Record No:1
| ACCESS NO | D100176 |
| GENE_NAME | IL1A |
| DESCRIPTION | Interleukin - 1alpha |
| ALIASES | IL-1A, IL1, IL1-ALPHA, IL1F1. |
| NCBI_ENTREZ_NO | 3552 |
| UNIPROT_ACCESS_NO | P01583 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma and effect of house dust mite allergens on human airway epithelial cell. |
| SAMPLE | Airway Epithelial Cells |
| TECHNIQUES | Microarray and qPCR |
| OMICS | Genomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | This is a cell communication protein significantly upregulated in asthma. |
| REFERENCE | 17919147 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Cytokine activity, interleukin-1 receptor binding, copper ion binding, protein binding. |
| GO_BIOLOGICAL_PROCESS | Fever generation, connective tissue replacement involved in inflammatory response wound healing, apoptotic process, inflammatory response, immune response, cell proliferation, negative regulation of cell proliferation, regulation of signaling receptor activity, positive regulation of vascular endothelial growth factor production, positive regulation of gene expression, cytokine-mediated signaling pathway, positive regulation of interleukin-6 production, cellular response to heat, ectopic germ cell programmed cell death, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of interleukin-2 biosynthetic process, positive regulation of angiogenesis, positive regulation of mitotic nuclear division, positive regulation of transcription by RNA polymerase II, positive regulation of JNK cascade, response to copper ion, positive regulation of protein secretion, positive regulation of cytokine secretion, positive regulation of cell division, positive regulation of ERK1 and ERK2 cascade, interleukin-1-mediated signaling pathway, positive regulation of monocyte chemotactic protein-1 production, extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of neutrophil extravasation, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. |
| BIOGRID_INTERACTION_ID | 109768 |
| SNP_ID | 300257 301183 300972 |
| DRUG_ID | 4159 |
| STRUCTURE_ID | 200304 200305 |
| MONOCLONAL_ANTIBODY | Anti-IL-1 alpha antibody for Human, Rat, Goat, Mouse. |