Record No:1
| ACCESS NO | D100183 |
| GENE_NAME | EREG |
| DESCRIPTION | Epiregulin |
| ALIASES | EPR, ER, Ep. |
| NCBI_ENTREZ_NO | 2069 |
| UNIPROT_ACCESS_NO | O14944 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma and effect of house dust mite allergens on human airway epithelial cell. |
| SAMPLE | Airway Epithelial Cells |
| TECHNIQUES | Microarray |
| OMICS | Genomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | This is a cell communication protein significantly upregulated in asthma. |
| REFERENCE | 17919147 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Protein tyrosine kinase activity, Ras guanyl-nucleotide exchange factor activity, epidermal growth factor receptor binding, protein binding, growth factor activity. |
| GO_BIOLOGICAL_PROCESS | MAPK cascade, angiogenesis, ovarian cumulus expansion, oocyte maturation, positive regulation of cytokine production, female meiotic nuclear division, epidermal growth factor receptor signaling pathway, cell-cell signaling, multicellular organism development, positive regulation of cell proliferation, negative regulation of cell proliferation, mRNA transcription, anatomical structure morphogenesis, animal organ morphogenesis, peptidyl-tyrosine phosphorylation, cytokine-mediated signaling pathway, cell differentiation, keratinocyte differentiation, ovulation, ERBB2 signaling pathway, wound healing, positive regulation of cytokine biosynthetic process, positive regulation of phosphorylation, luteinizing hormone signaling pathway, response to peptide hormone, keratinocyte proliferation, positive regulation of innate immune response, positive regulation of interleukin-6 biosynthetic process, positive regulation of DNA replication, positive regulation of epidermal growth factor-activated receptor activity, positive regulation of mitotic nuclear division, positive regulation of protein kinase activity, negative regulation of DNA-templated transcription, phosphatidylinositol phosphorylation, positive regulation of fibroblast proliferation, primary follicle stage, positive regulation of smooth muscle cell proliferation, negative regulation of epithelial cell proliferation, negative regulation of smooth muscle cell differentiation, positive regulation of cell division, positive regulation of protein kinase B signaling, negative regulation of ERBB signaling pathway, regulation of cell motility. |
| BIOGRID_INTERACTION_ID | 108381 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 200323 200324 |
| MONOCLONAL_ANTIBODY | Anti-EREG antibody for Human, Mouse. |