | 129 | G - C | 43 | Lys - Asn | -4.567 | NA |
| Streptomyces avermitilis | rpsL | SAVERM_4917 | Streptomycin | 129 | G - T | 43 | Lys - Asn | -4.567 | NA |
| Streptomyces avermitilis | rpsL | SAVERM_4917 | Streptomycin | 262 | A - G | 88 | Lys - Glu | -3.753 | NA |
| Streptomyces avermitilis | rpsL | SAVERM_4917 | Streptomycin | 128 | A - G | 43 | Lys - Arg | -2.657 | NA |
| Streptomyces avermitilis | rpsL | SAVERM_4917 | Streptomycin | 263 | A - G | 88 | Lys - Arg | -2.511 | NA |
| Streptomyces parvulus | rpsL | Spa2297_19665 | Streptomycin | 128 | A - G | 43 | Lys - Arg | -2.657 | NA |
| Streptomyces parvulus | rpsL | Spa2297_19665 | Streptomycin | 263 | A - G | 88 | Lys - Arg | -2.511 | NA |
| Streptomyces xiamenensis | rpsL | SXIM_21040 | Streptomycin | 262 | A - G | 88 | Lys - Glu | NA | NA |
| Streptomyces xiamenensis | rpsL | SXIM_21040 | Streptomycin | 268 | CT - AA | 90 | Leu - Lys | NA | NA |
| Campylobacter coli | rpsL | VC76_02580 | Streptomycin | 263 | AAG - AGG | 88 | Lys - Arg | -2.703 | NA |
| Campylobacter coli | rpsL | VC76_02580 | Streptomycin | 128 | AAG - AGG | 43 | Lys - Arg | -2.628 | NA |
| Streptomyces globisporus | rpsL | WQO_21330 | Streptomycin | 128 | A - G | 43 | Lys - Arg | -2.657 | NA |
| Thermus thermophilus | rpsL | NA | Streptomycin | 122 | CCC - CTC | 41 | Pro - Ser | NA | NA |
| Thermus thermophilus | rpsL | NA | Streptomycin | 125 | AAG - AGG | 42 | Lys - Arg | NA | NA |
| Salmonella sps. | rpsL | NA | Streptomycin | 126 | NA | 42 | Lys - Asn | NA | Moscow in Russia |
| Streptomyces albus | rpsL | NA | Streptomycin | 128 | A - G | 43 | Lys - Arg | NA | NA |
| Leptospira sps. | rpsL | NA | Streptomycin | 128 | AAA - AGA | 43 | Lys - Arg | NA | NA |
| Streptomyces lividans | rpsL | NA | Streptomycin | 128 | A - G | 43 | Lys - Arg | NA | NA |
| Erwinia carotovora | rpsL | NA | Streptomycin | 128 | A - G | 43 | Lys - Arg | NA | NA |
| Erwinia carotovora | rpsL | NA | Streptomycin | 129 | NA | 43 | Lys - Asn | NA | NA |
| Erwinia carotovora | rpsL | NA | Streptomycin | 128 | A - C | 43 | Lys - Thr | NA | NA |
| Bifidobacterium breve | rpsL | NA | Streptomycin | 128 | A - G | 43 | Lys - Arg | NA | NA |
| Thermus thermophilus | rpsL | NA | Streptomycin | 260 | AAG - AGG | 87 | Lys - Arg | NA | NA |
| Thermus thermophilus | rpsL | NA | Streptomycin | 259 | AAG - GAG | 87 | Lys - Glu | NA | NA |
| Streptomyces albus | rpsL | NA | Streptomycin | 263 | A - G | 88 | Lys - Arg | NA | NA |
| Leptospira sps. | rpsL | NA | Streptomycin | 263 | AAA - AGA | 88 | Lys - Arg | NA | NA |
| Leptospira biflexa | rpsL | NA | Streptomycin | 263 | AAA - AGA | 88 | Lys - Arg | NA | NA |
| Streptomyces lividans 66 | rpsL | NA | Streptomycin | 262 | A - G | 88 | Lys - Glu | NA | NA |
| Salmonella sps. | rpsL | NA | Streptomycin | 272 | G - A | 91 | Gly - Asp | NA | Moscow in Russia |