Record No:1
| ACCESS NO | D100207 |
| GENE_NAME | EPHA4 |
| DESCRIPTION | Ephrin receptor A4 |
| ALIASES | EK8, HEK8, SEK, TYRO1. |
| NCBI_ENTREZ_NO | 2043 |
| UNIPROT_ACCESS_NO | P54764 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma and effect of house dust mite allergens on human airway epithelial cell. |
| SAMPLE | Airway Epithelial Cells |
| TECHNIQUES | Microarray |
| OMICS | Genomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | This is a cell communication protein significantly down regulated in asthma. |
| REFERENCE | 17919147 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Protein kinase activity, MAP kinase kinase kinase activity, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity, transmembrane signaling receptor activity, ephrin receptor activity, GPI-linked ephrin receptor activity, transmembrane-ephrin receptor activity, protein binding, ATP binding, kinase activity, transferase activity, mitogen-activated protein kinase kinase binding, PH domain binding, identical protein binding, ephrin receptor binding, DH domain binding, protein tyrosine kinase binding. |
| GO_BIOLOGICAL_PROCESS | Protein phosphorylation, cell adhesion, transmembrane receptor protein tyrosine kinase signaling pathway, multicellular organism development, nervous system development, axon guidance, adult walking behavior, motor neuron axon guidance, glial cell migration, negative regulation of signal transduction, negative regulation of neuron projection development, phosphorylation, peptidyl-tyrosine phosphorylation, corticospinal tract morphogenesis, cell differentiation, negative regulation of axon extension, positive regulation of kinase activity, negative regulation of apoptotic process, regulation of GTPase activity, positive regulation of MAPK cascade, positive regulation of JUN kinase activity, protein autophosphorylation, ephrin receptor signaling pathway, negative regulation of axon regeneration, regulation of astrocyte differentiation, regulation of axonogenesis, positive regulation of dendrite morphogenesis, protein stabilization, regulation of dendritic spine morphogenesis, positive regulation of protein tyrosine kinase activity, positive regulation of ERK1 and ERK2 cascade, nephric duct morphogenesis, fasciculation of sensory neuron axon, fasciculation of motor neuron axon, neuron projection guidance, neuron projection fasciculation, negative regulation of long-term synaptic potentiation, positive regulation of amyloid-beta formation, positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process, negative regulation of proteolysis involved in cellular protein catabolic process, cellular response to amyloid-beta, regulation of modification of synaptic structure, positive regulation of Rho guanyl-nucleotide exchange factor activity. |
| BIOGRID_INTERACTION_ID | 108357 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 200377 200378 200379 200380 200381 200382 200383 200384 20385 200386 200387 |
| MONOCLONAL_ANTIBODY | Anti-EPH A3+A4+A5 (phospho Y779 + Y779 + Y833) antibody for Mouse, Rat, Human; Anti-Eph receptor A4/SEK antibody for Mouse, Human. |